1,9-Pyrazoloanthrone
| Title | Journal |
|---|---|
| Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways. | Toxicology and applied pharmacology 20180915 |
| Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells. | Toxicology letters 20180701 |
| ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells. | Toxicology letters 20180615 |
| Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs. | Toxicology letters 20180515 |
| Exposure to DBP and High Iodine Aggravates Autoimmune Thyroid Disease Through Increasing the Levels of IL-17 and Thyroid-Binding Globulin in Wistar Rats. | Toxicological sciences : an official journal of the Society of Toxicology 20180501 |
| Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells. | Odontology 20180401 |
| Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats. | Toxicology letters 20180315 |
| t-BuOOH induces ferroptosis in human and murine cell lines. | Archives of toxicology 20180201 |
| Polyhexamethylene guanidine phosphate induces IL-6 and TNF-α expression through JNK-dependent pathway in human lung epithelial cells. | The Journal of toxicological sciences 20180101 |
| Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. | Toxicology 20171201 |
| β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. | Environmental toxicology 20171101 |
| Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells. | Chemico-biological interactions 20171101 |
| Polysaccharide purified from Ganoderma atrum induced activation and maturation of murine myeloid-derived dendritic cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001 |
| Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells. | Chemosphere 20171001 |
| Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis. | Toxicology 20170901 |
| Nimbolide induces apoptosis in human nasopharyngeal cancer cells. | Environmental toxicology 20170801 |
| Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20170801 |
| Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801 |
| Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA. | Chemico-biological interactions 20170801 |
| Sinigrin attenuates the progression of atherosclerosis in ApoE(-/-) mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression. | Chemico-biological interactions 20170625 |
| Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production. | Journal of biochemical and molecular toxicology 20170601 |
| The flame retardant 2,2',4,4'-Tetrabromodiphenyl ether enhances the expression of corticotropin-releasing hormone in the placental cell model JEG-3. | Chemosphere 20170501 |
| Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer. | Environmental toxicology 20170401 |
| Dysregulation of MAP Kinase Signaling Pathways Including p38MAPK, SAPK/JNK, and ERK1/2 in Cultured Rat Cerebellar Astrocytes Exposed to Diphenylarsinic Acid. | Toxicological sciences : an official journal of the Society of Toxicology 20170401 |
| Vibrio cholerae Cholix Toxin-Induced HepG2 Cell Death is Enhanced by Tumor Necrosis Factor-Alpha Through ROS and Intracellular Signal-Regulated Kinases. | Toxicological sciences : an official journal of the Society of Toxicology 20170401 |
| Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38. | Environmental toxicology 20170201 |
| mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells. | Environmental toxicology 20170101 |
| Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20170101 |
| Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells. | Chemico-biological interactions 20161225 |
| Aflatoxin B1 disrupts transient receptor potential channel activity and increases COX-2 expression in JEG-3 placental cells. | Chemico-biological interactions 20161225 |
| Atg5-dependent autophagy plays a protective role against methylmercury-induced cytotoxicity. | Toxicology letters 20161116 |
| Neogambogic acid prevents silica-induced fibrosis via inhibition of high-mobility group box 1 and MCP-1-induced protein 1. | Toxicology and applied pharmacology 20161015 |
| Air pollution-related metals induce differential cytokine responses in bronchial epithelial cells. | Toxicology in vitro : an international journal published in association with BIBRA 20161001 |
| Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | Oncotarget 20160920 |
| 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. | Archives of toxicology 20160901 |
| Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells. | Journal of applied toxicology : JAT 20160901 |
| The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160901 |
| Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion. | Toxicology 20160729 |
| Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway. | Toxicology and applied pharmacology 20160715 |
| Benzo(a)pyrene inhibits migration and invasion of extravillous trophoblast HTR-8/SVneo cells via activation of the ERK and JNK pathway. | Journal of applied toxicology : JAT 20160701 |
| Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling. | Toxicology 20160701 |
| MCPIP1 Regulates Alveolar Macrophage Apoptosis and Pulmonary Fibroblast Activation After in vitro Exposure to Silica. | Toxicological sciences : an official journal of the Society of Toxicology 20160501 |
| Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression. | Cell death and differentiation 20160401 |
| Hydroquinone stimulates cell invasion through activator protein-1-dependent induction of MMP-9 in HepG2 human hepatoma cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160301 |
| Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase. | Toxicology 20160217 |
| Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines. | Toxicological sciences : an official journal of the Society of Toxicology 20160201 |
| Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis. | Chemical research in toxicology 20160119 |
| The Role of MAPK Pathways in Airborne Fine Particulate Matter-Induced Upregulation of Endothelin Receptors in Rat Basilar Arteries. | Toxicological sciences : an official journal of the Society of Toxicology 20160101 |
| The role of HO-1 in protection against lead-induced neurotoxicity. | Neurotoxicology 20160101 |
| DJ-1 mutation decreases astroglial release of inflammatory mediators. | Neurotoxicology 20160101 |
| Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. | PloS one 20160101 |
| Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. | Toxicology 20151202 |
| Involvement of mitogen-activated protein kinase and NF-κB signaling pathways in perfluorooctane sulfonic acid-induced inflammatory reaction in BV2 microglial cells. | Journal of applied toxicology : JAT 20151201 |
| Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. | Toxicology and applied pharmacology 20151201 |
| CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings. | Toxicology and applied pharmacology 20151201 |
| Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways. | Archives of toxicology 20151101 |
| Low-dose Bisphenol A Activates Cyp11a1 Gene Expression and Corticosterone Secretion in Adrenal Gland via the JNK Signaling Pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20151101 |
| Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. | Oncotarget 20151020 |
| Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. | Toxicology and applied pharmacology 20151015 |
| Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells. | Toxicological sciences : an official journal of the Society of Toxicology 20151001 |
| Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene. | Biochimica et biophysica acta 20151001 |
| Quercetin protects mouse liver against CCl₄-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway. | International immunopharmacology 20150901 |
| Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines. | Chemical research in toxicology 20150817 |
| Formoterol synergy with des-ciclesonide inhibits IL-4 expression in IgE/antigen-induced mast cells by inhibiting JNK activation. | European journal of pharmacology 20150815 |
| Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells. | Journal of cellular biochemistry 20150801 |
| The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. | Free radical biology & medicine 20150801 |
| Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation. | Environmental toxicology 20150708 |
| FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. | Toxicology letters 20150702 |
| Reactive oxygen species-dependent JNK downregulated olaquindox-induced autophagy in HepG2 cells. | Journal of applied toxicology : JAT 20150701 |
| Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells. | Chemico-biological interactions 20150625 |
| Quercetin promotes the osteogenic differentiation of rat mesenchymal stem cells via mitogen-activated protein kinase signaling. | Experimental and therapeutic medicine 20150601 |
| Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. | Chemical research in toxicology 20150518 |
| The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. | Molecular medicine reports 20150501 |
| MAPK and NF-κB pathways are involved in bisphenol A-induced TNF-α and IL-6 production in BV2 microglial cells. | Inflammation 20150401 |
| Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts. | Toxicology in vitro : an international journal published in association with BIBRA 20150301 |
| Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation. | Acta pharmacologica Sinica 20150301 |
| Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function. | Toxicology and applied pharmacology 20150215 |
| JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. | Toxicology 20150203 |
| Activation of MAPK pathways and downstream transcription factors in 2-aminobiphenyl-induced apoptosis. | Environmental toxicology 20150201 |
| JNK implication in adipocyte-like cell death induced by chemotherapeutic drug cisplatin. | The Journal of toxicological sciences 20150201 |
| Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas. | Oncotarget 20150201 |
| Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway. | Chemical research in toxicology 20150120 |
| Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction. | Chemico-biological interactions 20150105 |
| The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20150101 |
| Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase. | Prostaglandins & other lipid mediators 20150101 |
| Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes. | BMC complementary and alternative medicine 20150101 |
| The Green Tea Component (-)-Epigallocatechin-3-Gallate Sensitizes Primary Endothelial Cells to Arsenite-Induced Apoptosis by Decreasing c-Jun N-Terminal Kinase-Mediated Catalase Activity. | PloS one 20150101 |
| Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. | EMBO molecular medicine 20141201 |
| Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2. | International journal of oncology 20141201 |
| Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. | Molecular carcinogenesis 20141101 |
| The role of autophagy in usnic acid-induced toxicity in hepatic cells. | Toxicological sciences : an official journal of the Society of Toxicology 20141101 |
| Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts. | International journal of molecular medicine 20141101 |
| Induction of GADD45α protects M17 neuroblastoma cells against MPP*. | IUBMB life 20141101 |
| Dibutyltin promotes oxidative stress and increases inflammatory mediators in BV-2 microglia cells. | Toxicology letters 20141015 |
| Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells. | Chemico-biological interactions 20141005 |
| Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. | Molecular neurobiology 20141001 |
| Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts. | International journal of molecular sciences 20141001 |
| Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20140901 |
| Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway. | Toxicology and applied pharmacology 20140901 |
| BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells. | Toxicological sciences : an official journal of the Society of Toxicology 20140801 |
| Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping. | Molecular pharmacology 20140801 |
| Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | Toxicology and applied pharmacology 20140701 |
| Preferential expression of PAPPA in human preadipocytes from omental fat. | The Journal of endocrinology 20140701 |
| Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways. | Oncology reports 20140701 |
| Molecular mechanisms of cadmium-induced fibroblast growth factor 23 upregulation in osteoblast-like cells. | Toxicological sciences : an official journal of the Society of Toxicology 20140601 |
| Withaferin A is an inhibitor of endothelial protein C receptor shedding in vitro and in vivo. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140601 |
| Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. | International journal of molecular medicine 20140601 |
| Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation. | Cancer letters 20140501 |
| Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase. | The Journal of pharmacology and experimental therapeutics 20140501 |
| Cadmium induces PC12 cells apoptosis via an extracellular signal-regulated kinase and c-Jun N-terminal kinase-mediated mitochondrial apoptotic pathway. | Biological trace element research 20140501 |
| Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. | Cancer science 20140501 |
| Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. | Chemico-biological interactions 20140325 |
| Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. | Toxicology and applied pharmacology 20140301 |
| Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach. | Toxicology 20140227 |
| Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. | Free radical biology & medicine 20140201 |
| The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease. | Free radical biology & medicine 20140201 |
| Humic acid in drinking well water induces inflammation through reactive oxygen species generation and activation of nuclear factor-κB/activator protein-1 signaling pathways: a possible role in atherosclerosis. | Toxicology and applied pharmacology 20140115 |
| Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway. | Toxicology and applied pharmacology 20140115 |
| Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling. | Archives of biochemistry and biophysics 20140115 |
| Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways. | Toxicology letters 20140103 |
| Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs. | Drug metabolism and disposition: the biological fate of chemicals 20140101 |
| Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. | Journal of neurochemistry 20140101 |
| CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes. | Cell death & disease 20140101 |
| Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | Nature communications 20140101 |
| Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC. | Biological & pharmaceutical bulletin 20140101 |
| FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101 |
| Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. | Immunobiology 20131201 |
| Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. | Biochimica et biophysica acta 20131201 |
| Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway. | Toxicology and applied pharmacology 20131115 |
| Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells. | Toxicology and applied pharmacology 20131101 |
| ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione. | The international journal of biochemistry & cell biology 20131101 |
| NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells. | Toxicology and applied pharmacology 20131015 |
| The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. | Toxicology and applied pharmacology 20131015 |
| Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells. | Toxicology letters 20131009 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces microglial nitric oxide production and subsequent rat primary cortical neuron apoptosis through p38/JNK MAPK pathway. | Toxicology 20131004 |
| Immunostimulatory activity of polysaccharides from Cheonggukjang. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130901 |
| Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801 |
| Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells. | Bioorganic & medicinal chemistry letters 20130801 |
| MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. | Toxicology letters 20130731 |
| Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways. | Archives of toxicology 20130701 |
| Galangin attenuates mast cell-mediated allergic inflammation. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130701 |
| Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells. | Toxicology letters 20130620 |
| Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway. | Toxicology letters 20130607 |
| Sodium fluoride induces apoptosis in odontoblasts via a JNK-dependent mechanism. | Toxicology 20130607 |
| Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic. | Archives of toxicology 20130601 |
| Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid. | Toxicology and applied pharmacology 20130515 |
| Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway. | The Journal of biological chemistry 20130510 |
| A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation. | Archives of toxicology 20130501 |
| Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity. | Glia 20130501 |
| JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis. | Toxicology letters 20130426 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells. | Toxicology 20130405 |
| Retinoic acid influences the embryoid body formation in mouse embryonic stem cells by induction of caspase and p38 MAPK/JNK-mediated apoptosis. | Environmental toxicology 20130401 |
| Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. | Experimental cell research 20130401 |
| Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction. | Toxicology in vitro : an international journal published in association with BIBRA 20130401 |
| β-Ionone attenuates LPS-induced pro-inflammatory mediators such as NO, PGE2 and TNF-α in BV2 microglial cells via suppression of the NF-κB and MAPK pathway. | Toxicology in vitro : an international journal published in association with BIBRA 20130301 |
| Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. | Toxicology in vitro : an international journal published in association with BIBRA 20130301 |
| TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells. | Biochemical pharmacology 20130115 |
| Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. | Toxicology 20130107 |
| Exposure to the JNK inhibitor SP600125 (anthrapyrazolone) during early zebrafish development results in morphological defects. | Journal of applied toxicology : JAT 20130101 |
| Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression. | Journal of applied toxicology : JAT 20130101 |
| JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. | Cell cycle (Georgetown, Tex.) 20130101 |
| The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells. | PloS one 20130101 |
| A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. | PloS one 20130101 |
| Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. | PloS one 20130101 |
| The antimetastatic effects of resveratrol on hepatocellular carcinoma through the downregulation of a metastasis-associated protease by SP-1 modulation. | PloS one 20130101 |
| Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis. | Oxidative medicine and cellular longevity 20130101 |
| GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. | PloS one 20130101 |
| JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells. | Mediators of inflammation 20130101 |
| Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells. | PloS one 20130101 |
| Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity. | Open journal of apoptosis 20130101 |
| High glucose-induced increased expression of endothelin-1 in human endothelial cells is mediated by activated CCAAT/enhancer-binding proteins. | PloS one 20130101 |
| Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. | Clinical cancer research : an official journal of the American Association for Cancer Research 20121215 |
| JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. | Toxicology 20121208 |
| Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. | Diabetes 20121201 |
| Apoptosis of K562 leukemia cells by Abnobaviscum F®, a European mistletoe extract. | Oncology reports 20121201 |
| Quercetin up-regulates LDL receptor expression in HepG2 cells. | Phytotherapy research : PTR 20121101 |
| Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts. | Journal of cellular biochemistry 20121101 |
| Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway. | Cellular signalling 20121101 |
| Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121101 |
| Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. | Journal of lipid research 20121101 |
| Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes. | Toxicology 20121028 |
| Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc. | European journal of nutrition 20121001 |
| Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death. | Journal of cellular biochemistry 20121001 |
| JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. | Toxicological sciences : an official journal of the Society of Toxicology 20121001 |
| Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway. | Biochimica et biophysica acta 20121001 |
| Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymyxin B. | Cytokine 20121001 |
| Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells. | International journal of molecular medicine 20121001 |
| Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. | European journal of pharmacology 20120905 |
| Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures. | Toxicology letters 20120903 |
| Preliminary evidence for the dedifferentiation of RAW 264.7 cells into mesenchymal progenitor-like cells by a purine analog. | Tissue engineering. Part A 20120901 |
| Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901 |
| Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901 |
| The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. | Molecular cancer research : MCR 20120901 |
| Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1. | Chemico-biological interactions 20120830 |
| PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120801 |
| Inhibitory effect of Styrax Japonica Siebold et al. Zuccarini glycoprotein (38 kDa) on interleukin-1β and induction proteins in chromium(VI)-treated BNL CL.2 cells. | Molecular and cellular biochemistry 20120801 |
| Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation. | Molecular and cellular biochemistry 20120801 |
| Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-κB. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801 |
| Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations. | Journal of neurochemistry 20120801 |
| Inhibition of c-Jun N-terminal kinase prevents blood-brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage. | Acta neurochirurgica 20120801 |
| cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway. | Biochemical and biophysical research communications 20120713 |
| Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines. | Toxicology letters 20120707 |
| Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3. | British journal of pharmacology 20120701 |
| Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2. | Molecular and cellular biochemistry 20120701 |
| The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes. | Archives of pharmacal research 20120701 |
| Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia. | Investigative ophthalmology & visual science 20120628 |
| Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120613 |
| Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. | Journal of cellular biochemistry 20120601 |
| Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation. | Molecular & cellular proteomics : MCP 20120601 |
| Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601 |
| Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways. | Archives of toxicology 20120601 |
| Tumor necrosis factor-α and interleukin-1β expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7. | Molecular oral microbiology 20120601 |
| [The protective effects of inhibition of c-Jun N-terminal kinase signal pathway on the intestinal barrier in rats with endotoxemia]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120601 |
| Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. | The Journal of biological chemistry 20120518 |
| Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2. | Journal of cellular physiology 20120501 |
| Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells. | Microvascular research 20120501 |
| Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice. | Pharmacology, biochemistry, and behavior 20120501 |
| Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis. | Brain research 20120411 |
| Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways. | Journal of applied toxicology : JAT 20120401 |
| Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor. | Inflammation 20120401 |
| IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells. | Inflammation 20120401 |
| Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. | Phytotherapy research : PTR 20120401 |
| Effects of c-Jun N-terminal kinase signaling pathway on severe acute pancreatitis-associated lung injury. | Pancreas 20120401 |
| High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. | The international journal of biochemistry & cell biology 20120401 |
| Daunorubicin induces cell death via activation of apoptotic signalling pathway and inactivation of survival pathway in muscle-derived stem cells. | Cell biology and toxicology 20120401 |
| Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia. | Biochimica et biophysica acta 20120401 |
| Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line. | Chemical research in toxicology 20120319 |
| Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. | European journal of pharmacology 20120315 |
| Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model. | Biochemical and biophysical research communications 20120302 |
| Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway. | Molecular and cellular biochemistry 20120301 |
| Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells. | Toxicological sciences : an official journal of the Society of Toxicology 20120301 |
| Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. | Carcinogenesis 20120301 |
| Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells. | Toxicology and applied pharmacology 20120301 |
| P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. | Free radical research 20120301 |
| Fructose-1,6-bisphosphate attenuates induction of nitric oxide synthase in microglia stimulated with lipopolysaccharide. | Life sciences 20120227 |
| Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells. | Toxicology letters 20120205 |
| Effect of donor JNK signal transduction inhibition on transplant outcome in brain dead rat model. | Inflammation 20120201 |
| Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies. | The Journal of nutritional biochemistry 20120201 |
| Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. | Inflammation 20120201 |
| Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases. | American journal of physiology. Cell physiology 20120201 |
| Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage. | Toxicology in vitro : an international journal published in association with BIBRA 20120201 |
| Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. | International journal of oncology 20120201 |
| Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies. | Biochemical Society transactions 20120201 |
| SNP-induced apoptosis may be mediated with caspase inhibitor by JNK signaling pathways in rabbit articular chondrocytes. | The Journal of toxicological sciences 20120201 |
| [Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20120201 |
| Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. | Cancer letters 20120128 |
| Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells. | American journal of physiology. Lung cellular and molecular physiology 20120115 |
| A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. | Toxicology and applied pharmacology 20120115 |
| c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production. | Biochemical and biophysical research communications 20120106 |
| Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120101 |
| Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells. | Experimental cell research 20120101 |
| The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors. | Toxicological sciences : an official journal of the Society of Toxicology 20120101 |
| Function of MAPK and downstream transcription factors in monomer-induced apoptosis. | Biomaterials 20120101 |
| The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation. | Journal of Alzheimer's disease : JAD 20120101 |
| Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells. | Endocrinology 20120101 |
| SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral. | Antiviral research 20120101 |
| GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. | PloS one 20120101 |
| miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. | PloS one 20120101 |
| Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway. | Neuro-degenerative diseases 20120101 |
| Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. | PloS one 20120101 |
| Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells. | BMC research notes 20120101 |
| High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5. | Molecular vision 20120101 |
| MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells. | PloS one 20120101 |
| Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNK. | International journal of molecular sciences 20120101 |
| Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition. | PloS one 20120101 |
| Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism. | Journal of biomedicine & biotechnology 20120101 |
| Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells. | The Journal of toxicological sciences 20120101 |
| Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. | PloS one 20120101 |
| [Effects of several inhibitors of intracellular signaling on production of cytokines and signal proteins in RAW 264.7 cells cultivated with low dose ammonium]. | Biofizika 20120101 |
| Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes. | PloS one 20120101 |
| Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| The apoptotic volume decrease is an upstream event of MAP kinase activation during Staurosporine-induced apoptosis in HeLa cells. | International journal of molecular sciences 20120101 |
| Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition. | PloS one 20120101 |
| Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells. | Molecular vision 20120101 |
| Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | PloS one 20120101 |
| Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells. | Blood cells, molecules & diseases 20111215 |
| Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. | Biochemical and biophysical research communications 20111202 |
| Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. | Journal of hepatology 20111201 |
| Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. | Biochimica et biophysica acta 20111201 |
| MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | Biochimica et biophysica acta 20111201 |
| CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death. | Journal of neurochemistry 20111201 |
| MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes. | Placenta 20111201 |
| JNK inhibitors increase osteogenesis in Nf1-deficient cells. | Bone 20111201 |
| Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization. | Environmental science & technology 20111201 |
| Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide. | Journal of endodontics 20111201 |
| Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades. | Expert opinion on therapeutic targets 20111201 |
| Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs. | Journal of medicinal chemistry 20111124 |
| Ellipticine induces apoptosis in human endometrial cancer cells: the potential involvement of reactive oxygen species and mitogen-activated protein kinases. | Toxicology 20111118 |
| Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death. | Toxicology 20111118 |
| Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells. | Chemico-biological interactions 20111115 |
| Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation. | Journal of applied physiology (Bethesda, Md. : 1985) 20111101 |
| c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. | Neuroscience research 20111101 |
| Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation. | Journal of cellular physiology 20111101 |
| Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants. | Bioorganic & medicinal chemistry 20111101 |
| The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase. | The Journal of infectious diseases 20111101 |
| FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway. | Investigative ophthalmology & visual science 20111101 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction. | The Journal of biological chemistry 20111021 |
| Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. | Chemical research in toxicology 20111017 |
| Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite. | Toxicology letters 20111010 |
| Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species. | Toxicology in vitro : an international journal published in association with BIBRA 20111001 |
| Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. | Glia 20111001 |
| Parathyroid hormone and the regulation of cell cycle in colon adenocarcinoma cells. | Biochimica et biophysica acta 20111001 |
| JNK inhibition by SP600125 attenuates trans-10, cis-12 conjugated linoleic acid-mediated regulation of inflammatory and lipogenic gene expression. | Lipids 20111001 |
| Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. | Anticancer research 20111001 |
| Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. | Journal of medicinal chemistry 20110922 |
| Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells. | Biochemical and biophysical research communications 20110916 |
| Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes. | British journal of pharmacology 20110901 |
| Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. | Journal of molecular medicine (Berlin, Germany) 20110901 |
| tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK. | Neurological research 20110901 |
| Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation. | Molecular immunology 20110901 |
| Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. | The Journal of biological chemistry 20110819 |
| Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2. | Antioxidants & redox signaling 20110815 |
| Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells. | Chemico-biological interactions 20110815 |
| Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. | Cancer biology & therapy 20110815 |
| MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-α secretion following OK-432 in vitro stimulation of purified human monocytes. | Scandinavian journal of immunology 20110801 |
| Increased JNK1 activity contributes to the upregulation of ApoD in the apocrine secretory gland cells from axillary osmidrosis. | Molecular and cellular biochemistry 20110801 |
| Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro. | Journal of biochemistry 20110801 |
| A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells. | Cancer biology & therapy 20110801 |
| P66Shc mediated ferritin degradation--a novel mechanism of ROS formation. | Free radical biology & medicine 20110801 |
| Effects of downregulation of aquaporin1 by peptidoglycan and lipopolysaccharide via MAPK pathways in MeT-5A cells. | Lung 20110801 |
| The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. | The Journal of biological chemistry 20110729 |
| Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride--a mechanism connected with activating JNK phosphorylation. | Toxicology letters 20110728 |
| SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. | Stem cells and development 20110701 |
| 5-aminolevulinic acid induce apoptosis via NF-κB/JNK pathway in human oral cancer Ca9-22 cells. | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20110701 |
| Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes. | Molecular and cellular biochemistry 20110701 |
| ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers. | American journal of physiology. Gastrointestinal and liver physiology 20110701 |
| Protective effects of SP600125 on renal ischemia-reperfusion injury in rats. | The Journal of surgical research 20110701 |
| CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors. | Cytokine 20110701 |
| Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. | Biochimica et biophysica acta 20110701 |
| Identification of new inhibitors of protein kinase R guided by statistical modeling. | Bioorganic & medicinal chemistry letters 20110701 |
| CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes. | Biochemical and biophysical research communications 20110617 |
| Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation. | The Biochemical journal 20110615 |
| Toll-like receptor 2-mediated sequential activation of MyD88 and MAPKs contributes to lipopolysaccharide-induced sp-a gene expression in human alveolar epithelial cells. | Immunobiology 20110601 |
| Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury. | Shock (Augusta, Ga.) 20110601 |
| Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin. | Experimental neurology 20110601 |
| The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)]. | Biochemical pharmacology 20110601 |
| Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation. | Biochimica et biophysica acta 20110601 |
| Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | Toxicology and applied pharmacology 20110601 |
| Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells. | Journal of dermatological science 20110601 |
| Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages. | Biochimica et biophysica acta 20110601 |
| Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression. | Toxicology letters 20110530 |
| Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of rapamycin in LS174T colon cancer cells. | The Journal of surgical research 20110515 |
| Virtual screening and further development of novel ALK inhibitors. | Bioorganic & medicinal chemistry 20110515 |
| Activation of the JNK pathway by nanosecond pulsed electric fields. | Biochemical and biophysical research communications 20110513 |
| Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells. | Journal of agricultural and food chemistry 20110511 |
| Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. | Biochimica et biophysica acta 20110501 |
| Regulation of JNK activity in the apoptotic response of intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20110501 |
| Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles. | Journal of immunology (Baltimore, Md. : 1950) 20110501 |
| c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. | Yonsei medical journal 20110501 |
| Interference of the apoptotic signaling pathway in RGC stress response by SP600125 in moderate ocular hypertensive rats. | The Chinese journal of physiology 20110430 |
| Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. | Science (New York, N.Y.) 20110415 |
| 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected]. | European journal of pharmacology 20110410 |
| p,p'-Dichlorodiphenoxydichloroethylene induced apoptosis of Sertoli cells through oxidative stress-mediated p38 MAPK and mitochondrial pathway. | Toxicology letters 20110410 |
| Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells. | Digestive diseases and sciences 20110401 |
| Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase. | Nephron. Physiology 20110401 |
| Lithospermic acid B protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1. | Toxicology and applied pharmacology 20110401 |
| Insulin-induced oxidative stress up-regulates heme oxygenase-1 via diverse signaling cascades in the C2 skeletal myoblast cell line. | Endocrinology 20110401 |
| Role of c-Jun N-terminal kinase activation in blastema formation during planarian regeneration. | Development, growth & differentiation 20110401 |
| Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells. | Biochemical and biophysical research communications 20110318 |
| Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells. | Toxicology and applied pharmacology 20110315 |
| Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds. | Bioorganic & medicinal chemistry 20110315 |
| Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. | European journal of pharmacology 20110311 |
| Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway. | Archives of toxicology 20110301 |
| Preantral follicle growth is regulated by c-Jun-N-terminal kinase (JNK) pathway. | Reproductive sciences (Thousand Oaks, Calif.) 20110301 |
| Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1-42) associated with decrease of apoptotic factors. | Behavioural brain research 20110301 |
| Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618. | Carcinogenesis 20110301 |
| Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway. | Archives of biochemistry and biophysics 20110215 |
| JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201 |
| Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. | Apoptosis : an international journal on programmed cell death 20110201 |
| Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. | Oncology reports 20110201 |
| Targeting transcription through inhibition of TBP. | Oncotarget 20110201 |
| α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. | British journal of cancer 20110104 |
| Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene. | Circulation 20110104 |
| Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment. | Journal of cellular physiology 20110101 |
| Gefitinib-induced epidermal growth factor receptor-independent keratinocyte apoptosis is mediated by the JNK activation pathway. | The British journal of dermatology 20110101 |
| Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells. | Toxicology and applied pharmacology 20110101 |
| Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons. | British journal of pharmacology 20110101 |
| Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut. | Molecular and cellular biochemistry 20110101 |
| Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. | Journal of gastroenterology and hepatology 20110101 |
| The sequential combination of a JNK inhibitor and simvastatin protects porcine islets from peritransplant apoptosis and inflammation. | Cell transplantation 20110101 |
| SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway. | Cell structure and function 20110101 |
| [Effect of JNK pathway in apoptosis of PC12 cell by MPP+]. | Wei sheng yan jiu = Journal of hygiene research 20110101 |
| Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways. | Archives of pharmacal research 20110101 |
| Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells. | BMC cancer 20110101 |
| Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension. | Molecular vision 20110101 |
| Tumor necrosis factor-α enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells. | Journal of biomedical science 20110101 |
| Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. | Mediators of inflammation 20110101 |
| CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. | Arthritis research & therapy 20110101 |
| Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma. | PloS one 20110101 |
| Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice. | Molecular medicine (Cambridge, Mass.) 20110101 |
| Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism. | Cancer cell international 20110101 |
| Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells. | Journal of neuroinflammation 20110101 |
| Resveratrol inhibits Cdk5 activity through regulation of p35 expression. | Molecular pain 20110101 |
| Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response. | Journal of biomedical science 20110101 |
| Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK. | PloS one 20110101 |
| Stretch-inducible expression of connective tissue growth factor (CTGF) in human osteoblasts-like cells is mediated by PI3K-JNK pathway. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| Coordinated regulation of ATF2 by miR-26b in γ-irradiated lung cancer cells. | PloS one 20110101 |
| c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells. | Journal of translational medicine 20110101 |
| Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. | PloS one 20110101 |
| Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways. | Toxicology letters 20101215 |
| Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. | Free radical biology & medicine 20101215 |
| Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway. | Journal of immunology (Baltimore, Md. : 1950) 20101215 |
| Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. | Cancer research 20101215 |
| p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation. | Cell death and differentiation 20101201 |
| JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. | Apoptosis : an international journal on programmed cell death 20101201 |
| Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK. | Toxicology and applied pharmacology 20101115 |
| Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells. | Cancer research 20101115 |
| Resveratrol enhances NK cell cytotoxicity: possible role for aryl hydrocarbon receptor. | Journal of cellular physiology 20101101 |
| DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells. | Cancer letters 20101101 |
| Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor. | Planta medica 20101101 |
| The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. | Journal of pineal research 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats. | Brain research 20101021 |
| The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. | Toxicology letters 20101020 |
| Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes. | Toxicology 20101009 |
| 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. | Toxicology letters 20101005 |
| SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats. | Pharmacology, biochemistry, and behavior 20101001 |
| MCP-1 production in temporomandibular joint inflammation. | Journal of dental research 20101001 |
| [Simvastatin suppress lipopolysaccharides induced upregulation of lipoprotein associated phospholipase A(2) expression in macrophages via inactivation of p38MAPK pathway]. | Zhonghua xin xue guan bing za zhi 20101001 |
| The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. | FEBS letters 20100924 |
| Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100901 |
| Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery. | Toxicology letters 20100901 |
| Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase. | International immunopharmacology 20100901 |
| Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. | Molecular carcinogenesis 20100901 |
| Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100901 |
| Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen. | Die Pharmazie 20100901 |
| HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. | Journal of cellular and molecular medicine 20100801 |
| Pyrogallol-induced As4.1 juxtaglomerular cell death is attenuated by MAPK inhibitors via preventing GSH depletion. | Archives of toxicology 20100801 |
| Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis. | Free radical biology & medicine 20100801 |
| JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. | Cytokine 20100801 |
| Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK. | American journal of physiology. Regulatory, integrative and comparative physiology 20100801 |
| Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. | Journal of cellular biochemistry 20100801 |
| The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide. | Molecular carcinogenesis 20100801 |
| Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. | British journal of pharmacology 20100801 |
| N-acetylcysteine protects alveolar epithelial cells from hydrogen peroxide-induced apoptosis through scavenging reactive oxygen species and suppressing c-Jun N-terminal kinase. | Experimental lung research 20100801 |
| Control of TrkA-induced cell death by JNK activation and differential expression of TrkA upon DNA damage. | Molecules and cells 20100801 |
| 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. | World journal of gastroenterology 20100721 |
| Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4. | European heart journal 20100701 |
| Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats. | Pancreas 20100701 |
| Mycophenolic acid attenuates tumor necrosis factor-alpha-induced endothelin-1 production in human aortic endothelial cells. | Atherosclerosis 20100701 |
| Down-expression of PGC-1alpha partially mediated by JNK/c-Jun through binding to CRE site during apoptotic procedure in cerebellar granule neurons. | Journal of neuroscience research 20100701 |
| Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis. | Journal of neuroscience research 20100701 |
| Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. | Journal of cellular physiology 20100701 |
| Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. | Toxicological sciences : an official journal of the Society of Toxicology 20100701 |
| JNK inhibition arrests cotranslational degradation. | Biochimica et biophysica acta 20100701 |
| Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100701 |
| c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. | Toxicology and applied pharmacology 20100701 |
| PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia. | American journal of physiology. Heart and circulatory physiology 20100701 |
| Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways. | Endocrinology 20100701 |
| Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells. | Free radical research 20100701 |
| Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor. | Endocrinology 20100701 |
| Mechanisms of IL-12 synthesis by human dendritic cells treated with the chemical sensitizer NiSO4. | Journal of immunology (Baltimore, Md. : 1950) 20100701 |
| The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions. | Cell biochemistry and function 20100701 |
| p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. | The Journal of biological chemistry 20100625 |
| Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms. | Biochemical pharmacology 20100615 |
| Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. | Toxicology and applied pharmacology 20100615 |
| Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. | European journal of pharmacology 20100610 |
| Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. | Blood 20100610 |
| The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP. | Chemico-biological interactions 20100607 |
| Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells. | Molecular and cellular biochemistry 20100601 |
| Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs. | Toxicology in vitro : an international journal published in association with BIBRA 20100601 |
| Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38. | Cutaneous and ocular toxicology 20100601 |
| JNK pathway is required for TNCB-induced IL-18 expression in murine keratinocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20100601 |
| Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. | Cardiovascular toxicology 20100601 |
| The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics. | Journal of endodontics 20100601 |
| Inhibition of the JNK signal cascade conserves hearing against electrode insertion trauma-induced loss. | Cochlear implants international 20100601 |
| Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death. | Toxicology letters 20100519 |
| Mycophenolic acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells. | Chemico-biological interactions 20100514 |
| Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways. | Journal of cellular physiology 20100501 |
| Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. | Atherosclerosis 20100501 |
| Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway. | International journal of hematology 20100501 |
| Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100501 |
| SP600125, an inhibitor of c-Jun NH2-terminal kinase, blocks expression of angiotensin II-induced monocyte chemoattractant protein-1 in human mesangial cells. | World journal of pediatrics : WJP 20100501 |
| TNF-alpha reduces the Na+/K+ ATPase activity in LLC-PK1 cells by activating caspases and JNK and inhibiting NF-kappaB. | Cell biology international 20100427 |
| Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts. | Toxicology and applied pharmacology 20100415 |
| Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. | Toxicology and applied pharmacology 20100415 |
| Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line. | Regulatory peptides 20100409 |
| The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes. | Leukemia research 20100401 |
| Betacellulin protects from pancreatitis by activating stress-activated protein kinase. | Gastroenterology 20100401 |
| Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways. | Molecular pharmacology 20100401 |
| Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20100401 |
| Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells. | Critical care medicine 20100401 |
| Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR. | Molecular oncology 20100401 |
| Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. | The Journal of toxicological sciences 20100401 |
| Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. | Journal of periodontal research 20100401 |
| Proinflammatory effects of muramyldipeptide on human gingival fibroblasts. | Journal of periodontal research 20100401 |
| Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation. | Chemico-biological interactions 20100330 |
| Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 up-regulation in rat testicular Leydig cells. | Toxicology letters 20100315 |
| Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. | Neuroscience letters 20100303 |
| Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. | Biochemistry 20100302 |
| Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. | Cell death and differentiation 20100301 |
| Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation. | Neuroscience research 20100301 |
| Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway. | Hearing research 20100301 |
| Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3. | Endocrinology 20100301 |
| Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. | Free radical research 20100301 |
| Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. | Cancer letters 20100227 |
| Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. | Chemico-biological interactions 20100212 |
| Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. | The Journal of biological chemistry 20100205 |
| Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. | Toxicology in vitro : an international journal published in association with BIBRA 20100201 |
| Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. | Molecular carcinogenesis 20100201 |
| Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells. | Toxicology in vitro : an international journal published in association with BIBRA 20100201 |
| Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. | Cellular and molecular life sciences : CMLS 20100201 |
| Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic beta-cells. | Peptides 20100201 |
| Effects of UVA on TNF-alpha, IL-1beta, and IL-10 expression levels in human keratinocytes and intervention studies with an antioxidant and a JNK inhibitor. | Photodermatology, photoimmunology & photomedicine 20100201 |
| Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. | Cell death & disease 20100201 |
| Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts. | Experimental & molecular medicine 20100131 |
| Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species. | Oncogene 20100128 |
| Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells. | Journal of cellular physiology 20100101 |
| Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. | Gastroenterology 20100101 |
| Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101 |
| Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways. | Veterinary research 20100101 |
| JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20100101 |
| Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line. | Toxicological sciences : an official journal of the Society of Toxicology 20100101 |
| (-)-Epigallocatechin-3-gallate decreases thrombin/paclitaxel-induced endothelial tissue factor expression via the inhibition of c-Jun terminal NH2 kinase phosphorylation. | Biochemical and biophysical research communications 20100101 |
| Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity. | Frontiers in bioscience (Elite edition) 20100101 |
| Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors. | Molecular pain 20100101 |
| Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils. | Journal of inflammation (London, England) 20100101 |
| Induction of LRF-1/ATF3 by vasopressin in hepatocytes: role of MAP kinases. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Inhibition of c-Jun N-terminal kinase by SP600125: a cDNA microarray analysis. | Cancer genomics & proteomics 20100101 |
| Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene. | Biochimica et biophysica acta 20100101 |
| Resveratrol differentially modulates inflammatory responses of microglia and astrocytes. | Journal of neuroinflammation 20100101 |
| Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. | PloS one 20100101 |
| Doxorubicin induces apoptosis in H9c2 cardiomyocytes: role of overexpressed eukaryotic translation initiation factor 5A. | Biological & pharmaceutical bulletin 20100101 |
| Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL. | Molecular cancer 20100101 |
| Ligand-independent activation of the androgen receptor by insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells. | Molecules and cells 20091231 |
| NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance. | Neuroscience letters 20091225 |
| Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. | Biochemistry 20091222 |
| Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells. | Journal of neuro-oncology 20091201 |
| Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells. | Biochimica et biophysica acta 20091201 |
| Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent. | Biology of reproduction 20091201 |
| c-Jun NH2-terminal kinase is crucially involved in renal tubulo-interstitial inflammation. | The Journal of pharmacology and experimental therapeutics 20091201 |
| ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation. | Free radical biology & medicine 20091201 |
| Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. | American journal of physiology. Heart and circulatory physiology 20091201 |
| Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. | Endocrinology 20091201 |
| Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. | Endocrinology 20091201 |
| Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20091201 |
| Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts. | Journal of periodontal research 20091201 |
| Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway. | Neuroscience bulletin 20091201 |
| Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. | Molecular cancer therapeutics 20091201 |
| c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines. | European journal of oral sciences 20091201 |
| Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis. | The Journal of biological chemistry 20091127 |
| Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20091101 |
| Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. | American journal of respiratory and critical care medicine 20091101 |
| Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression. | British journal of pharmacology 20091101 |
| Glucose-regulated protein 78 inhibits scavenger receptor A-mediated internalization of acetylated low density lipoprotein. | Journal of molecular and cellular cardiology 20091101 |
| Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy. | American journal of physiology. Gastrointestinal and liver physiology 20091101 |
| JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease. | Journal of the neurological sciences 20091015 |
| Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. | Archives of biochemistry and biophysics 20091015 |
| Tpl2 is a key mediator of arsenite-induced signal transduction. | Cancer research 20091015 |
| PDGF stimulation of Müller cell proliferation: Contributions of c-JNK and the PI3K/Akt pathway. | Biochemical and biophysical research communications 20091009 |
| Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice. | Journal of reproductive immunology 20091001 |
| JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812 cells. | Free radical biology & medicine 20091001 |
| Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. | Prostaglandins, leukotrienes, and essential fatty acids 20091001 |
| Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. | Toxicology and applied pharmacology 20091001 |
| Anti-apoptotic action of hydrogen sulfide is associated with early JNK inhibition. | Cell biology international 20091001 |
| Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation. | Journal of cellular biochemistry 20091001 |
| Ketoconazole-induced JNK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | Toxicology in vitro : an international journal published in association with BIBRA 20091001 |
| Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells. | Biochimica et biophysica acta 20091001 |
| Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. | Molecular immunology 20091001 |
| A JNK inhibitor SP600125 induces defective cytokinesis and enlargement in P19 embryonal carcinoma cells. | Cell biochemistry and function 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| [Effects of sp600125 on acetaldehyde stimulated hepatic stellate cells]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20091001 |
| JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis. | Experimental & molecular medicine 20090930 |
| SP600125, an inhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin. | Biochemical and biophysical research communications 20090925 |
| JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. | The Journal of biological chemistry 20090925 |
| 1,3-Dinitrobenzene induces apoptosis in TM4 mouse Sertoli cells: Involvement of the c-Jun N-terminal kinase (JNK) MAPK pathway. | Toxicology letters 20090910 |
| FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling. | FEBS letters 20090903 |
| Silencing of TNF-alpha receptors coordinately suppresses TNF-alpha expression through NF-kappaB activation blockade in THP-1 macrophage. | FEBS letters 20090903 |
| Interferon-gamma priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages. | Immunology 20090901 |
| Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. | Molecular biology reports 20090901 |
| Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin. | Oral oncology 20090901 |
| Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism. | Toxicology in vitro : an international journal published in association with BIBRA 20090901 |
| Involvement of C-jun NH2-terminal kinase and apoptosis induced factor in apoptosis induced by deglycosylated bleomycin in laryngeal carcinoma cells. | Cell biology international 20090901 |
| Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner. | Hepatology (Baltimore, Md.) 20090901 |
| Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression. | American journal of physiology. Cell physiology 20090901 |
| The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation. | American journal of physiology. Regulatory, integrative and comparative physiology 20090901 |
| Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. | Molecular cancer research : MCR 20090901 |
| [Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090901 |
| Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1. | Toxicology 20090821 |
| Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells. | Toxicology letters 20090810 |
| Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line. | Environmental toxicology 20090801 |
| Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells. | Biochimica et biophysica acta 20090801 |
| Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. | Biochemical pharmacology 20090801 |
| Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway. | European journal of pharmacology 20090801 |
| Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema. | American journal of physiology. Lung cellular and molecular physiology 20090801 |
| Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. | Annals of the New York Academy of Sciences 20090801 |
| Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. | Annals of the New York Academy of Sciences 20090801 |
| Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. | Annals of the New York Academy of Sciences 20090801 |
| Cobalt protoporphyrin inhibition of lipopolysaccharide or lipoteichoic acid-induced nitric oxide production via blocking c-Jun N-terminal kinase activation and nitric oxide enzyme activity. | Chemico-biological interactions 20090715 |
| Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells. | Toxicology 20090710 |
| Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes. | Molecular and cellular biochemistry 20090701 |
| Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. | Journal of cellular physiology 20090701 |
| Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-kappaB pathways. | International immunopharmacology 20090701 |
| Block-copolymer micelles as carriers of cell signaling modulators for the inhibition of JNK in human islets of Langerhans. | Biomaterials 20090701 |
| Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. | Carcinogenesis 20090701 |
| Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2. | Chemical biology & drug design 20090701 |
| JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090701 |
| Cadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells. | Journal of pharmacological sciences 20090701 |
| Effects of polychlorinated biphenyls on the neutrophil NADPH oxidase system. | Toxicology letters 20090622 |
| NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells. | Toxicology letters 20090622 |
| Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. | The Journal of biological chemistry 20090619 |
| Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes. | Free radical biology & medicine 20090615 |
| Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells. | Toxicology and applied pharmacology 20090615 |
| Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination. | Toxicology and applied pharmacology 20090615 |
| Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy. | Fertility and sterility 20090601 |
| Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. | The international journal of biochemistry & cell biology 20090601 |
| The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes. | Immunopharmacology and immunotoxicology 20090601 |
| Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytes. | Archives of biochemistry and biophysics 20090601 |
| The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma. | Hepatology (Baltimore, Md.) 20090601 |
| Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. | The Journal of clinical investigation 20090601 |
| Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages. | Journal of immunotoxicology 20090601 |
| PHR regulates growth cone pausing at intermediate targets through microtubule disassembly. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090520 |
| Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. | Free radical biology & medicine 20090515 |
| Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. | Toxicology and applied pharmacology 20090515 |
| Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. | Cancer chemotherapy and pharmacology 20090501 |
| JNK and p38 MAPK are independently involved in tributyltin-mediated cell death in rainbow trout (Oncorhynchus mykiss) RTG-2 cells. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090501 |
| JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand. | Gut 20090501 |
| Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase. | The Journal of biological chemistry 20090501 |
| JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125. | The Journal of pathology 20090501 |
| Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase. | Journal of gastroenterology and hepatology 20090501 |
| NaF activates MAPKs and induces apoptosis in odontoblast-like cells. | Journal of dental research 20090501 |
| Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media. | Experimental & molecular medicine 20090430 |
| Inhibition of JNK enhances TGF-beta1-activated Smad2 signaling in mouse embryonic lung. | Pediatric research 20090401 |
| Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. | The Journal of pharmacology and experimental therapeutics 20090401 |
| The TAK1-JNK cascade is required for IRF3 function in the innate immune response. | Cell research 20090401 |
| Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. | Neurobiology of disease 20090401 |
| N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK. | Toxicological sciences : an official journal of the Society of Toxicology 20090401 |
| TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways. | Respirology (Carlton, Vic.) 20090401 |
| Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways. | Placenta 20090401 |
| Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. | American journal of physiology. Cell physiology 20090401 |
| A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. | Nature neuroscience 20090401 |
| Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. | International journal of molecular medicine 20090401 |
| Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway. | The FEBS journal 20090401 |
| Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. | Neuroscience 20090331 |
| Angiotensin II induces MMP 2 activity via FAK/JNK pathway in human endothelial cells. | Biochemical and biophysical research communications 20090320 |
| Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. | Free radical biology & medicine 20090315 |
| Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. | FEBS letters 20090304 |
| Glial fibrillary acidic protein promoter targets pancreatic stellate cells. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090301 |
| Role of mitogen-activated protein kinase cascades in inducible nitric oxide synthase expression by lipopolysaccharide in a rat Schwann cell line. | Neurochemical research 20090301 |
| Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. | Clinica chimica acta; international journal of clinical chemistry 20090301 |
| Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-kappaB pathways. | Toxicology in vitro : an international journal published in association with BIBRA 20090301 |
| Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. | Journal of biochemistry 20090301 |
| Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion. | Toxicology in vitro : an international journal published in association with BIBRA 20090301 |
| Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells. | European journal of pharmacology 20090301 |
| TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells. | FEMS microbiology letters 20090301 |
| C-jun N-terminal kinase-mediated signaling is essential for Staphylococcus aureus-induced U937 apoptosis. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20090301 |
| Role of MAPKs in platinum-induced neuronal apoptosis. | Neurotoxicology 20090301 |
| The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. | Oncogene 20090212 |
| Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation. | Amino acids 20090201 |
| Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. | Journal of cellular physiology 20090201 |
| Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy. | Molecular and cellular biochemistry 20090201 |
| c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. | Carcinogenesis 20090201 |
| Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. | American journal of physiology. Gastrointestinal and liver physiology 20090201 |
| Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. | Biomedical and environmental sciences : BES 20090201 |
| SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression. | FEBS letters 20090105 |
| 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | Journal of vascular research 20090101 |
| TNF-alpha production in the skin. | Archives of dermatological research 20090101 |
| Enhanced induction of LPS-induced fibroblast MCP-1 by interferon-gamma: involvement of JNK and MAPK phosphatase-1. | Cellular immunology 20090101 |
| AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. | Virus research 20090101 |
| Oxidative stress resistance through blocking Hsp60 translocation followed by SAPK/JNK inhibition in aged human diploid fibroblasts. | Cell biochemistry and function 20090101 |
| Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090101 |
| Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes. | Journal of pharmacological sciences 20090101 |
| Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice. | Journal of pharmacological sciences 20090101 |
| Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways. | Molecular vision 20090101 |
| Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells. | Immunobiology 20090101 |
| The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. | The Journal of international medical research 20090101 |
| The JNK pathway amplifies and drives subcellular changes in tau phosphorylation. | Neuropharmacology 20090101 |
| Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. | PloS one 20090101 |
| The proliferation and migration effects of huangqi on RSC96 Schwann cells. | The American journal of Chinese medicine 20090101 |
| Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis. | Scandinavian journal of gastroenterology 20090101 |
| Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin. | Experimental & molecular medicine 20081231 |
| Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells. | Chinese medical journal 20081220 |
| Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation. | Cancer research 20081215 |
| Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements. | Molecular and cellular biochemistry 20081201 |
| Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells. | Cell biology international 20081201 |
| Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. | Neuropharmacology 20081201 |
| o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways. | Toxicology and applied pharmacology 20081201 |
| Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis. | Neurobiology of disease 20081201 |
| In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. | Apoptosis : an international journal on programmed cell death 20081201 |
| Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion. | Metabolism: clinical and experimental 20081201 |
| [Impact of PTEN gene knockout in human breast carcinoma MCF-7 cells on activity of JNK pathway]. | Ai zheng = Aizheng = Chinese journal of cancer 20081201 |
| [The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081201 |
| Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells. | Journal of endocrinological investigation 20081201 |
| JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation. | Biochemical and biophysical research communications 20081128 |
| Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells. | FEBS letters 20081126 |
| Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach. | Journal of medicinal chemistry 20081113 |
| Selenium attenuates pro-inflammatory gene expression in macrophages. | Molecular nutrition & food research 20081101 |
| Egr-1 mRNA induction by medium flow involves mRNA stabilization and is enhanced by the p38 inhibitor SB203580 in osteoblast-like cells. | Acta physiologica (Oxford, England) 20081101 |
| Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. | Journal of cellular physiology 20081101 |
| IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts. | Journal of cellular physiology 20081101 |
| Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. | Gut 20081101 |
| Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. | Experimental cell research 20081101 |
| Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling. | The Journal of steroid biochemistry and molecular biology 20081101 |
| Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues. | Spine 20081101 |
| Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. | Pain 20081031 |
| Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1. | The Journal of biological chemistry 20081031 |
| IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells. | Immunology letters 20081030 |
| The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. | Journal of cellular physiology 20081001 |
| (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-stimulated interleukin-6 synthesis in osteoblasts. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081001 |
| Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro. | Histochemistry and cell biology 20081001 |
| TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells. | Cancer investigation 20081001 |
| The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism. | Molecular pharmacology 20081001 |
| A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. | Leukemia 20081001 |
| Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. | Free radical biology & medicine 20081001 |
| A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation. | Lung cancer (Amsterdam, Netherlands) 20080901 |
| Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling. | The Journal of pharmacology and experimental therapeutics 20080901 |
| 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. | Biochemical and biophysical research communications 20080829 |
| Activation of endothelial cells to pathological status by down-regulation of connexin43. | Cardiovascular research 20080801 |
| Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801 |
| Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. | The Biochemical journal 20080801 |
| Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. | The Journal of biological chemistry 20080801 |
| Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways. | Toxicology and applied pharmacology 20080801 |
| The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease. | Neuroscience research 20080801 |
| JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis. | Pigment cell & melanoma research 20080801 |
| BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn. | Experimental neurology 20080801 |
| Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart. | The Journal of experimental biology 20080801 |
| Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. | Oncology reports 20080801 |
| P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state. | FEBS letters 20080723 |
| Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. | The Journal of nutritional biochemistry 20080701 |
| Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the generation of reactive oxygen species. | Endocrinology 20080701 |
| JNK as a positive regulator of angiogenic potential in endothelial cells. | Cell biology international 20080701 |
| Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors. | American journal of physiology. Heart and circulatory physiology 20080701 |
| c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. | Cancer research 20080701 |
| Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms. | Molecular cancer therapeutics 20080701 |
| Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. | Experimental & molecular medicine 20080630 |
| Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells. | Cancer letters 20080618 |
| The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080601 |
| Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts. | Toxicological sciences : an official journal of the Society of Toxicology 20080601 |
| Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells. | FEMS microbiology letters 20080601 |
| Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20080601 |
| 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells. | Free radical research 20080601 |
| Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor. | General physiology and biophysics 20080601 |
| [Redox-dependent regulation of apoptosis as a function of intracellular reactive oxygen species in oxidative stress]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080601 |
| Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. | The Journal of biological chemistry 20080516 |
| JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. | American journal of physiology. Endocrinology and metabolism 20080501 |
| Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. | Laboratory investigation; a journal of technical methods and pathology 20080501 |
| Cruzipain and SP600125 induce p38 activation, alter NO/arginase balance and favor the survival of Trypanosoma cruzi in macrophages. | Acta tropica 20080501 |
| In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. | Anesthesia and analgesia 20080501 |
| The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells. | Cancer biology & therapy 20080501 |
| Role of recombinant mitogen-activated protein kinases JNK and p38 in the regulation of apoptosis in blood mononuclear cells under conditions of oxidative stress in vitro. | Bulletin of experimental biology and medicine 20080501 |
| Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells. | Toxicology 20080418 |
| Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells. | Toxicology and applied pharmacology 20080415 |
| Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). | Bioorganic & medicinal chemistry 20080415 |
| MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. | Journal of neurochemistry 20080401 |
| Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats. | Biochimica et biophysica acta 20080401 |
| Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. | The FEBS journal 20080401 |
| Anti-fas activating antibody enhances trophoblast outgrowth on endometrial epithelial cells by induction of P38 MAPK/JNK-mediated apoptosis. | Placenta 20080401 |
| Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. | Free radical research 20080401 |
| Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080401 |
| [Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080401 |
| Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS. | Innate immunity 20080401 |
| Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD. | Toxicology and applied pharmacology 20080315 |
| Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1. | Toxicology letters 20080315 |
| Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080315 |
| Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20080301 |
| The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper. | Free radical biology & medicine 20080301 |
| Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice. | Hepatology (Baltimore, Md.) 20080301 |
| Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells. | FEMS immunology and medical microbiology 20080301 |
| Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro. | American journal of obstetrics and gynecology 20080301 |
| Role of mitogen-activated protein kinases in the iNOS production and cytokine secretion by Salmonella enterica serovar Typhimurium porins. | Cytokine 20080301 |
| Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells. | American journal of physiology. Cell physiology 20080301 |
| p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. | Cancer research 20080301 |
| Stress-activated protein kinase inhibition to ameliorate lung ischemia reperfusion injury. | The Journal of thoracic and cardiovascular surgery 20080301 |
| MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells. | Life sciences 20080227 |
| SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells. | Biochemical and biophysical research communications 20080222 |
| The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. | Virology 20080220 |
| c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway. | Journal of cellular biochemistry 20080215 |
| Interleukin-1beta gene in orange-spotted grouper, Epinephelus coioides: molecular cloning, expression, biological activities and signal transduction. | Molecular immunology 20080201 |
| c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons. | Journal of neurochemistry 20080201 |
| Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells. | Molecular and cellular biochemistry 20080201 |
| JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC. | Experimental cell research 20080201 |
| Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta. | Scandinavian journal of immunology 20080201 |
| Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK. | The EMBO journal 20080123 |
| JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes. | Biochemical pharmacology 20080115 |
| Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation. | Cell cycle (Georgetown, Tex.) 20080115 |
| 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. | Biochemistry 20080108 |
| Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. | Cell biology international 20080101 |
| c-Jun N-terminal kinase inhibitor II (SP600125) activates Mullerian inhibiting substance type II receptor-mediated signal transduction. | Endocrinology 20080101 |
| Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors. | Experimental hematology 20080101 |
| Inhibitors of c-Jun N-terminal kinases: JuNK no more? | Biochimica et biophysica acta 20080101 |
| Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure. | Investigative ophthalmology & visual science 20080101 |
| High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities. | The Journal of endocrinology 20080101 |
| Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri. | Free radical research 20080101 |
| Inhibition of c-Jun N-terminal kinase pathway attenuates cerebral vasospasm after experimental subarachnoid hemorrhage through the suppression of apoptosis. | Acta neurochirurgica. Supplement 20080101 |
| Membrane initiated signaling by 1,25alpha-dihydroxyvitamin D3 in LNCaP prostate cancer cells. | Advances in experimental medicine and biology 20080101 |
| JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin. | Journal of inflammation (London, England) 20080101 |
| Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts. | Journal of bone and mineral metabolism 20080101 |
| NF-kappaB and AP-1 are key signaling pathways in the modulation of NAD(P)H:quinone oxidoreductase 1 gene by mercury, lead, and copper. | Journal of biochemical and molecular toxicology 20080101 |
| Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20080101 |
| Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. | BMC cardiovascular disorders 20080101 |
| Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes. | Immunological investigations 20080101 |
| Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells. | Journal of experimental & clinical cancer research : CR 20080101 |
| Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways. | Molecular vision 20071221 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes. | Biochemical and biophysical research communications 20071207 |
| MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201 |
| Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. | Journal of pharmacological sciences 20071201 |
| Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. | European journal of pharmacology 20071114 |
| Berberine-induced LDLR up-regulation involves JNK pathway. | Biochemical and biophysical research communications 20071103 |
| EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase. | Toxicology and applied pharmacology 20071101 |
| Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells. | Neurochemical research 20071101 |
| Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. | The Biochemical journal 20071101 |
| Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation. | Toxicological sciences : an official journal of the Society of Toxicology 20071101 |
| Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. | Molecular pharmacology 20071101 |
| Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases. | Molecular and cellular neurosciences 20071101 |
| Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone. | Apoptosis : an international journal on programmed cell death 20071101 |
| Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells. | The Journal of biological chemistry 20071012 |
| Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. | The Journal of biological chemistry 20071012 |
| Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells. | FEBS letters 20071002 |
| Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells. | Leukemia research 20071001 |
| Patterns of kinase activation induced by injury in the murine femoral artery. | The Journal of surgical research 20071001 |
| Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20071001 |
| Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. | Drug metabolism and pharmacokinetics 20071001 |
| House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells. | Journal of Korean medical science 20071001 |
| Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins. | The Journal of biological chemistry 20070928 |
| Manganese chloride stimulates rat microglia to release hydrogen peroxide. | Toxicology letters 20070910 |
| Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells. | Toxicology 20070905 |
| IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells. | Journal of cellular physiology 20070901 |
| Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury. | Cellular signalling 20070901 |
| Inhibition of c-Jun N-terminal kinase in the CA1 region of the dorsal hippocampus blocks extinction of inhibitory avoidance memory. | Behavioural pharmacology 20070901 |
| Ras pathway activation in malignant mesothelioma. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070901 |
| Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. | Free radical biology & medicine 20070815 |
| Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. | The Journal of biological chemistry 20070803 |
| Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis. | Annals of the rheumatic diseases 20070801 |
| Effect of JNK inhibition on cisplatin-induced renal damage. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801 |
| Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells. | International immunopharmacology 20070801 |
| Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. | International immunopharmacology 20070801 |
| Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia. | International immunopharmacology 20070801 |
| Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells. | The Journal of endocrinology 20070801 |
| Expression and function of mixed lineage kinases in dendritic cells. | International immunology 20070801 |
| [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070801 |
| Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism. | The Biochemical journal 20070715 |
| c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. | Neuroscience 20070713 |
| PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK. | Neuroscience letters 20070705 |
| Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. | Gut 20070701 |
| Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. | Carcinogenesis 20070701 |
| Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. | Endocrinology 20070701 |
| Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. | The Journal of pharmacology and experimental therapeutics 20070701 |
| TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells. | Cell cycle (Georgetown, Tex.) 20070615 |
| Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK. | Cancer letters 20070608 |
| Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. | Biochemical and biophysical research communications 20070608 |
| Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes. | Neurochemistry international 20070601 |
| Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity. | Journal of cellular biochemistry 20070601 |
| Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. | International journal of cancer 20070601 |
| Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. | European journal of pharmacology 20070601 |
| Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. | Cancer research 20070601 |
| Suppression of alloreactivity and allograft rejection by SP600125, a small molecule inhibitor of c-Jun N-terminal kinase. | Transplantation 20070527 |
| The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. | The Journal of biological chemistry 20070518 |
| SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis. | Life sciences 20070508 |
| Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase. | Brain research 20070507 |
| c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. | Biochemical and biophysical research communications 20070504 |
| Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B. | Archives of toxicology 20070501 |
| Inhibitory effect of TNF-alpha on the intestinal absorption of galactose. | Journal of cellular biochemistry 20070501 |
| P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. | Cellular signalling 20070501 |
| c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. | Cell death and differentiation 20070501 |
| Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. | Molecular pharmacology 20070501 |
| The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. | Laboratory investigation; a journal of technical methods and pathology 20070501 |
| IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. | Critical care medicine 20070501 |
| Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1. | Experimental biology and medicine (Maywood, N.J.) 20070501 |
| [CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070501 |
| Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses. | Molecules and cells 20070430 |
| Kinetic characterization of human JNK2alpha2 reaction mechanism using substrate competitive inhibitors. | Biochemistry 20070424 |
| (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation. | FEBS letters 20070403 |
| Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells. | FEBS letters 20070403 |
| Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. | Molecular and cellular biochemistry 20070401 |
| Inhibition of JNK activation prolongs survival after smoke inhalation from fires. | American journal of physiology. Lung cellular and molecular physiology 20070401 |
| TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new 'hot' cancer treatment. | Biochimica et biophysica acta 20070401 |
| Interleukin-1 mediates thermal injury-induced lung damage through C-Jun NH2-terminal kinase signaling. | Critical care medicine 20070401 |
| Interleukin-1 in thermal injury: what is next? | Critical care medicine 20070401 |
| Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway. | Lasers in surgery and medicine 20070401 |
| c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms. | Neuroscience 20070330 |
| Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. | European journal of pharmacology 20070322 |
| An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins. | Life sciences 20070313 |
| Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. | Journal of leukocyte biology 20070301 |
| Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070301 |
| REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. | International journal of molecular medicine 20070301 |
| Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2. | Journal of biochemistry 20070301 |
| Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth. | Biochemical and biophysical research communications 20070216 |
| p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. | Biochemical and biophysical research communications 20070216 |
| Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070215 |
| Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207 |
| Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells. | European journal of pharmacology 20070205 |
| Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats. | Cell death and differentiation 20070201 |
| Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death. | Journal of leukocyte biology 20070201 |
| A novel pathway for transcriptional regulation of alpha-synuclein. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201 |
| The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. | Hepatology (Baltimore, Md.) 20070201 |
| Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20070201 |
| Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. | British journal of cancer 20070115 |
| Neurotoxicity assessment using zebrafish. | Journal of pharmacological and toxicological methods 20070101 |
| Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. | Biochemical pharmacology 20070101 |
| Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress. | Apoptosis : an international journal on programmed cell death 20070101 |
| JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1. | The European journal of neuroscience 20070101 |
| Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. | Thrombosis research 20070101 |
| Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis. | Journal of vascular research 20070101 |
| c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability. | BMC cell biology 20070101 |
| The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101 |
| UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures. | BMC plant biology 20070101 |
| Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts. | Biochemical and biophysical research communications 20061229 |
| Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. | Cancer letters 20061208 |
| Involvement of MAP kinases in lipopolysaccharide-induced histamine production in RAW 264 cells. | Life sciences 20061203 |
| Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis. | Cell death and differentiation 20061201 |
| Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions. | Cellular signalling 20061201 |
| Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. | Journal of cellular physiology 20061201 |
| The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells. | British journal of haematology 20061201 |
| Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. | European journal of immunology 20061201 |
| JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. | Hepatology (Baltimore, Md.) 20061201 |
| Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors. | Cancer research 20061201 |
| Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model. | The Laryngoscope 20061201 |
| In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20061201 |
| [Amelioration of insulin resistance after scald by c-Jun N-terminal kinase inhibitor in rat]. | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20061201 |
| [The role of MAPK/ERK1/2 signaling pathway in aldosterone stimulated transforming growth factor-beta1 synthesis in renal tubular epithelial cells]. | Zhonghua yi xue za zhi 20061128 |
| Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). | Life sciences 20061125 |
| Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes. | Toxicology and applied pharmacology 20061115 |
| Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. | Oncogene 20061109 |
| Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. | Carcinogenesis 20061101 |
| Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells. | Apoptosis : an international journal on programmed cell death 20061101 |
| Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. | Journal of thrombosis and haemostasis : JTH 20061101 |
| P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells. | Apoptosis : an international journal on programmed cell death 20061101 |
| Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. | Development (Cambridge, England) 20061101 |
| Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. | Journal of immunology (Baltimore, Md. : 1950) 20061101 |
| Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms. | Molecular pharmacology 20061001 |
| Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. | Leukemia 20061001 |
| Regulation by Jun N-terminal kinase/stress activated protein kinase of cytokine expression in Mycobacterium avium subsp paratuberculosis-infected bovine monocytes. | American journal of veterinary research 20061001 |
| Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line. | Biochimica et biophysica acta 20061001 |
| Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. | Cancer letters 20060928 |
| Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation. | The Journal of surgical research 20060901 |
| Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction. | The Journal of clinical endocrinology and metabolism 20060901 |
| p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis. | Biochemical and biophysical research communications 20060901 |
| Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125. | Genes to cells : devoted to molecular & cellular mechanisms 20060901 |
| PPARgamma phosphorylation mediated by JNK MAPK: a potential role in macrophage-derived foam cell formation. | Acta pharmacologica Sinica 20060901 |
| Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. | Arthritis and rheumatism 20060901 |
| SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury. | Experimental & molecular medicine 20060831 |
| Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death. | Experimental & molecular medicine 20060831 |
| Acquired tolerance in cadmium-adapted lung epithelial cells: roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein. | Toxicology and applied pharmacology 20060815 |
| atRA-induced apoptosis of mouse embryonic palate mesenchymal cells involves activation of MAPK pathway. | Toxicology and applied pharmacology 20060815 |
| TNFalpha and GM-CSF-induced activation of the CAEV promoter is independent of AP-1. | Virology 20060815 |
| Ligustilide inhibits vascular smooth muscle cells proliferation. | European journal of pharmacology 20060807 |
| Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein. | Toxicology and applied pharmacology 20060801 |
| Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis. | Toxicological sciences : an official journal of the Society of Toxicology 20060801 |
| Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. | Toxicological sciences : an official journal of the Society of Toxicology 20060801 |
| Esculetin induces mitochondria-mediated apoptosis in 3T3-L1 adipocytes. | Apoptosis : an international journal on programmed cell death 20060801 |
| c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. | Free radical biology & medicine 20060801 |
| Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. | Prostaglandins, leukotrienes, and essential fatty acids 20060801 |
| c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20060801 |
| p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells. | Brain research 20060712 |
| Manganese modulates pro-inflammatory gene expression in activated glia. | Neurochemistry international 20060701 |
| Nuclear factor-kappa B-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway. | The Journal of pharmacology and experimental therapeutics 20060701 |
| Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells. | Apoptosis : an international journal on programmed cell death 20060701 |
| Perfusion-culture-based secreted bioluminescence reporter assay in living cells. | Analytical biochemistry 20060701 |
| Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060701 |
| c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. | Gastroenterology 20060701 |
| Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. | The Journal of biological chemistry 20060630 |
| Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway. | Oncogene 20060622 |
| Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060614 |
| Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells. | Archives of toxicology 20060601 |
| JNK inhibitor SP600125 reduces COX-2 expression by attenuating mRNA in activated murine J774 macrophages. | International immunopharmacology 20060601 |
| Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells. | Molecular cancer research : MCR 20060601 |
| Dracorhodin perchlorate induces apoptosis in HL-60 cells. | Journal of Asian natural products research 20060601 |
| Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. | Brain research 20060530 |
| Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. | Experimental cell research 20060515 |
| Regression of aortic aneurysms through pharmacologic therapy? | The New England journal of medicine 20060511 |
| Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury. | Neuroscience letters 20060508 |
| N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. | Oncogene 20060504 |
| Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503 |
| Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells. | Carcinogenesis 20060501 |
| Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases. | Journal of hepatology 20060501 |
| Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20060501 |
| Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells. | Neuroscience letters 20060501 |
| Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells. | Molecular pharmacology 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing. | European journal of immunology 20060501 |
| The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. | Immunology 20060501 |
| MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells. | Brain research 20060501 |
| The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox. | Free radical biology & medicine 20060415 |
| The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. | International journal of oncology 20060401 |
| Involvement of protein kinases on the upregulation of endothelin receptors in rat basilar and mesenteric arteries. | Experimental biology and medicine (Maywood, N.J.) 20060401 |
| Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA. | The Journal of endocrinology 20060401 |
| S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism. | World journal of gastroenterology 20060328 |
| Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species. | Journal of cell science 20060315 |
| Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. | Molecular and cellular endocrinology 20060309 |
| Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells. | World journal of gastroenterology 20060307 |
| Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. | Toxicological sciences : an official journal of the Society of Toxicology 20060301 |
| Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster. | Cardiovascular research 20060301 |
| Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301 |
| Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease. | International journal of molecular medicine 20060301 |
| Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest. | Thyroid : official journal of the American Thyroid Association 20060301 |
| FADD phosphorylation is critical for cell cycle regulation in breast cancer cells. | British journal of cancer 20060227 |
| Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling. | Biochemistry 20060221 |
| Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase. | Cardiovascular research 20060215 |
| As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells. | Cellular signalling 20060201 |
| A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. | Journal of lipid research 20060201 |
| Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line. | Journal of leukocyte biology 20060201 |
| Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. | Cardiovascular research 20060201 |
| The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis. | International immunopharmacology 20060201 |
| Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways. | Journal of periodontal research 20060201 |
| Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3. | Cancer research 20060201 |
| c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle. | Journal of pharmacological sciences 20060201 |
| Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway. | Neuroscience letters 20060130 |
| Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. | FEBS letters 20060123 |
| NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. | Biochemical and biophysical research communications 20060106 |
| Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. | Journal of biomedical science 20060101 |
| c-Jun NH2-terminal kinase mediates interleukin-1beta-induced inhibition of lacrimal gland secretion. | Journal of neurochemistry 20060101 |
| c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production. | Journal of neuroscience research 20060101 |
| Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. | Free radical biology & medicine 20060101 |
| NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. | Journal of immunology (Baltimore, Md. : 1950) 20060101 |
| Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA. | Cellular microbiology 20060101 |
| Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats. | Clinical and experimental immunology 20060101 |
| Thermal injury-induced peroxynitrite production and pulmonary inducible nitric oxide synthase expression depend on JNK/AP-1 signaling. | Critical care medicine 20060101 |
| [Effects of sp600125 on proliferation and protein expression of bcl-2 and c-myc in hepatic stellate cells]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060101 |
| Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. | Basic & clinical pharmacology & toxicology 20060101 |
| Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression. | BMC pharmacology 20060101 |
| Inhibition of UVA-induced c-Jun N-terminal kinase activity results in caspase-dependent apoptosis in human keratinocytes. | Photochemistry and photobiology 20060101 |
| C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. | Antioxidants & redox signaling 20060101 |
| Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells. | Respiratory research 20060101 |
| Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | Arthritis research & therapy 20060101 |
| JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages. | Mediators of inflammation 20060101 |
| Up-regulation of P-glycoprotein expression by catalase via JNK activation in HepG2 cells. | Redox report : communications in free radical research 20060101 |
| Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. | Cancer research 20051215 |
| Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. | Cellular signalling 20051201 |
| Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals. | Archives of toxicology 20051201 |
| Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. | American journal of physiology. Gastrointestinal and liver physiology 20051201 |
| KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells. | Journal of lipid research 20051201 |
| Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. | Nature medicine 20051201 |
| Aneurysm treatments expand. | Nature medicine 20051201 |
| X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). | The Journal of biological chemistry 20051118 |
| Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. | The Journal of biological chemistry 20051118 |
| Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1. | Toxicology and applied pharmacology 20051115 |
| The role of p38 MAP kinase and c-Jun N-terminal protein kinase signaling in the differentiation and apoptosis of immortalized neural stem cells. | Mutation research 20051111 |
| Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. | Leukemia 20051101 |
| Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide-stimulated human monocytic cells. | Journal of immunology (Baltimore, Md. : 1950) 20051101 |
| Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants. | Expert opinion on investigational drugs 20051101 |
| [Role of MAPK in the migration of human coronary artery smooth muscle cell into three-dimensional fibrin gel]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101 |
| Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. | Mediators of inflammation 20051024 |
| The role of p-c-Jun in survival and outgrowth of developing sensory neurons. | Neuroreport 20051017 |
| Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells. | Life sciences 20051014 |
| Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland. | Brain research. Molecular brain research 20051003 |
| Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. | European journal of pharmacology 20051003 |
| Effects of the JNK inhibitor anthra[1,9-cd]pyrazol-6(2H)-one (SP-600125) on soluble guanylyl cyclase alpha1 gene regulation and cGMP synthesis. | American journal of physiology. Cell physiology 20051001 |
| Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity. | Cellular signalling 20051001 |
| Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. | Cellular signalling 20051001 |
| Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells. | Arteriosclerosis, thrombosis, and vascular biology 20051001 |
| Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite. | Molecular and cellular biology 20051001 |
| JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. | Cellular and molecular life sciences : CMLS 20051001 |
| Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. | The Journal of clinical investigation 20051001 |
| Mitomycin-C induces the apoptosis of human Tenon's capsule fibroblast by activation of c-Jun N-terminal kinase 1 and caspase-3 protease. | Investigative ophthalmology & visual science 20051001 |
| Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1. | The Journal of biological chemistry 20050923 |
| c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. | Biochemical and biophysical research communications 20050916 |
| Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. | Molecular biology of the cell 20050901 |
| Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells. | Journal of toxicology and environmental health. Part A 20050901 |
| Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells. | Cell cycle (Georgetown, Tex.) 20050901 |
| Ablation of the spindle assembly checkpoint by a compound targeting Mps1. | EMBO reports 20050901 |
| Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation. | Arthritis and rheumatism 20050901 |
| Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB. | American journal of respiratory cell and molecular biology 20050801 |
| Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | Bone 20050801 |
| HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. | Free radical biology & medicine 20050801 |
| Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts. | Placenta 20050801 |
| Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. | Journal of neurochemistry 20050801 |
| Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest. | Cancer research 20050801 |
| Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes. | Archives of pharmacal research 20050801 |
| Histamine induces tissue factor expression: implications for acute coronary syndromes. | Circulation 20050719 |
| Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. | Biochemical and biophysical research communications 20050715 |
| Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines. | Free radical biology & medicine 20050715 |
| Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells. | Cancer research 20050715 |
| Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway. | Life sciences 20050708 |
| P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis. | Journal of cellular biochemistry 20050701 |
| CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway. | Experimental cell research 20050701 |
| Polypeptide from Chlamys farreri inhibits murine thymocytes apoptosis and modulates UVB induced signaling pathway activation. | Life sciences 20050701 |
| Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage. | Stroke 20050701 |
| Inflammatory responses of corneal epithelial cells to Pseudomonas aeruginosa infection. | Current eye research 20050701 |
| Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. | The Journal of biological chemistry 20050617 |
| Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors. | Archives of biochemistry and biophysics 20050615 |
| Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. | Toxicology and applied pharmacology 20050615 |
| Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. | Biochemical and biophysical research communications 20050603 |
| c-Jun NH2-terminal kinase mediation of angiotensin II-induced proliferation of human mesangial cells. | American journal of physiology. Renal physiology 20050601 |
| Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050601 |
| Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells. | Journal of neuroscience research 20050601 |
| DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. | Molecular and cellular biology 20050601 |
| Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. | The Journal of endocrinology 20050601 |
| Inflammatory pathway analysis using a high content screening platform. | Assay and drug development technologies 20050601 |
| Activation of c-Jun N-terminal kinase is required for neurite outgrowth of dopaminergic neuronal cells. | Neuroreport 20050531 |
| 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. | Oncogene 20050526 |
| Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina. | Brain research 20050524 |
| Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. | The Journal of biological chemistry 20050513 |
| Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta. | American journal of respiratory cell and molecular biology 20050501 |
| Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx. | American journal of respiratory and critical care medicine 20050501 |
| Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages. | International immunopharmacology 20050501 |
| Pepsin-digested bovine lactoferrin induces apoptotic cell death with JNK/SAPK activation in oral cancer cells. | Journal of pharmacological sciences 20050501 |
| c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413 |
| Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation. | Life sciences 20050408 |
| Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. | The Journal of pharmacology and experimental therapeutics 20050401 |
| Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. | Biochemical and biophysical research communications 20050401 |
| Cigarette smoke extract induces endothelial cell injury via JNK pathway. | Biochemical and biophysical research communications 20050401 |
| Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. | The Journal of allergy and clinical immunology 20050401 |
| Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha. | Oncogene 20050331 |
| Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth. | Virology 20050315 |
| A small molecule-kinase interaction map for clinical kinase inhibitors. | Nature biotechnology 20050301 |
| Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. | Molecular cancer therapeutics 20050301 |
| SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050301 |
| The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways. | Brain research 20050221 |
| Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202 |
| Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum. | Cellular signalling 20050201 |
| Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line. | Cellular signalling 20050201 |
| Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways. | Arteriosclerosis, thrombosis, and vascular biology 20050201 |
| c-Jun N-terminal kinase is involved in mercuric ions-mediated interleukin-4 secretion in mast cells. | International archives of allergy and immunology 20050201 |
| Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. | European journal of pharmacology 20050131 |
| Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. | Toxicology 20050115 |
| Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha. | Toxicology 20050115 |
| Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase. | Biochemical and biophysical research communications 20050114 |
| Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125. | European journal of pharmacology 20050104 |
| Synthesis of the Na-K-ATPase gamma-subunit is regulated at both the transcriptional and translational levels in IMCD3 cells. | American journal of physiology. Renal physiology 20050101 |
| Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. | Hypertension (Dallas, Tex. : 1979) 20050101 |
| Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. | Neurobiology of aging 20050101 |
| Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. | Gastroenterology 20050101 |
| Interleukin-1beta-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK. | Nephron. Experimental nephrology 20050101 |
| Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons. | Neuroscience 20050101 |
| Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. | Respiratory research 20050101 |
| JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. | The Journal of biological chemistry 20041231 |
| Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells. | Experimental & molecular medicine 20041231 |
| Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages. | Free radical biology & medicine 20041215 |
| p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling. | Journal of cell science 20041215 |
| c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. | Cancer research 20041215 |
| Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways. | American journal of physiology. Cell physiology 20041201 |
| Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. | International immunology 20041201 |
| Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20041201 |
| Induction of serine racemase by inflammatory stimuli is dependent on AP-1. | Annals of the New York Academy of Sciences 20041201 |
| Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase. | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20041201 |
| KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation. | The Japanese journal of physiology 20041201 |
| c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). | Oncogene 20041125 |
| Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. | Molecular cell 20041119 |
| UV-induced apoptosis in SH-SY5Y cells: contribution to apoptosis by JNK signaling and cytochrome c. | Journal of neuroscience research 20041115 |
| Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy. | Journal of immunology (Baltimore, Md. : 1950) 20041115 |
| Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. | Circulation research 20041112 |
| Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110 |
| Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. | Biochemical and biophysical research communications 20041105 |
| Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways. | Brain research. Molecular brain research 20041104 |
| Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. | Carcinogenesis 20041101 |
| Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons. | Molecular and cellular neurosciences 20041101 |
| Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis. | American journal of reproductive immunology (New York, N.Y. : 1989) 20041101 |
| Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. | Life sciences 20041029 |
| Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041015 |
| Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells. | Journal of applied physiology (Bethesda, Md. : 1985) 20041001 |
| Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. | Endocrinology 20041001 |
| Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages. | Toxicological sciences : an official journal of the Society of Toxicology 20041001 |
| MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury. | Journal of cellular physiology 20041001 |
| Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. | Journal of biomechanics 20041001 |
| High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | The Journal of veterinary medical science 20041001 |
| Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. | Brain research 20040924 |
| Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. | European journal of pharmacology 20040913 |
| Regulation of tumor necrosis factor-alpha in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway. | Toxicology letters 20040910 |
| Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. | Neuroscience letters 20040909 |
| The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908 |
| Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. | Circulation 20040907 |
| Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. | The Journal of general virology 20040901 |
| Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | Molecular pharmacology 20040901 |
| Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways. | Circulation research 20040820 |
| Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. | The Journal of clinical investigation 20040816 |
| p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells. | Biochemical and biophysical research communications 20040806 |
| A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells. | The Journal of pharmacology and experimental therapeutics 20040801 |
| Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines. | Blood 20040801 |
| JNK MAP kinase is involved in the humoral immune response of the greater wax moth larvae Galleria mellonella. | Archives of insect biochemistry and physiology 20040801 |
| Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801 |
| The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. | The Journal of biological chemistry 20040730 |
| Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. | The Journal of biological chemistry 20040716 |
| Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. | Experimental cell research 20040715 |
| Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells. | European journal of pharmacology 20040714 |
| JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes. | Cellular signalling 20040701 |
| Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway. | Cardiovascular research 20040701 |
| Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats. | Immunology 20040701 |
| C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20040701 |
| Macrophage-mediated renal injury is dependent on signaling via the JNK pathway. | Journal of the American Society of Nephrology : JASN 20040701 |
| Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. | Molecular cancer therapeutics 20040701 |
| Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner. | Circulation research 20040611 |
| Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. | Oncogene 20040603 |
| Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. | The EMBO journal 20040602 |
| BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists. | The EMBO journal 20040602 |
| Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. | Journal of the American Society of Nephrology : JASN 20040601 |
| Involvement of SAPK/JNK in prostaglandin E(1)-induced VEGF synthesis in osteoblast-like cells. | Molecular and cellular endocrinology 20040531 |
| Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway. | The Journal of biological chemistry 20040521 |
| Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2alpha-induced heat shock protein 27 in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20040501 |
| The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. | Experimental cell research 20040501 |
| Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells. | Journal of cellular biochemistry 20040501 |
| Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes. | The Journal of nutritional biochemistry 20040501 |
| Involvement of ROS and JNK1 in selenite-induced apoptosis in Chang liver cells. | Experimental & molecular medicine 20040430 |
| JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. | The Journal of biological chemistry 20040423 |
| Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells. | Toxicology and applied pharmacology 20040415 |
| Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401 |
| The role of c-Jun N-terminal kinase in the A beta-mediated impairment of LTP and regulation of synaptic transmission in the hippocampus. | Neuropharmacology 20040401 |
| MAPK signaling pathways modulate IL-1beta expression in human keratinocytes. | Archives of biochemistry and biophysics 20040401 |
| Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells. | Journal of cellular biochemistry 20040401 |
| Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation. | Molecular pharmacology 20040401 |
| Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331 |
| Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. | The Journal of biological chemistry 20040319 |
| Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. | The Journal of biological chemistry 20040319 |
| Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. | Biochimica et biophysica acta 20040311 |
| Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways. | The Journal of biological chemistry 20040305 |
| Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition. | Molecular and cellular biochemistry 20040301 |
| Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol. | Molecular cancer research : MCR 20040301 |
| Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase. | American journal of respiratory and critical care medicine 20040215 |
| Bcl-2 enhances neurite extension via activation of c-Jun N-terminal kinase. | Biochemical and biophysical research communications 20040206 |
| Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase. | Biochemical and biophysical research communications 20040206 |
| c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart. | American journal of physiology. Heart and circulatory physiology 20040201 |
| DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung. | American journal of physiology. Lung cellular and molecular physiology 20040201 |
| SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. | Neuroscience research 20040201 |
| Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells. | Molecular cancer research : MCR 20040201 |
| 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. | The Journal of biological chemistry 20040130 |
| All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells. | Oncogene 20040115 |
| Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death. | European journal of pharmacology 20040112 |
| An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase. | The Journal of biological chemistry 20040109 |
| Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107 |
| Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. | The Journal of biological chemistry 20040102 |
| Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. | Carcinogenesis 20040101 |
| Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. | Carcinogenesis 20040101 |
| Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells. | Cancer research 20040101 |
| Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells. | In vivo (Athens, Greece) 20040101 |
| Characterization of Cd-induced molecular events prior to cellular damage in primary rat hepatocytes in culture: activation of the stress activated signal protein JNK and transcription factor AP-1. | Journal of biochemical and molecular toxicology 20040101 |
| Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury. | Respiratory research 20040101 |
| p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons. | Neuroscience letters 20031226 |
| IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase. | Cellular signalling 20031201 |
| Verotoxin activates mitogen-activated protein kinase in human peripheral blood monocytes: role in apoptosis and proinflammatory cytokine release. | British journal of pharmacology 20031201 |
| Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase. | British journal of pharmacology 20031201 |
| Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). | Toxicology and applied pharmacology 20031201 |
| N-nitrosocarbofuran induces apoptosis in mouse brain microvascular endothelial cells (bEnd.3). | Journal of pharmacological sciences 20031201 |
| Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. | Oncogene 20031127 |
| Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis. | International journal of cancer 20031120 |
| Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation. | FEBS letters 20031120 |
| C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect. | Transplantation 20031115 |
| Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells. | Cytokine 20031107 |
| Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase. | American journal of physiology. Regulatory, integrative and comparative physiology 20031101 |
| The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. | Drug metabolism and disposition: the biological fate of chemicals 20031101 |
| Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes. | Toxicology and applied pharmacology 20031101 |
| Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031101 |
| Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. | The Journal of biological chemistry 20031010 |
| Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. | Neuropharmacology 20031001 |
| Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus. | Insect molecular biology 20031001 |
| Inhibition of the SAPK/JNK pathway blocks the stimulatory effects of glutamine on fluid secretion by the Malpighian tubules of Rhodnius prolixus. | Journal of insect physiology 20031001 |
| The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. | The Journal of pharmacology and experimental therapeutics 20030901 |
| Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts. | European journal of endocrinology 20030901 |
| Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. | Archives of pharmacal research 20030901 |
| The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. | The EMBO journal 20030815 |
| SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. | Biochemical and biophysical research communications 20030808 |
| Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases. | American journal of physiology. Lung cellular and molecular physiology 20030801 |
| The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. | Carcinogenesis 20030801 |
| c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. | Molecular pharmacology 20030801 |
| Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-alpha in cultured human umbilical vein endothelial cells. | Cardiovascular research 20030801 |
| Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase. | Surgery 20030801 |
| The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity. | Chemistry & biology 20030801 |
| c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production. | Journal of immunology (Baltimore, Md. : 1950) 20030715 |
| c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. | The Journal of biological chemistry 20030711 |
| JNK phosphorylates paxillin and regulates cell migration. | Nature 20030710 |
| Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation. | The Journal of biological chemistry 20030704 |
| Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells. | American journal of respiratory cell and molecular biology 20030701 |
| Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. | Genes & development 20030701 |
| The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression. | Neoplasia (New York, N.Y.) 20030701 |
| JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents. | The Journal of biological chemistry 20030620 |
| The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. | The Journal of biological chemistry 20030606 |
| C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. | American journal of respiratory cell and molecular biology 20030601 |
| Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. | Hepatology (Baltimore, Md.) 20030601 |
| Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. | The Journal of biological chemistry 20030516 |
| JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. | The Journal of biological chemistry 20030516 |
| Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. | Journal of immunology (Baltimore, Md. : 1950) 20030515 |
| Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK. | Cardiovascular drugs and therapy 20030501 |
| The specificities of protein kinase inhibitors: an update. | The Biochemical journal 20030401 |
| c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. | Hepatology (Baltimore, Md.) 20030401 |
| Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030401 |
| Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts. | The Journal of endocrinology 20030401 |
| Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. | Oncogene 20030327 |
| Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. | The Journal of biological chemistry 20030307 |
| Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. | Oncogene 20030306 |
| Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells. | Molecular and cellular endocrinology 20030227 |
| Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. | Blood 20030215 |
| Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells. | Molecular pharmacology 20030201 |
| Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. | Journal of neurochemistry 20030201 |
| Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task. | The European journal of neuroscience 20030201 |
| Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. | The Journal of biological chemistry 20030103 |
| A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro. | Neuroscience 20030101 |
| p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth. | Molecular cancer 20030101 |
| Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. | The Biochemical journal 20021115 |
| [Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide]. | Zhonghua yi xue za zhi 20021025 |
| c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. | Circulation research 20021004 |
| Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase. | Archives of biochemistry and biophysics 20020915 |
| An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. | Biochimica et biophysica acta 20020508 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts. | Journal of cellular biochemistry 20020101 |
| Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571. | Cancer biology & therapy 20020101 |
| Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes. | American journal of physiology. Cell physiology 20011201 |
| SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. | Proceedings of the National Academy of Sciences of the United States of America 20011120 |
| TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. | Hepatology (Baltimore, Md.) 20011101 |
| c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. | The Journal of clinical investigation 20010701 |
| Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. | Molecular endocrinology (Baltimore, Md.) |