O-(2-Acetamido-2-deoxy-d-glucopyranosylidene)amino n-phenyl carbamate
| Title | Journal |
|---|---|
| Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells. | Biological & pharmaceutical bulletin 20140101 |
| Computational analysis of human OGA structure in complex with PUGNAc and NAG-thiazoline derivatives. | Journal of chemical information and modeling 20121022 |
| Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. | The Journal of biological chemistry 20120706 |
| Beta-hexosaminidase activity of the oral pathogen Tannerella forsythia influences biofilm formation on glycoprotein substrates. | FEMS immunology and medical microbiology 20120601 |
| Glucosamine modulates TNF-α-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells. | Investigative ophthalmology & visual science 20120424 |
| PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells. | Journal of biochemistry 20120401 |
| Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis. | Biochemistry. Biokhimiia 20120201 |
| Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection. | PloS one 20120101 |
| Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases. | The Biochemical journal 20110915 |
| Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells. | Oncology reports 20110901 |
| O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP). | Biochemical and biophysical research communications 20110121 |
| O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells. | PloS one 20110101 |
| The role of O-linked GlcNAc modification on the glucose response of ChREBP. | Biochemical and biophysical research communications 20101126 |
| Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. | Glycobiology 20101001 |
| Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. | Chemistry & biology 20100924 |
| Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. | Nature chemical biology 20100901 |
| Cytoskeletal keratin glycosylation protects epithelial tissue from injury. | Nature cell biology 20100901 |
| Stressing the role of O-GlcNAc: linking cell survival to keratin modification. | Nature cell biology 20100901 |
| O-GlcNAc modification of proteins affects volume regulation in Jurkat cells. | European biophysics journal : EBJ 20100701 |
| An improved route to PUGNAc and its galacto-configured congener. | The Journal of organic chemistry 20100604 |
| Quantum mechanical/molecular mechanical molecular dynamics simulation of wild-type and seven mutants of CpNagJ in complex with PUGNAc. | The journal of physical chemistry. B 20100527 |
| Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. | ACS chemical biology 20100521 |
| Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. | Nature chemical biology 20100501 |
| Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. | Biochimica et biophysica acta 20100201 |
| O-linked beta-N-acetylglucosaminylation in mouse embryonic neural precursor cells. | Journal of neuroscience research 20091201 |
| O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Excessive O-GlcNAcylation of proteins suppresses spontaneous cardiogenesis in ES cells. | FEBS letters 20090806 |
| Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. | Protein science : a publication of the Protein Society 20090701 |
| O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program. | Developmental neurobiology 20090201 |
| Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury. | Circulation research 20090102 |
| O-linked beta-N-acetylglucosamine: a new piece of the cardioprotection puzzle? | Circulation research 20090102 |
| Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. | The Journal of biological chemistry 20081212 |
| A quantum mechanics/molecular mechanics study of the protein-ligand interaction of two potent inhibitors of human O-GlcNAcase: PUGNAc and NAG-thiazoline. | The journal of physical chemistry. B 20081113 |
| The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc. | Carbohydrate research 20081103 |
| Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury. | American journal of physiology. Heart and circulatory physiology 20080701 |
| O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene. | FEBS letters 20080305 |
| Proteomic analysis of O-GlcNAc modifications derived from streptozotocin and glucosamine induced beta-cell apoptosis. | Journal of biochemistry and molecular biology 20071130 |
| O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2. | Biochemical and biophysical research communications 20071019 |
| Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. | American journal of physiology. Heart and circulatory physiology 20070901 |
| The sweet nature of cardioprotection. | American journal of physiology. Heart and circulatory physiology 20070901 |
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. | The Journal of biological chemistry 20070720 |
| Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells. | Molecular and cellular biochemistry 20070401 |
| The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels. | Shock (Augusta, Ga.) 20070401 |
| Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. | Journal of the American Chemical Society 20070124 |
| Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor. | Chemical communications (Cambridge, England) 20061113 |
| Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1. | FEBS letters 20060529 |
| Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. | The EMBO journal 20060405 |
| An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety. | Journal of the American Chemical Society 20060405 |
| A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase. | Organic & biomolecular chemistry 20060307 |
| Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. | Bioorganic & medicinal chemistry 20060201 |
| O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. | Experimental & molecular medicine 20050630 |
| Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils. | The Journal of biological chemistry 20050415 |
| Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells. | Biochimica et biophysica acta 20050415 |
| Relationship between protein O-linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate. | Acta physiologica Scandinavica 20050301 |
| Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle. | Diabetes 20040401 |
| Cytosolic O-GlcNAc accumulation is not involved in beta-cell death in HIT-T15 or Min6. | Biochemical and biophysical research communications 20010921 |
| O-GlcNAc expression in developing and ageing mouse brain. | Biochimie 20010701 |