5,7-Dichlorokynurenic acid
| Title | Journal |
|---|---|
| 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. | European journal of medicinal chemistry 20120801 |
| Arrangement of subunits in functional NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
| Peripheral administration of NR2 antagonists attenuates orofacial formalin-induced nociceptive behavior in rats. | Progress in neuro-psychopharmacology & biological psychiatry 20110601 |
| Protein kinase C modulates NMDA receptors in the myenteric plexus of the guinea pig ileum during in vitro ischemia and reperfusion. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110201 |
| Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats. | Journal of orofacial pain 20100101 |
| Kinetic basis of partial agonism at NMDA receptors. | Nature neuroscience 20090901 |
| Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex. | Journal of medicinal chemistry 20090827 |
| The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. | The Journal of biological chemistry 20090102 |
| Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. | The Journal of physiology 20080101 |
| Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo. | Neuroscience research 20061101 |
| Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms. | Brain research 20050628 |
| D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8. | Neuroscience letters 20050429 |
| Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists. | Journal of neuroscience research 20050301 |
| Putative NMDA receptors in Hydra: a biochemical and functional study. | The European journal of neuroscience 20041101 |
| Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. | FEBS letters 20040521 |
| 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. | Bioorganic & medicinal chemistry letters 20040503 |
| Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands. | Journal of structural biology 20040301 |
| Selective antagonism of rat inhibitory glycine receptor subunits. | The Journal of physiology 20040201 |
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. | Journal of medicinal chemistry 20040101 |
| Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors. | European journal of pharmacology 20030822 |
| Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids. | Journal of medicinal chemistry 20030703 |
| Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. | The EMBO journal 20030616 |
| Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site. | Journal of neurovirology 20030601 |
| Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. | Bioorganic & medicinal chemistry 20030417 |
| Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists. | Bioorganic & medicinal chemistry letters 20030210 |
| Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. | Neurochemistry international 20030101 |
| In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site. | Brain research 20020719 |
| Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney. | Journal of the American Society of Nephrology : JASN 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. | The Journal of biological chemistry 20011130 |
| Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. | British journal of pharmacology 20011101 |
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. | Journal of medicinal chemistry 20010913 |
| Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. | Brain research 20010105 |
| Attenuation of morphine dependence and withdrawal by glycine B site antagonists in rats. | Pharmacology, biochemistry, and behavior 20010101 |
| Conjugation with L-Glutamate for in vivo brain drug delivery. | Journal of drug targeting 20010101 |
| Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts of the striatum to the regulation of muscle tone in rats. | Brain research 19980518 |
| The role of striatal glutamate receptors in models of Parkinson's disease. | Amino acids 19980101 |
| Antagonism of convulsions but failure to enhance GABA(A) receptor function by felbamate in mice tolerant to diazepam. | Neurochemical research 19970601 |
| Anticonvulsant activity of 5,7DCKA, NBQX, and felbamate against some chemoconvulsants in DBA/2 mice. | Pharmacology, biochemistry, and behavior 19961001 |
| Excitoprotective effect of felbamate in cultured cortical neurons. | Brain research 19951224 |
| Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. | European journal of pharmacology 19940901 |
| Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists. | Polish journal of pharmacology 19940101 |
| Yohimbine-induced seizures involve NMDA and GABAergic transmission. | Neuropharmacology 19920401 |