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Home Aminos 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione

2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione

CAS No.:
1218942-37-0
Catalog Number:
AG0016BZ
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.8542
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$96
- +
5mg
99%
1 week
United States
$207
- +
10mg
99%
1 week
United States
$290
- +
100mg
97+%
1 week
United States
$391
- +
250mg
97+%
1 week
United States
$703
- +
1g
97+%
1 week
United States
$1992
- +
Product Description
Catalog Number:
AG0016BZ
Chemical Name:
2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione
CAS Number:
1218942-37-0
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.8542
MDL Number:
MFCD27923122
IUPAC Name:
2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
InChI:
InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3
InChI Key:
RGYQPQARIQKJKH-UHFFFAOYSA-N
SMILES:
Clc1ccccc1n1[nH]c2c(c1=O)c(c1cccc(c1)N(C)C)n(c(=O)c2)C
UNII:
45II35329V
Properties
Complexity:
732  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
394.12g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
394.859g/mol
Monoisotopic Mass:
394.12g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
55.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
Dual oxidase: a novel therapeutic target in allergic disease. British journal of pharmacology 20180501
Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. The Journal of pharmacology and experimental therapeutics 20150401
Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina. Journal of neuroinflammation 20150101
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (Baltimore, Md.) 20121201
The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. American journal of respiratory cell and molecular biology 20121101
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free radical biology & medicine 20120715
Properties