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Prulifloxacin

CAS No.:
123447-62-1
Catalog Number:
AG000KL9
Molecular Formula:
C21H20FN3O6S
Molecular Weight:
461.4634
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%(HPLC)
In Stock USA
United States
$46
- +
25mg
98%(HPLC)
In Stock USA
United States
$72
- +
100mg
98%(HPLC)
In Stock USA
United States
$123
- +
1g
98%(HPLC)
In Stock USA
United States
$222
- +
5g
98%(HPLC)
In Stock USA
United States
$726
- +
Product Description
Catalog Number:
AG000KL9
Chemical Name:
Prulifloxacin
CAS Number:
123447-62-1
Molecular Formula:
C21H20FN3O6S
Molecular Weight:
461.4634
MDL Number:
MFCD00864847
IUPAC Name:
6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
InChI:
InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)
InChI Key:
PWNMXPDKBYZCOO-UHFFFAOYSA-N
SMILES:
O=c1oc(c(o1)CN1CCN(CC1)c1cc2c(cc1F)c(=O)c(c1n2C(C)S1)C(=O)O)C
Properties
Complexity:
931  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
461.106g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
461.464g/mol
Monoisotopic Mass:
461.106g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
125A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1  
Literature
Title Journal
Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology 20170615
Penetration of prulifloxacin into sinus mucosa of patients undergoing paranasal sinus elective endoscopic surgery. Journal of chemotherapy (Florence, Italy) 20120201
Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. Journal of andrology 20120101
Prulifloxacin versus levofloxacin in the treatment of respiratory and urinary tract infections: a multicentre, double-blind, randomized controlled clinical trial. Chemotherapy 20120101
Development and validation of a liquid chromatography-tandem mass spectrometry method to determine ulifloxacin, the active metabolite of prulifloxacin in rat and rabbit plasma: application to toxicokinetic study. Biomedical chromatography : BMC 20110801
Effects of levofloxacin, moxifloxacin and prulifloxacin on murine gut colonization by Candida albicans. Medical mycology 20110501
Prulifloxacin: a review focusing on its use beyond respiratory and urinary tract infections. International journal of antimicrobial agents 20110401
(99m)Tc-prulifloxacin in artificially infected animals. Radiosynthesis and biological evaluation. Nuklearmedizin. Nuclear medicine 20110101
[Susceptibility surveillance of clinical isolates to fluoroquinolone antimicrobial agents from 2003 to 2008: post-marketing study of prulifloxacin]. The Japanese journal of antibiotics 20100601
Effects of prulifloxacin on cardiac repolarization in healthy subjects: a randomized, crossover, double-blind versus placebo, moxifloxacin-controlled study. Clinical drug investigation 20100101
In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations. BMC microbiology 20100101
Prulifloxacin ECG study. Clinical drug investigation 20100101
Re: Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomised study. International journal of antimicrobial agents 20090901
Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomised study. International journal of antimicrobial agents 20090601
Prulifloxacin as a trigger of myasthenia gravis. Journal of the neurological sciences 20090515
Prulifloxacin: clinical studies of a broad-spectrum quinolone agent. Future microbiology 20090201
Penetration of orally administered prulifloxacin into human prostate tissue. Clinical drug investigation 20090101
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. Drug metabolism and pharmacokinetics 20090101
Effects of grepafloxacin on the function of human polymorphonuclear leukocytes and the phosphorylation of p38 mitogen-activated protein kinase. Chemotherapy 20090101
Determination of ulifloxacin, the active metabolite of prulifloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901
Capillary electrophoresis-chemiluminescence determination of norfloxacin and prulifloxacin. Analytica chimica acta 20080815
Simultaneous determination of Ciprofloxacin and the active metabolite of Prulifloxacin in aqueous human humor by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis 20080715
Determination of adenosine disodium triphosphate using prulifloxacin-terbium(III) as a fluorescence probe by spectrofluorimetry. Analytica chimica acta 20080310
Highly sensitive spectrofluorimetric determination of trace amounts of prulifloxacin using the aluminium(III)-prulifloxacin system. Luminescence : the journal of biological and chemical luminescence 20080101
Transporter-mediated hepatic uptake of ulifloxacin, an active metabolite of a prodrug-type new quinolone antibiotic prulifloxacin, in rats. Drug metabolism and pharmacokinetics 20071001
Treatment of Pseudomonas aeruginosa biofilms with a combination of fluoroquinolones and fosfomycin in a rat urinary tract infection model. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20071001
Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study. European journal of medicinal chemistry 20070701
In vitro activity of prulifloxacin against Escherichia coli isolated from urinary tract infections and the biological cost of prulifloxacin resistance. International journal of antimicrobial agents 20070601
Prulifloxacin versus levofloxacin in the treatment of chronic bacterial prostatitis: a prospective, randomized, double-blind trial. Journal of chemotherapy (Florence, Italy) 20070601
Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis. International journal of chronic obstructive pulmonary disease 20070301
Penetration of prulifloxacin into gynaecological tissues after single and repeated oral administrations. Drugs in R&D 20070101
Determination of the active metabolite of prulifloxacin in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307
[In vitro activity of prulifloxacin, levofloxacin and ciprofloxacin against urinary pathogens]. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20060301
Prulifloxacin: a new antibacterial fluoroquinolone. Expert review of anti-infective therapy 20060201
Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis. Pulmonary pharmacology & therapeutics 20060101
Pharmacologic characteristics of prulifloxacin. Pulmonary pharmacology & therapeutics 20060101
Microbiological rationale for the utilisation of prulifloxacin, a new fluoroquinolone, in the eradication of serious infections caused by Pseudomonas aeruginosa. International journal of antimicrobial agents 20051101
Interpretive criteria for disk diffusion susceptibility testing of ulifloxacin, the active metabolite of prulifloxacin. Journal of chemotherapy (Florence, Italy) 20050401
Prulifloxacin versus ciprofloxacin in the treatment of adults with complicated urinary tract infections. Urologia internationalis 20050101
Penetration of orally administered prulifloxacin into human lung tissue. Clinical pharmacokinetics 20050101
Prulifloxacin. Drugs 20040101
Prulifloxacin: in vitro (HERG current) and in vivo (conscious dog) assessment of cardiac risk. European journal of pharmacology 20030905
Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin. Drug metabolism and pharmacokinetics 20030101
[In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone]. The Japanese journal of antibiotics 20021201
[In vitro short-term bactericidal activity and accumulation of NM394, the active metabolite of prulifloxacin, for Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa: comparison with ciprofloxacin, levofloxacin, and gatifloxacin]. The Japanese journal of antibiotics 20021201
[Inhibitory activity of NM394, the active form of prodrug prulifloxacin against type II topoisomerase from Pseudomonas aeruginosa]. The Japanese journal of antibiotics 20021201
Randomized, double-blind study of prulifloxacin versus ciprofloxacin in patients with acute exacerbations of chronic bronchitis. Respiration; international review of thoracic diseases 20020101
Therapeutic effect of the quinolone prodrug prulifloxacin against experimental urinary tract infections in mice. Arzneimittel-Forschung 19961201
Properties