[Management of osteoarthritis: oral therapies].

La Revue du praticien 20120501

Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.

Diabetes care 20120201

Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.

International journal of rheumatic diseases 20120201

[Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.

Current medical research and opinion 20120101

Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.

Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101

Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

International journal of molecular sciences 20120101

Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein.

PDA journal of pharmaceutical science and technology 20120101

Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.

TheScientificWorldJournal 20120101

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.

Medical hypotheses 20111201

Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.

Endocrinology 20111101

Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000.

Drug development and industrial pharmacy 20111001

Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.

Diabetes care 20110701

Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.

Annals of the rheumatic diseases 20110601

Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.

Drug testing and analysis 20110401

Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.

Naunyn-Schmiedeberg's archives of pharmacology 20110301

Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.

Yonsei medical journal 20110301

Lyprinol-is it a useful anti-inflammatory agent?

Evidence-based complementary and alternative medicine : eCAM 20110101

Comparison of general practitioners and rheumatologists' prescription patterns for patients with knee osteoarthritis.

BMC musculoskeletal disorders 20110101

Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis.

BMC medicine 20110101

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis.

Arthritis research & therapy 20110101

T'ai chi for the treatment of osteoarthritis: a systematic review and meta-analysis.

BMJ open 20110101

[Pharmacological therapies for osteoarthritis].

Therapie 20110101

Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.

Indian journal of pharmaceutical sciences 20110101

Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique.

Drug discoveries & therapeutics 20101201

Effects of diacerein at the molecular level in the osteoarthritis disease process.

Therapeutic advances in musculoskeletal disease 20100401

Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.

Osteoarthritis and cartilage 20100301

Effects of risedronate on osteoarthritis of the knee.

Yonsei medical journal 20100301

A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

Arthritis research & therapy 20100101

Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment.

Arthritis research & therapy 20100101

Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.

Arthritis research & therapy 20100101

Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study.

BMJ (Clinical research ed.) 20100101

Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.

Journal of young pharmacists : JYP 20100101

Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial.

Clinical rheumatology 20091001

Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation.

Fundamental & clinical pharmacology 20090801

Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study).

Joint, bone, spine : revue du rhumatisme 20090701

Physico-chemical and structural characterization of diacerhein.

Journal of pharmaceutical and biomedical analysis 20090501

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition.

Journal of molecular biology 20090424

Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Isolation and structural elucidation of two impurities from a diacerein bulk drug.

Journal of pharmaceutical and biomedical analysis 20090220

Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.

Osteoarthritis and cartilage 20090101

[Non-surgical treatment of osteoarthritis of large joints - new aspects].

Wiener medizinische Wochenschrift (1946) 20090101

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.

Scandinavian journal of rheumatology 20090101

The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study.

BMJ (Clinical research ed.) 20090101

Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.

Arthritis research & therapy 20090101

Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.

International journal of medical sciences 20090101

A stability-indicating high performance liquid chromatographic method for the determination of diacerein in capsules.

Indian journal of pharmaceutical sciences 20090101

A modified method for isolation of rhein from senna.

Indian journal of pharmaceutical sciences 20090101

[Treatment of osteoarthritis with drugs and other modalities].

Der Internist 20081201

Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.

Osteoarthritis and cartilage 20081001

Immune system and inflammation.

Indian journal of pharmacology 20081001

Prize sessions.

Indian journal of pharmacology 20081001

The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?

Pharmacological research 20080701

Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice.

International immunopharmacology 20080601

Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.

Rheumatology (Oxford, England) 20080501

[Effectiveness of drugs used in degenerative joint diseases (arthroses)].

Medicina clinica 20080405

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.

Osteoarthritis and cartilage 20080201

Intra-articular hyaluronic acid for treatment of osteoarthritis: a nationwide study among the older population of Taiwan.

BMC health services research 20080101

The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial.

BMC musculoskeletal disorders 20080101

In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.

Bio-medical materials and engineering 20080101

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.

Arthritis research & therapy 20080101

Clinical review of chondroitin sulfate in osteoarthritis.

Osteoarthritis and cartilage 20080101

Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.

Arthritis research & therapy 20080101

An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK).

Journal of the Indian Medical Association 20080101

Bioequivalence study of two capsule formulations containing diacerein 50 mg in healthy human subjects.

Arzneimittel-Forschung 20080101

In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.

Biorheology 20080101

P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis.

Journal of inflammation (London, England) 20080101

Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.

BMC musculoskeletal disorders 20080101

The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period.

Arthritis and rheumatism 20071201

[Review of the evidence about drugs used as SYSADOA].

Medicina clinica 20071103

Nutraceuticals in the management of osteoarthritis.

Orthopedics 20070801

The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study.

Osteoarthritis and cartilage 20070601

Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis.

Evidence-based medicine 20070601

Selection of reliable reference genes for qPCR studies on chondroprotective action.

BMC molecular biology 20070101

DMOAD developments: present and future.

Bulletin of the NYU hospital for joint diseases 20070101

A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria.

Arthritis research & therapy 20070101

Diacerhein versus glucosamine in a rat model of osteoarthritis.

Clinics (Sao Paulo, Brazil) 20061001

A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis.

Archives of internal medicine 20060925

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601

Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060601

[Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action].

Yao xue xue bao = Acta pharmaceutica Sinica 20060601

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort.

Annals of the rheumatic diseases 20060301

Diacerein for osteoarthritis.

The Cochrane database of systematic reviews 20060125

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.

Arthritis research & therapy 20060101

Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.

Biorheology 20060101

IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein.

Biorheology 20060101

The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.

Anesthesia and analgesia 20051201

Osteoarthritis: an overview of the disease and its treatment strategies.

Seminars in arthritis and rheumatism 20050801

[Pharmacological treatment of osteoarthritis. Expectations and reality].

Revista clinica espanola 20050401

Future treatment of osteoarthritis.

Orthopedics 20050201

Subjective impact of osteoarthritis flare-ups on patients' quality of life.

Health and quality of life outcomes 20050101

Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.

Arthritis research & therapy 20050101

Expedient total syntheses of rhein and diacerhein via Fries rearrangement.

The Journal of organic chemistry 20041210

Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis.

Annals of the rheumatic diseases 20041201

[Total hip arthroplasty indication, evaluation criteria for structure modifying trials. Lessons from the ECHODIAH and PHARE studies].

Presse medicale (Paris, France : 1983) 20040522

[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].

Presse medicale (Paris, France : 1983) 20040522

Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.

Osteoarthritis and cartilage 20040401

[Chondromodulation in 2003: dream or reality?].

Revue medicale de la Suisse romande 20040201

Measurement of structure (disease) modification in osteoarthritis.

Osteoarthritis and cartilage 20040101

Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.

Arthritis research & therapy 20040101

Similar group mean scores, but large individual variations, in patient-relevant outcomes over 2 years in meniscectomized subjects with and without radiographic knee osteoarthritis.

Health and quality of life outcomes 20040101

Diacerein has a structure/disease-modifying effect on hip osteoarthritis.

Clinical and experimental rheumatology 20040101

New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?

The Journal of rheumatology. Supplement 20030801

The true results of the ECHODIAH study with diacerein.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030501

Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.

Clinical and experimental rheumatology 20030101

Long-term treatment with diacerein has a structure/disease modifying effect on hip osteoarthritis.

Clinical and experimental rheumatology 20030101

[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].

Presse medicale (Paris, France : 1983) 20021207

[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model].

Presse medicale (Paris, France : 1983) 20021207

[Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making].

Presse medicale (Paris, France : 1983) 20021207

Oral and intra-articular remedies: Review of papers published from March 2001 to February 2002.

Current opinion in rheumatology 20020901

Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.

Matrix biology : journal of the International Society for Matrix Biology 20020801

Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption.

European journal of pharmacology 20020712

Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.

Pharmacology & toxicology 20020701

[Current therapeutic possibilities in the treatment of arthrosis].

La Revue du praticien 20020301

[Current medical possibilities in the treatment of arthrosis].

Presse medicale (Paris, France : 1983) 20020112

[Results of the ECHODIAH clinical trial on hip arthrosis].

Presse medicale (Paris, France : 1983) 20020112

In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein.

Biorheology 20020101

Diacerein as a disease-modulating agent in osteoarthritis.

Current rheumatology reports 20011201

Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.

Arthritis and rheumatism 20011101

Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Immunopharmacology and immunotoxicology 20011101

Pharmacological therapy of osteoarthritis.

Best practice & research. Clinical rheumatology 20011001

Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis.

European journal of pharmacology 20010511

A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis.

Osteoarthritis and cartilage 20010401

Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.

Osteoarthritis and cartilage 20010401

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.

The Journal of rheumatology 20010401

The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.

The Journal of rheumatology 20010401

Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects.

The Clinical journal of pain 20010301

Reports of equivalence trials should not mask negative or mediocre results.

Joint, bone, spine : revue du rhumatisme 20010301

[Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives].

Revue medicale de Liege 20010301

Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.

Japanese journal of pharmacology 20010101

[Case report of fatal hepatitis from diacerein].

Therapie 20010101

Effects of diacerein on indomethacin-induced gastric ulceration.

Pharmacology 20010101

Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.

Osteoarthritis and cartilage 20000501

Sleep attacks and Parkinson's disease treatment.

Lancet (London, England) 20000415

Clinical pharmacokinetics of diacerein.

Clinical pharmacokinetics 19981101

Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat.

The Journal of pharmacy and pharmacology 19880901