Home Other Building Blocks Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-

Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-

CAS No.:
125-71-3
Catalog Number:
AG000MZ9
Molecular Formula:
C18H25NO
Molecular Weight:
271.3972
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
1 week
United States
$73
- +
5g
1 week
United States
$100
- +
25g
1 week
United States
$246
- +
100g
1 week
United States
$663
- +
Product Description
Catalog Number:
AG000MZ9
Chemical Name:
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
CAS Number:
125-71-3
Molecular Formula:
C18H25NO
Molecular Weight:
271.3972
MDL Number:
MFCD00866833
IUPAC Name:
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
InChI:
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
InChI Key:
MKXZASYAUGDDCJ-NJAFHUGGSA-N
SMILES:
COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C
UNII:
7355X3ROTS
Properties
Complexity:
370  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
271.194g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
271.404g/mol
Monoisotopic Mass:
271.194g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
12.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4  
Literature
Title Journal
MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor. Toxicology and applied pharmacology 20171101
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine. Chemico-biological interactions 20170601
In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. Toxicology in vitro : an international journal published in association with BIBRA 20170401
Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicology letters 20160122
Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20140101
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicology in vitro : an international journal published in association with BIBRA 20130901
The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. Toxicology in vitro : an international journal published in association with BIBRA 20130801
Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. Journal of applied toxicology : JAT 20130201
Dextromethorphan-induced psychotoxic behaviors cause sexual dysfunction in male mice via stimulation of σ-1 receptors. Neurochemistry international 20121101
Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson's disease: role of NMDA vs. 5-HT1A receptors. The European journal of neuroscience 20121101
Liquid chromatography/quadrupole-time-of-flight mass spectrometry with metabolic profiling of human urine as a tool for environmental analysis of dextromethorphan. Journal of chromatography. A 20121012
Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization in rats. Synapse (New York, N.Y.) 20121001
Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing. International journal of clinical pharmacology and therapeutics 20121001
High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. Psychopharmacology 20120901
Dextromethorphan abuse leading to assault, suicide, or homicide. Journal of forensic sciences 20120901
Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901
Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120901
Viscerosomatic facilitation in a subset of IBS patients, an effect mediated by N-methyl-D-aspartate receptors. The journal of pain : official journal of the American Pain Society 20120901
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. Journal of clinical pharmacology 20120801
Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan. Drug development and industrial pharmacy 20120801
Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice. Journal of clinical pharmacy and therapeutics 20120801
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection. Journal of viral hepatitis 20120801
Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. Therapeutic drug monitoring 20120801
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance. Drug metabolism and disposition: the biological fate of chemicals 20120701
Introduction to the special issue on 'Advances in Biomedical Engineering and Computing: the MEDICON Conference Case' selected papers from MEDICON 2010. Computer methods and programs in biomedicine 20120701
Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615
Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers. Xenobiotica; the fate of foreign compounds in biological systems 20120601
An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan. Medical hypotheses 20120601
Mechanism-based CYP2D6 inactivation by acridone alkaloids of Indonesian medicinal plant Lunasia amara. Fitoterapia 20120601
Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Die Pharmazie 20120601
Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics. Talanta 20120530
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry 20120524
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. Phytomedicine : international journal of phytotherapy and phytopharmacology 20120515
Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells. Neuroscience letters 20120510
CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population. European journal of clinical pharmacology 20120501
The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder. Journal of affective disorders 20120501
Factors that affect the diagnostic yield of endobronchial ultrasonography-assisted transbronchial lung biopsy. Journal of laparoendoscopic & advanced surgical techniques. Part A 20120501
A herbal-drug interaction study of keishi-bukuryo-gan, a traditional herbal preparation used for menopausal symptoms, in healthy female volunteers. The Journal of pharmacy and pharmacology 20120501
Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy. Journal of the Formosan Medical Association = Taiwan yi zhi 20120501
Antitussive effects of memantine in guinea pigs. Chest 20120401
The effect of dacomitinib (PF-00299804) on CYP2D6 activity in healthy volunteers who are extensive or intermediate metabolizers. Cancer chemotherapy and pharmacology 20120401
GABAA agonist reduces visual awareness: a masking-EEG experiment. Journal of cognitive neuroscience 20120401
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy 20120401
Honey for acute cough in children. The Cochrane database of systematic reviews 20120314
Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. Phytotherapy research : PTR 20120301
Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats. American journal of respiratory cell and molecular biology 20120301
Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. Clinical drug investigation 20120301
Gas chromatographic method validation for the analysis of major components in illicit heroin seized in Malaysia. Science & justice : journal of the Forensic Science Society 20120301
Repeated administration of berberine inhibits cytochromes P450 in humans. European journal of clinical pharmacology 20120201
Emphasizing the value of phenotyping in patients receiving tamoxifen. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120201
Efficacy and safety of dextromethorphan/quinidine at two dosage levels for diabetic neuropathic pain: a double-blind, placebo-controlled, multicenter study. Pain medicine (Malden, Mass.) 20120201
Preparation and evaluation of taste-masked dextromethorphan oral disintegrating tablet. Pharmaceutical development and technology 20120101
Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia. Brain & development 20120101
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole. Drug metabolism and disposition: the biological fate of chemicals 20120101
Dextromethorphan/quinidine for chorea: an open-label assessment. Clinical neuropharmacology 20120101
A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers. Clinical drug investigation 20120101
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. Biomedical research (Tokyo, Japan) 20120101
Low-dose dextromethorphan, a NADPH oxidase inhibitor, reduces blood pressure and enhances vascular protection in experimental hypertension. PloS one 20120101
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. Behavioural brain research 20111201
Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer. The FEBS journal 20111201
CYP2D6 and tamoxifen: awaiting the denouement. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111201
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer chemotherapy and pharmacology 20111101
Intentional Coricidin product exposures among Illinois adolescents. The American journal of drug and alcohol abuse 20111101
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity. Synapse (New York, N.Y.) 20111001
Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. Neurobiology of disease 20111001
Determination of dextromethorphan in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry 20111001
Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug and alcohol dependence 20110901
N-Methyl-D-aspartate receptor modulators block hyperalgesia induced by acute low-dose morphine. Clinical and experimental pharmacology & physiology 20110901
Dextromethorphan abuse in teens: beware acetaminophen poisoning! CJEM 20110901
Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820
Personalized tamoxifen: what is the best way forward? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820
Concerns about dextromethorphan as a potential rapid-acting antidepressant. Medical hypotheses 20110801
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry 20110714
Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments. Expert review of neurotherapeutics 20110701
Current concepts in the pharmacotherapy of pseudobulbar affect. Drugs 20110618
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110614
Dextromethorphan/quinidine (Nuedexta) for pseudobulbar affect. The Medical letter on drugs and therapeutics 20110613
Late-onset nonketotic hyperglycinemia caused by a novel homozygous missense mutation in the GLDC gene. Molecular genetics and metabolism 20110601
Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adduction. Drug metabolism and disposition: the biological fate of chemicals 20110601
Investigation of antitussive and toxicological activity of Ballota limbata in mice. Pharmaceutical biology 20110601
Monitoring trends in dextromethorphan abuse using the National Poison Data System: 2000-2010. Clinical toxicology (Philadelphia, Pa.) 20110601
Drug metabolism in hemorrhagic shock: pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model. The Journal of surgical research 20110515
QTc prolongation due to dextromethorphan. International journal of cardiology 20110505
Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype. Psychopharmacology 20110501
Dextromethorphan as a potential rapid-acting antidepressant. Medical hypotheses 20110501
Optimum design of experiments for enzyme inhibition kinetic models. Journal of biopharmaceutical statistics 20110501
Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. Clinical pharmacokinetics 20110501
Dextromethorphan/quinidine: in pseudobulbar affect. CNS drugs 20110501
Experience and analysis of level VII cervical lymph node metastases in patients with papillary thyroid carcinoma. Journal of the Korean Surgical Society 20110501
Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS. Analytical and bioanalytical chemistry 20110401
Molecularly imprinted polymer cartridges coupled on-line with high performance liquid chromatography for simple and rapid analysis of dextromethorphan in human plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110401
[Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401
Do cough suppressants or honey help pediatric cough? Canadian family physician Medecin de famille canadien 20110401
Developmental toxicity of dextromethorphan in zebrafish embryos/larvae. Journal of applied toxicology : JAT 20110301
Dextromethorphan abuse masquerading as a recurrent seizure disorder. Pediatric emergency care 20110301
Gene copy number variations: it is important to determine which allele is affected. Pharmacogenomics 20110301
Recommendations for the proper use of nonprescription cough suppressants and expectorants in solid-organ transplant recipients. Progress in transplantation (Aliso Viejo, Calif.) 20110301
The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine. Fundamental & clinical pharmacology 20110201
Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome. The journal of pain : official journal of the American Pain Society 20110201
Differential alterations of GABA(A) receptor (α1, β2, γ2 subunit) expression and increased seizure susceptibility in rat offspring from morphine-addicted mothers: beneficial effect of dextromethorphan. Neuroscience letters 20110201
Application of experimental design in optimization of the separation condition for determination of four active components in cold medicines by flow injection-capillary electrophoresis. Journal of chromatographic science 20110201
Dextromethorphan: abusing the overused. Singapore medical journal 20110201
[CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination]. Yao xue xue bao = Acta pharmaceutica Sinica 20110201
[CYP2D6 genotypes and phenotypes in Chinese Han, Uygur and Kazakh populations]. Yao xue xue bao = Acta pharmaceutica Sinica 20110201
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of pharmaceutical and biomedical analysis 20110125
Effect of dextromethorphan on human K(v)1.3 channel activity: involvement of C-type inactivation. European journal of pharmacology 20110125
Floating matrix dosage form for dextromethorphan hydrobromide based on gas forming technique: in vitro and in vivo evaluation in healthy volunteers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110118
Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110101
Nociceptive behavior following hindpaw burn injury in young rats: response to systemic morphine. Pain medicine (Malden, Mass.) 20110101
Serotonin syndrome induced by dextromethorphan (Medicon) administrated at the conventional dose. Geriatrics & gerontology international 20110101
Myoclonus after dextromethorphan administration in peritoneal dialysis. The Annals of pharmacotherapy 20110101
Antepartum fetal heart rate feature extraction and classification using empirical mode decomposition and support vector machine. Biomedical engineering online 20110101
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular neurodegeneration 20110101
[Pharmacokinetic study of a new chewing gum dextromethorphan delivery system]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110101
Cough syrup psychosis. CJEM 20110101
The Ti-Epiplating system as an alternative for ear prostheses in burned patients. Journal of burn care & research : official publication of the American Burn Association 20110101
Pharmacological and clinical overview of cloperastine in treatment of cough. Therapeutics and clinical risk management 20110101
Dextromethorphan inhibits the glutamatergic synaptic transmission in the nucleus tractus solitarius of guinea pigs. Journal of pharmacological sciences 20110101
Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. Journal of pharmacological sciences 20110101
Simultaneous determination of dextromethorphan and its metabolite dextrorphan in plasma samples using second-order calibration coupled with excitation-emission matrix fluorescence. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101
Dextromethorphan abuse in Texas, 2000-2009. Journal of addictive diseases 20110101
Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757. Pharmacology 20110101
Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. Journal of biomedical science 20110101
Knowledge, attitudes and practices of health professionals and women towards medication use in breastfeeding: A review. International breastfeeding journal 20110101
[Clinical practice guidelines in dextromethorphan poisoning pre-hospital management]. Przeglad lekarski 20110101
Use of CNS medications and cognitive decline in the aged: a longitudinal population-based study. BMC geriatrics 20110101
Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury. TheScientificWorldJournal 20110101
Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats. Neuro endocrinology letters 20110101
Evaluation of the reinforcing and subjective effects of heroin in combination with dextromethorphan and quinidine. Journal of opioid management 20110101
Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review. British journal of clinical pharmacology 20101201
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases. Journal of medicinal chemistry 20101125
Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Annals of neurology 20101101
Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. Clinical pharmacology and therapeutics 20101101
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Pharmacogenetics and genomics 20101101
Advisers vote against declaring dextromethorphan a controlled substance. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101101
Comparative evaluation of ten different condylar base fracture osteosynthesis techniques. The British journal of oral & maxillofacial surgery 20101001
Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population. European journal of clinical pharmacology 20101001
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica 20101001
Neuropsychopharmacological understanding for therapeutic application of morphinans. Archives of pharmacal research 20101001
On-line drug metabolites generation and their subsequent target analysis by capillary zone electrophoresis with UV-absorption detection. Electrophoresis 20101001
Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. European journal of clinical pharmacology 20100901
Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan. Drug metabolism and disposition: the biological fate of chemicals 20100901
Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats. Hypertension research : official journal of the Japanese Society of Hypertension 20100901
Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer prevention research (Philadelphia, Pa.) 20100901
Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes. Drug testing and analysis 20100901
Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets. Acta pharmaceutica (Zagreb, Croatia) 20100901
Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomedical chromatography : BMC 20100801
Co-administration of dextromethorphan and morphine: reduction of post-operative pain and lack of influence on morphine metabolism. Basic & clinical pharmacology & toxicology 20100801
Impact of the voluntary withdrawal of over-the-counter cough and cold medications on pediatric ingestions reported to poison centers. Pharmacoepidemiology and drug safety 20100801
In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. Journal of ethnopharmacology 20100720
A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. Journal of alternative and complementary medicine (New York, N.Y.) 20100701
Dextromethorphan withdrawal and dependence syndrome. Deutsches Arzteblatt international 20100701
LC for analysis of two sustained-release mixtures containing cough cold suppressant drugs. Journal of chromatographic science 20100701
L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100505
Variability in drug metabolizing enzyme activity in HIV-infected patients. European journal of clinical pharmacology 20100501
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501
[Comparison of port needle with safety device between Huber Plus (HP) and Poly PERF Safe (PPS)]. Gan to kagaku ryoho. Cancer & chemotherapy 20100501
Carbon paste and PVC electrodes for the flow injection potentiometric determination of dextromethorphan. Talanta 20100415
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain. IDrugs : the investigational drugs journal 20100401
Coadministration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertility and sterility 20100315
Evaluation of the analgesic effect of dextromethorphan and its interaction with nitric oxide on sciatic nerve ligated rats. Journal of acupuncture and meridian studies 20100301
Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats. Toxicology and industrial health 20100201
Test compounds for detecting the silanol effect on the elution of ionized amines in reversed-phase LC. Journal of separation science 20100201
Preoperative oral dextromethorphan does not reduce pain or morphine consumption after open cholecystectomy. Middle East journal of anaesthesiology 20100201
Honey for acute cough in children. The Cochrane database of systematic reviews 20100120
Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4. Chemico-biological interactions 20100105
NMR studies of dextromethorphan in both isotropic and anisotropic states. Chirality 20100101
Urinary incontinence in spinal cord injured individuals 10-45 years after injury. Spinal cord 20100101
Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Human psychopharmacology 20100101
Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. PloS one 20100101
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug metabolism letters 20100101
Association of circulating angiotensin converting enzyme activity with respiratory muscle function in infants. Respiratory research 20100101
Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos. Pharmacology 20100101
Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature. Drug metabolism and pharmacokinetics 20100101
Multivariate optimization and validation of a capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromur, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate in a pharmaceutical preparation using response surface methodology. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101
Flexible Macroblock Ordering for Context-Aware Ultrasound Video Transmission over Mobile WiMAX. International journal of telemedicine and applications 20100101
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? Antiviral therapy 20100101
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacology, biochemistry, and behavior 20091201
[Removal of metallic foreign body in the soft tissue under fluoroscopy: 10 years of experiences]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091201
[Serotonin syndrome caused by an overdose of dextromethorphan, Medicon]. Masui. The Japanese journal of anesthesiology 20091201
A 60-year-old woman with agitation and psychosis following ingestion of dextromethorphan and opioid analgesics. Journal of psychopharmacology (Oxford, England) 20091101
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. Biomedical chromatography : BMC 20091101
Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury. Pharmacology, biochemistry, and behavior 20091101
(13)C breath tests in personalized medicine: fiction or reality? Expert review of molecular diagnostics 20091101
Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats. Canadian journal of physiology and pharmacology 20091101
Effects of drugs and drug combinations in pigeons trained to discriminate among pentobarbital, dizocilpine, a combination of these drugs, and saline. Journal of the experimental analysis of behavior 20091101
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers. Basic & clinical pharmacology & toxicology 20091001
Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management. Current opinion in anaesthesiology 20091001
Effects of dextromethorphan/quinidine on auditory event-related potentials in multiple sclerosis patients with pseudobulbar affect. Journal of clinical psychopharmacology 20091001
Do OTC remedies relieve cough in acute URIs? The Journal of family practice 20091001
A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. Brain research 20090908
Combined dextromethorphan and chlorpheniramine intoxication in impaired drivers. Journal of forensic sciences 20090901
Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects. Psychiatria Danubina 20090901
Best drugs for what ails you: the brands to buy--and those to skip. Consumer reports 20090901
Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801
CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis. Drug metabolism and disposition: the biological fate of chemicals 20090801
Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans. Drug metabolism and disposition: the biological fate of chemicals 20090701
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? Pain 20090701
Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochemistry international 20090701
A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090601
Cough in the palliative care setting. Canadian family physician Medecin de famille canadien 20090601
Screening of codeine, dextromethorphan & dextropropoxyphene for their genotoxicity in Swiss albino mice. The Indian journal of medical research 20090601
Simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography. Talanta 20090515
Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds. Bioorganic & medicinal chemistry 20090501
[Fever induced by various drugs]. Rinsho byori. The Japanese journal of clinical pathology 20090501
Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays. Journal of medicinal chemistry 20090423
Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese. Drug metabolism and disposition: the biological fate of chemicals 20090401
Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice. Cardiovascular research 20090401
Overdose in infant caused by over-the-counter cough medicine. Southern medical journal 20090401
A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Therapeutic drug monitoring 20090401
Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol. Biochemical pharmacology 20090301
Five deaths resulting from abuse of dextromethorphan sold over the internet. Journal of analytical toxicology 20090301
[Bone anchored hearing aids (BAHA)]. HNO 20090301
Dextromethorphan hydrobromide preparations on the Belgian market--a comparative study. Journal de pharmacie de Belgique 20090301
Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. Journal of pharmaceutical sciences 20090201
The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction. The pharmacogenomics journal 20090201
Effects of dextromethorphan on electroconvulsive therapy. Psychiatry and clinical neurosciences 20090201
Pre-emptive oral dextromethorphan reduces both postoperative and packing removal pain in patients undergoing nasal surgery. Saudi medical journal 20090201
Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. European journal of clinical pharmacology 20090101
Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain : a journal of neurology 20090101
Characterization of retrieved orthodontic miniscrew implants. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20090101
Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment. British journal of clinical pharmacology 20090101
Amyotrophic lateral sclerosis. Orphanet journal of rare diseases 20090101
The diagnostic role of glycosaminoglycans in pleural effusions: a pilot study. BMC pulmonary medicine 20090101
Effect of fenofibrate on microcirculation and wound healing in healthy and diabetic mice. European journal of medical research 20090101
Dextromethorphan abuse: clinical effects and management. Journal of the American Pharmacists Association : JAPhA 20090101
Retrospective analysis of titanium plate-retained prostheses placed after total rhinectomy. The International journal of oral & maxillofacial implants 20090101
O-demethylation of dextromethorphan using microbial cultures. Drug metabolism letters 20090101
Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. PloS one 20090101
Ultra-fast and optimized method for the preparation of rodent testicular cells for flow cytometric analysis. Biological procedures online 20090101
Re: Myocardial infarction associated with Adderall XR and alcohol use in a young man. Journal of the American Board of Family Medicine : JABFM 20090101
Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. Journal of biomedical science 20090101
Intersexual differences in inhibitory influence of trans-resveratrol on activity of cytochrome P450 2D2 in rats. Neuro endocrinology letters 20090101
[Acute dextromethorphan poisoning based on the records of the Department of Toxicology and Internal Diseases in Poznan]. Przeglad lekarski 20090101
Implant-retained craniofacial prostheses for facial defects. GMS current topics in otorhinolaryngology, head and neck surgery 20090101
Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug metabolism and disposition: the biological fate of chemicals 20081201
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals 20081201
Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201
Comment on 'Dextromethorphan-induced serotonin syndrome'. Clinical toxicology (Philadelphia, Pa.) 20081201
Accidental dextromethorphan ingestions in children less than 5 years old. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201
'DXemon juice:' analytical evaluation of an extraction process for the purification and freebasing of dextromethorphan from cold preparations. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201
Effects of common antitussive drugs on the hERG potassium channel current. Journal of cardiovascular pharmacology 20081201
A teenager with focal weakness. Pediatric emergency care 20081201
In vitro metabolism studies of new adenosine A 2A receptor antagonists. Drug metabolism letters 20081201
sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons. The Journal of pharmacology and experimental therapeutics 20081101
The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition. Drug metabolism and disposition: the biological fate of chemicals 20081101
Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats. The Chinese journal of physiology 20081031
Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers. Journal of thrombosis and haemostasis : JTH 20081001
Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochemical pharmacology 20081001
The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans. Journal of clinical psychopharmacology 20081001
N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. Journal of neurosurgical anesthesiology 20081001
Dextromethorphan. Annals of the New York Academy of Sciences 20081001
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. Journal of pharmaceutical and biomedical analysis 20080910
Effects of repeated cycles of sterilisation on the mechanical characteristics of titanium miniplates for osteosynthesis. The British journal of oral & maxillofacial surgery 20080901
Tramadol for pain relief in children undergoing adenotonsillectomy: a comparison with dextromethorphan. The Laryngoscope 20080901
Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients. Addiction biology 20080901
Drug loading and release properties of ion-exchange resin complexes as a drug delivery matrix. International journal of pharmaceutics 20080901
Rheological characterization and drug release studies of gum exudates of Terminalia catappa Linn. AAPS PharmSciTech 20080901
Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets. Drug delivery 20080901
Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype. Journal of clinical pharmacology 20080901
Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement. Clinical therapeutics 20080901
Dextromethorphan abuse. The Ceylon medical journal 20080901
Dextromethorphan/quinidine sulfate for pseudobulbar affect. Drugs of today (Barcelona, Spain : 1998) 20080901
Dextromethorphan-induced serotonin syndrome. Clinical toxicology (Philadelphia, Pa.) 20080901
Metabolite profiling in human urine by LC-MS/MS: method optimization and application for glucuronides from dextromethorphan metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080815
Online concentration by head-column field-amplified with large-volume sample stacking using flow injection-capillary electrophoresis for the analysis of four active components in cold medicines. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080801
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. Journal of pain and symptom management 20080701
Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. Drug metabolism and disposition: the biological fate of chemicals 20080701
Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice. British journal of pharmacology 20080701
Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM). Chemical & pharmaceutical bulletin 20080701
Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice. Pakistan journal of biological sciences : PJBS 20080701
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
[Postoperative inconveniences after breast cancer surgery]. Ugeskrift for laeger 20080602
[Multimodal treatment of pain and nausea in breast cancer surgery]. Ugeskrift for laeger 20080602
[Dextromethorphan hydrobromide poisoning in one child]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
Chronic cough. Current opinion in supportive and palliative care 20080601
Development of CYP2D6 and CYP3A4 in the first year of life. Clinical pharmacology and therapeutics 20080501
Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures. British journal of clinical pharmacology 20080501
Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice. Drug and alcohol dependence 20080501
Effect of dextromethorphan on antinociception and tolerance induced by swim-stress in the formalin test. Archives of Iranian medicine 20080501
Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. Journal of acquired immune deficiency syndromes (1999) 20080415
An evaluation of the genotoxicity of the antitussive drug Dextromethorphan. Regulatory toxicology and pharmacology : RTP 20080401
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain. Pharmacology, biochemistry, and behavior 20080401
Mechanical aspects of a multidirectional, angular stable osteosynthesis system and comparison with four conventional systems. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20080401
Development and validation of ELISA and GC-MS procedures for the quantification of dextromethorphan and its main metabolite dextrorphan in urine and oral fluid. Journal of analytical toxicology 20080401
High-frequency rhythmic cortical myoclonus in a long-surviving patient with nonketotic hypergylcemia. Journal of child neurology 20080301
The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat. Pest management science 20080201
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clinical pharmacology and therapeutics 20080201
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug metabolism and disposition: the biological fate of chemicals 20080201
CYP2D6 phenotype prediction from genotype: which system is the best? Clinical pharmacology and therapeutics 20080201
Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. The European journal of neuroscience 20080201
Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein. Current drug metabolism 20080201
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry 20080124
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors. Bioorganic & medicinal chemistry 20080115
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Neuroreport 20080108
Currently available cough suppressants for chronic cough. Lung 20080101
Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101
Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. Journal of pharmacological sciences 20080101
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. Current drug metabolism 20080101
Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies. Regional anesthesia and pain medicine 20080101
Dextromethorphan and quinidine combination for heroin detoxification. The American journal on addictions 20080101
Oxidative phenotype status in related subjects. Acta poloniae pharmaceutica 20080101
The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats. European journal of drug metabolism and pharmacokinetics 20080101
Over-the-counter cough and cold medication use in young children. Pediatric nursing 20080101
Coricidin HBP abuse: patient characteristics and psychiatric manifestations as recorded in an inpatient psychiatric unit. Journal of addictive diseases 20080101
Ubiquitous computing for remote cardiac patient monitoring: a survey. International journal of telemedicine and applications 20080101
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. Journal of pharmacological and toxicological methods 20080101
Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation. BMC neuroscience 20080101
Polymeric membrane sensors for the selective determination of dextromethorphan in pharmaceutical preparations. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080101
Use of and attitudes toward club drugs by medical students. Journal of addictive diseases 20080101
Polymorphism of dextromethorphan oxidation in Polish population. Acta poloniae pharmaceutica 20080101
Toxicity and use of over-the-counter cough and cold medication in the pediatric population. Missouri medicine 20080101
[Evaluation of morphine metabolism in presence of amantadine and dextromethorphan in human serum by high performance liquid chromatography coupled with mass spectrometry (LC/MS) method]. Folia medica Cracoviensia 20080101
e-Learning development in medical physics and engineering. Biomedical imaging and intervention journal 20080101
Effect of methamphetamine on cytochrome P450 activity. Xenobiotica; the fate of foreign compounds in biological systems 20071201
Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Archives of pediatrics & adolescent medicine 20071201
Effect of sodium ozagrel on the activity of rat CYP2D6. European journal of pharmacology 20071114
Development of the 'Inje cocktail' for high-throughput evaluation of five human cytochrome P450 isoforms in vivo. Clinical pharmacology and therapeutics 20071101
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals 20071101
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic & clinical pharmacology & toxicology 20071101
Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Pediatric emergency care 20071101
Activity of human P450 2D6 in biphasic solvent systems. Biotechnology and bioengineering 20071001
Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies. Journal of clinical pharmacology 20071001
A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Experimental neurology 20071001
Are false-positive phencyclidine immunoassay instant-view multi-test results caused by overdose concentrations of Ibuprofen, metamizol, and dextromethorphan? Therapeutic drug monitoring 20071001
Effect of sampling procedures of release testing on drug release and scale-up production feasibility of multiple-unit dextromethorphan resinate tablets: a technical note. AAPS PharmSciTech 20071001
Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070901
Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action. The neurologist 20070901
Dextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical toxicology (Philadelphia, Pa.) 20070901
[Dangerous party drugs: A2 and cough medicines. Increasing interest among Swedish adolescents]. Lakartidningen 20070901
It's nothing to laugh about: understanding disorders of emotional expression. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20070901
The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan. European journal of pharmacology 20070827
Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect. Journal of the neurological sciences 20070815
Modulating drug release and matrix erosion of alginate matrix capsules by microenvironmental interaction with calcium ion. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070801
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug metabolism and disposition: the biological fate of chemicals 20070801
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction. Drug metabolism and disposition: the biological fate of chemicals 20070801
Effects of dextromethorphan on dopamine dependent behaviours in rats. Indian journal of experimental biology 20070801
Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701
Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations. European biophysics journal : EBJ 20070701
Timolol metabolism in human liver microsomes is mediated principally by CYP2D6. Drug metabolism and disposition: the biological fate of chemicals 20070701
In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies. Journal of mass spectrometry : JMS 20070701
Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. Neurotoxicology 20070701
Electron density analyses of opioids: a comparative study. The journal of physical chemistry. A 20070628
Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. European journal of pharmacology 20070614
Preoperative oral dextromethorphan vs. clonidine to prevent tourniquet-induced cardiovascular responses in orthopaedic patients under general anaesthesia. European journal of anaesthesiology 20070601
Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. Synapse (New York, N.Y.) 20070601
Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clinical pharmacology and therapeutics 20070601
Separation of cold medicine ingredients using a precise MEKC method at elevated pH. Electrophoresis 20070601
'Pharming': the abuse of prescription and over-the-counter drugs in teens. Current opinion in pediatrics 20070601
[Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method]. Yao xue xue bao = Acta pharmaceutica Sinica 20070601
Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6. The American journal of geriatric pharmacotherapy 20070601
N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief. Journal of medicinal chemistry 20070531
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. The Journal of physiology 20070515
NMDA receptor antagonists: tools in neuroscience with promise for treating CNS pathologies. The Journal of physiology 20070515
Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. Journal of pharmaceutical and biomedical analysis 20070509
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. Neurochemistry international 20070501
Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA). European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070501
Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. Anesthesia and analgesia 20070501
'Crystal dex:' free-base dextromethorphan. The Journal of emergency medicine 20070501
Dextromethorphan in Wisconsin drivers. Journal of analytical toxicology 20070501
FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children? Child health alert 20070501
Separation and determination of four active components in medicinal preparations by flow injection-capillary electrophoresis. Journal of pharmaceutical and biomedical analysis 20070411
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats. Psychopharmacology 20070401
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. European journal of clinical pharmacology 20070401
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clinical pharmacology and therapeutics 20070401
Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic & clinical pharmacology & toxicology 20070401
A phase III randomized, double-blind, placebo-controlled study evaluating dextromethorphan plus slow-release morphine for chronic cancer pain relief in terminally ill patients. Journal of pain and symptom management 20070401
Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153. Chemical & pharmaceutical bulletin 20070401
Involuntary emotional expression disorder: treating the untreated. CNS spectrums 20070401
Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. International journal of clinical pharmacology and therapeutics 20070401
Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study. Haematologica 20070401
Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Respiratory physiology & neurobiology 20070315
Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period. Psychopharmacology 20070301
Drug release properties of polymer coated ion-exchange resin complexes: experimental and theoretical evaluation. Journal of pharmaceutical sciences 20070301
Possible role of pseudoephedrine and other over-the-counter cold medications in the deaths of very young children. Journal of forensic sciences 20070301
Novel approach to performing metabolite identification in drug metabolism. Journal of chromatographic science 20070301
Treatment of the common cold. American family physician 20070215
Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis. Journal of medicinal chemistry 20070208
Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application. Journal of clinical pharmacology 20070201
Marketing and drug costs: who is laughing and crying? Annals of neurology 20070201
Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20070117
A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations. Journal of pharmaceutical and biomedical analysis 20070104
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. The journal of pain : official journal of the American Pain Society 20070101
A placebo double-blind pilot study of dextromethorphan for problematic behaviors in children with autism. Autism : the international journal of research and practice 20070101
Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population. Clinical pharmacology and therapeutics 20070101
Apomorphine-induced growth hormone response is attenuated by ethanol but not dextromethorphan. Alcoholism, clinical and experimental research 20070101
Reboxetine and cytochrome P450--comparison with paroxetine treatment in humans. International journal of clinical pharmacology and therapeutics 20070101
Dextromethorphan premedication reduces midazolam requirement: objective and subjective parameters in peribronchoscopy. Respiration; international review of thoracic diseases 20070101
Dextromethorphan: a review of N-methyl-d-aspartate receptor antagonist in the management of pain. CNS drug reviews 20070101
Challenges for Australia's Bio/Nanopharma Policies: trade deals, public goods and reference pricing in sustainable industrial renewal. Australia and New Zealand health policy 20070101
Efficacy of pre- and postoperative oral dextromethorphan for reduction of intra- and 24-hour postoperative morphine consumption for transabdominal hysterectomy. Pain medicine (Malden, Mass.) 20070101
Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. Arthritis research & therapy 20070101
Prior exposure to uninfected mosquitoes enhances mortality in naturally-transmitted West Nile virus infection. PloS one 20070101
Bench-to-bedside review: mechanisms and management of hyperthermia due to toxicity. Critical care (London, England) 20070101
CYP2D6 phenotyping with dextromethorphan. Pharmacological reports : PR 20070101
Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatric research 20061201
3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201
Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004. Archives of pediatrics & adolescent medicine 20061201
Dextromethorphan/quinidine: a novel dextromethorphan product for the treatment of emotional lability. Expert opinion on pharmacotherapy 20061201
The cost of over-the-counter substance abuse. Journal of child and adolescent psychopharmacology 20061201
The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy). Journal of psychopharmacology (Oxford, England) 20061101
Dextromethorphan premedication reduced postoperative analgesic consumption in patients after oral surgery. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20061101
The prevalence of dextromethorphan abuse among high school students. Pediatrics 20061101
Beneficial effects of LK-4, an analog of dextromethorphan on lipopolysaccharide-induced sepsis in rats. Journal of biomedical science 20061101
Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats. Pharmacology, biochemistry, and behavior 20061101
Effects of dextromethorphan on rats' acquisition of responding with delayed reinforcement. Pharmacology, biochemistry, and behavior 20061101
Modeling film-coat non-uniformity in polymer coated pellets: a stochastic approach. International journal of pharmaceutics 20061012
Vanished behind the counter. Starting this week, you'll need help buying your claritin and nyquil. U.S. news & world report 20061002
Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study. Clinical therapeutics 20061001
Standardization of method for the analysis of dextromethorphan in urine. Forensic science international 20060912
Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. Journal of biomedical science 20060901
Are any cold medications safe for a person on high blood pressure medication? Mayo Clinic women's healthsource 20060901
Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. Clinical pediatrics 20060901
Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. European journal of pharmacology 20060821
Dextromethorphan protects male but not female mice with brain ischemia. Neuroreport 20060821
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3. Biochemical and biophysical research communications 20060804
Expression, purification, and characterization of mouse CYP2d22. Drug metabolism and disposition: the biological fate of chemicals 20060701
Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. Drug metabolism and disposition: the biological fate of chemicals 20060701
Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons. Brain research 20060630
Dextromethorphan-induced neurologic illness in a patient with negative toxicology findings. Neurology 20060627
Pseudobulbar affect in multiple sclerosis: toward the development of innovative therapeutic strategies. Journal of the neurological sciences 20060615
The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients. The journal of pain : official journal of the American Pain Society 20060601
Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 20060601
Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy. Biochemical and biophysical research communications 20060512
Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Annals of neurology 20060501
CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico. Journal of clinical pharmacology 20060501
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail. Journal of clinical pharmacology 20060501
Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. European journal of pharmacology 20060424
CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug metabolism and disposition: the biological fate of chemicals 20060401
Efficacy, abuse, and toxicity of over-the-counter cough and cold medicines in the pediatric population. Current opinion in pediatrics 20060401
Preparation and in vitro release of dual-drug resinates containing equivalent content dextromethorphan and diphenhydramine. Drug development and industrial pharmacy 20060401
Simultaneous quantitation of five active principles in a pharmaceutical preparation: development and validation of a near infrared spectroscopic method. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060201
Repetitive dextromethorphan at adolescence affects water maze learning in female rats. The International journal of neuroscience 20060201
Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism. The Annals of pharmacotherapy 20060101
A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. General hospital psychiatry 20060101
Index of suspicion. Pediatrics in review 20060101
A qualitative systematic review of peri-operative dextromethorphan in post-operative pain. Acta anaesthesiologica Scandinavica 20060101
Cluster formation as a tool for development in Medicon Valley. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 20060101
Ovariectomy ameliorates dextromethorphan--induced memory impairment in young female rats. Journal of cellular and molecular medicine 20060101
Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: Beneficial effect of dextromethorphan. Hippocampus 20060101
Chronic addiction to dextromethorphan cough syrup: a case report. Journal of the American Board of Family Medicine : JABFM 20060101
Effect of dextromethorphan on reference memory assessed in rats by a three-panel runway task. Arzneimittel-Forschung 20060101
Effects of dextromethorphan on in vitro contractile responses of mouse and rat urinary bladders. Neurourology and urodynamics 20060101
Potential interactions of methylphenidate and atomoxetine with dextromethorphan. Journal of the American Pharmacists Association : JAPhA 20060101
Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers. Clinical pharmacokinetics 20060101
Additive effect of dextromethorphan on the inhibitory effect of anti-NT4 on morphine tolerance. Pharmacology 20060101
Preoperative cotreatment with dextromethorphan and ketorolac provides an enhancement of pain relief after laparoscopic-assisted vaginal hysterectomy. The Clinical journal of pain 20060101
CYP2D6 genotype and phenotype relationship in South Indians. Journal of postgraduate medicine 20060101
Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan. Lung 20060101
Comparative efficacy and tolerability of pholcodine and dextromethorphan in the management of patients with acute, non-productive cough : a randomized, double-blind, multicenter study. Treatments in respiratory medicine 20060101
OTC product: PediaCare Long-Acting Cough Freezer Pops. Journal of the American Pharmacists Association : JAPhA 20060101
OTC product: Zicam Cold and Flu Medicated Spoons. Journal of the American Pharmacists Association : JAPhA 20060101
OTC product: Theraflu Thin Strips. Journal of the American Pharmacists Association : JAPhA 20060101
Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver. Life sciences 20051205
Identification of CYP2D6 impaired functional alleles in Mexican Americans. European journal of clinical pharmacology 20051201
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail. Journal of clinical pharmacology 20051201
Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. European journal of clinical pharmacology 20051201
Dextromethorphan psychosis, dependence and physical withdrawal. Addiction biology 20051201
Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clinical pharmacology and therapeutics 20051201
A Cadillac ride to the emergency department. Pediatric emergency care 20051201
Dose-response relationship with increasing doses of dextromethorphan for children with cough. Clinical therapeutics 20051201
Recombinant production of human microsomal cytochrome P450 2D6 in the methylotrophic yeast Pichia pastoris. Chembiochem : a European journal of chemical biology 20051101
The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans. Journal of clinical pharmacology 20051101
CYP2D6 genotype and phenotype determination in a Mexican Mestizo population. European journal of clinical pharmacology 20051101
Cerebellar degeneration and folate deficiency due to cough mixture abuse. Haematologica 20051101
Dextromethorphan abuse in Thai adolescents: A report of two cases and review of literature. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101
Enhancing the uptake of dextromethorphan in the CNS of rats by concomitant administration of the P-gp inhibitor verapamil. Life sciences 20051021
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement. The Journal of pharmacology and experimental therapeutics 20051001
A study of the effects of lorazepam and dextromethorphan on the response to cortical 1 Hz repetitive transcranial magnetic stimulation. Neuroreport 20050908
Acute psychosis with Coricidin cold medicine. The Annals of pharmacotherapy 20050901
Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis. Journal of pharmaceutical and biomedical analysis 20050901
QT and QTc interval with standard and supratherapeutic doses of darifenacin, a muscarinic M3 selective receptor antagonist for the treatment of overactive bladder. Journal of clinical pharmacology 20050901
Side effects of dextromethorphan abuse, a case series. Addictive behaviors 20050901
Adolescent abuse of dextromethorphan. Clinical pediatrics 20050901
Relieving fibromyalgia pain. An epilepsy medication and a popular cough syrup both seem to work. Health news (Waltham, Mass.) 20050901
Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. Drug metabolism and disposition: the biological fate of chemicals 20050801
The treatment of the behavioral sequelae of autism with dextromethorphan: a case report. Journal of autism and developmental disorders 20050801
MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain research 20050719
Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance. Drug metabolism and disposition: the biological fate of chemicals 20050701
Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian journal of experimental biology 20050701
Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD. Journal of separation science 20050701
Inhibition of CYP2D6 activity by bupropion. Journal of clinical psychopharmacology 20050601
Coricidin HBP cough and cold addiction. Journal of the American Academy of Child and Adolescent Psychiatry 20050601
MorphiDex (morphine sulfate/dextromethorphan hydrobromide combination) in the treatment of chronic pain: three multicenter, randomized, double-blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance. Pain 20050601
Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. Biological & pharmaceutical bulletin 20050601
Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers. Drug metabolism and pharmacokinetics 20050601
[Symptomatic treatment of painful diabetic neuropathy]. Nihon rinsho. Japanese journal of clinical medicine 20050601
Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets. AAPS PharmSciTech 20050601
Treatment of pseudobulbar affect in ALS: October 26 highlight and commentary. Neurology 20050524
Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505
Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins 20050501
Preincisional dextromethorphan combined with thoracic epidural anesthesia and analgesia improves postoperative pain and bowel function in patients undergoing colonic surgery. Anesthesia and analgesia 20050501
Treatment of pseudobulbar affect in ALS. The Lancet. Neurology 20050501
Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biological & pharmaceutical bulletin 20050501
Effects of the N-methyl-D-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects. The journal of pain : official journal of the American Pain Society 20050501
The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific. Pharmacology, biochemistry, and behavior 20050501
Sol-gel-based solid-phase microextraction and gas chromatography-mass spectrometry determination of dextromethorphan and dextrorphan in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence? European journal of pharmacology 20050425
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. British journal of pharmacology 20050401
Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401
A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. Journal of pharmaceutical and biomedical analysis 20050401
NMDA antagonist modulation of morphine antinociception in female vs. male rats. Pharmacology, biochemistry, and behavior 20050401
Description and validation of a four-channel staggered LC-MS/MS system for high-throughput in vitro screens. Analytical chemistry 20050315
3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain. Synapse (New York, N.Y.) 20050301
Can Robitussin DM be used to treat cough during pregnancy? Medicine and health, Rhode Island 20050301
Dextromethorphan-induced delirium and possible methadone interaction. The American journal of geriatric pharmacotherapy 20050301
Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. The Journal of pharmacology and experimental therapeutics 20050201
Dextromethorphan differentially affects opioid antinociception in rats. British journal of pharmacology 20050201
Dextromethorphan metabolic phenotyping in an Iranian population. European journal of clinical pharmacology 20050201
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect. Pain 20050201
Treatment of emotional lability in ALS. The Lancet. Neurology 20050201
The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. Anesthesia and analgesia 20050201
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors. Analytical chemistry 20050201
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 20050201
Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. American journal of obstetrics and gynecology 20050201
Spreading depression expands traumatic injury in neocortical brain slices. Journal of neurotrauma 20050201
Protective effect of dextromethorphan against endotoxic shock in mice. Biochemical pharmacology 20050115
Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101
Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid communications in mass spectrometry : RCM 20050101
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. The pharmacogenomics journal 20050101
Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs in R&D 20050101
[Simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension by HPLC]. Se pu = Chinese journal of chromatography 20050101
High-throughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma. European journal of mass spectrometry (Chichester, England) 20050101
High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs. Journal of AOAC International 20050101
Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation. Journal of AOAC International 20050101
Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast cancer research : BCR 20050101
Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats. European journal of drug metabolism and pharmacokinetics 20050101
Therapeutic options for emotional lability: current and emerging treatments. The American journal of geriatric pharmacotherapy 20050101
Review of pseudobulbar affect including a novel and potential therapy. The Journal of neuropsychiatry and clinical neurosciences 20050101
Phenotypical expression of CYP2D6 in amerindians of tepehuano origin from Durango, Mexico. Proceedings of the Western Pharmacology Society 20050101
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. Folia medica Cracoviensia 20050101
Role of drug testing as an early warning programme: the experience of the Republic of Korea. Bulletin on narcotics 20050101
Codeine intoxication associated with ultrarapid CYP2D6 metabolism. The New England journal of medicine 20041230
LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals 20041201
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug metabolism and disposition: the biological fate of chemicals 20041201
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism. Biochemical pharmacology 20041201
Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH. Journal of clinical pharmacology 20041201
The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain. Anesthesia and analgesia 20041201
Dextromethorphan abuse. Pediatric emergency care 20041201
P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. Journal of psychopharmacology (Oxford, England) 20041201
Kids' cough drugs may not work. Consumer reports 20041201
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug metabolism and disposition: the biological fate of chemicals 20041101
Bladder emptying over a period of 10-45 years after a traumatic spinal cord injury. Spinal cord 20041101
Over-the-counter cough and cold medicines: should parents be using them for their children? The Annals of pharmacotherapy 20041101
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 20041101
Oral dextromethorphan reduces perioperative analgesic administration in children undergoing tympanomastoid surgery. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20041101
Dextromethorphan potentiates morphine antinociception at the spinal level in rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20041101
Commentary on: Severe manifestations of coricidin intoxication. The American journal of emergency medicine 20041101
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology 20041026
Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers. Journal of clinical pharmacology 20041001
Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs. Journal of veterinary pharmacology and therapeutics 20041001
[Clinical progress of neonatal non-ketotic hyperglycinemia under treatment]. Revista de neurologia 20041001
Do over-the-counter cough remedies work? Child health alert 20041001
[Club drugs: old medicines as new party drugs]. Medicina clinica 20040911
High-performance liquid chromatographic analysis of dextromethorphan, guaifenesin and benzoate in a cough syrup for stability testing. Journal of chromatography. A 20040910
Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine. Journal of pharmaceutical and biomedical analysis 20040903
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes. Journal of pharmaceutical and biomedical analysis 20040903
Isobolographic analysis for combinations of a full and partial agonist: curved isoboles. The Journal of pharmacology and experimental therapeutics 20040901
Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy. Acta anaesthesiologica Scandinavica 20040901
Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals 20040901
Dose-response relationship with increasing doses of dextromethorphan for children with cough. Clinical therapeutics 20040901
Club drugs: reasons for and consequences of use. Journal of psychoactive drugs 20040901
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems 20040901
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats. Life sciences 20040806
Adverse reaction to dextromethorphan. Allergy 20040801
Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking. Journal of medicinal chemistry 20040729
Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens. Forensic science international 20040716
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. Journal of clinical pharmacology 20040701
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 20040701
Trends in child and teen nonprescription drug abuse reported to a regional poison control center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040615
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite. The Biochemical journal 20040601
Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity. Clinica chimica acta; international journal of clinical chemistry 20040601
Validated assays for human cytochrome P450 activities. Drug metabolism and disposition: the biological fate of chemicals 20040601
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain 20040601
Dextromethorphan in pain control--an old drug with new clinical application. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040601
Oral slow release dextromethorphan premedication provides a pethidine spare effect on posthemorrhoidectomy pain management. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040601
[Determination of dextrorphan in human plasma and pharmacokinetic study]. Yao xue xue bao = Acta pharmaceutica Sinica 20040601
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behavioural brain research 20040505
Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure. European journal of pharmacology 20040503
Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. The Journal of pharmacology and experimental therapeutics 20040501
A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesthesia and analgesia 20040501
Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica; the fate of foreign compounds in biological systems 20040501
Simple chromatography method for simultaneous determination of dextromethorphan and its main metabolites in human plasma with fluorimetric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405
Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan. Bioorganic & medicinal chemistry letters 20040405
Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline. British journal of clinical pharmacology 20040401
Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. British journal of clinical pharmacology 20040401
Preoperative oral dextromethorphan attenuated tourniquet-induced arterial blood pressure and heart rate increases in knee cruciate ligament reconstruction patients under general anesthesia. Anesthesia and analgesia 20040401
The use of dextromethorphan to treat repetitive self-directed scratching, biting, or chewing in dogs with allergic dermatitis. Journal of veterinary pharmacology and therapeutics 20040401
Influence of concomitant quinidine administration on dextromethorphan disposition in rats. Journal of veterinary pharmacology and therapeutics 20040401
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6. Drug metabolism and disposition: the biological fate of chemicals 20040401
Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats. Psychopharmacology 20040301
Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301
Dextromethorphan-associated epidural patient-controlled analgesia provides better pain- and analgesics-sparing effects than dextromethorphan-associated intravenous patient-controlled analgesia after bone-malignancy resection: a randomized, placebo-controlled, double-blinded study. Anesthesia and analgesia 20040301
Analgesic effect of dextromethorphan in neuropathic pain. Acta anaesthesiologica Scandinavica 20040301
Morphine potentiates dextromethorphan-induced vasodilation in rat superior mesenteric artery. European journal of pharmacology 20040213
Drug abuse update: dextromethorphan. Emergency medical services 20040201
Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. Cellular and molecular neurobiology 20040201
Antitussive activity of sigma-1 receptor agonists in the guinea-pig. British journal of pharmacology 20040101
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clinical pharmacology and therapeutics 20040101
Poor outcome for neonatal-type nonketotic hyperglycinemia treated with high-dose sodium benzoate and dextromethorphan. Journal of child neurology 20040101
Synthesis and identification of two potential oxidation degradants of oxymetazoline. Rapid communications in mass spectrometry : RCM 20040101
Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but is not related to the descending serotoninergic or adrenergic pathways. Journal of biomedical science 20040101
Dextromethorphan prevents circulatory failure in rats with endotoxemia. Journal of biomedical science 20040101
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry 20031209
On-line turbulent-flow chromatography-high-performance liquid chromatography-mass spectrometry for fast sample preparation and quantitation. Journal of chromatography. A 20031205
Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. Journal of clinical psychopharmacology 20031201
Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers. Clinical pharmacology and therapeutics 20031201
Single-point plasma or urine dextromethorphan method for determining CYP3A activity. Biopharmaceutics & drug disposition 20031201
Influence of methacrylic acid and hydroxypropylmethyl cellulose on the tablet properties and in vitro release of dextromethorphan hydrobromide. Die Pharmazie 20031201
Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031125
Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. The Journal of physiology 20031115
Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens. Naunyn-Schmiedeberg's archives of pharmacology 20031101
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the 'Cooperstown 5+1 cocktail'. Clinical pharmacology and therapeutics 20031101
A high-throughput method for enzyme kinetic studies. Journal of biomolecular screening 20031001
Severe manifestations of coricidin intoxication. The American journal of emergency medicine 20031001
Fatal cold medication intoxication in an infant. Journal of analytical toxicology 20031001
Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 20030917
Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes. Drug metabolism and disposition: the biological fate of chemicals 20030901
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes. European journal of biochemistry 20030901
Sex-related differences in the enhancement of morphine antinociception by NMDA receptor antagonists in rats. Pharmacology, biochemistry, and behavior 20030901
Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicology in vitro : an international journal published in association with BIBRA 20030801
Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadruple time-of-flight mass spectrometry and in-silico prediction. Current drug metabolism 20030801
Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clinical pharmacology and therapeutics 20030801
Bromide intoxication by the combination of bromide-containing over-the-counter drug and dextromethorphan hydrobromide. Human & experimental toxicology 20030801
Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition. British journal of clinical pharmacology 20030701
Dextromethorphan induces multifocal fixed drug eruption. International journal of dermatology 20030601
Treatment of the common cold. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030601
Dextromethorphan prevents the diethyldithiocarbamate enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice. Brain research 20030530
Determination of dextromethorphan and its metabolites in rat serum by liquid-liquid extraction and liquid chromatography with fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525
The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat. Brain research. Developmental brain research 20030514
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex. Journal of neurophysiology 20030501
Dextromethorphan alters gene expression in rat brain hippocampus and cortex. International journal of molecular medicine 20030501
Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug metabolism and disposition: the biological fate of chemicals 20030501
Dextromethorphan and intrathecal morphine for analgesia after Caesarean section under spinal anaesthesia. British journal of anaesthesia 20030501
Preoperative and postoperative dextromethorphan provides sustained reduction in postoperative pain and patient-controlled epidural analgesia requirement: a randomized, placebo-controlled, double-blind study in lower-body bone malignancy-operated patients. Cancer 20030501
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice. Behavioural pharmacology 20030501
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. The Journal of pharmacology and experimental therapeutics 20030401
Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships. Clinical chemistry 20030401
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. The Biochemical journal 20030315
New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. Life sciences 20030307
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. Pain 20030301
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Xenobiotica; the fate of foreign compounds in biological systems 20030301
Safety of selegiline with cold medications. The Annals of pharmacotherapy 20030301
Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine. Pharmacology, biochemistry, and behavior 20030301
Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex. Brain research bulletin 20030215
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. The Journal of biological chemistry 20030207
Determination of dextromethorphan and its metabolite dextrorphan in human urine by capillary gas chromatography without derivatization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. Psychopharmacology 20030201
Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. Life sciences 20030103
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. Journal of medicinal chemistry 20030102
Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan. Pharmacology, biochemistry, and behavior 20030101
Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes. Acta pharmacologica Sinica 20030101
Morphine/dextromethorphan--Endo: E 3231, Morphidex. Drugs in R&D 20030101
Supraspinal N-methyl-D-aspartate receptor inhibition influences the micturition reflex and function of the upper urinary tract of anesthetized and conscious rats. Neurourology and urodynamics 20030101
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test. European journal of pain (London, England) 20030101
Total and corrected antioxidant capacity in hemodialyzed patients. BMC nephrology 20030101
Analysis of pharmacokinetic parameters for assessment of dextromethorphan metabolic phenotypes. Journal of biomedical science 20030101
Bridging sectors. Medicon Valley. Nature 20021212
Biotechnology in the Medicon Valley. Nature 20021212
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. Pharmacology, biochemistry, and behavior 20021201
Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug metabolism and disposition: the biological fate of chemicals 20021201
Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms. The Journal of pharmacology and experimental therapeutics 20021201
Consultation with the specialist: the central serotonin syndrome: paradigm for psychotherapeutic misadventure. Pediatrics in review 20021201
An informal discussion of emergency nurses' current clinical practice: what's new and what works. Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20021201
Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells. Drug metabolism and disposition: the biological fate of chemicals 20021101
Effect of the low-affinity, noncompetitive N-methyl-d-aspartate receptor antagonist dextromethorphan on visceral perception in healthy volunteers. Alimentary pharmacology & therapeutics 20021101
Venous malformations associated with central pain: report of a case. Anesthesia and analgesia 20021101
Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. Journal of clinical pharmacology 20021101
Spreading depression: imaging and blockade in the rat neocortical brain slice. Journal of neurophysiology 20021101
[Dextromethorphan poisoning]. Anales espanoles de pediatria 20021101
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells. Xenobiotica; the fate of foreign compounds in biological systems 20021101
Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine. European journal of pharmacology 20021025
Simultaneous determination of dextromethorphan, diphenhydramine and phenylephrine in expectorant and decongestant syrups by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis 20021015
N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia. The Journal of pharmacology and experimental therapeutics 20021001
Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain : a journal of neurology 20021001
Mechanisms influencing acquisition and recall of motor memories. Journal of neurophysiology 20021001
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. Journal of cardiac failure 20021001
Is cytochrome P450 CYP2D activity present in pig liver? Pharmacology & toxicology 20021001
Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation. The Journal of physiology 20020901
Dextromethorphan for the reduction of immediate and late postoperative pain and morphine consumption in orthopedic oncology patients: a randomized, placebo-controlled, double-blind study. Cancer 20020901
[Dextromethorphane intoxication under co-medication with cytochrome P450-inhibitor fluoxetin: prolonged and accentuated signs of intoxication]. Psychiatrische Praxis 20020901
Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias. Methods and findings in experimental and clinical pharmacology 20020901
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. European journal of pharmacology 20020823
A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. Journal of pharmaceutical and biomedical analysis 20020822
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. Journal of medicinal chemistry 20020815
Magnetic resonance spectroscopy study of glycine pathways in nonketotic hyperglycinemia. Pediatric research 20020801
Effects of methylprednisolone and dextromethorphan on lipid peroxidation in an experimental model of spinal cord injury. Neurosurgical review 20020801
CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6. Pharmacotherapy 20020801
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life sciences 20020726
A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients. Drug and alcohol dependence 20020701
Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clinical pharmacology and therapeutics 20020701
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan. Brain research 20020628
Reduced (+/-)-3,4-methylenedioxymethamphetamine ('Ecstasy') metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochemical pharmacology 20020615
Inhibition kinetics of monoclonal antibodies against cytochromes P450. Drug metabolism and disposition: the biological fate of chemicals 20020601
Dextromethorphan reduces immediate and late postoperative analgesic requirements and improves patients' subjective scorings after epidural lidocaine and general anesthesia. Anesthesia and analgesia 20020601
A possible trend suggesting increased abuse from Coricidin exposures reported to the Texas Poison Network: comparing 1998 to 1999. Veterinary and human toxicology 20020601
Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. British journal of clinical pharmacology 20020601
Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder. Anesthesiology 20020601
Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder. Anesthesiology 20020601
Semi-automated liquid--liquid back-extraction in a 96-well format to decrease sample preparation time for the determination of dextromethorphan and dextrorphan in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020525
Effect of low-affinity NMDA receptor antagonists on electrical activity in mouse cortical slices. European journal of pharmacology 20020517
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine. Drug metabolism and disposition: the biological fate of chemicals 20020501
Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. Anesthesiology 20020501
Biotechnology in the Medicon Valley. Nature biotechnology 20020501
The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. Journal of clinical pharmacology 20020501
The promise of N-methyl-D-aspartate receptor antagonists in fibromyalgia. Rheumatic diseases clinics of North America 20020501
Modulation of human corticomotor excitability by somatosensory input. The Journal of physiology 20020415
Analgesic effects of dextromethorphan and morphine in patients with chronic pain. Pain 20020401
Selective suppression of late laryngeal adductor responses by N-methyl-D-aspartate receptor blockade in the cat. Journal of neurophysiology 20020301
CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. Clinical pharmacology and therapeutics 20020301
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology 20020301
Is glutamate involved in transient lower esophageal sphincter relaxations? Digestive diseases and sciences 20020301
EN-3231. Endo Pharmaceuticals. Current opinion in investigational drugs (London, England : 2000) 20020301
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. The Journal of pharmacology and experimental therapeutics 20020201
Development of a rapid and sensitive high-performance liquid chromatographic method to determine CYP2D6 phenotype in human liver microsomes. Biomedical chromatography : BMC 20020201
Glutamate-induced excitotoxicity in retina: neuroprotection with receptor antagonist, dextromethorphan, but not with calcium channel blockers. Neurochemical research 20020201
Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man. Pharmacology & toxicology 20020201
Cytochrome p450 assays. Current protocols in pharmacology 20020201
Common drugs, used in combination, may pose risk. Report on medical guidelines & outcomes research 20020125
Dextromethorphan can produce false positive phencyclidine testing with HPLC. The American journal of emergency medicine 20020101
Effect of ketamine, dextromethorphan, and MK-801 on cochlear dysfunction induced by transient ischemia. The Annals of otology, rhinology, and laryngology 20020101
Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation. Journal of clinical pharmacology 20020101
The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clinical pharmacology and therapeutics 20020101
Prediction models in the design of neural network based ECG classifiers: a neural network and genetic programming approach. BMC medical informatics and decision making 20020101
Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatric hematology and oncology 20020101
Dextromethorphan for phantom pain attenuation in cancer amputees: a double-blind crossover trial involving three patients. The Clinical journal of pain 20020101
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. Acta anaesthesiologica Belgica 20020101
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein. Archives of biochemistry and biophysics 20011201
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical research in toxicology 20011201
CYP2D6 polymorphism in a Mexican American population. Clinical pharmacology and therapeutics 20011201
Different job demands of nightshifts in hospitals. Journal of human ergology 20011201
Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats. European journal of pharmacology 20011109
Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. Drug metabolism and disposition: the biological fate of chemicals 20011101
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug metabolism and disposition: the biological fate of chemicals 20011101
Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life sciences 20011005
Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. Chest 20011001
St. John's wort: effect on CYP2D6 activity using dextromethorphan-dextrorphan ratios. Journal of clinical psychopharmacology 20011001
Abuse of Coricidin HBP cough & cold tablets: episodes recorded by a poison center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011001
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. Clinical pharmacology and therapeutics 20011001
Dextromethorphan in pregnancy. Chest 20010901
Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats. Neuroscience letters 20010824
Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics 20010801
Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California. Pharmacogenetics 20010801
The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humans. Psychopharmacology 20010801
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain. The European journal of surgery = Acta chirurgica 20010801
Combined pre-incisional oral dextromethorphan and epidural lidocaine for postoperative pain reduction and morphine sparing: a randomised double-blind study on day-surgery patients. Anaesthesia 20010701
NMDA receptor-mediated modulation of ventilation in obese Zucker rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20010701
Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan. Journal of clinical pharmacology 20010701
Increasing bioanalytical throughput using pcSFC-MS/MS: 10 minutes per 96-well plate. Analytical chemistry 20010701
Improved postoperative pain control in pediatric adenotonsillectomy with dextromethorphan. The Laryngoscope 20010701
[Work time distribution in night shift: are clinics facing a adjustment boom?]. Pflege Zeitschrift 20010701
Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats. European journal of pharmacology 20010629
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. European journal of pharmacology 20010629
Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity. Life sciences 20010629
Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats. European journal of pharmacology 20010622
Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test. Therapeutic drug monitoring 20010601
Cold-syrup induced movement disorder. Pediatric emergency care 20010601
Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. Behavioural brain research 20010501
Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr. Journal of clinical pharmacology 20010501
Dextromethorphan is an effective cough suppressant. The Journal of emergency medicine 20010501
An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19. European journal of clinical pharmacology 20010501
Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6. The Biochemical journal 20010415
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. Journal of chromatography. B, Biomedical sciences and applications 20010415
Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug metabolism and disposition: the biological fate of chemicals 20010401
Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe. Journal of clinical pharmacology 20010401
Angle closure risk from proprietary medicines. Eye (London, England) 20010401
Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation. Drug metabolism and disposition: the biological fate of chemicals 20010301
The effect of the preemptive use of the NMDA receptor antagonist dextromethorphan on postoperative analgesic requirements. Anesthesia and analgesia 20010301
Large-dose oral dextromethorphan as an adjunct to patient-controlled analgesia with morphine after knee surgery. Anesthesia and analgesia 20010201
The safety of dextromethorphan in pregnancy : results of a controlled study. Chest 20010201
Dextromethorphan attenuation of postoperative pain and primary and secondary thermal hyperalgesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010201
Estimation of the percolation thresholds in dextromethorphan hydrobromide matrices. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201
Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. British journal of clinical pharmacology 20010201
Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers. British journal of clinical pharmacology 20010201
Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation. Journal of clinical pharmacology 20010101
Terbinafine-associated inhibition of dextromethorphan metabolism in Chinese subjects. British journal of clinical pharmacology 20010101
Epidemiologic analysis of prenatal exposure to cough medicines containing dextromethorphan: no evidence of human teratogenicity. Teratology 20010101
Separation of cold medicine ingredients by capillary electrophoresis. Electrophoresis 20010101
Dextromethorphan and ecstasy pills. JAMA 20010101
The effect of the NMDA receptor blocker, dextromethorphan, on cribbing in horses. Pharmacology, biochemistry, and behavior 20010101
Genetic polymorphism of CYP2D6 in Tamil population. European journal of clinical pharmacology 20010101
High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid communications in mass spectrometry : RCM 20010101
The placebo response to citric acid-induced cough: pharmacodynamics and gender differences. Pulmonary pharmacology & therapeutics 20010101
The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects. Toxicology in vitro : an international journal published in association with BIBRA 20010101
The role of glutamatergic transmission in the pathogenesis of levodopa-induced dyskinesias. Potential therapeutic approaches. Neurologia i neurochirurgia polska 20010101
Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. The Journal of pharmacology and experimental therapeutics 20000601
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. British journal of clinical pharmacology 20000401
The antitussive activity of delta-opioid receptor stimulation in guinea pigs. The Journal of pharmacology and experimental therapeutics 20000201
Mimicking gene defects to treat drug dependence. Annals of the New York Academy of Sciences 20000101
Acute abstinence syndrome following abrupt cessation of long-term use of tramadol (Ultram): a case study. European journal of pain (London, England) 20000101
[Acute cholestatic hepatitis induced by dextromethorphan]. Gastroenterologia y hepatologia 19991001
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice. European journal of pharmacology 19990714
Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. The Journal of pharmacology and experimental therapeutics 19990401
Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain research 19990313
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. General pharmacology 19990301
Dextromethorphan- and pseudoephedrine-induced agitated psychosis and ataxia: case report. The Journal of emergency medicine 19990101
Preoperative dextromethorphan reduces intraoperative but not postoperative morphine requirements after laparotomy. Anesthesia and analgesia 19981101
Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease. Neurology 19980701
[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan]. Schweizerische medizinische Wochenschrift 19980207
CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication. Pharmacogenetics 19971201
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism. Pharmacogenetics 19971201
Effects of dextromethorphan in clinical doses on capsaicin-induced ongoing pain and mechanical hypersensitivity. Journal of pain and symptom management 19971001
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat. Brain research 19970509
Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients. Psychiatry research 19970324
NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology. The Journal of pharmacology and experimental therapeutics 19970201
Acute dystonia following standard doses of a cold medicine containing phenylpropanolamine. Clinical pediatrics 19970101
Dextromethorphan-induced mania. Psychosomatics 19960101
Acute dystonia in a child associated with therapeutic ingestion of a dextromethorphan containing cough and cold syrup. Journal of toxicology. Clinical toxicology 19960101
Pharmacological profile of dextrorphan. Arzneimittel-Forschung 19951101
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. The Journal of pharmacology and experimental therapeutics 19950901
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. Archives of biochemistry and biophysics 19950601
Cognitive deterioration from long-term abuse of dextromethorphan: a case report. Journal of psychiatry & neuroscience : JPN 19941101
The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. The American journal of emergency medicine 19941101
Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta neurochirurgica. Supplementum 19940101
Comparative effects of felbamate and other compounds on N-methyl-D-aspartic acid-induced convulsions and lethality in mice. Pharmacological research 19940101
Visual hallucinations after combining fluoxetine and dextromethorphan. The American journal of psychiatry 19921001
Dextromethorphan and high-dose benzoate therapy for nonketotic hyperglycinemia in an infant. The Journal of pediatrics 19920701
The need for rational therapeutics in the use of cough and cold medicine in infants. Pediatrics 19920401
Differential effects of morphinan drugs on haloperidol-induced catalepsy in rats: a comparative study with an N-methyl-D-aspartate antagonist. Archives internationales de pharmacodynamie et de therapie 19910101
Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. Journal of pharmaceutical sciences 19901201
Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats. British journal of pharmacology 19901101
Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant. Hepatology (Baltimore, Md.) 19890801
Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science (New York, N.Y.) 19890616
Dextromethorphan does not protect against quinolinic acid neurotoxicity in rat striatum. Neuroscience letters 19881219
Paranoid psychoses after abuse of proprietary cold remedies. The British journal of psychiatry : the journal of mental science 19871001
Objective evaluation of dextromethorphan and glaucine as antitussive agents. British journal of clinical pharmacology 19840501
Effect of the centrally acting antitussives on ascites tumor cells. Japanese journal of pharmacology 19830401
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