4-Octadecene-1,3-diol, 2-amino-, (2S,3R,4E)-
| Title | Journal |
|---|---|
| Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. | Archives of toxicology 20170201 |
| Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. | British journal of pharmacology 20170101 |
| Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects. | Toxicological sciences : an official journal of the Society of Toxicology 20160301 |
| A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. | Chemico-biological interactions 20150725 |
| FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. | Toxicology letters 20150702 |
| Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150601 |
| FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction. | Molecular pharmacology 20150601 |
| Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. | Journal of lipid research 20150601 |
| Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. | Chemico-biological interactions 20150525 |
| Lysophospholipid receptors in drug discovery. | Experimental cell research 20150501 |
| Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | Journal of neuroinflammation 20150101 |
| Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway. | International journal of clinical and experimental pathology 20150101 |
| Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. | Neurotoxicology 20140901 |
| Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | Molecular neurobiology 20140801 |
| FTY720 attenuates paraquat-induced lung injury in mice. | International immunopharmacology 20140801 |
| Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | Nature neuroscience 20140701 |
| ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. | PloS one 20140101 |
| Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. | Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20130601 |
| Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3. | Journal of immunology (Baltimore, Md. : 1950) 20130401 |
| Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. | Analytical biochemistry 20130315 |
| Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. | British journal of pharmacology 20130301 |
| Early tolerability and safety of fingolimod in clinical practice. | Journal of the neurological sciences 20121215 |
| Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. | European journal of pharmacology 20121205 |
| Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway. | Biochimie 20121201 |
| Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. | Molecular and cellular biochemistry 20121201 |
| Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | International journal of molecular medicine 20121201 |
| Effect of alkyl chain length on sphingosine kinase 2 selectivity. | Bioorganic & medicinal chemistry letters 20121115 |
| Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. | International journal of cancer 20121101 |
| Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases. | Multiple sclerosis (Houndmills, Basingstoke, England) 20121101 |
| Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121101 |
| Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal. | Multiple sclerosis (Houndmills, Basingstoke, England) 20121101 |
| Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. | The Biochemical journal 20121101 |
| Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. | Journal of neurochemistry 20121101 |
| A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | Bioresource technology 20121101 |
| Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | Basic research in cardiology 20121101 |
| Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. | Endocrinology 20121101 |
| High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | Arteriosclerosis, thrombosis, and vascular biology 20121101 |
| Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings. | Multiple sclerosis (Houndmills, Basingstoke, England) 20121101 |
| Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod. | Multiple sclerosis (Houndmills, Basingstoke, England) 20121101 |
| Focus on molecules: Sphingosine 1 Phosphate (S1P). | Experimental eye research 20121001 |
| Sudden unexpected death on fingolimod. | Multiple sclerosis (Houndmills, Basingstoke, England) 20121001 |
| Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome. | The Journal of surgical research 20121001 |
| Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat. | Pancreas 20121001 |
| Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway. | Archives of dermatological research 20121001 |
| Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells. | Journal of neuroscience research 20121001 |
| Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus. | Journal of clinical immunology 20121001 |
| Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | Prostaglandins & other lipid mediators 20121001 |
| Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. | Biochimica et biophysica acta 20121001 |
| Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. | The Biochemical journal 20121001 |
| New disease-modifying therapies and new challenges for MS. | Current neurology and neuroscience reports 20121001 |
| Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. | Fertility and sterility 20121001 |
| Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. | Archives of biochemistry and biophysics 20121001 |
| Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. | American journal of physiology. Heart and circulatory physiology 20121001 |
| Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | The Journal of clinical endocrinology and metabolism 20121001 |
| Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | Endocrine-related cancer 20121001 |
| A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | Therapeutic advances in cardiovascular disease 20121001 |
| The functional roles of S1P in immunity. | Journal of biochemistry 20121001 |
| Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose. | Carbohydrate research 20121001 |
| Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. | Birth defects research. Part A, Clinical and molecular teratology 20121001 |
| Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. | Heart failure clinics 20121001 |
| Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120926 |
| Diastereodivergent hydroxyfluorination of cyclic and acyclic allylic amines: synthesis of 4-deoxy-4-fluorophytosphingosines. | The Journal of organic chemistry 20120907 |
| The safety risks of innovation: the FDA's Expedited Drug Development Pathway. | JAMA 20120905 |
| A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis. | Multiple sclerosis (Houndmills, Basingstoke, England) 20120901 |
| Evaluation of pathological effects in broilers during fumonisins and clays exposure. | Mycopathologia 20120901 |
| A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart? | Cardiovascular toxicology 20120901 |
| Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case. | Traffic (Copenhagen, Denmark) 20120901 |
| The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901 |
| Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes. | Glia 20120901 |
| Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. | Journal of neurophysiology 20120901 |
| The hydrophobic mismatch determines the miscibility of ceramides in lipid monolayers. | Chemistry and physics of lipids 20120901 |
| 4-aminopyridine toxicity: a case report and review of the literature. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901 |
| First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. | Molecular cancer therapeutics 20120901 |
| Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. | Acta neuropathologica 20120901 |
| Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | Lipids 20120901 |
| Reporting of subgroup analyses from clinical trials. | The Lancet. Neurology 20120901 |
| The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. | Lymphatic research and biology 20120901 |
| Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. | Chemistry & biology 20120824 |
| Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice. | Vascular pharmacology 20120819 |
| Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. | Cell 20120817 |
| S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. | Blood 20120816 |
| [Infections and fingolimod]. | Revista de neurologia 20120816 |
| Ethylene signaling pathway and MAPK cascades are required for AAL toxin-induced programmed cell death. | Molecular plant-microbe interactions : MPMI 20120801 |
| PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation. | Molecular and cellular biochemistry 20120801 |
| Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease. | Human molecular genetics 20120801 |
| Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor. | The Journal of pharmacology and experimental therapeutics 20120801 |
| Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo. | Transplant immunology 20120801 |
| Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. | Journal of lipid research 20120801 |
| A fluorescent assay for ceramide synthase activity. | Journal of lipid research 20120801 |
| Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | The Journal of clinical endocrinology and metabolism 20120801 |
| Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | The American journal of pathology 20120801 |
| Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | EMBO molecular medicine 20120801 |
| Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. | Stroke 20120801 |
| Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results. | International journal of clinical pharmacology and therapeutics 20120801 |
| Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. | Investigative ophthalmology & visual science 20120801 |
| Labeling Golgi with fluorescent ceramides. | Cold Spring Harbor protocols 20120801 |
| Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis. | International journal of rheumatic diseases 20120801 |
| [Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils]. | Zhongguo shi yan xue ye xue za zhi 20120801 |
| The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. | Biochemical and biophysical research communications 20120720 |
| Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. | Proceedings of the American Thoracic Society 20120715 |
| Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. | Circulation 20120710 |
| Population pharmacokinetics of fingolimod phosphate in healthy participants. | Journal of clinical pharmacology 20120701 |
| Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model. | Breast cancer research and treatment 20120701 |
| The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists. | Xenobiotica; the fate of foreign compounds in biological systems 20120701 |
| A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | Leukemia 20120701 |
| Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases. | Metabolic engineering 20120701 |
| Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge? | International journal of pharmaceutics 20120701 |
| IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. | American journal of physiology. Lung cellular and molecular physiology 20120701 |
| The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro. | International journal of molecular medicine 20120701 |
| The role of sphingosine-1-phosphate transporter Spns2 in immune system function. | Journal of immunology (Baltimore, Md. : 1950) 20120701 |
| [Basic mechanisms of action of fingolimod in relation to multiple sclerosis]. | Revista de neurologia 20120701 |
| Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | Clinical nephrology 20120701 |
| Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis. | Clinical therapeutics 20120701 |
| Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. | Journal of Zhejiang University. Science. B 20120701 |
| [Effect of ceramide on GSTA1 in Caco-2 cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20120701 |
| [Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice]. | Arerugi = [Allergy] 20120701 |
| Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. | Cancer letters 20120628 |
| Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation. | Biochemical and biophysical research communications 20120622 |
| Species-specific activity of glycolipid ligands for invariant NKT cells. | Chembiochem : a European journal of chemical biology 20120618 |
| First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview. | Drugs 20120618 |
| Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. | Biochemical and biophysical research communications 20120615 |
| In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. | Journal of controlled release : official journal of the Controlled Release Society 20120610 |
| Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. | Circulation 20120605 |
| Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. | Circulation 20120605 |
| SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration. | The Journal of surgical research 20120601 |
| Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. | British journal of pharmacology 20120601 |
| Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome. | Endocrine 20120601 |
| FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase. | British journal of pharmacology 20120601 |
| Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. | Journal of cellular biochemistry 20120601 |
| Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | Advances in medical sciences 20120601 |
| H-Ras increases release of sphingosine resulting in down-regulation of TSP-1 in non-transformed cells. | International journal of experimental pathology 20120601 |
| Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. | Coronary artery disease 20120601 |
| Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. | Allergology international : official journal of the Japanese Society of Allergology 20120601 |
| Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. | Cardiovascular drugs and therapy 20120601 |
| Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain. | Journal of neurochemistry 20120601 |
| FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601 |
| Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. | Angiogenesis 20120601 |
| Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle. | Allergology international : official journal of the Japanese Society of Allergology 20120601 |
| Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | Neurochemical research 20120601 |
| Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. | Journal of lipid research 20120601 |
| IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model. | Pulmonary pharmacology & therapeutics 20120601 |
| Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. | Critical care medicine 20120601 |
| Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis. | Development (Cambridge, England) 20120601 |
| Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. | Analytical and bioanalytical chemistry 20120601 |
| [Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials]. | Ideggyogyaszati szemle 20120530 |
| The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment. | Transplantation 20120527 |
| The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. | Molecular cell 20120525 |
| Structure of the first sphingosine 1-phosphate receptor. | Science signaling 20120522 |
| FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells. | Neuroscience letters 20120516 |
| Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. | The Biochemical journal 20120515 |
| Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible. | American journal of physiology. Heart and circulatory physiology 20120515 |
| Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. | Journal of neuroimmunology 20120515 |
| Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways. | Journal of immunology (Baltimore, Md. : 1950) 20120515 |
| Building a better sphingosine kinase-1 inhibitor. | The Biochemical journal 20120515 |
| [Multiple sclerosis: beyong first line therapies]. | Revue medicale suisse 20120502 |
| Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. | Kidney international 20120501 |
| Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. | Journal of cell science 20120501 |
| Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells. | International journal of oncology 20120501 |
| S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. | Experimental cell research 20120501 |
| Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. | Cancer biology & therapy 20120501 |
| Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. | Neurochemistry international 20120501 |
| Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. | Molecular endocrinology (Baltimore, Md.) 20120501 |
| An efficient synthesis of the polar part of sulfamisterin and its analogs. | Carbohydrate research 20120501 |
| Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod. | Current medical research and opinion 20120501 |
| Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. | Journal of neuropathology and experimental neurology 20120501 |
| MS clinical trials: what can subgroup analyses teach us? | The Lancet. Neurology 20120501 |
| Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study. | The Lancet. Neurology 20120501 |
| Harnessing regulatory T cells for therapeutic purposes. | Kidney international 20120501 |
| Immunotherapies in neurologic disorders. | The Medical clinics of North America 20120501 |
| Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. | Nature 20120426 |
| Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. | Oncogene 20120419 |
| [New disease-modifying and symptomatic therapies for multiple sclerosis]. | MMW Fortschritte der Medizin 20120419 |
| Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. | American journal of physiology. Lung cellular and molecular physiology 20120415 |
| Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. | The Journal of biological chemistry 20120413 |
| Drugs: An injection of hope. | Nature 20120412 |
| Autophagy induced by FTY720 promotes apoptosis in U266 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411 |
| CCR7/CCL19 controls expression of EDG-1 in T cells. | The Journal of biological chemistry 20120406 |
| The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. | The Journal of clinical investigation 20120402 |
| Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis. | European journal of clinical pharmacology 20120401 |
| Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers. | European journal of clinical pharmacology 20120401 |
| Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. | Journal of cellular biochemistry 20120401 |
| Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. | Molecular and cellular biochemistry 20120401 |
| Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. | Molecular and cellular biochemistry 20120401 |
| Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans. | Cellular microbiology 20120401 |
| Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics. | The Journal of pathology 20120401 |
| A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. | International journal of biological macromolecules 20120401 |
| Pharmacological mechanisms of black cohosh in Sprague-Dawley rats. | Fitoterapia 20120401 |
| Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling. | The New phytologist 20120401 |
| Sphingosine pathway deregulation in endometriotic tissues. | Fertility and sterility 20120401 |
| Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries. | Arteriosclerosis, thrombosis, and vascular biology 20120401 |
| Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. | Experimental cell research 20120401 |
| Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. | The American journal of pathology 20120401 |
| An efficient and convenient formal synthesis of Jaspine B from D-xylose. | Carbohydrate research 20120401 |
| Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. | Neuro-oncology 20120401 |
| Evidence that sphingolipid signaling is involved in responding to low temperature. | The New phytologist 20120401 |
| Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer. | Bioorganic & medicinal chemistry letters 20120401 |
| FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms. | The American journal of pathology 20120401 |
| Network analysis of randomized controlled trials in multiple sclerosis. | Clinical therapeutics 20120401 |
| [2012: Update on diagnosis and treatment of multiple sclerosis]. | Deutsche medizinische Wochenschrift (1946) 20120401 |
| Fingolimod: cardiovascular deaths. | Prescrire international 20120401 |
| Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis. | Future medicinal chemistry 20120401 |
| Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. | The Journal of biological chemistry 20120323 |
| Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis. | Biochemical and biophysical research communications 20120323 |
| Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence? | Neurology 20120320 |
| S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. | Blood 20120315 |
| Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. | European journal of pharmacology 20120315 |
| Synthesis of amino core compounds of galactosyl phytosyl ceramide analogs for developing iNKT-cell inducers. | Molecules (Basel, Switzerland) 20120312 |
| Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. | The Journal of biological chemistry 20120309 |
| Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. | Biochemical and biophysical research communications 20120309 |
| Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation. | Cell and tissue research 20120301 |
| Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages. | European journal of immunology 20120301 |
| High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii. | Metabolic engineering 20120301 |
| Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. | The American journal of pathology 20120301 |
| Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation. | Transplant immunology 20120301 |
| Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves. | Cardiovascular research 20120301 |
| Targeting sphingosine kinase-1 to inhibit melanoma. | Pigment cell & melanoma research 20120301 |
| Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes. | Plant molecular biology 20120301 |
| Terpene alcohols inhibit de novo sphingolipid biosynthesis. | Planta medica 20120301 |
| Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120301 |
| LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301 |
| FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment? | Autophagy 20120301 |
| FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. | Multiple sclerosis (Houndmills, Basingstoke, England) 20120301 |
| Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. | Blood 20120301 |
| [Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120301 |
| [Ca2+ and sphingolipids as modulators for apoptosis and cancer]. | Investigacion clinica 20120301 |
| Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys. | Avian diseases 20120301 |
| Immunological function of sphingosine 1-phosphate in the intestine. | Nutrients 20120301 |
| Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells. | Experimental & molecular medicine 20120227 |
| Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. | British journal of cancer 20120227 |
| Fingolimod-associated macular edema: incidence, detection, and management. | Neurology 20120227 |
| Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug. | BMJ (Clinical research ed.) 20120223 |
| ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. | Clinica chimica acta; international journal of clinical chemistry 20120218 |
| FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2). | The Journal of biological chemistry 20120217 |
| Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. | Developmental biology 20120215 |
| Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | Oncogene 20120202 |
| Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase. | Inflammation 20120201 |
| Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. | Acta physiologica (Oxford, England) 20120201 |
| Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | International journal of cancer 20120201 |
| Integration of transient receptor potential canonical channels with lipids. | Acta physiologica (Oxford, England) 20120201 |
| Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis. | British journal of pharmacology 20120201 |
| Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue? | British journal of pharmacology 20120201 |
| [Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations]. | Der Nervenarzt 20120201 |
| Inhibitors of specific ceramide synthases. | Biochimie 20120201 |
| Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | Neuropharmacology 20120201 |
| Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions. | Biochimica et biophysica acta 20120201 |
| S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. | Molecular pharmacology 20120201 |
| Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. | Journal of the American Society of Nephrology : JASN 20120201 |
| Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. | Thorax 20120201 |
| Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier. | The American journal of pathology 20120201 |
| Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. | Archives of biochemistry and biophysics 20120201 |
| Immune regulation by sphingosine 1-phosphate and its receptors. | Archivum immunologiae et therapiae experimentalis 20120201 |
| Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. | Biochimica et biophysica acta 20120201 |
| Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. | Reproductive biomedicine online 20120201 |
| Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. | Journal of dermatological science 20120201 |
| Does fingolimod in multiple sclerosis patients cause macular edema? | Journal of neurology 20120201 |
| Sphingosine 1-phosphate signalling in cancer. | Biochemical Society transactions 20120201 |
| Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. | Cell cycle (Georgetown, Tex.) 20120201 |
| Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. | Chemistry and physics of lipids 20120201 |
| Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. | Journal of separation science 20120201 |
| Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | Cancer research 20120201 |
| Fingolimod for multiple sclerosis. | Drug and therapeutics bulletin 20120201 |
| Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment. | Archives of neurology 20120201 |
| Synthesis and immunomodulating activity of new analogues of fingolimod. | Archiv der Pharmazie 20120201 |
| [Role of S1P acting both inside and outside the cells]. | Seikagaku. The Journal of Japanese Biochemical Society 20120201 |
| [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120201 |
| Fingolimod for multiple sclerosis. | The New England journal of medicine 20120126 |
| Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20120125 |
| Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. | Blood 20120119 |
| PBSCs Sphingoling along S1P/S1P1 axis. | Blood 20120119 |
| Bioactive lipids from the sponge Spirastrella abata. | Bioorganic & medicinal chemistry letters 20120115 |
| [Neurology]. | Revue medicale suisse 20120111 |
| Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. | Molecular and cellular endocrinology 20120102 |
| Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. | Clinical immunology (Orlando, Fla.) 20120101 |
| Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | Journal of hepatology 20120101 |
| Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | Leukemia 20120101 |
| Sphingosine 1-phosphate in coagulation and inflammation. | Seminars in immunopathology 20120101 |
| The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis. | Molecular biology reports 20120101 |
| Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists. | Cellular signalling 20120101 |
| Nuclear sphingolipid metabolism. | Annual review of physiology 20120101 |
| Role of FAK in S1P-regulated endothelial permeability. | Microvascular research 20120101 |
| Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts. | Cellular signalling 20120101 |
| The natural cardioprotective particle HDL modulates connexin43 gap junction channels. | Cardiovascular research 20120101 |
| Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. | American journal of respiratory and critical care medicine 20120101 |
| Sphingosine-1-phosphate signaling and its role in disease. | Trends in cell biology 20120101 |
| CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | The American journal of pathology 20120101 |
| Sphingosine in plants--more riddles from the Sphinx? | The New phytologist 20120101 |
| Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold. | Bioorganic & medicinal chemistry letters 20120101 |
| Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. | Journal of immunology (Baltimore, Md. : 1950) 20120101 |
| Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. | Bioorganic & medicinal chemistry 20120101 |
| Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. | Acta pharmacologica Sinica 20120101 |
| Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder. | Multiple sclerosis (Houndmills, Basingstoke, England) 20120101 |
| Clinical pharmacokinetics of fingolimod. | Clinical pharmacokinetics 20120101 |
| Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. | Annual review of immunology 20120101 |
| Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold. | Bioorganic & medicinal chemistry letters 20120101 |
| Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. | Cellular immunology 20120101 |
| Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. | Molecular and biochemical parasitology 20120101 |
| The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. | Current pharmaceutical design 20120101 |
| Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. | PloS one 20120101 |
| FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells. | PloS one 20120101 |
| Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | Indian journal of ophthalmology 20120101 |
| [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists]. | Yao xue xue bao = Acta pharmaceutica Sinica 20120101 |
| Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | Cellular immunology 20120101 |
| Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice. | Molecular vision 20120101 |
| Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Isoform-selective assays for sphingosine kinase activity. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| A cleanup method for mass spectrometry of sphingosine-1-phosphate in blood and solid tissues using a phosphate capture molecule. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Sphingosine-1-phosphate signaling in skeletal muscle cells. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Sphingosine-1-phosphate signaling in neural progenitors. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | PloS one 20120101 |
| Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine. | PloS one 20120101 |
| Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia. | PloS one 20120101 |
| Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. | PloS one 20120101 |
| Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | PloS one 20120101 |
| Sphingosine-1-phosphate signaling in physiology and diseases. | BioFactors (Oxford, England) 20120101 |
| Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells. | Clinical and experimental obstetrics & gynecology 20120101 |
| [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101 |
| The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. | PloS one 20120101 |
| Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro. | PloS one 20120101 |
| Oral FTY720 administration induces immune tolerance and inhibits early development of atherosclerosis in apolipoprotein E-deficient mice. | International journal of immunopathology and pharmacology 20120101 |
| Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | PloS one 20120101 |
| Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice. | International journal of molecular sciences 20120101 |
| Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. | PloS one 20120101 |
| Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | PloS one 20120101 |
| Therapeutic approach to steroid-resistant dermatitis using novel immunomodulator FTY720 (Fingolimod) in combination with betamethasone ointment in NC/Nga mice. | Biological & pharmaceutical bulletin 20120101 |
| The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells. | Biological & pharmaceutical bulletin 20120101 |
| Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis. | Pharmaceutical statistics 20120101 |
| Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach. | Drug design, development and therapy 20120101 |
| Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group. | Wiener medizinische Wochenschrift (1946) 20120101 |
| 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin. | Lipids in health and disease 20120101 |
| [Changes in content of glycolipids, sphingosine and cytokines in the rat brain with experimental edema]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101 |
| Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A. | PloS one 20120101 |
| Synthesis of a key intermediate for the preparation of FTY720 analogs. | Chemical & pharmaceutical bulletin 20120101 |
| Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. | The Journal of biological chemistry 20111230 |
| FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. | Blood 20111222 |
| Effects of sphingosine 2N- and 3O-methylation on palmitoyl ceramide properties in bilayer membranes. | Biophysical journal 20111221 |
| Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. | The Biochemical journal 20111215 |
| The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications. | European journal of pharmacology 20111215 |
| Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. | Circulation 20111213 |
| Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. | The Journal of biological chemistry 20111209 |
| Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives. | Organic & biomolecular chemistry 20111207 |
| Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. | Clinical science (London, England : 1979) 20111201 |
| ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium. | Cellular signalling 20111201 |
| Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. | Biochimica et biophysica acta 20111201 |
| Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. | Cellular signalling 20111201 |
| Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana. | The New phytologist 20111201 |
| Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. | Pharmacology & therapeutics 20111201 |
| Integral hair lipid in human hair follicle. | Journal of dermatological science 20111201 |
| Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier. | Arteriosclerosis, thrombosis, and vascular biology 20111201 |
| Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism. | Atherosclerosis 20111201 |
| Complex modulation of peptidolytic activity of cathepsin D by sphingolipids. | Biochimica et biophysica acta 20111201 |
| Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | Molecular endocrinology (Baltimore, Md.) 20111201 |
| Extracellular and intracellular sphingosine-1-phosphate in cancer. | Cancer metastasis reviews 20111201 |
| Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. | Molecular endocrinology (Baltimore, Md.) 20111201 |
| Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. | The Journal of pathology 20111201 |
| The debut of a rational treatment for an inherited neuropathy? | The Journal of clinical investigation 20111201 |
| Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. | The Journal of clinical investigation 20111201 |
| [Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology]. | Clinical calcium 20111201 |
| Role of the sphingosine rheostat in the regulation of cnidarian-dinoflagellate symbioses. | The Biological bulletin 20111201 |
| Cardioprotective role of sphingosine-1-phosphate. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20111201 |
| Setting the clock for recirculating lymphocytes. | Science signaling 20111108 |
| Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction. | Journal of cellular and molecular medicine 20111101 |
| Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells. | Journal of cellular physiology 20111101 |
| Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | Acta physiologica (Oxford, England) 20111101 |
| FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. | American journal of reproductive immunology (New York, N.Y. : 1989) 20111101 |
| Delayed fingolimod-associated asystole. | Multiple sclerosis (Houndmills, Basingstoke, England) 20111101 |
| Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. | Neurochemical research 20111101 |
| Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. | Anti-cancer agents in medicinal chemistry 20111101 |
| Hypoxia-inducible factors and sphingosine 1-phosphate signaling. | Anti-cancer agents in medicinal chemistry 20111101 |
| Regulation of autophagy by sphingolipids. | Anti-cancer agents in medicinal chemistry 20111101 |
| S1P regulation of macrophage functions in the context of cancer. | Anti-cancer agents in medicinal chemistry 20111101 |
| Targeting sphingosine-1-phosphate receptors in cancer. | Anti-cancer agents in medicinal chemistry 20111101 |
| Targeting sphingosine-1-phosphate in hematologic malignancies. | Anti-cancer agents in medicinal chemistry 20111101 |
| Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study. | Multiple sclerosis (Houndmills, Basingstoke, England) 20111101 |
| Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. | Journal of cellular biochemistry 20111101 |
| Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions. | Experimental dermatology 20111101 |
| Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101 |
| The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death. | Journal of experimental botany 20111101 |
| FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101 |
| Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. | Cancer research 20111101 |
| Background and rationale for mechanism of action, efficacy, and safety of fingolimod (Gilenya), the first oral therapy for remitting-relapsing multiple sclerosis: with special emphasis upon visual safety. | Current opinion in ophthalmology 20111101 |
| Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols. | European journal of medicinal chemistry 20111101 |
| A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection. | Basic research in cardiology 20111101 |
| Oral treatment for multiple sclerosis. | The Lancet. Neurology 20111101 |
| Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat. | Transplantation proceedings 20111101 |
| [Multiple sclerosis: current therapies and future perspectives]. | Nihon rinsho. Japanese journal of clinical medicine 20111101 |
| C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides. | Molecules and cells 20111031 |
| Syntheses of sulfur and selenium analogues of pachastrissamine via double displacements of cyclic sulfate. | Organic & biomolecular chemistry 20111021 |
| Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. | Chemical reviews 20111012 |
| Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts. | The Journal of biological chemistry 20111007 |
| Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation. | Cell biology international 20111001 |
| Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. | Cellular and molecular neurobiology 20111001 |
| (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. | Cellular signalling 20111001 |
| G-protein-coupled receptors in control of natural killer cell migration. | Trends in immunology 20111001 |
| Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. | Journal of clinical immunology 20111001 |
| Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. | American journal of physiology. Heart and circulatory physiology 20111001 |
| Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001 |
| GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. | Cell calcium 20111001 |
| Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats. | Diabetes research and clinical practice 20111001 |
| Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions. | Current neurology and neuroscience reports 20111001 |
| Mechanisms involved in α1B-adrenoceptor desensitization. | IUBMB life 20111001 |
| The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | Critical reviews in biochemistry and molecular biology 20111001 |
| The role of sphingolipids in respiratory disease. | Therapeutic advances in respiratory disease 20111001 |
| Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. | Plant signaling & behavior 20111001 |
| Fingolimod treatment for multiple sclerosis patients What do we do with varicella? | Annals of neurology 20111001 |
| [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111001 |
| GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | Science (New York, N.Y.) 20110930 |
| A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose. | Carbohydrate research 20110927 |
| Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. | Biochemical and biophysical research communications 20110923 |
| The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo. | Biochemical and biophysical research communications 20110923 |
| The effect of FTY720 in the Theiler's virus model of multiple sclerosis. | Journal of the neurological sciences 20110915 |
| Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C. | Bioorganic & medicinal chemistry 20110915 |
| Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer. | Nature reviews. Urology 20110913 |
| Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. | Blood 20110908 |
| FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2. | The Journal of biological chemistry 20110902 |
| There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. | Neurochemical research 20110901 |
| The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice. | Autoimmunity 20110901 |
| MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | The New phytologist 20110901 |
| TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720. | International immunopharmacology 20110901 |
| Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c. | Journal of cellular physiology 20110901 |
| Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. | Journal of cellular physiology 20110901 |
| P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels. | American journal of physiology. Heart and circulatory physiology 20110901 |
| PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. | Protein science : a publication of the Protein Society 20110901 |
| Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. | American journal of physiology. Cell physiology 20110901 |
| Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. | Molecular and cellular neurosciences 20110901 |
| FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. | Journal of immunology (Baltimore, Md. : 1950) 20110901 |
| Branch retinal vein occlusion during fingolimod treatment in a patient with multiple sclerosis. | Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20110901 |
| New insights into cell death induced by long chain bases in Arabidopsis. | The New phytologist 20110901 |
| Post-translational modification of 14-3-3 isoforms and regulation of cellular function. | Seminars in cell & developmental biology 20110901 |
| A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya). | Discovery medicine 20110901 |
| Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. | The Journal of biological chemistry 20110826 |
| NICE rules out NHS prescription of fingolimod for multiple sclerosis. | BMJ (Clinical research ed.) 20110810 |
| Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. | Molecular biology reports 20110801 |
| Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. | American journal of respiratory cell and molecular biology 20110801 |
| Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. | Cell death and differentiation 20110801 |
| Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model. | Digestive diseases and sciences 20110801 |
| The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice. | Pulmonary pharmacology & therapeutics 20110801 |
| Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis. | Multiple sclerosis (Houndmills, Basingstoke, England) 20110801 |
| Translational aspects of sphingosine 1-phosphate biology. | Trends in molecular medicine 20110801 |
| Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol. | Biochimica et biophysica acta 20110801 |
| Sphingolipid modulation of angiogenic factor expression in neuroblastoma. | Cancer prevention research (Philadelphia, Pa.) 20110801 |
| Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. | Journal of neurochemistry 20110801 |
| Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110801 |
| Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. | Cell proliferation 20110801 |
| Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis. | International journal of clinical practice 20110801 |
| Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B. | Current opinion in chemical biology 20110801 |
| Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases. | Cell calcium 20110801 |
| Activation of matriptase zymogen. | Journal of biochemistry 20110801 |
| Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. | Critical reviews in biochemistry and molecular biology 20110801 |
| Fingolimod: a review of its use in the management of relapsing-remitting multiple sclerosis. | CNS drugs 20110801 |
| Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. | Archives of dermatology 20110801 |
| Multiple sclerosis treatment: First oral drug, new antibody therapies. | JAAPA : official journal of the American Academy of Physician Assistants 20110801 |
| [The study on protective effect of sphingosine-1-phosphate in cardiomyocytes]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110801 |
| Redirected tumor-specific allogeneic T cells for universal treatment of cancer. | Blood 20110728 |
| Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | Life sciences 20110718 |
| Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival. | Transplantation 20110715 |
| Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. | Neuroscience letters 20110715 |
| Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. | The Journal of biological chemistry 20110715 |
| Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS. | Nature reviews. Neurology 20110712 |
| Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | Biochemical and biophysical research communications 20110708 |
| Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | Biomedical chromatography : BMC 20110701 |
| FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. | The European respiratory journal 20110701 |
| S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. | Rheumatology international 20110701 |
| Dissecting the role of the S1P/S1PR axis in health and disease. | Journal of dental research 20110701 |
| Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. | British journal of pharmacology 20110701 |
| CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells. | The Journal of investigative dermatology 20110701 |
| Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701 |
| FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. | Autophagy 20110701 |
| A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. | American journal of physiology. Renal physiology 20110701 |
| Role of sphingosine-1-phosphate in the renal medulla. | American journal of physiology. Renal physiology 20110701 |
| High 1,3-trans stereoselectivity in nucleophilic substitution at the anomeric position and β-fragmentation of the primary alkoxyl radical in 3-amino-3-deoxy-ribofuranose derivatives: application to the synthesis of 2-epi-(-)-jaspine B. | The Journal of organic chemistry 20110701 |
| A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels. | Cell calcium 20110701 |
| Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients. | Journal of immunology (Baltimore, Md. : 1950) 20110701 |
| Discovery of S1P agonists with a dihydronaphthalene scaffold. | Bioorganic & medicinal chemistry letters 20110701 |
| Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. | Journal of cell science 20110701 |
| [Pharmacological targets in multiple sclerosis]. | Revista de neurologia 20110701 |
| Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. | The Journal of surgical research 20110615 |
| Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization. | Biochemical and biophysical research communications 20110610 |
| Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. | Blood 20110602 |
| Exogenous gangliosides increase the release of brain-derived neurotrophic factor. | Neuropharmacology 20110601 |
| Cloning and characterization of a wheat neutral ceramidase gene Ta-CDase. | Molecular biology reports 20110601 |
| Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | Journal of hepatology 20110601 |
| Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis. | Scandinavian journal of immunology 20110601 |
| Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. | Hepatology (Baltimore, Md.) 20110601 |
| Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. | The Journal of pharmacology and experimental therapeutics 20110601 |
| Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways. | American journal of physiology. Lung cellular and molecular physiology 20110601 |
| The outs and the ins of sphingosine-1-phosphate in immunity. | Nature reviews. Immunology 20110601 |
| New drugs 2011 part 2. | Nursing 20110601 |
| Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. | The Journal of clinical investigation 20110601 |
| Transforming multiple sclerosis trials into practical reality. | The Lancet. Neurology 20110601 |
| Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study. | The Lancet. Neurology 20110601 |
| Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants. | Pediatric transplantation 20110601 |
| Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. | Human mutation 20110601 |
| Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis. | Electrophoresis 20110601 |
| [Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia]. | Zhongguo shi yan xue ye xue za zhi 20110601 |
| [Cardiovascular function of sphingosine 1-phosphate signaling]. | Seikagaku. The Journal of Japanese Biochemical Society 20110601 |
| The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. | Molecules and cells 20110531 |
| FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. | The Journal of biological chemistry 20110527 |
| Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. | Journal of medicinal chemistry 20110526 |
| HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. | The Prostate 20110515 |
| Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. | The Journal of biological chemistry 20110506 |
| BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504 |
| Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. | Digestive diseases and sciences 20110501 |
| Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. | Cellular and molecular life sciences : CMLS 20110501 |
| Magnetic resonance imaging as surrogate for clinical endpoints in multiple sclerosis: data on novel oral drugs. | Multiple sclerosis (Houndmills, Basingstoke, England) 20110501 |
| Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501 |
| S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. | American journal of physiology. Cell physiology 20110501 |
| Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. | Kidney international 20110501 |
| Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages. | Microbiology (Reading, England) 20110501 |
| Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. | Biochimica et biophysica acta 20110501 |
| S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. | American journal of physiology. Heart and circulatory physiology 20110501 |
| Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | Analytical and bioanalytical chemistry 20110501 |
| Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. | Journal of immunology (Baltimore, Md. : 1950) 20110501 |
| Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts. | Endocrinology 20110501 |
| The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. | Molecular immunology 20110501 |
| Managing MS in a changing treatment landscape. | Journal of neurology 20110501 |
| Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells. | Plant signaling & behavior 20110501 |
| Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. | Annals of neurology 20110501 |
| Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. | Future medicinal chemistry 20110501 |
| [Genetic dissection of cardiac morphogenesis in zebrafish]. | Seikagaku. The Journal of Japanese Biochemical Society 20110501 |
| Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. | Biochemical and biophysical research communications 20110429 |
| Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. | Journal of natural products 20110425 |
| Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720. | The Journal of biological chemistry 20110422 |
| A rapid assay for assessment of sphingosine kinase inhibitors and substrates. | Analytical biochemistry 20110415 |
| A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20110415 |
| Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. | Biochemical pharmacology 20110415 |
| Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. | The Journal of biological chemistry 20110415 |
| Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. | Neurology 20110405 |
| Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer. | Investigational new drugs 20110401 |
| Sphingosine kinase and sphingosine 1-phosphate in asthma. | Bioscience reports 20110401 |
| Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. | British journal of pharmacology 20110401 |
| G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. | Arteriosclerosis, thrombosis, and vascular biology 20110401 |
| Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. | Journal of thrombosis and haemostasis : JTH 20110401 |
| Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. | Biochimica et biophysica acta 20110401 |
| S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. | American journal of physiology. Cell physiology 20110401 |
| Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. | Journal of cellular biochemistry 20110401 |
| Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. | Glia 20110401 |
| Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. | Experimental dermatology 20110401 |
| Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. | Journal of immunology (Baltimore, Md. : 1950) 20110401 |
| Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. | Hypertension (Dallas, Tex. : 1979) 20110401 |
| Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis. | Advances in therapy 20110401 |
| Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer. | Molecular cancer therapeutics 20110401 |
| Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis. | The American journal of pathology 20110401 |
| [An active lipid signaling molecule: sphingosine-1-phosphate and its biological characteristics]. | Sheng li ke xue jin zhan [Progress in physiology] 20110401 |
| Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling. | Molecular and cellular endocrinology 20110330 |
| Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via η3-allylpalladium intermediates. | Organic & biomolecular chemistry 20110321 |
| Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. | Archives of biochemistry and biophysics 20110315 |
| Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. | Journal of immunology (Baltimore, Md. : 1950) 20110315 |
| In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates. | Fertility and sterility 20110315 |
| Primary varicella zoster infection associated with fingolimod treatment. | Neurology 20110315 |
| Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter. | Cancer research 20110315 |
| Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. | The Journal of biological chemistry 20110304 |
| Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. | Autoimmunity 20110301 |
| Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. | Tissue engineering. Part A 20110301 |
| Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. | Cell death and differentiation 20110301 |
| Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis. | International immunopharmacology 20110301 |
| Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. | Biology of reproduction 20110301 |
| Circulating sphingolipid biomarkers in models of type 1 diabetes. | Journal of lipid research 20110301 |
| Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. | British journal of pharmacology 20110301 |
| Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. | The journal of sexual medicine 20110301 |
| Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. | Biochemical pharmacology 20110301 |
| The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue. | Experimental dermatology 20110301 |
| Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. | Biochimica et biophysica acta 20110301 |
| Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity. | Lipids 20110301 |
| Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of H₂O₂ production. | Molecular plant 20110301 |
| Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. | Pain 20110301 |
| Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. | Cancer biology & therapy 20110301 |
| Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110301 |
| Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety. | Bioorganic & medicinal chemistry letters 20110301 |
| [Encounter of cancer cells with bone. In vivo imaging of osteoclasts and their precursors in intact bone tissues]. | Clinical calcium 20110301 |
| The role of reactive oxygen species and autophagy in safingol-induced cell death. | Cell death & disease 20110301 |
| [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110301 |
| Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. | The Journal of pharmacy and pharmacology 20110301 |
| Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with 'off-the-shelf' third-party regulatory T cells. | Transplantation 20110227 |
| Impact of sphingosine 1-phosphate modulation on immune outcomes. | Neurology 20110222 |
| Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. | Neurology 20110222 |
| Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy. | Neurology 20110222 |
| Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. | Neurology 20110222 |
| The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. | Neurology 20110222 |
| Modulation of sphingosine 1-phosphate signaling in neurologic disease. | Neurology 20110222 |
| [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells]. | Zhonghua yi xue za zhi 20110215 |
| Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. | Circulation research 20110204 |
| Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. | Cell death and differentiation 20110201 |
| [Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system]. | Der Nervenarzt 20110201 |
| Emerging disease-modifying oral therapies for multiple sclerosis. | Journal of neuroimmunology 20110201 |
| Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation. | Autoimmunity reviews 20110201 |
| Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201 |
| Roles for lysophospholipid S1P receptors in multiple sclerosis. | Critical reviews in biochemistry and molecular biology 20110201 |
| Absorption and disposition of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in healthy volunteers: a case of xenobiotic biotransformation following endogenous metabolic pathways. | Drug metabolism and disposition: the biological fate of chemicals 20110201 |
| CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. | Drug metabolism and disposition: the biological fate of chemicals 20110201 |
| Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling. | Cytokine & growth factor reviews 20110201 |
| Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. | Neurochemical research 20110201 |
| Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages. | Archives of biochemistry and biophysics 20110201 |
| Fingolimod for the treatment of relapsing multiple sclerosis. | Expert review of neurotherapeutics 20110201 |
| Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function. | Transplant international : official journal of the European Society for Organ Transplantation 20110201 |
| The ceramide-enriched trans-Golgi compartments reorganize together with other parts of the Golgi apparatus in response to ATP-depletion. | Histochemistry and cell biology 20110201 |
| Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | Nephrology (Carlton, Vic.) 20110201 |
| High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry. | Journal of biomolecular screening 20110201 |
| Multiple sclerosis in 2010: Advances in monitoring and treatment of multiple sclerosis. | Nature reviews. Neurology 20110201 |
| S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. | Cell death & disease 20110201 |
| Identification and evaluation of neutral sphingomyelinase 2 inhibitors. | Archives of pharmacal research 20110201 |
| Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients. | Annals of neurology 20110201 |
| [Current treatment of multiple sclerosis]. | Lege artis medicinae : uj magyar orvosi hirmondo 20110201 |
| The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. | The Journal of biological chemistry 20110121 |
| Regioselective inversion of the hydroxyl group in D-ribo-phytosphingosine via a cyclic sulfate and bis-sulfonate intermediate. | The Journal of organic chemistry 20110121 |
| Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants. | Biochemical and biophysical research communications 20110107 |
| Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101 |
| Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype). | Protist 20110101 |
| CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101 |
| Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. | Biochimie 20110101 |
| Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. | Analytical biochemistry 20110101 |
| Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. | The Journal of investigative dermatology 20110101 |
| Differential responses of human microglia and blood-derived myeloid cells to FTY720. | Journal of neuroimmunology 20110101 |
| Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis. | American journal of physiology. Cell physiology 20110101 |
| Sphingosine kinase localization in the control of sphingolipid metabolism. | Advances in enzyme regulation 20110101 |
| Lipid component quantitation by thin layer chromatography. | Methods in molecular biology (Clifton, N.J.) 20110101 |
| Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved. | CNS drugs 20110101 |
| Sphingosine-1-phosphate and immune regulation: trafficking and beyond. | Trends in pharmacological sciences 20110101 |
| Dose-dependent effect of sphingosine-1-phosphate in mouse oocyte maturation medium on subsequent embryo development. | Gynecologic and obstetric investigation 20110101 |
| Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. | Microcirculation (New York, N.Y. : 1994) 20110101 |
| Therapeutic approach to multiple sclerosis by novel oral drug. | Recent patents on inflammation & allergy drug discovery 20110101 |
| Investigation of the molecular structure of the human stratum corneum ceramides [NP] and [EOS] by mass spectrometry. | Skin pharmacology and physiology 20110101 |
| New drugs: dabigatran etexilate mesylate, fingolimod hydrochloride, and ulipristal acetate. | Journal of the American Pharmacists Association : JAPhA 20110101 |
| A matter of fat: interaction between nitric oxide and sphingolipid signaling in plant cold response. | Plant signaling & behavior 20110101 |
| Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls. | Current topics in medicinal chemistry 20110101 |
| Fingolimod provides long-term protection in rodent models of cerebral ischemia. | Annals of neurology 20110101 |
| Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | PloS one 20110101 |
| Potential of D-erythro-C14-Sphingosine as an adjuvant for a fungal pesticide of Nomuraea rileyi. | Bioscience, biotechnology, and biochemistry 20110101 |
| Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain. | PloS one 20110101 |
| [Immunosuppressive agents in kidney transplantation]. | Nihon Jinzo Gakkai shi 20110101 |
| Current disease-modifying treatment of multiple sclerosis. | The Mount Sinai journal of medicine, New York 20110101 |
| Multiple sclerosis therapeutic pipeline: opportunities and challenges. | The Mount Sinai journal of medicine, New York 20110101 |
| Chemotherapy-induced late transgenerational effects in mice. | PloS one 20110101 |
| Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells. | Nutrition and cancer 20110101 |
| The effect of amino acids on the C₁₄-sphingosine-triggered germination of Nomuraea rileyi, and surface amino acids on Spodoptera litura fabricius. | Bioscience, biotechnology, and biochemistry 20110101 |
| S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | Lipids in health and disease 20110101 |
| S1P is associated with protection in human and experimental cerebral malaria. | Molecular medicine (Cambridge, Mass.) 20110101 |
| Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. | PloS one 20110101 |
| Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells. | Methods in molecular biology (Clifton, N.J.) 20110101 |
| Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. | BMC genetics 20110101 |
| Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice. | Pharmacological reports : PR 20110101 |
| Inverse relationship between adipocyte differentiation and ceramide level in 3T3-L1 cells. | Biological & pharmaceutical bulletin 20110101 |
| Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (Fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen. | Biological & pharmaceutical bulletin 20110101 |
| Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. | PloS one 20110101 |
| Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. | Journal of biomedical science 20110101 |
| The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. | BMC developmental biology 20110101 |
| Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay. | PloS one 20110101 |
| Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells. | International journal of molecular sciences 20110101 |
| Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. | PloS one 20110101 |
| FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia. | PloS one 20110101 |
| Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection. | Cellular immunology 20110101 |
| An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. | Advances in experimental medicine and biology 20110101 |
| FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice. | Acta neurochirurgica. Supplement 20110101 |
| Fingolimod modulates microglial activation to augment markers of remyelination. | Journal of neuroinflammation 20110101 |
| CREST--a large and diverse superfamily of putative transmembrane hydrolases. | Biology direct 20110101 |
| Fingolimod. | Prescrire international 20110101 |
| Cost-effectiveness of natalizumab versus fingolimod for the treatment of relapsing multiple sclerosis. | Journal of medical economics 20110101 |
| Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. | PloS one 20110101 |
| Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation. | Bioscience, biotechnology, and biochemistry 20110101 |
| A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. | PloS one 20110101 |
| Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. | Journal of biomedical science 20110101 |
| Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. | Lipids in health and disease 20110101 |
| Novel therapeutic approaches to autoimmune demyelinating disorders. | Current pharmaceutical design 20110101 |
| Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes. | Reproduction, fertility, and development 20110101 |
| Heart sphingolipids in health and disease. | Advances in experimental medicine and biology 20110101 |
| Blood sphingolipids in homeostasis and pathobiology. | Advances in experimental medicine and biology 20110101 |
| [A plan for risk management in the treatment of multiple sclerosis with gilenia (fingolimod)]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | BMC cancer 20110101 |
| Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. | PloS one 20110101 |
| Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. | PloS one 20110101 |
| The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage. | BMC musculoskeletal disorders 20110101 |
| LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. | PloS one 20110101 |
| Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | Neuroscience 20101229 |
| Oral fingolimod (gilenya) for multiple sclerosis. | The Medical letter on drugs and therapeutics 20101229 |
| Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. | The Journal of biological chemistry 20101224 |
| Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. | American journal of respiratory cell and molecular biology 20101201 |
| Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats. | Immunopharmacology and immunotoxicology 20101201 |
| Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival. | Transplant international : official journal of the European Society for Organ Transplantation 20101201 |
| Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. | Investigative ophthalmology & visual science 20101201 |
| Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. | Cellular and molecular life sciences : CMLS 20101201 |
| Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. | Neurotoxicology 20101201 |
| Global analysis of circulating metabolites in hibernating ground squirrels. | Comparative biochemistry and physiology. Part D, Genomics & proteomics 20101201 |
| p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201 |
| Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. | American journal of physiology. Cell physiology 20101201 |
| Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF). | Cardiovascular drugs and therapy 20101201 |
| Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₁ and S1P₃ and Smad-signalling. | Cytoskeleton (Hoboken, N.J.) 20101201 |
| Identification of specific inhibitors for a trypanosomatid RNA editing reaction. | RNA (New York, N.Y.) 20101201 |
| Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide. | Journal of immunology (Baltimore, Md. : 1950) 20101201 |
| Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. | Cytokine & growth factor reviews 20101201 |
| Dental pulp stem cell migration. | Journal of endodontics 20101201 |
| T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. | Nature medicine 20101201 |
| Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. | Cancer research 20101201 |
| Understanding the effects of FTY720 on leukocyte trafficking. | Archives of neurology 20101201 |
| Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis. | Archives of neurology 20101201 |
| Effect of FTY720 treatment on postischemic pancreatic microhemodynamics. | Transplantation proceedings 20101201 |
| FDA approves the first oral drug for reducing multiple sclerosis relapses. | Harvard women's health watch 20101201 |
| Penasins A-E, long-chain cytotoxic sphingoid bases, from a marine sponge Penares sp. | Journal of natural products 20101129 |
| A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation. | Organic & biomolecular chemistry 20101121 |
| Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101117 |
| The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | Neuroscience letters 20101112 |
| Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1. | The Journal of biological chemistry 20101112 |
| Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. | The Journal of biological chemistry 20101112 |
| Importance of the sphingosine base double-bond geometry for the structural and thermodynamic properties of sphingomyelin bilayers. | Biophysical journal 20101103 |
| SHEP1 partners with CasL to promote marginal zone B-cell maturation. | Proceedings of the National Academy of Sciences of the United States of America 20101102 |
| Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. | Archives of dermatological research 20101101 |
| Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | Journal of bone and mineral metabolism 20101101 |
| Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer. | Breast cancer research and treatment 20101101 |
| Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | Cardiovascular research 20101101 |
| Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | Journal of cellular physiology 20101101 |
| The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | Prostaglandins & other lipid mediators 20101101 |
| Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. | Cellular signalling 20101101 |
| Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. | Basic research in cardiology 20101101 |
| Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. | American journal of physiology. Heart and circulatory physiology 20101101 |
| Selective deuterium labeling of the sphingoid backbone: facile syntheses of 3,4,5-trideuterio-d-erythro-sphingosine and 3-deuterio-d-erythro-sphingomyelin. | Chemistry and physics of lipids 20101101 |
| The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. | Journal of neurophysiology 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver. | Prostaglandins & other lipid mediators 20101101 |
| The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. | Nature immunology 20101101 |
| High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. | The American journal of pathology 20101101 |
| Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. | Stroke 20101101 |
| FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | Autophagy 20101101 |
| Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | Basic research in cardiology 20101101 |
| FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. | Cancer research 20101101 |
| Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. | The Journal of clinical investigation 20101101 |
| Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. | Nature reviews. Drug discovery 20101101 |
| Novartis eyes oral MS drug as potential blockbuster. | Nature biotechnology 20101101 |
| [Role of T lymphocytes in ischemic brain injury]. | Rinsho shinkeigaku = Clinical neurology 20101101 |
| Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | Archives of biochemistry and biophysics 20101015 |
| Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. | The Journal of biological chemistry 20101015 |
| Effect of sphingosine on domain morphology in giant vesicles. | Journal of colloid and interface science 20101015 |
| Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. | Biochemical and biophysical research communications 20101015 |
| Design and synthesis of selective and potent orally active S1P5 agonists. | ChemMedChem 20101004 |
| Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. | Progress in lipid research 20101001 |
| Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | Biomedical chromatography : BMC 20101001 |
| Therapeutic applications of bioactive sphingolipids in hematological malignancies. | International journal of cancer 20101001 |
| Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. | The Journal of investigative dermatology 20101001 |
| Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma. | Pharmacological research 20101001 |
| (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. | Cellular signalling 20101001 |
| FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. | Cellular signalling 20101001 |
| Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients. | Clinical immunology (Orlando, Fla.) 20101001 |
| Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. | Molecular pharmacology 20101001 |
| The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling. | Biopharmaceutics & drug disposition 20101001 |
| Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. | Pflugers Archiv : European journal of physiology 20101001 |
| Sphingosine-1-phosphate signaling in human submandibular cells. | Journal of dental research 20101001 |
| Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells. | European journal of cell biology 20101001 |
| Blood sphingolipidomics in healthy humans: impact of sample collection methodology. | Journal of lipid research 20101001 |
| Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. | Circulation research 20101001 |
| Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. | Biomaterials 20101001 |
| Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts. | European journal of obstetrics, gynecology, and reproductive biology 20101001 |
| Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. | Carcinogenesis 20101001 |
| FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice. | The American journal of pathology 20101001 |
| Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. | The Journal of hand surgery 20101001 |
| Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. | Archives of pharmacal research 20101001 |
| Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. | Future oncology (London, England) 20101001 |
| Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20101001 |
| Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana. | FEBS letters 20100924 |
| Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. | Circulation 20100914 |
| Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. | Life sciences 20100911 |
| Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. | Progress in biophysics and molecular biology 20100901 |
| Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. | Journal of lipid research 20100901 |
| Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. | Molecular and cellular biochemistry 20100901 |
| Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. | Cellular signalling 20100901 |
| Emerging therapies in relapsing-remitting multiple sclerosis. | Reviews on recent clinical trials 20100901 |
| PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. | Journal of cellular biochemistry 20100901 |
| HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. | Journal of lipid research 20100901 |
| The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein. | Biopolymers 20100901 |
| UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | Prostaglandins & other lipid mediators 20100901 |
| A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination. | European journal of immunology 20100901 |
| The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720. | Biomaterials 20100901 |
| Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions. | Glia 20100901 |
| Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. | Arteriosclerosis, thrombosis, and vascular biology 20100901 |
| Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. | Journal of cellular and molecular medicine 20100901 |
| Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | British journal of pharmacology 20100901 |
| Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. | Acta pharmacologica Sinica 20100901 |
| Emerging oral agents for multiple sclerosis. | The American journal of managed care 20100901 |
| Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | The Journal of biological chemistry 20100827 |
| Development of a sphingosylphosphorylcholine detection system using RNA aptamers. | Molecules (Basel, Switzerland) 20100820 |
| Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. | Neuroscience letters 20100816 |
| Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells. | Journal of cellular biochemistry 20100815 |
| Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. | Journal of immunology (Baltimore, Md. : 1950) 20100815 |
| Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. | Structure (London, England : 1993) 20100811 |
| Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H. | The Journal of organic chemistry 20100806 |
| Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis. | Neurology 20100803 |
| FTY720 and central memory: out of sight, out of mind. | Neurology 20100803 |
| Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. | The Journal of experimental medicine 20100802 |
| The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. | BJU international 20100801 |
| TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes. | Journal of neurochemistry 20100801 |
| Effect of combined treatment with FK506, FTY720, and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. | Pediatric transplantation 20100801 |
| Aquilegia vulgaris L. extract counteracts oxidative stress and cytotoxicity of fumonisin in rats. | Toxicon : official journal of the International Society on Toxinology 20100801 |
| Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. | Annals of biomedical engineering 20100801 |
| Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model. | Clinical immunology (Orlando, Fla.) 20100801 |
| Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | Laboratory investigation; a journal of technical methods and pathology 20100801 |
| Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20100801 |
| Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. | Endocrinology 20100801 |
| N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. | Apoptosis : an international journal on programmed cell death 20100801 |
| Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells. | Journal of molecular cell biology 20100801 |
| Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China. | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100801 |
| FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis. | Transplant immunology 20100801 |
| Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. | The FEBS journal 20100801 |
| Update on emerging therapies for multiple sclerosis. | Expert review of neurotherapeutics 20100801 |
| A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis. | Discovery medicine 20100801 |
| Avoiding infusion therapy prime benefit of new MS drug. | Managed care (Langhorne, Pa.) 20100801 |
| A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. | The Journal of biological chemistry 20100723 |
| Flexible and enantioselective access to jaspine B and biologically active chain-modified analogues thereof. | Organic & biomolecular chemistry 20100721 |
| CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. | The Journal of biological chemistry 20100716 |
| Runx regulation of sphingolipid metabolism and survival signaling. | Cancer research 20100715 |
| Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde. | The Journal of organic chemistry 20100702 |
| L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation. | The Journal of nutritional biochemistry 20100701 |
| Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. | American journal of respiratory cell and molecular biology 20100701 |
| Quantitative sphingosine measurement as a surrogate for total ceramide concentration-preclinical and potential translational applications. | Biomedical chromatography : BMC 20100701 |
| Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. | Microvascular research 20100701 |
| Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100701 |
| Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. | Biochemical pharmacology 20100701 |
| Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. | Arthritis and rheumatism 20100701 |
| Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20100701 |
| S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. | American journal of physiology. Lung cellular and molecular physiology 20100701 |
| Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. | Journal of neurochemistry 20100701 |
| S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. | Endocrinology 20100701 |
| Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. | Stroke 20100701 |
| Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. | Cancer research 20100701 |
| Fingolimod is a potential novel therapy for multiple sclerosis. | Nature reviews. Neurology 20100701 |
| Printing a tissue: a new engineering strategy for cardiovascular regeneration. | Arteriosclerosis, thrombosis, and vascular biology 20100701 |
| Sphingosine 1-phosphate and cancer. | Nature reviews. Cancer 20100701 |
| An update on sphingosine-1-phosphate and other sphingolipid mediators. | Nature chemical biology 20100701 |
| Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice. | Lipids 20100701 |
| Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion. | British journal of pharmacology 20100701 |
| S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. | Current opinion in drug discovery & development 20100701 |
| Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors. | Bioorganic & medicinal chemistry letters 20100701 |
| Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. | Anticancer research 20100701 |
| The effect of a phytosphingosine-like substance isolated from Asterina pectinifera on involucrin expression in mite antigen-stimulated HaCaT cells. | Natural product communications 20100701 |
| [Fingolimod in the treatment of multiple sclerosis. Novelties presented at the annual congress of the American Academy of Neurology (Toronto, April 2010)]. | Drugs of today (Barcelona, Spain : 1998) 20100701 |
| [Lysophospholipids]. | Nihon rinsho. Japanese journal of clinical medicine 20100701 |
| Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions. | International journal of pharmaceutics 20100630 |
| Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. | Neuroscience letters 20100625 |
| Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. | Nature 20100624 |
| FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100615 |
| Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis. | Neurology 20100615 |
| Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. | Circulation research 20100611 |
| Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B). | The Journal of organic chemistry 20100604 |
| Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of propargyl chlorides and carbonates. | The Journal of organic chemistry 20100604 |
| [Emerging treatments for multiple sclerosis]. | Revue medicale suisse 20100602 |
| FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. | Tissue engineering. Part A 20100601 |
| Anaphylaxis: an update on its understanding and management. | Recent patents on inflammation & allergy drug discovery 20100601 |
| Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: structural characterization and immunoreactivity in cerebrospinal fluid. | Journal of lipid research 20100601 |
| S1P metabolism in cancer and other pathological conditions. | Biochimie 20100601 |
| Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. | Journal of cardiovascular pharmacology and therapeutics 20100601 |
| Hemolysis induced by Bacillus cereus sphingomyelinase. | Biochimica et biophysica acta 20100601 |
| Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. | Diabetes 20100601 |
| Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting. | Current molecular pharmacology 20100601 |
| Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. | Journal of the American Society of Nephrology : JASN 20100601 |
| The impact of fingolimod (FTY720) in neuroimmunologic diseases: mechanisms beyond immunomodulation. | The American journal of pathology 20100601 |
| Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. | The American journal of pathology 20100601 |
| The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | The Journal of clinical investigation 20100601 |
| Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. | International immunology 20100601 |
| [Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery]. | Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20100601 |
| Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526 |
| Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. | European journal of pharmacology 20100525 |
| Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis. | The Journal of biological chemistry 20100521 |
| A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. | The Journal of biological chemistry 20100521 |
| Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets. | Chemico-biological interactions 20100514 |
| Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. | The Journal of biological chemistry 20100507 |
| Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. | Biochemical and biophysical research communications 20100507 |
| Oral cladribine and fingolimod for relapsing multiple sclerosis. | The New England journal of medicine 20100506 |
| Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. | Clinica chimica acta; international journal of clinical chemistry 20100502 |
| Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. | American journal of respiratory cell and molecular biology 20100501 |
| Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival. | Journal of lipid research 20100501 |
| Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720. | Transplant international : official journal of the European Society for Organ Transplantation 20100501 |
| Evaluation of experimental autoimmune uveitis in mice treated with FTY720. | Investigative ophthalmology & visual science 20100501 |
| Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats. | Acta physiologica (Oxford, England) 20100501 |
| The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep. | Biology of reproduction 20100501 |
| Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity. | Cellular and molecular life sciences : CMLS 20100501 |
| Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. | Xenobiotica; the fate of foreign compounds in biological systems 20100501 |
| Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins. | Current pharmaceutical design 20100501 |
| Inhibition of sodium-calcium exchange by KB-R7943: Dodecylamine and sphingosine in transfected Chinese hamster ovary cells. | Cell calcium 20100501 |
| Mammalian ceramide synthases. | IUBMB life 20100501 |
| Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. | Stem cells (Dayton, Ohio) 20100501 |
| Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. | Leukemia 20100501 |
| Fingolimod for relapsing multiple sclerosis: an update. | Expert opinion on pharmacotherapy 20100501 |
| Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. | Kidney international 20100501 |
| Pecipamide, a new sphingosine derivative from the cultures of Polyporus picipes (Basidiomycetes). | Lipids 20100501 |
| The riddle of the sphinx redux. | Kidney international 20100501 |
| Identification of glucosylceramides containing sphingatrienine in maize and rice using ion trap mass spectrometry. | Lipids 20100501 |
| Oral fingolimod for the treatment of relapsing-remitting multiple sclerosis. | Drugs of today (Barcelona, Spain : 1998) 20100501 |
| [Updates on clinicopathologic findings of Niemann-Pick disease type C]. | Zhonghua bing li xue za zhi = Chinese journal of pathology 20100501 |
| Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. | Blood 20100429 |
| Effect of S1P5 on proliferation and migration of human esophageal cancer cells. | World journal of gastroenterology 20100421 |
| Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. | Journal of cellular biochemistry 20100415 |
| A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. | Rapid communications in mass spectrometry : RCM 20100415 |
| Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia. | Journal of immunology (Baltimore, Md. : 1950) 20100415 |
| FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice. | Biochemical and biophysical research communications 20100409 |
| Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. | Journal of medicinal chemistry 20100408 |
| Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. | The Journal of biological chemistry 20100402 |
| Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. | The Journal of biological chemistry 20100402 |
| Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | The Journal of nutritional biochemistry 20100401 |
| Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. | Immunobiology 20100401 |
| Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis. | Prostaglandins & other lipid mediators 20100401 |
| Photoactivable sphingosine as a tool to study membrane microenvironments in cultured cells. | Journal of lipid research 20100401 |
| FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. | Cancer immunology, immunotherapy : CII 20100401 |
| Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. | Shock (Augusta, Ga.) 20100401 |
| Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase. | Cellular signalling 20100401 |
| Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin. | Journal of lipid research 20100401 |
| Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes. | Cardiovascular research 20100401 |
| Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease. | Traffic (Copenhagen, Denmark) 20100401 |
| Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. | Steroids 20100401 |
| The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome. | European journal of clinical nutrition 20100401 |
| Targeting the sphingolipid signaling pathway in stroke. | Stroke 20100401 |
| Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. | Developmental dynamics : an official publication of the American Association of Anatomists 20100401 |
| Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. | Stem cells (Dayton, Ohio) 20100401 |
| Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. | American journal of nephrology 20100401 |
| [How rare is tuberculosis?]. | Medizinische Monatsschrift fur Pharmazeuten 20100401 |
| [Development of oral therapies for multiple sclerosis--fingolimod, cladribine and other drugs]. | Medizinische Monatsschrift fur Pharmazeuten 20100401 |
| C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts. | Biomedical research (Tokyo, Japan) 20100401 |
| Multiple sclerosis: closing in on an oral treatment. | Nature 20100318 |
| Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine. | Bioorganic & medicinal chemistry letters 20100315 |
| Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. | Neuroscience 20100310 |
| FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | Circulation research 20100305 |
| [Progress of therapy in patients with multiple sclerosis]. | MMW Fortschritte der Medizin 20100304 |
| Deregulation of sphingolipid metabolism in Alzheimer's disease. | Neurobiology of aging 20100301 |
| Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I. | Journal of cellular and molecular medicine 20100301 |
| Normalization of diabetic wound healing. | Surgery 20100301 |
| Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. | Cellular signalling 20100301 |
| United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100301 |
| Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy. | Biology of reproduction 20100301 |
| Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. | American journal of physiology. Cell physiology 20100301 |
| High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. | American journal of physiology. Heart and circulatory physiology 20100301 |
| Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation. | Reproductive biomedicine online 20100301 |
| miR-181a and miR-630 regulate cisplatin-induced cancer cell death. | Cancer research 20100301 |
| Discovery of a novel series of potent S1P1 agonists. | Bioorganic & medicinal chemistry letters 20100301 |
| S1P receptor mediated activity of FTY720 phosphate mimics. | Bioorganic & medicinal chemistry letters 20100301 |
| New drugs may improve, complicate treatment for multiple sclerosis. | Nature medicine 20100301 |
| Cell phenotype evaluation at various sites after skin transplantation and FTY720 plus sirolimus therapy. | Transplantation proceedings 20100301 |
| Leishmania (Leishmania) amazonensis infection in mice treated with FTY720. | Transplantation proceedings 20100301 |
| Sirolimus in combination with FTY720: analysis of urinary and serum parameters. | Transplantation proceedings 20100301 |
| Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants. | Transplantation 20100227 |
| Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition. | The Journal of biological chemistry 20100226 |
| Influence of a phytosphingosine-containing chlorhexidine shampoo on superficial bacterial counts and bacterial adherence to canine keratinocytes. | Veterinary microbiology 20100224 |
| Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. | Virology 20100220 |
| Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. | American journal of respiratory and critical care medicine 20100215 |
| Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia. | Neuroscience letters 20100212 |
| A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. | The New England journal of medicine 20100204 |
| Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. | The New England journal of medicine 20100204 |
| Oral therapy for multiple sclerosis--sea change or incremental step? | The New England journal of medicine 20100204 |
| FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. | Journal of neuroscience research 20100201 |
| Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. | Investigative ophthalmology & visual science 20100201 |
| Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. | Pulmonary pharmacology & therapeutics 20100201 |
| FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. | Journal of molecular and cellular cardiology 20100201 |
| Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. | Stroke 20100201 |
| The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | British journal of pharmacology 20100201 |
| Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. | Multiple sclerosis (Houndmills, Basingstoke, England) 20100201 |
| Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. | FEMS microbiology letters 20100201 |
| ABC transporters in cancer: more than just drug efflux pumps. | Nature reviews. Cancer 20100201 |
| HDL lipids and insulin resistance. | Current diabetes reports 20100201 |
| Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. | The Journal of pharmacy and pharmacology 20100201 |
| Sphingosine-1-phosphate and its receptors as a possible therapeutic target in autoimmune diseases of the nervous system. | Journal of neuroimmunology 20100125 |
| Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. | The Journal of experimental medicine 20100118 |
| Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. | Experimental cell research 20100115 |
| Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. | The Journal of biological chemistry 20100115 |
| Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces. | Physical chemistry chemical physics : PCCP 20100114 |
| New endogenous regulators of class I histone deacetylases. | Science signaling 20100105 |
| Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes. | International journal of pharmaceutics 20100104 |
| Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. | Acta biomaterialia 20100101 |
| Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. | Cardiovascular research 20100101 |
| Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. | Shock (Augusta, Ga.) 20100101 |
| Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease. | European heart journal 20100101 |
| A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. | Gastroenterology 20100101 |
| FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration. | Laboratory investigation; a journal of technical methods and pathology 20100101 |
| Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. | Immunology 20100101 |
| Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice. | Journal of dermatological science 20100101 |
| Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. | Advances in enzyme regulation 20100101 |
| Phytosphingosine kills Candida albicans by disrupting its cell membrane. | Biological chemistry 20100101 |
| Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. | Biochemical and biophysical research communications 20100101 |
| Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60. | Leukemia & lymphoma 20100101 |
| A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. | Glycobiology 20100101 |
| Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells. | Cell calcium 20100101 |
| Enantioselective syntheses of pachastrissamine and jaspine A via hydroxylactonization of a chiral epoxy ester. | Bioscience, biotechnology, and biochemistry 20100101 |
| Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. | Clinical neuropharmacology 20100101 |
| Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. | Molecules and cells 20100101 |
| [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation]. | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20100101 |
| Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis. | Bioscience, biotechnology, and biochemistry 20100101 |
| Revealing a signaling role of phytosphingosine-1-phosphate in yeast. | Molecular systems biology 20100101 |
| A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. | PloS one 20100101 |
| Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints. | Arthritis research & therapy 20100101 |
| Synthesis and structure-activity relationships of skin ceramides. | Current medicinal chemistry 20100101 |
| Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages. | PloS one 20100101 |
| Spingolipids in Multiple Sclerosis. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Endothelial functions of sphingosine-1-phosphate. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. | BMC musculoskeletal disorders 20100101 |
| Characterization of a germination-accelerating factor from the silkworm (Bombyx mori Linnaeus) of entomopathogenic fungus Nomuraea rileyi (Farlow) Samson. | Bioscience, biotechnology, and biochemistry 20100101 |
| Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. | PloS one 20100101 |
| Arthritis: where are the T cells? | Arthritis research & therapy 20100101 |
| An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival. | BMC cell biology 20100101 |
| Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine. | Drug design, development and therapy 20100101 |
| Deoxysphingoid bases as plasma markers in diabetes mellitus. | Lipids in health and disease 20100101 |
| A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate. | Biological & pharmaceutical bulletin 20100101 |
| Multiple sclerosis therapies: molecular mechanisms and future. | Results and problems in cell differentiation 20100101 |
| Distribution and metabolism of sphingosine in skin after oral administration to mice. | Drug metabolism and pharmacokinetics 20100101 |
| Extracellular and intracellular actions of sphingosine-1-phosphate. | Advances in experimental medicine and biology 20100101 |
| Cancer treatment strategies targeting sphingolipid metabolism. | Advances in experimental medicine and biology 20100101 |
| SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | Journal of pharmacological sciences 20100101 |
| Altered expression of signaling genes in Jurkat cells upon FTY720 induced apoptosis. | International journal of molecular sciences 20100101 |
| FTY720-induced suicidal erythrocyte death. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| New antinociceptive agents related to dihydrosphingosine. | Pharmacological reports : PR 20100101 |
| Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway. | Journal of pharmacological sciences 20100101 |
| Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. | Mediators of inflammation 20100101 |
| [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. | Biomeditsinskaia khimiia 20100101 |
| Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells. | Journal of agricultural and food chemistry 20091223 |
| Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo. | The Journal of biological chemistry 20091204 |
| Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis. | Fertility and sterility 20091201 |
| Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. | Pathology oncology research : POR 20091201 |
| Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. | Burns : journal of the International Society for Burn Injuries 20091201 |
| FTY720 reduces inflammation and promotes functional recovery after spinal cord injury. | Journal of neurotrauma 20091201 |
| Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat. | Molecular reproduction and development 20091201 |
| Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. | The Journal of investigative dermatology 20091201 |
| Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells. | Journal of biochemistry 20091201 |
| Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. | Experimental eye research 20091201 |
| Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement. | Cellular signalling 20091201 |
| Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. | Journal of neurophysiology 20091201 |
| Lysophospholipids enhance taurine release from rat retinal vascular endothelial cells under hypoosmotic stress. | Microvascular research 20091201 |
| Pharmacologic therapies on the horizon for acute lung injury/acute respiratory distress syndrome. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20091201 |
| Vascular integrity mediated by vascular endothelial cadherin and regulated by sphingosine 1-phosphate and angiopoietin-1. | Circulation journal : official journal of the Japanese Circulation Society 20091201 |
| The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. | International journal of oncology 20091201 |
| Ovarian transplantation for fertility preservation in a sheep model: can follicle loss be prevented by antiapoptotic sphingosine-1-phosphate administration? | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20091201 |
| T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion? | Neurosurgery 20091201 |
| Treatment with immunosuppressants FTY720 and tacrolimus promotes functional recovery after spinal cord injury in rats. | The Tohoku journal of experimental medicine 20091201 |
| Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases. | The Keio journal of medicine 20091201 |
| Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. | Arhiv za higijenu rada i toksikologiju 20091201 |
| Chemotherapy induces ATP release from tumor cells. | Cell cycle (Georgetown, Tex.) 20091115 |
| Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. | Biochemical and biophysical research communications 20091113 |
| Efficient synthesis of D-xylo and D-ribo-phytosphingosines from methyl 2-amino-2-deoxy-beta-D-hexopyranosides. | Carbohydrate research 20091102 |
| Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. | Stem cells and development 20091101 |
| Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability. | Cancer letters 20091101 |
| Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. | Journal of lipid research 20091101 |
| Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism. | Experimental cell research 20091101 |
| Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. | International journal of cancer 20091101 |
| FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. | Cellular signalling 20091101 |
| Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness. | The Journal of allergy and clinical immunology 20091101 |
| Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells. | American journal of physiology. Cell physiology 20091101 |
| Horizontal chromosome transfer, a mechanism for the evolution and differentiation of a plant-pathogenic fungus. | Eukaryotic cell 20091101 |
| Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice. | British journal of pharmacology 20091101 |
| Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells. | Endocrinology 20091101 |
| Discovery of novel sphingosine kinase 1 inhibitors. | Bioorganic & medicinal chemistry letters 20091101 |
| FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. | British journal of pharmacology 20091101 |
| [Multiple sclerosis, the therapeutic arsenal of today and tomorrow]. | Soins; la revue de reference infirmiere 20091101 |
| News & views in ... Immunotherapy. | Immunotherapy 20091101 |
| Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells. | BMB reports 20091031 |
| Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog. | Transplantation 20091027 |
| T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. | The Journal of experimental medicine 20091026 |
| The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. | Proceedings of the National Academy of Sciences of the United States of America 20091020 |
| Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. | Archives of biochemistry and biophysics 20091015 |
| MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro. | Lung cancer (Amsterdam, Netherlands) 20091001 |
| FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. | Neuropathology and applied neurobiology 20091001 |
| Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. | Molecular carcinogenesis 20091001 |
| Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091001 |
| Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells. | The Prostate 20091001 |
| Sphingolipids in inflammation: pathological implications and potential therapeutic targets. | British journal of pharmacology 20091001 |
| Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum. | Journal of biochemistry 20091001 |
| Lipids as targets for novel anti-inflammatory therapies. | Pharmacology & therapeutics 20091001 |
| Sphingosine 1-phosphate: a regulator of arterial lesions. | Arteriosclerosis, thrombosis, and vascular biology 20091001 |
| Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro. | The Journal of pharmacology and experimental therapeutics 20091001 |
| Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. | Arteriosclerosis, thrombosis, and vascular biology 20091001 |
| Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. | Endocrinology 20091001 |
| Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | Naunyn-Schmiedeberg's archives of pharmacology 20091001 |
| Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. | Stroke 20091001 |
| Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. | American journal of physiology. Heart and circulatory physiology 20091001 |
| Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. | Immunology and cell biology 20091001 |
| Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins. | American journal of physiology. Cell physiology 20091001 |
| Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. | Kidney international 20091001 |
| Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. | Cellular and molecular life sciences : CMLS 20091001 |
| Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20091001 |
| Susceptibility of Phelipanche and Orobanche species to AAL-toxin. | Planta 20091001 |
| The future of multiple sclerosis therapy. | Pharmacological research 20091001 |
| Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation. | Journal of biomolecular screening 20091001 |
| Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. | The American journal of pathology 20091001 |
| Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of bromoallenes. | Organic letters 20091001 |
| Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection. | Journal of immunology (Baltimore, Md. : 1950) 20091001 |
| Sphingosine kinase-1: a potential mediator of renal fibrosis. | Kidney international 20091001 |
| [Fingolimod - a new immunomodulator]. | Deutsche medizinische Wochenschrift (1946) 20091001 |
| Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. | The American journal of tropical medicine and hygiene 20091001 |
| Recognition of lyso-phospholipids by human natural killer T lymphocytes. | PLoS biology 20091001 |
| New oral drugs for multiple sclerosis. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20091001 |
| Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy. | Journal of neuroimmunology 20090929 |
| The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. | The Journal of biological chemistry 20090925 |
| Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. | Circulation research 20090925 |
| Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. | Circulation research 20090925 |
| Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. | Journal of medicinal chemistry 20090924 |
| Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. | The Journal of biological chemistry 20090918 |
| High-yielding synthesis of sphingoid-type bases. | The Journal of organic chemistry 20090918 |
| Sphinganine-sphingosine ratio in urine from two Portuguese populations as biomarker to fumonisins exposure. | Toxicon : official journal of the International Society on Toxinology 20090915 |
| The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. | Journal of immunology (Baltimore, Md. : 1950) 20090915 |
| Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. | Analytica chimica acta 20090914 |
| Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. | Science (New York, N.Y.) 20090904 |
| The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta. | Blood 20090903 |
| Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments. | Biophysical journal 20090902 |
| Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors. | Investigative ophthalmology & visual science 20090901 |
| Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. | Journal of lipid research 20090901 |
| The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism. | Biochemical pharmacology 20090901 |
| Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. | Cancer science 20090901 |
| Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. | Diabetes 20090901 |
| Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function. | Microbiology (Reading, England) 20090901 |
| Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. | American journal of physiology. Renal physiology 20090901 |
| Fragile maintenance of allograft tolerance induced by lymphocyte sequestration and co-stimulation blockade. | Transplant immunology 20090901 |
| Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | Journal of neurochemistry 20090901 |
| Effect of dimethyl sulfoxide on the phase behavior of model stratum corneum lipid mixtures. | Chemistry and physics of lipids 20090901 |
| Lipid signaling in Arabidopsis: no sphingosine? No problem! | Trends in plant science 20090901 |
| Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. | Medical science monitor : international medical journal of experimental and clinical research 20090901 |
| Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. | Cancer research 20090901 |
| [Discovery of S1P transporter may uncover the unidentified S1P-regulated signal in circulation, immunity, and bone metabolism]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901 |
| [Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090901 |
| [Sphingolipids in embryonic implantation]. | Ginecologia y obstetricia de Mexico 20090901 |
| N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. | Toxicology and applied pharmacology 20090815 |
| Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions. | Journal of immunology (Baltimore, Md. : 1950) 20090815 |
| Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. | Bioorganic & medicinal chemistry 20090815 |
| Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. | Archives of biochemistry and biophysics 20090815 |
| Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. | The Journal of biological chemistry 20090807 |
| Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. | Journal of lipid research 20090801 |
| Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. | The Journal of investigative dermatology 20090801 |
| Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus. | Genome research 20090801 |
| S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. | American journal of physiology. Cell physiology 20090801 |
| Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. | Microcirculation (New York, N.Y. : 1994) 20090801 |
| Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. | Journal of neurochemistry 20090801 |
| (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts. | International journal of molecular medicine 20090801 |
| Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090801 |
| Langerhans cell migration: not necessarily always at the center of the skin sensitization universe. | The Journal of investigative dermatology 20090801 |
| Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization. | Genes to cells : devoted to molecular & cellular mechanisms 20090801 |
| [Molecular target drug development for curing multiple sclerosis]. | Brain and nerve = Shinkei kenkyu no shinpo 20090801 |
| Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. | Cardiovascular research 20090715 |
| Phase behavior of an equimolar mixture of N-palmitoyl-D-erythro-sphingosine, cholesterol, and palmitic acid, a mixture with optimized hydrophobic matching. | Langmuir : the ACS journal of surfaces and colloids 20090707 |
| Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. | The Journal of biological chemistry 20090703 |
| VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. | Glycoconjugate journal 20090701 |
| Export and functions of sphingosine-1-phosphate. | Biochimica et biophysica acta 20090701 |
| Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression. | Diabetes 20090701 |
| Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. | American journal of physiology. Endocrinology and metabolism 20090701 |
| The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. | American journal of physiology. Renal physiology 20090701 |
| A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. | Journal of dermatological science 20090701 |
| Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186. | The Journal of antibiotics 20090701 |
| Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. | Bioorganic & medicinal chemistry letters 20090701 |
| Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090701 |
| Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | International journal of molecular medicine 20090701 |
| Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | The Journal of clinical investigation 20090701 |
| Regulation of blood and vascular cell function by bioactive lysophospholipids. | Journal of thrombosis and haemostasis : JTH 20090701 |
| Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro. | Clinical and experimental immunology 20090701 |
| Saturated ceramides from the sponge Dysidea robusta. | Natural product communications 20090701 |
| Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. | Journal of medicinal chemistry 20090625 |
| Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. | Bioorganic & medicinal chemistry letters 20090615 |
| Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. | The Journal of biological chemistry 20090612 |
| The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. | Blood 20090611 |
| Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. | Neuron 20090611 |
| FTY720 and lung tumor development. | International immunopharmacology 20090601 |
| Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601 |
| Entamoeba invadens: sphingolipids metabolic regulation is the main component of a PKC signaling pathway in controlling cell growth and proliferation. | Experimental parasitology 20090601 |
| TRPC channel lipid specificity and mechanisms of lipid regulation. | Cell calcium 20090601 |
| High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. | Clinical chemistry 20090601 |
| FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. | Arteriosclerosis, thrombosis, and vascular biology 20090601 |
| Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. | Journal of hepatology 20090601 |
| Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells. | Arteriosclerosis, thrombosis, and vascular biology 20090601 |
| Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. | Nature chemical biology 20090601 |
| Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. | Journal of cardiovascular pharmacology 20090601 |
| [New therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090601 |
| Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720. | Pathology international 20090601 |
| [FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20090601 |
| Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis. | The Journal of biological chemistry 20090515 |
| Design and synthesis of piperidine-containing sphingoid base analogues. | The Journal of organic chemistry 20090515 |
| The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. | Journal of medicinal chemistry 20090514 |
| Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. | The Journal of biological chemistry 20090508 |
| Sphingosine kinase regulation and cardioprotection. | Cardiovascular research 20090501 |
| Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. | Endocrinology 20090501 |
| Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. | Cardiovascular research 20090501 |
| Endothelial-mural cell signaling in vascular development and angiogenesis. | Arteriosclerosis, thrombosis, and vascular biology 20090501 |
| The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. | Cellular signalling 20090501 |
| Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. | Cardiovascular research 20090501 |
| Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. | Cardiovascular research 20090501 |
| Sphingosine-1-phosphate and modulation of vascular tone. | Cardiovascular research 20090501 |
| Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. | Cardiovascular research 20090501 |
| Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. | American journal of physiology. Heart and circulatory physiology 20090501 |
| Regional heterogeneity in expression of the sphingosine-1-phosphate pathway in the female rat lower urinary tract. | American journal of obstetrics and gynecology 20090501 |
| The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. | European journal of pharmacology 20090501 |
| Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis. | European journal of pharmacology 20090501 |
| Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. | The Journal of biological chemistry 20090501 |
| Lipid signalling in cardiovascular pathophysiology. | Cardiovascular research 20090501 |
| Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis. | Journal of vascular surgery 20090501 |
| Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. | Microvascular research 20090501 |
| Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells. | Cellular and molecular life sciences : CMLS 20090501 |
| Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. | The American journal of pathology 20090501 |
| Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation. | Journal of cell science 20090501 |
| Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration. | Genes to cells : devoted to molecular & cellular mechanisms 20090501 |
| When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | Cancer research 20090501 |
| Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. | Anti-cancer agents in medicinal chemistry 20090501 |
| Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells. | Chemistry & biodiversity 20090501 |
| Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides. | Chemistry & biodiversity 20090501 |
| [Role of S1P in the lipoprotein-induced actions and their signaling mechanism]. | Seikagaku. The Journal of Japanese Biochemical Society 20090501 |
| Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation. | Trends in cardiovascular medicine 20090501 |
| Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. | Biochimica et biophysica acta 20090501 |
| Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons. | The Journal of biological chemistry 20090424 |
| S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. | Cancer letters 20090418 |
| Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720. | The Journal of organic chemistry 20090417 |
| Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists. | Bioorganic & medicinal chemistry letters 20090415 |
| pH dependence of sphingosine aggregation. | Biophysical journal 20090408 |
| FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. | Brain pathology (Zurich, Switzerland) 20090401 |
| The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. | The international journal of biochemistry & cell biology 20090401 |
| Immunosuppressive therapy and post-transplant malignancy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090401 |
| Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. | Journal of lipid research 20090401 |
| Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis. | Journal of lipid research 20090401 |
| Lipid phosphate phosphatases and signaling. | Journal of lipid research 20090401 |
| Targeting sphingosine-1-phosphate signalling for cardioprotection. | Current opinion in pharmacology 20090401 |
| Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. | Journal of molecular and cellular cardiology 20090401 |
| Differential regulation of sphingosine kinases 1 and 2 in lung injury. | American journal of physiology. Lung cellular and molecular physiology 20090401 |
| Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques. | The Journal of antimicrobial chemotherapy 20090401 |
| Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond. | European journal of immunology 20090401 |
| Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice. | Cell biology international 20090401 |
| Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090401 |
| Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). | British journal of pharmacology 20090401 |
| Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin. | Thrombosis and haemostasis 20090401 |
| Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. | Journal of pediatric surgery 20090401 |
| Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug. | Molecular cancer therapeutics 20090401 |
| [A new therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)]. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090401 |
| Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. | International journal of pharmaceutics 20090331 |
| Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. | Nature 20090326 |
| Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. | Chembiochem : a European journal of chemical biology 20090323 |
| B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. | Immunity 20090320 |
| Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report. | Neurology 20090317 |
| Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog. | Biochemical pharmacology 20090315 |
| Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells. | European journal of pharmacology 20090315 |
| Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. | Biochemical and biophysical research communications 20090306 |
| Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. | Digestive diseases and sciences 20090301 |
| Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. | Biology of the cell 20090301 |
| Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization. | Experimental eye research 20090301 |
| Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. | Journal of lipid research 20090301 |
| BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization. | Neuropharmacology 20090301 |
| Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. | American journal of physiology. Renal physiology 20090301 |
| Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy. | The Journal of pharmacology and experimental therapeutics 20090301 |
| Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats. | Experimental neurology 20090301 |
| Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. | Molecular therapy : the journal of the American Society of Gene Therapy 20090301 |
| Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20090301 |
| The jasmonate signaling pathway in tomato regulates susceptibility to a toxin-dependent necrotrophic pathogen. | Planta 20090301 |
| Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. | Apoptosis : an international journal on programmed cell death 20090301 |
| Effect of Asparagus racemosus extract on transdermal delivery of carvedilol: a mechanistic study. | AAPS PharmSciTech 20090301 |
| Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. | Molecular cancer research : MCR 20090301 |
| Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. | Journal of cardiovascular pharmacology 20090301 |
| Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine. | Molecular cancer research : MCR 20090301 |
| Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship. | Journal of pharmacological sciences 20090301 |
| [Advances in thrombin-protease-activated receptor 1-sphingosine 1-phosphate pathway during sepsis]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090301 |
| Sphingosine-1 phosphate: a new player in osteoimmunology. | Developmental cell 20090301 |
| FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells. | Transplantation proceedings 20090301 |
| Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. | The Journal of biological chemistry 20090227 |
| FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. | The Journal of biological chemistry 20090227 |
| Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. | Oncogene 20090226 |
| Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. | The Journal of biological chemistry 20090220 |
| Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. | Journal of cell science 20090215 |
| Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. | Journal of cell science 20090215 |
| Cell biology. The ABCs of lipophile transport. | Science (New York, N.Y.) 20090213 |
| Identification of tight junction modulating lipids. | Journal of pharmaceutical sciences 20090201 |
| Role for sphingosine kinase 1 in colon carcinogenesis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090201 |
| Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. | Journal of cellular physiology 20090201 |
| Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. | Histochemistry and cell biology 20090201 |
| Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090201 |
| Ceramide production associated with retinal apoptosis after retinal detachment. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090201 |
| Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. | Cellular signalling 20090201 |
| Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. | American journal of physiology. Cell physiology 20090201 |
| N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. | Bioorganic & medicinal chemistry letters 20090201 |
| Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. | Autophagy 20090201 |
| Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. | Journal of clinical pharmacology 20090201 |
| Trial watch: Phase III promise for oral multiple sclerosis therapy. | Nature reviews. Drug discovery 20090201 |
| [Sphingolipids and their medical impact]. | Deutsche medizinische Wochenschrift (1946) 20090201 |
| [An additional role of FTY720 in chronic colitis]. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090201 |
| Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. | Biomedical and environmental sciences : BES 20090201 |
| [The effects of Sphing-1-phosphate(S1P) on the potassium channel of the ventricular myocytes]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090201 |
| The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. | Science (New York, N.Y.) 20090123 |
| Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. | Neurology 20090106 |
| Endothelial cell migration in human plasma is enhanced by a narrow range of added sphingosine 1-phosphate: implications for biomaterials design. | Journal of biomedical materials research. Part A 20090101 |
| Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system. | Cellular signalling 20090101 |
| Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I. | Endocrine journal 20090101 |
| Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. | Cellular signalling 20090101 |
| Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. | Journal of cellular physiology 20090101 |
| A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090101 |
| A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. | Analytical biochemistry 20090101 |
| The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an 'immature' vascular maturation factor to a 'mature' mediator of lymphocyte behavior and function. | Immunologic research 20090101 |
| Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator. | Journal of clinical pharmacology 20090101 |
| Effect of double bond geometry in sphingosine base on the antioxidant function of sphingomyelin. | Archives of biochemistry and biophysics 20090101 |
| Regulation by sphingolipids of the fate of FRTL-5 cells. | Journal of biochemistry 20090101 |
| Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. | Kidney international 20090101 |
| Regulation of vascular permeability by sphingosine 1-phosphate. | Microvascular research 20090101 |
| Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. | Plant physiology 20090101 |
| RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans. | Cellular and molecular life sciences : CMLS 20090101 |
| Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. | American journal of physiology. Heart and circulatory physiology 20090101 |
| Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. | Journal of neurochemistry 20090101 |
| An efficient and general enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives. | Organic letters 20090101 |
| Enhanced detection of sphingoid bases via divalent ruthenium bipyridine complex derivatization and electrospray ionization tandem mass spectrometry. | Analytical chemistry 20090101 |
| Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. | Bioorganic & medicinal chemistry 20090101 |
| An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation. | Clinical and experimental immunology 20090101 |
| Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration. | Surgery 20090101 |
| Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. | International journal of oncology 20090101 |
| Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. | PloS one 20090101 |
| Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. | Molecular cancer research : MCR 20090101 |
| [Lysophospholipid mediators]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090101 |
| Concepts in microvascular endothelial barrier regulation in health and disease. | Microvascular research 20090101 |
| Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. | Cellular & molecular biology letters 20090101 |
| The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. | Cellular & molecular biology letters 20090101 |
| GPR3 receptor, a novel actor in the emotional-like responses. | PloS one 20090101 |
| Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection. | International journal of immunopathology and pharmacology 20090101 |
| Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁. | International journal of molecular sciences 20090101 |
| Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue. | Immunologic research 20090101 |
| Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18. | PloS one 20090101 |
| Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids. | Angewandte Chemie (International ed. in English) 20090101 |
| The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study. | Annals of transplantation 20090101 |
| Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | International journal of medical sciences 20090101 |
| New aspects of sphingosine 1-phosphate signaling in mammalian cells. | Advances in enzyme regulation 20090101 |
| Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma. | Immunology and cell biology 20090101 |
| Mammalian Diaphanous (mDia) may be involved in the signal transduction of sphingosine-1-phosphate on developing actin stress fiber of human fibroblasts. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20090101 |
| Regulation of macrophage function by sphingosine-1-phosphate. | Immunobiology 20090101 |
| Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava. | Journal of oleo science 20090101 |
| FTY720 and everolimus in de novo renal transplant patients at risk for delayed graft function: results of an exploratory one-yr multicenter study. | Clinical transplantation 20090101 |
| Lipid generation and signaling in ovarian cancer. | Cancer treatment and research 20090101 |
| Lysophosphatidic acid and invasion. | Cancer treatment and research 20090101 |
| Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. | PloS one 20090101 |
| Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms. | Oncology research 20090101 |
| The discovery of novel experimental therapies for inflammatory arthritis. | Mediators of inflammation 20090101 |
| Choices and outcomes: Extending basic biology to clinical care. | Oxidative medicine and cellular longevity 20090101 |
| Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning. | Oxidative medicine and cellular longevity 20090101 |
| Asymmetric sulfur ylide based enantioselective synthesis of D-erythro-sphingosine. | Organic & biomolecular chemistry 20081221 |
| The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. | Current biology : CB 20081209 |
| Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells. | Stem cells and development 20081201 |
| Impaired initiation of contact hypersensitivity by FTY720. | The Journal of investigative dermatology 20081201 |
| Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. | Stroke 20081201 |
| Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina. | Neurochemistry international 20081201 |
| Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis. | American journal of physiology. Heart and circulatory physiology 20081201 |
| FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. | European journal of immunology 20081201 |
| RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. | Journal of immunology (Baltimore, Md. : 1950) 20081201 |
| Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | Journal of immunology (Baltimore, Md. : 1950) 20081201 |
| Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse. | Veterinary dermatology 20081201 |
| Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine. | Transplantation proceedings 20081201 |
| Retinal flavoprotein autofluorescence as a measure of retinal health. | Transactions of the American Ophthalmological Society 20081201 |
| Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis. | Bulletin of experimental biology and medicine 20081201 |
| Effects of ethanol and lipopolysaccharide on the sphingomyelin cycle in rat hepatocytes. | Bulletin of experimental biology and medicine 20081201 |
| Sphingosine 1-phosphate modulates spinal nociceptive processing. | The Journal of biological chemistry 20081121 |
| Synthesis of alpha-galactosyl ceramide (KRN7000) and analogues thereof via a common precursor and their preliminary biological assessment. | The Journal of organic chemistry 20081121 |
| Central nervous system-directed effects of FTY720 (fingolimod). | Journal of the neurological sciences 20081115 |
| WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. | Blood 20081115 |
| Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. | Journal of immunology (Baltimore, Md. : 1950) 20081115 |
| WASp stings mature lymphocytes. | Blood 20081115 |
| Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. | Circulation research 20081107 |
| Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. | Breast cancer research and treatment 20081101 |
| Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies. | Clinical neurology and neurosurgery 20081101 |
| Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. | Journal of lipid research 20081101 |
| Potential role of sphingosine 1-phosphate in the pathogenesis of rheumatoid arthritis. | Journal of lipid research 20081101 |
| Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival. | Transplant immunology 20081101 |
| High-throughput screening of cell lysates for ganglioside synthesis. | Analytical biochemistry 20081101 |
| S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. | Molecular immunology 20081101 |
| Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices. | American journal of physiology. Heart and circulatory physiology 20081101 |
| Sphingosine-1-phosphate acts as a developmental stage specific inhibitor of platelet-derived growth factor-induced chemotaxis of osteoblasts. | Journal of cellular biochemistry 20081101 |
| Expression patterns of the lysophospholipid receptor genes during mouse early development. | Developmental dynamics : an official publication of the American Association of Anatomists 20081101 |
| Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease. | Biological chemistry 20081101 |
| The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis. | Current opinion in investigational drugs (London, England : 2000) 20081101 |
| Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. | Nature medicine 20081101 |
| Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. | Translational research : the journal of laboratory and clinical medicine 20081101 |
| Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. | Archives of pharmacal research 20081101 |
| Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study. | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20081101 |
| Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species. | Biochemical and biophysical research communications 20081031 |
| A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. | Biochemical and biophysical research communications 20081031 |
| Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | Sheng li xue bao : [Acta physiologica Sinica] 20081025 |
| Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. | Biochemical and biophysical research communications 20081024 |
| FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. | Neurology 20081014 |
| Microwave-assisted synthesis of near-infrared fluorescent sphingosine derivatives. | Chemical communications (Cambridge, England) 20081007 |
| Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library. | Bioorganic chemistry 20081001 |
| K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. | Experimental dermatology 20081001 |
| Involvement of sphingosine kinase in plant cell signalling. | The Plant journal : for cell and molecular biology 20081001 |
| Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. | Cardiovascular research 20081001 |
| Lipid content of brain, brain membrane lipid domains, and neurons from acid sphingomyelinase deficient mice. | Journal of neurochemistry 20081001 |
| Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. | Experimental eye research 20081001 |
| Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. | American journal of physiology. Gastrointestinal and liver physiology 20081001 |
| Lipid metabolism: sources and stability of plasma sphingosine-1-phosphate. | Current opinion in lipidology 20081001 |
| Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. | The American journal of pathology 20081001 |
| The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. | The Journal of infectious diseases 20081001 |
| The alliance of sphingosine-1-phosphate and its receptors in immunity. | Nature reviews. Immunology 20081001 |
| Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates. | Acta pharmacologica Sinica 20081001 |
| Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. | Archives of ophthalmology (Chicago, Ill. : 1960) 20081001 |
| Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. | Molecular cancer research : MCR 20081001 |
| Human cytomegalovirus regulates bioactive sphingolipids. | The Journal of biological chemistry 20080919 |
| Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells. | Biochemical and biophysical research communications 20080912 |
| A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. | Circulation research 20080912 |
| High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function. | The Journal of biological chemistry 20080905 |
| Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor. | American journal of respiratory cell and molecular biology 20080901 |
| Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity. | Biochimica et biophysica acta 20080901 |
| K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. | The Journal of investigative dermatology 20080901 |
| Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. | Biochimica et biophysica acta 20080901 |
| G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. | Cardiovascular research 20080901 |
| FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. | Diabetes, obesity & metabolism 20080901 |
| A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. | Analytical biochemistry 20080901 |
| Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. | Biochimica et biophysica acta 20080901 |
| Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination. | Biochimica et biophysica acta 20080901 |
| Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. | Biochimica et biophysica acta 20080901 |
| Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. | Molecular pharmacology 20080901 |
| Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. | Biochimica et biophysica acta 20080901 |
| Sphingosine 1-phosphate chemical biology. | Biochimica et biophysica acta 20080901 |
| S1P and eNOS regulation. | Biochimica et biophysica acta 20080901 |
| The vascular S1P gradient-cellular sources and biological significance. | Biochimica et biophysica acta 20080901 |
| Sphingosine-1-phosphate regulation of mammalian development. | Biochimica et biophysica acta 20080901 |
| Transdermal delivery of carvedilol containing glycyrrhizin and chitosan as permeation enhancers: biochemical, biophysical, microscopic and pharmacodynamic evaluation. | Drug delivery 20080901 |
| Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. | Endocrinology 20080901 |
| Emerging oral drugs for multiple sclerosis. | Expert opinion on emerging drugs 20080901 |
| N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | Molecular cancer therapeutics 20080901 |
| Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. | Molecular cancer research : MCR 20080901 |
| [Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide]. | Wei sheng yan jiu = Journal of hygiene research 20080901 |
| A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. | Blood 20080815 |
| Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. | Blood 20080815 |
| TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity. | Bioorganic & medicinal chemistry 20080815 |
| Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. | Cancer research 20080815 |
| Immunology: Surprising side effects. | Nature 20080814 |
| Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection. | Nature 20080814 |
| Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. | Cancer letters 20080808 |
| Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a 'come-and-get-me' signal. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801 |
| Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate. | Cardiovascular research 20080801 |
| K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. | Journal of dermatological science 20080801 |
| Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. | Human molecular genetics 20080801 |
| HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. | Arteriosclerosis, thrombosis, and vascular biology 20080801 |
| Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols. | Journal of lipid research 20080801 |
| Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn. | Cellular signalling 20080801 |
| Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20080801 |
| The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects. | British journal of clinical pharmacology 20080801 |
| S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. | Gynecologic oncology 20080801 |
| Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. | Arteriosclerosis, thrombosis, and vascular biology 20080801 |
| Understanding the mechanisms of anaphylaxis. | Current opinion in allergy and clinical immunology 20080801 |
| Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness. | Circulation research 20080801 |
| Cell-culture-dependent change of Ca2+ response of rat aortic myocytes to sphingosine-1-phosphate. | Journal of pharmacological sciences 20080801 |
| Anti-tumor activity of phenoxodiol: from bench to clinic. | Future oncology (London, England) 20080801 |
| Infections cast cloud over Novartis' MS therapy. | Nature biotechnology 20080801 |
| Molecular targeting of acid ceramidase: implications to cancer therapy. | Current drug targets 20080801 |
| Azathioprine in multiple sclerosis. | Mini reviews in medicinal chemistry 20080801 |
| [SphK-1/S1P signal pathway in CML cells]. | Zhongguo shi yan xue ye xue za zhi 20080801 |
| Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. | Biophysical journal 20080715 |
| Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with Niemann-Pick disease types A and C, and Gaucher disease. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080715 |
| Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. | Biochemical and biophysical research communications 20080711 |
| Increased resistance of complex I mutants to phytosphingosine-induced programmed cell death. | The Journal of biological chemistry 20080711 |
| Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. | The Journal of biological chemistry 20080711 |
| Skeletal muscle wastage in Crohn's disease: a pathway shared with heart failure? | International journal of cardiology 20080704 |
| Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype. | The Journal of investigative dermatology 20080701 |
| Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701 |
| Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. | Neurochemical research 20080701 |
| Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues. | ChemMedChem 20080701 |
| Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. | Journal of lipid research 20080701 |
| Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. | Biomaterials 20080701 |
| Overexpression of TRPC3 reduces the content of intracellular calcium stores in HEK-293 cells. | Journal of cellular physiology 20080701 |
| Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. | The Journal of physiology 20080701 |
| Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. | Molecular and cellular biochemistry 20080701 |
| Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P. | Genes to cells : devoted to molecular & cellular mechanisms 20080701 |
| Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease. | European journal of immunology 20080701 |
| Fungicidal activity of truncated analogues of dihydrosphingosine. | Bioorganic & medicinal chemistry letters 20080701 |
| Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters. | Annals of clinical biochemistry 20080701 |
| Sphingobacterium kitahiroshimense sp. nov., isolated from soil. | International journal of systematic and evolutionary microbiology 20080701 |
| Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | Thrombosis and haemostasis 20080701 |
| N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. | Journal of pharmacological sciences 20080701 |
| Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. | Molecular cancer therapeutics 20080701 |
| S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. | Molecular cancer therapeutics 20080701 |
| Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. | Biochemical and biophysical research communications 20080620 |
| Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. | Journal of immunology (Baltimore, Md. : 1950) 20080615 |
| FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression. | Biochemical and biophysical research communications 20080613 |
| Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury. | Neuropathology and applied neurobiology 20080601 |
| Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos. | Molecular reproduction and development 20080601 |
| Lysophospholipid receptor-mediated calcium signaling in human keratinocytes. | The Journal of investigative dermatology 20080601 |
| S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake. | Journal of cellular biochemistry 20080601 |
| Biosynthesis of sphinganine-analog mycotoxins. | Journal of industrial microbiology & biotechnology 20080601 |
| An essential role for Rac1 in endothelial cell function and vascular development. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080601 |
| C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | Journal of neuroscience research 20080601 |
| Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate. | Cellular signalling 20080601 |
| Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | Prostaglandins & other lipid mediators 20080601 |
| Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. | Kidney international 20080601 |
| Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. | Cell death and differentiation 20080601 |
| Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. | Developmental neurobiology 20080601 |
| Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages. | Prostaglandins & other lipid mediators 20080601 |
| Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. | Prostaglandins & other lipid mediators 20080601 |
| Functional complementation of fumonisin biosynthesis in FUM1-disrupted fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici. | Journal of natural products 20080601 |
| Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. | Prostaglandins & other lipid mediators 20080601 |
| Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators. | Journal of immunology (Baltimore, Md. : 1950) 20080601 |
| Antinociceptive activity of the S1P-receptor agonist FTY720. | Journal of cellular and molecular medicine 20080601 |
| Interactions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells. | Endocrine-related cancer 20080601 |
| Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. | Biological & pharmaceutical bulletin 20080601 |
| 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets. | Pharmacological reviews 20080601 |
| Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. | Prostaglandins, leukotrienes, and essential fatty acids 20080601 |
| Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients. | Transplantation proceedings 20080601 |
| Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro. | Transplantation proceedings 20080601 |
| Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death. | Biochemical and biophysical research communications 20080530 |
| Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury? | Journal of neuroscience research 20080515 |
| New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. | Biochemical pharmacology 20080515 |
| Asymmetric synthesis of vicinal amino alcohols: xestoaminol C, sphinganine and sphingosine. | Organic & biomolecular chemistry 20080507 |
| Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition. | Organic & biomolecular chemistry 20080507 |
| S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. | The Journal of biological chemistry 20080502 |
| Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. | The Journal of biological chemistry 20080502 |
| Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. | Neurochemical research 20080501 |
| The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. | Cardiovascular research 20080501 |
| Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. | Cardiovascular research 20080501 |
| The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects. | European journal of clinical pharmacology 20080501 |
| Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells. | Histochemistry and cell biology 20080501 |
| The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin. | Journal of lipid research 20080501 |
| Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. | Blood 20080501 |
| Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure. | International immunology 20080501 |
| FTY720 (fingolimod) for relapsing multiple sclerosis. | Expert review of neurotherapeutics 20080501 |
| Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. | The Journal of biological chemistry 20080425 |
| Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. | Circulation research 20080425 |
| Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells. | Biochemical and biophysical research communications 20080418 |
| Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells. | Journal of cellular biochemistry 20080415 |
| Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. | Blood 20080415 |
| A fluorescent plate reader assay for ceramide kinase. | Analytical biochemistry 20080415 |
| The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen. | Journal of immunology (Baltimore, Md. : 1950) 20080415 |
| Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. | Journal of immunology (Baltimore, Md. : 1950) 20080415 |
| Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. | The Journal of biological chemistry 20080411 |
| Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. | The British journal of nutrition 20080401 |
| Fungal growth inhibitory properties of new phytosphingolipid analogues. | Journal of applied microbiology 20080401 |
| Ceramides modulate cell-surface acetylcholine receptor levels. | Biochimica et biophysica acta 20080401 |
| Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. | The Journal of pharmacology and experimental therapeutics 20080401 |
| Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. | Blood 20080401 |
| FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. | Experimental neurology 20080401 |
| Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. | International journal of hematology 20080401 |
| Functions of sphingolipid metabolism in mammals--lessons from genetic defects. | Biochimica et biophysica acta 20080401 |
| Mechanisms of organogenesis of primary lymphoid follicles. | International immunology 20080401 |
| Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis. | Pancreas 20080401 |
| Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod). | Chemical & pharmaceutical bulletin 20080401 |
| TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. | European journal of immunology 20080401 |
| Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice. | Transplantation proceedings 20080401 |
| Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632. | European journal of pharmacology 20080331 |
| Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. | Circulation research 20080328 |
| The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. | Circulation research 20080328 |
| The role of sphingosine kinase in a murine model of allergic asthma. | Journal of immunology (Baltimore, Md. : 1950) 20080315 |
| Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells. | FEBS letters 20080305 |
| Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? | Fertility and sterility 20080301 |
| Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes. | Osteoarthritis and cartilage 20080301 |
| Sphingolipid therapy in myocardial ischemia-reperfusion injury. | Biochimica et biophysica acta 20080301 |
| Sphingosylphosphorylcholine as a novel calmodulin inhibitor. | The Biochemical journal 20080301 |
| Plasma sphingosine 1-phosphate metabolism and analysis. | Biochimica et biophysica acta 20080301 |
| Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. | Biochimica et biophysica acta 20080301 |
| Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. | Prostaglandins & other lipid mediators 20080301 |
| Determination of sphingosine kinase activity for cellular signaling studies. | Analytical chemistry 20080301 |
| Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. | American journal of physiology. Heart and circulatory physiology 20080301 |
| Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion. | Human reproduction (Oxford, England) 20080301 |
| A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod. | Journal of clinical pharmacology 20080301 |
| Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. | Thrombosis and haemostasis 20080301 |
| The role of sphingosine-1-phosphate and its receptors in asthma. | Drug news & perspectives 20080301 |
| [Therapeutic effect of S1P receptor modifying drugs for autoimmune diseases]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080301 |
| Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83. | Circulation research 20080227 |
| Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. | The Journal of biological chemistry 20080227 |
| S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. | Biochemical and biophysical research communications 20080222 |
| Efficient and selective synthesis of D-arabino-, D-lyxo-, and D-xylo-phytosphingosine from D-ribo-phytosphingosine. | The Journal of organic chemistry 20080215 |
| FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. | Cancer research 20080215 |
| Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. | Molecular and cellular endocrinology 20080213 |
| Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells. | FEBS letters 20080206 |
| Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography. | ChemMedChem 20080201 |
| Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. | Diabetes 20080201 |
| Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes. | American journal of physiology. Heart and circulatory physiology 20080201 |
| An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate. | Chemistry and physics of lipids 20080201 |
| Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. | Hypertension (Dallas, Tex. : 1979) 20080201 |
| Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. | Journal of immunology (Baltimore, Md. : 1950) 20080201 |
| Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. | Journal of immunology (Baltimore, Md. : 1950) 20080201 |
| Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. | Critical care medicine 20080201 |
| Principles of bioactive lipid signalling: lessons from sphingolipids. | Nature reviews. Molecular cell biology 20080201 |
| Lipid signalling in disease. | Nature reviews. Molecular cell biology 20080201 |
| Targeting lipid metabolism in the treatment of hepatitis C virus infection. | The Journal of infectious diseases 20080201 |
| Sphingolipid receptors. | Biochemistry. Biokhimiia 20080201 |
| Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii. | Archives of pharmacal research 20080201 |
| Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. | British journal of cancer 20080115 |
| Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron. | The Journal of physiology 20080115 |
| Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. | Journal of immunology (Baltimore, Md. : 1950) 20080115 |
| Cell-nonautonomous function of ceramidase in photoreceptor homeostasis. | Neuron 20080110 |
| [Physiologically active substances derived from activated platelets: overview in clinical medicine]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20080110 |
| Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco. | Cell calcium 20080101 |
| Sphingosine kinase activity is required for myogenic differentiation of C2C12 myoblasts. | Journal of cellular physiology 20080101 |
| FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. | Blood 20080101 |
| Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. | Biophysical journal 20080101 |
| Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets. | Biochimica et biophysica acta 20080101 |
| FTY720 modulates human oligodendrocyte progenitor process extension and survival. | Annals of neurology 20080101 |
| Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. | American journal of physiology. Cell physiology 20080101 |
| Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. | Pharmacology & therapeutics 20080101 |
| Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives. | Bioorganic & medicinal chemistry letters 20080101 |
| Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. | British journal of pharmacology 20080101 |
| Follicular shuttling of marginal zone B cells facilitates antigen transport. | Nature immunology 20080101 |
| The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. | Nature immunology 20080101 |
| The multi-functional role of sphingosylphosphorylcholine. | Progress in lipid research 20080101 |
| Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. | Naunyn-Schmiedeberg's archives of pharmacology 20080101 |
| A role for S1P signalling in axon guidance in the Xenopus visual system. | Development (Cambridge, England) 20080101 |
| Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. | The American journal of pathology 20080101 |
| Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. | Surgery today 20080101 |
| Antibody-mediated rejection with a striking interstitial monocyte/macrophage infiltration in a renal allograft under FTY720 treatment. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20080101 |
| Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient. | Archives of ophthalmology (Chicago, Ill. : 1960) 20080101 |
| Tug of war at the exit door. | Immunity 20080101 |
| N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. | Archives of pharmacal research 20080101 |
| T-cell-targeted signaling inhibitors. | International reviews of immunology 20080101 |
| Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720. | Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20080101 |
| Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. | Journal of biochemical and molecular toxicology 20080101 |
| Sphingolipids in macroautophagy. | Methods in molecular biology (Clifton, N.J.) 20080101 |
| FTY720 treatment in experimentally urethane-induced lung tumors. | Journal of experimental therapeutics & oncology 20080101 |
| Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine. | Reviews on recent clinical trials 20080101 |
| Biological effects of lysophospholipids. | Reviews of physiology, biochemistry and pharmacology 20080101 |
| Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry. | European journal of mass spectrometry (Chichester, England) 20080101 |
| Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies. | The Mount Sinai journal of medicine, New York 20080101 |
| Lysophosphatidic acid (LPA) and angiogenesis. | Angiogenesis 20080101 |
| Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. | Cerebrovascular diseases (Basel, Switzerland) 20080101 |
| Stratification of sphingosine kinase-1 expression and activity in rat kidney. | Cells, tissues, organs 20080101 |
| The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology. | Endothelium : journal of endothelial cell research 20080101 |
| Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models. | Immunopharmacology and immunotoxicology 20080101 |
| Glycosylceramides obtain from the starfish Asterias amurensis Lütken. | Journal of oleo science 20080101 |
| Lysophospholipid activation of G protein-coupled receptors. | Sub-cellular biochemistry 20080101 |
| Multiple roles for sphingolipids in steroid hormone biosynthesis. | Sub-cellular biochemistry 20080101 |
| Roles of bioactive sphingolipids in cancer biology and therapeutics. | Sub-cellular biochemistry 20080101 |
| Sphingolipid metabolizing enzymes as novel therapeutic targets. | Sub-cellular biochemistry 20080101 |
| New insights on mast cell activation via the high affinity receptor for IgE. | Advances in immunology 20080101 |
| Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. | Acta neurobiologiae experimentalis 20080101 |
| Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. | BioFactors (Oxford, England) 20080101 |
| [Cordyceps sinensis, a fungi used in the Chinese traditional medicine]. | Revista iberoamericana de micologia 20071231 |
| An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. | Analytical biochemistry 20071215 |
| Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus). | Chemico-biological interactions 20071215 |
| Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury. | International immunopharmacology 20071215 |
| Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. | Journal of medicinal chemistry 20071213 |
| Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells. | Biochemical and biophysical research communications 20071207 |
| Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis. | Organic & biomolecular chemistry 20071207 |
| HDL and its sphingosine-1-phosphate content in cardioprotection. | Heart failure reviews 20071201 |
| S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. | Neurochemistry international 20071201 |
| Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice. | Neurochemical research 20071201 |
| Reorganization of prion protein membrane environment during low potassium-induced apoptosis in primary rat cerebellar neurons. | Journal of neurochemistry 20071201 |
| Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. | Glia 20071201 |
| Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways. | American journal of physiology. Renal physiology 20071201 |
| Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | American journal of physiology. Regulatory, integrative and comparative physiology 20071201 |
| Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy. | Bioorganic & medicinal chemistry letters 20071201 |
| Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes. | Journal of neurochemistry 20071201 |
| Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. | Nature immunology 20071201 |
| Finding a way out: lymphocyte egress from lymphoid organs. | Nature immunology 20071201 |
| Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells. | Stem cells and development 20071201 |
| Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. | Cell research 20071201 |
| [Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review]. | Zhongguo shi yan xue ye xue za zhi 20071201 |
| FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury. | Transplantation proceedings 20071201 |
| Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes. | Transplantation proceedings 20071201 |
| Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation. | Journal of vascular surgery 20071201 |
| Therapeutic targeting of leukocyte trafficking across the blood-brain barrier. | Inflammation & allergy drug targets 20071201 |
| The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. | Archives of pharmacal research 20071201 |
| [Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20071201 |
| Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. | The Journal of biological chemistry 20071123 |
| Validation of fumonisin biomarkers in F344 rats. | Toxicology and applied pharmacology 20071115 |
| Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720. | European journal of pharmacology 20071114 |
| Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts. | FEBS letters 20071113 |
| Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. | FEBS letters 20071113 |
| Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. | Circulation research 20071109 |
| Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds. | Molecular and cellular biochemistry 20071101 |
| Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD). | Blood 20071101 |
| Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. | The Journal of pharmacology and experimental therapeutics 20071101 |
| Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells. | American journal of physiology. Cell physiology 20071101 |
| HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. | Journal of lipid research 20071101 |
| S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. | Gynecologic oncology 20071101 |
| The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. | The Journal of pharmacology and experimental therapeutics 20071101 |
| Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20071101 |
| Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | The Prostate 20071101 |
| Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. | Journal of immunology (Baltimore, Md. : 1950) 20071101 |
| Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. | Journal of immunology (Baltimore, Md. : 1950) 20071101 |
| Constituents of Crinoidea. 5. Isolation and structure of a new glycosyl inositolphosphoceramide-type ganglioside from the feather star Comanthina schlegeli. | Chemical & pharmaceutical bulletin 20071101 |
| A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). | Prostaglandins & other lipid mediators 20071101 |
| Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells. | Prostaglandins & other lipid mediators 20071101 |
| Paucity of pericytes in germinal matrix vasculature of premature infants. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071031 |
| Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes. | The Journal of organic chemistry 20071026 |
| FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. | Brain research bulletin 20071019 |
| Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. | Cancer letters 20071018 |
| Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. | Expert reviews in molecular medicine 20071015 |
| FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study. | Transplantation 20071015 |
| Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. | FEBS letters 20071002 |
| Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells. | Journal of cellular physiology 20071001 |
| Trypanosoma cruzi epimastigotes: regulation of myo-inositol transport by effectors of protein kinases A and C. | Experimental parasitology 20071001 |
| Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways. | Journal of lipid research 20071001 |
| A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. | Cardiovascular research 20071001 |
| Distribution of sphingosine kinase activity and mRNA in rodent brain. | Journal of neurochemistry 20071001 |
| Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism. | The Journal of pharmacology and experimental therapeutics 20071001 |
| The acylation of lipophilic alcohols by lysosomal phospholipase A2. | Journal of lipid research 20071001 |
| Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. | American journal of physiology. Heart and circulatory physiology 20071001 |
| Cell-specific expression of neutral glycosphingolipids in vertebrate brain: immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes. | Journal of neuroscience research 20071001 |
| Sphingosine 1-phosphate accelerates wound healing in diabetic mice. | Journal of dermatological science 20071001 |
| Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes. | European journal of pharmacology 20071001 |
| [FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis]. | Der Nervenarzt 20071001 |
| Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase. | American journal of physiology. Cell physiology 20071001 |
| Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. | British journal of pharmacology 20071001 |
| Fingolimod: a novel immunosuppressant for multiple sclerosis. | The Annals of pharmacotherapy 20071001 |
| The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers. | Transplant international : official journal of the European Society for Organ Transplantation 20071001 |
| Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. | The Journal of clinical investigation 20071001 |
| Biomarkers of exposure to fumonisin mycotoxins: a review. | Food additives and contaminants 20071001 |
| Autocrine and paracrine roles of sphingosine-1-phosphate. | Trends in endocrinology and metabolism: TEM 20071001 |
| Effect of FTY720 on apoptosis of smooth muscle cells. | Transplantation proceedings 20071001 |
| Sphingolipid signaling pathways as potential therapeutic targets in gliomas. | Mini reviews in medicinal chemistry 20071001 |
| Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. | Autonomic & autacoid pharmacology 20071001 |
| [Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis]. | Zhonghua xin xue guan bing za zhi 20071001 |
| Sphingosine 1-phosphate promotes antigen processing and presentation to CD4+ T cells in Mycobacterium tuberculosis-infected monocytes. | Biochemical and biophysical research communications 20070928 |
| Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its synthesis to its degradation. | The Journal of biological chemistry 20070928 |
| Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. | Developmental biology 20070915 |
| Ceramide-induced cell death in lens epithelial cells. | Molecular vision 20070910 |
| FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. | Cancer letters 20070908 |
| Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. | Nature 20070906 |
| FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. | The Journal of clinical investigation 20070904 |
| Recent advances in the glycosylation of sphingosines and ceramides. | Carbohydrate research 20070903 |
| Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation. | Atherosclerosis 20070901 |
| Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901 |
| Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences. | Journal of molecular graphics & modelling 20070901 |
| Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. | Journal of lipid research 20070901 |
| Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. | Journal of biochemistry 20070901 |
| Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. | Pharmacology & therapeutics 20070901 |
| Chronic toxicity of fumonisins in turkeys. | Poultry science 20070901 |
| Sphingosine 1-phosphate as a novel immune regulator of dendritic cells. | Journal of biosciences 20070901 |
| Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. | The Journal of physiology 20070815 |
| Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. | Molecular and cellular endocrinology 20070815 |
| HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate. | Biochemical and biophysical research communications 20070803 |
| Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine [jaspine B]. | The Journal of organic chemistry 20070803 |
| A concise and scalable synthesis of high enantiopurity (-)-D-erythro-sphingosine using peptidyl thiol ester-boronic acid cross-coupling. | Organic letters 20070802 |
| Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms. | Cellular signalling 20070801 |
| Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. | Cellular signalling 20070801 |
| Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors. | Journal of neurochemistry 20070801 |
| Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. | Molecular pharmacology 20070801 |
| The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801 |
| Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. | Critical reviews in oncology/hematology 20070801 |
| Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities. | Arteriosclerosis, thrombosis, and vascular biology 20070801 |
| A higher plant delta8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants. | Plant physiology 20070801 |
| New sphingolipids with a previously unreported 9-methyl-C20-sphingosine moiety from a marine algous endophytic fungus Aspergillus niger EN-13. | Lipids 20070801 |
| A rice dihydrosphingosine C4 hydroxylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem, may be involved in fertility. | Plant & cell physiology 20070801 |
| Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070801 |
| Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells. | Journal of neurochemistry 20070801 |
| Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. | Journal of immunology (Baltimore, Md. : 1950) 20070801 |
| Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. | Anesthesia and analgesia 20070801 |
| Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. | The European journal of neuroscience 20070801 |
| Enantioselective synthesis of pachastrissamine (jaspin B) using dirhodium(II)-catalyzed C-H amination and asymmetric dihydroxylation as key steps. | Chemical & pharmaceutical bulletin 20070801 |
| FTY720: a most promising immunosuppressant modulating immune cell functions. | Mini reviews in medicinal chemistry 20070801 |
| FTY720 improves survival after transient ischemia and reperfusion of the hind limbs. | The Journal of trauma 20070801 |
| (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | Molecular cancer research : MCR 20070801 |
| Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai. | Memorias do Instituto Oswaldo Cruz 20070801 |
| Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | Archives of pharmacal research 20070801 |
| The immunomodulator FTY720 is phosphorylated and released from platelets. | European journal of pharmacology 20070730 |
| Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine. | Transplantation 20070727 |
| Fluid shear stress enhances the sphingosine 1-phosphate responses in cell-cell interactions between platelets and endothelial cells. | Biochemical and biophysical research communications 20070713 |
| Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. | The Journal of biological chemistry 20070713 |
| Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. | Biochemical and biophysical research communications 20070706 |
| The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701 |
| Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. | Immunology 20070701 |
| Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate. | Biology of reproduction 20070701 |
| Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. | Stem cells (Dayton, Ohio) 20070701 |
| FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. | Molecular immunology 20070701 |
| Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. | Naunyn-Schmiedeberg's archives of pharmacology 20070701 |
| Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines. | European journal of immunology 20070701 |
| Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. | Pharmacology & therapeutics 20070701 |
| Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. | Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20070701 |
| Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors. | The Journal of pharmacy and pharmacology 20070701 |
| Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. | Neurological research 20070701 |
| Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. | Biochemical pharmacology 20070630 |
| Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. | Neuroscience letters 20070629 |
| FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3. | FEBS letters 20070626 |
| Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. | Biochemical and biophysical research communications 20070622 |
| Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation. | Cellular signalling 20070601 |
| Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | American journal of respiratory cell and molecular biology 20070601 |
| Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase. | Biochimica et biophysica acta 20070601 |
| S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis. | American journal of physiology. Renal physiology 20070601 |
| Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities. | Annals of the New York Academy of Sciences 20070601 |
| The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins alpha(5)beta(1) and alpha(v)beta(3). | Journal of thrombosis and haemostasis : JTH 20070601 |
| Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. | Arteriosclerosis, thrombosis, and vascular biology 20070601 |
| The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma. | International immunology 20070601 |
| Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver. | Prostaglandins & other lipid mediators 20070601 |
| Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. | Journal of immunology (Baltimore, Md. : 1950) 20070601 |
| Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis. | Expert opinion on pharmacotherapy 20070601 |
| Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation. | Molecular cancer research : MCR 20070601 |
| Very early alloantigen-independent trafficking of lymphocytes during ischemic acute kidney injury. | Kidney international 20070601 |
| Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. | The Journal of biological chemistry 20070525 |
| Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. | The Journal of biological chemistry 20070525 |
| Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. | Biochemical and biophysical research communications 20070525 |
| Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | Cancer letters 20070518 |
| Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. | Bioorganic & medicinal chemistry 20070515 |
| Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. | Bioorganic & medicinal chemistry letters 20070515 |
| Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | The Journal of biological chemistry 20070511 |
| Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. | Journal of cellular physiology 20070501 |
| The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. | Journal of cellular biochemistry 20070501 |
| Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | Blood 20070501 |
| Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501 |
| Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. | Journal of cellular physiology 20070501 |
| Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. | Journal of dermatological science 20070501 |
| Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | Journal of vascular surgery 20070501 |
| Characterization of novel myelin components 3-O-acetyl-sphingosine galactosylceramides by electrospray ionization Q-TOF MS and MS/CID-MS of Li+ adducts. | Journal of mass spectrometry : JMS 20070501 |
| Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. | Experimental cell research 20070501 |
| basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. | Genetics 20070501 |
| Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | Journal of immunology (Baltimore, Md. : 1950) 20070501 |
| Novel oral agents for multiple sclerosis. | Current neurology and neuroscience reports 20070501 |
| Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. | The European journal of neuroscience 20070501 |
| [Host-selective toxins and their receptors]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20070501 |
| The role of lysosphingolipids in the regulation of biological processes. | Biochemistry. Biokhimiia 20070501 |
| Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins. | Experimental & molecular medicine 20070430 |
| S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | Biochemical and biophysical research communications 20070427 |
| Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. | The Journal of biological chemistry 20070420 |
| Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3. | Biochemical and biophysical research communications 20070420 |
| Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | Life sciences 20070417 |
| Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK. | Journal of cellular biochemistry 20070415 |
| The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | Gene 20070415 |
| Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | The Journal of biological chemistry 20070413 |
| Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. | Science (New York, N.Y.) 20070413 |
| Immunology. The sources of a lipid conundrum. | Science (New York, N.Y.) 20070413 |
| Fumonisin B(1): oxidative status and DNA damage in rats. | Toxicology 20070411 |
| Letter by Xia regarding article, 'High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor'. | Circulation 20070410 |
| Deafness and stria vascularis defects in S1P2 receptor-null mice. | The Journal of biological chemistry 20070406 |
| Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. | Cellular signalling 20070401 |
| Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. | American journal of physiology. Endocrinology and metabolism 20070401 |
| Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | Molecular & cellular proteomics : MCP 20070401 |
| Erythrocytes store and release sphingosine 1-phosphate in blood. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070401 |
| Sphingosine-1-phosphate signaling in the cardiovascular system. | Current opinion in pharmacology 20070401 |
| Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. | The Journal of biological chemistry 20070401 |
| Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. | International immunology 20070401 |
| Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | Cardiovascular research 20070401 |
| Mechanism of mitochondrial 7A6 antigen exposure triggered by distinct apoptotic pathways: involvement of caspases. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070401 |
| FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. | British journal of pharmacology 20070401 |
| Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. | Cardiovascular research 20070401 |
| Anti-angiogenic effect of tetraacetyl-phytosphingosine. | Experimental dermatology 20070401 |
| Current perspectives on FTY720. | Expert opinion on investigational drugs 20070401 |
| Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain. | Alcoholism, clinical and experimental research 20070401 |
| Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. | Neuropharmacology 20070401 |
| Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070401 |
| Sphingosine 1-phosphate in neural signalling and function. | Acta paediatrica (Oslo, Norway : 1992) 20070401 |
| Vascular effects of sphingolipids. | Acta paediatrica (Oslo, Norway : 1992) 20070401 |
| Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. | Acta paediatrica (Oslo, Norway : 1992) 20070401 |
| Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes. | Journal of pharmacological sciences 20070401 |
| Novel therapies for microvascular permeability in sepsis. | Current drug targets 20070401 |
| [Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401 |
| Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. | Journal of Korean medical science 20070401 |
| Development of a simple and robust assay to screen for inhibitors of sphingosine kinases. | Assay and drug development technologies 20070401 |
| Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | Archives of pharmacal research 20070401 |
| [Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis]. | Rinsho byori. The Japanese journal of clinical pathology 20070401 |
| Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. | The Journal of biological chemistry 20070323 |
| MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. | The Journal of biological chemistry 20070316 |
| Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. | Journal of immunology (Baltimore, Md. : 1950) 20070315 |
| Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients. | Transplantation 20070315 |
| Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. | The Journal of biological chemistry 20070309 |
| Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa. | The Journal of biological chemistry 20070302 |
| Synthesis of borondipyrromethene (BODIPY)-labeled sphingosine derivatives by cross-metathesis reaction. | The Journal of organic chemistry 20070302 |
| The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20070301 |
| Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium. | Journal of lipid research 20070301 |
| Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects. | Biopharmaceutics & drug disposition 20070301 |
| Tipping the gatekeeper: S1P regulation of endothelial barrier function. | Trends in immunology 20070301 |
| FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. | Expert opinion on investigational drugs 20070301 |
| Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. | Acta pharmacologica Sinica 20070301 |
| Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. | Journal of neurochemistry 20070301 |
| On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | Biological chemistry 20070301 |
| The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. | Immunity 20070301 |
| Sphingosine-1-phosphate and FTY720 as anti-atherosclerotic lipid compounds. | European journal of clinical investigation 20070301 |
| Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. | Cell cycle (Georgetown, Tex.) 20070301 |
| FTY720 application following isolated warm liver ischemia improves long-term survival and organ protection in a mouse model. | Transplantation proceedings 20070301 |
| FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia; impact on long-term survival and T-lymphocyte tissue infiltration. | Transplantation proceedings 20070301 |
| A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. | Molecular cancer therapeutics 20070301 |
| PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301 |
| Chemokines and chemokine receptors in renal transplantation--from bench to bedside. | Acta physiologica Hungarica 20070301 |
| Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. | Progress in lipid research 20070301 |
| FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury. | Journal of cellular and molecular medicine 20070301 |
| Multiple actions of dimethylsphingosine in 1321N1 astrocytes. | Molecules and cells 20070227 |
| Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. | World journal of gastroenterology 20070221 |
| FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. | Journal of immunology (Baltimore, Md. : 1950) 20070215 |
| Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. | Cancer research 20070215 |
| Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. | Oncogene 20070208 |
| Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207 |
| Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator. | American journal of physiology. Cell physiology 20070201 |
| Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. | Cellular signalling 20070201 |
| The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. | Cellular signalling 20070201 |
| Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. | American journal of physiology. Heart and circulatory physiology 20070201 |
| The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. | Blood 20070201 |
| L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. | Gynecologic oncology 20070201 |
| Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. | The Journal of pharmacology and experimental therapeutics 20070201 |
| Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate. | Molecular endocrinology (Baltimore, Md.) 20070201 |
| Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. | Chemistry and physics of lipids 20070201 |
| Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. | Arteriosclerosis, thrombosis, and vascular biology 20070201 |
| Steroidogenic factor-1 is a sphingolipid binding protein. | Molecular and cellular endocrinology 20070201 |
| Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. | International journal of oncology 20070201 |
| Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats. | Journal of veterinary pharmacology and therapeutics 20070201 |
| Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | British journal of pharmacology 20070201 |
| TRP channels activated by extracellular hypo-osmoticity in epithelia. | Biochemical Society transactions 20070201 |
| Bipolar phospholipid sensing by TRPC5 calcium channel. | Biochemical Society transactions 20070201 |
| Regulation and functional roles of sphingosine kinases. | Naunyn-Schmiedeberg's archives of pharmacology 20070201 |
| Synthesis of pachastrissamine from phytosphingosine: a comparison of cyclic sulfate vs an epoxide intermediate in cyclization. | Organic letters 20070201 |
| Pioglitazone induces de novo ceramide synthesis in the rat heart. | Prostaglandins & other lipid mediators 20070201 |
| Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. | Diabetes 20070201 |
| Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells. | Cellular and molecular life sciences : CMLS 20070201 |
| Ethnic sensitivity study of fingolimod in white and Asian subjects. | International journal of clinical pharmacology and therapeutics 20070201 |
| [Effect of mono and combination therapy with FTY720 and ICAM-1 mAb for mouse-to-rat cardiac xenotransplantation]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070201 |
| Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. | Archives of pharmacal research 20070201 |
| Lysophospholipid receptors in cell signaling. | Biochemistry. Biokhimiia 20070201 |
| [The effects of sphingosine-1 1-phosphate (SIP) on the action potential and contractile in guinea pig ventricular myocardium]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201 |
| FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. | Circulation 20070130 |
| Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | The Journal of biological chemistry 20070126 |
| Functions of the multifaceted family of sphingosine kinases and some close relatives. | The Journal of biological chemistry 20070126 |
| Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | The Journal of biological chemistry 20070119 |
| Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. | The Journal of biological chemistry 20070119 |
| Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. | Bioorganic & medicinal chemistry letters 20070115 |
| Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? | Free radical biology & medicine 20070115 |
| Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols. | Free radical biology & medicine 20070115 |
| Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases. | Cancer research 20070115 |
| Dihydroxylation of 2-vinylaziridine: efficient synthesis of D-ribo-phytosphingosine. | Chemical communications (Cambridge, England) 20070107 |
| Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | Toxicology 20070105 |
| Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. | Circulation research 20070105 |
| Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. | Circulation research 20070105 |
| Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. | American journal of physiology. Cell physiology 20070101 |
| Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. | Stem cells (Dayton, Ohio) 20070101 |
| Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? | Autophagy 20070101 |
| SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. | Genetics 20070101 |
| Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. | Fertility and sterility 20070101 |
| Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines. | Frontiers in bioscience : a journal and virtual library 20070101 |
| Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5. | Oncology reports 20070101 |
| Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. | Neurochemical research 20070101 |
| FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease. | European journal of immunology 20070101 |
| Cytochemical alterations in the rat retina by LPS administration. | Neurochemical research 20070101 |
| Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients. | International immunopharmacology 20070101 |
| Multiple sclerosis: new insights and therapeutic progress. | The Lancet. Neurology 20070101 |
| Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. | The American journal of pathology 20070101 |
| Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | Scandinavian journal of immunology 20070101 |
| Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. | Molecular cancer therapeutics 20070101 |
| Effects of LPA and S1P on the nervous system and implications for their involvement in disease. | Current drug targets 20070101 |
| New immunosuppresor strategies in the treatment of murine lupus nephritis. | Lupus 20070101 |
| A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine. | Archives of pharmacal research 20070101 |
| Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? | Neurochemical research 20070101 |
| FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. | Anticancer research 20070101 |
| Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes. | BMC musculoskeletal disorders 20070101 |
| N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation. | Bioconjugate chemistry 20070101 |
| Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice. | Microsurgery 20070101 |
| Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells. | The international journal of biochemistry & cell biology 20070101 |
| Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. | Drug and chemical toxicology 20070101 |
| Analysis of sphingosine 1-phosphate by capillary electrophoresis coupled to laser-induced fluorescence detection: use of a transparent fused-silica capillary. | Journal of capillary electrophoresis and microchip technology 20070101 |
| Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries. | Journal of combinatorial chemistry 20070101 |
| A Novel sulfatide, GlcCer-I6 sulfate, from the ascidian Ciona intestinalis. | Journal of oleo science 20070101 |
| Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | Journal of biochemical and molecular toxicology 20070101 |
| Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. | Methods in enzymology 20070101 |
| A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. | Methods in enzymology 20070101 |
| Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20070101 |
| Sphingosine-1-phosphate signaling and the skin. | American journal of clinical dermatology 20070101 |
| Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells. | Pharmacological reports : PR 20070101 |
| Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation. | Transplantation 20061227 |
| FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs. | International immunopharmacology 20061220 |
| FTY720 in combination with cyclosporine--an analysis of skin allograft survival and renal function. | International immunopharmacology 20061220 |
| Tacrolimus in combination with FTY720--an analysis of renal and blood parameters. | International immunopharmacology 20061220 |
| Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. | The EMBO journal 20061213 |
| Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. | Biochimica et biophysica acta 20061201 |
| S1P regulation of ovarian carcinoma invasiveness. | Gynecologic oncology 20061201 |
| Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. | Endocrinology 20061201 |
| New developments in the biological functions of lysophospholipids. | Cellular and molecular life sciences : CMLS 20061201 |
| Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. | Journal of lipid research 20061201 |
| Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. | Biochimica et biophysica acta 20061201 |
| Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | Journal of thrombosis and haemostasis : JTH 20061201 |
| Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). | The Journal of biological chemistry 20061201 |
| Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? | Clinical immunology (Orlando, Fla.) 20061201 |
| Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. | Journal of toxicology and environmental health. Part A 20061201 |
| FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20061201 |
| Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. | Biochimica et biophysica acta 20061201 |
| LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | Prostaglandins & other lipid mediators 20061201 |
| Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. | Journal of cell science 20061201 |
| A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. | Biochimica et biophysica acta 20061201 |
| Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation. | Transplantation proceedings 20061201 |
| Exposure-efficacy relationships of a fingolimod-everolimus regimen in kidney transplant patients at risk for delayed graft function. | Transplantation proceedings 20061201 |
| [Phosphodiesterases that extracellularly produces a lysolipid mediator]. | Seikagaku. The Journal of Japanese Biochemical Society 20061201 |
| Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate. | Stem cells and development 20061201 |
| Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | Cellular & molecular immunology 20061201 |
| Stereoselective synthesis of jaspine B from D-xylose. | Carbohydrate research 20061127 |
| Versatile synthetic method for sphingolipids and functionalized sphingosine derivatives via olefin cross metathesis. | Organic letters 20061123 |
| Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines. | International journal of pharmaceutics 20061115 |
| Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061115 |
| Measurement and stability of FTY720 in human whole blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107 |
| Targeting sphingosine-1-phosphate for cancer therapy. | British journal of cancer 20061106 |
| Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. | Progress in lipid research 20061101 |
| Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. | Journal of cellular biochemistry 20061101 |
| Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. | Endocrinology 20061101 |
| Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. | Stem cells (Dayton, Ohio) 20061101 |
| PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. | Journal of neurochemistry 20061101 |
| Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway. | Apoptosis : an international journal on programmed cell death 20061101 |
| Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. | Hepatology (Baltimore, Md.) 20061101 |
| Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents. | Experimental biology and medicine (Maywood, N.J.) 20061101 |
| Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | Investigative ophthalmology & visual science 20061101 |
| Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells. | Journal of pharmacological sciences 20061101 |
| Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. | The Journal of clinical investigation 20061101 |
| Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. | The Journal of endocrinology 20061101 |
| The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. | PLoS biology 20061101 |
| Effect of FTY720 in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes in gut-associated lymphoid tissues. | Transplantation proceedings 20061101 |
| The curtain is drawn for both natalizumab and fingolimod (FTY720): a new era of multiple sclerosis therapy has arrived. | Expert review of neurotherapeutics 20061101 |
| Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. | Archives of pharmacal research 20061101 |
| Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101 |
| Efficient synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine via a cyclic sulfate intermediate. | The Journal of organic chemistry 20061027 |
| Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. | The Journal of biological chemistry 20061020 |
| Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry. | The Journal of biological chemistry 20061013 |
| Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. | Cellular signalling 20061001 |
| De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | Cellular signalling 20061001 |
| Bioactive sphingolipids in the modulation of the inflammatory response. | Pharmacology & therapeutics 20061001 |
| Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. | Endocrinology 20061001 |
| Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation. | Clinical and experimental immunology 20061001 |
| The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice. | Oncology reports 20061001 |
| Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. | Acta pharmacologica Sinica 20061001 |
| Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. | The Journal of biological chemistry 20060929 |
| Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. | Biochemical and biophysical research communications 20060929 |
| Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | Circulation research 20060929 |
| Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. | Circulation research 20060929 |
| High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. | Circulation 20060926 |
| Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. | Neuroscience 20060915 |
| Highly sensitive determination of N-acyl dihydrosphingosine using liquid chromatography-electrospray ionization mass spectrometry. Application to human hair lipids. | Journal of chromatography. A 20060915 |
| Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. | The New England journal of medicine 20060914 |
| Oral fingolimod (FTY720) for relapsing multiple sclerosis. | The New England journal of medicine 20060914 |
| Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells. | Cellular signalling 20060901 |
| Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. | Histochemistry and cell biology 20060901 |
| Molecular requirements for doxorubicin-mediated death in murine oocytes. | Cell death and differentiation 20060901 |
| Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. | Blood 20060901 |
| Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. | Journal of neurophysiology 20060901 |
| Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses. | Drug metabolism and disposition: the biological fate of chemicals 20060901 |
| Dietary sphingolipids suppress a subset of preneoplastic rat liver lesions exhibiting high PTEN, low phospho-Akt and high levels of ceramide species. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901 |
| C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. | Endocrinology 20060901 |
| Sphingosine, a product of ceramide hydrolysis, influences the formation of ceramide channels. | Biophysical journal 20060901 |
| Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. | Cardiovascular research 20060901 |
| Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060901 |
| Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. | American journal of physiology. Heart and circulatory physiology 20060901 |
| Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060901 |
| [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. | Wei sheng yan jiu = Journal of hygiene research 20060901 |
| Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. | The Journal of biological chemistry 20060825 |
| Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | The Journal of physiology 20060815 |
| Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. | Circulation research 20060804 |
| Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | Journal of cellular biochemistry 20060801 |
| FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. | American journal of physiology. Gastrointestinal and liver physiology 20060801 |
| Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. | The Biochemical journal 20060801 |
| Antitumor activity of sphingosine kinase inhibitors. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS. | Glycobiology 20060801 |
| Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | Journal of lipid research 20060801 |
| IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. | Journal of leukocyte biology 20060801 |
| FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060801 |
| Membrane guanylyl cyclase receptors: an update. | Trends in endocrinology and metabolism: TEM 20060801 |
| The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | European journal of immunology 20060801 |
| Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | Nature chemical biology 20060801 |
| Lipid-induced phenotypes. | Nature chemical biology 20060801 |
| FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects. | Journal of clinical pharmacology 20060801 |
| Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast. | FEMS yeast research 20060801 |
| Sphingosine and ceramide signalling in apoptosis. | IUBMB life 20060801 |
| Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. | IUBMB life 20060801 |
| [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. | Zhongguo shi yan xue ye xue za zhi 20060801 |
| Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. | Archives of pharmacal research 20060801 |
| [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics]. | Seikagaku. The Journal of Japanese Biochemical Society 20060801 |
| An efficient high-yield synthesis of D-ribo-phytosphingosine. | Organic letters 20060720 |
| Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5. | The Biochemical journal 20060715 |
| Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. | Journal of cell science 20060715 |
| Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. | The Journal of biological chemistry 20060707 |
| 9-O-acetyl GD3 protects tumor cells from apoptosis. | International journal of cancer 20060701 |
| Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor. | Molecular pharmacology 20060701 |
| Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. | Journal of cellular physiology 20060701 |
| Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. | Neuropharmacology 20060701 |
| 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. | Bioorganic & medicinal chemistry letters 20060701 |
| Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. | Neurobiology of disease 20060701 |
| Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. | Prostaglandins & other lipid mediators 20060701 |
| The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. | Prostaglandins & other lipid mediators 20060701 |
| A ceramide and cerebroside from the starfish asterias amurensis Lütken and their plant-growth promotion activities. | Journal of natural products 20060701 |
| [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | Rinsho byori. The Japanese journal of clinical pathology 20060701 |
| Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. | Biochemical and biophysical research communications 20060623 |
| Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. | Biochemical and biophysical research communications 20060623 |
| Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720. | Bioorganic & medicinal chemistry 20060615 |
| Apoptosis of human colon carcinoma HT-29 cells induced by ceramide. | World journal of gastroenterology 20060614 |
| Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells. | Biochemical and biophysical research communications 20060609 |
| A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. | Circulation research 20060609 |
| Enantiodivergent synthesis of D- and L-erythro-sphingosines through Mannich-type reactions of N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone. | The Journal of organic chemistry 20060609 |
| Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. | American journal of physiology. Renal physiology 20060601 |
| Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. | Journal of cellular physiology 20060601 |
| The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. | Journal of lipid research 20060601 |
| Sphingosine increases the permeability of model and cell membranes. | Biophysical journal 20060601 |
| Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. | Journal of lipid research 20060601 |
| Pulmonary and vascular pharmacology of sphingosine 1-phosphate. | Current opinion in pharmacology 20060601 |
| Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. | European journal of immunology 20060601 |
| Sphingosine impairs mitochondrial function by opening permeability transition pore. | Mitochondrion 20060601 |
| Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | Molecular cancer therapeutics 20060601 |
| Mice lacking both TNFalpha receptors show increased constitutive expression of IFNgamma: a possible reason for lack of protection from fumonisin B1 hepatotoxicity. | Cytokine 20060601 |
| Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. | Biochemical and biophysical research communications 20060526 |
| Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. | Biochemical and biophysical research communications 20060519 |
| Glycosynthase-mediated synthesis of glycosphingolipids. | Journal of the American Chemical Society 20060517 |
| The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. | Toxicology 20060515 |
| Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures. | Investigational new drugs 20060501 |
| Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | Journal of neurochemistry 20060501 |
| Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Valpha19 NKT cell with alpha-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit. | European journal of medicinal chemistry 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. | Prostaglandins & other lipid mediators 20060501 |
| Efflux of sphingolipids metabolically labeled with [1-3H]sphingosine, L-[3- 3H]serine and [9,10- 3H]palmitic acid from normal cells in culture. | Glycoconjugate journal 20060501 |
| The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. | The Journal of biological chemistry 20060428 |
| [Inhibition of alphastatin on angiogenesis in human endothelial cells and the mechanism thereof: an experimental study]. | Zhonghua yi xue za zhi 20060418 |
| Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | Glia 20060415 |
| Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. | Experimental cell research 20060415 |
| Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha. | Cell death and differentiation 20060401 |
| Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. | American journal of physiology. Cell physiology 20060401 |
| Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity. | Journal of cellular physiology 20060401 |
| Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401 |
| Semisynthetic sphingoglycolipid LIGA20 is neuroprotective against human immunodeficiency virus-gp120-mediated apoptosis. | Journal of neuroscience research 20060401 |
| Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. | Naunyn-Schmiedeberg's archives of pharmacology 20060401 |
| Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. | Naunyn-Schmiedeberg's archives of pharmacology 20060401 |
| Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. | Pigment cell research 20060401 |
| Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? | Cardiovascular research 20060401 |
| Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | Cardiovascular research 20060401 |
| Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | Cardiovascular research 20060401 |
| Ceramide is a mediator of apoptosis in retina photoreceptors. | Investigative ophthalmology & visual science 20060401 |
| Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. | Naunyn-Schmiedeberg's archives of pharmacology 20060401 |
| Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | Journal of pharmacological sciences 20060401 |
| In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils. | American journal of veterinary research 20060401 |
| Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. | Biomacromolecules 20060401 |
| Evidence that FTY720 induces rat thymocyte apoptosis. | Transplant immunology 20060401 |
| FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells. | Transplant immunology 20060401 |
| FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia in C57/BL6 mice. | Transplantation proceedings 20060401 |
| TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes. | Cytokine 20060401 |
| Sphingosine kinase: biochemical and cellular regulation and role in disease. | Journal of biochemistry and molecular biology 20060331 |
| A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs. | Organic & biomolecular chemistry 20060321 |
| Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. | The Journal of biological chemistry 20060317 |
| Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. | Developmental biology 20060315 |
| Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. | The Journal of biological chemistry 20060310 |
| Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | Chemico-biological interactions 20060310 |
| Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. | Chemico-biological interactions 20060310 |
| Ceramide-induced preconditioning involves reactive oxygen species. | Life sciences 20060306 |
| Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. | The Journal of biological chemistry 20060303 |
| A photoreactive analogue of the immunosuppressant FTY720. | The Journal of organic chemistry 20060303 |
| Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration. | Cellular signalling 20060301 |
| Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. | Endocrinology 20060301 |
| Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. | Journal of lipid research 20060301 |
| Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. | Molecular pharmacology 20060301 |
| Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. | Molecular pharmacology 20060301 |
| Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. | Journal of lipid research 20060301 |
| Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060301 |
| Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | Genes to cells : devoted to molecular & cellular mechanisms 20060301 |
| Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. | Journal of mass spectrometry : JMS 20060301 |
| Phenoxodiol: isoflavone analog with antineoplastic activity. | Current oncology reports 20060301 |
| Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. | Arthritis and rheumatism 20060301 |
| Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. | Cancer cell 20060301 |
| Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. | Cancer cell 20060301 |
| S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. | The European journal of neuroscience 20060301 |
| The role of the phospholipid sphingomyelin in heart disease. | Current opinion in investigational drugs (London, England : 2000) 20060301 |
| Meeting report: Barossa 2005--Signaling Networks. | Science's STKE : signal transduction knowledge environment 20060227 |
| Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. | Molecules and cells 20060227 |
| Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. | Biochemical and biophysical research communications 20060224 |
| FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. | Cancer letters 20060220 |
| Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient with Fabry disease. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217 |
| Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups. | Organic letters 20060216 |
| Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. | Blood 20060215 |
| Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis. | The Biochemical journal 20060215 |
| Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | Free radical biology & medicine 20060215 |
| A direct organocatalytic entry to sphingoids: asymmetric synthesis of D-arabino- and L-ribo-phytosphingosine. | Chemical communications (Cambridge, England) 20060214 |
| Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. | The Journal of biological chemistry 20060210 |
| IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. | The Journal of biological chemistry 20060203 |
| Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) from D-xylose. | The Journal of organic chemistry 20060203 |
| Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. | American journal of physiology. Lung cellular and molecular physiology 20060201 |
| Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. | American journal of respiratory cell and molecular biology 20060201 |
| Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | The Journal of pharmacology and experimental therapeutics 20060201 |
| Influence of chain length and unsaturation on sphingomyelin bilayers. | Biophysical journal 20060201 |
| Sphingosine kinase 1 is up-regulated in colon carcinogenesis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201 |
| Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201 |
| Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. | Journal of molecular and cellular cardiology 20060201 |
| Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? | British journal of pharmacology 20060201 |
| Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. | British journal of pharmacology 20060201 |
| Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. | European journal of cancer (Oxford, England : 1990) 20060201 |
| Emerging medicinal roles for lysophospholipid signaling. | Trends in molecular medicine 20060201 |
| Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin. | Journal of immunology (Baltimore, Md. : 1950) 20060201 |
| Fingolimod (FTY720) in severe hepatic impairment: pharmacokinetics and relationship to markers of liver function. | Journal of clinical pharmacology 20060201 |
| Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes. | Journal of biochemistry 20060201 |
| CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | Immunity 20060201 |
| [Disturbances of antimicrobial lipids in atopic dermatitis]. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060201 |
| [Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants]. | Nihon rinsho. Japanese journal of clinical medicine 20060201 |
| Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. | Cellular & molecular immunology 20060201 |
| An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine. | The Journal of organic chemistry 20060120 |
| Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. | The Biochemical journal 20060115 |
| Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival. | Journal of immunology (Baltimore, Md. : 1950) 20060115 |
| Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study. | International journal of pharmaceutics 20060113 |
| Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. | Biology of reproduction 20060101 |
| Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. | The Journal of surgical research 20060101 |
| Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20060101 |
| NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. | Bioorganic & medicinal chemistry letters 20060101 |
| Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101 |
| Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. | Archives of biochemistry and biophysics 20060101 |
| The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. | British journal of pharmacology 20060101 |
| ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria. | Biochimica et biophysica acta 20060101 |
| Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection. | Journal of immunology (Baltimore, Md. : 1950) 20060101 |
| Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. | Apoptosis : an international journal on programmed cell death 20060101 |
| Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. | Cancer research 20060101 |
| Gene transfer mediated by sphingosine/ dioleoylphosphatidylethanolamine liposomes in the presence of poloxamer 188. | Drug delivery 20060101 |
| Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | Current pharmaceutical design 20060101 |
| Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. | Anticancer research 20060101 |
| Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. | Biochimica et biophysica acta 20060101 |
| Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | Immunological investigations 20060101 |
| [New ceramides from sea sponge Oceanapia sp]. | Bioorganicheskaia khimiia 20060101 |
| The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. | Archivum immunologiae et therapiae experimentalis 20060101 |
| Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. | Molecular medicine (Cambridge, Mass.) 20060101 |
| Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line. | BMC bioinformatics 20060101 |
| Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. | TheScientificWorldJournal 20060101 |
| Quantification of the wound healing using polarization-sensitive optical coherence tomography. | Journal of biomedical optics 20060101 |
| Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway. | The international journal of biochemistry & cell biology 20060101 |
| Transport across the endothelium: regulation of endothelial permeability. | Handbook of experimental pharmacology 20060101 |
| S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. | Journal of applied toxicology : JAT 20060101 |
| FTY720 (fingolimod) in renal transplantation. | Clinical transplantation 20060101 |
| Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants. | Clinical transplantation 20060101 |
| Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. | Molecular cancer 20060101 |
| Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. | Current pharmaceutical design 20060101 |
| Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells. | Doklady. Biochemistry and biophysics 20060101 |
| The mechanism of membrane targeting of human sphingosine kinase 1. | The Journal of biological chemistry 20051230 |
| Sphingosine releases Ca2+ from intracellular stores via the ryanodine receptor in sea urchin egg homogenates. | Biochemical and biophysical research communications 20051223 |
| An efficient synthesis of D-erythro- and D-threo-sphingosine from D-glucose: olefin cross-metathesis approach. | Organic letters 20051222 |
| FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. | International journal of cancer 20051220 |
| The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. | Journal of immunology (Baltimore, Md. : 1950) 20051215 |
| Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. | Cancer research 20051215 |
| Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | The Journal of organic chemistry 20051209 |
| FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. | Pharmacology & therapeutics 20051201 |
| Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine. | Toxicology 20051201 |
| Influence of phytosphingosine-type ceramides on the structure of DMPC membrane. | Chemistry and physics of lipids 20051201 |
| Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. | Cell calcium 20051201 |
| Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. | Nature immunology 20051201 |
| Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. | European journal of immunology 20051201 |
| Two ligands for a GPCR, proton vs lysolipid. | Acta pharmacologica Sinica 20051201 |
| Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. | Journal of immunology (Baltimore, Md. : 1950) 20051201 |
| Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | Journal of neurochemistry 20051201 |
| FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051201 |
| Multiple sclerosis poses tough drug development challenges. | Drug discovery today 20051201 |
| Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury. | Transplantation proceedings 20051201 |
| Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. | Transplantation proceedings 20051201 |
| FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. | Cellular & molecular immunology 20051201 |
| Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051123 |
| Characterization of the bactericidal effect of dietary sphingosine and its activity under intestinal conditions. | International journal of food microbiology 20051115 |
| Effect of FTY720 on chronic cyclosporine nephropathy in rats. | Transplantation 20051115 |
| Chirality transfer from guanidinium ylides to 3-alkenyl (or 3-alkynyl) aziridine-2-carboxylates and application to the syntheses of (2R,3S)-3-hydroxyleucinate and D-erythro-sphingosine. | The Journal of organic chemistry 20051111 |
| Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | The Journal of biological chemistry 20051104 |
| Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. | The Journal of biological chemistry 20051104 |
| Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants. | The Journal of biological chemistry 20051104 |
| Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | Journal of lipid research 20051101 |
| beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. | The Journal of nutritional biochemistry 20051101 |
| Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes. | Journal of lipid research 20051101 |
| Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101 |
| C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma. | Oncology reports 20051101 |
| The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051101 |
| C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration. | Naunyn-Schmiedeberg's archives of pharmacology 20051101 |
| FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship. | Journal of clinical pharmacology 20051101 |
| Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. | Biochemical Society transactions 20051101 |
| Candida albicans serotype B strains synthesize a serotype-specific phospholipomannan overexpressing a beta-1,2-linked mannotriose. | Molecular microbiology 20051101 |
| Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. | Progress in lipid research 20051101 |
| FTY720 inhibits TH1-mediated allogeneic humoral immune response. | Transplantation proceedings 20051101 |
| [Establishment of a method for determining the sphingosine kinase activity and its initial application]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101 |
| APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans. | The Journal of biological chemistry 20051028 |
| One-step labelling of sphingolipids via a scrambling cross-metathesis reaction. | Chemical communications (Cambridge, England) 20051028 |
| Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. | Journal of cell science 20051015 |
| The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | The Journal of biological chemistry 20051007 |
| Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. | Oncogene 20051006 |
| Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. | Cardiovascular research 20051001 |
| Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. | The Biochemical journal 20051001 |
| Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. | Cellular signalling 20051001 |
| Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue. | Cardiovascular research 20051001 |
| Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. | Journal of pharmacological sciences 20051001 |
| Inflammation and perturbation of the l-carnitine system in heart failure. | European journal of heart failure 20051001 |
| [Multiple sclerosis. A new oral immunomodulator]. | Medizinische Monatsschrift fur Pharmazeuten 20051001 |
| A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925 |
| Endothelial/pericyte interactions. | Circulation research 20050916 |
| Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates. | Toxicology 20050915 |
| Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice. | Toxicon : official journal of the International Society on Toxinology 20050915 |
| Immunology. Dietary factors and immunological consequences. | Science (New York, N.Y.) 20050909 |
| Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | Science (New York, N.Y.) 20050909 |
| Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050901 |
| Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | Journal of lipid research 20050901 |
| Differential regulation of NPR-B/GC-B by protein kinase c and calcium. | Biochemical pharmacology 20050901 |
| Regulation of vascular reactivity by established and emerging GPCRs. | Trends in pharmacological sciences 20050901 |
| Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | European journal of immunology 20050901 |
| Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | Prostaglandins & other lipid mediators 20050901 |
| Lysophospholipids in the nervous system. | Prostaglandins & other lipid mediators 20050901 |
| Chemical approaches to the lysophospholipid receptors. | Prostaglandins & other lipid mediators 20050901 |
| Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | Journal of immunology (Baltimore, Md. : 1950) 20050901 |
| Sphingosine-1-phosphate mediates migration of mature dendritic cells. | Journal of immunology (Baltimore, Md. : 1950) 20050901 |
| Protein kinases influence bovine oocyte competence during short-term treatment with recombinant human follicle stimulating hormone. | Reproduction (Cambridge, England) 20050901 |
| [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20050901 |
| Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. | Molecular cancer therapeutics 20050901 |
| Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt. | Thrombosis and haemostasis 20050901 |
| A new turning point in glycosphingolipid research. | Human cell 20050901 |
| The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. | Blood 20050815 |
| Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. | Journal of neuroscience research 20050815 |
| FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. | Cancer research 20050815 |
| Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. | Journal of medicinal chemistry 20050811 |
| Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | American journal of physiology. Heart and circulatory physiology 20050801 |
| HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. | American journal of physiology. Cell physiology 20050801 |
| Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. | Endocrinology 20050801 |
| Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. | Journal of leukocyte biology 20050801 |
| The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. | Molecular pharmacology 20050801 |
| Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. | Bioorganic & medicinal chemistry letters 20050801 |
| The crystal structure of human CD1d with and without alpha-galactosylceramide. | Nature immunology 20050801 |
| Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies. | Archives of biochemistry and biophysics 20050801 |
| [Effects of sphingosine 1-phosphate on functions of T cell - review]. | Zhongguo shi yan xue ye xue za zhi 20050801 |
| Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. | Annals of biomedical engineering 20050801 |
| Sphingosine forms channels in membranes that differ greatly from those formed by ceramide. | Journal of bioenergetics and biomembranes 20050801 |
| Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | Naunyn-Schmiedeberg's archives of pharmacology 20050801 |
| Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | The Journal of biological chemistry 20050729 |
| Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. | FEBS letters 20050718 |
| Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. | The Journal of biological chemistry 20050715 |
| Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. | Biochemical pharmacology 20050715 |
| Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. | The Biochemical journal 20050701 |
| Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | Blood 20050701 |
| Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. | Cellular signalling 20050701 |
| TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. | Journal of leukocyte biology 20050701 |
| Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | Toxicological sciences : an official journal of the Society of Toxicology 20050701 |
| Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. | Experimental dermatology 20050701 |
| Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. | Birth defects research. Part A, Clinical and molecular teratology 20050701 |
| Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | Nature reviews. Immunology 20050701 |
| Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701 |
| Sphingosine 1-phosphate-related metabolism in the blood vessel. | Journal of biochemistry 20050701 |
| Protection of mouse small bowel allografts by FTY720 and costimulation blockade. | Transplantation 20050627 |
| Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. | The Journal of biological chemistry 20050617 |
| The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. | The Journal of biological chemistry 20050617 |
| FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. | Transplantation 20050615 |
| 2n-fatty acids from phosphatidylcholine label sphingolipids--a novel role of phospholipase A2? | Biochimica et biophysica acta 20050615 |
| Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. | The Journal of organic chemistry 20050610 |
| Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. | The Journal of biological chemistry 20050603 |
| Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. | Biochemical and biophysical research communications 20050603 |
| Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. | American journal of physiology. Cell physiology 20050601 |
| Chloride channel activity in human lung fibroblasts and myofibroblasts. | American journal of physiology. Lung cellular and molecular physiology 20050601 |
| Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. | Cellular signalling 20050601 |
| Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050601 |
| Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. | Methods (San Diego, Calif.) 20050601 |
| Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. | Biochimica et biophysica acta 20050601 |
| Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in experimental autoimmune encephalitis. | Journal of magnetic resonance imaging : JMRI 20050601 |
| LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. | Investigative ophthalmology & visual science 20050601 |
| Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. | American journal of hematology 20050601 |
| Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | Genes to cells : devoted to molecular & cellular mechanisms 20050601 |
| Off the shelf but not mass produced. | Chemistry & biology 20050601 |
| S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. | Chemistry & biology 20050601 |
| A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3. | Cellular and molecular neurobiology 20050601 |
| Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. | The Journal of biological chemistry 20050520 |
| Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. | Bioorganic & medicinal chemistry 20050516 |
| Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. | Transplantation 20050515 |
| Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. | FEBS letters 20050509 |
| Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | Journal of lipid research 20050501 |
| A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501 |
| Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. | British journal of pharmacology 20050501 |
| Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | Arteriosclerosis, thrombosis, and vascular biology 20050501 |
| Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase. | Analytical biochemistry 20050501 |
| Signal transduction in human endothelial cells induced by their interaction with group B Streptococci. | International journal of molecular medicine 20050501 |
| Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050501 |
| Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. | Nature medicine 20050501 |
| Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. | Experimental dermatology 20050501 |
| Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | Diabetes 20050501 |
| GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501 |
| Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. | Biochimica et biophysica acta 20050501 |
| Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050501 |
| [Skin barrier dysfunction in atopic dermatitis]. | Nihon rinsho. Japanese journal of clinical medicine 20050501 |
| Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. | Prostaglandins & other lipid mediators 20050501 |
| Induction of apoptosis in chicken oviduct cells by C2-ceramide. | Molecules and cells 20050430 |
| Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. | The Journal of biological chemistry 20050429 |
| Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. | Circulation research 20050429 |
| A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis. | Regulatory peptides 20050415 |
| Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel. | Archives of biochemistry and biophysics 20050415 |
| Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | Biochemical and biophysical research communications 20050408 |
| Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | American journal of physiology. Cell physiology 20050401 |
| Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. | Molecular pharmacology 20050401 |
| Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease. | Histology and histopathology 20050401 |
| Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | Analytical biochemistry 20050401 |
| FTY720 pharmacokinetics in mild to moderate hepatic impairment. | Journal of clinical pharmacology 20050401 |
| FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. | Pancreas 20050401 |
| A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice. | Biological & pharmaceutical bulletin 20050401 |
| Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050401 |
| Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. | Die Pharmazie 20050401 |
| Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | The Journal of biological chemistry 20050318 |
| Sphingosine 1-phosphate analogs as receptor antagonists. | The Journal of biological chemistry 20050318 |
| [Study of the effects of immunosuppressive agents on human islet cells in vitro]. | Zhonghua yi xue za zhi 20050316 |
| Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels. | Journal of cell science 20050315 |
| Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B). | Organic letters 20050303 |
| Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. | Molecular pharmacology 20050301 |
| The role of sphingosine-1-phosphate in smooth muscle contraction. | Cellular signalling 20050301 |
| Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target. | Carcinogenesis 20050301 |
| Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301 |
| Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. | Development (Cambridge, England) 20050301 |
| The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050301 |
| Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. | Journal of neurochemistry 20050301 |
| Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. | Journal of immunology (Baltimore, Md. : 1950) 20050301 |
| On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach. | Basic & clinical pharmacology & toxicology 20050301 |
| Sphingosine kinase signalling in immune cells. | Clinical and experimental pharmacology & physiology 20050301 |
| Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. | The American journal of pathology 20050301 |
| FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix. | Chemistry and physics of lipids 20050301 |
| Study on action mode of sphingosine 1-phosphate in rat hepatocytes. | Journal of pharmacological sciences 20050301 |
| Fingolimod. Mitsubishi Pharma/Novartis. | IDrugs : the investigational drugs journal 20050301 |
| Preoperative administration of FTY720 prolonged renal allograft survival. | Transplant immunology 20050301 |
| Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. | Journal of oral science 20050301 |
| Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. | Molecular and cellular endocrinology 20050227 |
| Novel mediators of FTY720 in human lymphocytes. | Transplantation 20050227 |
| Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. | Biochemical and biophysical research communications 20050218 |
| Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. | Brain research. Molecular brain research 20050218 |
| Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. | Blood 20050215 |
| Synthesis and biological properties of novel sphingosine derivatives. | Bioorganic & medicinal chemistry letters 20050215 |
| FTY720 in corneal concordant xenotransplantation. | Transplantation 20050215 |
| Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. | FEBS letters 20050214 |
| Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209 |
| Synthesis of alpha-series ganglioside GM1alpha containing C20-sphingosine. | Carbohydrate research 20050207 |
| In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. | Cellular signalling 20050201 |
| c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | Cellular signalling 20050201 |
| Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. | Journal of leukocyte biology 20050201 |
| A rapid radioassay for sphingosine kinase. | Analytical biochemistry 20050201 |
| The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells. | European journal of immunology 20050201 |
| Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. | Proceedings of the National Academy of Sciences of the United States of America 20050201 |
| Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. | Plant physiology 20050201 |
| Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation. | Reproduction (Cambridge, England) 20050201 |
| Phytosphingosine induced mitochondria-involved apoptosis. | Cancer science 20050201 |
| Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner. | Biological chemistry 20050201 |
| An increase of MMP-1 is stimulated by sphingosine in keloid fibroblasts. | The Journal of dermatology 20050201 |
| The role of sphingosine and ceramide kinases in inflammatory responses. | Immunology letters 20050131 |
| Sphingolipid uptake by cultured cells: complex aggregates of cell sphingolipids with serum proteins and lipoproteins are rapidly catabolized. | The Journal of biological chemistry 20050128 |
| Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice. | World journal of gastroenterology 20050128 |
| KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. | Circulation 20050118 |
| Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. | Bioorganic & medicinal chemistry 20050117 |
| Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca(2+) elevation. | FEBS letters 20050117 |
| Fungal metabolite sulfamisterin suppresses sphingolipid synthesis through inhibition of serine palmitoyltransferase. | Biochemistry 20050111 |
| Interaction of cholesterol with sphingosine: physicochemical characterization and impact on intestinal absorption. | Journal of lipid research 20050101 |
| High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | Atherosclerosis 20050101 |
| Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | Atherosclerosis 20050101 |
| Polymorphism of ceramide 6: a vibrational spectroscopic and X-ray powder diffraction investigation of the diastereomers of N-(alpha-hydroxyoctadecanoyl)-phytosphingosine. | Chemistry and physics of lipids 20050101 |
| Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes. | Medical science monitor : international medical journal of experimental and clinical research 20050101 |
| A convenient synthesis of immunosuppressive agent FTY720 using the petasis reaction. | Chemical & pharmaceutical bulletin 20050101 |
| FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050101 |
| Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. | Eukaryotic cell 20050101 |
| Chronic effects of fumonisin B1 on ducks. | Poultry science 20050101 |
| Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. | Journal of vascular surgery 20050101 |
| Similarities of cow mammary gland cytosolic 21-kDa protein, the substrate for protein kinase C, to the 20-kDa myosin light chain from smooth muscle. | The Journal of veterinary medical science 20050101 |
| The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | Thrombosis research 20050101 |
| Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. | Annual review of immunology 20050101 |
| [New immunodepressant drugs for the prevention and control of kidney transplant rejection]. | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101 |
| Anticancer compounds and sphingolipid metabolism in the colon. | In vivo (Athens, Greece) 20050101 |
| Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate. | Transplantation proceedings 20050101 |
| Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice. | Transplantation proceedings 20050101 |
| FTY720 inhibits tumor growth and angiogenesis. | Transplantation proceedings 20050101 |
| Prolonged administration of FTY720 does not cause renal toxicity in mice. | Transplantation proceedings 20050101 |
| Control of intestinal allograft rejection by FTY720 and costimulation blockade. | Transplantation proceedings 20050101 |
| FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury. | Transplantation proceedings 20050101 |
| Total synthesis and biological activities of (+)-sulfamisterin (AB5366) and its analogues. | The Journal of antibiotics 20050101 |
| Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | Respiratory research 20050101 |
| Inhibition of gene expression in vivo using multiplex siRNA. | Methods in molecular biology (Clifton, N.J.) 20050101 |
| The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs. | Surgery today 20050101 |
| Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. | Journal of molecular neuroscience : MN 20050101 |
| Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. | Stem cells (Dayton, Ohio) 20050101 |
| [Effects of PACAP and C2-ceramide on motility of cerebellar granule neurons: the fastest is not the farthest]. | Medecine sciences : M/S 20050101 |
| Effect of sphingosine on Ca2+ entry and mitochondrial potential of Jurkat T cells--interaction with Bcl2. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101 |
| Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models. | Arzneimittel-Forschung 20050101 |
| A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. | Journal of inherited metabolic disease 20050101 |
| Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. | The Kobe journal of medical sciences 20050101 |
| Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures. | Developmental neuroscience 20050101 |
| Modulation of ERK1/2 activity is crucial for sphingosine-induced death of glioma C6 cells. | Acta biochimica Polonica 20050101 |
| Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells. | Endothelium : journal of endothelial cell research 20050101 |
| Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. | Acta biomaterialia 20050101 |
| NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. | BioFactors (Oxford, England) 20050101 |
| FTY720: mechanism of action and potential benefit in organ transplantation. | Yonsei medical journal 20041231 |
| Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. | The Journal of biological chemistry 20041224 |
| The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. | The Journal of biological chemistry 20041217 |
| FTY720 suppresses humoral immunity by inhibiting germinal center reaction. | Blood 20041215 |
| Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. | The Journal of biological chemistry 20041210 |
| Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. | The Journal of biological chemistry 20041203 |
| Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition. | FEBS letters 20041203 |
| Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | American journal of physiology. Cell physiology 20041201 |
| FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. | Carcinogenesis 20041201 |
| Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | Cell death and differentiation 20041201 |
| Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | Biology of reproduction 20041201 |
| Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. | Journal of cancer research and clinical oncology 20041201 |
| Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. | Cell motility and the cytoskeleton 20041201 |
| Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. | Biochemical pharmacology 20041201 |
| Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. | The Journal of surgical research 20041201 |
| Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | Journal of neurochemistry 20041201 |
| Overview of FTY720 clinical pharmacokinetics and pharmacology. | Therapeutic drug monitoring 20041201 |
| Novel immunosuppressants. | Pediatric transplantation 20041201 |
| Production profile of the major allergen Alt a 1 in Alternaria alternata cultures. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041201 |
| Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. | Bioscience, biotechnology, and biochemistry 20041201 |
| Cerebroside analogues from marine-derived fungus Aspergillus flavipes. | Journal of Asian natural products research 20041201 |
| Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | The Journal of reproduction and development 20041201 |
| The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20041201 |
| Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. | Circulation 20041130 |
| Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | The Journal of biological chemistry 20041126 |
| High-density lipoprotein stimulates myocardial perfusion in vivo. | Circulation 20041123 |
| Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. | FEBS letters 20041119 |
| The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils. | Biochemical pharmacology 20041115 |
| Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | American journal of respiratory and critical care medicine 20041101 |
| Rejection following donor or recipient preoperative treatment with FTY720 in rat small bowel transplantation. | Transplant immunology 20041101 |
| Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. | British journal of pharmacology 20041101 |
| Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures. | The Journal of investigative dermatology 20041101 |
| Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. | Kidney international 20041101 |
| The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana. | The Plant journal : for cell and molecular biology 20041101 |
| Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. | British journal of pharmacology 20041101 |
| Lung injury: sphingosine-1-phosphate to the rescue. | American journal of respiratory and critical care medicine 20041101 |
| [Challenge to a riddle of brain: neuroglycobiology in retrospect and anticipation]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20041101 |
| Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | Current opinion in investigational drugs (London, England : 2000) 20041101 |
| Forward chemical genetics: library scaffold design. | Combinatorial chemistry & high throughput screening 20041101 |
| Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | The Journal of trauma 20041101 |
| A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments. | Transplant international : official journal of the European Society for Organ Transplantation 20041101 |
| ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. | Endocrine research 20041101 |
| Synthesis of 7-oxasphingosine and -ceramide analogues and their evaluation in a model for apoptosis. | Chemistry & biodiversity 20041101 |
| Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | Experimental & molecular medicine 20041031 |
| Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells. | Experimental & molecular medicine 20041031 |
| Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | Circulation research 20041029 |
| An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. | The Journal of organic chemistry 20041029 |
| Efficient synthesis of alpha-C-galactosyl ceramide immunostimulants: use of ethylene-promoted olefin cross-metathesis. | Organic letters 20041028 |
| Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase. | The Journal of biological chemistry 20041022 |
| G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. | The Journal of biological chemistry 20041008 |
| Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | The Journal of biological chemistry 20041008 |
| Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | Circulation 20041005 |
| Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | Bioorganic & medicinal chemistry letters 20041004 |
| The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. | European biophysics journal : EBJ 20041001 |
| A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling. | Pediatric surgery international 20041001 |
| Rat intestinal ceramidase: purification, properties, and physiological relevance. | American journal of physiology. Gastrointestinal and liver physiology 20041001 |
| Cell surface receptors in lysophospholipid signaling. | Seminars in cell & developmental biology 20041001 |
| Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. | Seminars in cell & developmental biology 20041001 |
| Physiological and pathological actions of sphingosine 1-phosphate. | Seminars in cell & developmental biology 20041001 |
| Modulation of adaptive immune responses by sphingosine-1-phosphate. | Seminars in cell & developmental biology 20041001 |
| Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. | Seminars in cell & developmental biology 20041001 |
| Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis. | Kidney international 20041001 |
| Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells. | Fertility and sterility 20041001 |
| Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. | Fundamental & clinical pharmacology 20041001 |
| mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | Zhongguo shi yan xue ye xue za zhi 20041001 |
| High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | The Journal of veterinary medical science 20041001 |
| Modulation by sphingosine of phosphorylation of substrate proteins by protein kinase C in nuclei from cow mammary gland. | The Journal of veterinary medical science 20041001 |
| Effects of FTY720 on rat lymphoid organs. | Transplantation proceedings 20041001 |
| Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation. | Stem cells and development 20041001 |
| Sphingosine 1-phosphate breakdown in platelets. | Journal of biochemistry 20041001 |
| [Immunossupresive drugs in renal transplantation]. | Polskie Archiwum Medycyny Wewnetrznej 20041001 |
| Skin lipid synthesis inhibition: a possible means for enhancing percutaneous delivery of levodopa. | Current drug delivery 20041001 |
| Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | The Journal of biological chemistry 20040924 |
| Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720. | Bioorganic & medicinal chemistry 20040915 |
| Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway. | Journal of immunology (Baltimore, Md. : 1950) 20040915 |
| Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. | The Journal of biological chemistry 20040910 |
| MuLK, a eukaryotic multi-substrate lipid kinase. | The Journal of biological chemistry 20040910 |
| Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine. | The Biochemical journal 20040901 |
| Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | The Biochemical journal 20040901 |
| The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901 |
| Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901 |
| Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | British journal of pharmacology 20040901 |
| Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration. | Kidney international 20040901 |
| Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | Journal of thrombosis and haemostasis : JTH 20040901 |
| A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice. | Biological & pharmaceutical bulletin 20040901 |
| The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior. | Biophysical journal 20040901 |
| Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. | The Journal of laboratory and clinical medicine 20040901 |
| Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. | The Journal of biological chemistry 20040827 |
| Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. | The Journal of biological chemistry 20040820 |
| In vivo influence of ceramide accumulation induced by treatment with a glucosylceramide synthase inhibitor on ischemic neuronal cell death. | Brain research 20040820 |
| Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine. | The Journal of organic chemistry 20040820 |
| Endothelial cell barrier regulation by sphingosine 1-phosphate. | Journal of cellular biochemistry 20040815 |
| Mechanisms of cardioprotection by lysophospholipids. | Journal of cellular biochemistry 20040815 |
| Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. | Journal of cellular biochemistry 20040815 |
| Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | Experimental cell research 20040815 |
| Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids. | The Journal of biological chemistry 20040813 |
| Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon. | The Journal of organic chemistry 20040806 |
| PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. | The EMBO journal 20040804 |
| Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | Circulation 20040803 |
| Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. | Toxicological sciences : an official journal of the Society of Toxicology 20040801 |
| Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | The Biochemical journal 20040801 |
| Inhibition of phospholipase C-epsilon by Gi-coupled receptors. | Cellular signalling 20040801 |
| The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801 |
| Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801 |
| Prosaposin: a new player in cell death prevention of U937 monocytic cells. | Experimental cell research 20040801 |
| Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | Experimental cell research 20040801 |
| An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. | Analytical biochemistry 20040801 |
| Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. | Journal of cellular biochemistry 20040801 |
| Generation and metabolism of bioactive sphingosine-1-phosphate. | Journal of cellular biochemistry 20040801 |
| Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for 'old' ligands. | Journal of cellular biochemistry 20040801 |
| Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | Atherosclerosis 20040801 |
| Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. | Journal of neuroimmunology 20040801 |
| Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | Journal of immunology (Baltimore, Md. : 1950) 20040801 |
| Biologically active sphingolipids in cancer pathogenesis and treatment. | Nature reviews. Cancer 20040801 |
| Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. | Cancer research 20040801 |
| New sphingosines from a gorgonian, Pseudopterogorgia australiensis Ridley, of the Indian Ocean. | Journal of natural products 20040801 |
| Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks. | Poultry science 20040801 |
| Separation and characterisation of sphingoceramides by high-performance liquid chromatography-electrospray ionisation mass spectrometry. | Journal of separation science 20040801 |
| Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences. | The Journal of biological chemistry 20040730 |
| Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. | Biochemical and biophysical research communications 20040730 |
| D-galactosyl-beta1-1'-sphingosine and D-glucosyl-beta1-1'-sphingosine induce human natural killer cell apoptosis. | Biochemical and biophysical research communications 20040730 |
| Prolactin acts as a potent survival factor for human breast cancer cell lines. | British journal of cancer 20040719 |
| Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1. | Toxicology 20040715 |
| FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. | Journal of immunology (Baltimore, Md. : 1950) 20040715 |
| Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists. | Bioorganic & medicinal chemistry letters 20040705 |
| Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. | Journal of leukocyte biology 20040701 |
| The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. | Chemistry and physics of lipids 20040701 |
| Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. | Nature immunology 20040701 |
| Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. | Apoptosis : an international journal on programmed cell death 20040701 |
| FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040701 |
| Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate. | British journal of pharmacology 20040701 |
| FTY720--the first compound of a new promising class of immunosuppressive drugs. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701 |
| FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations. | The British journal of ophthalmology 20040701 |
| Sphingosine signaling and atherogenesis. | Acta pharmacologica Sinica 20040701 |
| Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. | Journal of immunology (Baltimore, Md. : 1950) 20040701 |
| Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. | Journal of magnetic resonance imaging : JMRI 20040701 |
| Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. | Investigative ophthalmology & visual science 20040701 |
| Should we B-leavin' now? | Nature immunology 20040701 |
| Lysophospholipids are potential biomarkers of ovarian cancer. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701 |
| Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | Journal of neurosurgery 20040701 |
| Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | Autonomic & autacoid pharmacology 20040701 |
| FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. | Transplantation 20040627 |
| Effect of FTY720 on rat small bowel transplantation. | Transplantation 20040627 |
| Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. | Bioorganic & medicinal chemistry letters 20040621 |
| The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. | Blood 20040615 |
| Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | The Biochemical journal 20040615 |
| Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. | Cancer research 20040615 |
| A practical synthesis of D-erythro-sphingosine using a cross-metathesis approach. | Organic & biomolecular chemistry 20040607 |
| Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. | The Journal of biological chemistry 20040604 |
| Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | American journal of respiratory cell and molecular biology 20040601 |
| Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. | American journal of respiratory and critical care medicine 20040601 |
| Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601 |
| Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization. | Journal of cellular physiology 20040601 |
| Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. | Journal of thrombosis and haemostasis : JTH 20040601 |
| Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. | The Journal of infectious diseases 20040601 |
| FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040601 |
| The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. | The Plant cell 20040601 |
| Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. | Biochimica et biophysica acta 20040601 |
| Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. | Biochimica et biophysica acta 20040601 |
| Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. | The Journal of investigative dermatology 20040601 |
| Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | Journal of neurochemistry 20040601 |
| Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | Journal of neurochemistry 20040601 |
| Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. | Eukaryotic cell 20040601 |
| Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells. | Journal of biochemistry 20040601 |
| Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. | Journal of pharmacological sciences 20040601 |
| S1P and LPA trigger Schwann cell actin changes and migration. | The European journal of neuroscience 20040601 |
| ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | Journal of UOEH 20040601 |
| Future immunosuppressive agents in solid-organ transplantation. | Progress in transplantation (Aliso Viejo, Calif.) 20040601 |
| Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | Calcified tissue international 20040601 |
| Sphingolipids in inflammation: roles and implications. | Current molecular medicine 20040601 |
| Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. | The Journal of organic chemistry 20040528 |
| Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | Bioorganic & medicinal chemistry letters 20040517 |
| FTY: not just a homely drug. | Transplantation 20040515 |
| FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes. | Transplantation 20040515 |
| Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells. | Biochemical and biophysical research communications 20040507 |
| Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. | The Journal of pharmacology and experimental therapeutics 20040501 |
| DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. | The Biochemical journal 20040501 |
| Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. | The Journal of pharmacology and experimental therapeutics 20040501 |
| Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). | Hypertension (Dallas, Tex. : 1979) 20040501 |
| Immunoregulatory lysophospholipids: new stars in the mast cell constellation. | Current allergy and asthma reports 20040501 |
| Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. | American journal of physiology. Cell physiology 20040501 |
| Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. | American journal of physiology. Cell physiology 20040501 |
| Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. | British journal of clinical pharmacology 20040501 |
| Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. | Journal of clinical pharmacology 20040501 |
| Role of ceramide in ischemic preconditioning. | Journal of the American College of Surgeons 20040501 |
| Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. | Arteriosclerosis, thrombosis, and vascular biology 20040501 |
| An extensive microarray analysis of AAL-toxin-induced cell death in Arabidopsis thaliana brings new insights into the complexity of programmed cell death in plants. | Cellular and molecular life sciences : CMLS 20040501 |
| FTY720 impairs necrosis development after ischemia-reperfusion injury. | Transplantation proceedings 20040501 |
| FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination. | Transplantation proceedings 20040501 |
| Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. | Inflammatory bowel diseases 20040501 |
| Phospholipid mediators and MgATPase modulation causes changes in the cardiovascular effects of vasopressin in lithium carbonate-induced polyuric rats. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | Circulation research 20040430 |
| Straightforward synthesis of sphinganines via a serine-derived Weinreb amide. | The Journal of organic chemistry 20040430 |
| The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions. | The Journal of biological chemistry 20040423 |
| Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. | Blood 20040415 |
| Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii. | Yeast (Chichester, England) 20040415 |
| Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. | European journal of pharmacology 20040405 |
| Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. | The Journal of biological chemistry 20040402 |
| Point-counterpoint of sphingosine 1-phosphate metabolism. | Circulation research 20040402 |
| Cerebrosides of Candida lipolytica yeast. | Applied microbiology and biotechnology 20040401 |
| Novel protein kinase C and matrix metalloproteinase inhibitors of vegetable origin as potential modulators of Langerhans cell migration following hapten-induced sensitization. | International archives of allergy and immunology 20040401 |
| Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | Journal of cellular biochemistry 20040401 |
| Studies on sulfatides by quadrupole ion-trap mass spectrometry with electrospray ionization: structural characterization and the fragmentation processes that include an unusual internal galactose residue loss and the classical charge-remote fragmentation. | Journal of the American Society for Mass Spectrometry 20040401 |
| A lipid transfer protein gene BG-14 is differentially regulated by abiotic stress, ABA, anisomycin, and sphingosine in bromegrass (Bromus inermis). | Journal of plant physiology 20040401 |
| Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. | Mycopathologia 20040401 |
| Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. | Transplantation 20040327 |
| Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | The Journal of biological chemistry 20040326 |
| Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | The Journal of biological chemistry 20040326 |
| Sphingolipids as bioactive regulators of thrombin generation. | The Journal of biological chemistry 20040326 |
| Ceramide-1-phosphate: a novel regulator of cell activation. | FEBS letters 20040326 |
| SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I. | Neurology 20040323 |
| Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2. | Bioorganic & medicinal chemistry letters 20040322 |
| Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. | Blood 20040315 |
| Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. | Biology of reproduction 20040301 |
| Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. | Cellular signalling 20040301 |
| The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301 |
| FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040301 |
| Fluorescence-based assay of sphingosine kinases. | Analytical biochemistry 20040301 |
| FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. | Kidney international 20040301 |
| Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. | Journal of cellular biochemistry 20040301 |
| FTY720: from bench to bedside. | Transplantation proceedings 20040301 |
| FTY720: early clinical experience. | Transplantation proceedings 20040301 |
| FTY720 immunomodulation: optimism for improved transplant regimens. | Transplantation proceedings 20040301 |
| The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat. | Pediatric diabetes 20040301 |
| Inhibition of skin sphingosine synthesis: enhanced percutaneous permeation of 5-fluorouracil. | Die Pharmazie 20040301 |
| Myriocin, a serine palmitoyltransferase inhibitor, alters regional brain neurotransmitter levels without concurrent inhibition of the brain sphingolipid biosynthesis in mice. | Toxicology letters 20040227 |
| Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. | Biochimica et biophysica acta 20040227 |
| Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | European journal of pharmacology 20040220 |
| Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | The Biochemical journal 20040215 |
| Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. | Journal of immunology (Baltimore, Md. : 1950) 20040215 |
| Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS/MS: identification of ceramides containing sphingadienine. | Journal of lipid research 20040201 |
| S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201 |
| Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. | International journal of molecular medicine 20040201 |
| Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | Journal of neurochemistry 20040201 |
| Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production. | Critical care medicine 20040201 |
| Ceramide lances the lungs. | Nature medicine 20040201 |
| Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | Nature 20040122 |
| Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. | European journal of pharmacology 20040119 |
| Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. | FEBS letters 20040116 |
| Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. | Biochemistry 20040113 |
| Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. | The Journal of biological chemistry 20040109 |
| (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells. | Bioorganic & medicinal chemistry 20040102 |
| Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure. | American journal of physiology. Cell physiology 20040101 |
| Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. | Journal of cellular physiology 20040101 |
| Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | Cellular signalling 20040101 |
| Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | Glia 20040101 |
| CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040101 |
| Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | Journal of thrombosis and haemostasis : JTH 20040101 |
| Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. | Arthritis and rheumatism 20040101 |
| Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. | The Journal of surgical research 20040101 |
| Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts. | The Journal of dermatology 20040101 |
| Pharmacologic immunosuppression. | Frontiers in bioscience : a journal and virtual library 20040101 |
| A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. | Glycoconjugate journal 20040101 |
| FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction. | The Annals of pharmacotherapy 20040101 |
| Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. | Prostaglandins & other lipid mediators 20040101 |
| Constitutive expression of the S1P1 receptor in adult tissues. | Prostaglandins & other lipid mediators 20040101 |
| Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101 |
| Down-regulation of Bcl-2 in the fetal brain of the Gaucher disease mouse model: a possible role in the neuronal loss. | Journal of human genetics 20040101 |
| A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. | BMC biochemistry 20040101 |
| Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | Drug news & perspectives 20040101 |
| [Bioeffector sphingolipids as stimulators of cell growth and survival]. | Bioorganicheskaia khimiia 20040101 |
| Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. | Glycoconjugate journal 20040101 |
| Differential regulation of apoptotic cell death in senescent human cells. | Experimental gerontology 20040101 |
| Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | Cells, tissues, organs 20040101 |
| Treatment of focal cerebral ischemia with liposomal nerve growth factor. | Drug delivery 20040101 |
| Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. | Glycoconjugate journal 20040101 |
| Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells. | Molecules and cells 20031231 |
| Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices. | Biochemical and biophysical research communications 20031226 |
| Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. | The Journal of biological chemistry 20031212 |
| Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. | Biochimica et biophysica acta 20031207 |
| Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes. | Pigment cell research 20031201 |
| Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. | Journal of immunology (Baltimore, Md. : 1950) 20031201 |
| Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | Biochemical Society transactions 20031201 |
| Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. | Human reproduction (Oxford, England) 20031201 |
| Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201 |
| Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. | Molecular and cellular biochemistry 20031201 |
| Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. | Neurobiology of disease 20031201 |
| Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins. | Cellular and molecular life sciences : CMLS 20031201 |
| Current immunosuppressive agents: efficacy, side effects, and utilization. | Pediatric clinics of North America 20031201 |
| Ceramide pathways modulate ethanol-induced cell death in astrocytes. | Journal of neurochemistry 20031201 |
| Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. | Journal of enzyme inhibition and medicinal chemistry 20031201 |
| Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. | The Journal of biological chemistry 20031128 |
| Significant prolongation of orthotopic corneal-graft survival in FTY720-treated mice. | Transplantation 20031127 |
| Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. | The Journal of biological chemistry 20031121 |
| Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | The Journal of biological chemistry 20031121 |
| Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. | FEBS letters 20031120 |
| The effects of protein kinase C activity on synaptic transmission in two areas of rat hippocampus. | Brain research 20031114 |
| Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | Brain research 20031114 |
| Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. | Biochemical and biophysical research communications 20031114 |
| The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. | FEBS letters 20031106 |
| Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry. | Journal of lipid research 20031101 |
| Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms. | The Biochemical journal 20031101 |
| Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels. | Biochemical pharmacology 20031101 |
| Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. | Journal of immunology (Baltimore, Md. : 1950) 20031101 |
| Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. | Molecular pharmacology 20031101 |
| Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | Journal of cellular biochemistry 20031101 |
| Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. | The Journal of clinical investigation 20031101 |
| Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. | The Journal of clinical endocrinology and metabolism 20031101 |
| Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. | Journal of biochemistry 20031101 |
| Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. | European journal of cell biology 20031101 |
| Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis. | The Journal of investigative dermatology 20031101 |
| Tetraacetyl phytosphingosine-induced caspase activation and apoptosis occur through G2 arrest in human keratinocyte HaCaT cells. | The Journal of investigative dermatology 20031101 |
| FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model. | Transplantation 20031027 |
| Sphingosine 1-phosphate and cell migration: resistance to angiogenesis inhibitors. | Biochemical and biophysical research communications 20031024 |
| Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | Bioorganic & medicinal chemistry letters 20031020 |
| Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. | Toxicology and applied pharmacology 20031015 |
| Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. | Transplantation 20031015 |
| Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. | The Journal of biological chemistry 20031010 |
| Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. | The Journal of organic chemistry 20031003 |
| Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. | Cellular signalling 20031001 |
| Egress: a receptor-regulated step in lymphocyte trafficking. | Immunological reviews 20031001 |
| Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. | Journal of immunology (Baltimore, Md. : 1950) 20031001 |
| Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031001 |
| Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | Journal of biomolecular screening 20031001 |
| Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids. | Journal of biochemistry 20031001 |
| Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine. | International journal of clinical pharmacology and therapeutics 20031001 |
| [Study the mechanisms and inducing transplantation immune tolerance of FTY720]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001 |
| Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D. | Biochimica et biophysica acta 20030922 |
| Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | The Biochemical journal 20030915 |
| Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. | Regulatory peptides 20030915 |
| Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. | Biochemical and biophysical research communications 20030912 |
| Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | Cancer letters 20030910 |
| Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | The Journal of biological chemistry 20030905 |
| Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. | The Journal of organic chemistry 20030905 |
| Novel, short, stereospecific synthesis of lyxo-(2R,3R,4R)-phytosphingosine and erythro-(2R,3S)-sphingosine. | The Journal of organic chemistry 20030905 |
| Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. | Blood 20030901 |
| Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells. | Journal of lipid research 20030901 |
| Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. | Cell biochemistry and function 20030901 |
| Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. | Nature cell biology 20030901 |
| Enlargement and contracture of C2-ceramide channels. | Biophysical journal 20030901 |
| FTY720, a new immunosuppressant, as rescue therapy in mouse cardiac transplantation. | Acta pharmacologica Sinica 20030901 |
| Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | Cancer research 20030901 |
| Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. | Archives of pharmacal research 20030901 |
| Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | The Journal of biological chemistry 20030829 |
| Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. | The Journal of biological chemistry 20030822 |
| Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | The Journal of biological chemistry 20030815 |
| The reverse activity of human acid ceramidase. | The Journal of biological chemistry 20030808 |
| Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx. | American journal of physiology. Heart and circulatory physiology 20030801 |
| Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | EMBO reports 20030801 |
| Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. | Molecular pharmacology 20030801 |
| Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. | Genes to cells : devoted to molecular & cellular mechanisms 20030801 |
| Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | Diabetes 20030801 |
| Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | Melanoma research 20030801 |
| The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801 |
| Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801 |
| A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCdelta: a preliminary note. | Biochemical and biophysical research communications 20030801 |
| Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | Current opinion in chemical biology 20030801 |
| Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4. | International journal of radiation biology 20030801 |
| Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine. | Journal of medicinal chemistry 20030731 |
| Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. | The Journal of biological chemistry 20030725 |
| Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | The Journal of biological chemistry 20030725 |
| Sphinganine to sphingosine ratio and predictive biochemical markers of fumonisin B1 exposure in ducks. | Chemico-biological interactions 20030725 |
| Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism. | Organic & biomolecular chemistry 20030721 |
| Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. | The Journal of biological chemistry 20030718 |
| Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | The Biochemical journal 20030715 |
| Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. | Archives of biochemistry and biophysics 20030715 |
| Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. | Journal of neuroscience research 20030715 |
| Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. | Biochemical and biophysical research communications 20030711 |
| A facile synthesis of phytosphingosine from diisopropylidene-D-mannofuranose. | The Journal of organic chemistry 20030711 |
| Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | Bioorganic & medicinal chemistry 20030703 |
| Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | American journal of physiology. Lung cellular and molecular physiology 20030701 |
| Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride. | Journal of lipid research 20030701 |
| Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). | Cellular signalling 20030701 |
| High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | Arteriosclerosis, thrombosis, and vascular biology 20030701 |
| Pleiotropic actions of sphingosine-1-phosphate. | Progress in lipid research 20030701 |
| Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030701 |
| FTY720: A new kid on the block for transplant immunosuppression. | Expert opinion on biological therapy 20030701 |
| Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | Experimental hematology 20030701 |
| Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | American heart journal 20030701 |
| Sphingolipids, new players in plant signaling. | Trends in plant science 20030701 |
| A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | Journal of pharmacological sciences 20030701 |
| Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | The Journal of surgical research 20030701 |
| Possible modulators of IL-8 and GRO-alpha production by granulosa cells. | American journal of reproductive immunology (New York, N.Y. : 1989) 20030701 |
| Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach. | Cellular and molecular biology (Noisy-le-Grand, France) 20030701 |
| Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. | Cellular and molecular biology (Noisy-le-Grand, France) 20030701 |
| Functional role of caspases in sphingosine-induced apoptosis in human hepatoma cells. | IUBMB life 20030701 |
| [Sphingolipid and apoptosis]. | Sheng li ke xue jin zhan [Progress in physiology] 20030701 |
| Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | The Journal of biological chemistry 20030627 |
| Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. | Circulation 20030624 |
| Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. | The Journal of biological chemistry 20030620 |
| Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | Blood 20030615 |
| Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. | Experimental cell research 20030610 |
| Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. | Nature 20030605 |
| Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathway. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway. | Fungal genetics and biology : FG & B 20030601 |
| Sphingosine 1-phosphate and control of vascular tone. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings. | Molecular pharmacology 20030601 |
| A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells. | Cell death and differentiation 20030601 |
| Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. | The Journal of urology 20030601 |
| Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | Journal of neurovirology 20030601 |
| Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | British journal of haematology 20030601 |
| Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. | Genes to cells : devoted to molecular & cellular mechanisms 20030601 |
| Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | Atherosclerosis 20030601 |
| The presence of ceramidase activity in liver nuclear membrane. | Biological & pharmaceutical bulletin 20030601 |
| Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism? | Molecular genetics and metabolism 20030601 |
| The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance. | Transplant international : official journal of the European Society for Organ Transplantation 20030601 |
| Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides. | Transplantation proceedings 20030601 |
| S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | European journal of pharmacology 20030523 |
| Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. | Journal of cell science 20030515 |
| Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories. | Statistics in medicine 20030515 |
| Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria. | Bioorganic & medicinal chemistry 20030515 |
| Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | Biochemical pharmacology 20030515 |
| FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells. | Transplantation 20030515 |
| Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. | Toxicology 20030503 |
| The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | The Biochemical journal 20030501 |
| Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. | Journal of cell science 20030501 |
| Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action. | Pharmacological research 20030501 |
| Signaling and biological actions of sphingosine 1-phosphate. | Pharmacological research 20030501 |
| The roles of ceramide and complex sphingolipids in neuronal cell function. | Pharmacological research 20030501 |
| Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. | Pharmacological research 20030501 |
| Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. | Journal of neuroendocrinology 20030501 |
| Sphingosine-1-phosphate: an enigmatic signalling lipid. | Nature reviews. Molecular cell biology 20030501 |
| Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. | Journal of neuropathology and experimental neurology 20030501 |
| Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent. | Peptides 20030501 |
| Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats. | Transplantation 20030427 |
| Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | The Journal of biological chemistry 20030418 |
| Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. | Archives of biochemistry and biophysics 20030415 |
| FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A. | Transplantation 20030415 |
| Antinutritional effects of fumonisin B1 and pathophysiological consequences. | Toxicology letters 20030411 |
| BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. | Science (New York, N.Y.) 20030404 |
| Total syntheses of symbioramide derivatives from l-serine and their antileukemic activities. | The Journal of organic chemistry 20030404 |
| EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | Journal of cell science 20030401 |
| Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | Cellular signalling 20030401 |
| Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | Cellular signalling 20030401 |
| Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells. | Journal of immunology (Baltimore, Md. : 1950) 20030401 |
| New acylceramide in native and reconstructed epidermis. | The Journal of investigative dermatology 20030401 |
| Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | The Journal of investigative dermatology 20030401 |
| Paradoxical effects of sphingosine-1-phosphate. | The Journal of investigative dermatology 20030401 |
| Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. | The Journal of pharmacology and experimental therapeutics 20030401 |
| Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | Cardiovascular research 20030401 |
| Sphingoid bases as possible diagnostic parameters. | Croatian medical journal 20030401 |
| A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. | British journal of pharmacology 20030401 |
| The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice. | Clinical immunology (Orlando, Fla.) 20030401 |
| Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. | Cellular and molecular life sciences : CMLS 20030401 |
| High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. | Molecular and cellular biochemistry 20030401 |
| Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | FEBS letters 20030327 |
| Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers. | The Journal of organic chemistry 20030321 |
| Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | The Biochemical journal 20030315 |
| Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | Journal of immunology (Baltimore, Md. : 1950) 20030315 |
| Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | The Journal of biological chemistry 20030314 |
| Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis. | The Journal of biological chemistry 20030314 |
| Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic. | The Journal of biological chemistry 20030314 |
| Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. | Science (New York, N.Y.) 20030314 |
| S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. | Journal of applied physiology (Bethesda, Md. : 1985) 20030301 |
| Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030301 |
| Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | Journal of cellular biochemistry 20030301 |
| Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | Prostaglandins, leukotrienes, and essential fatty acids 20030301 |
| Myoclonic epilepsy in Gaucher disease: genotype-phenotype insights from a rare patient subgroup. | Pediatric research 20030301 |
| Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. | Diabetes 20030301 |
| Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. | Molecular pharmacology 20030301 |
| Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. | Epilepsia 20030301 |
| FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | The Journal of clinical investigation 20030301 |
| Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. | The Journal of clinical investigation 20030301 |
| Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. | Pflugers Archiv : European journal of physiology 20030301 |
| Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis. | Laboratory investigation; a journal of technical methods and pathology 20030301 |
| [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030301 |
| Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. | Molecular and cellular neurosciences 20030301 |
| Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720. | Bioscience, biotechnology, and biochemistry 20030301 |
| Ceramide mediates growth inhibition of the Plasmodium falciparum parasite. | Cellular and molecular life sciences : CMLS 20030301 |
| Sphingosine 1-phosphate signal transduction in muscle cells. | The Italian journal of biochemistry 20030301 |
| Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. | Cancer letters 20030227 |
| Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells. | Bioorganic & medicinal chemistry letters 20030224 |
| Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | Bioorganic & medicinal chemistry letters 20030224 |
| Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. | The Journal of biological chemistry 20030221 |
| Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. | The Journal of biological chemistry 20030221 |
| Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | The Biochemical journal 20030215 |
| Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. | Biochemical and biophysical research communications 20030207 |
| Structure-function relations in self-assembled C18- and C20-sphingosines monolayers at gas/water interfaces. | Journal of the American Chemical Society 20030205 |
| Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. | Biochemical pharmacology 20030201 |
| Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. | Molecular pharmacology 20030201 |
| Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation. | Cell calcium 20030201 |
| Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. | Gastroenterology 20030201 |
| Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | Journal of neurochemistry 20030201 |
| Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. | British journal of pharmacology 20030201 |
| Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201 |
| Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030201 |
| [Effects of three different immunosuppressive drugs on SD rat islet cell viability]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030201 |
| CTLA4Ig-gene transfection with FTY720 administration markedly inhibits the obliterative airway disease in heterotopically transplanted rat tracheas. | Transplantation proceedings 20030201 |
| Pretreatment with FTY720 alone induced long-term survival of mouse heart allograft. | Transplantation proceedings 20030201 |
| A novel role for sphingolipid intermediates in activation-induced cell death in T cells. | Cell death and differentiation 20030201 |
| Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells. | Cell death and differentiation 20030201 |
| Sphingosine-1-phosphate stimulates cortisol secretion. | FEBS letters 20030130 |
| First asymmetric synthesis of 6-hydroxy-4-sphingenine-containing ceramides. Use of chiral propargylic alcohols to prepare a lipid found in human skin. | The Journal of organic chemistry 20030124 |
| Synthesis and growth inhibitory activity of chiral 5-hydroxy-2-N-acyl-(3E)-sphingenines: ceramides with an unusual sphingoid backbone. | The Journal of organic chemistry 20030124 |
| Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. | Biochemistry 20030121 |
| Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | Bioorganic & medicinal chemistry letters 20030120 |
| Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | The Biochemical journal 20030115 |
| Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. | Glia 20030115 |
| Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | Biochemical and biophysical research communications 20030110 |
| Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. | FEBS letters 20030102 |
| Analysis of ceramides in cosmetics by reversed-phase liquid chromatography/electrospray ionization mass spectrometry with collision-induced dissociation. | Rapid communications in mass spectrometry : RCM 20030101 |
| Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | Endocrinology 20030101 |
| Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. | European journal of biochemistry 20030101 |
| Linking Chinese medicine and G-protein-coupled receptors. | Trends in pharmacological sciences 20030101 |
| Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. | Journal of lipid research 20030101 |
| Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. | British journal of pharmacology 20030101 |
| Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030101 |
| Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20030101 |
| Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. | Archives of dermatological research 20030101 |
| Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | Cancer treatment and research 20030101 |
| Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20030101 |
| Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101 |
| [The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ]. | Bioorganicheskaia khimiia 20030101 |
| C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. | Neuroscience 20030101 |
| [Progress in the study of physiological function of sphingosine 1-phosphate]. | Sheng li ke xue jin zhan [Progress in physiology] 20030101 |
| C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. | Journal of endotoxin research 20030101 |
| Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction. | Journal of vascular research 20030101 |
| Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. | Anticancer research 20030101 |
| Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase. | Biology of the neonate 20030101 |
| Sphingosine-1-phosphate signaling in endothelial activation. | Journal of atherosclerosis and thrombosis 20030101 |
| Renal transplantation: basic concepts and evolution of therapy. | Journal of clinical apheresis 20030101 |
| New paradigms in immunosuppression. | CANNT journal = Journal ACITN 20030101 |
| [Sphingolipid-mediated apoptotic signaling pathways]. | Journal de la Societe de biologie 20030101 |
| Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle. | Journal of muscle research and cell motility 20030101 |
| Different mechanisms for membrane and nuclear damages in apoptosis induced by an immunosuppressant, FTY720. | Molecules and cells 20021231 |
| Sphingosine in apoptosis signaling. | Biochimica et biophysica acta 20021230 |
| Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. | Biochimica et biophysica acta 20021230 |
| Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | Biochimica et biophysica acta 20021230 |
| Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice. | Transplantation 20021227 |
| Gangliosides activate Trk receptors by inducing the release of neurotrophins. | The Journal of biological chemistry 20021220 |
| Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. | Toxicology and applied pharmacology 20021215 |
| Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | Biochemical and biophysical research communications 20021206 |
| Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK. | Cellular signalling 20021201 |
| Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | Cellular signalling 20021201 |
| Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis. | Current microbiology 20021201 |
| Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticillioides (=F. moniliforme) culture material containing fumonisins. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201 |
| T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2. | British journal of pharmacology 20021201 |
| Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | Journal of immunology (Baltimore, Md. : 1950) 20021201 |
| The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | Endocrinology 20021201 |
| Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201 |
| Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021201 |
| Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | Arteriosclerosis, thrombosis, and vascular biology 20021201 |
| Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | Genes to cells : devoted to molecular & cellular mechanisms 20021201 |
| Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | Archives of biochemistry and biophysics 20021201 |
| Cis-4-methylsphingosine phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK mitogen-activated protein kinases. | Biological chemistry 20021201 |
| Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. | Gene expression patterns : GEP 20021201 |
| Sphingosine modulation of cAMP levels and beating rate in rat heart. | Fundamental & clinical pharmacology 20021201 |
| Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | Biochemical and biophysical research communications 20021129 |
| Efficacy of mycophenolate sodium as monotherapy and in combination with FTY720 in a DA-to-Lewis-rat heart-transplantation model. | Transplantation 20021127 |
| Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115 |
| Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. | Brain research 20021115 |
| Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. | Circulation research 20021115 |
| Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | Experimental cell research 20021115 |
| Comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthalaldehyde fluorogenic reagents for chromatographic detection of sphingoid bases. | Journal of chromatography. A 20021115 |
| Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). | The Journal of biological chemistry 20021108 |
| Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells. | The Biochemical journal 20021101 |
| C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. | Cellular signalling 20021101 |
| Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. | Cellular signalling 20021101 |
| Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action. | American journal of physiology. Cell physiology 20021101 |
| Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis. | Molecular pharmacology 20021101 |
| Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | Archives of biochemistry and biophysics 20021101 |
| An experimental approach for direct observation of the interaction of polyanions with sphingosine-containing giant vesicles. | Bioelectrochemistry (Amsterdam, Netherlands) 20021101 |
| Glucosylceramide modulates membrane traffic along the endocytic pathway. | Journal of lipid research 20021101 |
| Increased biosynthesis of glycosphingolipids in congenital disorder of glycosylation Ia (CDG-Ia) fibroblasts. | Pediatric research 20021101 |
| Role of protein kinase C alpha in primary human osteoblast proliferation. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101 |
| A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | Trends in plant science 20021101 |
| Sirolimus and FTY720: new approaches to transplant immunosuppression. | Transplantation proceedings 20021101 |
| Effects of mycophenolate sodium with or without FTY720 in a DA-to-Lewis rat heart transplantation model. | Transplantation proceedings 20021101 |
| Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | The Journal of surgical research 20021101 |
| New sphingosines from the marine sponge Grayella cyatophora. | Journal of natural products 20021101 |
| Prolactin signaling in porcine adrenocortical cells: involvement of protein kinases. | Domestic animal endocrinology 20021101 |
| Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis. | Annals of the New York Academy of Sciences 20021101 |
| [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| Cellular regulation of sodium-calcium exchange. | Annals of the New York Academy of Sciences 20021101 |
| Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | Thrombosis research 20021101 |
| Sphingosine-1-phosphate: dual messenger functions. | FEBS letters 20021030 |
| Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. | Biochemical pharmacology 20021015 |
| Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | Journal of immunology (Baltimore, Md. : 1950) 20021015 |
| Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. | Transplantation 20021015 |
| Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. | Journal of medicinal chemistry 20021010 |
| Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. | The Journal of biological chemistry 20021004 |
| Transplantation. | Current opinion in immunology 20021001 |
| FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. | Current opinion in immunology 20021001 |
| D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | Atherosclerosis 20021001 |
| Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | Apoptosis : an international journal on programmed cell death 20021001 |
| Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent. | American journal of physiology. Gastrointestinal and liver physiology 20021001 |
| Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology. | Current opinion in lipidology 20021001 |
| Effects of C2-ceramide on the Malme-3M melanoma cell line. | Journal of dermatological science 20021001 |
| Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes. | Investigative ophthalmology & visual science 20021001 |
| FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20021001 |
| Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp. | Journal of natural products 20021001 |
| Identification of platelet-activating factor acetylhydrolase II in human skin. | The Journal of investigative dermatology 20021001 |
| Apoptosis induction by wheat-flour sphingoid bases in DLD-1 human colon cancer cells. | Bioscience, biotechnology, and biochemistry 20021001 |
| Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. | The Journal of biological chemistry 20020927 |
| Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. | The Journal of biological chemistry 20020927 |
| Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | Biochemical and biophysical research communications 20020927 |
| PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | The Journal of biological chemistry 20020920 |
| Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. | Neuroscience letters 20020920 |
| Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base. | Archives of biochemistry and biophysics 20020915 |
| Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat. | Transplantation 20020915 |
| Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. | Life sciences 20020913 |
| A role for the de novo sphingolipids in apoptosis of photosensitized cells. | Experimental cell research 20020910 |
| Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | Cellular signalling 20020901 |
| Phosphorylation of cardiac protein kinase B is regulated by palmitate. | American journal of physiology. Heart and circulatory physiology 20020901 |
| Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. | Molecular pharmacology 20020901 |
| Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. | Hepatology (Baltimore, Md.) 20020901 |
| Sphingosine 1-phosphate as a therapeutic agent. | Leukemia 20020901 |
| Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. | Nature medicine 20020901 |
| The roles of sphingosine-1-phosphate in asthma. | Molecular immunology 20020901 |
| FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients. | Transplantation proceedings 20020901 |
| Serum factors involved in human microvascular endothelial cell morphogenesis. | The Journal of laboratory and clinical medicine 20020901 |
| Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020901 |
| Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | Cellular immunology 20020901 |
| Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression. | The Journal of biological chemistry 20020823 |
| Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. | Bioorganic & medicinal chemistry letters 20020819 |
| Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. | The Journal of biological chemistry 20020816 |
| Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | The Biochemical journal 20020815 |
| Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | World journal of gastroenterology 20020815 |
| Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells. | Molecular pharmacology 20020801 |
| Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | Gastroenterology 20020801 |
| Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | Journal of neurochemistry 20020801 |
| Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction. | British journal of pharmacology 20020801 |
| Effect of thalidomide on the skeletal muscle in experimental heart failure. | European journal of heart failure 20020801 |
| Combined therapy of CTLA4Ig-gene transfection with FTY720 administration in rat lung allografts. | Transplantation proceedings 20020801 |
| FTY720: a novel approach to the treatment of hepatic ischemia-reperfusion injury. | Transplantation proceedings 20020801 |
| Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. | The Journal of investigative dermatology 20020801 |
| Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype. | Molecular genetics and metabolism 20020801 |
| Sphingosine-based liposome as DNA vector for intramuscular gene delivery. | Pharmaceutical research 20020801 |
| The role of H2O2 in the platelet-derived growth factor-induced transcription of the gamma-glutamylcysteine synthetase heavy subunit. | Cellular and molecular life sciences : CMLS 20020801 |
| Sphingosine-induced c-jun expression: differences between sphingosine- and C2-ceramide-mediated signaling pathways. | FEBS letters 20020731 |
| Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | The Journal of biological chemistry 20020726 |
| New roads leading to Ca2+ sensitization. | Circulation research 20020726 |
| Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. | Circulation research 20020726 |
| Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. | Circulation research 20020726 |
| A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine. | Cancer letters 20020726 |
| Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | Cancer letters 20020726 |
| Sphingosine 1-phosphate, a key cell signaling molecule. | The Journal of biological chemistry 20020719 |
| Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. | Cellular signalling 20020701 |
| Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | The Biochemical journal 20020701 |
| Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | The Journal of laboratory and clinical medicine 20020701 |
| N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701 |
| Ethanol-induced increase of sphingosine recycling for ganglioside biosynthesis: a study performed on cerebellar granule cells in culture. | Journal of neuroscience research 20020701 |
| Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. | European journal of immunology 20020701 |
| Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1. | Structure (London, England : 1993) 20020701 |
| Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. | The Journal of biological chemistry 20020628 |
| A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | Biochemical and biophysical research communications 20020628 |
| Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | Biochemical and biophysical research communications 20020628 |
| A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | FEBS letters 20020619 |
| Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. | Journal of cell science 20020615 |
| Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood. | The Journal of biological chemistry 20020614 |
| The immune modulator FTY720 targets sphingosine 1-phosphate receptors. | The Journal of biological chemistry 20020614 |
| Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. | Cellular signalling 20020601 |
| Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. | American journal of physiology. Cell physiology 20020601 |
| Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. | Toxicological sciences : an official journal of the Society of Toxicology 20020601 |
| Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase. | Cell death and differentiation 20020601 |
| The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. | Journal of biochemistry 20020601 |
| Structural studies on ceramides as lithiated adducts by low energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization. | Journal of the American Society for Mass Spectrometry 20020601 |
| Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020601 |
| Cytotoxic sphingosine 4-sulfates from the sponge Spirastrella abata. | Journal of natural products 20020601 |
| Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | Journal of biosciences 20020601 |
| Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. | Biological chemistry 20020601 |
| Sphingosine-1-phosphate and lipid phosphohydrolases. | Biochimica et biophysica acta 20020523 |
| Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | Biochimica et biophysica acta 20020523 |
| Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. | Biochimica et biophysica acta 20020523 |
| Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | Biochimica et biophysica acta 20020523 |
| Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | Biochimica et biophysica acta 20020523 |
| Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | Biochimica et biophysica acta 20020523 |
| Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | Biochimica et biophysica acta 20020523 |
| Sphingosylphosphorylcholine-biological functions and mechanisms of action. | Biochimica et biophysica acta 20020523 |
| Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. | Biochimica et biophysica acta 20020523 |
| Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate. | Biochimica et biophysica acta 20020523 |
| Lysophospholipids and the cardiovascular system. | Biochimica et biophysica acta 20020523 |
| Lipid mediators of angiogenesis and the signalling pathways they initiate. | Biochimica et biophysica acta 20020523 |
| Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation. | The Journal of biological chemistry 20020517 |
| Synthesis of D-erythro-dihydrosphingosine and D-xylo-phytosphingosine from a serine-derived 1,5-dioxaspiro[3.2]hexane template. | Organic letters 20020516 |
| Role of sphingosine synthesis inhibition in transcutaneous delivery of levodopa. | International journal of pharmaceutics 20020515 |
| Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720. | Transplantation 20020515 |
| Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin. | Archives of insect biochemistry and physiology 20020501 |
| HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. | American journal of physiology. Gastrointestinal and liver physiology 20020501 |
| Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Cell type-specific localization of human cardiac S1P receptors. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020501 |
| 3-O-acetyl-sphingosine-series myelin glycolipids: characterization of novel 3-O-acetyl-sphingosine galactosylceramide. | Journal of lipid research 20020501 |
| Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells. | Experimental biology and medicine (Maywood, N.J.) 20020501 |
| Characterization of ceramides by low energy collisional-activated dissociation tandem mass spectrometry with negative-ion electrospray ionization. | Journal of the American Society for Mass Spectrometry 20020501 |
| Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy. | Transplantation proceedings 20020501 |
| Donor pretreatment with FTY720 increases graft lymphocytes but does not affect graft survival following rat small bowel transplantation. | Transplantation proceedings 20020501 |
| Dihydroceramide desaturase activity in tumors. | Biochemistry. Biokhimiia 20020501 |
| Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | Trends in cell biology 20020501 |
| Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. | Pharmacology & toxicology 20020501 |
| Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | Journal of neuroscience research 20020501 |
| Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-alpha, and sphingosine. | Circulation research 20020419 |
| Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | Analytical biochemistry 20020415 |
| Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. | Biochemical pharmacology 20020415 |
| Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. | The Journal of biological chemistry 20020412 |
| Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | Science (New York, N.Y.) 20020412 |
| Membrane restructuring via ceramide results in enhanced solute efflux. | The Journal of biological chemistry 20020405 |
| Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. | Neurochemistry international 20020401 |
| Sphingosine kinase inhibitors in the apoptosis of leukaemia cells. | Leukemia research 20020401 |
| Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. | Cellular signalling 20020401 |
| Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | Current opinion in cell biology 20020401 |
| Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. | Experimental cell research 20020401 |
| First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. | Journal of the American Society of Nephrology : JASN 20020401 |
| Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy. | Biophysical journal 20020401 |
| Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020401 |
| Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020401 |
| Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus. | The Journal of rheumatology 20020401 |
| Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. | In vitro cellular & developmental biology. Animal 20020401 |
| Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | The Journal of biological chemistry 20020322 |
| Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. | The Journal of biological chemistry 20020322 |
| Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | FEBS letters 20020313 |
| Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. | International journal of cancer 20020310 |
| Synthesis of D-erythro-sphingosine and D-erythro-ceramide. | Chemical communications (Cambridge, England) 20020307 |
| Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. | Leukemia research 20020301 |
| Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. | The Biochemical journal 20020301 |
| Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. | Molecular pharmacology 20020301 |
| Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. | Molecular pharmacology 20020301 |
| Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells). | The Journal of pharmacology and experimental therapeutics 20020301 |
| A thematic series on lipid signaling: prologue. | Journal of biochemistry 20020301 |
| C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. | Diabetes 20020301 |
| Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | Teratology 20020301 |
| Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | Experimental hematology 20020301 |
| Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. | Cancer research 20020301 |
| [Sphingosine 1-phosphate in yeast]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Signal transduction of ceramide]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Sphingosine 1-phosphate and vascular endothelial cells]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Molecular diversity of sphingosine kinase]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| [Chemical syntheses of sphingophospholipids and their analogues]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301 |
| Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | The Journal of biological chemistry 20020222 |
| Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. | Circulation research 20020222 |
| L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. | Journal of immunology (Baltimore, Md. : 1950) 20020215 |
| Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine. | The Biochemical journal 20020215 |
| Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes. | The Biochemical journal 20020215 |
| Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. | Blood 20020215 |
| Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense. | Genes & development 20020215 |
| Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. | The Journal of biological chemistry 20020201 |
| Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor. | The Biochemical journal 20020201 |
| Update on pharmacokinetic/pharmacodynamic studies with FTY720 and sirolimus. | Therapeutic drug monitoring 20020201 |
| Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity. | Current microbiology 20020201 |
| mAChRs in the grasshopper brain mediate excitation by activation of the AC/PKA and the PLC second-messenger pathways. | Journal of neurophysiology 20020201 |
| Sphingolipids and the regulation of the immune response. | Seminars in immunology 20020201 |
| Factors controlling smooth muscle proliferation and airway remodelling. | Current opinion in allergy and clinical immunology 20020201 |
| Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. | Oncogene 20020131 |
| 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase. | Biochimica et biophysica acta 20020130 |
| What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation? | Transplantation 20020127 |
| Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. | Oncogene 20020103 |
| Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia. | Journal of cardiovascular pharmacology 20020101 |
| Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. | Cellular signalling 20020101 |
| TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones. | Neuropharmacology 20020101 |
| Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | Endocrinology 20020101 |
| Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. | Arteriosclerosis, thrombosis, and vascular biology 20020101 |
| Substrate specificity of rat brain ceramidase. | Journal of lipid research 20020101 |
| Transient relaxation of rat mesenteric microvessels by ceramides. | British journal of pharmacology 20020101 |
| Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival. | Journal of cellular biochemistry 20020101 |
| Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? | The oncologist 20020101 |
| [Biologically effective sphingolipids devoid of 4-trans-double bond in the sphingoid hydrocarbon chain]. | Bioorganicheskaia khimiia 20020101 |
| Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. | Anti-cancer drugs 20020101 |
| Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica. | Journal of basic microbiology 20020101 |
| Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. | Neuroscience 20020101 |
| Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells. | Molecular and cellular biochemistry 20020101 |
| Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis. | Sub-cellular biochemistry 20020101 |
| Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides). | Cancer detection and prevention 20020101 |
| Sphingosine kinases: a novel family of lipid kinases. | Progress in nucleic acid research and molecular biology 20020101 |
| [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20020101 |
| High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | Journal of cellular biochemistry 20020101 |
| Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | Advances in enzyme regulation 20020101 |
| Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. | Genome biology 20020101 |
| Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. | The Journal of eukaryotic microbiology 20020101 |
| In vitro activity of phytosphingosines against Malassezia furfur and Candida albicans. | Acta dermato-venereologica 20020101 |
| Deregulated activation of matriptase in breast cancer cells. | Clinical & experimental metastasis 20020101 |
| Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | Cell calcium 20020101 |
| Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | Cellular and molecular biology (Noisy-le-Grand, France) 20020101 |
| Phosphatidic acid is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by sphingosine, linked to phospholipase C and associated with the nuclear envelope. | Biochimica et biophysica acta 20011230 |
| A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. | The Journal of biological chemistry 20011228 |
| Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. | The Journal of biological chemistry 20011228 |
| A point mutant of human sphingosine kinase 1 with increased catalytic activity. | FEBS letters 20011207 |
| Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | FEBS letters 20011207 |
| Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. | The EMBO journal 20011203 |
| The IL-15R alpha chain signals through association with Syk in human B cells. | Journal of immunology (Baltimore, Md. : 1950) 20011201 |
| Selective ligands for lysophosphatidic acid receptor subtypes: gaining control over the endothelial differentiation gene family. | Molecular pharmacology 20011201 |
| EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201 |
| A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. | The Journal of physiology 20011201 |
| Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway. | Journal of cell science 20011201 |
| Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm. | Stroke 20011201 |
| Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. | American journal of reproductive immunology (New York, N.Y. : 1989) 20011201 |
| [Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201 |
| Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells. | Current genetics 20011201 |
| Sphingolipids in mammalian cell signalling. | Cellular and molecular life sciences : CMLS 20011201 |
| Exogenous sphingosine enters Xenopus laevis embryos grown in petri dishes and it is metabolized. | Bioscience reports 20011201 |
| Lysophospholipids--receptor revelations. | Science (New York, N.Y.) 20011130 |
| Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. | Biochemistry 20011120 |
| High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. | Analytical biochemistry 20011115 |
| Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. | The Journal of biological chemistry 20011102 |
| Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases. | Cellular signalling 20011101 |
| Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | Blood 20011101 |
| A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011101 |
| The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. | Biochemical Society transactions 20011101 |
| 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | The Journal of investigative dermatology 20011101 |
| Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china. | Cancer causes & control : CCC 20011101 |
| Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. | Plant & cell physiology 20011101 |
| [Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer]. | Wei sheng yan jiu = Journal of hygiene research 20011101 |
| Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine. | FEBS letters 20011026 |
| Human and rat alveolar macrophages express multiple EDG receptors. | European journal of pharmacology 20011019 |
| Sphingosine-induced apoptosis is dependent on lysosomal proteases. | The Biochemical journal 20011015 |
| TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. | Experimental cell research 20011015 |
| Fumonisin B(1) induces apoptosis in LLC-PK(1) renal epithelial cells via a sphinganine- and calmodulin-dependent pathway. | Toxicology and applied pharmacology 20011015 |
| Nitric oxide production in living neurons is modulated by sphingosine: a fluorescence microscopy study. | FEBS letters 20011012 |
| Cytoskeleton elements mediate the inhibition of the (Na++K+)atpase activity by PKC in Rhodnius prolixus malpighian tubules during hyperosmotic shock. | Archives of insect biochemistry and physiology 20011001 |
| Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes. | Journal of lipid research 20011001 |
| Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine. | Journal of molecular and cellular cardiology 20011001 |
| Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat. | International immunopharmacology 20011001 |
| Cellular location of (2R, 3R, 7Z)-2-aminotetradec-7-ene-1, 3-diol, a potent antimicrobial metabolite produced by the Caribbean sponge Haliclona vansoesti. | Cell and tissue research 20011001 |
| Neurobiology of the Edg2 lysophosphatidic acid receptor. | Japanese journal of pharmacology 20011001 |
| Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. | The Journal of biological chemistry 20010928 |
| Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. | Neuroscience letters 20010928 |
| Structural requirements of sphingosine molecules for inhibition of DNA primase: biochemical and computational analyses. | Biochemistry 20010925 |
| Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | The Journal of biological chemistry 20010921 |
| Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. | The Journal of biological chemistry 20010921 |
| Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. | The Journal of biological chemistry 20010921 |
| Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. | Biochemistry 20010918 |
| Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. | Cancer research 20010915 |
| FTY720: altered lymphocyte traffic results in allograft protection. | Transplantation 20010915 |
| Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. | The Journal of biological chemistry 20010914 |
| Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | Circulation research 20010914 |
| Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | Circulation research 20010914 |
| Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. | The Journal of biological chemistry 20010907 |
| Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. | Biochemical and biophysical research communications 20010907 |
| Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. | The Journal of clinical investigation 20010901 |
| EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. | Journal of molecular and cellular cardiology 20010901 |
| The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | Journal of molecular and cellular cardiology 20010901 |
| Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | Trends in biochemical sciences 20010901 |
| The induction and persistence of altered sphingolipid biosynthesis in rats treated with fumonisin B1. | Food additives and contaminants 20010901 |
| Immunoseparation of sphingolipid-enriched membrane domains enriched in Src family protein tyrosine kinases and in the neuronal adhesion molecule TAG-1 by anti-GD3 ganglioside monoclonal antibody. | Journal of neurochemistry 20010901 |
| Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | Development (Cambridge, England) 20010901 |
| [mTOR and FTY 720 inhibitors]. | Presse medicale (Paris, France : 1983) 20010901 |
| [What is new on transplantation in 2001?]. | Presse medicale (Paris, France : 1983) 20010901 |
| Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | Molecular cell 20010901 |
| Potential application of plant lipid transfer proteins for drug delivery. | Biochemical pharmacology 20010901 |
| Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irradiation. | Biochemistry. Biokhimiia 20010901 |
| Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | Prostaglandins, leukotrienes, and essential fatty acids 20010901 |
| Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | Biochemical and biophysical research communications 20010831 |
| Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice. | Toxicology 20010828 |
| Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | The Journal of biological chemistry 20010824 |
| Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines. | FEBS letters 20010817 |
| Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase. | Biochemistry 20010814 |
| Nuclear translocation of extracellular signal-regulated kinases in neuronal excitotoxicity. | Neuroreport 20010808 |
| Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. | The Journal of biological chemistry 20010803 |
| Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs. | Journal of immunological methods 20010801 |
| Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. | Journal of cellular physiology 20010801 |
| Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. | Cellular signalling 20010801 |
| Propagation of the apoptotic signal by mitochondrial waves. | The EMBO journal 20010801 |
| Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. | Journal of lipid research 20010801 |
| Preparation of deacetyl-, lyso-, and deacetyl-lyso-GM(3) by selective alkaline hydrolysis of GM3 ganglioside. | Journal of lipid research 20010801 |
| Characterization of novel structures of mannosylinositolphosphorylceramides from the yeast forms of Sporothrix schenckii. | European journal of biochemistry 20010801 |
| Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios. | Journal of agricultural and food chemistry 20010801 |
| Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | Naunyn-Schmiedeberg's archives of pharmacology 20010801 |
| Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | The Journal of biological chemistry 20010727 |
| Immunology. The push-me pull-you of T cell activation. | Science (New York, N.Y.) 20010727 |
| Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. | Science (New York, N.Y.) 20010727 |
| Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum. | The Journal of biological chemistry 20010720 |
| A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. | Analytical biochemistry 20010715 |
| Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model. | Transplantation 20010715 |
| Intracellular signalling: sphingosine-1-phosphate branches out. | Current biology : CB 20010710 |
| The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys. | Toxicon : official journal of the International Society on Toxinology 20010701 |
| Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | Current microbiology 20010701 |
| Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. | Blood 20010701 |
| TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | Journal of immunology (Baltimore, Md. : 1950) 20010701 |
| N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. | Cancer research 20010701 |
| Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. | Toxicology and applied pharmacology 20010701 |
| Occupational acute lung injury due to Alternaria alternata: early stage of organic dust toxic syndrome requires no corticosteroids. | Intensive care medicine 20010701 |
| Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. | Biochimica et biophysica acta 20010629 |
| Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro. | The Journal of biological chemistry 20010615 |
| Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. | FEBS letters 20010615 |
| Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. | Brain research 20010608 |
| Angiostatin effects on endothelial cells mediated by ceramide and RhoA. | EMBO reports 20010606 |
| Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | The Journal of biological chemistry 20010601 |
| A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor. | The Journal of pharmacology and experimental therapeutics 20010601 |
| Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. | Archives of biochemistry and biophysics 20010601 |
| C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. | The EMBO journal 20010601 |
| The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. | The EMBO journal 20010601 |
| Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. | American journal of respiratory cell and molecular biology 20010601 |
| Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. | The European journal of neuroscience 20010601 |
| Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | The European journal of neuroscience 20010601 |
| Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720. | Japanese journal of cancer research : Gann 20010601 |
| The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog. | Chemistry and physics of lipids 20010601 |
| Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | The European journal of neuroscience 20010601 |
| Regulatory mechanisms of female germ cell apoptosis during embryonic development. | Endocrine journal 20010601 |
| C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. | Cell death and differentiation 20010601 |
| Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks. | Toxicology 20010528 |
| Effects of ceramide on aggrecanase activity in rabbit articular cartilage. | Biochemical and biophysical research communications 20010525 |
| Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. | Molecular and cellular endocrinology 20010525 |
| Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. | The Journal of biological chemistry 20010518 |
| Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. | The EMBO journal 20010515 |
| YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. | Cellular microbiology 20010501 |
| The effect of a single gavage dose of fumonisin B(2) on the sphinganine and sphingosine concentrations in vervet monkeys. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501 |
| Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin-contaminated diets. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501 |
| Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. | Journal of immunology (Baltimore, Md. : 1950) 20010501 |
| Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. | Gynecologic oncology 20010501 |
| Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501 |
| Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis. | Journal of the American College of Cardiology 20010501 |
| Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. | Environmental health perspectives 20010501 |
| Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. | Environmental health perspectives 20010501 |
| Analysis of fumonisin B1-induced apoptosis. | Environmental health perspectives 20010501 |
| Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count. | Transplantation proceedings 20010501 |
| FTY-720 is efficacious in monkey kidney transplantation. | Transplantation proceedings 20010501 |
| Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton. | Immunobiology 20010501 |
| Sphinganine in sphingomyelins of tumors and mouse regenerating liver. | Biochemistry. Biokhimiia 20010501 |
| S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus. | The Journal of antibiotics 20010501 |
| Fluorescent staining of subcellular organelles: ER, Golgi complex, and mitochondria. | Current protocols in cell biology 20010501 |
| Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. | Circulation research 20010427 |
| Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. | Life sciences 20010427 |
| High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. | Journal of chromatography. B, Biomedical sciences and applications 20010425 |
| Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. | Biochemistry 20010424 |
| G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | The Journal of biological chemistry 20010420 |
| Basic fibroblast growth factor-induced proliferation of primary astrocytes. evidence for the involvement of sphingomyelin biosynthesis. | The Journal of biological chemistry 20010420 |
| Functional identification of a delta8-sphingolipid desaturase from Borago officinalis. | Archives of biochemistry and biophysics 20010415 |
| Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | The Journal of biological chemistry 20010413 |
| Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | The Journal of biological chemistry 20010413 |
| Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | The Journal of biological chemistry 20010413 |
| Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. | The Journal of biological chemistry 20010406 |
| Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana. | FEBS letters 20010406 |
| Fumonisin B(1) increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves. | Toxicological sciences : an official journal of the Society of Toxicology 20010401 |
| Fumonisin B(1) is hepatotoxic and nephrotoxic in milk-fed calves. | Toxicological sciences : an official journal of the Society of Toxicology 20010401 |
| Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. | The Biochemical journal 20010401 |
| Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. | Toxicology and applied pharmacology 20010401 |
| Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. | Cardiovascular research 20010401 |
| Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010401 |
| Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. | Pigment cell research 20010401 |
| Sphingosine 1-phosphate: synthesis and release. | Prostaglandins & other lipid mediators 20010401 |
| Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. | Prostaglandins & other lipid mediators 20010401 |
| Sphingosine kinase: a mediator of vital cellular functions. | Prostaglandins & other lipid mediators 20010401 |
| Sphingosine 1-phosphate receptors. | Prostaglandins & other lipid mediators 20010401 |
| Sphingosine-1-phosphate phosphatases. | Prostaglandins & other lipid mediators 20010401 |
| Structure activity relationships of lysophospholipid mediators. | Prostaglandins & other lipid mediators 20010401 |
| Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | Prostaglandins & other lipid mediators 20010401 |
| Differential effects of fumonisin B1 on cell death in cultured cells: the significance of the elevated sphinganine. | Archives of pharmacal research 20010401 |
| Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment. | World journal of surgery 20010401 |
| Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | Nature 20010329 |
| Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | Oncogene 20010326 |
| A short and practical route to 3-O-benzoyl azidosphingosine. | Carbohydrate research 20010309 |
| Targeting ceramide metabolism--a strategy for overcoming drug resistance. | Journal of the National Cancer Institute 20010307 |
| Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | Science (New York, N.Y.) 20010302 |
| Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. | European journal of pharmacology 20010302 |
| Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. | Cytometry 20010301 |
| Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. | The Biochemical journal 20010301 |
| Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. | Molecular pharmacology 20010301 |
| NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. | Free radical biology & medicine 20010301 |
| New immunosuppressive drugs: an update. | Current opinion in urology 20010301 |
| Glycoinositolphosphosphingolipids (basidiolipids) of higher mushrooms. | European journal of biochemistry 20010301 |
| Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | Journal of neurochemistry 20010301 |
| Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. | Naunyn-Schmiedeberg's archives of pharmacology 20010301 |
| An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. | Naunyn-Schmiedeberg's archives of pharmacology 20010301 |
| Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010301 |
| A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet. | Food additives and contaminants 20010301 |
| Tissue sphinganine as a biomarker of fumonisin-induced apoptosis. | Food additives and contaminants 20010301 |
| Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1. | Food additives and contaminants 20010301 |
| Elevated expression of mitochondrial NADH dehydrogenase subunit 4/4L genes in vascular endothelial cells undergoing sphingosine-induced apoptosis. | Thrombosis and haemostasis 20010301 |
| Comparative investigation of human stratum corneum ceramides. | Lipids 20010301 |
| Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure. | Acta physiologica Scandinavica 20010301 |
| Treatment of transplant rejection: are the traditional immunosuppressants good enough? | Current opinion in investigational drugs (London, England : 2000) 20010301 |
| Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions. | Biochimica et biophysica acta 20010226 |
| Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. | The Journal of biological chemistry 20010223 |
| FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells. | Biochemical and biophysical research communications 20010223 |
| Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. | International journal of cancer 20010220 |
| G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. | The Journal of biological chemistry 20010216 |
| Platelet-released phospholipids link haemostasis and angiogenesis. | Cardiovascular research 20010216 |
| Inhibition of sodium-calcium exchange by ceramide and sphingosine. | The Journal of biological chemistry 20010209 |
| Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells. | Biochemical and biophysical research communications 20010209 |
| Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells. | Biochemical and biophysical research communications 20010202 |
| t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. | The EMBO journal 20010201 |
| Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. | Journal of neurochemistry 20010201 |
| C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. | Journal of neurochemistry 20010201 |
| Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. | Seminars in cell & developmental biology 20010201 |
| T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain. | Scandinavian journal of immunology 20010201 |
| Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720. | Clinical and experimental immunology 20010201 |
| Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. | Cancer research 20010201 |
| Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. | Diabetologia 20010201 |
| Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. | Journal of hepatology 20010201 |
| Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. | Cell death and differentiation 20010201 |
| Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation models. | Transplant immunology 20010201 |
| Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. | Science's STKE : signal transduction knowledge environment 20010130 |
| Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria. | FEBS letters 20010119 |
| Regulation of phospholipase D (PLD) in growth plate chondrocytes by 24R,25-(OH)2D3 is dependent on cell maturation state (resting zone cells) and is specific to the PLD2 isoform. | Biochimica et biophysica acta 20010115 |
| The effect of a single gavage dose of fumonisin B(1) on the sphinganine and sphingosine levels in vervet monkeys. | Toxicon : official journal of the International Society on Toxinology 20010101 |
| Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. | The Biochemical journal 20010101 |
| Differential regulation of protein tyrosine kinase on free radical production, granule enzyme release, and cytokine synthesis by activated murine peritoneal macrophages. | Biochemical pharmacology 20010101 |
| The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010101 |
| Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? | European journal of biochemistry 20010101 |
| Distinct signals generate repeating striped pattern in the embryonic parasegment. | Molecular cell 20010101 |
| Immunosuppressive drugs in paediatric liver transplantation. | Paediatric drugs 20010101 |
| The role and clinical applications of bioactive lysolipids in ovarian cancer. | Journal of the Society for Gynecologic Investigation 20010101 |
| Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. | Biological chemistry 20010101 |
| FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression. | Transplantation proceedings 20010101 |
| FTY720 prevents chronic rejection of rat heterotopic cardiac allografts. | Transplantation proceedings 20010101 |
| FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model. | Transplantation proceedings 20010101 |
| FTY 720 prevents ischemic reperfusion damage in rat kidneys. | Transplantation proceedings 20010101 |
| Lysosomal involvement in apoptosis. | Redox report : communications in free radical research 20010101 |
| The role of sphingosine and its derivatives in the regulation of Ca2+ homeostasis. | Membrane & cell biology 20010101 |
| Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. | Acta neurobiologiae experimentalis 20010101 |
| Glial cell responses to lipids bound to albumin in serum and plasma. | Progress in brain research 20010101 |
| [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. | Ontogenez 20010101 |
| Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis. | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20010101 |
| In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisins. | Mycopathologia 20010101 |
| Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells. | Anticancer research 20010101 |
| Comparative analysis of glycosylinositol phosphorylceramides from fungi by electrospray tandem mass spectrometry with low-energy collision-induced dissociation of Li(+) adduct ions. | Rapid communications in mass spectrometry : RCM 20010101 |
| FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines. | Transplantation proceedings 20010101 |
| FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects. | Transplantation proceedings 20010101 |
| FTY720: a new dimension in transplantation. | Transplantation proceedings 20010101 |
| T-cell apoptosis triggered by FTY720 via mitochondrial pathway. | Transplantation proceedings 20010101 |
| Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. | Advances in experimental medicine and biology 20010101 |
| Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. | Cell communication & adhesion 20010101 |
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