Home Other Building Blocks 4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

CAS No.:
1255580-76-7
Catalog Number:
AG000NUW
Molecular Formula:
C30H47N5O2
Molecular Weight:
509.7265
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$110
- +
5mg
99%
1 week
United States
$157
- +
10mg
99%
1 week
United States
$207
- +
50mg
99%
1 week
United States
$473
- +
100mg
99%
1 week
United States
$790
- +
Product Description
Catalog Number:
AG000NUW
Chemical Name:
4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CAS Number:
1255580-76-7
Molecular Formula:
C30H47N5O2
Molecular Weight:
509.7265
MDL Number:
MFCD17215972
IUPAC Name:
2-cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
InChI:
InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
InChI Key:
QOECJCJVIMVJGX-UHFFFAOYSA-N
SMILES:
COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)C1CCCCC1
UNII:
26A103L2FO
Properties
Complexity:
660  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
509.373g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
509.739g/mol
Monoisotopic Mass:
509.373g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
62.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.3  
Literature
Title Journal
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20160101
Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos. Reproduction in domestic animals = Zuchthygiene 20140401
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS medicinal chemistry letters 20140213
Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment. PloS one 20140101
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of medicinal chemistry 20131114
Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death. Cell death & disease 20130201
Oncoepigenomics: making histone lysine methylation count. European journal of medicinal chemistry 20121001
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of medicinal chemistry 20110908
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology 20110710
Properties