Home Halogens Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

CAS No.:
13010-47-4
Catalog Number:
AG000U0T
Molecular Formula:
C9H16ClN3O2
Molecular Weight:
233.6952
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%(HPLC)
In Stock USA
United States
$46
- +
25mg
95%(HPLC)
In Stock USA
United States
$68
- +
100mg
95%(HPLC)
In Stock USA
United States
$135
- +
250mg
95%(HPLC)
In Stock USA
United States
$250
- +
1g
95%(HPLC)
In Stock USA
United States
$597
- +
Product Description
Catalog Number:
AG000U0T
Chemical Name:
Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
CAS Number:
13010-47-4
Molecular Formula:
C9H16ClN3O2
Molecular Weight:
233.6952
MDL Number:
MFCD00012392
IUPAC Name:
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
InChI:
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChI Key:
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
SMILES:
ClCCN(C(=O)NC1CCCCC1)N=O
EC Number:
235-859-2
UNII:
7BRF0Z81KG
Properties
Complexity:
219  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
233.093g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
233.696g/mol
Monoisotopic Mass:
233.093g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
61.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. Toxicology and applied pharmacology 20170301
High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Archives of toxicology 20170101
Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance. Cancer research 20141001
The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response. Toxicological sciences : an official journal of the Society of Toxicology 20140701
Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology 20140106
Tolerability of lomustine in combination with cyclophosphamide in dogs with lymphoma. Journal of the American Animal Hospital Association 20140101
Phase II clinical evaluation of lomustine chemotherapy for feline vaccine-associated sarcoma. Veterinary and comparative oncology 20121201
Chemotherapy in low-grade gliomas. Current opinion in oncology 20121101
Evaluation of lomustine as a rescue agent for cats with resistant lymphoma. Journal of feline medicine and surgery 20121001
Cervicothoracic syringohydromyelia associated with a prosencephalic mass in a dog. The Journal of small animal practice 20121001
Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120910
Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. Veterinary clinical pathology 20120901
Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120901
Chemotherapy dose-intensity and survival for childhood medulloblastoma. Anticancer research 20120901
Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720
Late and prolonged pseudoprogression in glioblastoma after treatment with lomustine and temozolomide. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720
Initial treatment patterns over time for anaplastic oligodendroglial tumors. Neuro-oncology 20120601
Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma. Journal of neuro-oncology 20120501
Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study. Journal of neuro-oncology 20120501
Autologous noncryopreserved hematopoietic stem cell transplant with CEAM as a modified conditioning regimen in patients with Hodgkin lymphoma: a single-center experience with a new protocol. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20120401
The role of chemotherapy in anaplastic astrocytoma patients. Journal of Korean Neurosurgical Society 20120401
Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial. Leukemia & lymphoma 20120301
Extraneural metastasis of glioblastoma multiforme presenting as an unusual neck mass. Journal of Korean Neurosurgical Society 20120301
Meta-analysis of phase III trials of docetaxel alone or in combination with chemotherapy in metastatic breast cancer. Journal of cancer research and clinical oncology 20120201
[Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab]. Bulletin du cancer 20120201
Prophylactic intrathecal chemotherapy in primary CNS lymphoma. Journal of neuro-oncology 20120101
Antiangiogenic therapy for patients with recurrent and newly diagnosed malignant gliomas. Journal of oncology 20120101
Modulation of pediatric brain tumor autophagy and chemosensitivity. Journal of neuro-oncology 20120101
Anaplastic atypical myeloma with extensive cutaneous involvement in a dog. The Journal of veterinary medical science 20120101
Prediction of glioblastoma multiform response to bevacizumab treatment using multi-parametric MRI. PloS one 20120101
Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures. World journal of surgical oncology 20120101
Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses. Scientific reports 20120101
A randomized trial investigating the efficacy and safety of water soluble micellar paclitaxel (Paccal Vet) for treatment of nonresectable grade 2 or 3 mast cell tumors in dogs. Journal of veterinary internal medicine 20120101
MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR. Journal of translational medicine 20120101
Iodine-125 brachytherapy for brain tumours--a review. Radiation oncology (London, England) 20120101
Detection of 1p19q deletion by real-time comparative quantitative PCR. Biomarker insights 20120101
Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients. PloS one 20120101
Inhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines. PloS one 20120101
Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme. PloS one 20120101
Subgroup economic analysis for glioblastoma in a health resource-limited setting. PloS one 20120101
Current trends in targeted therapies for glioblastoma multiforme. Neurology research international 20120101
Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings. Advances in hematology 20120101
Long-term survival after gamma knife radiosurgery in a case of recurrent glioblastoma multiforme: a case report and review of the literature. Case reports in medicine 20120101
Current and emerging pharmacotherapies for primary CNS lymphoma. Clinical Medicine Insights. Oncology 20120101
Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells. PloS one 20120101
Therapeutic strategies based on polymeric microparticles. Journal of biomedicine & biotechnology 20120101
An unusual presentation of tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: case report and literature review. Case reports in medicine 20120101
The Risk of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia in Hodgkin Lymphoma has Substantially Decreased in the ABVD Era Abolishing Mechlorethamine and Procarbazine and Limiting Volumes and Doses of Radiotherapy. Mediterranean journal of hematology and infectious diseases 20120101
[Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1]. Voprosy onkologii 20120101
Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas. European journal of haematology 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Long-term follow-up analysis of HD9601 trial comparing ABVD versus Stanford V versus MOPP/EBV/CAD in patients with newly diagnosed advanced-stage Hodgkin's lymphoma: a study from the Intergruppo Italiano Linfomi. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111110
Lecture: fotemustine in brain tumors. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience. Oncotarget 20111101
Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials. Journal of the National Cancer Institute 20111019
Chemotherapy for diffuse low-grade gliomas in adults. Revue neurologique 20111001
Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma. Clinics (Sao Paulo, Brazil) 20111001
Immunochemotherapy with rituximab, methotrexate, procarbazine, and lomustine for primary CNS lymphoma (PCNSL) in the elderly. Annals of oncology : official journal of the European Society for Medical Oncology 20110901
Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group. Annals of oncology : official journal of the European Society for Medical Oncology 20110901
Leptomeningeal disease in oligodendroglial tumors: a population-based study. Journal of neuro-oncology 20110901
Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review. Journal of neuro-oncology 20110901
NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri. Annals of neurology 20110901
Diencephalic tumors in children: a 30-year experience of a single institution. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110801
High-grade gliomas. Current treatment options in neurology 20110801
Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas. Pediatric blood & cancer 20110715
Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009). Journal of the American Veterinary Medical Association 20110715
Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951. Cancer 20110701
Glioblastoma: patterns of recurrence and efficacy of salvage treatments. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701
Implementation of neuro-oncology service reconfiguration in accordance with NICE guidance provides enhanced clinical care for patients with glioblastoma multiforme. British journal of cancer 20110607
LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre. Hematological oncology 20110601
Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951. Journal of neuro-oncology 20110601
HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats. European journal of drug metabolism and pharmacokinetics 20110601
International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors. Neuro-oncology 20110601
High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D pilot study. Journal of neuro-oncology 20110501
Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma. Journal of neuro-oncology 20110501
Treatment of follicular non-Hodgkin's lymphoma with or without rituximab: cost-effectiveness and value of information based on a 5-year follow-up. Annals of oncology : official journal of the European Society for Medical Oncology 20110501
Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15. Anticancer research 20110501
Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma. Journal of neuro-oncology 20110401
CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07). Australian veterinary journal 20110401
Identification of diagnostic serum protein profiles of glioblastoma patients. Journal of neuro-oncology 20110301
Short topotecan-based induction regimen in newly diagnosed high-risk neuroblastoma. European journal of cancer (Oxford, England : 1990) 20110301
Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study. Acta neurochirurgica 20110301
A network meta-analysis of randomized controlled trials of induction treatments in acute myeloid leukemia in the elderly. Clinical therapeutics 20110301
MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation. Journal of neuro-oncology 20110201
Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs. Journal of the American Veterinary Medical Association 20110201
A stability-indicating liquid chromatographic method for Lomustine. Journal of pharmaceutical and biomedical analysis 20110105
Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110101
Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro-oncology 20110101
Systematic review of medical treatment in melanoma: current status and future prospects. The oncologist 20110101
Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches. Radiation oncology (London, England) 20110101
A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples. BMC medical genomics 20110101
Tolerability of metronomic administration of lomustine in dogs with cancer. Journal of veterinary internal medicine 20110101
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PloS one 20110101
Lomustine loaded chitosan nanoparticles: characterization and in-vitro cytotoxicity on human lung cancer cell line L132. Chemical & pharmaceutical bulletin 20110101
The use of lithium carbonate to prevent lomustine-induced myelosuppression in dogs: a pilot study. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20110101
[Cellular markers based on DNA damage and repair (BER, MMR), expression of MLHI, MSH2, FasR, and cell death of lymphocytes as predictive parameters for clinical response to chemotherapy of melanoma]. Tsitologiia 20110101
Achievement of three year remission with bevacizumab and irinotecan in recurrent glioblastoma multiforme: a case report. Clinical Medicine Insights. Oncology 20110101
Long-term survival with primary glioblastoma multiforme: a clinical study in bulgarian patients. Case reports in oncology 20110101
High-dose chemotherapy with autologous hematopoietic stem-cell rescue for pediatric brain tumor patients: a single institution experience from UCLA. Journal of transplantation 20110101
The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II. International journal of molecular imaging 20110101
Bevacizumab for the treatment of recurrent glioblastoma. Clinical Medicine Insights. Oncology 20110101
Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma. Advances in hematology 20110101
The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future. Advances in hematology 20110101
Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs. Journal of veterinary internal medicine 20110101
Treatment of HIV-related primary central nervous system lymphoma with AZT high dose, HAART, interleukin-2 and foscarnet in three patients. European journal of medical research 20110101
Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. PloS one 20110101
Uveal melanoma. Journal of skin cancer 20110101
[Effectiveness of DNA repair and expression of MLH1, MSH2 and FASR in lymphocytes of patients with chemotherapy-responsive, disseminated cutaneous melanoma]. Voprosy onkologii 20110101
[Investigation of gemcitabine plus lomustine treatment in mice with transplantable lymphosarcoma LIO-1]. Voprosy onkologii 20110101
Nitrosourea chemotherapeutic agents: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea. Report on carcinogens : carcinogen profiles 20110101
Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back? Radiation oncology (London, England) 20110101
Chemoresistance of glioblastoma cancer stem cells--much more complex than expected. Molecular cancer 20110101
Long survival of primary diffuse leptomeningeal gliomatosis following radiotherapy and temozolomide: case report and literature review. European journal of medical research 20110101
Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells. BMC cancer 20110101
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. PloS one 20110101
Innovative Therapies against Human Glioblastoma Multiforme. ISRN oncology 20110101
Selective internal radiation therapy for gastrointestinal neuroendocrine tumour liver metastases: a new and effective modality for treatment. International journal of hepatology 20110101
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clinical & developmental immunology 20110101
[Brain metastasis in breast cancer]. Voprosy onkologii 20110101
New agents targeting angiogenesis in glioblastoma. Chemotherapy research and practice 20110101
Bevacizumab improves quality of life in patients with recurrent glioblastoma. Chemotherapy research and practice 20110101
Radiation Dose Escalation in Stage III Non-Small-Cell Lung Cancer. Frontiers in oncology 20110101
Combined modality approaches in the management of adult glioblastoma. Frontiers in oncology 20110101
Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs. Veterinary and comparative oncology 20101201
KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. Brain pathology (Zurich, Switzerland) 20101101
Molecular diagnostics of gliomas: state of the art. Acta neuropathologica 20101101
Chemotherapy: Lo and behold, a role for lomustine in acute myeloid leukemia? Nature reviews. Clinical oncology 20101101
Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101020
Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update. Journal of neuro-oncology 20101001
Prolonged response without prolonged chemotherapy: a lesson from PCV chemotherapy in low-grade gliomas. Neuro-oncology 20101001
First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience. Neurosurgical review 20101001
Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules. British journal of cancer 20100907
Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective. Acta neuropathologica 20100901
Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours. Veterinary and comparative oncology 20100901
Glioblastoma multiforme in childhood: a case report. Clinics (Sao Paulo, Brazil) 20100901
Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib. Journal of neuro-oncology 20100801
Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall. Acta neuropathologica 20100801
Cognition and quality of life after chemotherapy plus radiotherapy (RT) vs. RT for pure and mixed anaplastic oligodendrogliomas: radiation therapy oncology group trial 9402. International journal of radiation oncology, biology, physics 20100701
Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort. Journal of neuro-oncology 20100701
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 20100701
Recurrent high-grade glioma. Current treatment options in neurology 20100701
Addition of lomustine to idarubicin and cytarabine improves the outcome of elderly patients with de novo acute myeloid leukemia: a report from the GOELAMS. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100620
Canine cutaneous epitheliotropic T-cell lymphoma: a review of 30 cases. Veterinary dermatology 20100601
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 20100601
A phase II study to evaluate the toxicity and efficacy of alternating CCNU and high-dose vinblastine and prednisone (CVP) for treatment of dogs with high-grade, metastatic or nonresectable mast cell tumours. Veterinary and comparative oncology 20100601
Vincristine in high-grade glioma. Anticancer research 20100601
The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing. Toxicology letters 20100504
Management of low-grade glioma. Current neurology and neuroscience reports 20100501
Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data. Lancet (London, England) 20100410
Apparent feline leukemia virus-induced chronic lymphocytic leukemia and response to treatment. Journal of feline medicine and surgery 20100401
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100301
IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Clinical cancer research : an official journal of the American Association for Cancer Research 20100301
Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice. Neuro-oncology 20100301
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. Bioorganic & medicinal chemistry 20100301
Oral second- and third-line lomustine-etoposide-cyclophosphamide chemotherapy for small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 20100201
Extended-schedule dose-dense temozolomide in refractory gliomas. Journal of neuro-oncology 20100201
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control. Annals of oncology : official journal of the European Society for Medical Oncology 20100201
Protein tyrosine phosphatases in glioma biology. Acta neuropathologica 20100201
Bevacizumab is active as a single agent against recurrent malignant gliomas. Anticancer research 20100201
Effectiveness of temozolomide for primary glioblastoma multiforme in routine clinical practice. Journal of neuro-oncology 20100101
The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. Journal of neuro-oncology 20100101
Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study. Neurosurgery 20100101
Progress on antiangiogenic therapy for patients with malignant glioma. Journal of oncology 20100101
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC cancer 20100101
CyberKnife enhanced conventionally fractionated chemoradiation for high grade glioma in close proximity to critical structures. Journal of hematology & oncology 20100101
Health-related quality of life in glioma patients in China. BMC cancer 20100101
Mesenchymal migration as a therapeutic target in glioblastoma. Journal of oncology 20100101
Impact of adjuvant chemotherapy for gliomatosis cerebri. BMC cancer 20100101
Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept. BMC cancer 20100101
I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma. Molecular cancer 20100101
The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC cancer 20100101
Temozolomide in malignant glioma. OncoTargets and therapy 20100101
Malignant head and neck paragangliomas: is there an optimal treatment strategy? Head & neck oncology 20100101
Conversion of a molecular classifier obtained by gene expression profiling into a classifier based on real-time PCR: a prognosis predictor for gliomas. BMC medical genomics 20100101
High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study. Journal of translational medicine 20100101
Late onset of cerebellar abiotrophy in a boxer dog. Veterinary medicine international 20100101
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. Journal of veterinary internal medicine 20100101
Natural history and outcome of optic pathway gliomas in children. Pediatric blood & cancer 20091215
De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system. Pediatric blood & cancer 20091215
Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. British journal of cancer 20091215
Anaplastic glioma: how to prognosticate outcome and choose a treatment strategy. [corrected]. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210
Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951. Neuro-oncology 20091201
Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)*. Veterinary and comparative oncology 20091201
Current data and strategy in glioblastoma multiforme. Journal of medicine and life 20091115
Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology 20091109
Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse. Journal of neuro-oncology 20091001
Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Cancer chemotherapy and pharmacology 20090901
Combined radio- and chemotherapy of brain tumours in adult patients. Clinical oncology (Royal College of Radiologists (Great Britain)) 20090901
Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases. Veterinary and comparative oncology 20090901
[A multicenter randomized controlled study of temozolomide in 97 patients with malignant brain glioma]. Zhonghua yi xue za zhi 20090804
Low-grade gliomas. Current treatment options in oncology 20090801
Immunotherapy of distant metastatic disease. Annals of oncology : official journal of the European Society for Medical Oncology 20090801
Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090720
Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation? Pediatric blood & cancer 20090701
[Clinicopathological diagnosis of gliomas by genotype analysis]. Brain and nerve = Shinkei kenkyu no shinpo 20090701
[Treatment of glioma with temozolomide]. Brain and nerve = Shinkei kenkyu no shinpo 20090701
Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090601
Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy. Veterinary and comparative oncology 20090601
Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat. The Journal of veterinary medical science 20090601
Molecular markers of tumor progression in melanoma. Current genomics 20090601
Bevacizumab for recurrent alkylator-refractory anaplastic oligodendroglioma. Cancer 20090415
Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310
ACNU-based chemotherapy for recurrent glioma in the temozolomide era. Journal of neuro-oncology 20090301
Canine cutaneous epitheliotropic T-cell lymphoma: a review. Veterinary and comparative oncology 20090301
Evaluation of dexamethasone as a chemoprotectant for CCNU-induced bone marrow suppression in dogs. Veterinary and comparative oncology 20090301
ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090210
High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study. Annals of oncology : official journal of the European Society for Medical Oncology 20090201
Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics. Chemical communications (Cambridge, England) 20090107
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma. Journal of neuro-oncology 20090101
Increased degradation rate of nitrososureas in media containing carbonate. In vitro cellular & developmental biology. Animal 20090101
Long-term progression-free survival in metastatic uveal melanoma after chemoimmunotherapy and consolidation thermoablation. Acta oncologica (Stockholm, Sweden) 20090101
Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors. Journal of the American Animal Hospital Association 20090101
Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs. Journal of veterinary internal medicine 20090101
Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells. Journal of translational medicine 20090101
Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. PloS one 20090101
Molecular neuropathology of gliomas. International journal of molecular sciences 20090101
Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation. BMC cancer 20090101
High specificity of quantitative methylation-specific PCR analysis for MGMT promoter hypermethylation detection in gliomas. Journal of biomedicine & biotechnology 20090101
Primary non-Hodgkin's lymphoma of the infratemporal fossa: a rare case report. Head & neck oncology 20090101
Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors. BMC neurology 20090101
A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China. Journal of hematology & oncology 20090101
Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed canine lymphoma. Journal of veterinary internal medicine 20090101
Current available therapies and future directions in the treatment of malignant gliomas. Biologics : targets & therapy 20090101
Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier: relationship between structure, blood clearance, and MRI signal dynamic in the brain. Molecular pharmaceutics 20090101
Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors. Journal of translational medicine 20090101
RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study. BMC cancer 20090101
Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains. BMC microbiology 20090101
Dose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91. Klinische Padiatrie 20090101
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. PloS one 20090101
Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy. BMC cancer 20090101
Synthesis of trans- and cis-4'-hydroxylomustine and development of validated analytical method for lomustine and trans- and cis-4'-hydroxylomustine in canine plasma. Journal of analytical toxicology 20090101
Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma. Case reports in medicine 20090101
Antiangiogenic therapy in the treatment of recurrent medulloblastoma in the adult: case report and review of the literature. Journal of oncology 20090101
Rational use of cetuximab in the treatment of advanced non-small cell lung cancer. OncoTargets and therapy 20090101
Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas. Core evidence 20090101
New therapies for recurrent glioblastomas. F1000 medicine reports 20090101
Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations. Cancer management and research 20090101
Rates of inclusion of teenagers and young adults in England into National Cancer Research Network clinical trials: report from the National Cancer Research Institute (NCRI) Teenage and Young Adult Clinical Studies Development Group. British journal of cancer 20081209
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
Survival from brain tumours in England and Wales up to 2001. British journal of cancer 20080923
A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis. Journal of neuro-oncology 20080901
Treatment of Hodgkin lymphoma: the past, present, and future. Nature clinical practice. Oncology 20080901
Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy. Annals of oncology : official journal of the European Society for Medical Oncology 20080901
Chemotherapy and radiotherapy for treatment of cutaneous lymphoma in a ground cuscus (Phalanger gymnotis). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080901
Cryptococcal meningitis in patients with glioma: a report of two cases. Journal of neuro-oncology 20080801
A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood. Neuro-oncology 20080801
In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. British journal of cancer 20080722
Anaplastic oligodendroglioma. Current treatment options in neurology 20080701
Lessons from a time capsule: evolution, not revolution, in therapy for advanced non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080701
Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells. Cancer research 20080701
Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study. British journal of cancer 20080603
Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat. Veterinary and comparative oncology 20080601
[Chemotherapy and renal toxicity]. Bulletin du cancer 20080528
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients. Journal of neuro-oncology 20080501
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas. The Cochrane database of systematic reviews 20080416
High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system. Cancer 20080415
Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005). Journal of the American Veterinary Medical Association 20080415
Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells. Journal of neuro-oncology 20080401
Influence of therapy on the antioxidant status in patients with melanoma. Journal of clinical pharmacy and therapeutics 20080401
Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides. Biochemical and biophysical research communications 20080227
A long-term durable remission with high-dose therapy and autologous stem cell transplant for stage IVB HIV-associated Hodgkins disease. AIDS (London, England) 20080219
A phase II study investigating the re-induction of endocrine sensitivity following chemotherapy in androgen-independent prostate cancer. British journal of cancer 20080115
Re-induction of hormone sensitivity to diethylstilboestrol in androgen refractory prostate cancer patients following chemotherapy. British journal of cancer 20080115
Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy. Oral oncology 20080101
Complete response after treatment with a somatostatin analogue in an adult patient with recurrent medulloblastoma. Acta oncologica (Stockholm, Sweden) 20080101
Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma. Neuro-oncology 20080101
Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs. Journal of veterinary internal medicine 20080101
Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling. Cancer cell international 20080101
Consultation within the nephroblastoma trial SIOP 2001/GPOH as part of the workload in the trial office. Klinische Padiatrie 20080101
Procarbazine--a traditional drug in the treatment of malignant gliomas. Current medicinal chemistry 20080101
Clinicopathological features and outcome for dogs with mast cell tumors and bone marrow involvement. Journal of veterinary internal medicine 20080101
Procarbazine and CCNU as initial treatment in gliomatosis cerebri. Oncology 20080101
Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC medical genomics 20080101
[Postoperative chemoradiotherapy for cerebral glioblastoma]. Voprosy onkologii 20080101
[Clinical features and combined treatment of the central nervous system in Hodgkin's disease]. Voprosy onkologii 20080101
Reinduction of bevacizumab in combination with pegylated liposomal Doxorubicin in a patient with recurrent glioblastoma multiforme who progressed on bevacizumab/irinotecan. Journal of oncology 20080101
A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma. Clinical medicine. Oncology 20080101
Health-related quality of life in patients treated for anaplastic oligodendroglioma with adjuvant chemotherapy: results of a European Organisation for Research and Treatment of Cancer randomized clinical trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071220
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer research 20071215
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance. British journal of pharmacology 20071201
Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide. Therapeutics and clinical risk management 20071201
Diffuse glioma growth: a guerilla war. Acta neuropathologica 20071101
Molecular targeted therapies and chemotherapy in malignant gliomas. Current opinion in oncology 20071101
Anaplastic oligodendroglioma and oligoastrocytoma. Neurologic clinics 20071101
Adjuvant chemotherapy for adults with malignant glioma: a systematic review. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20071101
Adding lomustine to idarubicin and cytarabine for induction chemotherapy in older patients with acute myeloid leukemia: the BGMT 95 trial results. Haematologica 20071001
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. Therapeutics and clinical risk management 20071001
Chemoradiotherapy in malignant glioma: standard of care and future directions. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070910
A phase 2 feasibility study of sequential, dose intensive chemotherapy to treat progressive low-grade gliomas in children. Journal of pediatric hematology/oncology 20070901
Successful treatment with voriconazole of Aspergillus brain abscess in a boy with medulloblastoma. Pediatric blood & cancer 20070801
The 2007 WHO classification of tumours of the central nervous system. Acta neuropathologica 20070801
Effect of the spin-labelled 1-ethyl-1-nitrosourea on CCNU-induced oxidative liver injury. Die Pharmazie 20070801
Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). Journal of the American Veterinary Medical Association 20070615
Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutation research 20070601
Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma. Oncology reports 20070601
Canadian recommendations for the treatment of glioblastoma multiforme. Current oncology (Toronto, Ont.) 20070601
Treatment of malignant lymphoma in an African lion (Panthera leo). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20070601
Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Therapeutics and clinical risk management 20070601
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. Journal of neuro-oncology 20070501
[Randomised phase II study evaluating oral combination chemotherapy (CCNU, cyclophosphamide, etoposide) and intravenous chemotherapy as second-line treatment for relapsed small cell bronchial carcinoma (Trial GFPC0501)]. Revue des maladies respiratoires 20070501
The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute 20070418
Timing of radiation in children with medulloblastoma/PNET. Pediatric blood & cancer 20070401
Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy. European journal of neurology 20070401
Chemotherapy for relapsed small cell lung cancer: a systematic review and practice guideline. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070401
Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. British journal of cancer 20070326
Astrocytic tumors in children: treatment results from a single institution. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20070301
Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells. Acta neuropathologica 20070201
A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma. British journal of cancer 20070115
LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin's lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre. Bone marrow transplantation 20070101
CCNU for the treatment of dogs with histiocytic sarcoma. Journal of veterinary internal medicine 20070101
Combination chemotherapy with L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma. Journal of veterinary internal medicine 20070101
Serum VEGF-C is associated with metastatic site in patients with malignant melanoma. Acta oncologica (Stockholm, Sweden) 20070101
Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas. BMC cancer 20070101
Overexpressed TP73 induces apoptosis in medulloblastoma. BMC cancer 20070101
Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. Acta poloniae pharmaceutica 20070101
Radiotherapeutic alternatives for previously irradiated recurrent gliomas. BMC cancer 20070101
Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs. Cancer genomics & proteomics 20070101
Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma. Journal of translational medicine 20070101
Comparison of 3 protocols for treatment after induction of remission in dogs with lymphoma. Journal of veterinary internal medicine 20070101
DNA-metallodrugs interactions signaled by electrochemical biosensors: an overview. Bioinorganic chemistry and applications 20070101
[Clinical significance of mustoforan in management of malignant glioma]. Voprosy onkologii 20070101
[Analysis of selected undesirable effects of cytostatic drugs in treatment of the central nervous system tumours in children. Preliminary report]. Medycyna wieku rozwojowego 20070101
Targeted brain tumor treatment-current perspectives. Drug target insights 20070101
Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20061215
Effects of lipid association on lomustine (CCNU) administered intracerebrally to syngeneic 36B-10 rat brain tumors. Cancer letters 20061208
Late response to radiochemotherapy in pediatric glioblastoma: report on two patients treated according to HIT-GBM protocols. Pediatric hematology and oncology 20061201
New methods for direct delivery of chemotherapy for treating brain tumors. The Yale journal of biology and medicine 20061201
Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms. British journal of cancer 20061120
Chemotherapy for primary central nervous system lymphoma. Neurosurgical focus 20061115
[Long-term outcome in patients with symptomatic low-grade oligodendrogliomatous tumors treated by cytotoxic agents]. Revue neurologique 20061101
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. The Journal of veterinary medical science 20061101
[Small cell lung cancer (CPC). Second line treatment]. Revue des maladies respiratoires 20061101
Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas. British journal of cancer 20061023
Cerebral blood volume, genotype and chemosensitivity in oligodendroglial tumours. Neuroradiology 20061001
Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060920
A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. Cancer gene therapy 20060901
Phase II study of mitomycin-C, adriamycin, cisplatin (MAP) and Bleomycin-CCNU in patients with advanced cancer of the anal canal: An eastern cooperative oncology group study E7282. Investigational new drugs 20060901
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060901
Diagnosis and treatment of a feline oral mast cell tumor. Journal of feline medicine and surgery 20060801
Lomustine for the treatment of gastrointestinal mast cell tumour in a dog. The Journal of small animal practice 20060801
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. Neuro-oncology 20060701
Anaplastic oligodendroglial tumors: a tale of two trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620
Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620
Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors. Neurology 20060613
Gliomatosis cerebri treatment in 11 elderly patients. Journal of experimental & clinical cancer research : CR 20060601
Re-evaluation of the cost effectiveness of temozolomide for malignant gliomas in British Columbia. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601
[Palliative therapy in glioblastoma multiforme: a multimodal concept]. Wiener medizinische Wochenschrift (1946) 20060501
High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma: long-term follow-up. Neuro-oncology 20060401
Long-term chemotherapy with lomustine of intracranial meningioma occurring in a miniature schnauzer. The Journal of veterinary medical science 20060401
Mitoxantrone, vinblastine and CCNU: long-term follow-up of patients treated for advanced and poor-prognosis Hodgkin's disease. Leukemia & lymphoma 20060401
Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy. International journal of radiation oncology, biology, physics 20060315
Current strategies in treatment of oligodendroglioma: evolution of molecular signatures of response. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060310
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060301
PCV chemotherapy for recurrent glioblastoma. Neurology 20060227
Changing paradigms--an update on the multidisciplinary management of malignant glioma. The oncologist 20060201
Toxic epidermal necrolysis after PCV combination chemotherapy for relapsed B-cell lymphoma. Clinical oncology (Royal College of Radiologists (Great Britain)) 20060201
Oligodendroglial tumor chemotherapy using 'decreased-dose-intensity' PCV: a Singapore experience. Neurology 20060124
MOPPEBVCAD chemotherapy with limited and conditioned radiotherapy in advanced Hodgkin's lymphoma: 10-year results, late toxicity, and second tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20060115
Phase I study of temozolomide and lomustine in the treatment of high grade malignant glioma. Frontiers in bioscience : a journal and virtual library 20060101
CCNU in the treatment of canine epitheliotropic lymphoma. Journal of veterinary internal medicine 20060101
Solitary pulmonary metastasis from primary melanoma of the oesophagus 5 years after resection of the primary tumor. World journal of surgical oncology 20060101
Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC cancer 20060101
Treatments for astrocytic tumors in children: current and emerging strategies. Paediatric drugs 20060101
Hospital in the home (HITH) care following autologous stem cell transplantation for lymphoma and multiple myeloma. The Australian journal of advanced nursing : a quarterly publication of the Royal Australian Nursing Federation 20060101
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC cancer 20060101
CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of biology 20060101
Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999-2004). Journal of veterinary internal medicine 20060101
ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220
Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer 20051215
Procarbazine, lomustine, vincristine combination may be effective in adult medulloblastoma patients with systemic metastases. Journal of neuro-oncology 20051101
Liposome-mediated transfection of mature taste cells. Journal of neurobiology 20051001
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. Journal of biotechnology 20050929
Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies. British journal of cancer 20050905
Ependymal tumors in childhood. Pediatric blood & cancer 20050901
Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF. Japanese journal of clinical oncology 20050901
Salvage therapy of progressive and recurrent Hodgkin's disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050901
Oral combination chemotherapy in the treatment of AIDS-associated Hodgkin's disease. East African medical journal 20050901
Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma. Melanoma research 20050801
Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20050715
Beneficial effects of spin-labelled nitrosourea on CCNU-induced oxidative stress in rat blood compared with vitamin E. Die Pharmazie 20050701
[Favourable result for temozolomide in recurrent high-grade glioma]. Nederlands tijdschrift voor geneeskunde 20050618
Survival of adults treated for medulloblastoma using paediatric protocols. European journal of cancer (Oxford, England : 1990) 20050601
Role of novel targeted therapies in the clinic. British journal of cancer 20050601
Lomustine (chloroethylnitrosourea [CCNU]), ifosfamide, bleomycin, vincristine, and cisplatin (CIBO-P) is an effective regimen for patients with poor prognostic refractory or multiple disease recurrent aggressive non-Hodgkin lymphoma. Cancer 20050515
P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy. Journal of neuro-oncology 20050501
[Brief review of the neuro oncology for recent three decades in Japan]. Gan to kagaku ryoho. Cancer & chemotherapy 20050401
Re-induction of hormonal sensitivity in hormone-refractory prostate cancer--fact or fiction? Nature clinical practice. Oncology 20050401
Therapeutic effects of Holmium-166 chitosan complex in rat brain tumor model. Yonsei medical journal 20050227
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine. Cancer 20050215
Non-small-cell lung cancer in a French department, (1982-1997): management and outcome. British journal of cancer 20050214
Chlorambucil and lomustine (CL56) in absolute hormone refractory prostate cancer: re-induction of endocrine sensitivity an unexpected finding. British journal of cancer 20050117
Use of lomustine to treat cutaneous nonepitheliotropic lymphoma in a cat. Journal of the American Veterinary Medical Association 20050115
Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma. Journal of neuro-oncology 20050101
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma. Neuro-oncology 20050101
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. Chang Gung medical journal 20050101
Economic evaluation of temozolomide in the treatment of recurrent glioblastoma multiforme. PharmacoEconomics 20050101
Assay of CCNU in tumor by RP-HPLC. Artificial cells, blood substitutes, and immobilization biotechnology 20050101
Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives. BMC cancer 20050101
Treatment of patients of high-risk group of medulloblastoma with the adjuvant lomustine, cisplatin, and vincristine chemotherapy. Medicina (Kaunas, Lithuania) 20050101
Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent. Journal of experimental therapeutics & oncology 20050101
[Results of hyperfractionated radiation therapy used in combination with lomustin in malignant gliomas of the brain]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 20050101
Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy. Pediatric blood & cancer 20041201
Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity. Journal of neurochemistry 20041201
The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma. Melanoma research 20041201
Metastatic glioblastoma in cervical lymph node after repeated craniotomies: report of a case with diagnosis by fine needle aspiration. Journal of Korean medical science 20041201
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. Cancer 20041101
Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study. British journal of cancer 20041101
[Therapeutic efficacy of hematopoietic stem cell transplantation in patients with chronic myelogenous leukemia]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20041101
Diagnosis and management of oligodendroglioma. Seminars in oncology 20041001
Current controversies in the radiotherapeutic management of adult low-grade glioma. Seminars in oncology 20041001
[The molecular genetics of oligodendroglioma]. Zhonghua bing li xue za zhi = Chinese journal of pathology 20041001
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. Neurology 20040914
Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. International journal of cancer 20040910
Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer. British journal of cancer 20040816
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 20040810
Gliomatosis cerebri: better definition, better treatment. Neurology 20040727
Initial chemotherapy in gliomatosis cerebri. Neurology 20040727
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. International journal of radiation oncology, biology, physics 20040601
Intrinsic brainstem choroid plexus papilloma. Case report. Journal of neurosurgery 20040601
Long-term outcome of oligodendrogliomas. Neurology 20040525
[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults]. Revue neurologique 20040501
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. British journal of cancer 20040419
Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404. International journal of radiation oncology, biology, physics 20040315
Concurrent chemotherapy and reduced-dose cranial spinal irradiation followed by conformal posterior fossa tumor bed boost for average-risk medulloblastoma: efficacy and patterns of failure. International journal of radiation oncology, biology, physics 20040315
Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme. Cancer 20040315
Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1. British journal of pharmacology 20040301
Second-line treatment with carboplatin for recurrent or progressive oligodendroglial tumors after PCV (procarbazine, lomustine, and vincristine) chemotherapy: a phase II study. Cancer 20040215
Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy. Neuroradiology 20040201
Second malignancies after chemotherapy and radiotherapy for Hodgkin disease. American journal of clinical oncology 20040201
Chemotherapy of anaplastic oligodendroglial tumours. Expert opinion on pharmacotherapy 20040201
Molecular genetic study of a metastatic oligodendroglioma. Journal of neuro-oncology 20040201
Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. Journal of veterinary internal medicine 20040101
Metastatic lung disease to the central nervous system: in vitro response to chemotherapeutic agents. Journal of neuro-oncology 20040101
Human osteosarcoma xenografts and their sensitivity to chemotherapy. Pathology oncology research : POR 20040101
Preradiation chemotherapy with VM-26 and CCNU in patients with glioblastoma multiforme. Tumori 20040101
Overdose of lomustine: report of two cases. Tumori 20040101
The toxicological study of CCNU controlled release film in vivo. Artificial cells, blood substitutes, and immobilization biotechnology 20040101
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea. Report on carcinogens : carcinogen profiles 20040101
Oligodendroglioma. Current treatment options in oncology 20031201
Medulloblastomas and central nervous system primitive neuroectodermal tumors. Current treatment options in oncology 20031201
Systemic chemotherapy in the treatment of malignant melanoma. Expert opinion on pharmacotherapy 20031201
The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature. Surgical neurology 20031201
[Suppression of nitric oxide on cytotoxicity of Lomustine in glioma cell line BT- 325]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031201
The treatment of elderly patients with high-grade gliomas. Seminars in oncology 20031201
Promising survival for patients with glioblastoma multiforme treated with individualised chemotherapy based on in vitro drug sensitivity testing. British journal of cancer 20031117
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis. Surgical neurology 20031101
High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma. Journal of neuro-oncology 20031101
Spin labeled antioxidants protect bacteria against the toxicity of alkylating antitumor drug CCNU. Toxicology letters 20031015
Adult height and adult sitting height in childhood medulloblastoma survivors. The Journal of clinical endocrinology and metabolism 20031001
Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945. Cancer 20030915
Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents. Cancer chemotherapy and pharmacology 20030901
First European case of serotype A MATa Cryptococcus neoformans infection. Emerging infectious diseases 20030901
Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri. Neurology 20030812
Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin. British journal of cancer 20030804
Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. Annals of diagnostic pathology 20030801
Summary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002). British journal of cancer 20030801
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas. British journal of cancer 20030721
Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030715
Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030701
Tolerance of nitrosurea-based multiagent chemotherapy regime for low-grade pediatric gliomas. Journal of neuro-oncology 20030701
Primary leptomeningeal primitive neuroectodermal tumor. Journal of neuro-oncology 20030701
[Acute myeloblastic leukemia in adults: evaluation of the AML 06/96 protocol]. La Tunisie medicale 20030701
Survival improvement in patients with glioblastoma multiforme during the last 20 years in a single tertiary-care center. Wiener klinische Wochenschrift 20030624
High-dose therapy and autologous stem-cell transplantation versus conventional therapy for patients with advanced Hodgkin's lymphoma responding to front-line therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030615
Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents. Toxicology in vitro : an international journal published in association with BIBRA 20030601
Conformal irradiation for pure and mixed oligodendroglioma: the experience of Centre Leon Berard Lyon. International journal of radiation oncology, biology, physics 20030501
Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group. Cancer 20030501
Bleomycin, vincristine, lomustine and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma. European journal of cancer (Oxford, England : 1990) 20030501
Combined modality therapy for poorly differentiated gliomas of the posterior fossa in children: a Children's Cancer Group report. Journal of neuro-oncology 20030501
New chemotherapy agents in veterinary medicine. The Veterinary clinics of North America. Small animal practice 20030501
Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972. Annals of oncology : official journal of the European Society for Medical Oncology 20030401
Partially successful treatment of a patient with chronic lymphocytic leukemia and Hodgkin's disease: case report and literature review. American journal of hematology 20030401
Recent developments in the molecular characterization and treatment of oligodendroglial tumors. Neuro-oncology 20030401
Survival and prognostic factors of patients with unresectable glioblastoma multiforme. Anti-cancer drugs 20030401
Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial. Melanoma research 20030401
Interobserver variability in the radiological assessment of response to chemotherapy in glioma. Neurology 20030311
Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. Pediatric hematology and oncology 20030301
Glioma treatment, radionecrosis, and growth factors. In regard to Levin et al., IJROBP 2002;53:58-66. International journal of radiation oncology, biology, physics 20030301
Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. Cancer 20030301
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20030301
Genetic alterations of human brain tumors as molecular prognostic factors. Neuropathology : official journal of the Japanese Society of Neuropathology 20030301
Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme. British journal of cancer 20030224
A prospective study on glioblastoma in the elderly. Cancer 20030201
Feasibility and toxicity of CCNU therapy in elderly patients with glioblastoma multiforme. Anti-cancer drugs 20030201
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030115
Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri. Neurology 20030114
Primary intraspinal primitive neuroectodermal tumor: report of two cases and review of the literature. Journal of neuro-oncology 20030101
Current chemotherapy for glioblastoma. Cancer journal (Sudbury, Mass.) 20030101
Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience. Pediatric hematology and oncology 20030101
Chemotherapy versus best supportive care for extensive small cell lung cancer. The Cochrane database of systematic reviews 20030101
[Use of modern technologies in the diagnosis and combined treatment of brain stem tumors]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101
Medication sheets for patients. Oral chemotherapy. Clinical journal of oncology nursing 20030101
Guidelines for the treatment of adult intra-cranial grade II-III ependymal tumours. Forum (Genoa, Italy) 20030101
An elevated serum beta-2-microglobulin level is an adverse prognostic factor for overall survival in patients with early-stage Hodgkin disease. Cancer 20021215
Recurrent malignant glioma in adults. Current treatment options in oncology 20021201
Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD), and human leukocyte interferon for metastatic uveal melanoma. Cancer 20021201
Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer 20021201
Coeliac disease following high-dose chemotherapy. Clinical oncology (Royal College of Radiologists (Great Britain)) 20021201
Acute diarrhea during adjuvant therapy for rectal cancer: a detailed analysis from a randomized intergroup trial. International journal of radiation oncology, biology, physics 20021001
Phase I study of fotemustine in pediatric patients with refractory brain tumors. Cancer 20020915
Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis. Cancer 20020901
Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate. Journal of neuro-oncology 20020901
Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801
Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil. Clinical endocrinology 20020801
Intensified PCV-chemotherapy with optional stem cell support in recurrent malignant oligodendroglioma. Journal of neurology 20020801
Treatment of intracranial metastatic esthesioneuroblastoma. Cancer 20020715
Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial. American journal of clinical oncology 20020601
Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer research 20020501
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. International journal of radiation oncology, biology, physics 20020501
[Chemo-radiotherapy for malignant brain tumors]. Gan to kagaku ryoho. Cancer & chemotherapy 20020501
NO-mediated chemoresistance in C6 glioma cells. Annals of the New York Academy of Sciences 20020501
Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma. Journal of neuro-oncology 20020501
11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes, chromosomes & cancer 20020401
Structure-based design of nitrosoureas containing tyrosine derivatives as potential antimelanoma agents. European journal of medicinal chemistry 20020401
Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase. Cancer research 20020315
Evaluation of naphthal-NU, a 2-chloroethylnitrosourea derivative of naphthalimide, as a mixed-function anticancer agent. Journal of experimental & clinical cancer research : CR 20020301
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma. International journal of cancer 20020201
Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020201
Treatment of intracranial metastatic esthesioneuroblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020101
Preradiation chemotherapy for pediatric patients with high-grade glioma. Cancer 20020101
Study of three hepatobiliary agents in experimental animals. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20020101
Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen. Journal of the American Animal Hospital Association 20020101
Radiotherapy alone for lymphocyte-predominant Hodgkin's disease. Cancer journal (Sudbury, Mass.) 20020101
[Role of adjuvant chemotherapy in the treatment of medulloblastoma in children]. Voprosy onkologii 20020101
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea. Report on carcinogens : carcinogen profiles 20020101
Adults with newly diagnosed high-grade gliomas. Current treatment options in oncology 20011201
Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results. International journal of radiation oncology, biology, physics 20011115
The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity. Mutation research 20011018
Medical Research Council adjuvant trial in high-grade gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011001
Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group. American journal of clinical oncology 20011001
PCV chemotherapy for oligodendroglioma: response analyzed on T2 weighted-MRI. Journal of neuro-oncology 20011001
Nitric oxide and free stable nitroxyl radicals in the mechanism of biological action of the spin-labeled compounds. Medical hypotheses 20010901
Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. International journal of radiation oncology, biology, physics 20010801
PCV for oligodendroglial tumors: in search of prognostic factors for response and survival. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20010801
Melanoma-associated retinopathy: does autoimmunity prolong survival? Clinical & experimental ophthalmology 20010801
Chemotherapy for the treatment of oligodendroglial tumors. Seminars in oncology 20010801
Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU. Cancer gene therapy 20010801
Two glycine containing 2-chloroethylnitrosoureas--a comparative study on some physicochemical properties, in vivo antimelanomic effects and immunomodulatory properties. International journal of pharmaceutics 20010717
CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release. Oncogene 20010712
Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones. European journal of haematology 20010701
Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myeloma. Cancer chemotherapy and pharmacology 20010701
PCV chemotherapy for recurrent glioblastoma multiforme. Neurology 20010626
Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group Study. European Organization for Research and Treatment of Cancer. Gynecologic oncology 20010601
Lipid association improves the therapeutic index of lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] to suppress 36B-10 tumor growth in rats. Cancer research 20010501
Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010501
Inducible nitric oxide synthase neutralizes carbamoylating potential of 1,3-bis(2-chloroethyl)-1-nitrosourea in c6 glioma cells. The Journal of pharmacology and experimental therapeutics 20010401
Chemotherapy of low-grade gliomas. Seminars in radiation oncology 20010401
Multidisciplinary management of adult anaplastic oligodendrogliomas and anaplastic mixed oligo-astrocytomas. Seminars in radiation oncology 20010401
[Post-operative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of German prospective randomised trial HIT'91]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20010401
APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis. Cell death and differentiation 20010401
Oral combination chemotherapy in conjunction with filgrastim (G-CSF) in the treatment of AIDS-related non-Hodgkin's lymphoma: evaluation of the role of G-CSF; quality-of-life analysis and long-term follow-up. American journal of hematology 20010301
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells. Gene therapy 20010301
[Therapeutic effect on glioblastoma of chemotherapy on the basis of brain irradiation]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20010301
Incidence, cost, and outcomes of bleeding and chemotherapy dose modification among solid tumor patients with chemotherapy-induced thrombocytopenia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215
Recurrent intracranial ependymoma in children: salvage therapy with oral etoposide. Pediatric neurology 20010201
Spin labelled nitrosoureas and triazenes and their non-labelled clinically used analogues--a comparative study on their physicochemical properties and antimelanomic effects. International journal of pharmaceutics 20010116
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010115
PCV chemotherapy for recurrent glioblastoma multiforme. Neurology 20010109
Radiotherapy of esthesioneuroblastoma. International journal of radiation oncology, biology, physics 20010101
Multiple myeloma in elderly patients: presenting features and outcome. European journal of haematology 20010101
Adult medulloblastoma: multiagent chemotherapy. Neuro-oncology 20010101
Phase I evaluation of CCNU (lomustine) in tumor-bearing cats. Journal of veterinary internal medicine 20010101
Bleomycin, lomustine, cyclophosphamide, vincristine, procarbazine and prednisone (BLEO-CCVPP) in patients with Hodgkin's disease who relapsed after radiotherapy alone: a long-term follow-up study of the Eastern Cooperative Oncology Group (E3481). Leukemia & lymphoma 20010101
Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101
Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics. Anti-cancer drug design 20010101
A possible correlation between unscheduled DNA repair and cholesterolemia in Wistar rat, modulated by vitamin E. Roumanian archives of microbiology and immunology 20010101
Venoocclusive liver disease (VOD) as a complication of Wilms' tumour management in the series of consecutive 206 patients. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie 20001001
Myeloablative chemotherapy for recurrent aggressive oligodendroglioma. Neuro-oncology 20000401
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults. Journal of neuro-oncology 19980801
Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19941001
Aplastic anemia induced by cyclohexylchloroethylnitrousurea. Anti-cancer drugs 19940201
Cardiorespiratory decompensation following methylprednisolone administration. Pediatric hematology and oncology 19930101
Acute cerebral oedema induced by methotrexate. BMJ (Clinical research ed.) 19890513
CCNU-adriamycin association induces earlier and more severe nephropathy in rats. Archives of toxicology 19880101
Chemotherapy for adenocarcinoma of the lung (WHO III): A randomized study of vindesine versus lomustine, cyclophosphamide, and methotrexate versus all four drugs. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19870801
Sudden onset of blindness in patients treated with oral CCNU and low-dose cranial irradiation. Cancer 19870301
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital. Cancer chemotherapy and pharmacology 19870101
Misonidazole-induced chemopotentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea toxicity in O6-methylguanine-DNA methyltransferase proficient (Mer+) and deficient (Mer-) cell lines. Cancer research 19860601
[Vipoma. 9-year observations using currently available therapy methods]. Deutsche medizinische Wochenschrift (1946) 19860221
Cardiotoxicity as a result of 5-fluorouracil therapy. Tumori 19850227
Nephrotoxicity of lomustine. A case report and literature review. Cancer chemotherapy and pharmacology 19850101
Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe. Annals of internal medicine 19841001
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice. British journal of cancer 19830501
Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine. Cancer treatment reports 19830301
Psychological response of patients receiving two drug regimens for lung carcinoma. The American journal of psychiatry 19830101
Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU. British journal of cancer 19820801
Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships. International journal of radiation oncology, biology, physics 19820101
Nephrotoxicity of nitrosoureas. Cancer 19810915
[Chronic renal failure after CCNU treatment (author's transl)]. La Nouvelle presse medicale 19801101
Cardiotoxicity of 5-fluorouracil. Tumori 19801031
CCNU nephrotoxicity following sustained remission in oat cell carcinoma. Cancer treatment reports 19790201
Single-agent chemotherapy of brain tumors. A five-year review. Archives of neurology 19761101
Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU. Acta neuropathologica 19760131
Graft versus leukemia. VI. Adoptive immunotherapy in combination with chemoradiotherapy for spontaneous leukemia-lymphoma in AKR mice. Journal of the National Cancer Institute 19751101
Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma. Cancer 19720801
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