N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-1,3-benzodiazol-5-yl)pyrimidin-2-amine
| Title | Journal |
|---|---|
| A Population Pharmacokinetic and Pharmacodynamic Analysis of Abemaciclib in a Phase I Clinical Trial in Cancer Patients. | Clinical pharmacokinetics 20180101 |
| Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors. | Cancer discovery 20160701 |
| Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours. | British journal of cancer 20160315 |
| Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors. | Cancer cell 20160314 |
| Targeting the cyclin D-cyclin-dependent kinase (CDK) 4/6-retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions. | Discovery medicine 20160101 |
| Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft. | Drug metabolism and disposition: the biological fate of chemicals 20150901 |
| A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. | Cancer biology & therapy 20130701 |
| The requirement for cyclin D function in tumor maintenance. | Cancer cell 20121016 |
| Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. | Cancer cell 20121016 |
| Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. | Cell cycle (Georgetown, Tex.) 20120715 |
| A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. | Cancer cell 20100713 |
| The landscape of somatic copy-number alteration across human cancers. | Nature 20100218 |