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Bivalirudin

CAS No.:
128270-60-0
Catalog Number:
AG000XXZ
Molecular Formula:
C98H138N24O33
Molecular Weight:
2180.2853
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$125
- +
10mg
≥98%
1 week
United States
$160
- +
25mg
≥98%
1 week
United States
$296
- +
50mg
≥98%
1 week
United States
$465
- +
Product Description
Catalog Number:
AG000XXZ
Chemical Name:
Bivalirudin
CAS Number:
128270-60-0
Molecular Formula:
C98H138N24O33
Molecular Weight:
2180.2853
MDL Number:
MFCD08282793
IUPAC Name:
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[2-[[2-[[2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid
InChI:
InChI=1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1
InChI Key:
OIRCOABEOLEUMC-GEJPAHFPSA-N
SMILES:
CC[C@@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCC(=O)O)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N)CCCNC(=N)N)CC(=O)N)Cc1ccccc1)CCC(=O)O)CCC(=O)O)C
Properties
Complexity:
4950  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
16  
Defined Bond Stereocenter Count:
0
Exact Mass:
2179.989g/mol
Formal Charge:
0
Heavy Atom Count:
155  
Hydrogen Bond Acceptor Count:
35  
Hydrogen Bond Donor Count:
28  
Isotope Atom Count:
0
Molecular Weight:
2180.317g/mol
Monoisotopic Mass:
2178.986g/mol
Rotatable Bond Count:
67  
Topological Polar Surface Area:
902A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-7.1  
Literature
Title Journal
Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials 20121101
Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome. Expert opinion on drug metabolism & toxicology 20121101
Impact of in-hospital major bleeding on outcomes in acute coronary syndromes. Current opinion in cardiology 20121101
[New anticoagulants - direct thrombin inhibitors]. Therapeutische Umschau. Revue therapeutique 20121101
Bivalirudin has its own shelf in the cath lab, eventually. International journal of cardiology 20121018
Glycoprotein IIb-IIIa inhibitors. Cardiovascular therapeutics 20121001
Comparison of bolus only with bolus plus infusion of bivalirudin in patients undergoing elective percutaneous coronary intervention: a retrospective observational study. Journal of pharmacy practice 20121001
Acute ST-elevation myocardial infarction. Current opinion in critical care 20121001
Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful? American journal of clinical pathology 20121001
Bivalirudin versus heparin plus a glycoprotein IIb/IIIa inhibitor in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention after clopidogrel pretreatment: pooled analysis from the ACUITY and ISAR-REACT 4 trials. Circulation. Cardiovascular interventions 20121001
Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120915
Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair. Circulation research 20120914
Translational success stories: development of direct thrombin inhibitors. Circulation research 20120914
Outcomes of patients with prior coronary artery bypass grafting and acute coronary syndromes: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. JACC. Cardiovascular interventions 20120901
Association between periprocedural bleeding and long-term outcomes following percutaneous coronary intervention in older patients. JACC. Cardiovascular interventions 20120901
Safety and efficacy of bivalirudin with glycoprotein IIb/IIIa for high-risk percutaneous coronary intervention. Indian heart journal 20120901
Bivalirudin: the relevance in today's interventional practice. Indian heart journal 20120901
Comparison of safety and efficacy of bivalirudin versus unfractionated heparin in high-risk patients undergoing percutaneous coronary intervention (from the Anti-Thrombotic Strategy for Reduction of Myocardial Damage During Angioplasty-Bivalirudin vs Heparin study). The American journal of cardiology 20120815
Meta-analysis comparing bivalirudin versus heparin monotherapy on ischemic and bleeding outcomes after percutaneous coronary intervention. The American journal of cardiology 20120815
Controlled reperfusion with intravenous bivalirudin and intracoronary abciximab combination therapy in the porcine myocardial infarction model. Thrombosis research 20120801
Bivalirudin is inferior to heparin in preservation of intraoperative autologous blood. Thrombosis research 20120801
Bivalirudin versus unfractionated heparin in percutaneous coronary interventions of patients having received initial fondaparinux treatment: a propensity matched study. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120801
Platelet reactivity and percutaneous coronary intervention: another clue in the quest for the Holy Grail of tailored antithrombotic therapy? Journal of the American College of Cardiology 20120731
Prognostic value of a high on-clopidogrel treatment platelet reactivity in bivalirudin versus abciximab treated non-ST-segment elevation myocardial infarction patients. ISAR-REACT 4 (Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment-4) platelet substudy. Journal of the American College of Cardiology 20120731
GP IIb/IIIa inhibitors for STEMI: still the gold standard or an old survivor? Current vascular pharmacology 20120701
In the bivalirudin era, are we still looking for a potent antiplatelet agent? Current vascular pharmacology 20120701
What is the optimal antithrombotic strategy in primary percutaneous coronary intervention? Current opinion in cardiology 20120701
Understanding the cost-effectiveness of bivalirudin. Heart (British Cardiac Society) 20120701
Quantification and impact of untreated coronary artery disease after percutaneous coronary intervention: the residual SYNTAX (Synergy Between PCI with Taxus and Cardiac Surgery) score. Journal of the American College of Cardiology 20120612
New targets for anticoagulation and future perspectives. Current drug discovery technologies 20120601
New parenteral anticoagulants: focus on factor Xa and thrombin inhibitors. Current drug discovery technologies 20120601
Discovery of anticoagulant drugs: a historical perspective. Current drug discovery technologies 20120601
Effect of bivalirudin compared with unfractionated heparin plus abciximab on infarct size and myocardial recovery after primary percutaneous coronary intervention: the horizons-AMI CMRI substudy. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120601
Comparative effectiveness analysis of anticoagulant strategies in a large observational database of percutaneous coronary interventions. Journal of interventional cardiology 20120601
The effect of differing pharmacologic strategies on infarct size in primary PCI--more confirmatory data for bivalirudin. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120601
Alternative anticoagulation during cardiovascular procedures in pediatric patients with heparin-induced thrombocytopenia. The journal of extra-corporeal technology 20120601
Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry. Journal of the American College of Cardiology 20120522
Clinical outcomes following stent thrombosis occurring in-hospital versus out-of-hospital: results from the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial. Journal of the American College of Cardiology 20120515
Cardiac surgery and heparin induced thrombocytopaenia (HIT): a case report and short review. Heart, lung & circulation 20120501
Advances in laboratory testing for thrombophilia. American journal of hematology 20120501
Feasibility and safety of transradial approach and bivalirudin treatment in elderly patients undergoing early invasive strategy for ACS: 'The OLDER Research Project' preliminary study. Journal of cardiovascular medicine (Hagerstown, Md.) 20120501
Direct thrombin inhibitors in cardiovascular disease. Nature reviews. Cardiology 20120501
Clinical safety of bivalirudin in patients undergoing carotid stenting. The Journal of invasive cardiology 20120501
Comparison of percutaneous coronary intervention safety before and during the establishment of a transradial program at a teaching hospital. The American journal of cardiology 20120415
Impact of anticoagulation on ionic and nonionic contrast media effect on thrombogenesis and fibrinolysis: The PEPCIT study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20120401
Bivalirudin used as alternative anticoagulant in carotid artery stenting: a single center observational study. Journal of interventional cardiology 20120401
Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia. Journal of thrombosis and thrombolysis 20120401
Cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor in the treatment of acute ST-segment elevation myocardial infarction. Heart (British Cardiac Society) 20120401
Prognostic significance of elevated baseline troponin in patients with acute coronary syndromes and chronic kidney disease treated with different antithrombotic regimens: a substudy from the ACUITY trial. Circulation. Cardiovascular interventions 20120401
Cost effectiveness of anticoagulation in acute coronary syndromes. PharmacoEconomics 20120401
Bivalirudin for primary percutaneous coronary intervention in acute myocardial infarction: the HORIZONS-AMI trial. Expert review of cardiovascular therapy 20120401
Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention. Circulation 20120320
Bivalirudin in acute myocardial infarction: NICE guidance. Heart (British Cardiac Society) 20120301
The ECG as decision support in STEMI. Danish medical journal 20120301
The prognostic meaning of the full spectrum of aVR ST-segment changes in acute myocardial infarction. European heart journal 20120201
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 20120201
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 20120201
Glycoprotein IIb/IIIa inhibitors and bivalirudin in patients undergoing percutaneous coronary intervention. Minerva cardioangiologica 20120201
Acute stent thrombosis: technical complication or inadequate antithrombotic therapy? An optical coherence tomography study. JACC. Cardiovascular interventions 20120201
Heparin induced thrombocytopenia: case presentation and review. Journal of clinical medicine research 20120201
Prehospital treatment of patients with acute myocardial infarction with bivalirudin. The American journal of emergency medicine 20120101
Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guidelines as an indication for reperfusion therapy? European heart journal 20120101
Association between bleeding severity and long-term mortality in patients experiencing vascular complications after percutaneous coronary intervention. The American journal of cardiology 20120101
Safety of bivalirudin in patients with coronary artery disease. Expert opinion on drug safety 20120101
Incidence of bleeding in renally impaired patients receiving incorrectly dosed eptifibatide or bivalirudin while undergoing percutaneous coronary intervention. The Annals of pharmacotherapy 20120101
Recent advances in epidural analgesia. Anesthesiology research and practice 20120101
Dabigatran use in a postoperative coronary artery bypass surgery patient with nonvalvular atrial fibrillation and heparin-PF4 antibodies. The Annals of pharmacotherapy 20120101
Bivalirudin therapy is associated with improved clinical and economic outcomes in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention: results from an observational database. Circulation. Cardiovascular quality and outcomes 20120101
Efficacy and safety of enoxaparin versus unfractionated heparin during percutaneous coronary intervention: systematic review and meta-analysis. BMJ (Clinical research ed.) 20120101
Challenges encountered with argatroban anticoagulation during cardiopulmonary bypass. Journal of anaesthesiology, clinical pharmacology 20120101
Increased atherothrombotic burden in patients with diabetes mellitus and acute coronary syndrome: a review of antiplatelet therapy. Cardiology research and practice 20120101
Probing high affinity sequences of DNA aptamer against VEGF165. PloS one 20120101
Comparison of bivalirudin dosing strategies using total, adjusted, and ideal body weights in obese patients with heparin-induced thrombocytopenia. Pharmacotherapy 20120101
Oral antiplatelet therapy for atherothrombotic disease: overview of current and emerging treatment options. Vascular health and risk management 20120101
Translatability scoring in drug development: eight case studies. Journal of translational medicine 20120101
Outcome of the HORIZONS-AMI trial: bivalirudin enhances long-term survival in patients with ST-elevation myocardial infarction undergoing angioplasty. Vascular health and risk management 20120101
Stroke Prevention in Atrial Fibrillation: Where are We Now? Clinical Medicine Insights. Cardiology 20120101
Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response. Clinical pharmacology : advances and applications 20120101
The avantgarde carbostent in patients scheduled for undelayable noncardiac surgery. Thrombosis 20120101
Thrombus aspiration during primary percutaneous coronary intervention is associated with reduced myocardial edema, hemorrhage, microvascular obstruction and left ventricular remodeling. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20120101
Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors. PloS one 20120101
Current status of new anticoagulants in the management of venous thromboembolism. Advances in hematology 20120101
Hitting back HIT. Annals of cardiac anaesthesia 20120101
Distinct effects of unfractionated heparin versus bivalirudin on circulating angiogenic peptides. PloS one 20120101
Pre-emptive use of bivalirudin for emergent off-pump coronary artery bypass surgery in a suspected case of heparin-induced thrombocytopenia. Indian journal of anaesthesia 20120101
Safety and 1-year revascularization outcome of SilverHawk atherectomy in treating in-stent restenosis of femoropopliteal arteries: a retrospective review from a single center. Cardiovascular revascularization medicine : including molecular interventions 20120101
Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease. Thrombosis 20120101
Stent thrombosis: incidence, predictors and new technologies. Thrombosis 20120101
Dabigatran for stroke prevention in nonvalvular atrial fibrillation: answers to challenging 'real-world' questions. Thrombosis 20120101
Emerging anticoagulants. Current medicinal chemistry 20120101
Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity. PloS one 20120101
Simultaneous transradial coronary and renal in stent restenosis treatment in diabetic patient with NSTEMI complicated by hypertensive emergency. Medical archives (Sarajevo, Bosnia and Herzegovina) 20120101
Heparin-induced thrombocytopenia in the pediatric population: a review of current literature. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20120101
Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo. Blood 20111215
Bivalirudin for patients with ST-elevation myocardial infarction. Lancet (London, England) 20111203
Old and new antithrombotic drugs in neonates and infants. Seminars in fetal & neonatal medicine 20111201
Loading solution prevents activation damage of human platelets before lyophilization. Cryobiology 20111201
Prasugrel and bivalirudin for primary angioplasty: early results on stent thrombosis and bleeding. International journal of cardiology 20111201
[Mortality of myocardial infarction]. Annales de cardiologie et d'angeiologie 20111201
Radial access in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty in acute myocardial infarction: the HORIZONS-AMI trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20111201
Almanac 2011: acute coronary syndromes. The national society journals present selected research that has driven recent advances in clinical cardiology. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20111201
Abciximab and heparin versus bivalirudin for non-ST-elevation myocardial infarction. The New England journal of medicine 20111124
Safety and efficacy of antiplatelet and antithrombotic therapy in acute coronary syndrome patients with chronic kidney disease. Journal of the American College of Cardiology 20111122
Impact of smoking on outcomes of patients with ST-segment elevation myocardial infarction (from the HORIZONS-AMI Trial). The American journal of cardiology 20111115
Comparison of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in patients undergoing an invasive strategy: a meta-analysis of randomized clinical trials. International journal of cardiology 20111103
Initial experience with an institutional bridging protocol for patients with recent coronary stent implantation requiring discontinuation of dual antiplatelet therapy resulting from urgent surgery. American journal of therapeutics 20111101
Novel techniques in the use of bivalirudin for cardiopulmonary bypass anticoagulation in a child with heparin-induced thrombocytopenia. Perfusion 20111101
Effect of prolonged Bivalirudin infusion on ST-segment resolution following primary percutaneous coronary intervention (from the PROBI VIRI 2 study). The American journal of cardiology 20111101
[Proteins influencing the blood coagulation]. Therapeutische Umschau. Revue therapeutique 20111101
Direct thrombin inhibitors. British journal of clinical pharmacology 20111001
Outcomes of coronary arterial perforations during percutaneous coronary intervention with bivalirudin anticoagulation. The American journal of cardiology 20111001
Bivalirudin dosing adjustments for reduced renal function with or without hemodialysis in the management of heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20111001
Bleeding risk comparing targeted low-dose heparin with bivalirudin in patients undergoing percutaneous coronary intervention: results from a propensity score-matched analysis of the Evaluation of Drug-Eluting Stents and Ischemic Events (EVENT) registry. Circulation. Cardiovascular interventions 20111001
Incidence and predictors of heart failure following percutaneous coronary intervention in ST-segment elevation myocardial infarction: the HORIZONS-AMI trial. American heart journal 20111001
Acute coronary syndromes: Antithrombotics in ACS--moving beyond unfractionated heparin. Nature reviews. Cardiology 20110927
Unfractionated heparin administration in patients treated with bivalirudin during primary percutaneous coronary intervention is associated lower mortality and target lesion thrombosis: a report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Heart (British Cardiac Society) 20110901
Optimal antithrombotic treatment during primary percutaneous coronary intervention? Heart (British Cardiac Society) 20110901
Recent advances in heparin-induced thrombocytopenia. Current opinion in hematology 20110901
Bivalirudin for anticoagulation during hypothermic cardiopulmonary bypass and recombinant factor VIIa for iatrogenic coagulopathy. The Annals of pharmacotherapy 20110901
The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction. American heart journal 20110901
Endoluminal treatment of peripheral chronic total occlusions using the Crosser® recanalization catheter. The Journal of invasive cardiology 20110901
Correlation of bivalirudin dose with creatinine clearance during treatment of heparin-induced thrombocytopenia. Pharmacotherapy 20110901
Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarction and chronic kidney disease undergoing percutaneous coronary intervention. JACC. Cardiovascular interventions 20110901
Long-term impact of chronic kidney disease in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. JACC. Cardiovascular interventions 20110901
Interventional cardiology: Antithrombotic drug and stent choices in primary PCI. Nature reviews. Cardiology 20110809
Safety and tolerability of high-intensity anticoagulation with bivalirudin during neuroendovascular procedures. Neurocritical care 20110801
Integrilin in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Journal of interventional cardiology 20110801
Massive thrombosis of venous aortic coronary bypass graft treated with bivalirudin and combined technique of thrombectomy and filter distal protection. Journal of cardiovascular medicine (Hagerstown, Md.) 20110801
How serious a problem is bleeding in patients with acute coronary syndromes? Current cardiology reports 20110801
Is a metallic microcoil really a permanent embolic agent for the management of distal guidewire-induced coronary artery perforation? Korean circulation journal 20110801
Heparin-induced thrombocytopenia. Clinical advances in hematology & oncology : H&O 20110801
Statin effect on thrombin inhibitor effectiveness during percutaneous coronary intervention: a post-hoc analysis from the ISAR-REACT 3 trial. Clinical research in cardiology : official journal of the German Cardiac Society 20110701
An assay to monitor bivalirudin levels on cardiopulmonary bypass. The Annals of thoracic surgery 20110701
Impact of diabetes mellitus on the safety and effectiveness of bivalirudin in patients with acute myocardial infarction undergoing primary angioplasty: analysis from the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) trial. JACC. Cardiovascular interventions 20110701
Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial. Lancet (London, England) 20110625
Effect of clopidogrel pretreatment on ischemic complications of percutaneous coronary intervention among bivalirudin-treated patients (from the EVENT registry). The American journal of cardiology 20110615
Prognostic value of the SYNTAX score in patients with acute coronary syndromes undergoing percutaneous coronary intervention: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) trial. Journal of the American College of Cardiology 20110614
Effect of switching antithrombin agents for primary angioplasty in acute myocardial infarction: the HORIZONS-SWITCH analysis. Journal of the American College of Cardiology 20110607
Clinical applications of bivalirudin in the cardiac catheterization laboratory. Journal of cardiovascular pharmacology and therapeutics 20110601
Comparison of MAX-ACT and K-ACT values when using bivalirudin anticoagulation during minimally invasive hybrid off-pump coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 20110601
Use of prolonged bivalirudin infusions following percutaneous coronary intervention. Cardiovascular drugs and therapy 20110601
Intravascular ultrasound findings of early stent thrombosis after primary percutaneous intervention in acute myocardial infarction: a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) substudy. Circulation. Cardiovascular interventions 20110601
A randomized two-by-two comparison of high-dose bolus tirofiban versus abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary revascularization and stent placement: the tirofiban evaluation of novel dosing versus abciximab with clopidogrel and inhibition of thrombin (TENACITY) study trial. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110601
Looking back into the future: desirudin in acute coronary syndromes and coronary stenting. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20110601
Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials. JACC. Cardiovascular interventions 20110601
Bivalirudin in contemporary percutaneous coronary intervention for non-ST-segment elevation acute coronary syndromes: what is the current role of platelet glycoprotein IIb/IIIa receptor inhibitor agents? Critical pathways in cardiology 20110601
Upstream treatment of acute coronary syndrome in the ED. The American journal of emergency medicine 20110501
Two hour bivalirudin infusion after PCI for ST elevation myocardial infarction. Journal of thrombosis and thrombolysis 20110501
[Bivalirudin as an anticoagulant during percutaneous coronary interventions in acute coronary syndromes: strengths and doubts]. Revista espanola de cardiologia 20110501
The relationship between attenuated plaque identified by intravascular ultrasound and no-reflow after stenting in acute myocardial infarction: the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. JACC. Cardiovascular interventions 20110501
Future anticoagulants in interventional cardiology: anti-IXa and anti-Xa agents in percutaneous coronary intervention. Future cardiology 20110501
Threshold haemoglobin levels and the prognosis of stable coronary disease: two new cohorts and a systematic review and meta-analysis. PLoS medicine 20110501
Frequency and predictors of stent thrombosis after percutaneous coronary intervention in acute myocardial infarction. Circulation 20110426
Update in hematology: heparin-induced thrombocytopenia and bivalirudin. Journal of cardiothoracic and vascular anesthesia 20110401
Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circulation. Cardiovascular interventions 20110401
Bivalirudin: a pharmacoeconomic profile of its use in patients with acute coronary syndromes. PharmacoEconomics 20110401
Pediatric catheterization laboratory anticoagulation with bivalirudin. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110401
Practical viewpoints on the diagnosis and management of heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20110401
Glycoprotein IIb/IIIa inhibitors: do they still have a role? Journal of the American College of Cardiology 20110308
The time dependence of antithrombin initiation in patients with non-ST-segment elevation acute coronary syndromes: subgroup analysis from the ACUITY trial. Annals of emergency medicine 20110301
Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110301
High-shear- and-thrombin-inducible platelet adhesion and aggregation in patients undergoing percutaneous coronary intervention. Effects of unfractionated heparin versus bivalirudin. Thrombosis and haemostasis 20110301
Adjunctive pharmacologic therapy in percutaneous coronary intervention: part II anticoagulant therapy. Coronary artery disease 20110301
Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia. American journal of hematology 20110301
Use of low-dose heparin with bivalirudin for ad-hoc transradial coronary interventions: experience from a single center. The Journal of invasive cardiology 20110301
Bivalirudin and transradial access--the end of the bleeding era for catheterization procedures? The Journal of invasive cardiology 20110301
Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. American heart journal 20110301
Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation: a case report and review of the literature. The journal of extra-corporeal technology 20110301
Regarding changing outcomes and treatment strategies for wire-induced coronary perforations in the era of bivalirudin use. A word of caution concerning the use of bivalirudin during coronary intervention for lesions at high risk for perforation. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20110215
Clopidogrel pretreatment in PCI: absolute requirement or obsolete myth? International journal of cardiology 20110203
New parenteral anticoagulants in development. Therapeutic advances in cardiovascular disease 20110201
New anticoagulants in children: a review of recent studies and a look to the future. Thrombosis research 20110201
New anticoagulant agents in acute coronary syndromes. Heart (British Cardiac Society) 20110201
Antithrombotic therapy in ST-segment elevation myocardial infarction. Expert opinion on pharmacotherapy 20110201
[Direct inhibitors of thrombin, hirudin, bivalirudin, and dabigatran etexilate]. Journal des maladies vasculaires 20110201
Cardiva Catalyst II vascular access management device in percutaneous diagnostic and interventional procedures with same-day discharge (Catalyst II trial). Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20110201
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. American heart journal 20110201
Incidence, prognostic impact, and influence of antithrombotic therapy on access and nonaccess site bleeding in percutaneous coronary intervention. JACC. Cardiovascular interventions 20110201
Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children. Wiener medizinische Wochenschrift (1946) 20110201
Studies on the effects of heparin products on pregnancy-associated plasma protein A. Clinica chimica acta; international journal of clinical chemistry 20110130
Combined blockade of thrombin anion binding exosite-1 and PAR4 produces synergistic antiplatelet effect in human platelets. Thrombosis and haemostasis 20110101
A randomized pilot trial for aggressive therapeutic approaches in aspirin-resistant patients undergoing percutaneous coronary intervention. The Journal of invasive cardiology 20110101
Platelet resistance - much known and much more unknown. The Journal of invasive cardiology 20110101
Cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor in the treatment of non-ST-segment elevation acute coronary syndromes. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110101
Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium. European heart journal 20110101
Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance--the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy. BMC medicine 20110101
A network-based multi-target computational estimation scheme for anticoagulant activities of compounds. PloS one 20110101
Heparin-induced thrombocytopenia in the ICU: an overview. Critical care (London, England) 20110101
Lepirudin as an alternative to 'heparin allergy' during cardiopulmonary bypass. Journal of cardiothoracic surgery 20110101
Heparin-induced thrombocytopenia. Journal of emergencies, trauma, and shock 20110101
Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial. BMJ (Clinical research ed.) 20110101
Dealing with thrombocytopenia during anticoagulation with heparins for active venous thromboembolism: a play-it-safe practical approach. Therapeutics and clinical risk management 20110101
Oral antiplatelet therapy in diabetes mellitus and the role of prasugrel: an overview. Vascular health and risk management 20110101
Implications of bleeding in acute coronary syndrome and percutaneous coronary intervention. Vascular health and risk management 20110101
Tissue factor, blood coagulation, and beyond: an overview. International journal of inflammation 20110101
An optimized method to assess in vivo efficacy of antithrombotic drugs using optical coherence tomography and a modified Doppler flow system. Journal of pharmacological and toxicological methods 20110101
Role of factor xa inhibitors in cancer-associated thrombosis: any new data? Advances in hematology 20110101
Emerging therapies for acute coronary syndromes. Frontiers in pharmacology 20110101
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors. PloS one 20110101
Bivalirudin-based versus conventional heparin anticoagulation for postcardiotomy extracorporeal membrane oxygenation. Critical care (London, England) 20110101
Pharmacokinetics, pharmacodynamics, tolerability and safety of single doses of bivalirudin in healthy chinese subjects. Biological & pharmaceutical bulletin 20110101
New derivative of staphylokinase SAK-RGD-K2-Hirul exerts thrombolytic effects in the arterial thrombosis model in rats. Pharmacological reports : PR 20110101
Modeling the effects of bivalirudin in cardiac surgical patients. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20110101
Signal protein-derived peptides as functional probes and regulators of intracellular signaling. Journal of amino acids 20110101
Bivalirudin use in an infant with persistent clotting on unfractionated heparin. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20110101
Heparin versus bivalirudin for carotid artery stenting using proximal endovascular clamping for neuroprotection: results from a prospective randomized study. Journal of vascular surgery 20101201
[Evidence-based management of ST-segment elevation myocardial infarction (STEMI). Latest guidelines of the European Society of Cardiology (ESC) 2010]. Herz 20101201
Bivalirudin: a review of the pharmacology and clinical application. Expert review of cardiovascular therapy 20101201
Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia. Pharmacotherapy 20101201
[Comments on the 2010 guidelines on cardiopulmonary resuscitation of the European Resuscitation Council]. Der Anaesthesist 20101201
The evolving role of glycoprotein IIb/IIIa inhibitors in the setting of percutaneous coronary intervention strategies to minimize bleeding risk and optimize outcomes. JACC. Cardiovascular interventions 20101201
Comparison of bivalirudin versus heparin on radial artery occlusion after transradial catheterization. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101101
Safety of immediate reversal of anticoagulation by protamine to reduce bleeding complications after infarct artery stenting for acute myocardial infarction and adjunctive abciximab therapy. Journal of thrombosis and thrombolysis 20101101
M-AAA-thrombin: potent anticoagulant and antiplatelet thrombin derivative with differential affinity for factor VIII and PAR1. Thrombosis research 20101101
Oral thrombostatin FM19 inhibits prostate cancer. Thrombosis and haemostasis 20101101
Bivalirudin versus unfractionated heparin for prevention of hemofilter occlusion during continuous renal replacement therapy. Pharmacotherapy 20101101
Radial artery occlusion- a limitation of transradial catheterization. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101101
Impact of transfer for primary percutaneous coronary intervention on survival and clinical outcomes (from the HORIZONS-AMI Trial). The American journal of cardiology 20101101
Validation of long-term benefits of bivalirudin versus unfractionated heparin in routine clinical practice after percutaneous coronary intervention. The American journal of cardiology 20101101
Economic impact of switching to bivalirudin for a primary percutaneous coronary intervention in a US hospital. Hospital practice (1995) 20101101
Use of anticoagulant agents and risk of bleeding among patients admitted with myocardial infarction: a report from the NCDR ACTION Registry--GWTG (National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry--Get With the Guidelines). JACC. Cardiovascular interventions 20101101
The HIT treatment in a cardiac surgery patient. International journal of cardiology 20101029
Correlates and consequences of gastrointestinal bleeding complicating percutaneous coronary intervention. The American journal of cardiology 20101015
Cerebrospinal fluid drainage with bivalirudin and rFactor VIIa for thoracic aortic aneurysm surgery using left atrial-femoral artery bypass. Journal of cardiothoracic and vascular anesthesia 20101001
Bivalirudin in patients with coronary artery disease. Cardiovascular & hematological agents in medicinal chemistry 20101001
ISAR-REACT 3A: a study of reduced dose of unfractionated heparin in biomarker negative patients undergoing percutaneous coronary intervention. European heart journal 20101001
Comparison of Bivalirudin versus Bivalirudin plus glycoprotein IIb/IIIa inhibitor versus heparin plus glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes having percutaneous intervention for narrowed saphenous vein aorto-coronary grafts (the ACUITY trial investigators). The American journal of cardiology 20101001
Efficacy and safety of bivalirudin in patients receiving clopidogrel therapy after diagnostic angiography for percutaneous coronary intervention in acute coronary syndromes. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101001
It is standard practice, but is it really best practice or clinical biocreep? Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20101001
Rapid adoption of drug-eluting stents: clinical practices and outcomes from the early drug-eluting stent era. American heart journal 20101001
Transradial approach for coronary angiography and interventions: results of the first international transradial practice survey. JACC. Cardiovascular interventions 20101001
Surgical versus percutaneous revascularization for multivessel disease in patients with acute coronary syndromes: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. JACC. Cardiovascular interventions 20101001
Frequency and predictors of drug-eluting stent use in saphenous vein bypass graft percutaneous coronary interventions: a report from the American College of Cardiology National Cardiovascular Data CathPCI registry. JACC. Cardiovascular interventions 20101001
Successful percutaneous coronary intervention for acute coronary syndrome in a patient with severe hemophilia a. Korean circulation journal 20101001
Letter by De Servi and Navarese regarding article, 'Prognostic modeling of individual patient risk and mortality impact of ischemic and hemorrhagic complications: assessment from the Acute Catheterization and Urgent Intervention Triage Strategy trial'. Circulation 20100921
Treatment options in heparin-induced thrombocytopenia. Current opinion in hematology 20100901
Case report: a thrombus in the venous reservoir while using bivalirudin in a patient with heparin-induced thrombocytopenia undergoing heart transplantation. Anesthesia and analgesia 20100901
[Heparin-induced thrombocytopenia]. Der Internist 20100901
Warfarin-induced penile necrosis in a patient with heparin-induced thrombocytopenia. Journal of Korean medical science 20100901
Bivalirudin use during radiofrequency catheter ablation procedures in two patients with a history of heparin-induced thrombocytopenia. Pharmacotherapy 20100901
Use of bivalirudin for heparin-induced thrombocytopaenia after thrombolysis in massive pulmonary embolism: a case report. International journal of emergency medicine 20100901
Prognostic value of lead V1 ST elevation during acute inferior myocardial infarction. Circulation 20100803
Balancing the benefits and risks of antiplatelet agents in patients with non-ST-segment elevated acute coronary syndromes and undergoing percutaneous coronary intervention. Journal of thrombosis and thrombolysis 20100801
A pilot, prospective evaluation of a direct thrombin inhibitor, bivalirudin (Angiomax), in patients undergoing lower extremity bypass. Journal of vascular surgery 20100801
aVR ST elevation: an important but neglected sign in ST elevation acute myocardial infarction. European heart journal 20100801
The use of bivalirudin for cardiopulmonary bypass anticoagulation in pediatric heparin-induced thrombocytopenia patients. Artificial organs 20100801
Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. The American journal of cardiology 20100801
Case report: a 55-year-old woman with chest pain upon arrival to the emergency department. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801
Pharmacologic therapy for non ST-segment elevation acute coronary syndromes: focus on antithrombotic therapy. Cardiovascular drugs and therapy 20100801
Impact of bivalirudin therapy in high-risk patients with acute myocardial infarction: 1-year results from the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) trial. JACC. Cardiovascular interventions 20100801
Bivalirudin in acute myocardial infarction: 'primum non nocere': the eternal dilemma: balancing risks and benefits in high-risk patients. JACC. Cardiovascular interventions 20100801
Retroperitoneal hematoma after percutaneous coronary intervention: prevalence, risk factors, management, outcomes, and predictors of mortality: a report from the BMC2 (Blue Cross Blue Shield of Michigan Cardiovascular Consortium) registry. JACC. Cardiovascular interventions 20100801
Cost-effectiveness of targeting patients undergoing percutaneous coronary intervention for therapy with bivalirudin versus heparin monotherapy according to predicted risk of bleeding. Circulation. Cardiovascular quality and outcomes 20100701
A comment on laboratory monitoring of new anticoagulants. American journal of hematology 20100701
Management of protamine allergy with bivalirudin during coronary artery revascularization. The Annals of thoracic surgery 20100701
Outcomes research: the next generation. Circulation. Cardiovascular quality and outcomes 20100701
A risk score to predict bleeding in patients with acute coronary syndromes. Journal of the American College of Cardiology 20100608
Association between use of bleeding avoidance strategies and risk of periprocedural bleeding among patients undergoing percutaneous coronary intervention. JAMA 20100602
Use of platelet glycoprotein IIb/IIIa inhibitors in diabetics undergoing PCI for non-ST-segment elevation acute coronary syndromes: impact of clinical status and procedural characteristics. Clinical research in cardiology : official journal of the German Cardiac Society 20100601
Anesthetic concerns for patients with coagulopathy. Current opinion in anaesthesiology 20100601
Bivalirudin during percutaneous coronary interventions in patients with ST segment elevation myocardial infarction. Acute cardiac care 20100601
The impact of bivalirudin on percutaneous coronary intervention-related bleeding. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20100601
Unexplained international differences in clinical outcomes after acute myocardial infarction and fibrinolytic therapy: lessons from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial. American heart journal 20100601
Body mass index and bleeding complications after percutaneous coronary intervention: does bivalirudin make a difference? American heart journal 20100601
Antithrombotic strategy in non-ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry. JACC. Cardiovascular interventions 20100601
Why we do what we do? Making sense of antithrombotic therapy in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. JACC. Cardiovascular interventions 20100601
Safety and efficacy of bivalirudin for percutaneous coronary intervention with rotational atherectomy. Journal of interventional cardiology 20100601
Bivalirudin for mechanical rotational atherectomy: the quest for better outcomes. Journal of interventional cardiology 20100601
Impact of anemia on clinical outcomes of patients with ST-segment elevation myocardial infarction in relation to gender and adjunctive antithrombotic therapy (from the HORIZONS-AMI trial). The American journal of cardiology 20100515
Bivalirudin: in patients with ST-segment elevation myocardial infarction. Drugs 20100507
Development and validation of a LC-MS/MS method for determination of bivalirudin in human plasma: Application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20100501
Decline in platelet count in patients treated by percutaneous coronary intervention: definition, incidence, prognostic importance, and predictive factors. European heart journal 20100501
The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis. Thrombosis and haemostasis 20100501
Comparison of bivalirudin and unfractionated heparin plus protamine in patients with coronary heart disease undergoing percutaneous coronary intervention (from the Antithrombotic Regimens aNd Outcome [ARNO] trial). The American journal of cardiology 20100415
Frequency and safety of switching antithrombin therapy at a regional PCI center. Journal of thrombosis and thrombolysis 20100401
[Clinical and economical evaluation of bivalirudin during percutaneous coronary interventions]. Annales de cardiologie et d'angeiologie 20100401
Antithrombotic drugs in coronary artery disease: risk benefit ratio and bleeding. Journal of thrombosis and haemostasis : JTH 20100401
Recombinant factor VIIa to manage major bleeding from newer parenteral anticoagulants. The Annals of pharmacotherapy 20100401
Outcomes of Patients with coronary artery perforation complicating percutaneous coronary intervention and correlations with the type of adjunctive antithrombotic therapy: pooled analysis from REPLACE-2, ACUITY, and HORIZONS-AMI trials. Heparin only should be considered for lesions at high risk for perforation. Journal of interventional cardiology 20100401
Practical strategies for the management of anticoagulation therapy: unsolved issues in the cardiac catheterization laboratory. Cardiovascular drugs and therapy 20100401
Safety and effectiveness of bivalirudin in routine care of patients undergoing percutaneous coronary intervention. European heart journal 20100301
Laboratory monitoring of new anticoagulants. American journal of hematology 20100301
Which antithrombotic to use during PCI? European heart journal 20100301
Bivalirudin vs. unfractionated heparin during percutaneous coronary interventions in patients with stable and unstable angina pectoris: 1-year results of the ISAR-REACT 3 trial. European heart journal 20100301
Efficacy and safety of bivalirudin in patients with diabetes mellitus undergoing percutaneous coronary intervention in current clinical practice. The Journal of invasive cardiology 20100301
Anticoagulation during percutaneous coronary intervention in diabetics--is simpler always better? The Journal of invasive cardiology 20100301
Heparin-induced thrombocytopenia. Seminars in cardiothoracic and vascular anesthesia 20100301
Predictors of outcomes in medically treated patients with acute coronary syndromes after angiographic triage: an Acute Catheterization And Urgent Intervention Triage Strategy (ACUITY) substudy. Circulation 20100223
Treating non-ST-segment elevation acute coronary syndromes: if you aren't sure, at least do no harm. Circulation 20100223
Carotid stenting and bivalirudin with and without vascular closure: 3-year analysis of procedural outcomes. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20100215
Heparin-induced thrombocytopenia and cardiac surgery. Current opinion in anaesthesiology 20100201
Antiplatelet and anticoagulant therapies in acute coronary syndromes. Cardiovascular drugs and therapy 20100201
Safety and in-hospital outcomes of bivalirudin use in dialysis patients undergoing percutaneous coronary intervention. The American journal of cardiology 20100201
Impact of femoral vascular closure devices and antithrombotic therapy on access site bleeding in acute coronary syndromes: The Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. Circulation. Cardiovascular interventions 20100201
Anticoagulant therapy for percutaneous coronary intervention. Circulation. Cardiovascular interventions 20100201
In-hospital safety and effectiveness of bivalirudin in percutaneous peripheral interventions: data from a real-world registry. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20100201
Commentary: bivalirudin is a safe and effective anticoagulant in the percutaneous treatment of complex infrainguinal disease. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20100201
HORIZONS-AMI. Lancet (London, England) 20100130
Bleeding after percutaneous coronary intervention with Bivalirudin or unfractionated Heparin and one-year mortality. The American journal of cardiology 20100115
Prognostic modeling of individual patient risk and mortality impact of ischemic and hemorrhagic complications: assessment from the Acute Catheterization and Urgent Intervention Triage Strategy trial. Circulation 20100105
Failed pericardiocentesis for acute cardiac tamponade: two cases associated with bivalirudin administration during PCI. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20100101
Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. European heart journal 20100101
Heart transplantation using bivalirudin as anticoagulant. Interactive cardiovascular and thoracic surgery 20100101
Bivalirudin: alternative anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia. Recent patents on cardiovascular drug discovery 20100101
Effect of hirulog-like peptide on balloon catheter injury-induced neointimal formation in femoral arteries of minipigs and relationship with inflammatory mediators. Journal of vascular research 20100101
Platelet thrombin receptor antagonism and atherothrombosis. European heart journal 20100101
A poly-N-acetyl glucosamine hemostatic dressing for femoral artery access site hemostasis after percutaneous coronary intervention: a pilot study. The Journal of invasive cardiology 20100101
A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: design and statistical methods of the PERSEUS clinical program. Trials 20100101
Improving the management of non-ST elevation acute coronary syndromes: systematic evaluation of a quality improvement programme European QUality Improvement Programme for Acute Coronary Syndrome: the EQUIP-ACS project protocol and design. Trials 20100101
In-stent thrombosis after 68 months of implantation inspite of continuous dual antiplatelet therapy: a case report. Cases journal 20100101
Antithrombotic therapy in patients with coronary artery disease and with type 2 diabetes mellitus. Wiener medizinische Wochenschrift (1946) 20100101
Safety and efficacy of abciximab as an adjunct to percutaneous coronary intervention. Vascular health and risk management 20100101
Fondaparinux and acute coronary syndromes: update on the OASIS 5-6 studies. Vascular health and risk management 20100101
Heparin-induced thrombocytopenia: a practical review. Reviews in cardiovascular medicine 20100101
New options with dabigatran etexilate in anticoagulant therapy. Vascular health and risk management 20100101
Actual Role of Platelet Glycoprotein IIb/IIIa Receptor Inhibitors as Adjunctive Pharmacological Therapy to Primary Angioplasty in Acute Myocardial Infarction: In the Light of Recent Randomized Trials and Observational Studies with Bivalirudin. The open cardiovascular medicine journal 20100101
Antithrombotic strategies in patients undergoing percutaneous coronary intervention for acute coronary syndrome. Drug design, development and therapy 20100101
Argatroban in the management of heparin-induced thrombocytopenia. Vascular health and risk management 20100101
GPIIb/IIIa Receptor Antagonism Using Small Molecules Provides no Additive Long-Term Protection after Percutaneous Coronary Intervention as Compared to Clopidogrel Plus Aspirin. The open cardiovascular medicine journal 20100101
Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice. F1000 medicine reports 20100101
Antiphospholipid syndrome; its implication in cardiovascular diseases: a review. Journal of cardiothoracic surgery 20100101
Bivalirudin: a review of pharmacology and therapeutic use. Connecticut medicine 20100101
Transradial vs femoral percutaneous coronary intervention for left main disease in octogenarians. Indian heart journal 20100101
Our technique for transradial coronary angiography and interventions. Indian heart journal 20100101
Profound thrombocytopenia after primary exposure to eptifibatide. Drug, healthcare and patient safety 20100101
The Potential Value of Near Patient Platelet Function Testing in PCI: Randomised Comparison of 600 mg versus 900 mg Clopidogrel Loading Doses. Thrombosis 20100101
Emerging antiplatelet agents, differential pharmacology, and clinical utility. Journal of blood medicine 20100101
Oral antiplatelet therapy for acute and chronic management of NSTE ACS: residual ischemic risk and opportunities for improvement. Cardiovascular drugs and therapy 20091201
Avoiding intelligence failures in the cardiac catheterization laboratory: Strategies for the safe and rational use of dalteparin or enoxaparin during percutaneous coronary intervention. The Journal of invasive cardiology 20091201
Changing outcomes and treatment strategies for wire induced coronary perforations in the era of bivalirudin use. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091101
Comparison of bivalirudin monotherapy versus unfractionated heparin plus tirofiban in patients with diabetes mellitus undergoing elective percutaneous coronary intervention. The American journal of cardiology 20091101
''They can always hurt you more'' bivalirudin and the dynamic balance between bleeding and clotting. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20091101
Risk profile and benefits from Gp IIb-IIIa inhibitors among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-regression analysis of randomized trials. European heart journal 20091101
Comparison of prolonged bivalirudin infusion versus intraprocedural in preventing myocardial damage after percutaneous coronary intervention in patients with angina pectoris. The American journal of cardiology 20091015
Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: results from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial. Journal of the American College of Cardiology 20091006
The changing horizon of acute coronary syndrome. Lancet (London, England) 20091003
Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial. Lancet (London, England) 20091003
Outcomes of patients with coronary artery perforation complicating percutaneous coronary intervention and correlations with the type of adjunctive antithrombotic therapy: pooled analysis from REPLACE-2, ACUITY, and HORIZONS-AMI trials. Journal of interventional cardiology 20091001
Significantly improved vascular complications among women undergoing percutaneous coronary intervention: a report from the Northern New England Percutaneous Coronary Intervention Registry. Circulation. Cardiovascular interventions 20091001
Gastrointestinal bleeding in patients with acute coronary syndromes: incidence, predictors, and clinical implications: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. Journal of the American College of Cardiology 20090929
Otamixaban in acute coronary syndromes. Lancet (London, England) 20090905
Noncompetitive inhibitor of thrombin. Chembiochem : a European journal of chemical biology 20090904
Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090901
Heparin induced thrombocytopenia and re-thrombosis associated with warfarin and fondaparinux in a child. Pediatric blood & cancer 20090901
Oldies but goodies. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090901
Bivalirudin as compared to unfractionated heparin among patients undergoing coronary angioplasty: A meta-analyis of randomised trials. Thrombosis and haemostasis 20090901
Patient satisfaction is comparable to early discharge versus overnight observation after elective percutaneous coronary intervention. The Journal of invasive cardiology 20090901
Comparison of safety and efficacy of bivalirudin versus unfractionated heparin in percutaneous peripheral intervention: a single-center experience. JACC. Cardiovascular interventions 20090901
[What's new on antithrombotics?]. Annales de cardiologie et d'angeiologie 20090801
A novel hirudin derivative characterized with anti-platelet aggregations and thrombin inhibition. Journal of thrombosis and thrombolysis 20090801
Regulation of PAR-1 in patients undergoing percutaneous coronary intervention: effects of unfractionated heparin and bivalirudin. European heart journal 20090801
Safety and efficacy of a prolonged bivalirudin infusion after urgent and complex percutaneous coronary interventions: a descriptive study. Coronary artery disease 20090801
Novel anticoagulants in clinical development: focus on factor Xa and direct thrombin inhibitors. Journal of cardiovascular medicine (Hagerstown, Md.) 20090801
[New anticoagulants for secondary haemostasis--anti IIa inhibitors]. Hamostaseologie 20090801
Safety and efficacy of bivalirudin in high-risk patients admitted through the emergency department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20090801
Impact of chronic kidney disease on early (30-day) and late (1-year) outcomes of patients with acute coronary syndromes treated with alternative antithrombotic treatment strategies: an ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) substudy. JACC. Cardiovascular interventions 20090801
Balancing potency of platelet inhibition with bleeding risk in the early treatment of acute coronary syndrome. The western journal of emergency medicine 20090801
A comparison of anticoagulation with bivalirudin and provisional GPIIb/IIIa inhibition with unfractionated heparin and mandatory GPIIb/IIIa inhibition during percutaneous coronary intervention in relation to platelet activation and the inhibition of coagulation. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090801
Prognostic significance of periprocedural versus spontaneously occurring myocardial infarction after percutaneous coronary intervention in patients with acute coronary syndromes: an analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. Journal of the American College of Cardiology 20090728
Intracoronary bivalirudin for no reflow reversal: a second chance to treat this disorder? Journal of thrombosis and thrombolysis 20090701
Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin. Journal of thrombosis and thrombolysis 20090701
New antithrombotic agents in acute coronary syndromes. Current opinion in cardiology 20090701
Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapy. The Annals of pharmacotherapy 20090701
Bivalirudin as an anticoagulant for simultaneous integrated coronary artery revascularization - a novel approach to an inherent concern. The Canadian journal of cardiology 20090701
Expert consensus on treatment strategies in non- ST-segment elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention--an evidence-based review of clinical trial results and treatment guidelines from an emergency medicine perspective: report on a roundtable discussion. The American journal of emergency medicine 20090701
Feasibility and safety of prehospital administration of bivalirudin in patients with ST-elevation myocardial infarction. The American journal of cardiology 20090615
Hotline sessions presented at the American College of Cardiology Congress 2009. Clinical research in cardiology : official journal of the German Cardiac Society 20090601
Direct thrombin inhibitors in patients with mechanical heart valves: ready for clinical trials? Thrombosis and haemostasis 20090601
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study. Thrombosis and haemostasis 20090601
Frequency and outcomes of provisional glycoprotein IIb/IIIa blockade in patients receiving bivalirudin during percutaneous coronary intervention. The Journal of invasive cardiology 20090601
Provisional use of glycoprotein IIb/IIIa inhibitors in the era of dual antiplatelet therapy--do 'bailouts' pay off? The Journal of invasive cardiology 20090601
Hospitals with and without percutaneous coronary intervention capability: considerations for treating acute coronary syndromes. The American journal of emergency medicine 20090601
Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management. Chest 20090601
Diabetes and acute coronary syndromes. Best practice & research. Clinical endocrinology & metabolism 20090601
Outcomes following pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery: the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. Journal of the American College of Cardiology 20090526
Lepirudin-induced thrombocytopenia following subcutaneous administration. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090501
Impact of gender and antithrombin strategy on early and late clinical outcomes in patients with non-ST-elevation acute coronary syndromes (from the ACUITY trial). The American journal of cardiology 20090501
Pharmacological and clinical profile of bivalirudin in the treatment of patients with acute coronary syndrome. Expert opinion on drug metabolism & toxicology 20090501
Choice of arterial access site and outcomes in patients with acute coronary syndromes managed with an early invasive strategy: the ACUITY trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20090501
Click-chemistry-conjugated oligo-angiomax in the two-dimensional DNA lattice and its interaction with thrombin. Biomacromolecules 20090413
Management of patients with unstable angina / non-ST-elevation myocardial infarction: a critical review of the 2007 ACC /AHA guidelines. International journal of clinical practice 20090401
Successful use of bivalirudin for combined carotid endarterectomy and coronary revascularization with the use of cardiopulmonary bypass in a patient with an elevated heparin-platelet factor 4 antibody titer. Anesthesia and analgesia 20090401
Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions. Diabetes care 20090401
Cost-effectiveness analysis of anticoagulation strategies in non-ST-elevation acute coronary syndromes. The Annals of pharmacotherapy 20090401
Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. Journal of the American College of Cardiology 20090324
Abbreviated infusion of eptifibatide after successful coronary intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) randomized trial. Journal of the American College of Cardiology 20090310
Resolution of a coronary embolus by intravenous application of bivalirudin. International journal of cardiology 20090306
Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. Coronary artery disease 20090301
Bivalirudin use during PCI for stent thrombosis in a patient with subacute intracranial hemorrhage. The Journal of invasive cardiology 20090301
Clinical cross-reactivity between danaparoid and heparin antibodies successfully managed with bivalirudin. The Israel Medical Association journal : IMAJ 20090301
Bioline heparin-coated ECMO with bivalirudin anticoagulation in a patient with acute heparin-induced thrombocytopenia: the immune reaction appeared to continue unabated. Perfusion 20090301
Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study. Journal of the American College of Cardiology 20090224
Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial. Circulation 20090210
Relationship of QRS duration at baseline and changes over 60 min after fibrinolysis to 30-day mortality with different locations of ST elevation myocardial infarction: results from the Hirulog and Early Reperfusion or Occlusion-2 trial. Heart (British Cardiac Society) 20090201
Profile of bleeding and ischaemic complications with bivalirudin and unfractionated heparin after percutaneous coronary intervention. European heart journal 20090201
Heparin-induced thrombocytopenia: what clinicians need to know. Thrombosis and haemostasis 20090201
Bivalirudin reduces platelet and monocyte activation after elective percutaneous coronary intervention. Thrombosis and haemostasis 20090201
Pharmacotherapy of acute coronary syndrome: the ACUITY trial. Expert opinion on pharmacotherapy 20090201
HORIZONS trial: a step forward for primary percutaneous coronary intervention. Expert review of cardiovascular therapy 20090201
Impact of bivalirudin use on outcomes in nonagenarians undergoing percutaneous coronary intervention. Journal of interventional cardiology 20090201
Avoiding and managing bleeding complications in patients with non-ST-segment elevation acute coronary syndromes. Angiology 20090101
Cloning and expression of a new recombinant thrombolytic and anthithrombotic agent - a staphylokinase variant. Acta biochimica Polonica 20090101
Clinical experience with the use of bivalirudin in a large population undergoing endovascular abdominal aortic aneurysm repair. Journal of vascular and interventional radiology : JVIR 20090101
Re-evaluating risk factors for periprocedural complications during percutaneous coronary intervention in patients with unstable angina/non-ST-elevation myocardial infarction: who may benefit from more intensive antiplatelet therapy? Current opinion in cardiology 20090101
Antiplatelet intervention in acute coronary syndrome. American journal of therapeutics 20090101
Catheter-related thrombosis: biological and clinical evidence for risk with currently available anticoagulants. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20090101
Use of clopidogrel in the reduction of myocardial damage during percutaneous coronary intervention. Vascular health and risk management 20090101
Bivalirudin anticoagulation during cardiac surgery: a single-center experience in 141 patients. Perfusion 20090101
Improving adjunctive pharmacotherapy for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: beyond the HORIZONS-AMI trial. Reviews in cardiovascular medicine 20090101
Head-to-head comparison of bivalirudin versus heparin without glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction undergoing primary angioplasty. Cardiovascular revascularization medicine : including molecular interventions 20090101
The in vitro effect of eptifibatide, a glycoprotein IIb/IIIa antagonist, on various responses of porcine blood platelets. Acta poloniae pharmaceutica 20090101
Appearance of microvascular obstruction on high resolution first-pass perfusion, early and late gadolinium enhancement CMR in patients with acute myocardial infarction. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20090101
Selecting the optimal antithrombotic regimen for patients with acute coronary syndromes undergoing percutaneous coronary intervention. Vascular health and risk management 20090101
[Bivalirudine in heparin-induced thrombocytopenia]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101
Intracoronary versus intravenous abciximab in ST-segment elevation myocardial infarction: rationale and design of the CICERO trial in patients undergoing primary percutaneous coronary intervention with thrombus aspiration. Trials 20090101
Review of the treatment of acute coronary syndrome in elderly patients. Clinical interventions in aging 20090101
Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation. Hematology. American Society of Hematology. Education Program 20090101
Eptifibatide: The evidence for its role in the management of acute coronary syndromes. Core evidence 20090101
Bivalirudin for anticoagulation in children. Pediatric blood & cancer 20081201
Differential effects of factor IIa inhibitors on the endogenous thrombin potential. Therapeutic drug monitoring 20081201
Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase. Journal of thrombosis and haemostasis : JTH 20081201
Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature. Pharmacotherapy 20081201
[Pharmacology of heparins and direct anticoagulants]. Hamostaseologie 20081201
Emergence of new oral antithrombotics: a critical appraisal of their clinical potential. Vascular health and risk management 20081201
Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. JACC. Cardiovascular interventions 20081201
Economic evaluation of bivalirudin with or without glycoprotein IIb/IIIa inhibition versus heparin with routine glycoprotein IIb/IIIa inhibition for early invasive management of acute coronary syndromes. Journal of the American College of Cardiology 20081125
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase. The Journal of pharmacology and experimental therapeutics 20081101
Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases. Pharmacotherapy 20081101
Successful use and dosing of bivalirudin after temporary total artificial heart implantation: a case series. Pharmacotherapy 20081101
'Bail-out' bivalirudin use in patients with thrombotic complications unresponsive to conventional treatment during percutaneous coronary intervention. The Journal of invasive cardiology 20081101
IIb or not IIb. Journal of the American College of Cardiology 20081007
Coronary stenting with MGuard: first-in-man trial. The Journal of invasive cardiology 20081001
Percutaneous coronary intervention and the use of glycoprotein IIb/IIIa inhibitors in patients with chronic kidney disease on dialysis: a single center experience. Hemodialysis international. International Symposium on Home Hemodialysis 20081001
Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis. Results of an in-vitro study. Thrombosis and haemostasis 20081001
The use of adjunctive anticoagulants in patients with acute coronary syndrome transitioning to percutaneous coronary intervention. The American journal of emergency medicine 20081001
[The HORIZONS-AMI trial]. Giornale italiano di cardiologia (2006) 20081001
Bivalirudin reduced major bleeding and adverse events in patients with STEMI having PCI. ACP journal club 20080916
Safety and efficacy of bivalirudin with and without glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention 1-year results from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. Journal of the American College of Cardiology 20080902
[Antithrombotic therapy of acute myocardial infarction]. Der Internist 20080901
Bivalirudin for patients with heparin-induced thrombocytopenia undergoing cardiovascular surgery. The Annals of pharmacotherapy 20080901
Safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia. Pharmacotherapy 20080901
Simultaneous integrated coronary artery revascularization with long-term angiographic follow-up. The Journal of thoracic and cardiovascular surgery 20080901
Lepirudin in the management of patients with heparin-induced thrombocytopenia. Biologics : targets & therapy 20080901
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. The New England journal of medicine 20080814
Bivalirudin with provisional glycoprotein IIb/IIIa inhibitors in patients undergoing primary angioplasty in the setting of cardiogenic shock. The American journal of cardiology 20080801
Optimizing antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndrome. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080801
Advances in antithrombotic therapy as adjunct to reperfusion therapies for ST-segment elevation myocardial infarction. Thrombosis and haemostasis 20080801
Antons syndrome in a patient with type-2 heparin-induced thrombocytopaenia (HIT). Acta anaesthesiologica Scandinavica 20080801
Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion. Journal of interventional cardiology 20080801
Pharmacological prevention of peri-, and post-procedural myocardial injury in percutaneous coronary intervention. Current cardiology reviews 20080801
Bleeding risk and outcomes of Bivalirudin versus Glycoprotein IIb/IIIa inhibitors with targeted low-dose unfractionated Heparin in patients having percutaneous coronary intervention for either stable or unstable angina pectoris. The American journal of cardiology 20080715
Successful use of bivalirudin for superior vena cava recanalization and stent placement in a child with heparin-induced thrombocytopenia. Pediatric cardiology 20080701
Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Current opinion in cardiology 20080701
2007 Guideline update for unstable angina/non-ST-segment elevation myocardial infarction: focus on antiplatelet and anticoagulant therapies. The Annals of pharmacotherapy 20080701
Low plasma fibrinogen levels with the Clauss method during anticoagulation with bivalirudin. Anesthesiology 20080701
The Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial: study design and rationale. American heart journal 20080701
Treatment of ST-elevation myocardial infarction. Future cardiology 20080701
Reperfusion strategies in ST-elevation myocardial infarction--current status and perspectives for early and pre-hospital treatment. Resuscitation 20080601
[Direct thrombin inhibitors: pharmacology and application in cardiovascular anesthesia]. Der Anaesthesist 20080601
Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention. European heart journal 20080601
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
[The ACUITY trial: one-year results]. Giornale italiano di cardiologia (2006) 20080601
The use of fondaparinux for the treatment of venous thromboembolism in a patient with heparin-induced thombocytopenia and thrombosis caused by heparin flushes. Therapeutics and clinical risk management 20080601
Percutaneous coronary intervention in patients with acute coronary syndrome: focus on bivalirudin. Vascular health and risk management 20080601
Bivalirudin during primary PCI in acute myocardial infarction. The New England journal of medicine 20080522
Antithrombotic therapy to support primary PCI. The New England journal of medicine 20080522
Safety and efficacy of switching from either unfractionated heparin or enoxaparin to bivalirudin in patients with non-ST-segment elevation acute coronary syndromes managed with an invasive strategy: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. Journal of the American College of Cardiology 20080506
New anticoagulant agents: direct thrombin inhibitors. Cardiology clinics 20080501
What anti-thrombotic therapy is best with primary PCI for acute ST elevation myocardial infarction: how should the HORIZONS trial change current practice? Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080501
Antiplatelet therapy in early management of non-ST-segment elevation acute coronary syndrome: the 2002 and 2007 guidelines from North America and Europe. Journal of cardiovascular pharmacology 20080501
Review of the 2005 American College of Cardiology, American Heart Association, and Society for Cardiovascular Interventions guidelines for adjunctive pharmacologic therapy during percutaneous coronary interventions: practical implications, new clinical data, and recommended guideline revisions. American heart journal 20080501
Off-pump exchange of short-term percutaneous ventricular assist device (VAD) to long-term implantable VAD in severe coagulopathy and multi-organ failure. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20080501
Bivalirudin. Thrombosis and haemostasis 20080501
[Bivalirudin and cardiac surgery: two case reports]. Giornale italiano di cardiologia (2006) 20080501
The Role of Glycoprotein IIb/IIIa Inhibitors- A Promise Not Kept? Current cardiology reviews 20080501
Safety and efficacy of bivalirudin monotherapy in patients with diabetes mellitus and acute coronary syndromes: a report from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. Journal of the American College of Cardiology 20080429
Current update on glycoprotein IIb-IIIa and direct thrombin inhibition in percutaneous coronary intervention for non-ST elevation acute coronary syndromes: balancing bleeding risk and antiplatelet efficacy. Journal of interventional cardiology 20080401
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20080401
Antithrombotic agents for acute coronary syndromes. Cardiovascular & hematological agents in medicinal chemistry 20080401
New anticoagulant strategies in ST elevation myocardial infarction: trials and clinical implications. Vascular health and risk management 20080401
Adjunct bivalirudin dosing protocol for neuro-endovascular procedures. Journal of vascular and interventional neurology 20080401
High-dose aprotinin effectively reduces blood loss during on-pump coronary artery bypass grafting with bivalirudin anticoagulation. The Journal of thoracic and cardiovascular surgery 20080301
Ischaemic events and bleeding in patients undergoing percutaneous coronary intervention with concomitant bivalirudin treatment. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20080301
Abciximab: a reappraisal of its use in coronary care. Biologics : targets & therapy 20080301
Adjunct thrombus aspiration reduces mortality in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction with high-risk angiographic characteristics. The American journal of cardiology 20080215
'Off-label' stent therapy 2-year comparison of drug-eluting versus bare-metal stents. Journal of the American College of Cardiology 20080212
Acute left atrial thrombus after recombinant factor VIIa administration during left ventricular assist device implantation in a patient with heparin-induced thrombocytopenia. Anesthesia and analgesia 20080201
Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS medicine 20080201
[Anticoagulation in acute coronary syndrome. An update]. Hamostaseologie 20080201
Recent developments in acute coronary syndromes. Clinical medicine (London, England) 20080201
The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update. Seminars in thrombosis and hemostasis 20080201
Routine use of the direct thrombin inhibitor bivalirudin for off-pump coronary artery bypass grafting is safe and effective. The heart surgery forum 20080101
Pharmacological strategies for inhibition of thrombin activity. Current pharmaceutical design 20080101
Safety and efficacy of bivalirudin in acute coronary syndromes. Current pharmaceutical design 20080101
Pharmacoeconomics of anticoagulants in acute coronary syndrome and percutaneous coronary intervention. Current pharmaceutical design 20080101
Monitoring of bivalirudin anticoagulation during and after cardiopulmonary bypass using an ecarin-activated TEG system. Journal of cardiac surgery 20080101
A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper. Journal of cardiothoracic surgery 20080101
Use of bivalirudin to prevent thrombosis following orthotopic liver transplantation in a patient with Budd-Chiari syndrome and a history of heparin-induced thrombocytopenia. Annals of clinical and laboratory science 20080101
Effect of modified ultrafiltration on bivalirudin elimination and postoperative blood loss after on-pump coronary artery bypass grafting: assessment of different filtration strategies. Journal of cardiac surgery 20080101
Heparin-induced thrombocytopenia: diagnosis and management. Thrombosis research 20080101
Brave new world: the current and future use of novel anticoagulants. Thrombosis research 20080101
Antithrombotic therapies in primary angioplasty: rationale, results and future directions. Drugs 20080101
Bivalirudin: in patients with acute coronary syndromes : planned for urgent or early intervention. Drugs 20080101
New anticoagulants in children. Hematology. American Society of Hematology. Education Program 20080101
Implementing an innovative consent form: the PREDICT experience. Implementation science : IS 20080101
Quest for 'innovative strategies' in primary PCI: clot busters or devices (protection vs suction) or both? A story in search of an end. Indian heart journal 20080101
Antithrombotics for PCI: an indigenous direct thrombin inhibitor (DTI) makes the cut. Indian heart journal 20080101
Safety and efficacy of indigenously developed and manufactured bivalirudin in moderate/high-risk Indian patients undergoing percutaneous coronary intervention: the Bivaflo Registry. Indian heart journal 20080101
Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management: one-year results from the ACUITY trial. JAMA 20071205
Thrombin-activated thrombelastography for evaluation of thrombin interaction with thrombin inhibitors. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201
Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY. Cardiovascular drugs and therapy 20071201
[Direct thrombin inhibition in interventional cardiology. The ACUITY trial]. Hamostaseologie 20071201
Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions. Journal of cardiovascular pharmacology and therapeutics 20071201
[Gp IIb/IIIa receptor antagonists in acute coronary syndromes with no ST elevation]. Archives des maladies du coeur et des vaisseaux 20071201
Focus on thrombin: alternative anticoagulants. Seminars in cardiothoracic and vascular anesthesia 20071201
Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 Trial. The American journal of cardiology 20071101
Survey of pharmacist-managed inpatient anticoagulation services. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071101
Drug-induced immune thrombocytopenia. The New England journal of medicine 20071101
Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick. The Journal of biological chemistry 20071005
Impact of bivalirudin on outcomes after percutaneous coronary revascularization with drug-eluting stents. American heart journal 20071001
Thrombin generation assay and viscoelastic coagulation monitors demonstrate differences in the mode of thrombin inhibition between unfractionated heparin and bivalirudin. Anesthesia and analgesia 20071001
Emergency percutaneous coronary intervention (PCI) for the care of patients with ST-elevation myocardial infarction (STEMI). Minerva cardioangiologica 20071001
[Heparin-induced thrombocytopenia]. Revista espanola de cardiologia 20071001
[Optimizing antithrombotic therapy in non-ST-elevation acute coronary syndrome]. Revista espanola de cardiologia 20071001
Does bivalirudin reduce the incidence of bleeding in patients with acute coronary syndromes undergoing PCI? Nature clinical practice. Cardiovascular medicine 20070901
Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies. The Annals of thoracic surgery 20070901
Invited commentary. The Annals of thoracic surgery 20070901
Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070901
Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia. Current cardiology reports 20070901
Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. Cardiovascular & hematological disorders drug targets 20070901
Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils. Arteriosclerosis, thrombosis, and vascular biology 20070801
Comparison of platelet function and morphology in patients undergoing percutaneous coronary intervention receiving bivalirudin versus unfractionated heparin versus clopidogrel pretreatment and bivalirudin. The American journal of cardiology 20070801
Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis. Journal of thrombosis and haemostasis : JTH 20070801
Direct thrombin inhibition with bivalirudin as an antithrombotic strategy in general and interventional cardiology. Expert opinion on drug metabolism & toxicology 20070801
Beyond unfractionated heparin and warfarin: current and future advances. Circulation 20070731
Influence of bivalirudin on tissue factor-triggered coagulation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070701
Monitoring direct thrombin inhibitors with a plasma diluted thrombin time. Thrombosis and haemostasis 20070701
New anticoagulant options for ST-elevation myocardial infarction and unstable angina pectoris/non-ST-elevation myocardial infarction. Current cardiology reports 20070701
Interatrial septal defect closure for cerebrovascular accidents: exploring the role of various anticoagulants. The Journal of invasive cardiology 20070701
Antithrombotic strategies in non-ST elevation acute coronary syndromes: focus on bivalirudin. Future cardiology 20070701
Association of prerandomization anticoagulant switching with bleeding in the setting of percutaneous coronary intervention (A REPLACE-2 analysis). The American journal of cardiology 20070615
Variations in the use of emergency PCI for the treatment of re-infarction following intravenous fibrinolytic therapy: impact on outcomes in HERO-2. European heart journal 20070601
Managing acute coronary syndrome: evidence-based approaches. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070601
Temporal trends, safety, and efficacy of bivalirudin in elective percutaneous coronary intervention: insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. Journal of interventional cardiology 20070601
Effect of anemia on hemorrhagic complications and mortality following percutaneous coronary intervention. The American journal of cardiology 20070601
Fondaparinux as a treatment option for heparin-induced thrombocytopenia. Pharmacotherapy 20070601
The direct thrombin inhibitor argatroban: a review of its use in patients with and without HIT. Biologics : targets & therapy 20070601
Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. European heart journal 20070501
Comparison of patient outcomes with bivalirudin versus unfractionated heparin in percutaneous coronary intervention. Pharmacotherapy 20070501
Successful use of bivalirudin as anticoagulant for ECMO in a patient with acute HIT. The Annals of thoracic surgery 20070501
The safety of a bivalirudin-based approach in patients undergoing rotational atherectomy. The Journal of invasive cardiology 20070501
Anticoagulant therapy in acute coronary syndromes. Future cardiology 20070501
Heparin resistance in acute coronary syndromes. Journal of thrombosis and thrombolysis 20070401
Heparin-induced thrombocytopenia: treatment options and special considerations. Pharmacotherapy 20070401
Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin). The American journal of cardiology 20070401
Enoxaparin injection for the treatment of high-risk patients with non-ST elevation acute coronary syndrome. Vascular health and risk management 20070401
Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial. Journal of the American College of Cardiology 20070327
ACUITY-PCI: one drug does not fit all. Lancet (London, England) 20070317
Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet (London, England) 20070317
Bivalirudin in acute coronary syndromes. The New England journal of medicine 20070308
Bivalirudin in acute coronary syndromes. The New England journal of medicine 20070308
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301
Current incidence and clinical outcomes of bivalirudin administration among patients undergoing primary coronary intervention for stent thrombosis elevation acute myocardial infarction. Coronary artery disease 20070301
Transradial approach for carotid artery stenting: a feasibility study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20070215
Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. The Annals of thoracic surgery 20070201
Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat. Anesthesiology 20070201
Bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in drug-eluting stent implantations in the absence of acute myocardial infarction: clinical and economic results. The Journal of invasive cardiology 20070201
Bivalirudin and DES: a PCI strategy that pays. The Journal of invasive cardiology 20070201
Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20070201
Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. Expert review of cardiovascular therapy 20070101
Deep hypothermic circulatory arrest and bivalirudin use in a patient with heparin-induced thrombocytopenia and antiphospholipid syndrome. Journal of cardiac surgery 20070101
First human case description of TandemHeart-assisted high-risk percutaneous balloon aortic valvuloplasty using bivalirudin anticoagulation. The Journal of invasive cardiology 20070101
[The best of thrombosis in 2006]. Archives des maladies du coeur et des vaisseaux 20070101
Bivalirudin anticoagulation for cardiopulmonary bypass: an unusual case. Texas Heart Institute journal 20070101
Blood pressure and risks of vascular complications after percutaneous coronary intervention. Dimensions of critical care nursing : DCCN 20070101
Severe heparin-induced thrombocytopenia: when the obvious is not obvious, a case report. Journal of medical case reports 20070101
Evidence-based medical therapy of patients with acute coronary syndromes. American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101
Similar success rates with bivalirudin and unfractionated heparin in bare-metal stent implantation. Cardiovascular and interventional radiology 20070101
Sulodexide for hemodialysis anticoagulation in heparin-induced thrombocytopenia type II. Journal of nephrology 20070101
Interventional cardiology in Israel at 2005 - state of practice. Acute cardiac care 20070101
Use of activated recombinant factor VII for severe coagulopathy post ventricular assist device or orthotopic heart transplant. Journal of cardiothoracic surgery 20070101
Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy. Perfusion 20070101
Heparin-induced thrombocytopenia: a general review. Journal of infusion nursing : the official publication of the Infusion Nurses Society 20070101
Direct antithrombins: mechanisms, trials, and role in contemporary interventional medicine. American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101
Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors. Reviews in cardiovascular medicine 20070101
The use of antithrombotics for acute coronary syndromes in the emergency department: considerations and impact. Progress in cardiovascular diseases 20070101
Endovascular treatment of a renal artery stenosis: techniques, indications, results. Role of embolic protection devices (part 2). Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20070101
Glycoprotein IIb/IIIa inhibitors: questioning indications and treatment algorithms. Cardiovascular revascularization medicine : including molecular interventions 20070101
The safety of bivalirudin during elective percutaneous coronary interventions in heart transplant patients. Cardiology journal 20070101
[Anticoagulant therapy and cardiopulmonary bypass]. Archivos de cardiologia de Mexico 20070101
Bivalirudin: a new promising direct antithrombin. Indian heart journal 20070101
Heparin induced thrombocytopenia management with bivalirudin. Indian heart journal 20070101
Heparin-induced thrombocytopenia. The New England journal of medicine 20061214
Bivalirudin in percutaneous coronary intervention. Vascular health and risk management 20061201
Fondaparinux in the management of patients with ST-elevation acute myocardial infarction. Vascular health and risk management 20061201
Bivalirudin for patients with acute coronary syndromes. The New England journal of medicine 20061123
Accounting for ACUITY. The New England journal of medicine 20061123
Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart (British Cardiac Society) 20061101
Bolus-only platelet glycoprotein IIb-IIIa inhibition during percutaneous coronary intervention. The Journal of invasive cardiology 20061101
Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20061101
Angiographic and clinical outcomes of bivalirudin versus heparin in patients with acute coronary syndrome undergoing percutaneous coronary intervention. The Canadian journal of cardiology 20061101
Heparin-induced thrombocytopenia: a review. Seminars in thrombosis and hemostasis 20061101
Comparative cost-effectiveness of anticoagulation with bivalirudin or heparin with and without a glycoprotein IIb/IIIa-receptor inhibitor in patients undergoing percutaneous coronary intervention in Sweden: a decision-analytic model. Clinical therapeutics 20061101
[Clinical use of a new class of anticoagulant drugs: the direct thrombin inhibitors]. Giornale italiano di cardiologia (2006) 20061101
Recent developments in antithrombotic therapy: will sodium warfarin be a drug of the past? Recent patents on cardiovascular drug discovery 20061101
Successful percutaneous coronary intervention using bivalirudin in a patient with chronic lymphocytic leukemia and thrombocytopenia. European journal of haematology 20061001
Debate of adjunctive pharmacology for percutaneous coronary intervention: anticoagulation and clopidogrel are not (always) enough. Journal of interventional cardiology 20061001
Debate of adjunctive pharmacology for percutaneous coronary intervention: thrombin inhibitors and clopidogrel are enough. Journal of interventional cardiology 20061001
[Bivalirudin: a direct thrombin inhibitor in percutaneous coronary interventions]. Ugeskrift for laeger 20060918
Direct thrombin inhibition appears to be a safe and effective anticoagulant for percutaneous bypass graft interventions. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20060901
Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: results of the 'EVOLUTION OFF' trial. Anesthesia and analgesia 20060901
Risk stratification of patients with acute anterior myocardial infarction and right bundle-branch block: importance of QRS duration and early ST-segment resolution after fibrinolytic therapy. Circulation 20060822
Successful anticoagulation with bivalirudin in antithrombin-deficient pediatric patient undergoing stent placement. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20060801
Greater inhibitory effects of bivalirudin compared with unfractionated heparin plus eptifibitide on thrombin-induced platelet activation. Coronary artery disease 20060801
Switching from Enoxaparin to Bivalirudin in Patients with Acute Coronary Syndromes without ST-segment Elevation who Undergo Percutaneous Coronary Intervention. Results from SWITCH--a multicenter clinical trial. The Journal of invasive cardiology 20060801
Clinical end point definitions after percutaneous coronary intervention and their relationship to late mortality: an assessment by attributable risk. Heart (British Cardiac Society) 20060701
Heparin-induced thrombocytopenia and cardiovascular diseases. American heart journal 20060701
Outcomes of patients with acute coronary syndromes who are treated with bivalirudin during percutaneous coronary intervention: an analysis from the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE-2) trial. American heart journal 20060701
Provisional glycoprotein IIb/IIIa blockade in a randomized investigation of bivalirudin versus heparin plus planned glycoprotein IIb/IIIa inhibition during percutaneous coronary intervention: predictors and outcome in the Randomized Evaluation in Percutaneous coronary intervention Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial. American heart journal 20060701
Initial Q waves accompanying ST-segment elevation at presentation of acute myocardial infarction and 30-day mortality in patients given streptokinase therapy: an analysis from HERO-2. Lancet (London, England) 20060624
A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. Journal of the American College of Cardiology 20060620
The future of an illusion. Journal of the American College of Cardiology 20060620
Planned versus provisional use of glycoprotein IIb/IIIa inhibitors in smokers undergoing percutaneous coronary intervention. The American journal of cardiology 20060615
Bivalirudin for anticoagulation in mechanical aortic valve replacement and heparin-induced thrombocytopenia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20060601
Angiographic adverse events, creatine kinase-MB elevation, and ischemic end points complicating percutaneous coronary intervention (a REPLACE-2 substudy). The American journal of cardiology 20060601
Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060601
Bivalirudin anticoagulation for a patient with hypercoagulable immune syndromes undergoing mitral valve surgery. The Annals of thoracic surgery 20060601
Bivalirudin in peripheral interventions. Techniques in vascular and interventional radiology 20060601
Comparison of effects of bare metal versus drug-eluting stent implantation on biomarker levels following percutaneous coronary intervention for non-ST-elevation acute coronary syndrome. The American journal of cardiology 20060515
Measurement of patients' bivalirudin plasma levels by a thrombelastograph ecarin clotting time assay: a comparison to a standard activated clotting time. Anesthesia and analgesia 20060501
Cost-effectiveness analysis of antithrombotic therapy in nonurgent percutaneous coronary intervention. Pharmacotherapy 20060501
The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial (Am J Heart 2005;150:189-92). American heart journal 20060501
Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: a subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial. American heart journal 20060501
Evaluation of bivalirudin treatment for heparin-induced thrombocytopenia in critically ill patients with hepatic and/or renal dysfunction. Pharmacotherapy 20060401
Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia. Pharmacotherapy 20060401
Frequency of recurrent ST-elevation myocardial infarction after fibrinolytic therapy in a different territory as a manifestation of multiple unstable coronary arterial plaques. The American journal of cardiology 20060401
Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis. Circulation 20060307
Clinical development of bivalirudin (Angiox): rationale for thrombin-specific anticoagulation in percutaneous coronary intervention and acute coronary syndromes. International journal of clinical practice 20060301
Anticoagulation for cardiopulmonary bypass: is a replacement for heparin on the horizon? The Journal of thoracic and cardiovascular surgery 20060301
A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study. The Journal of thoracic and cardiovascular surgery 20060301
Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study. The Journal of thoracic and cardiovascular surgery 20060301
Anti-thrombotic effect of bivalirudin compared with eptifibatide and unfractionated heparin in diabetic patients: an ex vivo human study. Thrombosis and haemostasis 20060301
Transitioning from heparin to bivalirudin in patients undergoing ad hoc transradial interventional procedures: a pilot study. The Journal of invasive cardiology 20060301
Use of bivalirudin as the foundation anticoagulant during percutaneous peripheral interventions. The Journal of invasive cardiology 20060301
Emerging anticoagulants: mechanism of action and future potential. Vnitrni lekarstvi 20060301
Thrombin inhibitors and cardiopulmonary bypass. The journal of extra-corporeal technology 20060301
Platelet inhibitors in non-ST-segment elevation acute coronary syndromes and percutaneous coronary intervention: glycoprotein IIb/IIIa inhibitors, clopidogrel, or both? Vascular health and risk management 20060301
Treatment of heparin-induced thrombocytopenia in cardiovascular patients. Expert opinion on pharmacotherapy 20060201
Bivalirudin use in carotid endarterectomy in a patient with heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20060201
Case 1-2006: off-pump coronary artery bypass graft surgery anticoagulation with bivalirudin: a patient with heparin-induced thrombocytopenia syndrome type II and renal failure. Journal of cardiothoracic and vascular anesthesia 20060201
Treatment of heparin-induced thrombocytopenia: is there a role for bivalirudin? Pharmacotherapy 20060201
[Mechanism of thrombosis: physiopathology, role of thrombin and its inhibition by modern therapies]. Archives des maladies du coeur et des vaisseaux 20060201
[Direct thrombin inhibitors in coronary angioplasty. Value of bivalirudin ]. Archives des maladies du coeur et des vaisseaux 20060201
[Present and future developments of antithrombotic agents]. Archives des maladies du coeur et des vaisseaux 20060201
[Antithrombotic agents in clinical practice]. Archives des maladies du coeur et des vaisseaux 20060201
Use of bivalirudin to treat heparin-induced thrombocytopenia in a patient with idiopathic giant-cell myocarditis. Connecticut medicine 20060201
Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance. Journal of the American College of Cardiology 20060103
Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin. Thrombosis research 20060101
Inhibition of thrombin: relevance to anti-thrombosis strategy. Frontiers in bioscience : a journal and virtual library 20060101
Prognostic differences between different types of bundle branch block during the early phase of acute myocardial infarction: insights from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial. European heart journal 20060101
[The management of patients with heparin-induced thrombocytopenia]. Hamostaseologie 20060101
Heparin-induced thrombocytopenia and cardiovascular patients: recognition and treatment. Progress in cardiovascular nursing 20060101
Cardiopulmonary bypass for complex cardiac surgery using bivalirudin anticoagulation in a patient with heparin antibodies. Journal of cardiac surgery 20060101
When heparin causes thrombosis: significance, recognition, and management of heparin-induced thrombocytopenia in dialysis patients. Seminars in dialysis 20060101
Bivalirudin versus unfractionated heparin in patients undergoing percutaneous coronary intervention after acute myocardial infarction. Cardiovascular revascularization medicine : including molecular interventions 20060101
New anticoagulants. Hematology. American Society of Hematology. Education Program 20060101
A comparative study on the cost of new antibiotics and drugs of other therapeutic categories. PloS one 20060101
Practical guidelines for the use of anticoagulants in the catheterization laboratory. Reviews in cardiovascular medicine 20060101
Bivalirudin in acute coronary syndromes and percutaneous coronary intervention. Reviews in cardiovascular medicine 20060101
Platelet protagonist/antagonist: understanding the distinguishing characteristics of anticoagulants. Reviews in cardiovascular medicine 20060101
Economic implications of bivalirudin in the cardiac catheterization laboratory. Reviews in cardiovascular medicine 20060101
Evolving antithrombotic treatment strategies for acute ST-elevation myocardial infarction. Reviews in cardiovascular medicine 20060101
Carotid artery stenting with neuroprotection: assessing the learning curve and treatment outcome. American journal of surgery 20051201
Bivalirudin anticoagulation for cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20051201
Bivalirudin vs heparin in percutaneous coronary intervention: a pooled analysis. Journal of cardiovascular pharmacology and therapeutics 20051201
Bivalirudin: role in current percutaneous coronary intervention practice. British journal of hospital medicine (London, England : 2005) 20051201
[Direct and indirect antithrombins in acute coronary syndromes]. Wiener klinische Wochenschrift 20051201
Sensitivity of a modified ACT test to levels of bivalirudin used during cardiac surgery. The journal of extra-corporeal technology 20051201
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. Thrombosis and haemostasis 20051101
Adjunctive Antiplatelet / Antithrombotic therapy in percutaneous coronary intervention. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20051101
Bivalirudin: a direct thrombin inhibitor used during percutaneous coronary intervention. Future cardiology 20051101
Percutaneous coronary intervention-related bleeding risk factors in current practice. The Annals of pharmacotherapy 20051001
Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing. American journal of clinical pathology 20051001
Brachytherapy and bivalirudin evaluation study. American heart journal 20051001
The effects of bivalirudin compared with those of unfractionated heparin plus eptifibatide on inflammation and thrombin generation and activity during coronary intervention. Coronary artery disease 20050901
Effectiveness of the concomitant use of bivalirudin and drug-eluting stents (from the prospective, multicenter BivAlirudin and Drug-Eluting STents [ADEST] study). The American journal of cardiology 20050901
Bivalirudin as an anticoagulation agent: safety and efficacy in peripheral interventions. Journal of vascular and interventional radiology : JVIR 20050901
Heparin and other rapidly acting anticoagulants. Seminars in vascular surgery 20050901
Drug insight: bleeding after percutaneous coronary intervention-risks, measures and impact of anticoagulant treatment options. Nature clinical practice. Cardiovascular medicine 20050901
Use of bivalirudin as an anticoagulant during cardiopulmonary bypass. The journal of extra-corporeal technology 20050901
[Haemostaseology]. Der Internist 20050801
Routine bivalirudin use in percutaneous carotid interventions. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20050801
A safety and feasibility report of combined direct thrombin and GP IIb/IIIa inhibition with bivalirudin and tirofiban in peripheral vascular disease intervention: treating critical limb ischemia like acute coronary syndrome. The Journal of invasive cardiology 20050801
New antithrombotics in the prevention of thromboembolic disease. European journal of internal medicine 20050801
Should bivalirudin be the anticoagulant of choice for percutaneous coronary intervention? Nature clinical practice. Cardiovascular medicine 20050801
Patients with prolonged ischemic chest pain and presumed-new left bundle branch block have heterogeneous outcomes depending on the presence of ST-segment changes. Journal of the American College of Cardiology 20050705
Preemptive use of bivalirudin for urgent on-pump coronary artery bypass grafting in patients with potential heparin-induced thrombocytopenia. The Annals of thoracic surgery 20050701
Invited commentary. The Annals of thoracic surgery 20050701
Bivalirudin versus heparin as an antithrombotic agent in patients who undergo percutaneous saphenous vein graft intervention with a distal protection device. The American journal of cardiology 20050701
Direct thrombin inhibitors. Current cardiology reports 20050701
Predictors of in-hospital and 30-day complications of peripheral vascular interventions using bivalirudin as the primary anticoagulant: results from the APPROVE Registry. The Journal of invasive cardiology 20050701
Bivalirudin as an adjunct to acute coronary intervention in post-operative myocardial infarction. The Journal of invasive cardiology 20050701
Successful percutaneous coronary intervention in a patient with severe haemophilia A using bivalirudin as the sole procedural anticoagulant. Haemophilia : the official journal of the World Federation of Hemophilia 20050701
Bivalirudin: a review. Expert opinion on pharmacotherapy 20050701
Evolving management strategies for heparin-induced thrombocytopenia. Seminars in hematology 20050701
Update on heparin-induced thrombocytopenia and cardiovascular interventions. Seminars in hematology 20050701
Use of bivalirudin during percutaneous coronary intervention in patients with diabetes mellitus: an analysis from the randomized evaluation in percutaneous coronary intervention linking angiomax to reduced clinical events (REPLACE)-2 trial. Journal of the American College of Cardiology 20050621
Inhibition of platelet aggregation with eptifibatide, bivalirudin, and heparin in patients undergoing percutaneous coronary intervention receiving clopidogrel pretreatment (The PharmacoDynamic Evaluation of Angiomax, Clopidogrel with or without INtegrilin [DEACON] study). The American journal of cardiology 20050615
Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study. The Journal of thoracic and cardiovascular surgery 20050601
What is the learning curve for carotid artery stenting with neuroprotection? Analysis of 200 consecutive cases at an academic institution. Perspectives in vascular surgery and endovascular therapy 20050601
[Direct inhibition of thrombin. A new strategy for the treatment of atrial fibrillation and acute coronary syndrome?]. Herz 20050501
Safety and feasibility of Bivalirudin with either Cypher and Taxus drug-eluting stent during percutaneous coronary intervention. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20050501
Effectiveness and safety of bivalirudin during percutaneous coronary intervention in a single medical center. The American journal of cardiology 20050315
Bivalirudin versus heparin and glycoprotein IIb/IIIa inhibition among patients with renal impairment undergoing percutaneous coronary intervention (a subanalysis of the REPLACE-2 trial). The American journal of cardiology 20050301
Optimizing management of hirudin anticoagulation. The journal of extra-corporeal technology 20050301
Diagnosis and management of heparin-induced thrombocytopenia. Expert review of cardiovascular therapy 20050301
PCI with bivalirudin and provisional GP IIb/IIIa inhibition is more cost-effective than heparin plus routine GP IIb/IIIa inhibition. Commentary. Evidence-based cardiovascular medicine 20050301
New anticoagulants for the prevention and treatment of venous thromboembolism. Vascular health and risk management 20050301
Eptifibatide-associated acute, profound thrombocytopenia. The Annals of pharmacotherapy 20050201
Direct thrombin inhibitors (part 2 of 2). The Journal of invasive cardiology 20050201
Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050201
Complications in peripheral vascular interventions: emerging role of direct thrombin inhibitors. Journal of vascular and interventional radiology : JVIR 20050201
Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050101
Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors. American heart journal 20050101
Thrombin-directed inhibitors: pharmacology and clinical use. American heart journal 20050101
[The best of thrombosis in 2004]. Archives des maladies du coeur et des vaisseaux 20050101
Safety of bivalirudin during percutaneous coronary interventions in patients with abnormal renal function. International journal of cardiovascular interventions 20050101
Anticoagulation management and cardiac surgery in patients with heparin-induced thrombocytopenia. Seminars in thoracic and cardiovascular surgery 20050101
Bivalirudin: a review of its use in patients undergoing percutaneous coronary intervention. Drugs 20050101
Anticoagulant use in patients with chronic renal impairment. American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Antiplatelet agents in patients undergoing percutaneous coronary intervention: how many and how much? American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Adoption of Angiomax at Christus Santa Rosa Medical Center decreases costs and increases satisfaction. The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators 20050101
Heparin-induced thrombocytopenia: an update. Thrombosis journal 20050101
New trends in anticoagulant treatments. Lupus 20050101
Bivalirudin compared with IIb/IIIa inhibitors in patients with in-stent restenosis undergoing intracoronary brachytherapy. Cardiovascular revascularization medicine : including molecular interventions 20050101
Intracoronary macrothrombus formation during percutaneous coronary intervention despite optimal activated clotting time using bivalirudin--a case report. Angiology 20050101
A successful anticoagulation protocol for the first HeartMate II implantation in the United States. Texas Heart Institute journal 20050101
Bivalirudin: pharmacology and clinical applications. Cardiovascular drug reviews 20050101
Severe argatroban-induced coagulopathy in a patient with a history of heparin-induced thrombocytopenia. The Annals of thoracic surgery 20041201
Cardiopulmonary bypass with bivalirudin in type II heparin-induced thrombocytopenia. The Annals of thoracic surgery 20041201
Effect of bivalirudin on length of stay in the recovery area after percutaneous coronary intervention compared with heparin alone, heparin + abciximab, or heparin + eptifibatide. The American journal of cardiology 20041201
Drugs for percutaneous coronary interventions. The Medical letter on drugs and therapeutics 20041201
Current role of antithrombotic agents in the treatment of acute coronary syndromes. Seminars in thrombosis and hemostasis 20041201
Anticoagulant monitoring techniques in a heparin-induced thrombocytopenia patient undergoing cardiopulmonary bypass using bivalirudin anticoagulant. The journal of extra-corporeal technology 20041201
Economic evaluation of bivalirudin with provisional glycoprotein IIB/IIIA inhibition versus heparin with routine glycoprotein IIB/IIIA inhibition for percutaneous coronary intervention: results from the REPLACE-2 trial. Journal of the American College of Cardiology 20041102
Economic impact of new interventional therapies: are we asking the right questions? Journal of the American College of Cardiology 20041102
Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: study design and rationale. American heart journal 20041101
The Angiomax Peripheral Procedure Registry of Vascular Events Trial (APPROVE): in-hospital and 30-day results. The Journal of invasive cardiology 20041101
Bivalirudin versus heparin as an antithrombotic agent in patients treated with a sirolimus-eluting stent. The American journal of cardiology 20041015
Novel antithrombotic agents: indirect synthetic inhibitors of factor Xa and direct thrombin inhibitors. Evidences from clinical studies. Current medicinal chemistry. Cardiovascular and hematological agents 20041001
Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing. Archives of pathology & laboratory medicine 20041001
Lack of clopidogrel pretreatment effect on the relative efficacy of bivalirudin with provisional glycoprotein IIb/IIIa blockade compared to heparin with routine glycoprotein IIb/IIIa blockade: a REPLACE-2 substudy. Journal of the American College of Cardiology 20040915
Value of monitoring activated clotting time when bivalirudin is used as the sole anticoagulation agent for percutaneous coronary intervention. The American journal of cardiology 20040915
Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. The Annals of pharmacotherapy 20040901
Use of bivalirudin instead of heparin during a percutaneous coronary intervention in a patient with severe thrombocytopenia. The Journal of invasive cardiology 20040901
Anticoagulation with bivalirudin during percutaneous coronary intervention for ST-segment elevation myocardial infarction. The Journal of invasive cardiology 20040901
Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 20040901
Antithrombotic therapy during percutaneous coronary intervention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 20040901
Visual compatibility of bivalirudin with selected drugs. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040901
Relationship between activated clotting time and ischemic or hemorrhagic complications: analysis of 4 recent randomized clinical trials of percutaneous coronary intervention. Circulation 20040824
Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial. JAMA 20040811
An overview of antithrombins in peripheral vascular interventions. The Journal of invasive cardiology 20040801
Unfractionated heparin in cardiology: redefining the standard of practice. Pharmacotherapy 20040801
Current and future antithrombotic agents in children. Expert review of cardiovascular therapy 20040701
Direct antithrombins: new perspectives in cardiovascular medicine. Current medicinal chemistry. Cardiovascular and hematological agents 20040701
Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia. Anesthesia and analgesia 20040601
Successful multi-vessel percutaneous coronary intervention with bivalirudin in a patient with severe hemophilia A: a case report and review of literature. The Journal of invasive cardiology 20040601
Bivalirudin-associated intracoronary thrombosis during gamma-brachytherapy and its experimental validation in acute swine model. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20040601
Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20040601
The use of direct thrombin inhibitors in cardiovascular surgery in patients with heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20040601
Bivalirudin in PCI: an overview of the REPLACE-2 trial. Seminars in thrombosis and hemostasis 20040601
Bivalirudin, blood loss, and graft patency in coronary artery bypass surgery. Seminars in thrombosis and hemostasis 20040601
Plasma-modified ACT can be used to monitor bivalirudin (Angiomax) anticoagulation for on-pump cardiopulmonary bypass surgery in a patient with heparin-induced thrombocytopenia. The journal of extra-corporeal technology 20040601
Validation of the i-STAT handheld activated clotting time for use with bivalirudin. The American journal of cardiology 20040515
Resolution of intracoronary thrombus with direct thrombin inhibition in a cocaine abuser. Heart (British Cardiac Society) 20040501
Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events [REPLACE]-1 trial). The American journal of cardiology 20040501
The use of bivalirudin to prevent subacute thrombosis during drug-eluting stent implantation. The Journal of invasive cardiology 20040501
New anticoagulation. The Journal of invasive cardiology 20040501
Novel uses for current and future direct thrombin inhibitors: focus on ximelagatran and bivalirudin. Expert opinion on investigational drugs 20040501
Liquid chromatography method for determination of bivalirudin in human plasma and urine using automated ortho-phthalaldehyde derivatization and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405
Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. American journal of clinical pathology 20040401
Bivalirudin versus heparin and protamine in off-pump coronary artery bypass surgery. The Annals of thoracic surgery 20040301
Bivalirudin: an anticoagulant option for percutaneous coronary intervention. Expert review of cardiovascular therapy 20040301
Bivalent direct thrombin inhibitors: hirudin and bivalirudin. Best practice & research. Clinical haematology 20040301
Selective use of bivalirudin to reduce post-PCI vascular complications. Critical pathways in cardiology 20040301
Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting. The American journal of cardiology 20040201
Antibodies against lepirudin are polyspecific and recognize epitopes on bivalirudin. Blood 20040115
Bivalirudin for endovascular intervention in acute ischemic stroke: case report. Neurosurgery 20040101
Benefits of direct angioplasty for women and men with acute myocardial infarction: results of the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes Angioplasty (GUSTO II-B) Angioplasty Substudy. American heart journal 20040101
Direct thrombin inhibitors for anticoagulation. The Annals of pharmacotherapy 20040101
Adjunctive use of direct thrombin inhibitors in patients receiving fibrinolytic therapy for acute myocardial infarction. American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101
Point-of-care ecarin clotting time versus activated clotting time in correlation with bivalirudin concentration. Thrombosis research 20040101
Addition of heparin to contrast media is associated with increased bleeding and peripheral vascular complications during percutaneous coronary intervention with bivalirudin and drug-eluting stents. Cardiovascular radiation medicine 20040101
[Oral antithrombins and the future of antithrombotic therapy]. Revista espanola de cardiologia 20040101
Clinical potential of oral direct thrombin inhibitors in the prevention and treatment of venous thromboembolism. Drugs 20040101
Update on acute coronary syndromes and implications for therapy. Expert opinion on investigational drugs 20031201
Heparin-induced thrombocytopenia and cardiac surgery. The Annals of thoracic surgery 20031201
Bivalirudin as alternative to both danaparoid and heparin in off-pump coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery 20031201
Bivalirudin alone in the treatment of acute myocardial infarction. The Journal of invasive cardiology 20031201
Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis. Circulation 20031125
Comparison of effectiveness and safety of three different antithrombotic regimens (bivalirudin, eptifibatide, and heparin) in preventing myocardial ischemia during percutaneous coronary intervention. The American journal of cardiology 20031101
The anticoagulant therapy with bivalirudin to assist in the performance of percutaneous coronary intervention in patients with heparin-induced thrombocytopenia (ATBAT) study: main results. The Journal of invasive cardiology 20031101
Advances in antithrombin therapy for ST-elevation myocardial infarction. Chinese medical journal 20031101
Bivalirudin provides increasing benefit with decreasing renal function: a meta-analysis of randomized trials. The American journal of cardiology 20031015
Direct thrombin inhibitor therapy in the cardiovascular patient. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031015
Argatroban for off-pump coronary artery bypass surgery. Anesthesia and analgesia 20031001
Direct thrombin inhibitors for non-ST-segment elevation acute coronary syndromes: what, when, and where? American heart journal 20031001
Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia. Journal of cardiothoracic and vascular anesthesia 20031001
Bivalirudin in percutaneous coronary intervention. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030915
Peptidomimetic thrombin inhibitors. Pathophysiology of haemostasis and thrombosis 20030901
Can bivalirudin and provisional GP IIb/IIIa blockade REPLACE heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention? Expert opinion on pharmacotherapy 20030801
Contemporary use of antiplatelet therapies in percutaneous coronary interventions. Coronary artery disease 20030801
Heparin-induced thrombocytopenia and cardiac surgery. The Annals of thoracic surgery 20030801
Current anticoagulant therapy--unmet clinical needs. Thrombosis research 20030715
Economic impact of bleeding complications and the role of antithrombotic therapies in percutaneous coronary intervention. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030715
Bivalirudin in peripheral vascular interventions: a single center experience. The Journal of invasive cardiology 20030701
Bivalirudin use in off-pump myocardial revascularization in patients with heparin-induced thrombocytopenia [corrected]. The Annals of thoracic surgery 20030701
Hirulog-like peptide reduces restenosis and expression of tissue factor and transforming growth factor-beta in carotid artery of atherosclerotic rabbits. Atherosclerosis 20030701
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. The Journal of invasive cardiology 20030601
Evolving role of bivalirudin in percutaneous coronary interventions; impact of the REPLACE-2 study. Expert opinion on investigational drugs 20030601
An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study. Anesthesia and analgesia 20030501
Correlation of point-of-care ecarin clotting time versus activated clotting time with bivalirudin concentrations. The American journal of cardiology 20030501
In-hospital complications of peripheral vascular interventions using unfractionated heparin as the primary anticoagulant. The Journal of invasive cardiology 20030501
Direct thrombin inhibitors. Expert opinion on pharmacotherapy 20030501
Predicting the pharmacology of thrombin inhibitors. Journal of thrombosis and haemostasis : JTH 20030501
Anticoagulation in acute cardiac care in patients with chronic kidney disease. American heart journal 20030401
Management of thrombotic and cardiovascular disorders in the new millenium. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20030401
Safe and efficacious use of bivalirudin for percutaneous coronary intervention with adjunctive platelet glycoprotein IIb/IIIa receptor inhibition. The American journal of cardiology 20030315
Informed consent during the clinical emergency of acute myocardial infarction (HERO-2 consent substudy): a prospective observational study. Lancet (London, England) 20030315
Bivalirudin (Angiomax) use during intracoronary brachytherapy may predispose to acute closure. Journal of cardiovascular pharmacology and therapeutics 20030301
Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA 20030219
Should bivalirudin replace heparin during percutaneous coronary interventions? JAMA 20030219
The evolving role of direct thrombin inhibitors in acute coronary syndromes. Journal of the American College of Cardiology 20030219
Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass. Anesthesia and analgesia 20030201
Clinician update: direct thrombin inhibitors in acute coronary syndromes. Journal of thrombosis and thrombolysis 20030201
Alternative methods of anticoagulation for dialysis-dependent patients with heparin-induced thrombocytopenia. Seminars in dialysis 20030101
Favorable outcome with bivalirudin anticoagulation during cardiopulmonary bypass. The Annals of thoracic surgery 20030101
Direct thrombin inhibitors in cardiac disease. Cardiovascular toxicology 20030101
A 24-hour continuous infusion study of bivalirudin in the rat. International journal of toxicology 20030101
Effect of non-heparin thrombin antagonists on thrombin generation, platelet function, and clot structure in whole blood. Cell biochemistry and biophysics 20030101
New anticoagulants: current status and future potential. American journal of cardiovascular drugs : drugs, devices, and other interventions 20030101
Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery. The Annals of thoracic surgery 20021201
A Bayesian ordinal model for heterogeneity in a multi-centre myocardial infarction clinical trial. Statistics in medicine 20021030
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021001
Slowed ST segment recovery despite early infarct artery patency in patients with Q waves at presentation with a first acute myocardial infarction. Implications of initial Q waves on myocyte reperfusion. European heart journal 20020901
Direct thrombin inhibitors in acute coronary syndromes. Lancet (London, England) 20020810
Bivalirudin: a direct thrombin inhibitor for percutaneous transluminal coronary angioplasty. Pharmacotherapy 20020801
Bivalirudin, a bivalent, thrombin specific anticoagulant as an alternative to heparin in interventional procedures as an alternative to heparin in interventional procedures. Hamostaseologie 20020801
Direct thrombin inhibitors. Seminars in hematology 20020701
Pharmacology and clinical use of bivalirudin. The Annals of pharmacotherapy 20020601
Bivalirudin: an anticoagulant for acute coronary syndromes and coronary interventions. Expert opinion on pharmacotherapy 20020601
Absolute and relative truth in clinical trials. Lancet (London, England) 20020601
Clinical pharmacology of bivalirudin. Pharmacotherapy 20020601
Bivalirudin administration during percutaneous coronary intervention: emphasis on high-risk patients. Pharmacotherapy 20020601
A practical cost analysis of bivalirudin. Pharmacotherapy 20020601
The role of thrombin inhibition during percutaneous coronary intervention. Pharmacotherapy 20020601
Selective inhibition of coagulation factors: advances in antithrombotic therapy. Seminars in thrombosis and hemostasis 20020601
Bivalirudin pharmacokinetics and pharmacodynamics: effect of renal function, dose, and gender. Clinical pharmacology and therapeutics 20020601
Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary intervention. Journal of thrombosis and thrombolysis 20020601
Heparin, bivalirudin, and reduction of complications during percutaneous coronary intervention. Pharmacotherapy 20020601
Bivalirudin with planned or provisional abciximab versus low-dose heparin and abciximab during percutaneous coronary revascularization: results of the Comparison of Abciximab Complications with Hirulog for Ischemic Events Trial (CACHET). American heart journal 20020501
Direct thrombin inhibitors. Thrombosis research 20020501
Pharmacodynamic profile of the direct thrombin antagonist bivalirudin given in combination with the glycoprotein IIb/IIIa antagonist eptifibatide. American heart journal 20020401
Building a stronger foundation: improved antithrombin therapy with bivalirudin in percutaneous coronary intervention. The Journal of invasive cardiology 20020401
Overcoming heparin limitations in high-risk percutaneous coronary intervention: the alternative strategy-- replacing heparin with bivalirudin. The Journal of invasive cardiology 20020401
New drugs 2002. Part II. Nursing 20020401
Direct thrombin inhibitors for percutaneous coronary intervention in the current era of platelet glycoprotein IIb/IIIa inhibition. Journal of interventional cardiology 20020401
Percutaneous coronary intervention with bivalirudin anticoagulation, immediate sheath removal, and early ambulation: a feasibility study with implications for day-stay procedures. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20020301
Publication policy, informed consent, and the randomized clinical trial. American heart journal 20020201
Improved efficacy and less bleeding: further evidence of a unique uncoupling of benefit and risk with bivalirudin. American heart journal 20020201
Bivalirudin as a replacement for unfractionated heparin in unstable angina/non-ST-elevation myocardial infarction: observations from the TIMI 8 trial. The Thrombolysis in Myocardial Infarction. American heart journal 20020201
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet (London, England) 20020126
Bivalirudin: a direct thrombin inhibitor. Clinical therapeutics 20020101
Bivalirudin: a review of its potential place in the management of acute coronary syndromes. Drugs 20020101
[What is new in antithrombotic treatment?]. Annales de biologie clinique 20020101
Management of patients with acute coronary syndromes: what is the clinical role of direct thrombin inhibitors? Drugs 20020101
Optimal treatment and current situation in reperfusion after thrombolysis for acute myocardial infarction. Annals of medicine 20020101
Current anticoagulation options in percutaneous intervention: designing patient-specific strategies. Reviews in cardiovascular medicine 20020101
Reversing anticoagulants both old and new. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20020101
Current developments in antithrombotic therapy: the role of antithrombin agents. Pathophysiology of haemostasis and thrombosis 20020101
Heparin-induced thrombocytopenia: pathophysiology and new treatment options. Pathophysiology of haemostasis and thrombosis 20020101
A second look at bivalirudin. American heart journal 20011201
Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study. American heart journal 20011201
Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet (London, England) 20011201
Pharmacologic preservation of the hemostatic system during cardiac surgery. The Annals of thoracic surgery 20011101
[Fibrinolysis in myocardial infarction with EKG elevation. Optimization of myocardial reperfusion by treatment with antithrombotic agents]. Archives des maladies du coeur et des vaisseaux 20011101
Caspofungin acetate, bivalirudin. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011001
Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes. Current cardiology reports 20010901
New anticoagulants. American heart journal 20010801
Direct thrombin inhibitors: are they the future of anticoagulation? South Dakota journal of medicine 20010601
Development and current applications of thrombin-specific inhibitors. Current drug targets. Cardiovascular & haematological disorders 20010601
Advances in the development of thrombin inhibitors. Expert opinion on investigational drugs 20010501
Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombi. The American journal of pathology 20010501
Bivalirudin (Angiomax) for angioplasty. The Medical letter on drugs and therapeutics 20010430
[Direct thrombin antagonists]. Herz 20010401
Thrombin inhibitor approved for anticoagulation during angioplasty. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010301
From the Food and Drug Administration. JAMA 20010214
Direct and indirect antithrombins. Heparins, low molecular weight heparins, heparinoids, and hirudin. Clinics in geriatric medicine 20010201
Ecarin clotting time is sensitive to heparinoids: comparison of two different techniques. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20010101
Hirulog-like peptide reduces balloon catheter injury induced neointima formation in rat carotid artery without increase in bleeding tendency. Journal of vascular research 20010101
Bivalirudin: a new approach to anticoagulation. Heart disease (Hagerstown, Md.) 20010101
The use of bivalirudin in patients with renal impairment. The Journal of invasive cardiology 20001201
Hirulog-1 reduces expression of platelet-derived growth factor in neointima of rat carotid artery induced by balloon catheter injury. Journal of vascular research 20000101
Direct thrombin inhibitors. Haemostasis 19991201
Clinical outcomes of bivalirudin for ischemic heart disease. Circulation 19991116
Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model. Thrombosis and haemostasis 19980701
Transcellular signaling and pharmacological modulation of thrombin-induced production of plasminogen activator inhibitor-1 in vascular smooth muscle cells. Seminars in thrombosis and hemostasis 19980101
Inhibition by hirulog-1 of generation of plasminogen activator inhibitor-1 from vascular smooth-muscle cells induced by thrombin. Journal of cardiovascular pharmacology 19970301
Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans. Thrombosis and haemostasis 19930201
Thrombin-specific inhibition by and slow cleavage of hirulog-1. The Biochemical journal 19920501
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