Home Other Building Blocks Edoxaban tosylate hydrate

Edoxaban tosylate hydrate

CAS No.:
1229194-11-9
Catalog Number:
AG000JRI
Molecular Formula:
C31H40ClN7O8S2
Molecular Weight:
738.2744
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$182
- +
50mg
99%
1 week
United States
$362
- +
100mg
99%
1 week
United States
$460
- +
Product Description
Catalog Number:
AG000JRI
Chemical Name:
Edoxaban tosylate hydrate
CAS Number:
1229194-11-9
Molecular Formula:
C31H40ClN7O8S2
Molecular Weight:
738.2744
MDL Number:
MFCD16038915
IUPAC Name:
N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;4-methylbenzenesulfonic acid;hydrate
InChI:
InChI=1S/C24H30ClN7O4S.C7H8O3S.H2O/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23;1-6-2-4-7(5-3-6)11(8,9)10;/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34);2-5H,1H3,(H,8,9,10);1H2/t13-,15-,17+;;/m0../s1
InChI Key:
PSMMNJNZVZZNOI-SJILXJHISA-N
SMILES:
OS(=O)(=O)c1ccc(cc1)C.CN1CCc2c(C1)sc(n2)C(=O)N[C@@H]1C[C@H](CC[C@@H]1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C.O
UNII:
972203R4EW
Properties
Complexity:
1090  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
737.207g/mol
Formal Charge:
0
Heavy Atom Count:
49  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
738.272g/mol
Monoisotopic Mass:
737.207g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
229A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa. Clinical pharmacokinetics 20160101
Overview of the new oral anticoagulants: opportunities and challenges. Arteriosclerosis, thrombosis, and vascular biology 20150501
The role of factor Xa inhibitors in venous thromboembolism treatment. Vascular health and risk management 20150101
Characterisation of exposure versus response of edoxaban in patients undergoing total hip replacement surgery. Thrombosis and haemostasis 20121101
Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20121001
Oral direct factor Xa inhibitors. Circulation research 20120928
Comparison of antithrombotic and haemorrhagic effects of edoxaban, an oral direct factor Xa inhibitor, with warfarin and enoxaparin in rats. Thrombosis research 20120901
The promise of novel direct oral anticoagulants. Best practice & research. Clinical haematology 20120901
Edoxaban administration following enoxaparin: a pharmacodynamic, pharmacokinetic, and tolerability assessment in human subjects. Thrombosis and haemostasis 20120701
Long-term benefits of preventing venous thromboembolic events. Current medical research and opinion 20120601
Current and future alternatives to warfarin for the prevention of stroke in atrial fibrillation. Critical pathways in cardiology 20120601
In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux. Thrombosis research 20120401
Randomized, multicenter, warfarin-controlled phase II study of edoxaban in Japanese patients with non-valvular atrial fibrillation. Circulation journal : official journal of the Japanese Circulation Society 20120101
Comparison of antithrombotic efficacy between edoxaban, a direct factor Xa inhibitor, and fondaparinux, an indirect factor Xa inhibitor under low and high shear rates. Thrombosis and haemostasis 20111201
Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system. Thrombosis and haemostasis 20111201
[Current status and future of anti-Xa inhibitors]. Rinsho shinkeigaku = Clinical neurology 20111101
The new oral anticoagulants. Clinical medicine (London, England) 20111001
Edoxaban for the prevention of thromboembolic events after surgery. Drugs of today (Barcelona, Spain : 1998) 20111001
[Thromboembolic prophylaxis 2011: is warfarin on the wane?]. Giornale italiano di cardiologia (2006) 20110901
Edoxaban: a new oral direct factor xa inhibitor. Drugs 20110820
Edoxaban: pharmacological principles, preclinical and early-phase clinical testing. Future cardiology 20110701
[New anticoagulants in the prevention and treatment of venous thromboembolism]. Orvosi hetilap 20110619
Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux. Thrombosis and haemostasis 20110601
Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with non-valvular atrial fibrillation. Thrombosis and haemostasis 20110301
Factor Xa and thrombin as targets for new oral anticoagulants. Thrombosis research 20110101
Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism. Annual review of medicine 20110101
Edoxaban tosylate. American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101
A dose-ranging study evaluating the oral factor Xa inhibitor edoxaban for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty. Journal of thrombosis and haemostasis : JTH 20101101
Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: a randomised controlled trial in healthy elderly adults. Thrombosis research 20101001
Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48). American heart journal 20101001
Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement. A randomised double-blind dose-response study. Thrombosis and haemostasis 20100901
Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation. Thrombosis and haemostasis 20100901
[Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100801
Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. Journal of clinical pharmacology 20100701
Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation. Current opinion in cardiology 20100701
New anticoagulants for atrial fibrillation. Seminars in thrombosis and hemostasis 20090701
DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. Journal of thrombosis and haemostasis : JTH 20080901
Properties