Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells.

BMC pharmacology & toxicology 20130101

Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.

Pediatric blood & cancer 20121215

Phase I dose-escalation trial of clofarabine followed by escalating doses of fractionated cyclophosphamide in children with relapsed or refractory acute leukemias.

Pediatric blood & cancer 20121215

Synergism between clofarabine and decitabine through p53R2: a pharmacodynamic drug-drug interaction modeling.

Leukemia research 20121101

Nucleoside analogue electrochemical behaviour and in situ evaluation of DNA-clofarabine interaction.

Bioelectrochemistry (Amsterdam, Netherlands) 20121001

Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients.

Cancer 20120915

Clofarabine, cyclophosphamide and etoposide for the treatment of relapsed or resistant acute leukemia in pediatric patients.

Leukemia & lymphoma 20120901

Clofarabine in pediatric acute leukemia: current findings and issues.

Pediatric blood & cancer 20120901

Clofarabine-containing conditioning regimen for allo-SCT in AML/ALL patients: a survey from the Acute Leukemia Working Party of EBMT.

European journal of haematology 20120901

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Structure (London, England : 1993) 20120808

Clofarabine and CY do not yield reliable engraftment of hematopoietic stem cells.

Bone marrow transplantation 20120801

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers.

Chemistry & biology 20120727

Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120710

A phase I dose-escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in patients with refractory or relapsed acute myeloid leukemia.

Leukemia & lymphoma 20120701

Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells.

Biochemical pharmacology 20120701

Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

Leukemia research 20120701

Phase 1 dose-escalation trial of clofarabine followed by escalating dose of fractionated cyclophosphamide in adults with relapsed or refractory acute leukaemias.

British journal of haematology 20120701

Drug shortages delay cancer clinical trials.

Journal of the National Cancer Institute 20120620

Long-term stability study of clofarabine injection concentrate and diluted clofarabine infusion solutions.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601

Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120601

Clofarabine-based chemotherapy for relapsed/refractory adult acute lymphoblastic leukemia and lymphoblastic lymphoma. The Spanish experience.

American journal of hematology 20120601

[Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells].

Zhongguo shi yan xue ye xue za zhi 20120601

Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors.

Naunyn-Schmiedeberg's archives of pharmacology 20120501

ABC transporters and their role in nucleoside and nucleotide drug resistance.

Biochemical pharmacology 20120415

Acute leukemia in adults: novel allogeneic transplant strategies.

Hematology (Amsterdam, Netherlands) 20120401

A phase I study in adults of clofarabine combined with high-dose melphalan as reduced-intensity conditioning for allogeneic transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120301

Outpatient consolidation treatment with clofarabine in a phase 2 study of older adult patients with previously untreated acute myelogenous leukemia.

Leukemia & lymphoma 20120301

Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines.

Molecular medicine reports 20120301

A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome.

Cancer 20120201

DNA building blocks: keeping control of manufacture.

Critical reviews in biochemistry and molecular biology 20120201

Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120201

Treatment of acute lymphoblastic leukemia in adults.

Critical reviews in oncology/hematology 20120101

Institutional experience with clofarabine and cytarabine in relapsed pediatric acute myeloid leukemia.

Journal of pediatric hematology/oncology 20120101

Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies.

British journal of haematology 20120101

Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome.

European journal of haematology 20120101

Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107).

British journal of haematology 20120101

Clofarabine in the treatment of newly diagnosed acute myeloid leukemia in older adults.

The Annals of pharmacotherapy 20120101

Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.

Clinical Medicine Insights. Oncology 20120101

Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment.

TheScientificWorldJournal 20120101

Novel therapies for aggressive B-cell lymphoma.

Advances in hematology 20120101

Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias.

Current pharmaceutical design 20120101

Immunotherapy targets in pediatric cancer.

Frontiers in oncology 20120101

Acute myeloid leukemia: focus on novel therapeutic strategies.

Clinical Medicine Insights. Oncology 20120101

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

PloS one 20120101

Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models.

Nucleosides, nucleotides & nucleic acids 20120101

Preclinical combination therapy of clofarabine plus radiation.

Nucleosides, nucleotides & nucleic acids 20120101

Treatment of elderly acute myeloid leukemia patients.

Current treatment options in oncology 20111201

Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia.

Blood 20111201

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

PLoS computational biology 20111201

Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia.

Annals of hematology 20111101

Isolation and characterization of a murine P388 leukemia line resistant to clofarabine.

Nucleosides, nucleotides & nucleic acids 20111101

Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies.

Blood 20111013

Clofarabine as a potential stimulant of alloreactivity.

Bone marrow transplantation 20111001

Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia.

British journal of haematology 20111001

Failure of hypomethylating agent-based therapy in myelodysplastic syndromes.

Seminars in oncology 20111001

Infections in relapsed or refractory acute myeloid leukemia patients given clofarabine+cytarabine.

Leukemia research 20110901

Applicability of a 'Pick a Winner' trial design to acute myeloid leukemia.

Blood 20110901

Determination of clofarabine triphosphate concentrations in leukemia cells using sensitive, isocratic high-performance liquid chromatography.

Anticancer research 20110901

Clofarabine-associated acute kidney injury and proteinuria.

Pharmacotherapy 20110901

Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820

Acute myeloid leukaemia: optimal management and recent developments.

Drugs 20110820

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.

Journal of medicinal chemistry 20110811

Early UK experience in the use of clofarabine in the treatment of relapsed and refractory paediatric acute lymphoblastic leukaemia.

British journal of haematology 20110801

[Novel conventional therapies in onco-hemathology].

Bulletin du cancer 20110801

Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital.

Clinics (Sao Paulo, Brazil) 20110801

A phase I trial of high-dose clofarabine, etoposide, and cyclophosphamide and autologous peripheral blood stem cell transplantation in patients with primary refractory and relapsed and refractory non-Hodgkin lymphoma.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110701

Clofarabine for myelodysplastic syndromes.

Expert opinion on investigational drugs 20110701

Busulfan and metronidazole: an often forgotten but significant drug interaction.

The Annals of pharmacotherapy 20110701

Acute lymphoblastic leukemia in adults.

Pediatric reports 20110622

Clofarabine ± fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110601

Pharmacokinetics of clofarabine in patients with high-risk inherited metabolic disorders undergoing brain-sparing hematopoietic cell transplantation.

Journal of clinical pharmacology 20110501

Educational paper. The development of new therapies for pediatric oncology.

European journal of pediatrics 20110501

Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer.

Cancer chemotherapy and pharmacology 20110401

Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway.

European journal of nuclear medicine and molecular imaging 20110401

Phase I trial and pharmacokinetic study of high-dose clofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia.

Leukemia 20110401

Efficacy and safety of clofarabine in relapsed and/or refractory non-Hodgkin lymphoma, including rituximab-refractory patients.

Cancer 20110401

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.

Cancer research 20110301

New nucleoside analogs for patients with hematological malignancies.

Expert opinion on investigational drugs 20110301

Successful management with clofarabine for refractory leukaemia in a young adult with chronic renal failure.

American journal of hematology 20110301

Novel agents for the treatment of acute myeloid leukemia in the older patient.

Journal of the National Comprehensive Cancer Network : JNCCN 20110301

New drug therapies in peripheral T-cell lymphoma.

Expert review of anticancer therapy 20110301

A network meta-analysis of randomized controlled trials of induction treatments in acute myeloid leukemia in the elderly.

Clinical therapeutics 20110301

Report of a phase II study of clofarabine and cytarabine in de novo and relapsed and refractory AML patients and in selected elderly patients at high risk for anthracycline toxicity.

The oncologist 20110201

Nursing considerations for optimal outpatient management of adult patients with leukemia treated with clofarabine.

Clinical journal of oncology nursing 20110201

Treatment of unfit patients with acute myeloid leukemia: a still open clinical challenge.

Clinical lymphoma, myeloma & leukemia 20110201

The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.

Biochemical pharmacology 20110115

Clofarabine for treatment of acute lymphoblastic leukaemia in adults.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.

Current medicinal chemistry 20110101

Interpreting clinical assays for histone deacetylase inhibitors.

Cancer management and research 20110101

Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity.

Acta poloniae pharmaceutica 20110101

A rapidly progressing Pancoast syndrome due to pulmonary mucormycosis: a case report.

Journal of medical case reports 20110101

Fermented wheat germ extract--nutritional supplement or anticancer drug?

Nutrition journal 20110101

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.

OncoTargets and therapy 20110101

Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

Marine drugs 20110101

An update on the management of peripheral T-cell lymphoma and emerging treatment options.

Journal of blood medicine 20110101

Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.

Cell cycle (Georgetown, Tex.) 20101215

Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML.

Bone marrow transplantation 20101201

A phase II study of low dose intravenous clofarabine for elderly patients with myelodysplastic syndrome who have failed 5-azacytidine.

Leukemia & lymphoma 20101201

Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia.

British journal of haematology 20101201

Influence of clofarabine on transcriptional activity of PTEN, APC, RARB2, ZAP70 genes in K562 cells.

Anticancer research 20101101

Rare tumors research in emerging countries.

Rare tumors 20100930

Clofarabine in the treatment of poor risk acute myeloid leukaemia.

Hematological oncology 20100901

Ulcerated plaque under a ruby ring in an immunosuppressed patient.

Dermatology online journal 20100815

Current and future management options for myelodysplastic syndromes.

Drugs 20100730

Effect of hemodialysis on the plasma levels of clofarabine.

Pediatric blood & cancer 20100715

Novel PET probes specific for deoxycytidine kinase.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100701

Interstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies.

Environmental and molecular mutagenesis 20100701

New trends in nucleoside biotechnology.

Acta naturae 20100701

Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100614

Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100601

Development of therapeutic agents for older patients with acute myelogenous leukemia.

Current opinion in investigational drugs (London, England : 2000) 20100601

Effect of clofarabine on apoptosis and DNA synthesis in human epithelial colon cancer cells.

Nucleosides, nucleotides & nucleic acids 20100601

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20100601

Allogeneic hematopoietic cell transplantation for acute leukemia in first relapse or second remission.

The Korean journal of hematology 20100601

European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100510

Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia.

Pediatric blood & cancer 20100501

Clinical Roundtable Monograph: current treatment options for NHL patients refractory to standard therapy: recent data in single-agent and combination therapy.

Clinical advances in hematology & oncology : H&O 20100501

Fatal neurotoxicity in a patient with down syndrome treated with chemotherapy, irradiation, stem cell transplant, and clofarabine.

Journal of pediatric hematology/oncology 20100401

Novel therapies for myelodysplastic syndromes.

Hematology/oncology clinics of North America 20100401

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20100401

Clofarabine-induced capillary leak syndrome in a child with refractory acute lymphoblastic leukemia.

Journal of pediatric hematology/oncology 20100301

Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100201

Efficient syntheses of clofarabine and gemcitabine from 2-deoxyribonolactone.

Nucleosides, nucleotides & nucleic acids 20100201

Clofarabine in leukemia.

Expert review of hematology 20100201

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents.

Journal of medicinal chemistry 20100114

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20100101

Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights.

Journal of hematology & oncology 20100101

Challenges in treating older patients with acute myeloid leukemia.

Journal of oncology 20100101

Use of clofarabine for acute childhood leukemia.

Biologics : targets & therapy 20100101

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.

Molecular cancer 20100101

Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine.

OncoTargets and therapy 20100101

Clofarabine-based regimen as useful bridge therapy for allogeneic transplantation in myeloid blast crisis of Philadelphia-positive chronic myeloid leukemia resistant to imatinib and dasatinib.

Acta haematologica 20100101

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia.

Molecular cancer 20100101

An update in management of noncutaneous T-cell lymphomas.

Advances in hematology 20100101

Application of new drugs in chronic lymphocytic leukemia.

Mediterranean journal of hematology and infectious diseases 20100101

New treatments for myelodysplastic syndromes.

Mediterranean journal of hematology and infectious diseases 20100101

Clofarabine induces hypomethylation of DNA and expression of Cancer-Testis antigens.

Leukemia research 20091201

Mechanisms of anti-cancer action and pharmacology of clofarabine.

Biochemical pharmacology 20091201

Acute myeloid leukemia and ischemic heart disease successful first line treatment with clofarabine as single agent.

Leukemia research 20091201

A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia.

Leukemia 20091201

Successful combination treatment of clofarabine, cytarabine, and gemtuzumab-ozogamicin in adult refractory B-acute lymphoblastic leukemia.

American journal of hematology 20091201

Clofarabine-based salvage chemotherapy for relapsed or refractory acute leukemia before allogeneic stem cell transplantation: results from a case series.

Leukemia & lymphoma 20091201

Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine.

Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

Last exit clofarabine?

Leukemia & lymphoma 20091201

Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia.

British journal of haematology 20091101

New insights in the management of elderly patients with acute myeloid leukemia.

Current opinion in oncology 20091101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20091101

Advanced Philadelphia chromosome positive acute lymphoblastic leukemia patients relapsed after treatment with tyrosine-kinase inhibitors: successful response to clofarabine and cyclophosphamide.

Haematologica 20091001

Clofarabine: emerging role in leukemias.

Expert opinion on investigational drugs 20091001

Recent progress in the treatment of acute lymphoblastic leukemia: clofarabine.

Hematology/oncology clinics of North America 20091001

Genetic factors influencing cytarabine therapy.

Pharmacogenomics 20091001

Clofarabine for the treatment of adult acute myeloid leukemia.

Future oncology (London, England) 20091001

Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090910

Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine.

Cancer chemotherapy and pharmacology 20090701

Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG.

Bone marrow transplantation 20090701

Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy.

Analytical chemistry 20090701

Clofarabine in relapsed lymphoma: what is the optimal dose?

Leukemia & lymphoma 20090701

Novel therapies for relapsed acute lymphoblastic leukemia.

Current hematologic malignancy reports 20090701

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.

British journal of cancer 20090616

Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3.

American journal of physiology. Renal physiology 20090601

Clofarabine: a new treatment option for patients with acute myeloid leukemia.

Expert opinion on pharmacotherapy 20090601

Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity.

Mini reviews in medicinal chemistry 20090601

Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogs.

International journal of oncology 20090501

Comparison of clofarabine activity in childhood and adult acute leukemia: individual tumor response study.

Anticancer research 20090501

Safety of conditioning agents for allogeneic haematopoietic transplantation.

Expert opinion on drug safety 20090501

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20090501

The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia.

American journal of hematology 20090401

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20090401

Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.

Molecules (Basel, Switzerland) 20090323

Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory, aggressive non-Hodgkin lymphoma.

Leukemia & lymphoma 20090301

Clofarabine: a size that fits all, may not fit all.

Leukemia & lymphoma 20090301

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20090301

Therapy-related acute myelogenous leukemia and myelodysplastic syndrome in patients with acute lymphoblastic leukemia treated with the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimens.

Cancer 20090101

ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.

BMC cancer 20090101

Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin.

Clinical interventions in aging 20090101

Drugs associated with more suicidal ideations are also associated with more suicide attempts.

PloS one 20090101

Managing myelodysplastic symptoms in elderly patients.

Clinical interventions in aging 20090101

Development of fludarabine formulations in the treatment of chronic lymphocytic leukemia.

Drug design, development and therapy 20090101

Clofarabine in refractory Langerhans cell histiocytosis.

Pediatric blood & cancer 20081101

Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.

Clinical advances in hematology & oncology : H&O 20081101

New agents for the treatment of AML recent study findings.

Clinical advances in hematology & oncology : H&O 20081101

Clofarabine combinations as acute myeloid leukemia salvage therapy.

Cancer 20081015

Clofarabine: in search of combinations for the treatment of patients with high-risk acute myeloid leukemia.

Cancer 20081015

Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues.

Leukemia research 20081001

A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome.

Blood 20080901

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

Molecular cancer therapeutics 20080901

Acute myeloid leukemia in the elderly.

Seminars in oncology 20080801

New drugs in acute myeloid leukemia.

Seminars in oncology 20080801

Synthetic studies on formamidopyrimidines related to clofarabine.

Nucleosides, nucleotides & nucleic acids 20080801

Acute myeloid leukemia in the elderly: conventional and novel treatment approaches.

Blood reviews 20080701

Novel purine nucleoside analogues for hematological malignancies.

Recent patents on anti-cancer drug discovery 20080601

Cytotoxic activities of nucleoside and nucleobase analog drugs in malignant mesothelioma: characterization of a novel nucleobase transport activity.

Biochemical pharmacology 20080515

Fatal skin and liver toxicity in a patient treated with clofarabine.

Pediatric blood & cancer 20080501

Treating refractory leukemias in childhood, role of clofarabine.

Therapeutics and clinical risk management 20080401

Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia.

Current opinion in hematology 20080301

Clofarabine acts as radiosensitizer in vitro and in vivo by interfering with DNA damage response.

International journal of radiation oncology, biology, physics 20080101

The combination of clofarabine and cytarabine in pediatric relapsed acute lymphoblastic leukemia: a case report.

Chemotherapy 20080101

Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.

Current medicinal chemistry 20080101

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

The Journal of pharmacology and experimental therapeutics 20071201

Three new drugs for acute lymphoblastic leukemia: nelarabine, clofarabine, and forodesine.

Seminars in oncology 20071201

Clofarabine: new drug. Children with acute lymphoblastic leukaemia: a last resort.

Prescrire international 20071201

Clofarabine: past, present, and future.

Leukemia & lymphoma 20071001

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias.

Blood 20070915

Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemia.

Journal of pediatric hematology/oncology 20070901

Saccharomyces cerevisiae emboli in an immunocompromised patient with relapsed acute myeloid leukaemia.

Clinical and experimental dermatology 20070701

Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma.

Journal of pharmaceutical and biomedical analysis 20070628

Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes.

Biochemical and biophysical research communications 20070615

In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia.

British journal of haematology 20070401

Advances in the management of AML in the elderly.

Clinical advances in hematology & oncology : H&O 20070301

Clofarabine for the treatment of acute lymphoblastic leukemia.

Expert review of anticancer therapy 20070201

Nursing considerations for clofarabine in the treatment of acute lymphoblastic leukemia in children.

Clinical journal of oncology nursing 20061201

Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.

The Yale journal of biology and medicine 20061201

Clofarabine and nelarabine: two new purine nucleoside analogs.

Current opinion in oncology 20061101

The activity and toxicity of low dose clofarabine against relapsed or refractory myeloma.

Haematologica 20061101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20061101

Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

Nature reviews. Drug discovery 20061001

A tale of two drugs.

Nature reviews. Drug discovery 20061001

New directions in the treatment of mantle cell lymphoma: an overview.

Clinical lymphoma & myeloma 20061001

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20061001

Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older.

Blood 20060701

Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research 20060701

Pharmacological and clinical studies on purine nucleoside analogs--new anticancer agents.

Mini reviews in medicinal chemistry 20060501

Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060420

Treatment of older patients with acute myeloid leukemia--new agents.

Seminars in hematology 20060401

The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.

Acta crystallographica. Section D, Biological crystallography 20060201

New drugs 06, part I.

Nursing 20060201

A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems.

Molecular pharmacology 20060101

New agents for the treatment of acute myeloid leukemia.

Best practice & research. Clinical haematology 20060101

Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity.

Current medicinal chemistry 20060101

Pediatric drug trials facing some obstacles.

Journal of the National Cancer Institute 20051207

Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review.

Expert opinion on pharmacotherapy 20051201

New agents in the treatment of childhood leukemias and myelodysplastic syndromes.

Current oncology reports 20051101

Purine nucleoside analogues for the treatment of hematological malignancies: pharmacology and clinical applications.

Current cancer drug targets 20050901

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20050901

Plasma and cerebrospinal fluid pharmacokinetics of clofarabine in nonhuman primates.

Clinical cancer research : an official journal of the American Association for Cancer Research 20050815

The distribution, metabolism, and elimination of clofarabine in rats.

Drug metabolism and disposition: the biological fate of chemicals 20050601

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20050601

The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog.

Cancer 20050515

Clofarabine.

Nature reviews. Drug discovery 20050501

Clofarabine.

Nature reviews. Drug discovery 20050501

Biochemical modulation of cytarabine triphosphate by clofarabine.

Cancer chemotherapy and pharmacology 20050401

Complete remission following clofarabine treatment in refractory juvenile myelomonocytic leukemia.

Journal of pediatric hematology/oncology 20050301

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias.

Blood 20050201

New drugs and dosage forms.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050201

Clofarabine: in pediatric patients with acute lymphoblastic leukemia.

Paediatric drugs 20050101

New drugs: tigecycline, ziconotide, and clofarabine.

Journal of the American Pharmacists Association : JAPhA 20050101

Nucleosides as anticancer agents: from concept to the clinic.

Nucleic acids symposium series (2004) 20050101

Nucleoside analogs and antimetabolite therapies for myelodysplastic syndrome.

Best practice & research. Clinical haematology 20041201

Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia.

Journal of clinical pharmacology 20041101

Bibliography. Current world literature. Therapeutic modalities.

Current opinion in oncology 20041101

Clofarabine in adult acute leukemias: clinical success and pharmacokinetics.

Nucleosides, nucleotides & nucleic acids 20041001

In vitro assessment of nucleoside analogs in multiple myeloma.

Cancer chemotherapy and pharmacology 20040801

Prognostic factors and therapeutic options for relapsed or refractory acute myeloid leukemia.

Haematologica 20040801

Purine nucleoside antimetabolites in development for the treatment of cancer.

Current opinion in investigational drugs (London, England : 2000) 20040601

Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia.

Blood 20040201

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20040101

Clofarabine.

Drugs in R&D 20040101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20040101

New nucleoside analogs in the treatment of hematological disorders.

Acta poloniae pharmaceutica 20040101

New nucleoside analogs in the treatment of solid tumors.

Acta poloniae pharmaceutica 20040101

Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias.

Clinical cancer research : an official journal of the American Association for Cancer Research 20031215

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20031201

Clofarabine. Bioenvision/ILEX.

Current opinion in investigational drugs (London, England : 2000) 20031201

Induction of complete remission using single agent clofarabine in a patient with primary refractory acute myeloblaste leukemia.

Leukemia & lymphoma 20031201

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20031101

Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia.

Blood 20031001

Clofarabine-induced acral erythema during the treatment of patients with myelodysplasia and acute leukemia: report of two cases.

Leukemia & lymphoma 20030801

New designs for phase 2 clinical trials.

Blood 20030715

Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315

Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia.

Haematologica 20030301

Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.

Biochemical pharmacology 20030115

Advanced-phase chronic myeloid leukemia.

Seminars in hematology 20030101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20030101

New drugs in acute myeloid leukemia.

Current oncology reports 20020901

Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM.

Cancer chemotherapy and pharmacology 20020901

Hematologic malignancies: new developments and future treatments.

Seminars in oncology 20020801

Gateways to Clinical Trials.

Methods and findings in experimental and clinical pharmacology 20020401

DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine.

Clinical cancer research : an official journal of the American Association for Cancer Research 20011101

Nucleoside analogues in the treatment of haematological malignancies.

Expert opinion on pharmacotherapy 20010601

Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.

Journal of medicinal chemistry 19920124

Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.

Cancer research 19910501