Home Aminos (2R,3R)-2,3-dihydroxybutanedioic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate

(2R,3R)-2,3-dihydroxybutanedioic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate

CAS No.:
129101-54-8
Catalog Number:
AG000YUP
Molecular Formula:
C18H28N2O8
Molecular Weight:
400.4235
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$63
- +
5g
97%
In Stock USA
United States
$188
- +
10g
97%
In Stock USA
United States
$300
- +
25g
97%
In Stock USA
United States
$563
- +
Product Description
Catalog Number:
AG000YUP
Chemical Name:
(2R,3R)-2,3-dihydroxybutanedioic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate
CAS Number:
129101-54-8
Molecular Formula:
C18H28N2O8
Molecular Weight:
400.4235
MDL Number:
MFCD03700731
IUPAC Name:
(2R,3R)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
InChI:
InChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
InChI Key:
GWHQHAUAXRMMOT-MBANBULQSA-N
SMILES:
OC(=O)[C@@H]([C@H](C(=O)O)O)O.CCN(C(=O)Oc1cccc(c1)[C@@H](N(C)C)C)C
EC Number:
603-318-3
UNII:
9IY2357JPE
Properties
Complexity:
402  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
400.185g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
400.428g/mol
Monoisotopic Mass:
400.185g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
148A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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Acteylcholinesterase inhibitor rivastigmine enhances cellular defenses in neuronal and macrophage-like cell lines. Translational research : the journal of laboratory and clinical medicine 20090301
Effects of cholinesterase inhibition on brain white matter volume in Alzheimer's disease. Neuroreport 20090218
BuChE-K and APOE epsilon4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline. Movement disorders : official journal of the Movement Disorder Society 20090215
Top cited papers in International Psychogeriatrics: 1. Long-term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial. International psychogeriatrics 20090201
Simultaneous determination of galantamine, rivastigmine and NAP 226-90 in plasma by MEKC and its application in Alzheimer's disease. Electrophoresis 20090201
Long-term effects of rivastigmine capsules in patients with traumatic brain injury. Brain injury 20090201
Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients. Current Alzheimer research 20090201
Adherence to cholinesterase inhibitors in patients with Alzheimer's disease. Journal of the American Geriatrics Society 20090201
Rivastigmine for dementia in people with Down syndrome. The Cochrane database of systematic reviews 20090121
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions. The Biochemical journal 20090101
Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine. Psychopharmacology 20090101
Improvement of spontaneous speech in early stage Alzheimer's with rivastigmine. The journal of nutrition, health & aging 20090101
[The role of rivastigmine (exelon) in the treatment of consequences of cranial-brain trauma]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101
[Transdermal rivastigmine patch in outpatient services in Austria: a naturalistic study in 103 patients with Alzheimer dementia]. Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20090101
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. Journal of Alzheimer's disease : JAD 20090101
Switching from donepezil tablets to rivastigmine transdermal patch in Alzheimer's disease. American journal of Alzheimer's disease and other dementias 20090101
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101
Safety and tolerability of the rivastigmine patch: results of a 28-week open-label extension. Alzheimer disease and associated disorders 20090101
Persistence with cholinesterase inhibitor therapy for dementia: an observational administrative health database study. Drugs & aging 20090101
[Results of the open multicenter prospective study of safety and tolerability of rivastigmine (exelon) in different titration regimes in mild and moderate Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101
Current treatments of Alzheimer disease: are main caregivers satisfied with the drug treatments received by their patients? Dementia and geriatric cognitive disorders 20090101
Neurometabolic correlations of donepezil and rivastigmine in dementia patients: a different neuroprotective effect. The Journal of neuropsychiatry and clinical neurosciences 20090101
Safety/Tolerability and efficacy of rivastigmine in taiwanese patients with Alzheimer's disease: a prospective post-marketing surveillance study. Clinical drug investigation 20090101
Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer's disease: systematic review of the 'real-world' evidence. Dementia and geriatric cognitive disorders 20090101
Gender differences in the pharmacokinetics of rivastigmine in rats. Arzneimittel-Forschung 20090101
Predictors of long-term treatment effect of rivastigmine in Alzheimer's disease: a role for beta-amyloid plasma levels? Neurologia i neurochirurgia polska 20090101
Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease. Expert opinion on drug delivery 20081201
Brain cholinergic impairment in liver failure. Brain : a journal of neurology 20081101
Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. Journal of neuroimmunology 20081015
Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro. Journal of neural transmission (Vienna, Austria : 1996) 20081001
Pharmacological treatment in moderate-to-severe Alzheimer's disease. Expert opinion on pharmacotherapy 20081001
Evaluation of the cardiovascular and subjective effects of rivastigmine in combination with methamphetamine in methamphetamine-dependent human volunteers. The international journal of neuropsychopharmacology 20080901
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. Current medical research and opinion 20080901
[Alzheimer type dementia]. Revue de l'infirmiere 20080901
Effects of rivastigmine on memory and cognition in multiple sclerosis. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080901
Drug utilization review of cholinesterase inhibitors in Quebec. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080901
[A transdermal patch of rivastigmine (Exelon)]. Revue medicale de Liege 20080901
A study of rivastigmine liposomes for delivery into the brain through intranasal route. Acta pharmaceutica (Zagreb, Croatia) 20080901
Rivastigmine versus placebo in hyperhomocysteinemic Parkinson's disease dementia patients. Movement disorders : official journal of the Movement Disorder Society 20080815
Rivastigmine in Parkinson's disease dementia. Expert review of neurotherapeutics 20080801
Rivastigmine transdermal patch: role in the management of Alzheimer's disease. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080801
Prevalence of cholinesterase inhibitors in subjects with dementia in Europe. Pharmacoepidemiology and drug safety 20080701
Rivastigmine effects on EEG spectra and three-dimensional LORETA functional imaging in Alzheimer's disease. Psychopharmacology 20080601
Complete atrioventricular block associated with rivastigmine therapy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080601
Miniaturized membrane sensors for the determination of rivastigmine hydrogen tartrate. Chemical & pharmaceutical bulletin 20080601
Comparison of cholinesterase inhibitor utilization patterns and associated health care costs in Alzheimer's disease. Journal of managed care pharmacy : JMCP 20080601
[A comparative study of the effectiveness and tolerability of a procedure involving slow dose-escalation of rivastigmine in patients with mild or moderate Alzheimer-type dementia: the SCALEX study]. Revista de neurologia 20080501
Dementia medications in palliative care #174. Journal of palliative medicine 20080501
[Treatment of Alzheimer's disease: status quo and future considerations]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080501
Parkinson's disease in the elderly. Medicine and health, Rhode Island 20080501
Diagnosis and treatment of dementia with Lewy bodies. JAAPA : official journal of the American Academy of Physician Assistants 20080501
AAFP and ACP release guideline on dementia treatment. American family physician 20080415
In situ-forming oleogel implant for rivastigmine delivery. Pharmaceutical research 20080401
Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080401
The acetylcholinesterase inhibitor rivastigmine does not alter total choices for methamphetamine, but may reduce positive subjective effects, in a laboratory model of intravenous self-administration in human volunteers. Pharmacology, biochemistry, and behavior 20080401
A rivastigmine patch for dementia. The Medical letter on drugs and therapeutics 20080324
Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease. Brain research 20080320
A nanoparticulate drug-delivery system for rivastigmine: physico-chemical and in vitro biological characterization. Macromolecular bioscience 20080310
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations. Annals of internal medicine 20080304
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Annals of internal medicine 20080304
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Annals of internal medicine 20080304
Olanzapine-associated neuroleptic malignant syndrome in a patient receiving concomitant rivastigmine therapy. Pharmacotherapy 20080301
Microcalorimetric study of the inhibition of butyrylcholinesterase by carbamates. Analytical biochemistry 20080215
Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. International journal of geriatric psychiatry 20080201
A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. International journal of geriatric psychiatry 20080201
Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retention. International journal of geriatric psychiatry 20080201
Neurological signs in relation to type of cerebrovascular disease in vascular dementia. Stroke 20080201
Pharmacokinetics and bioavailability of the novel rivastigmine transdermal patch versus rivastigmine oral solution in healthy elderly subjects. Journal of clinical pharmacology 20080201
Pharmacologic management of Alzheimer disease. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20080201
[Cholinesterase inhibitors in the treatment of dementia--are they useful in clinical practice?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080131
Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients. Clinical pharmacology and therapeutics 20080101
[Therapy of cognitive deficits in schizophrenia with acetylcholinesterase inhibitors. A systematic overview]. Der Nervenarzt 20080101
Rivastigmine in Wernicke-Korsakoff's syndrome: five patients with rivastigmine showed no more improvement than five patients without rivastigmine. Alcohol and alcoholism (Oxford, Oxfordshire) 20080101
Identification of responders to rivastigmine: a prospective cohort study. Dementia and geriatric cognitive disorders 20080101
A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders. Current medical research and opinion 20080101
Effects of rivastigmine on tremor and other motor symptoms in patients with Parkinson's disease dementia: a retrospective analysis of a double-blind trial and an open-label extension. Drug safety 20080101
Different responses to rivastigmine in subcortical vascular dementia and multi-infarct dementia. American journal of Alzheimer's disease and other dementias 20080101
Estimated pre-morbid IQ effects on cognitive and functional outcomes in Alzheimer disease: a longitudinal study in a treated cohort. BMC psychiatry 20080101
Steady-state pharmacokinetics of rivastigmine in patients with mild to moderate Alzheimer's disease not affected by co-administration of memantine: an open-label, crossover, single-centre study. Clinical drug investigation 20080101
Impact of rivastigmine on caregiver burden associated with Alzheimer's disease in both informal care and nursing home settings. Drugs & aging 20080101
Fluorimetric determination of rivastigmine in rat plasma by a reverse phase--high performance liquid chromatographic method. Application to a pharmacokinetic study. Arzneimittel-Forschung 20080101
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. Clinical interventions in aging 20080101
A pilot study of rivastigmine in the treatment of delirium after stroke: a safe alternative. BMC neurology 20080101
[The treatment of Alzheimer's disease in patients with comorbid somatic pathology]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
Student pharmacists: don't forget the product labeling. Journal of the American Pharmacists Association : JAPhA 20080101
A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy. Arzneimittel-Forschung 20080101
Discontinuing Alzheimer's disease drug therapy: why, when, and how. Director (Cincinnati, Ohio) 20080101
Focusing effect of acetylcholine on neuroplasticity in the human motor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20071226
Rivastigmine exposure provided by a transdermal patch versus capsules. Current medical research and opinion 20071201
Rivastigmine-induced dystonia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071201
Risperidone, olanzapine and quetiapine in the treatment of behavioral and psychological symptoms in patients with Alzheimer's disease: preliminary findings from a naturalistic, retrospective study. Psychiatry and clinical neurosciences 20071201
[Rivastigmine against dementia in Parkinson disease?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20071115
A rivastigmine patch for the treatment of Alzheimer's disease and Parkinson's disease dementia. Expert review of neurotherapeutics 20071101
N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. European journal of pharmacology 20071031
Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry 20071001
Subthreshold depression in patients with Parkinson's disease and dementia--clinical and demographic correlates. International journal of geriatric psychiatry 20071001
[Lewy body dementia and Parkinson disease dementia]. Presse medicale (Paris, France : 1983) 20071001
Patient and caregiver outcomes after 6 +/- 1.5-months of rivastigmine therapy for mild-to-moderate Alzheimer's disease: the Belgian FExT study. Current medical research and opinion 20071001
Evaluation of centrally acting cholinesterase inhibitor exposures in adults. The Annals of pharmacotherapy 20071001
Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial. Journal of clinical psychopharmacology 20071001
Cholinergic balance in dementia with Lewy bodies: reversible worsening of Parkinsonism at rivastigmine dosage modulation. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20071001
Diagnosis and management of vascular cognitive impairment. Current atherosclerosis reports 20071001
[Are anti-dementia drugs worthwhile?]. MMW Fortschritte der Medizin 20070913
Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis. International journal of geriatric psychiatry 20070901
Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. The Lancet. Neurology 20070901
NICE judgement leaves behind a nasty taste. Nursing older people 20070901
Pharmacokinetic rationale for the rivastigmine patch. Neurology 20070724
IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease. Neurology 20070724
Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease. Neurology 20070724
Impairment of nonverbal recognition in Alzheimer disease: a PET O-15 study. Neurology 20070703
Rivastigmine in dementia associated with Parkinson's disease and Alzheimer's disease: similarities and differences. Journal of Alzheimer's disease : JAD 20070701
A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the estimation of rivastigmine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Molecular pharmacology 20070601
Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future. International psychogeriatrics 20070601
EXACT: rivastigmine improves the high prevalence of attention deficits and mood and behaviour symptoms in Alzheimer's disease. International journal of clinical practice 20070601
MCI treatment trials: failure or not? The Lancet. Neurology 20070601
Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. The Lancet. Neurology 20070601
[Cholinesterase inhibitors and Alzheimer's disease: meta-analysis of the verification of effectiveness, origin and bias of results in published studies]. Deutsche medizinische Wochenschrift (1946) 20070601
[Rivastigmine solution prescribing habits in patients with Alzheimer-type dementia in Spain (RIVASOL study)]. Revista de neurologia 20070601
Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease. Drugs of today (Barcelona, Spain : 1998) 20070601
[Acetylcholinesterase inhibitors for dementia--an update]. MMW Fortschritte der Medizin 20070521
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. Neurology 20070515
Effects of rivastigmine on cognitive function in patients with traumatic brain injury. Neurology 20070515
Identification of responders and reactive domains to rivastigmine in Alzheimer's disease. Pharmacoepidemiology and drug safety 20070501
Changes in brain 11C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET. Psychopharmacology 20070501
A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule. International journal of geriatric psychiatry 20070501
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences 20070501
Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease. International journal of geriatric psychiatry 20070501
[Hallucinations associated to treatment with rivastigmine in two patients with diffuse Lewy body disease]. Revista de neurologia 20070501
Cholinesterase inhibitor treatment and urinary incontinence in Alzheimer's disease. Journal of the American Geriatrics Society 20070501
Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International journal of geriatric psychiatry 20070401
Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled study. International journal of geriatric psychiatry 20070401
Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application. Journal of clinical pharmacology 20070401
Rivastigmine and Parkinson dementia complex. Expert opinion on pharmacotherapy 20070401
Modulation of human motor cortex excitability by the cholinesterase inhibitor rivastigmine. Neuroscience letters 20070319
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease. Journal of the American Medical Directors Association 20070301
Rivastigmine treatment as an add-on to antipsychotics in patients with schizophrenia and cognitive deficits. Current medical research and opinion 20070301
Rivastigmine in the treatment of Alzheimer's disease: an update. Clinical interventions in aging 20070301
[Synthesis of S-(+)-rivastigmine hydrogentartrate]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070201
Effects of rivastigmine on actigraphically monitored motor activity in severe agitation related to Alzheimer's disease: a placebo-controlled pilot study. Archives of gerontology and geriatrics 20070101
Strategies to improve tolerability of rivastigmine: a case series. Current medical research and opinion 20070101
Two years' follow-up of rivastigmine treatment in Huntington disease. Clinical neuropharmacology 20070101
Evaluation of the slopes of cognitive impairment and disability in Alzheimer's disease (AD) patients treated with acetylcholinesterase inhibitors (AChEl). Archives of gerontology and geriatrics 20070101
Domain-specific improvement of cognition on memantine in patients with Alzheimer's disease treated with rivastigmine. Dementia and geriatric cognitive disorders 20070101
Rivastigmine in Parkinson's disease dementia: profile report. Drugs & aging 20070101
Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: a case control study. American journal of Alzheimer's disease and other dementias 20070101
[Transdermal drugs in neurology]. Neurologia (Barcelona, Spain) 20070101
Parkinson's disease-related visual hallucinations unresponsive to atypical antipsychotics treated with cholinesterase inhibitors: a case series. Neurologia i neurochirurgia polska 20070101
Domperidone is effective in the prevention of rivastigmine-related gastrointestinal disturbances. Functional neurology 20070101
Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Pharmacological reports : PR 20070101
Effect of rivastigmine on regional cerebral blood flow in Alzheimer's disease. Advances in therapy 20070101
Comparing treatment effects in a clinical sample of patients with probable Alzheimer's disease treated with two different cholinesterase inhibitors. Acta bio-medica : Atenei Parmensis 20070101
Plasma Abeta levels as predictors of response to rivastigmine treatment in Alzheimer's disease. Acta neurobiologiae experimentalis 20070101
Modelling disease progression in Alzheimer's disease: a review of modelling methods used for cost-effectiveness analysis. PharmacoEconomics 20070101
Rivastigmine transdermal patch: in the treatment of dementia of the Alzheimer's type. CNS drugs 20070101
Drug interactions with cholinesterase inhibitors: an analysis of the French pharmacovigilance database and a comparison of two national drug formularies (Vidal, British National Formulary). Drug safety 20070101
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. Current medicinal chemistry 20070101
Neuropsychological rehabilitation in mild and moderate Alzheimer's disease patients. Behavioural neurology 20070101
The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor. British journal of pharmacology 20061201
[Diagnosis and clinical therapy for Parkinson's disease]. Der Nervenarzt 20061201
Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study. Journal of child and adolescent psychopharmacology 20061201
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters 20061115
Brain perfusion effects of cholinesterase inhibitors in Parkinson's disease with dementia. Journal of neural transmission (Vienna, Austria : 1996) 20061101
Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20061101
Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease. Pharmacogenetics and genomics 20061101
A large, naturalistic, community-based study of rivastigmine in mild-to-moderate AD: the EXTEND Study. Current medical research and opinion 20061101
Cognitive dysfunctions in schizophrenia: potential benefits of cholinesterase inhibitor adjunctive therapy. Journal of psychiatry & neuroscience : JPN 20061101
[Medical treatment of Alzheimer's disease]. Ugeskrift for laeger 20061002
Effect of rivastigmine on tremor in patients with Parkinson's disease and dementia. Movement disorders : official journal of the Movement Disorder Society 20061001
[Retrospective comparative analysis of antidementia medication persistence patterns in Spanish Alzheimer's disease patients treated with donepezil, rivastigmine, galantamine and memantine]. Revista de neurologia 20061001
Use of antidementia agents in vascular dementia: beyond Alzheimer disease. Mayo Clinic proceedings 20061001
Unsubstantiated superiority claims for rivastigmine tartrate. The Journal of the American Osteopathic Association 20061001
Effects of rivastigmine on cognitive function in patients with traumatic brain injury. Neurology 20060912
Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats. Acta pharmacologica Sinica 20060901
Do caregivers' experiences correspond with the concerns raised in the literature? Ethical issues relating to anti-dementia drugs. International journal of geriatric psychiatry 20060901
Utility of the Mattis dementia rating scale to assess the efficacy of rivastigmine in dementia associated with Parkinson's disease. Journal of neurology 20060901
[Advances in Alzheimer's disease treatment]. La Revue de medecine interne 20060801
[Cholinesterase inhibitor therapy in long term care settings]. La Revue de medecine interne 20060801
Alzheimer's disease. Lancet (London, England) 20060729
Are cholinergic enhancers beneficial for memory in schizophrenia? An event-related potentials (ERPs) study of rivastigmine add-on therapy in a crossover trial. Progress in neuro-psychopharmacology & biological psychiatry 20060701
Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind investigation. Schizophrenia research 20060701
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701
[Rivastigmine as adjunctive therapy in the therapeutic dilemma for the treatment of hallucinations due to Parkinson disease]. Tijdschrift voor gerontologie en geriatrie 20060701
Antipsychotic drug use among nursing home residents taking rivastigmine. Journal of the American Medical Directors Association 20060601
Cardiac safety of rivastigmine in Lewy body and Parkinson's disease dementias. International journal of clinical practice 20060601
Treatment effects of rivastigmine on cognition, performance of daily living activities and behaviour in Alzheimer's disease in an outpatient geriatric setting. International journal of clinical practice 20060601
Patterns of cholinesterase-inhibitor use in the nursing home setting: a retrospective analysis. The American journal of geriatric pharmacotherapy 20060601
Long-term benefits of rivastigmine in dementia associated with Parkinson's disease: an active treatment extension study. Movement disorders : official journal of the Movement Disorder Society 20060401
Clinical trials in mild cognitive impairment: lessons for the future. Journal of neurology, neurosurgery, and psychiatry 20060401
Pharmacological manipulation of the vasoconstrictive effects of amyloid-beta peptides by donepezil and rivastigmine. Current Alzheimer research 20060401
Beneficial effect of cholinesterase inhibitor medications on recognition memory performance in mild to moderate Alzheimer's disease: preliminary findings. Journal of geriatric psychiatry and neurology 20060301
Longitudinal observational studies to study the efficacy-effectiveness gap in drug therapy: application to mild and moderate dementia. The Nursing clinics of North America 20060301
Appeals system and its outcomes in national health insurance in Taiwan. The Annals of pharmacotherapy 20060301
Effect of age on response to rivastigmine or donepezil in patients with Alzheimer's disease. Current medical research and opinion 20060301
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus. Brain research 20060216
Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996) 20060201
Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission. Mechanisms of ageing and development 20060201
Quetiapine and rivastigmine for agitation in Alzheimer's disease. Current psychiatry reports 20060201
Cholinesterase inhibitors for Parkinson's disease dementia. The Cochrane database of systematic reviews 20060125
Cholinesterase inhibitors for Alzheimer's disease. The Cochrane database of systematic reviews 20060125
Neural correlates of adjunctive rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind fMRI study. NeuroImage 20060115
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. International journal of geriatric psychiatry 20060101
Alarming arbitrariness in EU prescription and reimbursement criteria for anti-dementia drugs. International journal of geriatric psychiatry 20060101
Case of the month: rivastigmine (Exelon) toxicity with evidence of respiratory depression. Emergency medicine journal : EMJ 20060101
Circadian cholinergic rhythms: implications for cholinesterase inhibitor therapy. Dementia and geriatric cognitive disorders 20060101
Response to rivastigmine or donepezil in Alzheimer's patients with symptoms suggestive of concomitant Lewy body pathology. Current medical research and opinion 20060101
Rivastigmine monotherapy and combination therapy with memantine in patients with moderately severe Alzheimer's disease who failed to benefit from previous cholinesterase inhibitor treatment. International journal of clinical practice 20060101
The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease. Health technology assessment (Winchester, England) 20060101
Antipsychotic drug use among nursing home residents taking rivastigmine. Journal of the American Medical Directors Association 20060101
Economic evaluation of rivastigmine in patients with Parkinson's disease dementia. PharmacoEconomics 20060101
Transdermal rivastigmine treatment does not worsen impaired performance of complex motions in patients with Alzheimer's disease. Pharmacopsychiatry 20060101
QEEG monitoring of Alzheimer's disease treatment: a preliminary report of three case studies. Clinical EEG and neuroscience 20060101
A pilot study evaluating the efficacy and safety of rivastigmine in patients with mixed dementia. Drugs & aging 20060101
Current and emerging pharmacological treatment options for dementia. Behavioural neurology 20060101
Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. Alzheimer disease and associated disorders 20060101
Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease. Drugs & aging 20060101
Rivastigmine: in Parkinson's disease dementia. CNS drugs 20060101
[Pharmacotherapy for Alzheimer's disease]. Tijdschrift voor psychiatrie 20060101
Cholinesterase inhibitors in the clinical management of Alzheimer's disease: importance of early and persistent treatment. The Journal of international medical research 20060101
Changes in metabolite ratios after treatment with rivastigmine in Alzheimer's disease: a nonrandomised controlled trial with magnetic resonance spectroscopy. CNS drugs 20060101
A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20060101
Determination of therapeutics with growth-hormone secretagogue activity in human urine for doping control purposes. Rapid communications in mass spectrometry : RCM 20060101
Initiation of acetylcholinesterase inhibitors and complications of chronic airways disorders in elderly patients. Drug safety 20060101
Realistic expectations for treatment success in Alzheimer's disease. The journal of nutrition, health & aging 20060101
[Pharmacological approaches to the therapy of Alzheimer's disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20060101
Alzheimer disease and its management: a review. American journal of therapeutics 20060101
Relationship between the efficacy of rivastigmine and apolipoprotein E (epsilon4) in patients with mild to moderately severe Alzheimer disease. Alzheimer disease and associated disorders 20060101
First treatment for dementia of Parkinson's disease. FDA consumer 20060101
Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. The Journal of pharmacology and experimental therapeutics 20051201
Discontinuation of rivastigmine in routine clinical practice. International journal of geriatric psychiatry 20051201
Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study. Clinical rehabilitation 20051201
Dementia. Clinical evidence 20051201
Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology 20051122
Behavioral and neuropsychiatric outcomes in Alzheimer's disease. CNS spectrums 20051101
Effects of switching from an AChE inhibitor to a dual AChE-BuChE inhibitor in patients with Alzheimer's disease. Current medical research and opinion 20051101
Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles. Brain research 20051026
The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats. British journal of pharmacology 20051001
Effect of rivastigmine in the treatment of behavioral disturbances associated with dementia: review of neuropsychiatric impairment in Alzheimer's disease. Current medical research and opinion 20051001
Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects. Psychopharmacology 20050901
Rivastigmine for Alzheimer's disease. Expert review of neurotherapeutics 20050901
UK government guidance on Alzheimer's drugs postponed. Drug discovery today 20050901
Efficacy of rivastigmine on activities of daily living in Sri Lankan patients with Alzheimer disease and on improving caregiver burden: a prospective study. The Ceylon medical journal 20050901
Effects of rivastigmine treatment on the neuropsychiatric and behavioral disturbances of nursing home residents with moderate to severe probable Alzheimer's disease: a 26-week, multicenter, open-label study. The American journal of geriatric pharmacotherapy 20050901
Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials. BMJ (Clinical research ed.) 20050806
One-year treatment of Alzheimer's disease with acetylcholinesterase inhibitors: improvement on ADAS-cog and TMT A, no change or worsening on other tests. Human psychopharmacology 20050801
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Maintaining functional and behavioral abilities in Alzheimer disease. Alzheimer disease and associated disorders 20010801
Rivastigmine in subcortical vascular dementia: a comparison trial on efficacy and tolerability for 12 months follow-up. European journal of neurology 20010701
Use of cholinesterase inhibitors for treatment of Alzheimer disease. Cleveland Clinic journal of medicine 20010701
Featured CME topic: dementia. Medication update. Southern medical journal 20010701
Long-Term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial. International psychogeriatrics 20010601
Rivastagmine-induced agitation following transient recollection of autobiographical memory. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20010601
Review of rivastigmine and its clinical applications in Alzheimer's disease and related disorders. Expert opinion on pharmacotherapy 20010401
Response of patients with Alzheimer disease to rivastigmine treatment is predicted by the rate of disease progression. Archives of neurology 20010301
Spontaneous rupture of oesophagus (Boerhaave's syndrome) related to rivastigmine. Age and ageing 20010301
[Evaluation of the therapeutic effects in individual patients with Alzheimer disease]. Nederlands tijdschrift voor geneeskunde 20010224
Successful treatment of nonanticholinergic delirium with a cholinesterase inhibitor. Journal of clinical psychopharmacology 20010201
Brief review: rivastigmine, a second cholinesterase inhibitor. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20010201
Cholinesterase inhibitors for Alzheimer's disease. Drugs 20010101
Clinical and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review. Health technology assessment (Winchester, England) 20010101
Donepezil, rivastigmine, and vitamin E in Alzheimer disease: a combined P300 event-related potentials/neuropsychologic evaluation over 6 months. Clinical neuropharmacology 20010101
Rivastigmine. A pharmacoeconomic review of its use in Alzheimer's disease. PharmacoEconomics 20010101
Short-term rivastigmine treatment reduces EEG slow-wave power in Alzheimer patients. Neuropsychobiology 20010101
Pharmacokinetic profiles of current therapies for Alzheimer's disease: implications for switching to galantamine. Clinical therapeutics 20010101
[Current strategies of pathogenetic therapy of Alzheimer's disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101
Rivastigmine in the treatment of Alzheimer's disease. European neurology 20010101
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials. Neurologia i neurochirurgia polska 20010101
Drugs used for cognitive symptoms of Alzheimer's disease. Perspectives in psychiatric care 20010101
Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists. Japanese journal of pharmacology 20001001
Relation between cholinesterase inhibitor and Pisa syndrome. Lancet (London, England) 20000624
Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. BMJ (Clinical research ed.) 19990306
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