Home Aminos 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione

3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione

CAS No.:
125-84-8
Catalog Number:
AG000MZ6
Molecular Formula:
C13H16N2O2
Molecular Weight:
232.2783
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
98%
In Stock USA
United States
$38
- +
25g
98%
In Stock USA
United States
$100
- +
100g
98%
In Stock USA
United States
$225
- +
Product Description
Catalog Number:
AG000MZ6
Chemical Name:
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
CAS Number:
125-84-8
Molecular Formula:
C13H16N2O2
Molecular Weight:
232.2783
MDL Number:
MFCD00010122
IUPAC Name:
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
InChI:
InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
InChI Key:
ROBVIMPUHSLWNV-UHFFFAOYSA-N
SMILES:
CCC1(CCC(=O)NC1=O)c1ccc(cc1)N
EC Number:
204-756-4
Properties
Complexity:
321  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
232.121g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
232.283g/mol
Monoisotopic Mass:
232.121g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
72.2A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1.2  
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Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors. Bioorganic & medicinal chemistry letters 20030505
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Update on the current use of hormonals as therapy in advanced breast cancer. Anti-cancer drugs 20030401
Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection. Journal of pharmaceutical and biomedical analysis 20030401
Randomized trial of tamoxifen versus tamoxifen plus aminoglutethimide as adjuvant treatment in postmenopausal breast cancer patients with hormone receptor-positive disease: Austrian breast and colorectal cancer study group trial 6. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315
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Exemestane: treatment of breast cancer with selective inactivation of aromatase. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021115
A phase II study of cisplatin and vinorelbine in patients with metastatic breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20021101
Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorganic & medicinal chemistry letters 20021021
The evolving role of aromatase inhibitors in breast cancer. International journal of clinical oncology 20021001
Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase. Bioorganic chemistry 20021001
Secondary hormonal therapies in the treatment of prostate cancer. Urology 20020901
Glucocorticoids enhance activation of the human type II 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase gene. The Journal of steroid biochemistry and molecular biology 20020901
Enantiomeric separations using poly(L-valine) and poly(L-leucine) surfactants. Investigation of steric factors near the chiral center. Journal of chromatography. A 20020809
Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts. Biology of reproduction 20020701
FSH and LH induce progesterone production and progesterone receptor synthesis in cumulus cells: a requirement for meiotic resumption in porcine oocytes. Molecular human reproduction 20020701
11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020701
Aromatase inhibitors in breast cancer: current and evolving roles. Cleveland Clinic journal of medicine 20020701
Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds. Biochemical and biophysical research communications 20020607
Erratum to 'CNS drugs in Cushing's disease: pathophysiological and therapeutic implications for mood disorders' [Prog. Neuro-Psycol. Biol. Psychiatry, 26, 763 (2002)]. Progress in neuro-psychopharmacology & biological psychiatry 20020601
LC determination of aminoglutethimide enantiomers as dansyl and fluorescamine derivatives in tablet formulations. Journal of pharmaceutical and biomedical analysis 20020515
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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. Bioorganic & medicinal chemistry letters 20020408
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Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog. The Journal of small animal practice 20020301
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Tamoxifen resistant and refractory breast cancer: the value of aromatase inhibitors. Drugs 20020101
Endocrine and clinical endpoints of exemestane as neoadjuvant therapy. Cancer control : journal of the Moffitt Cancer Center 20020101
Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. Journal of andrology 20020101
Ectopic ACTH-syndrome due to a thymic carcinoid tumor. Acta clinica Belgica 20020101
Estrogen as therapy for breast cancer. Breast cancer research : BCR 20020101
Identification of the aromatase inhibitor aminoglutethimide in urine by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM 20020101
Aromatase inhibitors in breast cancer: an update. Cancer control : journal of the Moffitt Cancer Center 20020101
Interactions of antioestrogens and aromatase inhibitors. Forum (Genoa, Italy) 20020101
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High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery 20011201
A summary of second-line randomized studies of aromatase inhibitors. The Journal of steroid biochemistry and molecular biology 20011201
Adjuvant trials of aromatase inhibitors: determining the future landscape of adjuvant endocrine therapy. The Journal of steroid biochemistry and molecular biology 20011201
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The role of tamoxifen and aromatase inhibitors/inactivators in postmenopausal patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
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Sequential tamoxifen and aminoglutethimide versus tamoxifen alone in the adjuvant treatment of postmenopausal breast cancer patients: results of an Italian cooperative study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011115
Aromatase inhibitors from Broussonetia papyrifera. Journal of natural products 20011001
Acute stress-induced facilitation of the hypothalamic-pituitary-adrenal axis: evidence for the roles of stressor duration and serotonin. Neuroendocrinology 20010901
Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis. Toxicology 20010828
New D-modified androstane derivatives as aromatase inhibitors. Steroids 20010801
Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. General and comparative endocrinology 20010801
Nonsteroidal and steroidal aromatase inhibitors in breast cancer. Oncology (Williston Park, N.Y.) 20010801
Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. Journal of the National Cancer Institute 20010718
Cytotoxic treatment of adrenocortical carcinoma. World journal of surgery 20010701
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Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone. The Journal of pharmacology and experimental therapeutics 20010601
Expression of messenger RNA for gonadotropin receptor in the granulosa layer during the ovulatory cycle of hens. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010601
Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20010601
Luteinization factor-stimulated steroidogenesis in porcine granulosa cells. General physiology and biophysics 20010601
Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent. Endocrine 20010601
Contribution of progesterone, follicle stimulating hormone and glucocorticoids in survival of serum-free cultured granulosa cell explants. The Journal of endocrinology 20010501
Enantioseparation of aminoglutethimide and thalidomide by high performance liquid chromatography or supercritical fluid chromatography on mono-2 and mono-6-O-pentenyl-beta-cyclodextrin-based chiral stationary phases. Biomedical chromatography : BMC 20010501
ACTH-receptor expression, regulation and role in adrenocortial tumor formation. European journal of endocrinology 20010301
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. Journal of medicinal chemistry 20010301
Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor. Biochemical and biophysical research communications 20010216
Periovulatory changes in catfish ovarian oestradiol-17beta, oestrogen-2-hydroxylase and catechol-O-methyltransferase during GnRH analogue-induced ovulation and in vitro induction of oocyte maturation by catecholoestrogens. The Journal of endocrinology 20010201
Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type. Anti-cancer drug design 20010201
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Antiandrogen withdrawal syndrome associated with prostate cancer therapies: incidence and clinical significance. Drug safety 20001101
PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum. Endocrinology 19970801
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Methotrexate induced brain necrosis and severe leukoencephalopathy due to disconnection of an Ommaya device. Journal of neuro-oncology 19930301
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