Carbamic acid, N-(2-chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
| Title | Journal |
|---|---|
| Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. | Journal of medicinal chemistry 20130523 |
| The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice. | Obesity (Silver Spring, Md.) 20121001 |
| Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. | Chemistry & biology 20111028 |
| Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors. | Bioorganic & medicinal chemistry 20111015 |
| Temporal changes in microvessel leakiness during wound healing discriminated by in vivo fluorescence recovery after photobleaching. | The Journal of physiology 20111001 |
| Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. | Cancer science 20110801 |
| Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances. | Biomaterials 20110701 |
| Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells. | European journal of medicinal chemistry 20110401 |
| Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis. | The American journal of pathology 20110401 |
| Effect of nitroxoline on angiogenesis and growth of human bladder cancer. | Journal of the National Cancer Institute 20101215 |
| Inhibitory effects of TNP-470 in combination with BCNU on tumor growth of human glioblastoma xenografts. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20101201 |
| Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. | The Journal of pharmacology and experimental therapeutics 20100901 |
| Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells. | European journal of medicinal chemistry 20100601 |
| An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510. | Biochemical and biophysical research communications 20100108 |
| Broad spectrum antiangiogenic treatment for ocular neovascular diseases. | PloS one 20100101 |
| Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. | Molecular and biochemical parasitology 20091201 |
| Antiparasitic activities of novel, orally available fumagillin analogs. | Bioorganic & medicinal chemistry letters 20090901 |
| Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia. | Molecular vision 20090101 |
| TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity. | Bioorganic & medicinal chemistry 20080815 |
| An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. | Nature biotechnology 20080701 |
| Anti-tumor effect of angiogenesis inhibitor TNP-470 and 5-FU combined therapy on human gastric cancer xenograft. | Hepato-gastroenterology 20080101 |
| The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumor angiogenesis. | Anticancer research 20080101 |
| Judah Folkman's contribution to the inhibition of angiogenesis. | Lymphatic research and biology 20080101 |
| Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. | Cancer research 20071001 |
| Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma. | Translational research : the journal of laboratory and clinical medicine 20070901 |
| Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. | Journal of medicinal chemistry 20070809 |
| Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters. | Archivum immunologiae et therapiae experimentalis 20070801 |
| Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis. | Nature clinical practice. Rheumatology 20070801 |
| Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. | Expert review of anti-infective therapy 20070801 |
| Antitumor effect of TNP-470, an angiogenesis inhibitor, combined with ultrasound irradiation for human uterine sarcoma xenografts evaluated using contrast color Doppler ultrasound. | Cancer science 20070601 |
| Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer. | Molecular cancer therapeutics 20070401 |
| Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. | Journal of molecular endocrinology 20070401 |
| Genetic analysis of high-metastatic clone of RCT sarcoma in mice, and its growth regression in vivo in response to angiogenesis inhibitor TNP-470. | Journal of experimental & clinical cancer research : CR 20070301 |
| Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. | Translational research : the journal of laboratory and clinical medicine 20070101 |
| Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine. | Journal of Zhejiang University. Science. B 20061001 |
| Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo. | Journal of medicinal chemistry 20060921 |
| A noncanonical path to mechanism of action. | Chemistry & biology 20060901 |
| A chemical and genetic approach to the mode of action of fumagillin. | Chemistry & biology 20060901 |
| Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. | FEBS letters 20060515 |
| TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells. | Biochemical and biophysical research communications 20060303 |
| Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470. | Asian Pacific journal of cancer prevention : APJCP 20060101 |
| The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470. | Cellular & molecular biology letters 20060101 |
| Combination therapy with tumor-lysate pulsed dendritic cells and antiangiogenic drug TNP-470 for mouse pancreatic cancer. | International journal of cancer 20051110 |
| Antiangiogenic drugs for chemotherapy of bladder tumours. | Chemotherapy 20051001 |
| A novel mechanism of action of the fumagillin analog, TNP-470, in the B16F10 murine melanoma cell line. | Anti-cancer drugs 20050901 |
| Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol. | Bioorganic & medicinal chemistry letters 20050801 |
| Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050801 |
| Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model. | International journal of cancer 20050310 |
| Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and docetaxel in a human prostate cancer PC-3 model. | International journal of oncology 20050301 |
| Antiangiogenic strategies in neuroblastoma. | Cancer treatment reviews 20050201 |
| Inhibition of tumor angiogenesis during cisplatin chemotherapy for bladder cancer improves treatment outcome. | Urology 20050201 |
| Acceleration of follicular development by administration of vascular endothelial growth factor in cycling female rats. | The Journal of reproduction and development 20050201 |
| Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice. | World journal of gastroenterology 20050121 |
| Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF production. | Anticancer research 20050101 |
| Pharmacokinetic model-predicted anticancer drug concentrations in human tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041201 |
| TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy. | Transplantation 20041027 |
| Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model. | The Journal of urology 20041001 |
| TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. | Kidney international 20041001 |
| Participation of cyclin D1 deregulation in TNP-470-mediated cytostatic effect: involvement of senescence. | Biochemical pharmacology 20040815 |
| Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. | Circulation research 20040625 |
| A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. | Oncology reports 20040501 |
| A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases. | The Journal of biological chemistry 20040305 |
| Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. | Nature medicine 20040301 |
| TNP-470 promotes initial vascular sprouting in xenograft tumors. | Molecular cancer therapeutics 20040301 |
| cis-Diamminedichloroplatinum-resistant cell lines derived from human epithelial ovarian carcinoma express increased susceptibility to angiogenesis inhibitor TNP-470. | Gynecologic oncology 20040201 |
| Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. | Archives of pharmacal research 20040201 |
| Carcinosarcoma-induced endothelial cells tube formation through KDR/Flk-1 is blocked by TNP-470. | Cancer letters 20040108 |
| Investigation of novel fumagillin analogues as angiogenesis inhibitors. | Bioorganic & medicinal chemistry letters 20040105 |
| Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis. | Angiogenesis 20040101 |
| Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2). | Angiogenesis 20040101 |
| The combination of antiangiogenic and cytotoxic agents in the treatment of prostate cancer. | Clinical prostate cancer 20031201 |
| Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. | Cancer research 20031115 |
| [Systemic treatment for hepatocellular carcinoma]. | Zentralblatt fur Chirurgie 20031101 |
| Changes in tumor vascularization after irradiation, anthracyclin, or antiangiogenic treatment in nitrosomethyl ureas-induced rat mammary tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20031001 |
| Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin. | Cancer research 20031001 |
| Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice. | Fertility and sterility 20030901 |
| Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design. | Biophysical chemistry 20030801 |
| TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma. | Free radical research 20030801 |
| Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. | The Journal of clinical investigation 20030701 |
| TNP-470 inhibits 7,12-dimethylbenz[a]anthracene-induced mammary tumor formation when administered before the formation of carcinoma in situ but is not additive with tamoxifen. | Laboratory investigation; a journal of technical methods and pathology 20030701 |
| Angiogenesis inhibitor TNP-470 (AGM-1470) suppresses vascular smooth muscle cell proliferation after balloon injury in rats. | The Journal of surgical research 20030615 |
| 'Vasocrine' formation of tumor cell-lined vascular spaces: implications for rational design of antiangiogenic therapies. | Cancer research 20030601 |
| Effect of angiogenesis inhibitor TNP-470 on the growth, blood flow, and microvessel density in xenografts of human uterine carcinosarcoma in nude mice. | Gynecologic oncology 20030401 |
| Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma. | Pancreas 20030301 |
| Preparation of poly-lactic acid microspheres containing the angiogenesis inhibitor TNP-470 with medium-chain triglyceride and the in vitro evaluation of release profiles. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030301 |
| Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. | Chirality 20030201 |
| In vivo chamber angiogenesis assay: an optimized Matrigel plug assay for fast assessment of anti-angiogenic activity. | International journal of oncology 20030201 |
| Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies. | The Journal of pharmacology and experimental therapeutics 20030201 |
| Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030201 |
| [Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer]. | Ai zheng = Aizheng = Chinese journal of cancer 20021201 |
| [Experimental therapy with angiogenesis inhibitor TNP-470 on human ovarian cancer transplanted subcutaniously in nude mice]. | Zhonghua fu chan ke za zhi 20020901 |
| Enhanced suppression of prostate tumor growth by combining C-CAM1 gene therapy and angiogenesis inhibitor TNP-470. | Anti-cancer drugs 20020801 |
| Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice. | Journal of cancer research and clinical oncology 20020801 |
| Angiogenesis inhibitors in lung cancer. | Current oncology reports 20020701 |
| Novel bicyclic oxazolone derivatives as anti-angiogenic agents. | Bioorganic & medicinal chemistry letters 20020603 |
| Angiogenesis in bladder cancer--prognostic marker and target for future therapy. | Surgical oncology 20020601 |
| Antitumor effect of TNP-470 is not associated to decrease of angiogenesis in an experimental malignant neuroectodermic tumor. | Journal of neuro-oncology 20020601 |
| CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs. | Pediatric research 20020501 |
| Assay of TNP-470 and its two major metabolites in human plasma by high-performance liquid chromatography-mass spectrometry. | Journal of chromatographic science 20020401 |
| Injection of antiangiogenic agents into the macaque preovulatory follicle: disruption of corpus luteum development and function. | Endocrine 20020401 |
| Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis. | Journal of biomedical science 20020101 |
| [Human microsporidiosis]. | Klinische Padiatrie 20020101 |
| The role of growth factors, angiogenic enzymes and apoptosis in neovascularization and tumor growth-collected publications. | Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20020101 |
| TNP-470 combined with nicardipine suppresses in vivo growth of PC-3, a human prostate cancer cell line. | Urologic oncology 20020101 |
| QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: another example of an allosteric interaction. | Bioorganic & medicinal chemistry 20011201 |
| TNP-470 reduces collagen and macrophage accumulation in expanded polytetrafluoroethylene tube implants. | The Journal of surgical research 20011101 |
| A potential use of a synthetic retinoid TAC-101 as an orally active agent that blocks angiogenesis in liver metastases of human stomach cancer cells. | Japanese journal of cancer research : Gann 20011101 |
| Drug targeting to choroidal neovascularization. | Advanced drug delivery reviews 20011031 |
| Inhibition of inflammatory corneal angiogenesis by TNP-470. | Investigative ophthalmology & visual science 20011001 |
| The inhibitory effects of TNP470 on tumour growth of head and neck carcinoma cell producing interleukin-8. | The Journal of laryngology and otology 20011001 |
| Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470. | Cancer research 20010715 |
| Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010501 |
| General aspects of anti-angiogenesis and cancer therapy. | Expert opinion on biological therapy 20010301 |
| In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment. | International journal of radiation oncology, biology, physics 20010201 |
| Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes. | Cancer investigation 20010101 |
| Regulation and action of angiogenic factors in the primate ovary. | Archives of medical research 20010101 |
| Treatment of tamoxifen-refractory breast cancer--approach by animal models. | Breast cancer (Tokyo, Japan) 20010101 |
| A re-evaluation of fumagillin selectivity towards endothelial cells. | Anticancer research 20010101 |
| Microsporidian methionine aminopeptidase type 2. | The Journal of eukaryotic microbiology 20010101 |
| In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies. | The Journal of eukaryotic microbiology 20010101 |
| Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide. | Anticancer research 20010101 |
| Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. | Cancer research 20000401 |
| TNP-470 is an effective antimicrosporidial agent. | The Journal of infectious diseases 19980201 |
| Screening of compounds for antimicrosporidial activity in vitro. | Folia parasitologica 19980101 |
| Effects of albendazole, fumagillin, and TNP-470 on microsporidial replication in vitro. | Antimicrobial agents and chemotherapy 19970701 |
| Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. | Nature 19901206 |