Losartan carboxylic acid
| Title | Journal |
|---|---|
| Effects of CYP2C9*1/*3 and *1/*13 on the pharmacokinetics of losartan and its active metabolite E-3174. | International journal of clinical pharmacology and therapeutics 20120901 |
| High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501 |
| Pharmacokinetics of losartan and its active carboxylic acid metabolite E-3174 in five ethnic populations of China. | Journal of clinical pharmacy and therapeutics 20120401 |
| New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers. | European journal of medicinal chemistry 20120401 |
| Pre-treatment with curcumin enhances plasma concentrations of losartan and its metabolite EXP3174 in rats. | Biological & pharmaceutical bulletin 20120101 |
| Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics. | Acta pharmacologica Sinica 20111001 |
| Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats. | Acta pharmacologica Sinica 20110701 |
| CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay. | Drug metabolism and disposition: the biological fate of chemicals 20110501 |
| Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors. | Pharmacology 20110101 |
| Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. | Bioorganic & medicinal chemistry 20101215 |
| The physicochemical properties, in vitro metabolism and pharmacokinetics of a novel ester prodrug of EXP3174. | Molecular pharmaceutics 20101206 |
| Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin. | The Journal of pharmacy and pharmacology 20100701 |
| Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20100601 |
| A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity. | Pharmacogenetics and genomics 20100601 |
| Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro. | The Journal of pharmacy and pharmacology 20100101 |
| Effects of the CYP2C9*13 allele on the pharmacokinetics of losartan in healthy male subjects. | Xenobiotica; the fate of foreign compounds in biological systems 20091001 |
| Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation. | Hypertension (Dallas, Tex. : 1979) 20091001 |
| Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension. | Hypertension (Dallas, Tex. : 1979) 20091001 |
| Rapid determination of losartan and losartan acid in human plasma by multiplexed LC-MS/MS. | Journal of separation science 20091001 |
| Effect of soy extract administration on losartan pharmacokinetics in healthy female volunteers. | The Annals of pharmacotherapy 20090601 |
| Effect of peptide and nonpeptide antagonists of angiotensin II receptors on noradrenaline release in hypothalamus of rats with angiotensin II-induced increase of water intake. | Pharmacological reports : PR 20090101 |
| Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release. | Neurochemical research 20070901 |
| Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. | Basic & clinical pharmacology & toxicology 20070601 |
| Simultaneous determination of losartan, EXP-3174 and hydrochlorothiazide in plasma via fully automated 96-well-format-based solid-phase extraction and liquid chromatography-negative electrospray tandem mass spectrometry. | Analytical and bioanalytical chemistry 20070101 |
| Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. | The Journal of pharmacy and pharmacology 20061101 |
| Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis. | Journal of medicinal chemistry 20060713 |
| New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties. | Journal of medicinal chemistry 20060420 |
| Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites. | Hypertension (Dallas, Tex. : 1979) 20060301 |
| The effect of AST-120 on the single-dose pharmacokinetics of losartan and losartan acid (E-3174) in healthy subjects. | Journal of clinical pharmacology 20060301 |
| Inhibitory effect of 5-fluorouracil on cytochrome P450 2C9 activity in cancer patients. | Basic & clinical pharmacology & toxicology 20060201 |
| A116C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. | The American journal of gastroenterology 20051101 |
| Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists. | Journal of medicinal chemistry 20050630 |
| Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade. | Journal of hypertension 20050401 |
| Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats. | Kidney & blood pressure research 20050101 |
| Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor. | Molecular endocrinology (Baltimore, Md.) 20041201 |
| Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. | Hypertension (Dallas, Tex. : 1979) 20040501 |
| 'Network leaning' as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists. | The Journal of biological chemistry 20040409 |
| Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study. | Kidney & blood pressure research 20040101 |
| Efforts to understand the molecular basis of hypertension through drug:membrane interactions. | Current topics in medicinal chemistry 20040101 |
| [Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension]. | Kardiologiia 20040101 |
| Nitric oxide-dependent antiplatelet action of AT1-receptor antagonists in a pulmonary thromboembolism in mice. | Journal of cardiovascular pharmacology 20031201 |
| Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects. | European journal of clinical pharmacology 20031101 |
| [Dosage equivalents of AT1-receptor antagonists available in Germany]. | Deutsche medizinische Wochenschrift (1946) 20031031 |
| Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20030915 |
| Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins. | Journal of cardiovascular pharmacology 20030701 |
| Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites. | Journal of medicinal chemistry 20030605 |
| Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals. | Pharmacotherapy 20030601 |
| Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors. | Biochemical pharmacology 20030415 |
| A two-state model of antagonist-AT1 receptor interaction: further support by binding studies at low temperature. | Biochemical pharmacology 20030415 |
| Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. | Journal of medicinal chemistry 20030227 |
| The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake. | Acta physiologica et pharmacologica Bulgarica 20030101 |
| Comparison of the antagonistic effects of different angiotensin II receptor blockers in human coronary arteries. | European journal of heart failure 20021201 |
| Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7). | Hypertension (Dallas, Tex. : 1979) 20021101 |
| Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release. | Hypertension (Dallas, Tex. : 1979) 20021001 |
| Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. | The Journal of pharmacology and experimental therapeutics 20020801 |
| Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. | Fundamental & clinical pharmacology 20020801 |
| Functional antagonism of different angiotensin II type I receptor blockers in human arteries. | Cardiovascular drugs and therapy 20020701 |
| Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. | Journal of clinical pharmacy and therapeutics 20020601 |
| Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179. | Circulation research 20020419 |
| Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype. | Clinical pharmacology and therapeutics 20020101 |
| Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. | Therapeutic drug monitoring 20010801 |
| Angiotensin receptor blocker losartan suppresses platelet activity by interfering with thromboxane signaling. | Cardiovascular drugs and therapy 20010701 |
| CoenzymeA glutathione disulfide is a potent modulator of angiotensin II-induced vasoconstriction. | American journal of hypertension 20010201 |
| Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure. | Hypertension research : official journal of the Japanese Society of Hypertension 20010101 |
| Studies on the antithrombotic action of AT1 receptor antagonists. | Medical science monitor : international medical journal of experimental and clinical research 20010101 |
| EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction. | Journal of the American College of Cardiology 19990901 |
| Comparative study of TA-606, a novel angiotensin II receptor antagonist, with losartan in terms of species difference and orthostatic hypotension. | Japanese journal of pharmacology 19990901 |
| Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors. | British journal of pharmacology 19990201 |
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. | Journal of medicinal chemistry 19960202 |
| Angiotensin II receptors and angiotensin II receptor antagonists. | Pharmacological reviews 19930601 |