Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
| Title | Journal |
|---|---|
| Temporal changes in biological responses and uncertainty in assessing risks of endocrine-disrupting chemicals: insights from intensive time-course studies with fish. | Toxicological sciences : an official journal of the Society of Toxicology 20150401 |
| 17β-trenbolone, an anabolic-androgenic steroid as well as an environmental hormone, contributes to neurodegeneration. | Toxicology and applied pharmacology 20150101 |
| Expression of LH receptor in nonpregnant mouse endometrium: LH induction of 3β-HSD and de novo synthesis of progesterone. | The Journal of endocrinology 20121001 |
| Effects of fibroblast growth factor 9 (FGF9) on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells. | Endocrinology 20120901 |
| The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study. | Veterinary research communications 20120301 |
| Feline pituitary-dependent hyperadrenocorticism and insulin resistance due to a plurihormonal adenoma. | Topics in companion animal medicine 20120201 |
| Effects of nonylphenol on aldosterone release from rat zona glomerulosa cells. | Chemico-biological interactions 20120105 |
| The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels. | Neuropharmacology 20120101 |
| Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism. | Journal of veterinary internal medicine 20120101 |
| Pharmaceutical evaluation of compounded trilostane products. | Journal of the American Animal Hospital Association 20120101 |
| Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. | Journal of veterinary internal medicine 20120101 |
| Gh is produced by the testis of Japanese eel and stimulates proliferation of spermatogonia. | Reproduction (Cambridge, England) 20111201 |
| Transcriptional regulatory dynamics of the hypothalamic-pituitary-gonadal axis and its peripheral pathways as impacted by the 3-beta HSD inhibitor trilostane in zebrafish (Danio rerio). | Ecotoxicology and environmental safety 20110901 |
| Temporal evaluation of effects of a model 3β-hydroxysteroid dehydrogenase inhibitor on endocrine function in the fathead minnow. | Environmental toxicology and chemistry 20110901 |
| Decreased cytochrome c oxidase IV expression reduces steroidogenesis. | The Journal of pharmacology and experimental therapeutics 20110801 |
| Evaluation of twice-daily lower-dose trilostane treatment administered orally in dogs with naturally occurring hyperadrenocorticism. | Journal of the American Veterinary Medical Association 20110601 |
| Determination of the concentrations of trilostane and ketotrilostane that inhibit ex vivo canine adrenal gland synthesis of cortisol, corticosterone, and aldosterone. | American journal of veterinary research 20110501 |
| Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog. | Theriogenology 20110415 |
| Adrenocorticotropic hormone, but not trilostane, causes severe adrenal hemorrhage, vacuolization, and apoptosis in rats. | Domestic animal endocrinology 20110401 |
| Anti-ovulatory effects of RU486 and trilostane involve impaired cyclooxygenase-2 expression and mitotic activity of follicular granulosa cells in rats. | Prostaglandins & other lipid mediators 20110401 |
| The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors. | Psychopharmacology 20110301 |
| A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. | Journal of veterinary internal medicine 20110101 |
| Long-term efficacy of trilostane for Cushing's syndrome due to adrenocorticotropin-independent bilateral macronodular adrenocortical hyperplasia. | Internal medicine (Tokyo, Japan) 20110101 |
| Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. | The Journal of small animal practice 20101201 |
| Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells. | Cancer letters 20101128 |
| Prochloraz-induced oocyte maturation in rainbow trout (Oncorhynchus mykiss), a molecular and functional analysis. | Toxicological sciences : an official journal of the Society of Toxicology 20101101 |
| Evaluation of the use of baseline cortisol concentration as a monitoring tool for dogs receiving trilostane as a treatment for hyperadrenocorticism. | Journal of the American Veterinary Medical Association 20101001 |
| Aldosterone, hypertension and heart failure: insights from clinical trials. | Hypertension research : official journal of the Japanese Society of Hypertension 20100901 |
| 3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer. | Endocrinology 20100801 |
| The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis. | The Journal of steroid biochemistry and molecular biology 20100601 |
| Induction of progesterone receptor A form attenuates the induction of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. | Reproduction (Cambridge, England) 20100501 |
| Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. | The Journal of small animal practice 20100401 |
| Hypophysectomy for a dog with coexisting Cushing's disease and diabetes mellitus. | The Journal of veterinary medical science 20100301 |
| Trilostane in dogs. | The Veterinary clinics of North America. Small animal practice 20100301 |
| Effects of trilostane on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism. | Veterinary journal (London, England : 1997) 20100101 |
| Management of Cushing's syndrome in dogs. | The Veterinary record 20091024 |
| Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice. | Neuroreport 20090805 |
| The 3beta-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice. | Psychoneuroendocrinology 20090601 |
| Expression and regulation of tumor necrosis factor (TNF) and TNF-receptor family members in the macaque corpus luteum during the menstrual cycle. | Molecular reproduction and development 20090401 |
| Trilostane, FAD286, and the role of aldosterone in the central regulation of blood pressure: focus on 'Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats'. | American journal of physiology. Regulatory, integrative and comparative physiology 20090401 |
| Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells. | Molecular and cellular endocrinology 20090325 |
| The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum. | Molecular human reproduction 20090301 |
| Trilostane-induced inhibition of cortisol secretion results in reduced negative feedback at the hypothalamic-pituitary axis. | Domestic animal endocrinology 20090101 |
| Cushing's disease in dogs and humans. | Hormone research 20090101 |
| Urinary corticoid: creatinine ratios in dogs with pituitary-dependent hypercortisolism during trilostane treatment. | Journal of veterinary internal medicine 20090101 |
| Persistent isolated hypocortisolism following brief treatment with trilostane. | Australian veterinary journal 20081201 |
| Serum concentrations of cortisol and cortisone in healthy dogs and dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. | The Veterinary record 20081018 |
| Trilostane therapy for hyperadrenocorticism in three dogs with adrenocortical metastasis. | The Veterinary record 20080809 |
| Effects of a 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane, on the fathead minnow reproductive axis. | Toxicological sciences : an official journal of the Society of Toxicology 20080701 |
| Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane. | The Journal of steroid biochemistry and molecular biology 20080701 |
| Evaluation of twice-daily, low-dose trilostane treatment administered orally in dogs with naturally occurring hyperadrenocorticism. | Journal of the American Veterinary Medical Association 20080501 |
| Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice. | Pharmacology, biochemistry, and behavior 20080401 |
| The effect of trilostane treatment on circulating thyroid hormone concentrations in dogs with pituitary-dependent hyperadrenocorticism. | The Journal of small animal practice 20080301 |
| Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: case report. | The Journal of veterinary medical science 20080301 |
| Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain. | Journal of neurochemistry 20080101 |
| Comparison of non-selective adrenocorticolysis with mitotane or trilostane for the treatment of dogs with pituitary-dependent hyperadrenocorticism. | The Veterinary record 20071215 |
| Follicle-stimulating hormone induces spermatogenesis mediated by androgen production in Japanese eel, Anguilla japonica. | Biology of reproduction 20071201 |
| The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats. | The Journal of endocrinology 20070901 |
| Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. | Biochemistry 20070807 |
| Cushing's syndrome in a guinea pig. | The Veterinary record 20070623 |
| Changes of cytosol glucocorticoid receptor and renal Na(+)-K(+)-ATPase activity after swimming training in rat. | The Journal of sports medicine and physical fitness 20070601 |
| Evidence that the preovulatory rise in intrafollicular progesterone may not be required for ovulation in cattle. | The Journal of endocrinology 20070301 |
| Hyperadrenocorticism: treating dogs. | Compendium (Yardley, PA) 20070301 |
| Histological evaluation of the adrenal glands of seven dogs with hyperadrenocorticism treated with trilostane. | The Veterinary record 20070217 |
| Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane. | Clinical techniques in small animal practice 20070201 |
| Trilostane in advanced breast cancer. | Expert opinion on pharmacotherapy 20061201 |
| Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. | Naunyn-Schmiedeberg's archives of pharmacology 20061101 |
| Regulation of hepatic steroid receptors and enzymes by the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane. | The Journal of steroid biochemistry and molecular biology 20061001 |
| Relationship between the expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue. | Journal of animal science 20061001 |
| Update on drugs used to treat endocrine diseases in small animals. | The Veterinary clinics of North America. Small animal practice 20060901 |
| Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs. | The Veterinary record 20060826 |
| Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta. | The Journal of steroid biochemistry and molecular biology 20060801 |
| Cortisol, aldosterone, cortisol precursor, androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane. | Domestic animal endocrinology 20060701 |
| [Adrenocortical adenoma]. | Nihon rinsho. Japanese journal of clinical medicine 20060528 |
| In vitro effects of insulin-like growth factors and insulin on oocyte maturation and maturation-inducing steroid production in ovarian follicles of common carp, Cyprinus carpio. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20060501 |
| Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism. | Journal of the American Animal Hospital Association 20060101 |
| Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors. | Endocrinology 20051201 |
| Canine hyperadrenocorticism: effects of trilostane on parathyroid hormone, calcium and phosphate concentrations. | The Journal of small animal practice 20051101 |
| Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. | Veterinary clinical pathology 20050901 |
| Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. | The Journal of biological chemistry 20050603 |
| Labor induction abortion utilizing trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor. | Contraception 20050501 |
| Dynamic expression of caspase-2, -3, -8, and -9 proteins and enzyme activity, but not messenger ribonucleic acid, in the monkey corpus luteum during the menstrual cycle. | The Journal of clinical endocrinology and metabolism 20050401 |
| Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats. | Neuropharmacology 20050401 |
| Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat. | American journal of physiology. Regulatory, integrative and comparative physiology 20050201 |
| The use of trilostane for the treatment of alopecia X in Alaskan malamutes. | Journal of the American Animal Hospital Association 20050101 |
| A comparison of the survival times of dogs treated with mitotane or trilostane for pituitary-dependent hyperadrenocorticism. | Journal of veterinary internal medicine 20050101 |
| Treatment of canine Alopecia X with trilostane. | Veterinary dermatology 20041001 |
| Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticism. | American journal of veterinary research 20040901 |
| ADAMTS-1/METH-1 and TIMP-3 expression in the primate corpus luteum: divergent patterns and stage-dependent regulation during the natural menstrual cycle. | Molecular human reproduction 20040801 |
| Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. | The Journal of endocrinology 20040701 |
| Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism. | The Journal of small animal practice 20040601 |
| Trilostane treatment of bilateral adrenal enlargement and excessive sex steroid hormone production in a cat. | The Journal of small animal practice 20040501 |
| Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value. | Equine veterinary journal 20040401 |
| Adrenocorticotropic hormone levels in dogs with pituitary-dependent hyperadrenocorticism following trilostane therapy. | The Veterinary record 20040327 |
| Gonadotropin and steroid regulation of matrix metalloproteinases and their endogenous tissue inhibitors in the developed corpus luteum of the rhesus monkey during the menstrual cycle. | Biology of reproduction 20040101 |
| Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats. | Journal of veterinary internal medicine 20040101 |
| Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. | Journal of cellular biochemistry 20031215 |
| Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells. | Naunyn-Schmiedeberg's archives of pharmacology 20031201 |
| Trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. | Australian veterinary journal 20031001 |
| The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats. | Neuroendocrinology 20030701 |
| Use of trilostane for the treatment of pituitary-dependent hyperadrenocorticism in a cat. | The Journal of small animal practice 20030601 |
| Efficacy of trilostane for the treatment of equine Cushing's syndrome. | Equine veterinary journal 20030601 |
| 3 beta-hydroxysteroid dehydrogenase isomerase (3beta-HSD) activity in the rat sciatic nerve: kinetic analysis and regulation by steroids. | The Journal of steroid biochemistry and molecular biology 20030501 |
| Trilostane treatment of a dog with functional adrenocortical neoplasia. | The Journal of small animal practice 20030301 |
| Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve. | Journal of neurochemistry 20030101 |
| Exogenous steroid substrate modifies the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estradiol production of human luteinized granulosa cells in vitro. | Biology of reproduction 20030101 |
| Changes in ultrasonographic appearance of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. | Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20030101 |
| Medical treatment of hyperadrenocorticism in the dog. | Australian veterinary journal 20030101 |
| Effects of prostaglandins E2 and F2alpha (PGE2; PGF2alpha), trilostane, mifepristone, palmitic acid (PA), indomethacin (INDO), ethamoxytriphetol (MER-25), PGE2 + PA, or PGF2alpha + PA on PGE2, PGF2alpha, and progesterone secretion by bovine corpora lutea of mid-pregnancy in vitro. | The Chinese journal of physiology 20021231 |
| Non-competitive steroid inhibition of oestrogen receptor functions. | International journal of cancer 20020901 |
| Seasonal changes in plasma steroid levels in Indian major carp Labeo rohita: influence of homologous pituitary extract on steroid production and development of oocyte maturational competence. | General and comparative endocrinology 20020901 |
| Inhibition of testosterone production by propylthiouracil in rat Leydig cells. | Biology of reproduction 20020801 |
| Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism. | The Veterinary record 20020629 |
| Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials. | Human reproduction (Oxford, England) 20020601 |
| Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. | American journal of veterinary research 20020401 |
| Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020301 |
| [Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease]. | MMW Fortschritte der Medizin 20020227 |
| Cortisol/progesterone antagonism in regulation of 15-hydroxysteroid dehydrogenase activity and mRNA levels in human chorion and placental trophoblast cells at term. | The Journal of clinical endocrinology and metabolism 20020201 |
| Effects of indomethacin, luteinizing hormone (LH), prostaglandin E2 (PGE2), trilostane, mifepristone, ethamoxytriphetol (MER-25) on secretion of prostaglandin E (PGE), prostaglandin F2alpha (PGF2alpha) and progesterone by ovine corpora lutea of pregnancy or the estrous cycle. | Prostaglandins & other lipid mediators 20010301 |
| Inhibition of human placental progesterone synthesis and aromatase activity by synthetic steroidogenic inhibitors in vitro. | Fertility and sterility 19830601 |
| Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. | The Journal of clinical endocrinology and metabolism 19781101 |