Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
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MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor. | Toxicology and applied pharmacology 20171101 |
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine. | Chemico-biological interactions 20170601 |
In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. | Toxicology in vitro : an international journal published in association with BIBRA 20170401 |
Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. | Toxicology letters 20160122 |
Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20140101 |
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. | Toxicology in vitro : an international journal published in association with BIBRA 20130901 |
The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. | Toxicology in vitro : an international journal published in association with BIBRA 20130801 |
Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. | Journal of applied toxicology : JAT 20130201 |
Dextromethorphan-induced psychotoxic behaviors cause sexual dysfunction in male mice via stimulation of σ-1 receptors. | Neurochemistry international 20121101 |
Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson's disease: role of NMDA vs. 5-HT1A receptors. | The European journal of neuroscience 20121101 |
Liquid chromatography/quadrupole-time-of-flight mass spectrometry with metabolic profiling of human urine as a tool for environmental analysis of dextromethorphan. | Journal of chromatography. A 20121012 |
Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization in rats. | Synapse (New York, N.Y.) 20121001 |
Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing. | International journal of clinical pharmacology and therapeutics 20121001 |
High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. | Psychopharmacology 20120901 |
Dextromethorphan abuse leading to assault, suicide, or homicide. | Journal of forensic sciences 20120901 |
Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901 |
Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan. | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120901 |
Viscerosomatic facilitation in a subset of IBS patients, an effect mediated by N-methyl-D-aspartate receptors. | The journal of pain : official journal of the American Pain Society 20120901 |
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. | Journal of clinical pharmacology 20120801 |
Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan. | Drug development and industrial pharmacy 20120801 |
Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice. | Journal of clinical pharmacy and therapeutics 20120801 |
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection. | Journal of viral hepatitis 20120801 |
Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. | Therapeutic drug monitoring 20120801 |
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance. | Drug metabolism and disposition: the biological fate of chemicals 20120701 |
Introduction to the special issue on 'Advances in Biomedical Engineering and Computing: the MEDICON Conference Case' selected papers from MEDICON 2010. | Computer methods and programs in biomedicine 20120701 |
Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615 |
Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers. | Xenobiotica; the fate of foreign compounds in biological systems 20120601 |
An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan. | Medical hypotheses 20120601 |
Mechanism-based CYP2D6 inactivation by acridone alkaloids of Indonesian medicinal plant Lunasia amara. | Fitoterapia 20120601 |
Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. | Die Pharmazie 20120601 |
Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics. | Talanta 20120530 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120515 |
Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells. | Neuroscience letters 20120510 |
CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population. | European journal of clinical pharmacology 20120501 |
The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder. | Journal of affective disorders 20120501 |
Factors that affect the diagnostic yield of endobronchial ultrasonography-assisted transbronchial lung biopsy. | Journal of laparoendoscopic & advanced surgical techniques. Part A 20120501 |
A herbal-drug interaction study of keishi-bukuryo-gan, a traditional herbal preparation used for menopausal symptoms, in healthy female volunteers. | The Journal of pharmacy and pharmacology 20120501 |
Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy. | Journal of the Formosan Medical Association = Taiwan yi zhi 20120501 |
Antitussive effects of memantine in guinea pigs. | Chest 20120401 |
The effect of dacomitinib (PF-00299804) on CYP2D6 activity in healthy volunteers who are extensive or intermediate metabolizers. | Cancer chemotherapy and pharmacology 20120401 |
GABAA agonist reduces visual awareness: a masking-EEG experiment. | Journal of cognitive neuroscience 20120401 |
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. | Pharmacotherapy 20120401 |
Honey for acute cough in children. | The Cochrane database of systematic reviews 20120314 |
Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. | Phytotherapy research : PTR 20120301 |
Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats. | American journal of respiratory cell and molecular biology 20120301 |
Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. | Clinical drug investigation 20120301 |
Gas chromatographic method validation for the analysis of major components in illicit heroin seized in Malaysia. | Science & justice : journal of the Forensic Science Society 20120301 |
Repeated administration of berberine inhibits cytochromes P450 in humans. | European journal of clinical pharmacology 20120201 |
Emphasizing the value of phenotyping in patients receiving tamoxifen. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120201 |
Efficacy and safety of dextromethorphan/quinidine at two dosage levels for diabetic neuropathic pain: a double-blind, placebo-controlled, multicenter study. | Pain medicine (Malden, Mass.) 20120201 |
Preparation and evaluation of taste-masked dextromethorphan oral disintegrating tablet. | Pharmaceutical development and technology 20120101 |
Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia. | Brain & development 20120101 |
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole. | Drug metabolism and disposition: the biological fate of chemicals 20120101 |
Dextromethorphan/quinidine for chorea: an open-label assessment. | Clinical neuropharmacology 20120101 |
A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers. | Clinical drug investigation 20120101 |
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. | Biomedical research (Tokyo, Japan) 20120101 |
Low-dose dextromethorphan, a NADPH oxidase inhibitor, reduces blood pressure and enhances vascular protection in experimental hypertension. | PloS one 20120101 |
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. | Behavioural brain research 20111201 |
Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer. | The FEBS journal 20111201 |
CYP2D6 and tamoxifen: awaiting the denouement. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111201 |
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. | Cancer chemotherapy and pharmacology 20111101 |
Intentional Coricidin product exposures among Illinois adolescents. | The American journal of drug and alcohol abuse 20111101 |
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity. | Synapse (New York, N.Y.) 20111001 |
Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. | Neurobiology of disease 20111001 |
Determination of dextromethorphan in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry. | Analytical and bioanalytical chemistry 20111001 |
Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. | Drug and alcohol dependence 20110901 |
N-Methyl-D-aspartate receptor modulators block hyperalgesia induced by acute low-dose morphine. | Clinical and experimental pharmacology & physiology 20110901 |
Dextromethorphan abuse in teens: beware acetaminophen poisoning! | CJEM 20110901 |
Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820 |
Personalized tamoxifen: what is the best way forward? | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820 |
Concerns about dextromethorphan as a potential rapid-acting antidepressant. | Medical hypotheses 20110801 |
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | Journal of medicinal chemistry 20110714 |
Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments. | Expert review of neurotherapeutics 20110701 |
Current concepts in the pharmacotherapy of pseudobulbar affect. | Drugs 20110618 |
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110614 |
Dextromethorphan/quinidine (Nuedexta) for pseudobulbar affect. | The Medical letter on drugs and therapeutics 20110613 |
Late-onset nonketotic hyperglycinemia caused by a novel homozygous missense mutation in the GLDC gene. | Molecular genetics and metabolism 20110601 |
Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adduction. | Drug metabolism and disposition: the biological fate of chemicals 20110601 |
Investigation of antitussive and toxicological activity of Ballota limbata in mice. | Pharmaceutical biology 20110601 |
Monitoring trends in dextromethorphan abuse using the National Poison Data System: 2000-2010. | Clinical toxicology (Philadelphia, Pa.) 20110601 |
Drug metabolism in hemorrhagic shock: pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model. | The Journal of surgical research 20110515 |
QTc prolongation due to dextromethorphan. | International journal of cardiology 20110505 |
Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype. | Psychopharmacology 20110501 |
Dextromethorphan as a potential rapid-acting antidepressant. | Medical hypotheses 20110501 |
Optimum design of experiments for enzyme inhibition kinetic models. | Journal of biopharmaceutical statistics 20110501 |
Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. | Clinical pharmacokinetics 20110501 |
Dextromethorphan/quinidine: in pseudobulbar affect. | CNS drugs 20110501 |
Experience and analysis of level VII cervical lymph node metastases in patients with papillary thyroid carcinoma. | Journal of the Korean Surgical Society 20110501 |
Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS. | Analytical and bioanalytical chemistry 20110401 |
Molecularly imprinted polymer cartridges coupled on-line with high performance liquid chromatography for simple and rapid analysis of dextromethorphan in human plasma samples. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110401 |
[Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401 |
Do cough suppressants or honey help pediatric cough? | Canadian family physician Medecin de famille canadien 20110401 |
Developmental toxicity of dextromethorphan in zebrafish embryos/larvae. | Journal of applied toxicology : JAT 20110301 |
Dextromethorphan abuse masquerading as a recurrent seizure disorder. | Pediatric emergency care 20110301 |
Gene copy number variations: it is important to determine which allele is affected. | Pharmacogenomics 20110301 |
Recommendations for the proper use of nonprescription cough suppressants and expectorants in solid-organ transplant recipients. | Progress in transplantation (Aliso Viejo, Calif.) 20110301 |
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine. | Fundamental & clinical pharmacology 20110201 |
Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome. | The journal of pain : official journal of the American Pain Society 20110201 |
Differential alterations of GABA(A) receptor (α1, β2, γ2 subunit) expression and increased seizure susceptibility in rat offspring from morphine-addicted mothers: beneficial effect of dextromethorphan. | Neuroscience letters 20110201 |
Application of experimental design in optimization of the separation condition for determination of four active components in cold medicines by flow injection-capillary electrophoresis. | Journal of chromatographic science 20110201 |
Dextromethorphan: abusing the overused. | Singapore medical journal 20110201 |
[CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110201 |
[CYP2D6 genotypes and phenotypes in Chinese Han, Uygur and Kazakh populations]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110201 |
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20110125 |
Effect of dextromethorphan on human K(v)1.3 channel activity: involvement of C-type inactivation. | European journal of pharmacology 20110125 |
Floating matrix dosage form for dextromethorphan hydrobromide based on gas forming technique: in vitro and in vivo evaluation in healthy volunteers. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110118 |
Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110101 |
Nociceptive behavior following hindpaw burn injury in young rats: response to systemic morphine. | Pain medicine (Malden, Mass.) 20110101 |
Serotonin syndrome induced by dextromethorphan (Medicon) administrated at the conventional dose. | Geriatrics & gerontology international 20110101 |
Myoclonus after dextromethorphan administration in peritoneal dialysis. | The Annals of pharmacotherapy 20110101 |
Antepartum fetal heart rate feature extraction and classification using empirical mode decomposition and support vector machine. | Biomedical engineering online 20110101 |
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. | Molecular neurodegeneration 20110101 |
[Pharmacokinetic study of a new chewing gum dextromethorphan delivery system]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110101 |
Cough syrup psychosis. | CJEM 20110101 |
The Ti-Epiplating system as an alternative for ear prostheses in burned patients. | Journal of burn care & research : official publication of the American Burn Association 20110101 |
Pharmacological and clinical overview of cloperastine in treatment of cough. | Therapeutics and clinical risk management 20110101 |
Dextromethorphan inhibits the glutamatergic synaptic transmission in the nucleus tractus solitarius of guinea pigs. | Journal of pharmacological sciences 20110101 |
Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. | Journal of pharmacological sciences 20110101 |
Simultaneous determination of dextromethorphan and its metabolite dextrorphan in plasma samples using second-order calibration coupled with excitation-emission matrix fluorescence. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101 |
Dextromethorphan abuse in Texas, 2000-2009. | Journal of addictive diseases 20110101 |
Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757. | Pharmacology 20110101 |
Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. | Journal of biomedical science 20110101 |
Knowledge, attitudes and practices of health professionals and women towards medication use in breastfeeding: A review. | International breastfeeding journal 20110101 |
[Clinical practice guidelines in dextromethorphan poisoning pre-hospital management]. | Przeglad lekarski 20110101 |
Use of CNS medications and cognitive decline in the aged: a longitudinal population-based study. | BMC geriatrics 20110101 |
Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury. | TheScientificWorldJournal 20110101 |
Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats. | Neuro endocrinology letters 20110101 |
Evaluation of the reinforcing and subjective effects of heroin in combination with dextromethorphan and quinidine. | Journal of opioid management 20110101 |
Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review. | British journal of clinical pharmacology 20101201 |
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases. | Journal of medicinal chemistry 20101125 |
Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. | Annals of neurology 20101101 |
Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. | Clinical pharmacology and therapeutics 20101101 |
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. | Pharmacogenetics and genomics 20101101 |
Advisers vote against declaring dextromethorphan a controlled substance. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101101 |
Comparative evaluation of ten different condylar base fracture osteosynthesis techniques. | The British journal of oral & maxillofacial surgery 20101001 |
Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population. | European journal of clinical pharmacology 20101001 |
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. | Minerva anestesiologica 20101001 |
Neuropsychopharmacological understanding for therapeutic application of morphinans. | Archives of pharmacal research 20101001 |
On-line drug metabolites generation and their subsequent target analysis by capillary zone electrophoresis with UV-absorption detection. | Electrophoresis 20101001 |
Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. | European journal of clinical pharmacology 20100901 |
Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan. | Drug metabolism and disposition: the biological fate of chemicals 20100901 |
Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20100901 |
Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. | Cancer prevention research (Philadelphia, Pa.) 20100901 |
Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes. | Drug testing and analysis 20100901 |
Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets. | Acta pharmaceutica (Zagreb, Croatia) 20100901 |
Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. | Biomedical chromatography : BMC 20100801 |
Co-administration of dextromethorphan and morphine: reduction of post-operative pain and lack of influence on morphine metabolism. | Basic & clinical pharmacology & toxicology 20100801 |
Impact of the voluntary withdrawal of over-the-counter cough and cold medications on pediatric ingestions reported to poison centers. | Pharmacoepidemiology and drug safety 20100801 |
In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. | Journal of ethnopharmacology 20100720 |
A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. | Journal of alternative and complementary medicine (New York, N.Y.) 20100701 |
Dextromethorphan withdrawal and dependence syndrome. | Deutsches Arzteblatt international 20100701 |
LC for analysis of two sustained-release mixtures containing cough cold suppressant drugs. | Journal of chromatographic science 20100701 |
L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100505 |
Variability in drug metabolizing enzyme activity in HIV-infected patients. | European journal of clinical pharmacology 20100501 |
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501 |
[Comparison of port needle with safety device between Huber Plus (HP) and Poly PERF Safe (PPS)]. | Gan to kagaku ryoho. Cancer & chemotherapy 20100501 |
Carbon paste and PVC electrodes for the flow injection potentiometric determination of dextromethorphan. | Talanta 20100415 |
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain. | IDrugs : the investigational drugs journal 20100401 |
Coadministration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. | Fertility and sterility 20100315 |
Evaluation of the analgesic effect of dextromethorphan and its interaction with nitric oxide on sciatic nerve ligated rats. | Journal of acupuncture and meridian studies 20100301 |
Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats. | Toxicology and industrial health 20100201 |
Test compounds for detecting the silanol effect on the elution of ionized amines in reversed-phase LC. | Journal of separation science 20100201 |
Preoperative oral dextromethorphan does not reduce pain or morphine consumption after open cholecystectomy. | Middle East journal of anaesthesiology 20100201 |
Honey for acute cough in children. | The Cochrane database of systematic reviews 20100120 |
Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4. | Chemico-biological interactions 20100105 |
NMR studies of dextromethorphan in both isotropic and anisotropic states. | Chirality 20100101 |
Urinary incontinence in spinal cord injured individuals 10-45 years after injury. | Spinal cord 20100101 |
Effect of metabolic blockade on the psychoactive effects of dextromethorphan. | Human psychopharmacology 20100101 |
Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. | PloS one 20100101 |
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. | Drug metabolism letters 20100101 |
Association of circulating angiotensin converting enzyme activity with respiratory muscle function in infants. | Respiratory research 20100101 |
Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos. | Pharmacology 20100101 |
Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature. | Drug metabolism and pharmacokinetics 20100101 |
Multivariate optimization and validation of a capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromur, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate in a pharmaceutical preparation using response surface methodology. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101 |
Flexible Macroblock Ordering for Context-Aware Ultrasound Video Transmission over Mobile WiMAX. | International journal of telemedicine and applications 20100101 |
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? | Antiviral therapy 20100101 |
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. | Pharmacology, biochemistry, and behavior 20091201 |
[Removal of metallic foreign body in the soft tissue under fluoroscopy: 10 years of experiences]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091201 |
[Serotonin syndrome caused by an overdose of dextromethorphan, Medicon]. | Masui. The Japanese journal of anesthesiology 20091201 |
A 60-year-old woman with agitation and psychosis following ingestion of dextromethorphan and opioid analgesics. | Journal of psychopharmacology (Oxford, England) 20091101 |
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. | Biomedical chromatography : BMC 20091101 |
Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury. | Pharmacology, biochemistry, and behavior 20091101 |
(13)C breath tests in personalized medicine: fiction or reality? | Expert review of molecular diagnostics 20091101 |
Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats. | Canadian journal of physiology and pharmacology 20091101 |
Effects of drugs and drug combinations in pigeons trained to discriminate among pentobarbital, dizocilpine, a combination of these drugs, and saline. | Journal of the experimental analysis of behavior 20091101 |
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers. | Basic & clinical pharmacology & toxicology 20091001 |
Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management. | Current opinion in anaesthesiology 20091001 |
Effects of dextromethorphan/quinidine on auditory event-related potentials in multiple sclerosis patients with pseudobulbar affect. | Journal of clinical psychopharmacology 20091001 |
Do OTC remedies relieve cough in acute URIs? | The Journal of family practice 20091001 |
A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. | Brain research 20090908 |
Combined dextromethorphan and chlorpheniramine intoxication in impaired drivers. | Journal of forensic sciences 20090901 |
Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects. | Psychiatria Danubina 20090901 |
Best drugs for what ails you: the brands to buy--and those to skip. | Consumer reports 20090901 |
Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801 |
CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis. | Drug metabolism and disposition: the biological fate of chemicals 20090801 |
Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans. | Drug metabolism and disposition: the biological fate of chemicals 20090701 |
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? | Pain 20090701 |
Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. | Neurochemistry international 20090701 |
A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090601 |
Cough in the palliative care setting. | Canadian family physician Medecin de famille canadien 20090601 |
Screening of codeine, dextromethorphan & dextropropoxyphene for their genotoxicity in Swiss albino mice. | The Indian journal of medical research 20090601 |
Simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography. | Talanta 20090515 |
Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501 |
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds. | Bioorganic & medicinal chemistry 20090501 |
[Fever induced by various drugs]. | Rinsho byori. The Japanese journal of clinical pathology 20090501 |
Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays. | Journal of medicinal chemistry 20090423 |
Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese. | Drug metabolism and disposition: the biological fate of chemicals 20090401 |
Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice. | Cardiovascular research 20090401 |
Overdose in infant caused by over-the-counter cough medicine. | Southern medical journal 20090401 |
A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. | Therapeutic drug monitoring 20090401 |
Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315 |
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol. | Biochemical pharmacology 20090301 |
Five deaths resulting from abuse of dextromethorphan sold over the internet. | Journal of analytical toxicology 20090301 |
[Bone anchored hearing aids (BAHA)]. | HNO 20090301 |
Dextromethorphan hydrobromide preparations on the Belgian market--a comparative study. | Journal de pharmacie de Belgique 20090301 |
Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. | Journal of pharmaceutical sciences 20090201 |
The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction. | The pharmacogenomics journal 20090201 |
Effects of dextromethorphan on electroconvulsive therapy. | Psychiatry and clinical neurosciences 20090201 |
Pre-emptive oral dextromethorphan reduces both postoperative and packing removal pain in patients undergoing nasal surgery. | Saudi medical journal 20090201 |
Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. | European journal of clinical pharmacology 20090101 |
Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. | Brain : a journal of neurology 20090101 |
Characterization of retrieved orthodontic miniscrew implants. | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20090101 |
Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment. | British journal of clinical pharmacology 20090101 |
Amyotrophic lateral sclerosis. | Orphanet journal of rare diseases 20090101 |
The diagnostic role of glycosaminoglycans in pleural effusions: a pilot study. | BMC pulmonary medicine 20090101 |
Effect of fenofibrate on microcirculation and wound healing in healthy and diabetic mice. | European journal of medical research 20090101 |
Dextromethorphan abuse: clinical effects and management. | Journal of the American Pharmacists Association : JAPhA 20090101 |
Retrospective analysis of titanium plate-retained prostheses placed after total rhinectomy. | The International journal of oral & maxillofacial implants 20090101 |
O-demethylation of dextromethorphan using microbial cultures. | Drug metabolism letters 20090101 |
Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. | PloS one 20090101 |
Ultra-fast and optimized method for the preparation of rodent testicular cells for flow cytometric analysis. | Biological procedures online 20090101 |
Re: Myocardial infarction associated with Adderall XR and alcohol use in a young man. | Journal of the American Board of Family Medicine : JABFM 20090101 |
Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. | Journal of biomedical science 20090101 |
Intersexual differences in inhibitory influence of trans-resveratrol on activity of cytochrome P450 2D2 in rats. | Neuro endocrinology letters 20090101 |
[Acute dextromethorphan poisoning based on the records of the Department of Toxicology and Internal Diseases in Poznan]. | Przeglad lekarski 20090101 |
Implant-retained craniofacial prostheses for facial defects. | GMS current topics in otorhinolaryngology, head and neck surgery 20090101 |
Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201 |
Comment on 'Dextromethorphan-induced serotonin syndrome'. | Clinical toxicology (Philadelphia, Pa.) 20081201 |
Accidental dextromethorphan ingestions in children less than 5 years old. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201 |
'DXemon juice:' analytical evaluation of an extraction process for the purification and freebasing of dextromethorphan from cold preparations. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201 |
Effects of common antitussive drugs on the hERG potassium channel current. | Journal of cardiovascular pharmacology 20081201 |
A teenager with focal weakness. | Pediatric emergency care 20081201 |
In vitro metabolism studies of new adenosine A 2A receptor antagonists. | Drug metabolism letters 20081201 |
sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons. | The Journal of pharmacology and experimental therapeutics 20081101 |
The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats. | The Chinese journal of physiology 20081031 |
Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers. | Journal of thrombosis and haemostasis : JTH 20081001 |
Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. | Biochemical pharmacology 20081001 |
The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans. | Journal of clinical psychopharmacology 20081001 |
N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. | Journal of neurosurgical anesthesiology 20081001 |
Dextromethorphan. | Annals of the New York Academy of Sciences 20081001 |
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. | Journal of pharmaceutical and biomedical analysis 20080910 |
Effects of repeated cycles of sterilisation on the mechanical characteristics of titanium miniplates for osteosynthesis. | The British journal of oral & maxillofacial surgery 20080901 |
Tramadol for pain relief in children undergoing adenotonsillectomy: a comparison with dextromethorphan. | The Laryngoscope 20080901 |
Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients. | Addiction biology 20080901 |
Drug loading and release properties of ion-exchange resin complexes as a drug delivery matrix. | International journal of pharmaceutics 20080901 |
Rheological characterization and drug release studies of gum exudates of Terminalia catappa Linn. | AAPS PharmSciTech 20080901 |
Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets. | Drug delivery 20080901 |
Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype. | Journal of clinical pharmacology 20080901 |
Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement. | Clinical therapeutics 20080901 |
Dextromethorphan abuse. | The Ceylon medical journal 20080901 |
Dextromethorphan/quinidine sulfate for pseudobulbar affect. | Drugs of today (Barcelona, Spain : 1998) 20080901 |
Dextromethorphan-induced serotonin syndrome. | Clinical toxicology (Philadelphia, Pa.) 20080901 |
Metabolite profiling in human urine by LC-MS/MS: method optimization and application for glucuronides from dextromethorphan metabolism. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080815 |
Online concentration by head-column field-amplified with large-volume sample stacking using flow injection-capillary electrophoresis for the analysis of four active components in cold medicines. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080801 |
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. | Journal of pain and symptom management 20080701 |
Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. | Drug metabolism and disposition: the biological fate of chemicals 20080701 |
Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice. | British journal of pharmacology 20080701 |
Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM). | Chemical & pharmaceutical bulletin 20080701 |
Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice. | Pakistan journal of biological sciences : PJBS 20080701 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). | Journal of medicinal chemistry 20080612 |
[Postoperative inconveniences after breast cancer surgery]. | Ugeskrift for laeger 20080602 |
[Multimodal treatment of pain and nausea in breast cancer surgery]. | Ugeskrift for laeger 20080602 |
[Dextromethorphan hydrobromide poisoning in one child]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601 |
Chronic cough. | Current opinion in supportive and palliative care 20080601 |
Development of CYP2D6 and CYP3A4 in the first year of life. | Clinical pharmacology and therapeutics 20080501 |
Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures. | British journal of clinical pharmacology 20080501 |
Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice. | Drug and alcohol dependence 20080501 |
Effect of dextromethorphan on antinociception and tolerance induced by swim-stress in the formalin test. | Archives of Iranian medicine 20080501 |
Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. | Journal of acquired immune deficiency syndromes (1999) 20080415 |
An evaluation of the genotoxicity of the antitussive drug Dextromethorphan. | Regulatory toxicology and pharmacology : RTP 20080401 |
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain. | Pharmacology, biochemistry, and behavior 20080401 |
Mechanical aspects of a multidirectional, angular stable osteosynthesis system and comparison with four conventional systems. | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20080401 |
Development and validation of ELISA and GC-MS procedures for the quantification of dextromethorphan and its main metabolite dextrorphan in urine and oral fluid. | Journal of analytical toxicology 20080401 |
High-frequency rhythmic cortical myoclonus in a long-surviving patient with nonketotic hypergylcemia. | Journal of child neurology 20080301 |
The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat. | Pest management science 20080201 |
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. | Clinical pharmacology and therapeutics 20080201 |
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. | Drug metabolism and disposition: the biological fate of chemicals 20080201 |
CYP2D6 phenotype prediction from genotype: which system is the best? | Clinical pharmacology and therapeutics 20080201 |
Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. | The European journal of neuroscience 20080201 |
Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein. | Current drug metabolism 20080201 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. | Journal of medicinal chemistry 20080124 |
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors. | Bioorganic & medicinal chemistry 20080115 |
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. | Neuroreport 20080108 |
Currently available cough suppressants for chronic cough. | Lung 20080101 |
Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101 |
Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. | Journal of pharmacological sciences 20080101 |
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. | Current drug metabolism 20080101 |
Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies. | Regional anesthesia and pain medicine 20080101 |
Dextromethorphan and quinidine combination for heroin detoxification. | The American journal on addictions 20080101 |
Oxidative phenotype status in related subjects. | Acta poloniae pharmaceutica 20080101 |
The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats. | European journal of drug metabolism and pharmacokinetics 20080101 |
Over-the-counter cough and cold medication use in young children. | Pediatric nursing 20080101 |
Coricidin HBP abuse: patient characteristics and psychiatric manifestations as recorded in an inpatient psychiatric unit. | Journal of addictive diseases 20080101 |
Ubiquitous computing for remote cardiac patient monitoring: a survey. | International journal of telemedicine and applications 20080101 |
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. | Journal of pharmacological and toxicological methods 20080101 |
Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation. | BMC neuroscience 20080101 |
Polymeric membrane sensors for the selective determination of dextromethorphan in pharmaceutical preparations. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080101 |
Use of and attitudes toward club drugs by medical students. | Journal of addictive diseases 20080101 |
Polymorphism of dextromethorphan oxidation in Polish population. | Acta poloniae pharmaceutica 20080101 |
Toxicity and use of over-the-counter cough and cold medication in the pediatric population. | Missouri medicine 20080101 |
[Evaluation of morphine metabolism in presence of amantadine and dextromethorphan in human serum by high performance liquid chromatography coupled with mass spectrometry (LC/MS) method]. | Folia medica Cracoviensia 20080101 |
e-Learning development in medical physics and engineering. | Biomedical imaging and intervention journal 20080101 |
Effect of methamphetamine on cytochrome P450 activity. | Xenobiotica; the fate of foreign compounds in biological systems 20071201 |
Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. | Archives of pediatrics & adolescent medicine 20071201 |
Effect of sodium ozagrel on the activity of rat CYP2D6. | European journal of pharmacology 20071114 |
Development of the 'Inje cocktail' for high-throughput evaluation of five human cytochrome P450 isoforms in vivo. | Clinical pharmacology and therapeutics 20071101 |
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. | Basic & clinical pharmacology & toxicology 20071101 |
Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101 |
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. | Pediatric emergency care 20071101 |
Activity of human P450 2D6 in biphasic solvent systems. | Biotechnology and bioengineering 20071001 |
Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies. | Journal of clinical pharmacology 20071001 |
A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. | Experimental neurology 20071001 |
Are false-positive phencyclidine immunoassay instant-view multi-test results caused by overdose concentrations of Ibuprofen, metamizol, and dextromethorphan? | Therapeutic drug monitoring 20071001 |
Effect of sampling procedures of release testing on drug release and scale-up production feasibility of multiple-unit dextromethorphan resinate tablets: a technical note. | AAPS PharmSciTech 20071001 |
Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070901 |
Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action. | The neurologist 20070901 |
Dextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management. | Clinical toxicology (Philadelphia, Pa.) 20070901 |
[Dangerous party drugs: A2 and cough medicines. Increasing interest among Swedish adolescents]. | Lakartidningen 20070901 |
It's nothing to laugh about: understanding disorders of emotional expression. | The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20070901 |
The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan. | European journal of pharmacology 20070827 |
Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect. | Journal of the neurological sciences 20070815 |
Modulating drug release and matrix erosion of alginate matrix capsules by microenvironmental interaction with calcium ion. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070801 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
Effects of dextromethorphan on dopamine dependent behaviours in rats. | Indian journal of experimental biology 20070801 |
Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701 |
Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations. | European biophysics journal : EBJ 20070701 |
Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies. | Journal of mass spectrometry : JMS 20070701 |
Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. | Neurotoxicology 20070701 |
Electron density analyses of opioids: a comparative study. | The journal of physical chemistry. A 20070628 |
Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615 |
Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. | European journal of pharmacology 20070614 |
Preoperative oral dextromethorphan vs. clonidine to prevent tourniquet-induced cardiovascular responses in orthopaedic patients under general anaesthesia. | European journal of anaesthesiology 20070601 |
Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601 |
Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. | Synapse (New York, N.Y.) 20070601 |
Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. | Clinical pharmacology and therapeutics 20070601 |
Separation of cold medicine ingredients using a precise MEKC method at elevated pH. | Electrophoresis 20070601 |
'Pharming': the abuse of prescription and over-the-counter drugs in teens. | Current opinion in pediatrics 20070601 |
[Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070601 |
Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6. | The American journal of geriatric pharmacotherapy 20070601 |
N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief. | Journal of medicinal chemistry 20070531 |
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. | The Journal of physiology 20070515 |
NMDA receptor antagonists: tools in neuroscience with promise for treating CNS pathologies. | The Journal of physiology 20070515 |
Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. | Journal of pharmaceutical and biomedical analysis 20070509 |
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. | Neurochemistry international 20070501 |
Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA). | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070501 |
Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. | Anesthesia and analgesia 20070501 |
'Crystal dex:' free-base dextromethorphan. | The Journal of emergency medicine 20070501 |
Dextromethorphan in Wisconsin drivers. | Journal of analytical toxicology 20070501 |
FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children? | Child health alert 20070501 |
Separation and determination of four active components in medicinal preparations by flow injection-capillary electrophoresis. | Journal of pharmaceutical and biomedical analysis 20070411 |
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats. | Psychopharmacology 20070401 |
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. | European journal of clinical pharmacology 20070401 |
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. | Clinical pharmacology and therapeutics 20070401 |
Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. | Basic & clinical pharmacology & toxicology 20070401 |
A phase III randomized, double-blind, placebo-controlled study evaluating dextromethorphan plus slow-release morphine for chronic cancer pain relief in terminally ill patients. | Journal of pain and symptom management 20070401 |
Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153. | Chemical & pharmaceutical bulletin 20070401 |
Involuntary emotional expression disorder: treating the untreated. | CNS spectrums 20070401 |
Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. | International journal of clinical pharmacology and therapeutics 20070401 |
Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study. | Haematologica 20070401 |
Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. | Respiratory physiology & neurobiology 20070315 |
Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period. | Psychopharmacology 20070301 |
Drug release properties of polymer coated ion-exchange resin complexes: experimental and theoretical evaluation. | Journal of pharmaceutical sciences 20070301 |
Possible role of pseudoephedrine and other over-the-counter cold medications in the deaths of very young children. | Journal of forensic sciences 20070301 |
Novel approach to performing metabolite identification in drug metabolism. | Journal of chromatographic science 20070301 |
Treatment of the common cold. | American family physician 20070215 |
Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis. | Journal of medicinal chemistry 20070208 |
Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application. | Journal of clinical pharmacology 20070201 |
Marketing and drug costs: who is laughing and crying? | Annals of neurology 20070201 |
Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20070117 |
A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations. | Journal of pharmaceutical and biomedical analysis 20070104 |
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. | The journal of pain : official journal of the American Pain Society 20070101 |
A placebo double-blind pilot study of dextromethorphan for problematic behaviors in children with autism. | Autism : the international journal of research and practice 20070101 |
Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population. | Clinical pharmacology and therapeutics 20070101 |
Apomorphine-induced growth hormone response is attenuated by ethanol but not dextromethorphan. | Alcoholism, clinical and experimental research 20070101 |
Reboxetine and cytochrome P450--comparison with paroxetine treatment in humans. | International journal of clinical pharmacology and therapeutics 20070101 |
Dextromethorphan premedication reduces midazolam requirement: objective and subjective parameters in peribronchoscopy. | Respiration; international review of thoracic diseases 20070101 |
Dextromethorphan: a review of N-methyl-d-aspartate receptor antagonist in the management of pain. | CNS drug reviews 20070101 |
Challenges for Australia's Bio/Nanopharma Policies: trade deals, public goods and reference pricing in sustainable industrial renewal. | Australia and New Zealand health policy 20070101 |
Efficacy of pre- and postoperative oral dextromethorphan for reduction of intra- and 24-hour postoperative morphine consumption for transabdominal hysterectomy. | Pain medicine (Malden, Mass.) 20070101 |
Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. | Arthritis research & therapy 20070101 |
Prior exposure to uninfected mosquitoes enhances mortality in naturally-transmitted West Nile virus infection. | PloS one 20070101 |
Bench-to-bedside review: mechanisms and management of hyperthermia due to toxicity. | Critical care (London, England) 20070101 |
CYP2D6 phenotyping with dextromethorphan. | Pharmacological reports : PR 20070101 |
Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. | Pediatric research 20061201 |
3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201 |
Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004. | Archives of pediatrics & adolescent medicine 20061201 |
Dextromethorphan/quinidine: a novel dextromethorphan product for the treatment of emotional lability. | Expert opinion on pharmacotherapy 20061201 |
The cost of over-the-counter substance abuse. | Journal of child and adolescent psychopharmacology 20061201 |
The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy). | Journal of psychopharmacology (Oxford, England) 20061101 |
Dextromethorphan premedication reduced postoperative analgesic consumption in patients after oral surgery. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20061101 |
The prevalence of dextromethorphan abuse among high school students. | Pediatrics 20061101 |
Beneficial effects of LK-4, an analog of dextromethorphan on lipopolysaccharide-induced sepsis in rats. | Journal of biomedical science 20061101 |
Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats. | Pharmacology, biochemistry, and behavior 20061101 |
Effects of dextromethorphan on rats' acquisition of responding with delayed reinforcement. | Pharmacology, biochemistry, and behavior 20061101 |
Modeling film-coat non-uniformity in polymer coated pellets: a stochastic approach. | International journal of pharmaceutics 20061012 |
Vanished behind the counter. Starting this week, you'll need help buying your claritin and nyquil. | U.S. news & world report 20061002 |
Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study. | Clinical therapeutics 20061001 |
Standardization of method for the analysis of dextromethorphan in urine. | Forensic science international 20060912 |
Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. | Journal of biomedical science 20060901 |
Are any cold medications safe for a person on high blood pressure medication? | Mayo Clinic women's healthsource 20060901 |
Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. | Clinical pediatrics 20060901 |
Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. | European journal of pharmacology 20060821 |
Dextromethorphan protects male but not female mice with brain ischemia. | Neuroreport 20060821 |
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3. | Biochemical and biophysical research communications 20060804 |
Expression, purification, and characterization of mouse CYP2d22. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons. | Brain research 20060630 |
Dextromethorphan-induced neurologic illness in a patient with negative toxicology findings. | Neurology 20060627 |
Pseudobulbar affect in multiple sclerosis: toward the development of innovative therapeutic strategies. | Journal of the neurological sciences 20060615 |
The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients. | The journal of pain : official journal of the American Pain Society 20060601 |
Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. | Therapeutic drug monitoring 20060601 |
Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy. | Biochemical and biophysical research communications 20060512 |
Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. | Annals of neurology 20060501 |
CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico. | Journal of clinical pharmacology 20060501 |
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail. | Journal of clinical pharmacology 20060501 |
Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. | European journal of pharmacology 20060424 |
CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. | Drug metabolism and disposition: the biological fate of chemicals 20060401 |
Efficacy, abuse, and toxicity of over-the-counter cough and cold medicines in the pediatric population. | Current opinion in pediatrics 20060401 |
Preparation and in vitro release of dual-drug resinates containing equivalent content dextromethorphan and diphenhydramine. | Drug development and industrial pharmacy 20060401 |
Simultaneous quantitation of five active principles in a pharmaceutical preparation: development and validation of a near infrared spectroscopic method. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060201 |
Repetitive dextromethorphan at adolescence affects water maze learning in female rats. | The International journal of neuroscience 20060201 |
Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism. | The Annals of pharmacotherapy 20060101 |
A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. | General hospital psychiatry 20060101 |
Index of suspicion. | Pediatrics in review 20060101 |
A qualitative systematic review of peri-operative dextromethorphan in post-operative pain. | Acta anaesthesiologica Scandinavica 20060101 |
Cluster formation as a tool for development in Medicon Valley. | IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 20060101 |
Ovariectomy ameliorates dextromethorphan--induced memory impairment in young female rats. | Journal of cellular and molecular medicine 20060101 |
Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: Beneficial effect of dextromethorphan. | Hippocampus 20060101 |
Chronic addiction to dextromethorphan cough syrup: a case report. | Journal of the American Board of Family Medicine : JABFM 20060101 |
Effect of dextromethorphan on reference memory assessed in rats by a three-panel runway task. | Arzneimittel-Forschung 20060101 |
Effects of dextromethorphan on in vitro contractile responses of mouse and rat urinary bladders. | Neurourology and urodynamics 20060101 |
Potential interactions of methylphenidate and atomoxetine with dextromethorphan. | Journal of the American Pharmacists Association : JAPhA 20060101 |
Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers. | Clinical pharmacokinetics 20060101 |
Additive effect of dextromethorphan on the inhibitory effect of anti-NT4 on morphine tolerance. | Pharmacology 20060101 |
Preoperative cotreatment with dextromethorphan and ketorolac provides an enhancement of pain relief after laparoscopic-assisted vaginal hysterectomy. | The Clinical journal of pain 20060101 |
CYP2D6 genotype and phenotype relationship in South Indians. | Journal of postgraduate medicine 20060101 |
Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan. | Lung 20060101 |
Comparative efficacy and tolerability of pholcodine and dextromethorphan in the management of patients with acute, non-productive cough : a randomized, double-blind, multicenter study. | Treatments in respiratory medicine 20060101 |
OTC product: PediaCare Long-Acting Cough Freezer Pops. | Journal of the American Pharmacists Association : JAPhA 20060101 |
OTC product: Zicam Cold and Flu Medicated Spoons. | Journal of the American Pharmacists Association : JAPhA 20060101 |
OTC product: Theraflu Thin Strips. | Journal of the American Pharmacists Association : JAPhA 20060101 |
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver. | Life sciences 20051205 |
Identification of CYP2D6 impaired functional alleles in Mexican Americans. | European journal of clinical pharmacology 20051201 |
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail. | Journal of clinical pharmacology 20051201 |
Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. | European journal of clinical pharmacology 20051201 |
Dextromethorphan psychosis, dependence and physical withdrawal. | Addiction biology 20051201 |
Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. | Clinical pharmacology and therapeutics 20051201 |
A Cadillac ride to the emergency department. | Pediatric emergency care 20051201 |
Dose-response relationship with increasing doses of dextromethorphan for children with cough. | Clinical therapeutics 20051201 |
Recombinant production of human microsomal cytochrome P450 2D6 in the methylotrophic yeast Pichia pastoris. | Chembiochem : a European journal of chemical biology 20051101 |
The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans. | Journal of clinical pharmacology 20051101 |
CYP2D6 genotype and phenotype determination in a Mexican Mestizo population. | European journal of clinical pharmacology 20051101 |
Cerebellar degeneration and folate deficiency due to cough mixture abuse. | Haematologica 20051101 |
Dextromethorphan abuse in Thai adolescents: A report of two cases and review of literature. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101 |
Enhancing the uptake of dextromethorphan in the CNS of rats by concomitant administration of the P-gp inhibitor verapamil. | Life sciences 20051021 |
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement. | The Journal of pharmacology and experimental therapeutics 20051001 |
A study of the effects of lorazepam and dextromethorphan on the response to cortical 1 Hz repetitive transcranial magnetic stimulation. | Neuroreport 20050908 |
Acute psychosis with Coricidin cold medicine. | The Annals of pharmacotherapy 20050901 |
Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis. | Journal of pharmaceutical and biomedical analysis 20050901 |
QT and QTc interval with standard and supratherapeutic doses of darifenacin, a muscarinic M3 selective receptor antagonist for the treatment of overactive bladder. | Journal of clinical pharmacology 20050901 |
Side effects of dextromethorphan abuse, a case series. | Addictive behaviors 20050901 |
Adolescent abuse of dextromethorphan. | Clinical pediatrics 20050901 |
Relieving fibromyalgia pain. An epilepsy medication and a popular cough syrup both seem to work. | Health news (Waltham, Mass.) 20050901 |
Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. | Drug metabolism and disposition: the biological fate of chemicals 20050801 |
The treatment of the behavioral sequelae of autism with dextromethorphan: a case report. | Journal of autism and developmental disorders 20050801 |
MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. | Brain research 20050719 |
Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. | Indian journal of experimental biology 20050701 |
Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD. | Journal of separation science 20050701 |
Inhibition of CYP2D6 activity by bupropion. | Journal of clinical psychopharmacology 20050601 |
Coricidin HBP cough and cold addiction. | Journal of the American Academy of Child and Adolescent Psychiatry 20050601 |
MorphiDex (morphine sulfate/dextromethorphan hydrobromide combination) in the treatment of chronic pain: three multicenter, randomized, double-blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance. | Pain 20050601 |
Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. | Biological & pharmaceutical bulletin 20050601 |
Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers. | Drug metabolism and pharmacokinetics 20050601 |
[Symptomatic treatment of painful diabetic neuropathy]. | Nihon rinsho. Japanese journal of clinical medicine 20050601 |
Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets. | AAPS PharmSciTech 20050601 |
Treatment of pseudobulbar affect in ALS: October 26 highlight and commentary. | Neurology 20050524 |
Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505 |
Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. | Proteins 20050501 |
Preincisional dextromethorphan combined with thoracic epidural anesthesia and analgesia improves postoperative pain and bowel function in patients undergoing colonic surgery. | Anesthesia and analgesia 20050501 |
Treatment of pseudobulbar affect in ALS. | The Lancet. Neurology 20050501 |
Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. | Biological & pharmaceutical bulletin 20050501 |
Effects of the N-methyl-D-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects. | The journal of pain : official journal of the American Pain Society 20050501 |
The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific. | Pharmacology, biochemistry, and behavior 20050501 |
Sol-gel-based solid-phase microextraction and gas chromatography-mass spectrometry determination of dextromethorphan and dextrorphan in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425 |
Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence? | European journal of pharmacology 20050425 |
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. | British journal of pharmacology 20050401 |
Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401 |
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. | Journal of pharmaceutical and biomedical analysis 20050401 |
NMDA antagonist modulation of morphine antinociception in female vs. male rats. | Pharmacology, biochemistry, and behavior 20050401 |
Description and validation of a four-channel staggered LC-MS/MS system for high-throughput in vitro screens. | Analytical chemistry 20050315 |
3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301 |
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain. | Synapse (New York, N.Y.) 20050301 |
Can Robitussin DM be used to treat cough during pregnancy? | Medicine and health, Rhode Island 20050301 |
Dextromethorphan-induced delirium and possible methadone interaction. | The American journal of geriatric pharmacotherapy 20050301 |
Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assay. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225 |
Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. | The Journal of pharmacology and experimental therapeutics 20050201 |
Dextromethorphan differentially affects opioid antinociception in rats. | British journal of pharmacology 20050201 |
Dextromethorphan metabolic phenotyping in an Iranian population. | European journal of clinical pharmacology 20050201 |
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect. | Pain 20050201 |
Treatment of emotional lability in ALS. | The Lancet. Neurology 20050201 |
The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. | Anesthesia and analgesia 20050201 |
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors. | Analytical chemistry 20050201 |
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. | Pediatrics 20050201 |
Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. | American journal of obstetrics and gynecology 20050201 |
Spreading depression expands traumatic injury in neocortical brain slices. | Journal of neurotrauma 20050201 |
Protective effect of dextromethorphan against endotoxic shock in mice. | Biochemical pharmacology 20050115 |
Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101 |
Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. | Rapid communications in mass spectrometry : RCM 20050101 |
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. | The pharmacogenomics journal 20050101 |
Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. | Drugs in R&D 20050101 |
[Simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension by HPLC]. | Se pu = Chinese journal of chromatography 20050101 |
High-throughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma. | European journal of mass spectrometry (Chichester, England) 20050101 |
High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs. | Journal of AOAC International 20050101 |
Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation. | Journal of AOAC International 20050101 |
Epigenetic silencing of DSC3 is a common event in human breast cancer. | Breast cancer research : BCR 20050101 |
Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats. | European journal of drug metabolism and pharmacokinetics 20050101 |
Therapeutic options for emotional lability: current and emerging treatments. | The American journal of geriatric pharmacotherapy 20050101 |
Review of pseudobulbar affect including a novel and potential therapy. | The Journal of neuropsychiatry and clinical neurosciences 20050101 |
Phenotypical expression of CYP2D6 in amerindians of tepehuano origin from Durango, Mexico. | Proceedings of the Western Pharmacology Society 20050101 |
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. | Folia medica Cracoviensia 20050101 |
Role of drug testing as an early warning programme: the experience of the Republic of Korea. | Bulletin on narcotics 20050101 |
Codeine intoxication associated with ultrarapid CYP2D6 metabolism. | The New England journal of medicine 20041230 |
LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225 |
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. | Drug metabolism and disposition: the biological fate of chemicals 20041201 |
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20041201 |
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism. | Biochemical pharmacology 20041201 |
Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH. | Journal of clinical pharmacology 20041201 |
The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain. | Anesthesia and analgesia 20041201 |
Dextromethorphan abuse. | Pediatric emergency care 20041201 |
P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. | Journal of psychopharmacology (Oxford, England) 20041201 |
Kids' cough drugs may not work. | Consumer reports 20041201 |
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. | Drug metabolism and disposition: the biological fate of chemicals 20041101 |
Bladder emptying over a period of 10-45 years after a traumatic spinal cord injury. | Spinal cord 20041101 |
Over-the-counter cough and cold medicines: should parents be using them for their children? | The Annals of pharmacotherapy 20041101 |
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. | Pediatrics 20041101 |
Oral dextromethorphan reduces perioperative analgesic administration in children undergoing tympanomastoid surgery. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20041101 |
Dextromethorphan potentiates morphine antinociception at the spinal level in rats. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20041101 |
Commentary on: Severe manifestations of coricidin intoxication. | The American journal of emergency medicine 20041101 |
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. | Neurology 20041026 |
Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers. | Journal of clinical pharmacology 20041001 |
Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs. | Journal of veterinary pharmacology and therapeutics 20041001 |
[Clinical progress of neonatal non-ketotic hyperglycinemia under treatment]. | Revista de neurologia 20041001 |
Do over-the-counter cough remedies work? | Child health alert 20041001 |
[Club drugs: old medicines as new party drugs]. | Medicina clinica 20040911 |
High-performance liquid chromatographic analysis of dextromethorphan, guaifenesin and benzoate in a cough syrup for stability testing. | Journal of chromatography. A 20040910 |
Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine. | Journal of pharmaceutical and biomedical analysis 20040903 |
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes. | Journal of pharmaceutical and biomedical analysis 20040903 |
Isobolographic analysis for combinations of a full and partial agonist: curved isoboles. | The Journal of pharmacology and experimental therapeutics 20040901 |
Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy. | Acta anaesthesiologica Scandinavica 20040901 |
Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. | Drug metabolism and disposition: the biological fate of chemicals 20040901 |
Dose-response relationship with increasing doses of dextromethorphan for children with cough. | Clinical therapeutics 20040901 |
Club drugs: reasons for and consequences of use. | Journal of psychoactive drugs 20040901 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. | Xenobiotica; the fate of foreign compounds in biological systems 20040901 |
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats. | Life sciences 20040806 |
Adverse reaction to dextromethorphan. | Allergy 20040801 |
Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking. | Journal of medicinal chemistry 20040729 |
Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens. | Forensic science international 20040716 |
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. | Journal of clinical pharmacology 20040701 |
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. | Pediatrics 20040701 |
Trends in child and teen nonprescription drug abuse reported to a regional poison control center. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040615 |
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite. | The Biochemical journal 20040601 |
Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity. | Clinica chimica acta; international journal of clinical chemistry 20040601 |
Validated assays for human cytochrome P450 activities. | Drug metabolism and disposition: the biological fate of chemicals 20040601 |
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. | Pain 20040601 |
Dextromethorphan in pain control--an old drug with new clinical application. | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040601 |
Oral slow release dextromethorphan premedication provides a pethidine spare effect on posthemorrhoidectomy pain management. | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040601 |
[Determination of dextrorphan in human plasma and pharmacokinetic study]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040601 |
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. | Behavioural brain research 20040505 |
Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure. | European journal of pharmacology 20040503 |
Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. | The Journal of pharmacology and experimental therapeutics 20040501 |
A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. | Anesthesia and analgesia 20040501 |
Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. | Xenobiotica; the fate of foreign compounds in biological systems 20040501 |
Simple chromatography method for simultaneous determination of dextromethorphan and its main metabolites in human plasma with fluorimetric detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405 |
Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan. | Bioorganic & medicinal chemistry letters 20040405 |
Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline. | British journal of clinical pharmacology 20040401 |
Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. | British journal of clinical pharmacology 20040401 |
Preoperative oral dextromethorphan attenuated tourniquet-induced arterial blood pressure and heart rate increases in knee cruciate ligament reconstruction patients under general anesthesia. | Anesthesia and analgesia 20040401 |
The use of dextromethorphan to treat repetitive self-directed scratching, biting, or chewing in dogs with allergic dermatitis. | Journal of veterinary pharmacology and therapeutics 20040401 |
Influence of concomitant quinidine administration on dextromethorphan disposition in rats. | Journal of veterinary pharmacology and therapeutics 20040401 |
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6. | Drug metabolism and disposition: the biological fate of chemicals 20040401 |
Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats. | Psychopharmacology 20040301 |
Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301 |
Dextromethorphan-associated epidural patient-controlled analgesia provides better pain- and analgesics-sparing effects than dextromethorphan-associated intravenous patient-controlled analgesia after bone-malignancy resection: a randomized, placebo-controlled, double-blinded study. | Anesthesia and analgesia 20040301 |
Analgesic effect of dextromethorphan in neuropathic pain. | Acta anaesthesiologica Scandinavica 20040301 |
Morphine potentiates dextromethorphan-induced vasodilation in rat superior mesenteric artery. | European journal of pharmacology 20040213 |
Drug abuse update: dextromethorphan. | Emergency medical services 20040201 |
Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. | Cellular and molecular neurobiology 20040201 |
Antitussive activity of sigma-1 receptor agonists in the guinea-pig. | British journal of pharmacology 20040101 |
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. | Clinical pharmacology and therapeutics 20040101 |
Poor outcome for neonatal-type nonketotic hyperglycinemia treated with high-dose sodium benzoate and dextromethorphan. | Journal of child neurology 20040101 |
Synthesis and identification of two potential oxidation degradants of oxymetazoline. | Rapid communications in mass spectrometry : RCM 20040101 |
Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but is not related to the descending serotoninergic or adrenergic pathways. | Journal of biomedical science 20040101 |
Dextromethorphan prevents circulatory failure in rats with endotoxemia. | Journal of biomedical science 20040101 |
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. | Biochemistry 20031209 |
On-line turbulent-flow chromatography-high-performance liquid chromatography-mass spectrometry for fast sample preparation and quantitation. | Journal of chromatography. A 20031205 |
Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. | Journal of clinical psychopharmacology 20031201 |
Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers. | Clinical pharmacology and therapeutics 20031201 |
Single-point plasma or urine dextromethorphan method for determining CYP3A activity. | Biopharmaceutics & drug disposition 20031201 |
Influence of methacrylic acid and hydroxypropylmethyl cellulose on the tablet properties and in vitro release of dextromethorphan hydrobromide. | Die Pharmazie 20031201 |
Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031125 |
Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. | The Journal of physiology 20031115 |
Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens. | Naunyn-Schmiedeberg's archives of pharmacology 20031101 |
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the 'Cooperstown 5+1 cocktail'. | Clinical pharmacology and therapeutics 20031101 |
A high-throughput method for enzyme kinetic studies. | Journal of biomolecular screening 20031001 |
Severe manifestations of coricidin intoxication. | The American journal of emergency medicine 20031001 |
Fatal cold medication intoxication in an infant. | Journal of analytical toxicology 20031001 |
Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. | JAMA 20030917 |
Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes. | Drug metabolism and disposition: the biological fate of chemicals 20030901 |
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes. | European journal of biochemistry 20030901 |
Sex-related differences in the enhancement of morphine antinociception by NMDA receptor antagonists in rats. | Pharmacology, biochemistry, and behavior 20030901 |
Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801 |
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. | Toxicology in vitro : an international journal published in association with BIBRA 20030801 |
Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadruple time-of-flight mass spectrometry and in-silico prediction. | Current drug metabolism 20030801 |
Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. | Clinical pharmacology and therapeutics 20030801 |
Bromide intoxication by the combination of bromide-containing over-the-counter drug and dextromethorphan hydrobromide. | Human & experimental toxicology 20030801 |
Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition. | British journal of clinical pharmacology 20030701 |
Dextromethorphan induces multifocal fixed drug eruption. | International journal of dermatology 20030601 |
Treatment of the common cold. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030601 |
Dextromethorphan prevents the diethyldithiocarbamate enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice. | Brain research 20030530 |
Determination of dextromethorphan and its metabolites in rat serum by liquid-liquid extraction and liquid chromatography with fluorescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525 |
The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat. | Brain research. Developmental brain research 20030514 |
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex. | Journal of neurophysiology 20030501 |
Dextromethorphan alters gene expression in rat brain hippocampus and cortex. | International journal of molecular medicine 20030501 |
Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
Dextromethorphan and intrathecal morphine for analgesia after Caesarean section under spinal anaesthesia. | British journal of anaesthesia 20030501 |
Preoperative and postoperative dextromethorphan provides sustained reduction in postoperative pain and patient-controlled epidural analgesia requirement: a randomized, placebo-controlled, double-blind study in lower-body bone malignancy-operated patients. | Cancer 20030501 |
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice. | Behavioural pharmacology 20030501 |
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. | The Journal of pharmacology and experimental therapeutics 20030401 |
Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships. | Clinical chemistry 20030401 |
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. | The Biochemical journal 20030315 |
New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. | Life sciences 20030307 |
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. | Pain 20030301 |
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. | Xenobiotica; the fate of foreign compounds in biological systems 20030301 |
Safety of selegiline with cold medications. | The Annals of pharmacotherapy 20030301 |
Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine. | Pharmacology, biochemistry, and behavior 20030301 |
Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex. | Brain research bulletin 20030215 |
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. | The Journal of biological chemistry 20030207 |
Determination of dextromethorphan and its metabolite dextrorphan in human urine by capillary gas chromatography without derivatization. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205 |
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. | Psychopharmacology 20030201 |
Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. | Life sciences 20030103 |
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. | Journal of medicinal chemistry 20030102 |
Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan. | Pharmacology, biochemistry, and behavior 20030101 |
Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes. | Acta pharmacologica Sinica 20030101 |
Morphine/dextromethorphan--Endo: E 3231, Morphidex. | Drugs in R&D 20030101 |
Supraspinal N-methyl-D-aspartate receptor inhibition influences the micturition reflex and function of the upper urinary tract of anesthetized and conscious rats. | Neurourology and urodynamics 20030101 |
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test. | European journal of pain (London, England) 20030101 |
Total and corrected antioxidant capacity in hemodialyzed patients. | BMC nephrology 20030101 |
Analysis of pharmacokinetic parameters for assessment of dextromethorphan metabolic phenotypes. | Journal of biomedical science 20030101 |
Bridging sectors. Medicon Valley. | Nature 20021212 |
Biotechnology in the Medicon Valley. | Nature 20021212 |
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. | Pharmacology, biochemistry, and behavior 20021201 |
Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. | Drug metabolism and disposition: the biological fate of chemicals 20021201 |
Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms. | The Journal of pharmacology and experimental therapeutics 20021201 |
Consultation with the specialist: the central serotonin syndrome: paradigm for psychotherapeutic misadventure. | Pediatrics in review 20021201 |
An informal discussion of emergency nurses' current clinical practice: what's new and what works. | Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20021201 |
Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells. | Drug metabolism and disposition: the biological fate of chemicals 20021101 |
Effect of the low-affinity, noncompetitive N-methyl-d-aspartate receptor antagonist dextromethorphan on visceral perception in healthy volunteers. | Alimentary pharmacology & therapeutics 20021101 |
Venous malformations associated with central pain: report of a case. | Anesthesia and analgesia 20021101 |
Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. | Journal of clinical pharmacology 20021101 |
Spreading depression: imaging and blockade in the rat neocortical brain slice. | Journal of neurophysiology 20021101 |
[Dextromethorphan poisoning]. | Anales espanoles de pediatria 20021101 |
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells. | Xenobiotica; the fate of foreign compounds in biological systems 20021101 |
Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine. | European journal of pharmacology 20021025 |
Simultaneous determination of dextromethorphan, diphenhydramine and phenylephrine in expectorant and decongestant syrups by capillary electrophoresis. | Journal of pharmaceutical and biomedical analysis 20021015 |
N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia. | The Journal of pharmacology and experimental therapeutics 20021001 |
Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. | Brain : a journal of neurology 20021001 |
Mechanisms influencing acquisition and recall of motor memories. | Journal of neurophysiology 20021001 |
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. | Journal of cardiac failure 20021001 |
Is cytochrome P450 CYP2D activity present in pig liver? | Pharmacology & toxicology 20021001 |
Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation. | The Journal of physiology 20020901 |
Dextromethorphan for the reduction of immediate and late postoperative pain and morphine consumption in orthopedic oncology patients: a randomized, placebo-controlled, double-blind study. | Cancer 20020901 |
[Dextromethorphane intoxication under co-medication with cytochrome P450-inhibitor fluoxetin: prolonged and accentuated signs of intoxication]. | Psychiatrische Praxis 20020901 |
Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias. | Methods and findings in experimental and clinical pharmacology 20020901 |
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. | European journal of pharmacology 20020823 |
A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. | Journal of pharmaceutical and biomedical analysis 20020822 |
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. | Journal of medicinal chemistry 20020815 |
Magnetic resonance spectroscopy study of glycine pathways in nonketotic hyperglycinemia. | Pediatric research 20020801 |
Effects of methylprednisolone and dextromethorphan on lipid peroxidation in an experimental model of spinal cord injury. | Neurosurgical review 20020801 |
CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6. | Pharmacotherapy 20020801 |
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. | Life sciences 20020726 |
A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients. | Drug and alcohol dependence 20020701 |
Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. | Clinical pharmacology and therapeutics 20020701 |
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan. | Brain research 20020628 |
Reduced (+/-)-3,4-methylenedioxymethamphetamine ('Ecstasy') metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. | Biochemical pharmacology 20020615 |
Inhibition kinetics of monoclonal antibodies against cytochromes P450. | Drug metabolism and disposition: the biological fate of chemicals 20020601 |
Dextromethorphan reduces immediate and late postoperative analgesic requirements and improves patients' subjective scorings after epidural lidocaine and general anesthesia. | Anesthesia and analgesia 20020601 |
A possible trend suggesting increased abuse from Coricidin exposures reported to the Texas Poison Network: comparing 1998 to 1999. | Veterinary and human toxicology 20020601 |
Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. | British journal of clinical pharmacology 20020601 |
Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder. | Anesthesiology 20020601 |
Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder. | Anesthesiology 20020601 |
Semi-automated liquid--liquid back-extraction in a 96-well format to decrease sample preparation time for the determination of dextromethorphan and dextrorphan in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020525 |
Effect of low-affinity NMDA receptor antagonists on electrical activity in mouse cortical slices. | European journal of pharmacology 20020517 |
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine. | Drug metabolism and disposition: the biological fate of chemicals 20020501 |
Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. | Anesthesiology 20020501 |
Biotechnology in the Medicon Valley. | Nature biotechnology 20020501 |
The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. | Journal of clinical pharmacology 20020501 |
The promise of N-methyl-D-aspartate receptor antagonists in fibromyalgia. | Rheumatic diseases clinics of North America 20020501 |
Modulation of human corticomotor excitability by somatosensory input. | The Journal of physiology 20020415 |
Analgesic effects of dextromethorphan and morphine in patients with chronic pain. | Pain 20020401 |
Selective suppression of late laryngeal adductor responses by N-methyl-D-aspartate receptor blockade in the cat. | Journal of neurophysiology 20020301 |
CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. | Clinical pharmacology and therapeutics 20020301 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. | Biochemical pharmacology 20020301 |
Is glutamate involved in transient lower esophageal sphincter relaxations? | Digestive diseases and sciences 20020301 |
EN-3231. Endo Pharmaceuticals. | Current opinion in investigational drugs (London, England : 2000) 20020301 |
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. | The Journal of pharmacology and experimental therapeutics 20020201 |
Development of a rapid and sensitive high-performance liquid chromatographic method to determine CYP2D6 phenotype in human liver microsomes. | Biomedical chromatography : BMC 20020201 |
Glutamate-induced excitotoxicity in retina: neuroprotection with receptor antagonist, dextromethorphan, but not with calcium channel blockers. | Neurochemical research 20020201 |
Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man. | Pharmacology & toxicology 20020201 |
Cytochrome p450 assays. | Current protocols in pharmacology 20020201 |
Common drugs, used in combination, may pose risk. | Report on medical guidelines & outcomes research 20020125 |
Dextromethorphan can produce false positive phencyclidine testing with HPLC. | The American journal of emergency medicine 20020101 |
Effect of ketamine, dextromethorphan, and MK-801 on cochlear dysfunction induced by transient ischemia. | The Annals of otology, rhinology, and laryngology 20020101 |
Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation. | Journal of clinical pharmacology 20020101 |
The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. | Clinical pharmacology and therapeutics 20020101 |
Prediction models in the design of neural network based ECG classifiers: a neural network and genetic programming approach. | BMC medical informatics and decision making 20020101 |
Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. | Pediatric hematology and oncology 20020101 |
Dextromethorphan for phantom pain attenuation in cancer amputees: a double-blind crossover trial involving three patients. | The Clinical journal of pain 20020101 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. | Acta anaesthesiologica Belgica 20020101 |
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein. | Archives of biochemistry and biophysics 20011201 |
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. | Chemical research in toxicology 20011201 |
CYP2D6 polymorphism in a Mexican American population. | Clinical pharmacology and therapeutics 20011201 |
Different job demands of nightshifts in hospitals. | Journal of human ergology 20011201 |
Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats. | European journal of pharmacology 20011109 |
Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. | Life sciences 20011005 |
Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. | Chest 20011001 |
St. John's wort: effect on CYP2D6 activity using dextromethorphan-dextrorphan ratios. | Journal of clinical psychopharmacology 20011001 |
Abuse of Coricidin HBP cough & cold tablets: episodes recorded by a poison center. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011001 |
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. | Clinical pharmacology and therapeutics 20011001 |
Dextromethorphan in pregnancy. | Chest 20010901 |
Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats. | Neuroscience letters 20010824 |
Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. | Pharmacogenetics 20010801 |
Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California. | Pharmacogenetics 20010801 |
The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humans. | Psychopharmacology 20010801 |
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain. | The European journal of surgery = Acta chirurgica 20010801 |
Combined pre-incisional oral dextromethorphan and epidural lidocaine for postoperative pain reduction and morphine sparing: a randomised double-blind study on day-surgery patients. | Anaesthesia 20010701 |
NMDA receptor-mediated modulation of ventilation in obese Zucker rats. | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20010701 |
Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan. | Journal of clinical pharmacology 20010701 |
Increasing bioanalytical throughput using pcSFC-MS/MS: 10 minutes per 96-well plate. | Analytical chemistry 20010701 |
Improved postoperative pain control in pediatric adenotonsillectomy with dextromethorphan. | The Laryngoscope 20010701 |
[Work time distribution in night shift: are clinics facing a adjustment boom?]. | Pflege Zeitschrift 20010701 |
Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats. | European journal of pharmacology 20010629 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. | European journal of pharmacology 20010629 |
Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity. | Life sciences 20010629 |
Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats. | European journal of pharmacology 20010622 |
Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test. | Therapeutic drug monitoring 20010601 |
Cold-syrup induced movement disorder. | Pediatric emergency care 20010601 |
Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. | Behavioural brain research 20010501 |
Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr. | Journal of clinical pharmacology 20010501 |
Dextromethorphan is an effective cough suppressant. | The Journal of emergency medicine 20010501 |
An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19. | European journal of clinical pharmacology 20010501 |
Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6. | The Biochemical journal 20010415 |
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. | Journal of chromatography. B, Biomedical sciences and applications 20010415 |
Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. | Drug metabolism and disposition: the biological fate of chemicals 20010401 |
Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe. | Journal of clinical pharmacology 20010401 |
Angle closure risk from proprietary medicines. | Eye (London, England) 20010401 |
Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation. | Drug metabolism and disposition: the biological fate of chemicals 20010301 |
The effect of the preemptive use of the NMDA receptor antagonist dextromethorphan on postoperative analgesic requirements. | Anesthesia and analgesia 20010301 |
Large-dose oral dextromethorphan as an adjunct to patient-controlled analgesia with morphine after knee surgery. | Anesthesia and analgesia 20010201 |
The safety of dextromethorphan in pregnancy : results of a controlled study. | Chest 20010201 |
Dextromethorphan attenuation of postoperative pain and primary and secondary thermal hyperalgesia. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010201 |
Estimation of the percolation thresholds in dextromethorphan hydrobromide matrices. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201 |
Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. | British journal of clinical pharmacology 20010201 |
Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers. | British journal of clinical pharmacology 20010201 |
Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation. | Journal of clinical pharmacology 20010101 |
Terbinafine-associated inhibition of dextromethorphan metabolism in Chinese subjects. | British journal of clinical pharmacology 20010101 |
Epidemiologic analysis of prenatal exposure to cough medicines containing dextromethorphan: no evidence of human teratogenicity. | Teratology 20010101 |
Separation of cold medicine ingredients by capillary electrophoresis. | Electrophoresis 20010101 |
Dextromethorphan and ecstasy pills. | JAMA 20010101 |
The effect of the NMDA receptor blocker, dextromethorphan, on cribbing in horses. | Pharmacology, biochemistry, and behavior 20010101 |
Genetic polymorphism of CYP2D6 in Tamil population. | European journal of clinical pharmacology 20010101 |
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. | Rapid communications in mass spectrometry : RCM 20010101 |
The placebo response to citric acid-induced cough: pharmacodynamics and gender differences. | Pulmonary pharmacology & therapeutics 20010101 |
The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects. | Toxicology in vitro : an international journal published in association with BIBRA 20010101 |
The role of glutamatergic transmission in the pathogenesis of levodopa-induced dyskinesias. Potential therapeutic approaches. | Neurologia i neurochirurgia polska 20010101 |
Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. | The Journal of pharmacology and experimental therapeutics 20000601 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. | British journal of clinical pharmacology 20000401 |
The antitussive activity of delta-opioid receptor stimulation in guinea pigs. | The Journal of pharmacology and experimental therapeutics 20000201 |
Mimicking gene defects to treat drug dependence. | Annals of the New York Academy of Sciences 20000101 |
Acute abstinence syndrome following abrupt cessation of long-term use of tramadol (Ultram): a case study. | European journal of pain (London, England) 20000101 |
[Acute cholestatic hepatitis induced by dextromethorphan]. | Gastroenterologia y hepatologia 19991001 |
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice. | European journal of pharmacology 19990714 |
Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. | The Journal of pharmacology and experimental therapeutics 19990401 |
Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. | Brain research 19990313 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. | General pharmacology 19990301 |
Dextromethorphan- and pseudoephedrine-induced agitated psychosis and ataxia: case report. | The Journal of emergency medicine 19990101 |
Preoperative dextromethorphan reduces intraoperative but not postoperative morphine requirements after laparotomy. | Anesthesia and analgesia 19981101 |
Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease. | Neurology 19980701 |
[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan]. | Schweizerische medizinische Wochenschrift 19980207 |
CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication. | Pharmacogenetics 19971201 |
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism. | Pharmacogenetics 19971201 |
Effects of dextromethorphan in clinical doses on capsaicin-induced ongoing pain and mechanical hypersensitivity. | Journal of pain and symptom management 19971001 |
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat. | Brain research 19970509 |
Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients. | Psychiatry research 19970324 |
NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology. | The Journal of pharmacology and experimental therapeutics 19970201 |
Acute dystonia following standard doses of a cold medicine containing phenylpropanolamine. | Clinical pediatrics 19970101 |
Dextromethorphan-induced mania. | Psychosomatics 19960101 |
Acute dystonia in a child associated with therapeutic ingestion of a dextromethorphan containing cough and cold syrup. | Journal of toxicology. Clinical toxicology 19960101 |
Pharmacological profile of dextrorphan. | Arzneimittel-Forschung 19951101 |
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. | The Journal of pharmacology and experimental therapeutics 19950901 |
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. | Archives of biochemistry and biophysics 19950601 |
Cognitive deterioration from long-term abuse of dextromethorphan: a case report. | Journal of psychiatry & neuroscience : JPN 19941101 |
The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. | The American journal of emergency medicine 19941101 |
Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. | Acta neurochirurgica. Supplementum 19940101 |
Comparative effects of felbamate and other compounds on N-methyl-D-aspartic acid-induced convulsions and lethality in mice. | Pharmacological research 19940101 |
Visual hallucinations after combining fluoxetine and dextromethorphan. | The American journal of psychiatry 19921001 |
Dextromethorphan and high-dose benzoate therapy for nonketotic hyperglycinemia in an infant. | The Journal of pediatrics 19920701 |
The need for rational therapeutics in the use of cough and cold medicine in infants. | Pediatrics 19920401 |
Differential effects of morphinan drugs on haloperidol-induced catalepsy in rats: a comparative study with an N-methyl-D-aspartate antagonist. | Archives internationales de pharmacodynamie et de therapie 19910101 |
Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. | Journal of pharmaceutical sciences 19901201 |
Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats. | British journal of pharmacology 19901101 |
Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant. | Hepatology (Baltimore, Md.) 19890801 |
Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. | Science (New York, N.Y.) 19890616 |
Dextromethorphan does not protect against quinolinic acid neurotoxicity in rat striatum. | Neuroscience letters 19881219 |
Paranoid psychoses after abuse of proprietary cold remedies. | The British journal of psychiatry : the journal of mental science 19871001 |
Objective evaluation of dextromethorphan and glaucine as antitussive agents. | British journal of clinical pharmacology 19840501 |
Effect of the centrally acting antitussives on ascites tumor cells. | Japanese journal of pharmacology 19830401 |