Adenosine A2A receptor as a drug discovery target.

Journal of medicinal chemistry 20140508

Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells.

Journal of immunology (Baltimore, Md. : 1950) 20131215

Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.

Inflammation 20130201

Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.

American journal of physiology. Regulatory, integrative and comparative physiology 20130101

Constitutive activity of the A2A adenosine receptor and compartmentalised cyclic AMP signalling fine-tune noradrenaline release.

Purinergic signalling 20121201

Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats.

Neuropharmacology 20121101

Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats.

Clinical science (London, England : 1979) 20120901

A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.

Behavioural pharmacology 20120901

Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture.

Neuroscience letters 20120726

Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β.

The FEBS journal 20120601

Adenosine A2A receptor activation prevents wear particle-induced osteolysis.

Science translational medicine 20120523

Activation of the adenosine A2A receptor attenuates experimental autoimmune myasthenia gravis severity.

European journal of immunology 20120501

The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation.

Inflammation 20120401

Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120401

Differential effects of the adenosine A₂A agonist CGS-21680 and haloperidol on food-reinforced fixed ratio responding in the rat.

Psychopharmacology 20120301

Distinctive immunoregulatory effects of adenosine on T cells of older humans.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120301

Cholesterol 27-hydroxylase but not apolipoprotein apoE contributes to A2A adenosine receptor stimulated reverse cholesterol transport.

Inflammation 20120201

Effects of A₂A adenosine receptor blockade or stimulation on alcohol intake in alcohol-preferring rats.

Psychopharmacology 20120201

Endotoxin-induced effects on nucleotide catabolism in mouse kidney.

European journal of pharmacology 20120115

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Journal of medicinal chemistry 20120112

A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A(2A) receptors in ethanol-activated liver stellate cells.

Chemico-biological interactions 20120105

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis.

PloS one 20120101

Adenosine reduces cell surface expression of toll-like receptor 4 and inflammation in response to lipopolysaccharide and matrix products.

Journal of cardiovascular translational research 20111201

Activation of adenosine A2A receptor up-regulates BDNF expression in rat primary cortical neurons.

Neurochemical research 20111201

CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation.

European journal of pharmacology 20111001

CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis.

The Journal of rheumatology 20111001

Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.

Kidney international 20110801

Adenosine A(2A) agonists as therapy for glomerulonephritis.

Kidney international 20110801

Synaptically driven state transitions in distal dendrites of striatal spiny neurons.

Nature neuroscience 20110701

Adenosine 2A receptor is protective against renal injury in MRL/lpr mice.

Lupus 20110601

Regulation of epithelial sodium channel α-subunit expression by adenosine receptor A₂a in alveolar epithelial cells.

Chinese medical journal 20110501

Stimulation of A(₂a) adenosine receptor abolishes the inhibitory effect of arachidonic acid on the basolateral 50-pS K channel in the thick ascending limb.

American journal of physiology. Renal physiology 20110401

Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110401

On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.

Journal of molecular biology 20110311

Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase.

American journal of physiology. Renal physiology 20110201

Adenosine A(2A) receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes.

European journal of pharmacology 20110125

Novel 8-(furan-2-yl)-3-benzyl thiazolo [5,4-e][1,2,4] triazolo [1,5-c] pyrimidine-2(3H)-thione as selective adenosine A(2A) receptor antagonist.

Neuroscience letters 20110113

Excitatory effect of the A2A adenosine receptor agonist CGS-21680 on spontaneous and K+-evoked acetylcholine release at the mouse neuromuscular junction.

Neuroscience 20110113

Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.

Cancer immunology, immunotherapy : CII 20110101

Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects.

Journal of neuroinflammation 20110101

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.

Arthritis research & therapy 20110101

Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.

Microcirculation (New York, N.Y. : 1994) 20101101

Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

Neuroscience 20101027

Adenosine can mediate its actions through generation of reactive oxygen species.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20101001

Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.

American journal of physiology. Heart and circulatory physiology 20101001

Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.

Spinal cord 20100901

Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine.

American journal of physiology. Heart and circulatory physiology 20100901

Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.

Journal of immunology (Baltimore, Md. : 1950) 20100715

Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.

Journal of neuroscience research 20100701

An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets.

Experimental physiology 20100701

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

American journal of physiology. Regulatory, integrative and comparative physiology 20100701

Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonists.

Behavioural brain research 20100626

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100623

Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small-for-size liver transplantation.

Transplantation proceedings 20100601

Structure-based discovery of A2A adenosine receptor ligands.

Journal of medicinal chemistry 20100513

Adenosine receptor agonists affect taurine release from mouse brain stem slices in ischemia.

Amino acids 20100501

Adenosine A2A receptor-selective stimulation reduces signaling pathways involved in the development of intestine ischemia and reperfusion injury.

Shock (Augusta, Ga.) 20100501

Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.

Journal of neural transmission (Vienna, Austria : 1996) 20100501

Influence of CGS 21680, a selective adenosine A(2A) receptor agonist, on NMDA receptor function and expression in the brain of Huntington's disease mice.

Brain research 20100406

Role of adenosine A2 receptors in regulation of cerebral blood flow during induced hypotension.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100401

A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.

Journal of leukocyte biology 20100401

Adenosine up-regulates vascular endothelial growth factor in human macrophages.

Biochemical and biophysical research communications 20100212

Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.

American journal of physiology. Heart and circulatory physiology 20100201

Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.

Hearing research 20100201

Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.

Bioorganic & medicinal chemistry letters 20100201

The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.

Brain research 20100108

Selective adenosine A(2a) receptor agonists reduce the apoptosis in an experimental model of spinal cord trauma.

Journal of biological regulators and homeostatic agents 20100101

Effects of adenosine A(2A) and A(2B) receptor activation on signaling pathways and cytokine production in human uroepithelial cells.

Pharmacology 20100101

Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.

PloS one 20100101

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

Biochemical pharmacology 20091215

The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid body.

Brain research 20091208

The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord.

Shock (Augusta, Ga.) 20091201

Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201

Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice.

American journal of physiology. Heart and circulatory physiology 20091101

Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats.

Psychopharmacology 20091001

Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.

Journal of leukocyte biology 20090901

Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease.

The European journal of neuroscience 20090901

Platelet function analyzer (PFA-100) offers higher sensitivity and specificity than thromboelastography (TEG) in detection of platelet dysfunction.

Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20090901

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.

Human molecular genetics 20090815

Blocking adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801

SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.

Bioorganic & medicinal chemistry letters 20090801

1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.

Journal of medicinal chemistry 20090709

A2A adenosine receptor deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice.

The Journal of pharmacology and experimental therapeutics 20090701

Spinal NMDA receptor activation is necessary for de novo, but not the maintenance of, A2a receptor-mediated phrenic motor facilitation.

Journal of applied physiology (Bethesda, Md. : 1985) 20090701

The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.

British journal of pharmacology 20090701

Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.

Bioorganic & medicinal chemistry 20090701

Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats.

Critical care medicine 20090701

Adenosine A(2A) receptor mediates microglial process retraction.

Nature neuroscience 20090701

The role of adenosine in hypercarbic hyperemia: in vivo and in vitro studies in adenosine 2(A) receptor knockout and wild-type mice.

Journal of neurosurgery 20090501

Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.

Journal of cardiovascular pharmacology 20090501

Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.

Current drug safety 20090501

Regulation of hind-limb tone by adenosine A2A receptor in rats.

Neuroscience 20090410

Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity.

American journal of physiology. Heart and circulatory physiology 20090401

Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.

Autonomic neuroscience : basic & clinical 20090312

High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases.

American journal of physiology. Regulatory, integrative and comparative physiology 20090301

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors.

Journal of neurochemistry 20090301

Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus.

Neuropharmacology 20090201

Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells.

Experimental neurology 20090201

Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121

Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.

PloS one 20090101

An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells.

Journal of neurochemistry 20081201

Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes.

American journal of physiology. Heart and circulatory physiology 20081201

FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity.

Nature neuroscience 20081201

Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages.

Arthritis and rheumatism 20081201

Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurones.

Pflugers Archiv : European journal of physiology 20081101

Electron probe X-ray microanalysis of intact pathway for human aqueous humor outflow.

American journal of physiology. Cell physiology 20081101

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.

American journal of physiology. Heart and circulatory physiology 20081101

Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.

American journal of physiology. Heart and circulatory physiology 20081101

Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms.

Acta anaesthesiologica Scandinavica 20081101

Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20080903

Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats.

Psychopharmacology 20080901

Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils.

Molecular pharmacology 20080901

Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner.

Molecular pharmacology 20080901

Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia.

Placenta 20080901

Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep.

Brain research 20080821

N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors.

European journal of medicinal chemistry 20080801

Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer.

Bioorganic & medicinal chemistry letters 20080801

Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals.

Brain research 20080711

Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart.

Journal of cellular physiology 20080701

Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells.

Hepatology (Baltimore, Md.) 20080701

Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.

European journal of pharmacology 20080624

Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.

Anesthesia and analgesia 20080601

Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake.

Pharmacology, biochemistry, and behavior 20080501

Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep.

Journal of neurochemistry 20080501

Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine.

Neuropharmacology 20080501

Up-regulation of A 2B adenosine receptor in A 2A adenosine receptor knockout mouse coronary artery.

Journal of molecular and cellular cardiology 20080501

[Different effects of adenosine A2A receptors in the models of traumatic brain injury and peripheral tissue injury].

Sheng li xue bao : [Acta physiologica Sinica] 20080425

Synthesis of eudistomin D analogues and its effects on adenosine receptors.

Bioorganic & medicinal chemistry 20080401

Actions of adenosine A 2A receptors on synaptic connections of spiny projection neurons in the neostriatal inhibitory network.

Journal of neurophysiology 20080401

Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20080227

Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.

Bioorganic & medicinal chemistry letters 20080215

A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+ -evoked [3H]-GABA release from rat hippocampal nerve terminals.

Neuroscience letters 20080117

Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.

Veterinary immunology and immunopathology 20080115

Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.

Neuron 20080110

Fetal alcohol exposure alters cerebrovascular reactivity to vasoactive intestinal peptide in adult sheep.

Neonatology 20080101

Effect of adenosine A2 receptor stimulation on platelet activation-aggregation: differences between canine and human models.

Thrombosis research 20080101

Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats.

The Journal of pharmacology and experimental therapeutics 20080101

Regulation of A(2A) adenosine receptor expression and functioning following permanent focal ischemia in rat brain.

Journal of neurochemistry 20080101

Flow cytometry application for studies on adenosine A2A receptors expression.

Acta poloniae pharmaceutica 20080101

Paradoxical effects of adenosine receptor ligands on hydroxyl radical generation by L-DOPA in the rat striatum.

Pharmacological reports : PR 20080101

Effect of the pyridoindole SMe1EC2 and compounds affecting A(1) and A(2A) adenosine receptors in rat hippocampus under ischemia in vitro.

Pharmacological reports : PR 20080101

Involvement of adenosine receptor agonists on the development of hypersensitivity to acute dose of morphine during morphine withdrawal period.

Pharmacological reports : PR 20080101

The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors.

Behavioural brain research 20071211

Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes.

Journal of cellular physiology 20071201

Adenosine induces expression of glial cell line-derived neurotrophic factor (GDNF) in primary rat astrocytes.

Neuroscience research 20071201

Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.

American journal of physiology. Heart and circulatory physiology 20071201

Altering cAMP levels within a central pattern generator modifies or disrupts rhythmic motor output.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20071201

Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors.

The American journal of pathology 20071201

Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition.

The Journal of pharmacology and experimental therapeutics 20071101

Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.

Neuropharmacology 20071101

Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure.

Pediatric research 20071101

Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB.

Proceedings of the National Academy of Sciences of the United States of America 20071023

Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus.

Neuroscience 20071012

Activation of central adenosine A(2A) receptors enhances superior laryngeal nerve stimulation-induced apnea in piglets via a GABAergic pathway.

Journal of applied physiology (Bethesda, Md. : 1985) 20071001

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor.

Molecular and cellular neurosciences 20070901

Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.

American journal of veterinary research 20070901

The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.

Pharmacological research 20070801

Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.

American journal of physiology. Renal physiology 20070701

Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.

European journal of immunology 20070601

Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats.

Canadian journal of physiology and pharmacology 20070601

Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors.

Bioorganic & medicinal chemistry 20070501

The adenosine A2A receptor agonist CGS 21680 fails to ameliorate the course of dextran sulphate-induced colitis in mice.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070501

Opposite effects of the A2A receptor agonist CGS21680 in the striatum of Huntington's disease versus wild-type mice.

Neuroscience letters 20070424

The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats.

Brain research 20070420

Mitogen-activated protein kinase signaling is involved in suramin-induced neurite outgrowth in a neuronal cell line.

Biochemical and biophysical research communications 20070413

Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.

Naunyn-Schmiedeberg's archives of pharmacology 20070401

Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats.

Psychopharmacology 20070301

Attenuation of experimental subarachnoid hemorrhage--induced cerebral vasospasm by the adenosine A2A receptor agonist CGS 21680.

Journal of neurosurgery 20070301

Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.

American journal of physiology. Gastrointestinal and liver physiology 20070201

Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling.

Brain research 20070119

Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium.

Pflugers Archiv : European journal of physiology 20070101

Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock.

Shock (Augusta, Ga.) 20070101

Protective effect of adenosine A2A receptor activation in small-for-size liver transplantation.

Transplant international : official journal of the European Society for Organ Transplantation 20070101

Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.

American journal of physiology. Heart and circulatory physiology 20061201

Protective effects of adenosine A2A agonist during hemorrhagic shock: a simple intervention may result in a complex response.

Critical care medicine 20061201

The impact of adenosine and A(2B) receptors on glucose homoeostasis.

The Journal of pharmacy and pharmacology 20061201

Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level.

Archives of biochemistry and biophysics 20061101

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

Cardiovascular research 20061101

Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias.

Journal of the neurological sciences 20061025

Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner.

Brain research 20061003

Stimulation of adenosine receptors selectively activates gene expression in striatal enkephalinergic neurons.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061001

Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A(2B) receptor dysfunction.

The Journal of pharmacology and experimental therapeutics 20061001

Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs.

The Journal of physiology 20060901

A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.

Molecular and cellular neurosciences 20060901

Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors.

Neuroscience letters 20060814

Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.

Neuroscience 20060811

Activation of adenosine A2A receptors alters postsynaptic currents and depolarizes neurons of the supraoptic nucleus.

American journal of physiology. Regulatory, integrative and comparative physiology 20060801

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.

British journal of pharmacology 20060801

Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.

Kidney international 20060801

Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.

Kidney international 20060801

Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.

American journal of physiology. Renal physiology 20060701

Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.

Blood 20060701

Adenosine A2A receptor mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischaemia/reperfusion damage in rats.

The British journal of ophthalmology 20060701

Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.

Neuropharmacology 20060701

Reduction of apoptosis in the amygdala by an A2A adenosine receptor agonist following myocardial infarction.

Apoptosis : an international journal on programmed cell death 20060701

Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist.

Behavioural brain research 20060630

A novel cell-based assay for G-protein-coupled receptor-mediated cyclic adenosine monophosphate response element binding protein phosphorylation.

Journal of biomolecular screening 20060601

Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF.

Journal of leukocyte biology 20060501

The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: an in vivo preliminary study.

The Journal of surgical research 20060401

Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock.

Critical care medicine 20060401

Differential expression of adenosine receptors in human neutrophils: up-regulation by specific Th1 cytokines and lipopolysaccharide.

Journal of leukocyte biology 20060301

Adenosine receptor modelling. A1/A2a selectivity.

European journal of medicinal chemistry 20060301

Adenosine receptors as therapeutic targets.

Nature reviews. Drug discovery 20060301

Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep.

Journal of neurochemistry 20060301

A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis.

Inflammatory bowel diseases 20060201

Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats.

Journal of applied physiology (Bethesda, Md. : 1985) 20060101

Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.

American journal of physiology. Heart and circulatory physiology 20060101

Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.

Seizure 20060101

Involvement of peripheral adenosine A2 receptors in adenosine A1 receptor-mediated recovery of respiratory motor function after upper cervical spinal cord hemisection.

The journal of spinal cord medicine 20060101

The role of adenosine A2a receptors in experimental acute pancreatitis.

Advances in medical sciences 20060101

Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20051201

Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone.

Brain research 20051109

Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.

Journal of neurochemistry 20051101

Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects.

Journal of neurochemistry 20051101

Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.

European journal of pharmacology 20051031

A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.

The Journal of pharmacology and experimental therapeutics 20051001

Effect of adenosine A2A receptor agonist (CGS) on ischemia/reperfusion injury in isolated rat liver.

Apoptosis : an international journal on programmed cell death 20051001

Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose 'binge' cocaine-treated rats.

Synapse (New York, N.Y.) 20050901

Adenosine triggers preconditioning through MEK/ERK1/2 signalling pathway during hypoxia/reoxygenation in neonatal rat cardiomyocytes.

Journal of molecular and cellular cardiology 20050901

2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.

European journal of pharmacology 20050822

Adenosine inhibits the release of interleukin-1beta in activated human peripheral mononuclear cells.

Cytokine 20050821

Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids.

American journal of physiology. Renal physiology 20050801

Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo.

Blood 20050615

Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine.

Investigative ophthalmology & visual science 20050601

Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

Molecular pharmacology 20050501

Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat.

Neurobiology of learning and memory 20050501

Sustained cardioprotection afforded by A2A adenosine receptor stimulation after 72 hours of myocardial reperfusion.

Journal of cardiovascular pharmacology 20050501

CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

Journal of neurochemistry 20050401

The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes.

Biochemical pharmacology 20050315

Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.

British journal of pharmacology 20050301

An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.

Journal of neurochemistry 20050301

Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors.

Life sciences 20050211

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes.

Molecular pharmacology 20050201

Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.

Journal of neurochemistry 20050201

Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation.

Journal of cardiac failure 20050201

Functional expression of single-chain heterodimeric G-protein-coupled receptors for adenosine and dopamine.

Cell structure and function 20050201

In vitro platelet responsiveness to adenosine-mediated 'preconditioning' is age-dependent.

Journal of thrombosis and thrombolysis 20050201

Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.

The Journal of pharmacology and experimental therapeutics 20050101

Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors.

Neuroscience 20050101

A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis.

Arthritis research & therapy 20050101

Trafficking of adenosine A2A and dopamine D2 receptors.

Journal of molecular neuroscience : MN 20050101

Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.

Neurological research 20050101

Participation of adenosine system in the ketamine-induced motor activity in mice.

Pharmacological reports : PR 20050101

Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.

Epilepsia 20050101

Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells.

Journal of receptor and signal transduction research 20050101

Small conductance calcium-activated K+ channels, SkCa, but not voltage-gated K+ (Kv) channels, are implicated in the antinociception induced by CGS21680, a A2A adenosine receptor agonist.

Life sciences 20041210

Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells.

Journal of neurochemistry 20041201

Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.

The European journal of neuroscience 20041201

Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells.

Cell structure and function 20041201

2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.

Biochemical pharmacology 20041115

Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb.

American journal of physiology. Renal physiology 20041101

Effects of adenosine on optic nerve head circulation in rabbits.

Experimental eye research 20041101

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.

Journal of neurochemistry 20041101

Effect of omeprazole on gastric adenosine A1 and A2A receptor gene expression and function.

The Journal of pharmacology and experimental therapeutics 20041001

Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphatase.

Virology 20041001

Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus.

Naunyn-Schmiedeberg's archives of pharmacology 20041001

Hypoxanthine effects on cyclic AMP levels in human lymphocytes.

Nucleosides, nucleotides & nucleic acids 20041001

Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages.

Journal of leukocyte biology 20040901

Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.

Cardiovascular research 20040901

Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.

Journal of neurochemistry 20040901

Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease.

Brain research bulletin 20040830

Role of adenosine A1 receptor in the regulation of gastrin release.

The Journal of pharmacology and experimental therapeutics 20040801

The synergistic effect of adenosine A2A receptors agonist, type IV phosphodiestease inhibitor and ATP-sensitive K channels activation on free radicals production and aggregation of human polymorphoneuclear leukocytes.

Pharmacological research 20040801

Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion.

Journal of neurochemistry 20040801

Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.

Journal of medicinal chemistry 20040729

Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728

Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets.

Respiratory physiology & neurobiology 20040720

Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal.

Journal of neuroscience research 20040715

Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.

Journal of neuroscience research 20040701

Adenosine A2A receptor-induced inhibition of NMDA and GABAA receptor-mediated synaptic currents in a subpopulation of rat striatal neurons.

Neuropharmacology 20040601

Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis.

The American journal of pathology 20040601

An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade.

Molecular immunology 20040601

Role of adenosine A2A receptor in the regulation of gastric somatostatin release.

The Journal of pharmacology and experimental therapeutics 20040501

Protection against cisplatin ototoxicity by adenosine agonists.

Biochemical pharmacology 20040501

Direct interaction of adenosine with the TRPV1 channel protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040407

[Role of adenosine in intraocular pressure].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040401

Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040324

Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.

British journal of pharmacology 20040301

Post-ischemic cardioprotection by A2A adenosine receptors: dependent of phosphatidylinositol 3-kinase pathway.

Journal of cardiovascular pharmacology 20040301

Down-regulation of rat brain adenosine A1 receptors at the end of pregnancy.

Journal of neurochemistry 20040201

Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.

European journal of pharmacology 20040126

Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107

Stimulation of adenosine A2A receptors elicits zif/268 and NMDA epsilon2 subunit mRNA expression in cortex and striatum of the 'weaver' mutant mouse, a genetic model of nigrostriatal dopamine deficiency.

Neuroscience 20040101

Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists.

Archiv der Pharmazie 20040101

Effects of stable adenosine receptor agonists on bone marrow hematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil.

Physiological research 20040101

Barium, glibenclamide and CGS21680 prevent adenosine A1 receptor changes of ES coupling and spike threshold.

Neuro-Signals 20040101

Changes in intracellular cyclic AMP formation mask opposing modulation of kainate-enhanced glutamate release in the striatum.

Proceedings of the Western Pharmacology Society 20040101

Modulation of GABAergic transmission in the striatopallidal system by adenosine A2A receptors: a potential mechanism for the antiparkinsonian effects of A2A antagonists.

Neurology 20031209

Sleep regulation in adenosine A2A receptor-deficient mice.

Neurology 20031209

Adenosine modulation of [Ca2+]i in cerebellar granular cells: multiple adenosine receptors involved.

Brain research 20031205

Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats.

The Journal of pharmacology and experimental therapeutics 20031201

Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells.

Journal of immunology (Baltimore, Md. : 1950) 20031015

Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes.

Glia 20030801

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.

Journal of cellular biochemistry 20030801

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.

Journal of neurophysiology 20030801

Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.

Biochemical and biophysical research communications 20030718

Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats.

Psychopharmacology 20030701

Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701

The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701

Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos.

The European journal of neuroscience 20030701

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.

American journal of physiology. Lung cellular and molecular physiology 20030601

Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.

Cardiovascular research 20030601

Adenosine A2A receptor-mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor-mediated effects in the rat vas deferens.

Journal of neurochemistry 20030501

Binding of HTLV-1 virions to T cells occurs by a temperature and calcium-dependent process and is blocked by certain type 2 adenosine receptor antagonists.

Virus research 20030501

Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells.

The Journal of biological chemistry 20030425

Up-regulation of striatal adenosine A(2A) receptors in schizophrenia.

Neuroreport 20030303

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors.

Biochemical pharmacology 20030215

Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.

European journal of pharmacology 20030124

Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase.

Biochemical and biophysical research communications 20030117

Sole activation of three luminal adenosine receptor subtypes in different parts of coronary vasculature.

American journal of physiology. Heart and circulatory physiology 20030101

A role for histamine in cytokine modulation by the adenosine A(3) receptor agonist, 2-Cl-IB-MECA.

European journal of pharmacology 20021213

Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells.

American journal of physiology. Renal physiology 20021201

The adenosine A2A receptor agonist CGS 21680 exhibits antipsychotic-like activity in Cebus apella monkeys.

Behavioural pharmacology 20021201

Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice.

Brain research 20021129

The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells.

Journal of leukocyte biology 20021101

Actions of specific adenosine receptor A1 and A2 agonists and antagonists in recovery of phrenic motor output following upper cervical spinal cord injury in adult rats.

Clinical and experimental pharmacology & physiology 20021001

Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020915

Presynaptic adenosine A1 receptors regulate retinohypothalamic neurotransmission in the hamster suprachiasmatic nucleus.

Journal of neurobiology 20020905

Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.

Nature 20020815

Suppression of adenosine A(3) receptor-mediated hypotension and mast cell degranulation in the rat by dexamethasone.

The Journal of pharmacology and experimental therapeutics 20020801

Chronic caffeine treatment causes changes in cardiac adenosine receptor function in rats.

Pharmacology 20020701

Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart.

Cardiovascular research 20020701

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.

Molecular pharmacology 20020701

[Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage].

Zeitschrift fur Gastroenterologie 20020701

Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.

American journal of physiology. Heart and circulatory physiology 20020601

Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

British journal of pharmacology 20020601

Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

The American journal of pathology 20020601

Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.

The American journal of pathology 20020601

Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO.

The Journal of pharmacy and pharmacology 20020601

Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.

Neuroscience letters 20020517

Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium.

British journal of pharmacology 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord.

European journal of pharmacology 20020419

Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.

European journal of pharmacology 20020308

Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization.

American journal of physiology. Heart and circulatory physiology 20020301

Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP.

European journal of pharmacology 20020222

Cardiac effects of adenosine in A(2A) receptor knockout hearts: uncovering A(2B) receptors.

American journal of physiology. Heart and circulatory physiology 20020201

Effects of adenosine agonists on consumptive behaviour and body temperature.

The Journal of pharmacy and pharmacology 20020201

Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel).

Inflammation 20020201

2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.

Journal of medicinal chemistry 20020117

Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis.

Pancreas 20020101

Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart.

Cardiovascular research 20020101

Comparison of the vascular effects of adenosine in isolated mouse heart and aorta.

American journal of physiology. Heart and circulatory physiology 20020101

Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.

Neuroscience 20020101

Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells.

Journal of endotoxin research 20020101

Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.

Polish journal of pharmacology 20020101

Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.

Neuroreport 20011204

Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor.

Pain 20011201

Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.

European journal of pharmacology 20011116

Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.

American journal of physiology. Renal physiology 20011101

In vivo effects of adenosine A(2) receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo (13)C MR spectroscopy.

Journal of neurochemistry 20011101

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.

Journal of immunology (Baltimore, Md. : 1950) 20011001

Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.

British journal of pharmacology 20011001

Suppression of presynaptic responses to adenosine by activation of NMDA receptors.

European journal of pharmacology 20010907

Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.

British journal of pharmacology 20010901

Synergism between A(2A)-adenosine receptor activation and vasoactive intestinal peptide to facilitate [3H]-acetylcholine release from the rat motor nerve terminals.

Neuroscience letters 20010824

Adenosine A(1) receptors mediate plasma exudation from the oral mucosa.

Journal of applied physiology (Bethesda, Md. : 1985) 20010801

Functional characterization of coronary vascular adenosine receptors in the mouse.

British journal of pharmacology 20010801

Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum.

Neuroreport 20010703

Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.

The Journal of pharmacology and experimental therapeutics 20010701

Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.

Brain research bulletin 20010701

The adenosine A2A agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine.

Psychopharmacology 20010701

Adenosine A(1) receptor-mediated inhibition of protein kinase A-induced calcitonin gene-related peptide release from rat trigeminal neurons.

Molecular pharmacology 20010601

Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage.

Annals of neurology 20010601

Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.

American journal of physiology. Heart and circulatory physiology 20010501

Role of adenosine receptors in neuroprotective effect during global cerebral ischemia.

Bulletin of experimental biology and medicine 20010501

Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells.

The Journal of biological chemistry 20010427

Beneficial effects of adenosine A(2a) agonist CGS-21680 in infarcted and stunned porcine myocardium.

American journal of physiology. Heart and circulatory physiology 20010401

Examination of the involvement of protein kinase A in D2 dopamine receptor antagonist-induced immediate early gene expression.

Journal of neurochemistry 20010401

Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation.

Shock (Augusta, Ga.) 20010401

Blunted adenosine A2a receptor function in platelets in patients with major depression.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010401

Subchronic treatment with methamphetamine and phencyclidine differentially alters the adenosine A1 and A2A receptors in the prefrontal cortex, hippocampus, and striatum of the rat.

Neurochemical research 20010401

Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration.

Pharmacology, biochemistry, and behavior 20010401

A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.

Circulation research 20010316

Stimulation of p38 MAP kinase reduces acidosis and Na(+) overload in preconditioned hepatocytes.

FEBS letters 20010302

Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.

Cardiovascular research 20010301

Galpha(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum.

Journal of neurochemistry 20010301

The influence of tumour necrosis factor-alpha on the cardiovascular system of anaesthetized rats.

Naunyn-Schmiedeberg's archives of pharmacology 20010301

Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.

Journal of medicinal chemistry 20010215

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.

Proceedings of the National Academy of Sciences of the United States of America 20010213

Adenosine enhances glial glutamate efflux via A2a adenosine receptors.

Life sciences 20010209

Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.

Journal of molecular and cellular cardiology 20010201

Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep.

American journal of physiology. Heart and circulatory physiology 20010101

Adenosine attenuates reperfusion-induced apoptotic cell death by modulating expression of Bcl-2 and Bax proteins.

Journal of molecular and cellular cardiology 20010101

An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons.

Neuroscience 20010101

Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A(2A) receptors.

Journal of autonomic pharmacology 20010101

Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine.

Molecular pharmacology 20001201

[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Molecular pharmacology 20000501

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.

Journal of medicinal chemistry 20000127

Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.

Psychopharmacology 19991101

Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

Molecular pharmacology 19991001

Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.

Biochemical pharmacology 19990101

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Naunyn-Schmiedeberg's archives of pharmacology 19980101

Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists.

Journal of cardiovascular pharmacology 19970901

Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats.

Kidney international 19970801

Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats.

European journal of pharmacology 19970611

Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261.

British journal of pharmacology 19970501

Neonatal capsaicin attenuates mechanical nociception in the rat.

Neuroscience letters 19960223

Selective adenosine A2A receptor/dopamine D2 receptor interactions in animal models of schizophrenia.

European journal of pharmacology 19960111

Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.

The Journal of biological chemistry 19950609

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.

Journal of medicinal chemistry 19941014

KF17837: a novel selective adenosine A2A receptor antagonist with anticataleptic activity.

European journal of pharmacology 19940502

Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.

Journal of medicinal chemistry 19930514

Binding of the adenosine A2 receptor ligand [3H]CGS 21680 to human and rat brain: evidence for multiple affinity sites.

Journal of neurochemistry 19901101

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

The Journal of pharmacology and experimental therapeutics 19891201