LPS activates ADAM9 dependent shedding of ACE from endothelial cells.

Biochemical and biophysical research communications 20120427

Log-scale dose response of inhibitors on a chip.

Analytical chemistry 20110815

Mammalian EGF receptor activation by the rhomboid protease RHBDL2.

EMBO reports 20110501

Proteomics of wound exudate in snake venom-induced pathology: search for biomarkers to assess tissue damage and therapeutic success.

Journal of proteome research 20110401

Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice.

Arteriosclerosis, thrombosis, and vascular biology 20101201

GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.

Cancer science 20101101

MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis.

Cardiovascular research 20100701

Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice.

The American journal of pathology 20100701

Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.

Journal of neuroscience research 20100301

[Protective role of MMP-9 inhibitor batimastat in acute lung injury after cardiopulmonary bypass].

Zhonghua wai ke za zhi [Chinese journal of surgery] 20100101

Matrix metalloproteinase inhibition delays wound healing and blocks the latent transforming growth factor-beta1-promoted myofibroblast formation and function.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20100101

Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity.

Genes to cells : devoted to molecular & cellular mechanisms 20090501

Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells.

Journal of periodontal research 20090401

TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia.

Experimental neurology 20090301

MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.

American journal of physiology. Lung cellular and molecular physiology 20090201

Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis.

Surgery 20090201

Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.

Journal of immunology (Baltimore, Md. : 1950) 20090101

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.

Cancer research 20080815

Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines.

British journal of haematology 20080701

Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080401

Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.

Annals of the rheumatic diseases 20080101

Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions.

Cancer research 20071215

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice.

Molecular cancer therapeutics 20070901

MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.

Free radical biology & medicine 20070701

Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.

Journal of cell science 20070501

Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat.

Virchows Archiv : an international journal of pathology 20070301

Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.

Experimental hematology 20070301

Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.

Brain research 20070216

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex.

Archives of biochemistry and biophysics 20070101

Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.

Journal of immunology (Baltimore, Md. : 1950) 20061115

Effects of an inhibitor of alpha-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats.

Neuroscience and behavioral physiology 20061101

EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma.

The Journal of surgical research 20060901

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.

Laboratory investigation; a journal of technical methods and pathology 20060901

Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.

European journal of pharmacology 20060807

Neuregulin isoforms in dorsal root ganglion neurons: effects of the cytoplasmic domain on localization and membrane shedding of Nrg-1 type I.

Journal of neuroscience research 20060701

N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.

Bioorganic & medicinal chemistry letters 20060101

Neutrophil activator of matrix metalloproteinase-2 (NAM).

Clinical & experimental metastasis 20060101

Is the excessive inhibition of matrix metalloproteinases (MMPs) by potent synthetic MMP inhibitors (MMPIs) desirable in periodontitis and other inflammatory diseases? That is: 'Leaky' MMPIs vs excessively efficient drugs.

Oral diseases 20051101

Matrix metalloproteinases in endometrial breakdown and repair: functional significance in a mouse model.

Biology of reproduction 20051001

MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9.

Cardiovascular research 20050501

Protease inhibitor treatments reveal specific involvement of matrix metalloproteinase-9 in human adipocyte differentiation.

The Journal of pharmacology and experimental therapeutics 20050301

[Batimastat-eluting stent implantation for the treatment of coronary artery disease: results of the Brazilian pilot study].

Arquivos brasileiros de cardiologia 20050301

Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.

Journal of cellular biochemistry 20050215

Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP.

Journal of cell science 20050115

N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity.

Bioorganic & medicinal chemistry letters 20050103

Cleavage of apolipoprotein E by membrane-type matrix metalloproteinase-1 abrogates suppression of cell proliferation.

Journal of biochemistry 20050101

[Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20050101

Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy.

Clinical cancer research : an official journal of the American Association for Cancer Research 20041201

Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.

Molecular endocrinology (Baltimore, Md.) 20041101

Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.

The Journal of biological chemistry 20041029

Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.

The Journal of biological chemistry 20041015

Opioid control of MAP kinase cascade.

European journal of pharmacology 20041001

Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.

Circulation 20040803

Influence of the matrix metalloproteinase inhibitor batimastat (BB-94) on periodontal bone destruction in Sprague-Dawley rats.

Journal of periodontal research 20040801

Chemically modified tetracyclines act through multiple mechanisms directly on osteoclast precursors.

Bone 20040801

Growth factors improve the in vivo migration of human skeletal myoblasts by modulating their endogenous proteolytic activity.

Transplantation 20040615

Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor.

Clinical cancer research : an official journal of the American Association for Cancer Research 20040615

Effect of metalloprotease inhibitors on corneal allograft survival.

Investigative ophthalmology & visual science 20040401

Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.

Journal of cell science 20040401

Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.

Toxicon : official journal of the International Society on Toxinology 20040315

Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt.

The Journal of biological chemistry 20040227

Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features.

Journal of molecular biology 20040206

Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121

Comparison of expression of cathepsins B and L and MMP2 in endothelial cells and in capillary sprouting in collagen gel.

The International journal of biological markers 20040101

Drug loading and elution from a phosphorylcholine polymer-coated coronary stent does not affect long-term stability of the coating in vivo.

Bio-medical materials and engineering 20040101

A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.

Tuberculosis (Edinburgh, Scotland) 20040101

[Expression of matrix metalloproteinases in patients with malignant tumors].

Medicina (Kaunas, Lithuania) 20040101

Ultrastructural localization of spicule matrix proteins in normal and metalloproteinase inhibitor-treated sea urchin primary mesenchyme cells.

Journal of experimental zoology. Part A, Comparative experimental biology 20031201

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.

Toxicology and applied pharmacology 20031115

Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.

International immunopharmacology 20031101

Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase.

International journal of cancer 20030901

Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis.

The European journal of neuroscience 20030901

Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation.

Cancer research 20030901

[Effect of batimastat on the dynamic changes of matrix metalloproteinases in liver tissue during the development of hepatocellular carcinoma in rats].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20030901

Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion.

Stroke 20030801

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

Journal of medicinal chemistry 20030731

Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation.

Biochimica et biophysica acta 20030721

Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats.

American journal of physiology. Lung cellular and molecular physiology 20030701

Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.

The Journal of biological chemistry 20030404

Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.

Blood 20030301

Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro.

Investigative ophthalmology & visual science 20030301

[Angiogenesis research--quo vadis?].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030201

The G1 domain of aggrecan released from porcine articular cartilage forms stable complexes with hyaluronan/link protein.

Rheumatology (Oxford, England) 20030201

Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20030201

Inhibition of matrix metalloproteinases reduces local and distant organ injury following experimental acute pancreatitis.

The Journal of surgical research 20030201

Downregulation of caspases and Fas ligand expression, and increased lifespan of neutrophils after transmigration across intestinal epithelium.

Cell death and differentiation 20030201

[Matrix metalloproteinases and atherosclerosis. Therapeutic aspects].

Annales de biologie clinique 20030101

Differential expression of MMP-2/MMP-9 and potential benefit of an MMP inhibitor in experimental acute kidney allograft rejection.

Transplant immunology 20030101

Metalloproteinase inhibition by batimastat does not reduce neointimal thickening in stented atherosclerotic porcine femoral arteries.

Cardiovascular radiation medicine 20030101

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process.

Journal of immunology (Baltimore, Md. : 1950) 20021201

MMP inhibition and the development of cerebrovascular atherosclerosis: The road ahead.

Stroke 20021201

Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration.

The Journal of biological chemistry 20021018

Active matrix metalloprotease-9 in and migration pattern of dendritic cells matured in clinical grade culture conditions.

Immunobiology 20021001

Metalloproteases and guidance of retinal axons in the developing visual system.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020915

The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat.

International journal of colorectal disease 20020901

Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade.

Atherosclerosis 20020801

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

Journal of neurochemistry 20020801

Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1.

Kidney international 20020701

Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20020701

Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

Stromelysin-1 activation correlates with invasiveness in squamous cell carcinoma.

The Journal of investigative dermatology 20020501

Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.

FEBS letters 20020424

Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.

Mediators of inflammation 20020401

Ligand-induced shedding of discoidin domain receptor 1.

FEBS letters 20020313

MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure.

American journal of physiology. Heart and circulatory physiology 20020301

Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats.

Stroke 20020301

Regulation of galectin-9 expression and release in Jurkat T cell line cells.

Glycobiology 20020201

Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.

International journal of cancer 20020120

Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid.

Biochemical pharmacology 20020115

Prostate cancer in bone: importance of context for inhibition of matrix metalloproteinases.

Journal of the National Cancer Institute 20020102

Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.

Journal of the National Cancer Institute 20020102

Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat.

Gastroenterology 20020101

Thermolysin activates equine lamellar hoof matrix metalloproteinases.

Journal of comparative pathology 20020101

Hyperthermia exhibits anti-vascular activity in the s.c. BT4An rat glioma: lack of interaction with the angiogenesis inhibitor batimastat.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101

The metalloprotease-directed shedding of BP 180 (collagen XVII) from human keratinocytes in culture is unaffected by ceramide and cell-matrix interaction.

European journal of dermatology : EJD 20020101

Perioperative matrix metalloproteinase inhibition therapy does not impair wound or anastomotic healing.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20020101

The matrix metalloproteinase inhibitor batimastat inhibits the lung colonisation of orthotopically implanted malignant pancreatic tumor cells in SCID mice.

Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera 20020101

Combining antiangiogenic agents with metronomic chemotherapy enhances efficacy against late-stage pancreatic islet carcinomas in mice.

Cold Spring Harbor symposia on quantitative biology 20020101

Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.

The Journal of biological chemistry 20011214

Potentiation of docetaxel antitumor activity by batimastat against mouse forestomach carcinoma.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20011201

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.

Nature medicine 20011101

Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.

Journal of molecular biology 20010928

Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901

Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation.

Diabetes 20010901

Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways.

Arthritis and rheumatism 20010901

Quantitation of cell migration in a rat carotid artery balloon injury model. Indications for a perivascular origin of the neointimal cells.

Cardiovascular drugs and therapy 20010901

Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice.

European journal of pharmacology 20010824

Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesis.

Circulation research 20010803

Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.

Breast cancer research and treatment 20010801

Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition.

Circulation 20010703

Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development.

Journal of cellular physiology 20010701

[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20010701

A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.

The Journal of biological chemistry 20010615

Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.

Cancer research 20010615

Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices.

Blood 20010515

In vitro evidence for a bacterial pathogenesis of equine laminitis.

Veterinary microbiology 20010402

uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration.

Experimental cell research 20010401

Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat.

The Journal of pathology 20010401

Validation of an orthotopic model of human lung cancer with regional and systemic metastases.

The Annals of thoracic surgery 20010401

Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury.

The Journal of biological chemistry 20010330

A possible role for metalloproteinases in renal cyst development.

American journal of physiology. Renal physiology 20010301

Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

Cancer research 20010215

Development of matrix metalloproteinase inhibitors in cancer therapy.

Journal of the National Cancer Institute 20010207

HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors.

Annals of neurology 20010201

Renal matrix metalloproteinase activity is unaffected by experimental ischemia-reperfusion injury and matrix metalloproteinase inhibition does not alter outcome of renal function.

Experimental nephrology 20010101

A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by MDA-MB-231 human breast cancer cells in Balb C nu/nu mice.

European journal of cancer (Oxford, England : 1990) 20010101

Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis.

Digestion 20010101

Matrix metalloproteinases in the progression of heart failure: potential therapeutic implications.

Drugs 20010101

An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay.

Angiogenesis 20010101

Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.

The Journal of biological chemistry 19980807