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Palifosfamide

CAS No.:
31645-39-3
Catalog Number:
AG000ZJN
Molecular Formula:
C4H11Cl2N2O2P
Molecular Weight:
221.0221
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%
1 week
United States
$473
- +
10mg
95%
1 week
United States
$657
- +
50mg
95%
1 week
United States
$1673
- +
Product Description
Catalog Number:
AG000ZJN
Chemical Name:
Palifosfamide
CAS Number:
31645-39-3
Molecular Formula:
C4H11Cl2N2O2P
Molecular Weight:
221.0221
MDL Number:
MFCD01705455
IUPAC Name:
bis(2-chloroethylamino)phosphinic acid
InChI:
InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
InChI Key:
BKCJZNIZRWYHBN-UHFFFAOYSA-N
SMILES:
ClCCNP(=O)(NCCCl)O
UNII:
6A4U6NN813
NSC Number:
297900
Properties
Complexity:
134  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
219.994g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
221.018g/mol
Monoisotopic Mass:
219.994g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
61.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.4  
Literature
Title Journal
Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys. Cancer chemotherapy and pharmacology 20120301
Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anti-cancer drugs 20120201
The effect of N-acetylcysteine on the antitumor activity of ifosfamide. Canadian journal of physiology and pharmacology 20110501
Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. Kidney international 20061101
[Identification of glufosfamide metabolites in rats]. Yao xue xue bao = Acta pharmaceutica Sinica 20060601
Comparative preclinical toxicology and pharmacology of isophosphoramide mustard, the active metabolite of ifosfamide. Cancer chemotherapy and pharmacology 20050201
1,3- vs 1,5-intramolecular alkylation reactions in isophosphoramide and phosphoramide mustards. Chemical research in toxicology 20040901
Phosphate prodrugs of isophosphoramide mustard. Acta poloniae pharmaceutica 20030101
Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy (GDEPT). Acta biochimica Polonica 20020101
Mechanisms of resistance against cyclophosphamide and ifosfamide: can they be overcome without sacrificing selectivity? Cancer treatment and research 20020101
Identification of new aqueous chemical degradation products of isophosphoramide mustard. Journal of pharmaceutical and biomedical analysis 20010601
Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma. Lancet (London, England) 19800927
Properties