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Tosufloxacin tosilate

CAS No.:
115964-29-9
Catalog Number:
AG000H8P
Molecular Formula:
C26H23F3N4O6S
Molecular Weight:
576.5442
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%(HPLC)
In Stock USA
United States
$87
- +
25mg
98%(HPLC)
In Stock USA
United States
$183
- +
100mg
98%(HPLC)
In Stock USA
United States
$511
- +
1g
98%(HPLC)
In Stock USA
United States
$1494
- +
Product Description
Catalog Number:
AG000H8P
Chemical Name:
Tosufloxacin tosilate
CAS Number:
115964-29-9
Molecular Formula:
C26H23F3N4O6S
Molecular Weight:
576.5442
MDL Number:
MFCD01711971
IUPAC Name:
7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;4-methylbenzenesulfonic acid
InChI:
InChI=1S/C19H15F3N4O3.C7H8O3S/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29);2-5H,1H3,(H,8,9,10)
InChI Key:
CSSQVOKOWWIUCX-UHFFFAOYSA-N
SMILES:
Cc1ccc(cc1)S(=O)(=O)O.NC1CCN(C1)c1nc2n(cc(c(=O)c2cc1F)C(=O)O)c1ccc(cc1F)F
Properties
Complexity:
915  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
576.129g/mol
Formal Charge:
0
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
576.547g/mol
Monoisotopic Mass:
576.129g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
163A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
In vitro assessment of the cytotoxicity of six topical antibiotics to four cultured ocular surface cell lines. Biocontrol science 20120601
Synthesis of acrylonitriles through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence. Chemistry (Weinheim an der Bergstrasse, Germany) 20120521
[Intractable pediatric infectious disease: examining the ability of a new drug, tosufloxacin tosilate hydrate for pediatric (discussion)]. The Japanese journal of antibiotics 20111001
[Intractable pediatric infectious disease: examining the ability of a new drug, tosufloxacin tosilate hydrate for pediatric]. The Japanese journal of antibiotics 20101201
[Efficacy of tosufloxacin in genital chlamydial infections]. The Japanese journal of antibiotics 20091001
Corneal deposits after topical tosufloxacin in a patient with poor tear secretion. Cornea 20090101
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. Drug metabolism and pharmacokinetics 20090101
Antibiotic prophylaxis for transrectal prostate biopsy: a prospective randomized study of tosufloxacin versus levofloxacin. International journal of urology : official journal of the Japanese Urological Association 20080701
Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones. The British journal of ophthalmology 20080601
In vitro susceptibilities of bacterial isolates from conjunctival flora to gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin. Eye & contact lens 20080301
[Effectiveness of switch therapy for peritonitis]. The Japanese journal of antibiotics 20070801
Tosufloxacin tosilate-induced thrombocytopenic purpura. The Journal of dermatology 20070701
[Antibacterial activity of tosufloxacin against major organisms detected from patients with respiratory infections]. The Japanese journal of antibiotics 20070401
[Evaluation of efficacy of oral quinolone against Streptococcus pneumoniae AND Haemophilus influenzae with the use of Monte Carlo simulation]. The Japanese journal of antibiotics 20061201
Antibacterial activity of tosufloxacin against major organisms detected from patients with respiratory or otorhinological infections: comparison with the results obtained from organisms isolated about 10 years ago. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Pharmacodynamic evaluation of tosufloxacin against Streptococcus pneumoniae in an in vitro model simulating serum concentration. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060201
In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species. The Journal of antimicrobial chemotherapy 20051201
[Clinical experience of streptococcal balanoposthitis in 47 healthy adult males]. Hinyokika kiyo. Acta urologica Japonica 20051101
Antimicrobial activities of tosufloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella branhamella catarrhalis isolated from otolaryngological infectious diseases. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20051001
Terbium sensitized determination of tosufloxacin using electrochemiluminescence method. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050401
VapB-positive Rhodococcus equi infection in an HIV-infected patient in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20050201
[Clinical study of male urethritis in Oogaki Municipal Hospital]. Hinyokika kiyo. Acta urologica Japonica 20050101
An unusual form of crystal-forming chronic interstitial nephritis following long-term exposure to tosufloxacin tosilate. American journal of kidney diseases : the official journal of the National Kidney Foundation 20041101
Anaphylaxis due to tosufloxacin tosilate. The Journal of dermatology 20030901
[Salmonella infections]. Nihon rinsho. Japanese journal of clinical medicine 20030201
[Alteration of antibacterial activity of tosufloxacin and various antibacterial agents against Streptococcus pneumoniae]. The Japanese journal of antibiotics 20030201
[In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone]. The Japanese journal of antibiotics 20021201
Pharmacokinetics and safety assessment of tosufloxacin tosilate. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020301
Clinical assessment of tosufloxacin tosilate. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020301
Evaluation of in-vitro and in-vivo antibacterial activity of tosufloxacin tosilate. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20011201
Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment. Oral oncology 20010701
Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010301
Accumulation of ofloxacin and tosufloxacin in fluoroquinolone-resistant E coli. Acta pharmacologica Sinica 20010301
Comparative in-vitro activities of the new quinolone, Bay y 3118, and ciprofloxacin, sparfloxacin, tosufloxacin, CI-960 and CI-990. The Journal of antimicrobial chemotherapy 19930401
[Nephrotoxicity test on T-3262 in rats with experimental nephropathy]. The Japanese journal of antibiotics 19890401
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