Home Carboxys 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

CAS No.:
115956-12-2
Catalog Number:
AG000H7X
Molecular Formula:
C19H20N2O3
Molecular Weight:
324.3737
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$111
- +
10mg
≥98%
1 week
United States
$143
- +
25mg
≥98%
1 week
United States
$260
- +
50mg
≥98%
1 week
United States
$436
- +
Product Description
Catalog Number:
AG000H7X
Chemical Name:
1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
CAS Number:
115956-12-2
Molecular Formula:
C19H20N2O3
Molecular Weight:
324.3737
MDL Number:
MFCD00865542
IUPAC Name:
[(3S,7R)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1H-indole-3-carboxylate
InChI:
InChI=1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13+,14?
InChI Key:
UKTAZPQNNNJVKR-AKJUYKBHSA-N
SMILES:
O=C1CN2[C@H]3C[C@H]1C[C@@H]2C[C@H](C3)OC(=O)c1c[nH]c2c1cccc2
EC Number:
601-402-4
Properties
Complexity:
535  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
324.147g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
324.38g/mol
Monoisotopic Mass:
324.147g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
62.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4  
Literature
Title Journal
Optimization of sample pretreatment methods for simultaneous determination of dolasetron and hydrodolasetron in human plasma by HPLC-ESI-MS. Journal of chromatographic science 20121001
Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120501
Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery. Korean journal of anesthesiology 20120301
A network meta-analysis on the efficacy of serotonin type 3 receptor antagonists used in adults during the first 24 hours for postoperative nausea and vomiting prophylaxis. Clinical therapeutics 20120201
A practical and direct comparison of intrinsic metabolic clearance of several non-CYP enzyme substrates in freshly isolated and cryopreserved hepatocytes. Drug metabolism and pharmacokinetics 20120101
Reduction in the incidence of shivering with perioperative dexmedetomidine: A randomized prospective study. Journal of anaesthesiology, clinical pharmacology 20120101
Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy. Cancer management and research 20120101
Cardiovascular events in cancer patients treated with highly or moderately emetogenic chemotherapy: results from a population-based study. Journal of cancer epidemiology 20120101
Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study. BMC health services research 20120101
Management of postoperative nausea and vomiting in women scheduled for breast cancer surgery. Journal of anesthesia 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Single-dose palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with aggressive non-Hodgkin's lymphoma receiving moderately emetogenic chemotherapy containing steroids: results of a phase II study from the Gruppo Italiano per lo Studio dei Linfomi (GISL). Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20111001
Retraction note to: Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110901
Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following moderately emetogenic chemotherapy: a randomized, multicenter, phase III trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801
Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT3R) in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110601
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy: Retraction. European journal of anaesthesiology 20110601
5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities. Journal of clinical anesthesia 20110601
Combination treatment with intrahepatic arterial infusion and intratumoral injection chemotherapy in patients with far-advanced hepatocellular carcinoma and arterioportal or arteriovenous shunts: preliminary results. The Korean journal of hepatology 20110601
A randomised, double-blind, placebo-controlled trial of dolasetron, a 5-hydroxytryptamine 3 receptor antagonist, in patients with fibromyalgia. European journal of pain (London, England) 20110501
Dolasetron for preventing postanesthetic shivering: Retraction. Anesthesia and analgesia 20110501
Retraction Notice: Current review of ramosetron in the prevention of postoperative nausea and vomiting. Current drug safety 20110401
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists. Cancer chemotherapy and pharmacology 20110301
Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Surgical endoscopy 20110301
Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics. International journal of clinical pharmacy 20110201
Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma. Core evidence 20110101
BICEPP: an example-based statistical text mining method for predicting the binary characteristics of drugs. BMC bioinformatics 20110101
Genetic polymorphisms in the three malaysian races effect granisetron clinical antiemetic actions in breast cancer patients receiving chemotherapy. Asian Pacific journal of cancer prevention : APJCP 20110101
Short term non-invasive ventilation post-surgery improves arterial blood-gases in obese subjects compared to supplemental oxygen delivery - a randomized controlled trial. BMC anesthesiology 20110101
Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery. Saudi journal of anaesthesia 20110101
Symptomatic sinus bradycardia: A rare adverse effect of intravenous ondansetron. Saudi journal of anaesthesia 20110101
Comparison of ondansetron and combination of ondansetron and dexamethasone as a prophylaxis for postoperative nausea and vomiting in adults undergoing elective laparoscopic surgery. Journal of emergencies, trauma, and shock 20110101
Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine. Journal of drug delivery 20110101
Treating nausea and vomiting in palliative care: a review. Clinical interventions in aging 20110101
Current concepts in the management of postoperative nausea and vomiting. Anesthesiology research and practice 20110101
Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone. Korean journal of anesthesiology 20101101
Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain research 20100917
Retraction Notice: Clinical Management of Postoperative Vomiting after Strabismus Surgery in Children. Current drug safety 20100401
Comparison of perioperative oral multimodal analgesia versus IV PCA for spine surgery. Journal of spinal disorders & techniques 20100401
Acute vomiting in cats: rational treatment selection. Journal of feline medicine and surgery 20100301
Effect of ramosetron on shivering during spinal anesthesia. Korean journal of anesthesiology 20100301
Optimizing emetic control in children receiving antineoplastic therapy: beyond the guidelines. Paediatric drugs 20100101
Other drugs acting on nervous system associated with QT-interval prolongation. Current drug safety 20100101
Safety and effectiveness of outpatient laparoscopic cholecystectomy in a teaching hospital: a prospective study of 110 consecutive patients. BMC research notes 20100101
Differences in efficacy and safety of pharmaceutical treatments between men and women: an umbrella review. PloS one 20100101
A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. American journal of therapeutics 20100101
Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review. Cancer management and research 20100101
Acute gastroenteritis: from guidelines to real life. Clinical and experimental gastroenterology 20100101
Palonosetron: in the prevention of nausea and vomiting. Drugs 20091112
Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090901
Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasone. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090901
Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance. Current cardiology reviews 20090801
Prophylactic granisetron vs pethidine for the prevention of postoperative shivering: a randomized control trial. Indian journal of anaesthesia 20090601
5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials. Journal of clinical medicine research 20090601
Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial. The Lancet. Oncology 20090201
Retraction Notice: Current Management of Vomiting after Tonsillectomy in Children. Current drug safety 20090101
Management of postoperative nausea and vomiting: focus on palonosetron. Therapeutics and clinical risk management 20090101
Bilateral infraorbital nerve blocks decrease postoperative pain but do not reduce time to discharge following outpatient nasal surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20090101
Casopitant: a novel NK(1)-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Therapeutics and clinical risk management 20090101
Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron. Cancer management and research 20090101
Palonosetron for the prevention of chemotherapy-induced nausea and vomiting: approval and efficacy. Cancer management and research 20090101
Dolasetron and QT interval. Emergency medicine journal : EMJ 20081001
The acute effect of tropisetron on ECG parameters in cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080901
Fatal metformin overdose presenting with progressive hyperglycemia. The western journal of emergency medicine 20080801
Ondansetron induced fatal ventricular tachycardia. Indian journal of pharmacology 20080801
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401
Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients' comfort. A placebo-controlled comparison of dolasetron and droperidol. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20080401
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. AANA journal 20080201
Chemotherapy-and cancer-related nausea and vomiting. Current oncology (Toronto, Ont.) 20080101
[Pharmacokinetic and pharmacodynamic features of palonosetron]. Tumori 20080101
[Meta-analysis of phase III studies with palonosetron in the prevention of vomiting induced by moderately emetogenic chemotherapy]. Tumori 20080101
[Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects]. Tumori 20080101
Retraction Notice: The Benefits and Risks of Different Therapies in Preventing Postoperative Nausea and Vomiting in Patients Undergoing Thyroid Surgery. Current drug safety 20080101
Mining clinical relationships from patient narratives. BMC bioinformatics 20080101
Dolasetron-induced torsades de pointes. Journal of clinical anesthesia 20071201
Palonosetron as an anti-emetic and anti-nausea agent in oncology. Therapeutics and clinical risk management 20071201
A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20070901
[Prevention of postoperative nausea and vomiting]. Ugeskrift for laeger 20070813
The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting. Anaesthesia 20070801
Ondansetron oral disintegrating tablets for the prevention of postoperative vomiting in children undergoing strabismus surgery. Therapeutics and clinical risk management 20070801
Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review. Emergency medicine journal : EMJ 20070701
Antiemetic agents. Oncology (Williston Park, N.Y.) 20070701
[Prevention and treatment of postoperative nausea and vomiting in children. An evidence-based approach]. Annales francaises d'anesthesie et de reanimation 20070601
Management of platinum-based chemotherapy-induced acute nausea and vomiting: is there a superior serotonin receptor antagonist? Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20070601
Randomized comparison of two anti-emetic strategies in high-risk patients undergoing day-case gynaecological surgery. British journal of anaesthesia 20070401
Management of radiation-induced nausea and vomiting. Experimental hematology 20070401
Safety and efficacy of a continuous infusion, patient-controlled antiemetic pump for children receiving emetogenic chemotherapy. Pediatric blood & cancer 20070301
Tremor in multiple sclerosis. Journal of neurology 20070201
[Dolasetron and shivering. A prospective randomized placebo-controlled pharmaco-economic evaluation]. Der Anaesthesist 20070101
Are all 5-HT3 receptor antagonists the same? Journal of the National Comprehensive Cancer Network : JNCCN 20070101
Management of postoperative nausea and vomiting in children. Paediatric drugs 20070101
Systemic anticancer therapy in gynecological cancer patients with renal dysfunction. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting. Paediatric drugs 20070101
Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC cancer 20070101
Aprepitant: the evidence for its place in the prevention of chemotherapy-induced nausea and vomiting. Core evidence 20070101
Pharmacological prophylaxis and management of adult postoperative/postdischarge nausea and vomiting. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20061201
Inspired oxygen fraction of 0.8 compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy. British journal of anaesthesia 20061101
Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. British journal of anaesthesia 20061101
Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist. Future oncology (London, England) 20061001
Dolasetron versus ondansetron as single-agent prophylaxis for patients at increased risk for postoperative nausea and vomiting: a prospective, double-blind, randomized trial. Military medicine 20060901
Ethics, marketing, and the medical literature. Anesthesia and analgesia 20060801
Drugs for preventing postoperative nausea and vomiting. The Cochrane database of systematic reviews 20060719
Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers. Journal of clinical pharmacology 20060701
Relative efficacy of ondansetron, granisetron, dolasetron and palonosetron in controlling acute nausea and vomiting associated with platinum-based chemotherapy. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601
Meta-analysis of the safety of 5-HT3 antagonists with dexamethasone or droperidol for prevention of PONV. The Annals of pharmacotherapy 20060501
Meta-analysis of the use of rescue antiemetics following PONV prophylactic failure with 5-HT3 antagonist/dexamethasone versus single-agent therapies. The Annals of pharmacotherapy 20060501
Paravertebral blocks provide superior same-day recovery over general anesthesia for patients undergoing inguinal hernia repair. Anesthesia and analgesia 20060401
Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype. Anesthesia and analgesia 20060401
Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis. Supportive cancer therapy 20060401
Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics. Drug metabolism and disposition: the biological fate of chemicals 20060301
New antiemetic drugs. Annals of oncology : official journal of the European Society for Medical Oncology 20060301
Measuring the maintenance of daily life activities using the functional living index-emesis (FLIE) in patients receiving moderately emetogenic chemotherapy. The journal of supportive oncology 20060101
The role of 5-HT3 receptor antagonists in preventing postoperative nausea and vomiting. AORN journal 20060101
Laparoscopic cholecystectomy and management of biliary tract stones in a freestanding ambulatory surgery center. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20060101
Anesthesiologists' practice patterns for treatment of postoperative nausea and vomiting in the ambulatory Post Anesthesia Care Unit. BMC anesthesiology 20060101
New approaches to chemotherapy-induced nausea and vomiting: from neuropharmacology to clinical investigations. Cancer journal (Sudbury, Mass.) 20060101
Prophylaxis of postoperative nausea and vomiting in patients scheduled for breast surgery. Clinical drug investigation 20060101
Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trials. BMC anesthesiology 20060101
Treatment of postoperative nausea and vomiting with dolasetron versus ondansetron: is there a conflict of interest? Anesthesia and analgesia 20051201
Employment of substandard antiemetic prophylaxis in recent trials of chemotherapy-induced nausea and vomiting. The Annals of pharmacotherapy 20051101
Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double-blinded, placebo-controlled study. Anesthesia and analgesia 20051101
Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Medical science monitor : international medical journal of experimental and clinical research 20051001
Dolasetron and peri-operative cardiac arrhythmia. Anaesthesia 20050901
Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesthesia and analgesia 20050901
5HT3-receptor antagonists as antiemetics in cancer. Drug and therapeutics bulletin 20050801
Update on anti-emetics for chemotherapy-induced emesis. Internal medicine journal 20050801
5-hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: can we safely reduce the dose of administered agents? Cancer 20050701
Prevention and treatment of postoperative nausea and vomiting. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050615
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteers. Current medical research and opinion 20050401
Docetaxel (Taxotere), cisplatin, UFT, and leucovorin combination chemotherapy in advanced gastric cancer. British journal of cancer 20050314
Acute emesis: moderately emetogenic chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20050201
Dolasetron versus ondansetron for the treatment of postoperative nausea and vomiting. Anesthesia and analgesia 20050201
Coronary vasospasm leading to an acute myocardial infarction after the administration of dolasetron. Journal of clinical anesthesia 20050201
Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS drugs 20050101
The utility of antiemetics in the prevention and treatment of postoperative nausea and vomiting in patients scheduled for laparoscopic cholecystectomy. Current pharmaceutical design 20050101
The Breast Journal regrettably is retracting a manuscript entitled, ' Dolasetron decreases postoperative nausea and vomiting after breast surgery'. The breast journal 20050101
A randomized, multicenter, open-label comparison of the antiemetic efficacy of dolasetron versus ondansetron for the prevention of nausea and vomiting during high-dose myeloablative chemotherapy. Supportive cancer therapy 20050101
Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol. The Journal of pharmacy and pharmacology 20041201
Open-label, randomized comparison of the efficacy of intravenous dolasetron mesylate and ondansetron in the prevention of acute and delayed cisplatin-induced emesis in cancer patients. Cancer research and treatment : official journal of Korean Cancer Association 20041201
5-HT3 receptor antagonists for prevention of late acute-onset emesis. The Annals of pharmacotherapy 20041001
Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials. Anesthesia and analgesia 20040901
Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Ophthalmology 20040801
Timing of administration of dolasetron affects dose necessary to prevent postoperative nausea and vomiting. Journal of clinical anesthesia 20040801
A comparison of infraclavicular nerve block versus general anesthesia for hand and wrist day-case surgeries. Anesthesiology 20040701
Granisetron vs dolasetron for acute chemotherapy-induced nausea and vomiting (CINV) in high and moderately high emetogenic chemotherapy: an open-label pilot study. Current medical research and opinion 20040601
Palonosetron: a unique 5-HT3 receptor antagonist indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. Clinical advances in hematology & oncology : H&O 20040501
Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results. British journal of cancer 20040405
Ondansetron versus dolasetron: a comparison study in the prevention of postoperative nausea and vomiting in patients undergoing gynecological procedures. AANA journal 20040401
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040101
Palonosetron. Drugs 20040101
Is amiodarone a safe antiarrhythmic to use in supraventricular tachyarrhythmias after lung cancer surgery? BMC surgery 20040101
Same old story? Do we need to modify our supportive care treatment of elderly cancer patients? Focus on antiemetics. Drugs & aging 20040101
Spectrum of use and tolerability of 5-HT3 receptor antagonists. Scandinavian journal of rheumatology. Supplement 20040101
Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron. Cancer 20031201
Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis. Expert opinion on pharmacotherapy 20031201
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer 20031117
Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery. Annals of plastic surgery 20031101
[Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20031101
Stability of dolasetron in two oral liquid vehicles. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031101
Comparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in children. European journal of anaesthesiology 20031001
Double-blind crossover study with dolasetron mesilate, a 5-HT3 receptor antagonist in cerebellar syndrome secondary to multiple sclerosis. Journal of neurology 20031001
Electrocardiographic and cardiovascular effects of the 5-hydroxytryptamine3 receptor antagonists. The Annals of pharmacotherapy 20030901
Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert opinion on pharmacotherapy 20030901
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters 20030818
A comparison of the costs and efficacy of ondansetron and dolasetron in the prophylaxis of postoperative vomiting in pediatric patients undergoing ambulatory surgery. Anesthesia and analgesia 20030801
Dolasetron for the prevention of postoperative vomiting in children undergoing strabismus surgery. Paediatric anaesthesia 20030701
Cost-effectiveness of antiemetics use during cancer chemotherapy. Expert review of pharmacoeconomics & outcomes research 20030601
Patient outcomes after therapeutic interchange of dolasetron for granisetron. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030515
Arrhythmogenic potential of antiemetics: perspectives on risk-benefits. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030301
Dolasetron prophylaxis reduces nausea and postanaesthesia recovery time after remifentanil infusion during monitored anaesthesia care for extracorporeal shock wave lithotripsy. British journal of anaesthesia 20030201
Antiemetic prophylaxis for office-based surgery: are the 5-HT3 receptor antagonists beneficial? Anesthesiology 20030201
[Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone]. Der Anaesthesist 20030201
The efficacy and cost-effectiveness of prophylactic 5-hydroxytryptamine3 receptor antagonists: tropisetron, ondansetron and dolasetron. Anaesthesia and intensive care 20030201
Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting. Drug safety 20030101
Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy. Health and quality of life outcomes 20030101
Writers challenge points made in article about antiemetic therapy. Oncology nursing forum 20030101
QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs. American journal of therapeutics 20030101
Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models. Journal of receptor and signal transduction research 20030101
A systematic approach to the management of postoperative nausea and vomiting. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20021201
Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20021201
Ondansetron and dolasetron provide equivalent postoperative vomiting control after ambulatory tonsillectomy in dexamethasone-pretreated children. Anesthesia and analgesia 20021101
Pharmacological prevention of postanesthetic shivering. Anesthesia and analgesia 20021001
[Dolasetron reduces pain on injection of propofol]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020901
Progress in preventing chemotherapy-induced nausea and vomiting. Cleveland Clinic journal of medicine 20020801
Probable serotonin syndrome variant in a patient receiving a selective serotonin reuptake inhibitor and a 5-HT3 receptor antagonist. Journal of psychopharmacology (Oxford, England) 20020601
Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy. Anesthesiology 20020601
Granisetron vs ondansetron: is it a question of duration of 5-HT3 receptor blockade? British journal of cancer 20020520
The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy. Anaesthesia and intensive care 20020401
Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin. British journal of cancer 20020121
Dolasetron for preventing postanesthetic shivering. Anesthesia and analgesia 20020101
[Prophylaxis of Postoperative Nausea and Vomiting FollowingGynaecological Laparoscopy]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020101
The cardiotoxic potential of the 5-HT(3) receptor antagonist antiemetics: is there cause for concern? The oncologist 20020101
Dolasetron decreases postoperative nausea and vomiting after breast surgery. The breast journal 20020101
5-HT(3)-receptor antagonists for the treatment of nausea and vomiting: a reappraisal of their side-effect profile. The oncologist 20020101
5-HT3-receptor antagonists and the cytochrome P450 system: clinical implications. Cancer journal (Sudbury, Mass.) 20020101
Compatibility and stability of 5-HT3 receptor antagonists: a pharmacology review. Oncology nursing forum 20020101
Implementing evidence based antiemetic guidelines in the oncology setting: results of a 4-month prospective intervention study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20011101
The effect of timing of dolasetron administration on its efficacy as a prophylactic antiemetic in the ambulatory setting. Anesthesia and analgesia 20011001
[Prophylaxis of nausea and vomiting after thyroid surgery: comparison of oral and intravenous dolasetron with intravenous droperidol and placebo]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20010701
Efficacy of single-dose intravenous dolasetron versus ondansetron in the prevention of postoperative nausea and vomiting. Clinical therapeutics 20010601
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. European journal of anaesthesiology 20010401
Dolasetron for chemo nausea. RN 20010301
Randomized open-label trial of dolasetron for the control of nausea and vomiting associated with high-dose chemotherapy with hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101
5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs 19980201
Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery. Drugs 19970801
A double-blind, multicentre comparison of intravenous dolasetron mesilate and metoclopramide in the prevention of nausea and vomiting in cancer patients receiving high-dose cisplatin chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 19970101
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