9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells. | Chemico-biological interactions 20180325 |
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Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance. | Cancer letters 20140901 |
Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). | Bioorganic & medicinal chemistry 20120201 |
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. | Cancer cell 20110517 |
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