Home Carboxys 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, (3R)-

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, (3R)-

CAS No.:
115103-54-3
Catalog Number:
AG000GAY
Molecular Formula:
C20H25NO2S2
Molecular Weight:
375.5480
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG000GAY
Chemical Name:
3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, (3R)-
CAS Number:
115103-54-3
Molecular Formula:
C20H25NO2S2
Molecular Weight:
375.5480
MDL Number:
MFCD00865317
IUPAC Name:
(3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
InChI:
InChI=1S/C20H25NO2S2/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23)/t16-/m1/s1
InChI Key:
PBJUNZJWGZTSKL-MRXNPFEDSA-N
SMILES:
OC(=O)[C@@H]1CCCN(C1)CCC=C(c1sccc1C)c1sccc1C
UNII:
Z80I64HMNP
Properties
Complexity:
474  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
375.133g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
375.545g/mol
Monoisotopic Mass:
375.133g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
97A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chemical research in toxicology 20150518
Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring. Biomedical chromatography : BMC 20121201
Separate and combined effects of the GABA(B) agonist baclofen and Δ9-THC in humans discriminating Δ9-THC. Drug and alcohol dependence 20121101
The cost effectiveness of newer epilepsy treatments: a review of the literature on partial-onset seizures. PharmacoEconomics 20121001
Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice. Journal of neural transmission (Vienna, Austria : 1996) 20120801
Chronic tiagabine administration and aggressive responding in individuals with a history of substance abuse and antisocial behavior. Journal of psychopharmacology (Oxford, England) 20120701
Chemical properties of antiepileptic drugs (AEDs). Advanced drug delivery reviews 20120701
Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs? European journal of pharmacology 20120505
Separate and combined effects of the GABA reuptake inhibitor tiagabine and Δ9-THC in humans discriminating Δ9-THC. Drug and alcohol dependence 20120401
Beneficial and adverse psychotropic effects of antiepileptic drugs in patients with epilepsy: a summary of prevalence, underlying mechanisms and data limitations. CNS drugs 20120401
Prevalence of treated epilepsy in Korea based on national health insurance data. Journal of Korean medical science 20120301
Identification of tiagabine degradation products using liquid chromatography with electrospray ionization multistage mass spectrometry and ultra-performance liquid chromatography/high-resolution mass spectrometry. Rapid communications in mass spectrometry : RCM 20120215
GABAA-positive modulator selective discriminative stimulus effects of 1,1,1-trichloroethane vapor. Drug and alcohol dependence 20120201
Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis. Epilepsy research 20120201
Neuromodulators for pain management in rheumatoid arthritis. The Cochrane database of systematic reviews 20120118
Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects. Expert opinion on drug metabolism & toxicology 20120101
Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO). Current topics in medicinal chemistry 20120101
Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum. PLoS pathogens 20120101
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PloS one 20120101
Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity. PloS one 20120101
Clinical utility of adjunctive retigabine in partial onset seizures in adults. Therapeutics and clinical risk management 20120101
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. PloS one 20120101
Forty-year-old diabetic lady with tightness in lower limbs. Annals of Indian Academy of Neurology 20120101
Astrocytes convert network excitation to tonic inhibition of neurons. BMC biology 20120101
Perisynaptic GABA Receptors The Overzealous Protector. Advances in pharmacological sciences 20120101
Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures. International journal of molecular sciences 20120101
Tiagabine add-on for drug-resistant partial epilepsy. The Cochrane database of systematic reviews 20120101
A steered molecular dynamics study of binding and translocation processes in the GABA transporter. PloS one 20120101
Synthesis and pharmacological properties of new GABA uptake inhibitors. Pharmacological reports : PR 20120101
New developments in the treatment of partial-onset epilepsy. Neuropsychiatric disease and treatment 20120101
Tiagabine in the maintenance treatment of bipolar disorder. The Cochrane database of systematic reviews 20111207
Review of therapeutic options for adjuvant treatment of focal seizures in epilepsy: focus on lacosamide. CNS drugs 20111205
Transition to absence seizures and the role of GABA(A) receptors. Epilepsy research 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Pharmacotherapy for anxiety disorders in children and adolescents. Dialogues in clinical neuroscience 20111201
Neuroimaging in anxiety disorders. Dialogues in clinical neuroscience 20111201
Experimental panic provocation in healthy man-a translational role in anti-panic drug development? Dialogues in clinical neuroscience 20111201
Nitric oxide, epileptic seizures, and action of antiepileptic drugs. CNS & neurological disorders drug targets 20111101
Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse. Neuroscience 20111013
Treatment options in juvenile myoclonic epilepsy. Current treatment options in neurology 20110801
Antiepileptic drug discovery: does mechanism of action matter? Epilepsy & behavior : E&B 20110801
Gabapentin: An update of its pharmacological properties and therapeutic use in epilepsy. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110801
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. The Journal of pharmacology and experimental therapeutics 20110701
Analyte and internal standard cross signal contributions and their impact on quantitation in LC-MS based bioanalysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701
Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis. Epilepsia 20110701
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy research 20110601
The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of biological chemistry 20110506
Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats. Psychopharmacology 20110501
Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors. The European journal of neuroscience 20110401
Strategies and practices in off-label marketing of pharmaceuticals: a retrospective analysis of whistleblower complaints. PLoS medicine 20110401
Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis. BMJ (Clinical research ed.) 20110311
Risk factors for complications of drug-induced seizures. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20110301
Depressogenic effects of medications: a review. Dialogues in clinical neuroscience 20110301
Analysis of electrical brain waves in neurotoxicology: γ-hydroxybutyrate. Current neuropharmacology 20110301
Pregabalin effect on steady-state pharmacokinetics of carbamazepine, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, and tiagabine. Epilepsia 20110201
An historical perspective on GABAergic drugs. Future medicinal chemistry 20110201
GABA transport inhibitors and seizure protection: the past and future. Future medicinal chemistry 20110201
Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorganic & medicinal chemistry letters 20110101
Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PloS one 20110101
The societal costs of insomnia. Neuropsychiatric disease and treatment 20110101
Treatment of alcohol dependence with low-dose topiramate: an open-label controlled study. BMC psychiatry 20110101
Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Pharmacological reports : PR 20110101
Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy. Molecular pain 20110101
Epilepsy (partial). BMJ clinical evidence 20110101
Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study. AIDS research and therapy 20110101
Management of provoked seizure. Annals of Indian Academy of Neurology 20110101
Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis. Reproductive biology and endocrinology : RB&E 20110101
Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence. Drug, healthcare and patient safety 20110101
Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia. Frontiers in systems neuroscience 20110101
Comparison of antinociceptive effect of the antiepileptic drug gabapentin to that of various dosage combinations of gabapentin with lamotrigine and topiramate in mice and rats. Journal of neurosciences in rural practice 20110101
Dysembryoplastic neuroepithelial tumor and probable sudden unexplained death in epilepsy: a case report. Journal of medical case reports 20110101
Identification of novel functional inhibitors of acid sphingomyelinase. PloS one 20110101
Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors. Advances in pharmacological sciences 20110101
Treatment options for refractory and difficult to treat seizures: focus on vigabatrin. Therapeutics and clinical risk management 20110101
Treatment of generalized anxiety disorder: a comprehensive review of the literature for psychopharmacologic alternatives to newer antidepressants and benzodiazepines. The primary care companion for CNS disorders 20110101
A comprehensive review of the literature on epilepsy in selected countries in emerging markets. Neuropsychiatric disease and treatment 20110101
Novel pharmacotherapeutic treatments for cocaine addiction. BMC medicine 20110101
Effect of Gentiana olivieri on experimental epilepsy models. Pharmacognosy magazine 20110101
Design of a controlled release liquid formulation of lamotrigine. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101
GABA(A) positive modulator and NMDA antagonist-like discriminative stimulus effects of isoflurane vapor in mice. Psychopharmacology 20101201
Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models. Epilepsy research 20101201
Use of antiepileptic drugs for hyperkinetic movement disorders. Current neuropharmacology 20101201
Is reduced ornithine-δ-aminotransferase activity the cause of vigabatrin-associated visual field defects? Epilepsy research 20101101
New users of the anticonvulsants gabapentin, lamotrigine, oxcarbazepine or tiagabine are at increased risk of suicidal acts compared with new users of topiramate. Evidence-based mental health 20101101
Effects of antiepileptic drugs on associative LTP-like plasticity in human motor cortex. The European journal of neuroscience 20101001
Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and Ampakines. PLoS currents 20100920
An open pilot study of tiagabine in alcohol dependence: tolerability and clinical effects. Journal of psychopharmacology (Oxford, England) 20100901
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures. Neurochemical research 20100901
Do antiepileptic drugs increase the risk of suicidality in adult patients with epilepsy?: a critically appraised topic. The neurologist 20100901
Antiepileptic drug interactions - principles and clinical implications. Current neuropharmacology 20100901
A convergent approach to (R)-Tiagabine by a regio- and stereocontrolled hydroiodination of alkynes. Organic & biomolecular chemistry 20100807
Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice. Epilepsia 20100801
Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology 20100727
Homology modelling of the GABA transporter and analysis of tiagabine binding. ChemMedChem 20100705
Epilepsy (partial). BMJ clinical evidence 20100628
Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. European journal of medicinal chemistry 20100601
Predictors of suicidal ideation in people with epilepsy living in Korea. Journal of clinical neurology (Seoul, Korea) 20100601
Placebo effects in neurological diseases. Journal of medicine and life 20100515
Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience 20100505
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. Journal of psychopharmacology (Oxford, England) 20100501
[Antiepileptic drugs in North America]. Brain and nerve = Shinkei kenkyu no shinpo 20100501
Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA 20100414
Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury. Journal of neurotrauma 20100401
Dose-related levetiracetam-induced reticulated drug eruption. Journal of drugs in dermatology : JDD 20100401
Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs. Pharmacology & therapeutics 20100301
Emergent complications of the newer anticonvulsants. The Journal of emergency medicine 20100201
Behavioral and cognitive effects of anti-epileptic drugs. Discovery medicine 20100201
Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro. British journal of pharmacology 20100101
Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert review of neurotherapeutics 20100101
Effects of Pharmacological Block of GABA(A) Receptors on Pallidal Neurons in Normal and Parkinsonian State. Frontiers in cellular neuroscience 20100101
[Therapeutic drug monitoring of tiagabine]. Therapie 20100101
Assessing structure, function and druggability of major inhibitory neurotransmitter gamma-aminobutyrate symporter subtypes. Current medicinal chemistry 20100101
Review of topiramate for the treatment of epilepsy in elderly patients. Clinical interventions in aging 20100101
Medications acting on the GABA system in the treatment of alcoholic patients. Current pharmaceutical design 20100101
Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients. Neuropsychiatric disease and treatment 20100101
Management of refractory complex partial seizures: current state of the art. Neuropsychiatric disease and treatment 20100101
GABAB receptors in addiction and its treatment. Advances in pharmacology (San Diego, Calif.) 20100101
Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions. Perspectives in medicinal chemistry 20100101
Assessing suicidal risk with antiepileptic drugs. Neuropsychiatric disease and treatment 20100101
GATMD: γ-aminobutyric acid transporter mutagenesis database. Database : the journal of biological databases and curation 20100101
Advances in epilepsy: new perspectives on new-onset epilepsy, comorbidities, and pharmacotherapy. F1000 medicine reports 20100101
Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients. Nutrition journal 20100101
Antiepileptic drugs and suicidality. Drug, healthcare and patient safety 20100101
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clinical pharmacology : advances and applications 20100101
Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations. Psychoneuroendocrinology 20091101
Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder. Pharmacopsychiatry 20091101
Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors. Bioorganic & medicinal chemistry 20090915
Pharmacologic treatment of impulsive aggression with antiepileptic drugs. Current treatment options in neurology 20090901
Basal ganglia neuroprotection with anticonvulsants after energy stress: a comparative study. Metabolic brain disease 20090901
Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice. Methods and findings in experimental and clinical pharmacology 20090901
Economic Evaluation of Add-on Levetiracetam for the Treatment of Refractory Partial Epilepsy in Korea. Psychiatry investigation 20090901
Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis. European journal of pain (London, England) 20090801
The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders. Journal of neural transmission (Vienna, Austria : 1996) 20090601
Questionable tolerability of tiagabine in generalized anxiety disorder. Journal of clinical psychopharmacology 20090601
[Pharmacotherapy of substance dependence and withdrawal syndromes]. Therapeutische Umschau. Revue therapeutique 20090601
Antiepileptic drug monotherapy: the initial approach in epilepsy management. Current neuropharmacology 20090601
Transitional polytherapy: tricks of the trade for monotherapy to monotherapy AED conversions. Current neuropharmacology 20090601
Truly 'rational' polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. Current neuropharmacology 20090601
Minimizing AED adverse effects: improving quality of life in the interictal state in epilepsy care. Current neuropharmacology 20090601
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs. Journal of neurochemistry 20090501
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. European journal of pharmacology 20090301
[Empirical evidence for the use of anticonvulsants in personality disorders]. Fortschritte der Neurologie-Psychiatrie 20090301
Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201
For publication: Tiagabine in the discontinuation of long-term benzodiazepine use. Psychiatry and clinical neurosciences 20090201
Increase in tiagabine serum concentration with coadministration of gemfibrozil. The Annals of pharmacotherapy 20090201
Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography. Expert opinion on drug metabolism & toxicology 20090201
Epilepsy. BMJ clinical evidence 20090128
A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101
Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study. Acta neurologica Scandinavica 20090101
Tiagabine augmentation to fluvoxamine-risperidone combination in the treatment of obsessive-compulsive disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101
Stiff person syndrome. Frontiers of neurology and neuroscience 20090101
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. Advances in medical sciences 20090101
Managing epilepsy in women of childbearing age. Drug safety 20090101
Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice. Pharmacological reports : PR 20090101
Synergistic interaction of gabapentin with tiagabine in the hot-plate test in mice: an isobolographic analysis. Pharmacological reports : PR 20090101
Gabapentin and tiagabine for social anxiety: a randomized, double-blind, crossover study of 8 adults. Primary care companion to the Journal of clinical psychiatry 20090101
Anticonvulsants in the treatment of major depressive disorder: an overview. Harvard review of psychiatry 20090101
Glutamate uptake triggers transporter-mediated GABA release from astrocytes. PloS one 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Treatment of refractory complex partial seizures: role of vigabatrin. Neuropsychiatric disease and treatment 20090101
Migraine: an overview. The open neurology journal 20090101
Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures. Pharmacological reports : PR 20090101
Neuroimaging in psychiatry: from bench to bedside. Frontiers in human neuroscience 20090101
Role of multidrug transporters in neurotherapeutics. Annals of Indian Academy of Neurology 20090101
ATP signalling in epilepsy. Purinergic signalling 20081201
Pregabalin for the management of partial epilepsy. Neuropsychiatric disease and treatment 20081201
Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 20081104
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. European journal of medicinal chemistry 20081101
Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. Naunyn-Schmiedeberg's archives of pharmacology 20081101
Tiagabine for essential tremor: an open-label trial. Movement disorders : official journal of the Movement Disorder Society 20081015
On the presence of 3H-GABA uptake mechanism in bovine spermatozoa. Animal reproduction science 20081001
Optimizing prophylactic treatment of migraine: Subtypes and patient matching. Therapeutics and clinical risk management 20081001
[Seizure exacerbation caused by antiepileptic drugs]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080925
Cognitive effects of antiepileptic drugs. Journal of clinical neurology (Seoul, Korea) 20080901
Metabolism of [1,6-(13)C]glucose and [U-(13)C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices. Neurochemical research 20080801
Approaches to treatment of type 2 diabetes. Diabetes care 20080801
Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy. PLoS medicine 20080801
Tiagabine: let seizing dogs lie? Emergency medicine Australasia : EMA 20080801
Drug interactions between chemotherapeutic regimens and antiepileptics. Clinical therapeutics 20080801
Tiagabine: efficacy and safety in partial seizures - current status. Neuropsychiatric disease and treatment 20080801
Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure 20080701
Preoperative fMRI predicts memory decline following anterior temporal lobe resection. Journal of neurology, neurosurgery, and psychiatry 20080601
Short-term variations in response distribution to cortical stimulation. Brain : a journal of neurology 20080601
Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease. Neurobiology of disease 20080601
Tiagabine in adult patients with generalized anxiety disorder: results from 3 randomized, double-blind, placebo-controlled, parallel-group studies. Journal of clinical psychopharmacology 20080601
The search for medications to treat stimulant dependence. Addiction science & clinical practice 20080601
Acute and long-term treatment of mania. Dialogues in clinical neuroscience 20080601
Promising avenues of therapeutics for bipolar illness. Dialogues in clinical neuroscience 20080601
New treatments for cocaine dependence: a focused review. The international journal of neuropsychopharmacology 20080501
Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures. Journal of neural transmission (Vienna, Austria : 1996) 20080501
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats. Psychopharmacology 20080501
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. Current neurovascular research 20080501
Anticonvulsants for cocaine dependence. The Cochrane database of systematic reviews 20080416
Seizure-freedom with combination therapy in localization-related epilepsy. Seizure 20080401
Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats. Progress in neuro-psychopharmacology & biological psychiatry 20080401
Clinical picture of EPM1-Unverricht-Lundborg disease. Epilepsia 20080401
Effects of acute tiagabine administration on aggressive responses of adult male parolees. Journal of psychopharmacology (Oxford, England) 20080301
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC). Epilepsy research 20080301
Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. Pharmacopsychiatry 20080301
Pregnancy, epilepsy, and anticonvulsants. Dialogues in clinical neuroscience 20080301
The effectiveness of anticonvulsants in psychiatric disorders. Dialogues in clinical neuroscience 20080301
Hypoalgesia in mice lacking GABA transporter subtype 1. Journal of neuroscience research 20080201
Inhibition of human aromatase complex (CYP19) by antiepileptic drugs. Toxicology in vitro : an international journal published in association with BIBRA 20080201
A review of ramelteon in the treatment of sleep disorders. Neuropsychiatric disease and treatment 20080201
Monotherapy for partial epilepsy: focus on levetiracetam. Neuropsychiatric disease and treatment 20080201
Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS drugs 20080101
Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide. Arzneimittel-Forschung 20080101
Status epilepticus due to tiagabine ingestion. American journal of therapeutics 20080101
Use of second-generation antiepileptic drugs in the pediatric population. Paediatric drugs 20080101
Depressive symptoms in epilepsy: prevalence, impact, aetiology, biological correlates and effect of treatment with antiepileptic drugs. Drugs 20080101
Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling. PloS one 20080101
Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence. The American journal of drug and alcohol abuse 20080101
GABI-balance--a non-interventional observational study on the effectiveness of tiagabine in add-on therapy in partial epilepsy. Neurologia i neurochirurgia polska 20080101
Seizure control in patients with epilepsy: the physician vs. medication factors. BMC health services research 20080101
[Endocrine effects of antiepileptic drugs]. Przeglad lekarski 20080101
[Effects of antiepileptic drugs on immune system]. Przeglad lekarski 20080101
Effects of new antiepileptic drugs and progabide on the mitogen-induced proliferative activity of mouse splenocytes. Pharmacological reports : PR 20080101
Effect of cocaine on responsiveness of alpha(1)-adrenergic receptors in rat cerebral cortex: modulation by GABA-mimetic drugs. Pharmacological reports : PR 20080101
Ocular adverse effects of Topiramate: Two case reports. Indian journal of pharmacology 20080101
[Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame]. Der Nervenarzt 20071201
A double-blind, placebo-controlled trial of tiagabine for the treatment of cocaine dependence. Drug and alcohol dependence 20071201
Deliberate self-poisoning with tiagabine: an unusual toxidrome. Emergency medicine Australasia : EMA 20071201
Therapeutic options and challenges for substances of abuse. Dialogues in clinical neuroscience 20071201
Management of epilepsy in the elderly. Neuropsychiatric disease and treatment 20071201
Treatment of drop attacks in Coffin-Lowry syndrome with the use of sodium oxybate. Pediatric neurology 20071101
Tiagabine and exacerbation of essential tremor. Movement disorders : official journal of the Movement Disorder Society 20071031
Neurochemical regulation of sleep. Journal of psychiatric research 20071001
Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice. Seizure 20071001
Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1. Biochemical and biophysical research communications 20070921
[Rational combination therapy in epilepsy. II. Clinical and pharmacological aspects]. Revista de neurologia 20070801
Antiepileptic drugs for the treatment of post-traumatic stress disorder. Current psychiatry reports 20070801
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons. Drug and alcohol dependence 20070710
Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070701
Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors. Bioorganic & medicinal chemistry letters 20070701
Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs. Epilepsia 20070701
Tiagabine for social anxiety disorder. Human psychopharmacology 20070601
The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. Journal of clinical psychopharmacology 20070601
New developments in the pharmacotherapy of cocaine abuse. Addiction biology 20070601
Status gelasticus associated with levetiracetam as add-on treatment. Epileptic disorders : international epilepsy journal with videotape 20070601
Antiepileptic drugs and visual function. Pediatric neurology 20070601
Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology 20070515
Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats. Psychopharmacology 20070501
Tiagabine does not attenuate alcohol-induced activation of the human reward system. Psychopharmacology 20070501
A new look at the second-generation antiepileptic drugs: a decade of experience. The neurologist 20070501
Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. The European journal of neuroscience 20070501
Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats. Neuroscience letters 20070406
New therapies for ataxia-telangiectasia. Archives of neurology 20070401
Tiagabine-induced non-convulsive status epilepticus in a patient without history of epilepsy. Neurosciences (Riyadh, Saudi Arabia) 20070401
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. Progress in neuro-psychopharmacology & biological psychiatry 20070330
Topiramate reduces ethanol consumption by C57BL/6 mice. Synapse (New York, N.Y.) 20070301
Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study. Neuropharmacology 20070301
Anticonvulsants in sports: ethical considerations. Epilepsy & behavior : E&B 20070301
Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability. Epilepsy & behavior : E&B 20070301
Depression in epilepsy: phenomenology, diagnosis and management. Epileptic disorders : international epilepsy journal with videotape 20070301
Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. Drug and alcohol dependence 20070223
Reduced aggression in mice lacking GABA transporter subtype 1. Journal of neuroscience research 20070215
Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy. Epilepsy & behavior : E&B 20070201
Effects of antiepileptic drugs on learning as assessed by a repeated acquisition of response sequences task in rats. Epilepsy & behavior : E&B 20070201
The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. Journal of clinical psychopharmacology 20070201
Tiagabine-induced myoclonic status epilepticus in a nonepileptic patient. Neurology 20070123
Novel anticonvulsant drugs. Pharmacology & therapeutics 20070101
High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochemistry international 20070101
Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII). Epilepsy research 20070101
Targets for antiepileptic drugs in the synapse. Medical science monitor : international medical journal of experimental and clinical research 20070101
Discovery of antiepileptic drugs. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101
Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101
Suicidality and antiepileptic drugs: is there a link? Drug safety 20070101
Current approaches to the pharmacologic treatment of anxiety disorders. Psychopharmacology bulletin 20070101
Second-generation antiepileptic drugs' impact on balance: a meta-analysis. Mayo Clinic proceedings 20070101
Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium. Clinical pharmacokinetics 20070101
Pharmacotherapy of dual substance abuse and dependence. CNS drugs 20070101
An open-label study to evaluate switching from an SSRI or SNRI to tiagabine to alleviate antidepressant-induced sexual dysfunction in generalized anxiety disorder. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20070101
Neurobiology of memory and anxiety: from genes to behavior. Neural plasticity 20070101
Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug safety 20070101
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat. BMC neuroscience 20070101
Influence of tiagabine on the antinociceptive action of morphine, metamizole and indomethacin in mice. Acta poloniae pharmaceutica 20070101
[Tiagabine overdose--report of two cases]. Przeglad lekarski 20070101
Is tiagabine helpful in generalized anxiety disorder? Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20070101
Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetrazole-induced clonic seizures in mice. Pharmacological reports : PR 20070101
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research. BMC genetics 20070101
An open-label study of tiagabine in panic disorder. Psychopharmacology bulletin 20070101
Effects of some new antiepileptic drugs and progabide on glucocorticoid receptor-mediated gene transcription in LMCAT cells. Pharmacological reports : PR 20070101
[New hypnotics: perspectives from sleep physiology]. Vertex (Buenos Aires, Argentina) 20070101
[Caffeine and antiepileptic drugs: experimental and clinical data]. Przeglad lekarski 20070101
Optimizing therapy of seizures in women who use oral contraceptives. Neurology 20061226
The ethics of excluding women who become pregnant while participating in clinical trials of anti-epileptic medications. Seizure 20061201
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice. Inflammopharmacology 20061201
Seizures in a pediatric patient with a tiagabine overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20061201
Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatric disease and treatment 20061201
Tiagabine-induced nonconvulsive status epilepticus in an adolescent without epilepsy. Neurology 20061024
[Adult-onset ataxia-telangiectasia. A clinical and therapeutic observation]. Neurologia (Barcelona, Spain) 20061001
Tiagabine in anxiety disorders. Expert opinion on pharmacotherapy 20061001
Effect of the administration of tiagabine and gabapentin on rabbit electroencephalogram activity. The Journal of pharmacy and pharmacology 20061001
Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice. The European journal of neuroscience 20061001
Comparison of the efficacy and tolerability of new antiepileptic drugs: what can we learn from long-term studies? Acta neurologica Scandinavica 20060901
Tiagabine withdrawal-emergent mania. The Australian and New Zealand journal of psychiatry 20060801
Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability. The Cochrane database of systematic reviews 20060719
Tiagabine in the maintenance treatment of bipolar disorders. The Cochrane database of systematic reviews 20060719
Enhancement of brain kynurenic acid production by anticonvulsants--novel mechanism of antiepileptic activity? European journal of pharmacology 20060717
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization. European journal of pharmacology 20060717
Comparison of the cognitive effects of tiagabine and carbamazepine as monotherapy in newly diagnosed adult patients with partial epilepsy: pooled analysis of two long-term, randomized, follow-up studies. Epilepsia 20060701
Tiagabine and vigabatrin reduce the severity of NMDA-induced excitotoxicity in chick retina. Experimental brain research 20060601
Long-term effects of tiagabine monotherapy on cognition and mood in adult patients with chronic partial epilepsy. Epilepsy & behavior : E&B 20060601
The use of tiagabine in pediatric spasticity management. Developmental medicine and child neurology 20060601
Age-correlated decline in [3H]tiagabine binding to GAT-1 in human frontal cortex. Aging clinical and experimental research 20060601
Cognitive Effects of Low-dose Topiramate Compared with Oxcarbazepine in Epilepsy Patients. Journal of clinical neurology (Seoul, Korea) 20060601
Pregabalin exerts oppositional effects on different inhibitory circuits in human motor cortex: a double-blind, placebo-controlled transcranial magnetic stimulation study. Epilepsia 20060501
Transient athetosis induced by tiagabine. Epilepsia 20060401
Tiagabine is associated with sustained attention during sleep restriction: evidence for the value of slow-wave sleep enhancement? Sleep 20060401
Tiagabine enhances slow wave sleep and sleep maintenance in primary insomnia. Sleep medicine 20060301
Clinically relevant drug interactions with antiepileptic drugs. British journal of clinical pharmacology 20060301
Anticonvulsants in the treatment of bipolar mania. Expert opinion on pharmacotherapy 20060301
Emerging pharmacological strategies in the fight against cocaine addiction. Expert opinion on emerging drugs 20060301
The clinical effectiveness and cost-effectiveness of newer drugs for children with epilepsy. A systematic review. Health technology assessment (Winchester, England) 20060301
Effect of tiagabine on sleep in elderly subjects with primary insomnia: a randomized, double-blind, placebo-controlled study. Sleep 20060301
Seizure activity and off-label use of tiagabine. The New England journal of medicine 20060216
Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20060115
Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I). Bioorganic & medicinal chemistry letters 20060101
Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology 20060101
Neurotransmitter transporters and their impact on the development of psychopharmacology. British journal of pharmacology 20060101
Open-label tiagabine monotherapy for major depressive disorder with anxiety. The Journal of clinical psychiatry 20060101
Interactions between antiepileptic and antipsychotic drugs. Drug safety 20060101
Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age. Clinical pharmacokinetics 20060101
Glial modulation of GABAergic and glutamat ergic neurotransmission. Current topics in medicinal chemistry 20060101
Intrahemispheric dysfunction in primary motor cortex without corpus callosum: a transcranial magnetic stimulation study. BMC neurology 20060101
Structure-activity relationships of selective GABA uptake inhibitors. Current topics in medicinal chemistry 20060101
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clinical pharmacokinetics 20060101
Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors. Advances in pharmacology (San Diego, Calif.) 20060101
A comparative study on the cost of new antibiotics and drugs of other therapeutic categories. PloS one 20060101
Effect of combined administration of ethanol and tiagabine on rabbit EEG. Pharmacological reports : PR 20060101
Effects of GABAergic modulators on food and cocaine self-administration in baboons. Drug and alcohol dependence 20051212
Effects of antiepileptic drugs on attention as assessed by a five-choice serial reaction time task in rats. Epilepsy & behavior : E&B 20051201
Color vision and contrast sensitivity in epilepsy patients treated with initial tiagabine monotherapy. Epilepsy research 20051201
Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction. European journal of clinical pharmacology 20051201
Pharmacokinetic variability of new antiepileptic drugs at different ages. Therapeutic drug monitoring 20051201
The pharmacokinetics and interactions of new antiepileptic drugs: an overview. Therapeutic drug monitoring 20051201
Sleep and psychiatry. Dialogues in clinical neuroscience 20051201
Sleep disturbances, psychiatric disorders, and psychotropic drugs. Dialogues in clinical neuroscience 20051201
A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal. Journal of psychoactive drugs 20051201
New medications for the treatment of cocaine dependence. Psychiatry (Edgmont (Pa. : Township)) 20051201
Tiagabine affects the subjective responses to cocaine in humans. Pharmacology, biochemistry, and behavior 20051101
The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. The Journal of clinical psychiatry 20051101
Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant. European journal of pharmacology 20051003
Medications development: successes and challenges. Pharmacology & therapeutics 20051001
Status epilepticus and tiagabine therapy revisited. Epilepsia 20051001
Recent pharmacologic updates. Journal of child and adolescent psychopharmacology 20051001
Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers. Psychopharmacology 20050901
Control of refractory status epilepticus precipitated by anticonvulsant withdrawal using left vagal nerve stimulation: a case report. Surgical neurology 20050801
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Naunyn-Schmiedeberg's archives of pharmacology 20050701
Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimens. Synapse (New York, N.Y.) 20050601
Pharmacological and histological characterisation of nicotine-kindled seizures in mice. Neuropharmacology 20050601
Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats. Neuropharmacology 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Dose-response effects of tiagabine on the sleep of older adults. Sleep 20050601
Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy & behavior : E&B 20050501
Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder. Journal of psychiatry & neuroscience : JPN 20050501
Pharmacotherapy and other treatments for cocaine abuse and dependence. Current opinion in psychiatry 20050501
Tiagabine for treatment of bipolar disorder with severe anxiety. Psychiatry (Edgmont (Pa. : Township)) 20050501
Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health technology assessment (Winchester, England) 20050401
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323
Tiagabine as add-on therapy may be more effective with valproic acid--open label, multicentre study of patients with focal epilepsy. European journal of neurology 20050301
A randomised open-label study of tiagabine given two or three times daily in refractory epilepsy. Seizure 20050301
A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments. Addiction (Abingdon, England) 20050301
Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned. Addiction (Abingdon, England) 20050301
Cocaine Rapid Efficacy Screening Trial (CREST): a paradigm for the controlled evaluation of candidate medications for cocaine dependence. Addiction (Abingdon, England) 20050301
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. The Journal of pharmacology and experimental therapeutics 20050201
Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050201
Trauma, resilience and saliostasis: effects of treatment in post-traumatic stress disorder. International clinical psychopharmacology 20050101
Preliminary study on the efficacy and tolerability of newer anticonvulsants in a population of epileptic patients. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101
Mechanisms of action of antiepileptic drugs. Current topics in medicinal chemistry 20050101
Novel approaches to the treatment of cocaine addiction. CNS drugs 20050101
Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsy. Clinical neuropharmacology 20050101
Antiepileptic action induced by a combination of vigabatrin and tiagabine. Neuroscience 20050101
Bipolar mixed states and their treatment. Expert review of neurotherapeutics 20050101
Bupropion-induced convulsions: preclinical evaluation of antiepileptic drugs. Epilepsy research 20050101
Tiagabine for rage, aggression, and anxiety. The Journal of neuropsychiatry and clinical neurosciences 20050101
Tiagabine and gabapentin for the management of chronic pain. The Clinical journal of pain 20050101
Antiepileptic drugs in mood-disordered patients. Epilepsia 20050101
Ion channels and epilepsy. Current pharmaceutical design 20050101
New antiepileptic drugs--an overview. Roczniki Akademii Medycznej w Bialymstoku (1995) 20050101
Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers. Neuropsychobiology 20050101
Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats. Epilepsy research 20050101
Tiagabine may reduce bruxism and associated temporomandibular joint pain. Anesthesia progress 20050101
Practical management issues for idiopathic generalized epilepsies. Epilepsia 20050101
Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat. Cerebellum (London, England) 20050101
[GEOS (Gabitril Epilepsy Observational Study) -- Polish results of the international study of tiagabine in partial epilepsy]. Neurologia i neurochirurgia polska 20050101
Role of opioidergic mechanisms and GABA uptake inhibition in the heroin-induced discriminative stimulus effects in rats. Pharmacological reports : PR 20050101
An open-label study of tiagabine as augmentation therapy for anxiety. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20050101
Retrospective evaluation of tiagabine overdose. Clinical toxicology (Philadelphia, Pa.) 20050101
Tiagabine overdose: a case of status epilepticus in a non-epileptic patient. Clinical toxicology (Philadelphia, Pa.) 20050101
[Current pharmacotherapy of epilepsy in adults]. Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg 20050101
The pharmacokinetic inter-relationship of tiagabine in blood, cerebrospinal fluid and brain extracellular fluid (frontal cortex and hippocampus). Seizure 20041201
Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats. Epilepsy & behavior : E&B 20041201
Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. Journal of medicinal chemistry 20041104
Fracture risk associated with use of antiepileptic drugs. Epilepsia 20041101
GABA transporters as drug targets for modulation of GABAergic activity. Biochemical pharmacology 20041015
Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans. Drug and alcohol dependence 20041005
Treating refractory epilepsy with tiagabine: clinical experience. Seizure 20041001
Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. The Lancet. Neurology 20041001
Intentional overdose with tiagabine: an unusual clinical presentation. The Journal of emergency medicine 20041001
Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model. The European journal of neuroscience 20041001
[Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update]. Neurologia (Barcelona, Spain) 20041001
Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro. The Journal of physiology 20040915
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. Epilepsia 20040901
Vigabatrin and tiagabine might have antipanic properties. Journal of psychopharmacology (Oxford, England) 20040901
Drug selection for the newly diagnosed patient: when is a new generation antiepileptic drug indicated? Journal of neurology 20040901
Side effects of antiepileptics--a review. Pain practice : the official journal of World Institute of Pain 20040901
GABAergic neurotransmission in globus pallidus and its involvement in neurologic disorders. Sheng li xue bao : [Acta physiologica Sinica] 20040825
Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure 20040701
[Anticonvulsant hypersensitivity syndrome with severe repercussions in the skin and kidneys due to carbamazepine]. Revista de neurologia 20040601
[Treatment protocol for long-term anti-epilepsy drugs in adults with refractory partial epilepsy]. Revue neurologique 20040601
New pharmacotherapies for pediatric seizures. Pediatric annals 20040601
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 20040501
Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 20040501
Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat. Epilepsia 20040501
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 20040427
Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 20040427
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study. Naunyn-Schmiedeberg's archives of pharmacology 20040401
Understanding co-morbidities affecting children with epilepsy. Neurology 20040309
Interaction between anticonvulsants and human placental carnitine transporter. Epilepsia 20040301
Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA. The Journal of clinical psychiatry 20040301
The effect of antiepileptic drugs on visual performance. Seizure 20040301
The new antiepileptic drugs: scientific review. JAMA 20040204
Mood effects of antiepileptic drugs. Epilepsy & behavior : E&B 20040201
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia. Stroke 20040201
Tiagabine for treating painful tonic spasms in multiple sclerosis: a pilot study. Journal of neurology, neurosurgery, and psychiatry 20040201
Behavioural effects of the newer antiepileptic drugs: an update. Expert opinion on drug safety 20040101
Treatment of partial seizures in childhood : an overview. CNS drugs 20040101
Electrophysiology and immunohistochemistry in the hippocampal ca1 and the dentate gyrus of rats chronically exposed to 1-bromopropane, a substitute for specific chlorofluorocarbons. Neuroscience 20040101
New antiepileptic agents. Pediatric dentistry 20040101
GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizures. Journal of biomedical science 20040101
Effect of topiramate on mechanical allodynia in neuropathic pain model in rats. Polish journal of pharmacology 20040101
Agents in development for the management of cocaine abuse. Drugs 20040101
Newer anticonvulsants in the treatment of bipolar disorder. The Journal of clinical psychiatry 20040101
Antiepileptic drugs in migraine prophylaxis: state of the art. La Clinica terapeutica 20040101
Role of the GABA transporter in epilepsy. Advances in experimental medicine and biology 20040101
Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder. BMC psychiatry 20040101
[New molecular targets in pharmacological treatment of anxiety disorders]. Vertex (Buenos Aires, Argentina) 20040101
Low-dose tiagabine effectiveness in anxiety disorders. MedGenMed : Medscape general medicine 20040101
Therapeutic drug monitoring of old and newer anti-epileptic drugs. Clinical chemistry and laboratory medicine 20040101
[Neuroprotective activity of antiepileptic drugs]. Przeglad lekarski 20040101
Non-convulsive status epilepticus associated with tiagabine therapy in children. Seizure 20031201
Tiagabine for posttraumatic stress disorder: a case series of 7 women. The Journal of clinical psychiatry 20031201
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer 20031117
Stereochemistry in clinical medicine: a neurological perspective. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20031101
Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. Addiction (Abingdon, England) 20031101
Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro. Epilepsia 20031101
Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001
Non-convulsive status epilepticus associated with tiagabine in a pediatric patient. Brain & development 20031001
Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat. Behavioral neuroscience 20031001
[Clinical and neurochemical aspects of diaphragmatic myoclonus]. Neurologia (Barcelona, Spain) 20031001
Tiagabine for the treatment of generalized anxiety disorder: a randomized, open-label, clinical trial with paroxetine as a positive control. The Journal of clinical psychiatry 20031001
Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Experimental brain research 20030901
Nonconvulsive status epilepticus due to a de novo contralateral focus during tiagabine adjunctive therapy. Seizure 20030701
[Significance of GABAA receptors for the pathophysiology and therapy of panic disorders]. Der Nervenarzt 20030701
Therapeutic drug monitoring of the newer antiepileptic drugs. Therapeutic drug monitoring 20030601
Clinical and EEG findings in six patients with altered mental status receiving tiagabine therapy. Epilepsy & behavior : E&B 20030601
Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. The Lancet. Neurology 20030601
GABA-ergic drugs: exit stage left, enter stage right. Journal of psychopharmacology (Oxford, England) 20030601
Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice. Pharmacology, biochemistry, and behavior 20030501
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? Epileptic disorders : international epilepsy journal with videotape 20030501
Altered gene expression in frontal cortex and midbrain of 3,4-methylenedioxymethamphetamine (MDMA) treated mice: differential regulation of GABA transporter subtypes. Journal of neuroscience research 20030415
[New epileptic treatments. Current modalities and their utilization]. Presse medicale (Paris, France : 1983) 20030308
Vigabatrin, tiagabine, and visual fields. Journal of neurology, neurosurgery, and psychiatry 20030301
A controlled study comparing visual function in patients treated with vigabatrin and tiagabine. Journal of neurology, neurosurgery, and psychiatry 20030301
Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction. Epilepsia 20030301
Therapeutics in pediatric epilepsy, Part 1: The new antiepileptic drugs and the ketogenic diet. Mayo Clinic proceedings 20030301
Review of the newer antiepileptic drugs. The American journal of managed care 20030301
Treating bipolar depression. The Journal of family practice 20030301
Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine. Epileptic disorders : international epilepsy journal with videotape 20030301
Glutamate modulation of GABA transport in retinal horizontal cells of the skate. The Journal of physiology 20030201
Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate. Neurochemical research 20030201
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation. Neuroscience letters 20030102
Stability of tiagabine in two oral liquid vehicles. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030101
Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus. Epilepsy research 20030101
Interlaboratory variability in the quantification of new generation antiepileptic drugs based on external quality assessment data. Epilepsia 20030101
The role of GABA in anxiety disorders. The Journal of clinical psychiatry 20030101
GABA systems, benzodiazepines, and substance dependence. The Journal of clinical psychiatry 20030101
Selection criteria for the clinical use of the newer antiepileptic drugs. CNS drugs 20030101
Concurrent use of antiretrovirals and anticonvulsants in human immunodeficiency virus (HIV) seropositive patients. Current pharmaceutical design 20030101
Clinical care of pregnant women with epilepsy: neural tube defects and folic acid supplementation. Epilepsia 20030101
Newer antiepileptic drugs and cognitive issues. Epilepsia 20030101
Do antiepileptic drugs play a role in sudden unexpected death in epilepsy? Drug safety 20030101
Efficacy of newer anticonvulsant medications in bipolar spectrum mood disorders. The Journal of clinical psychiatry 20030101
Tiagabine for the treatment of anxiety. Depression and anxiety 20030101
An in vitro study of new antiepileptic drugs and astrocytes. Epilepsia 20030101
[Determinants of tiagabine (TGB) efficacy and safety. A Polish multicenter study of 1307 patients with focal epilepsy]. Neurologia i neurochirurgia polska 20030101
Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers. Depression and anxiety 20030101
The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacology bulletin 20030101
The evolution of antiepileptic drugs for mood stabilization and their main mechanisms of action. Expert review of neurotherapeutics 20030101
Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices. Epilepsia 20021201
Antiepileptic drug therapy for adults: when to initiate and how to choose. Mayo Clinic proceedings 20021201
Relevance of new and newly rediscovered anticonvulsants for atypical forms of bipolar disorder. Journal of affective disorders 20021201
Tolerability of tiagabine: a prospective open-label study. Epileptic disorders : international epilepsy journal with videotape 20021201
New anticonvulsants: a review of applications for the management of substance abuse disorders. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201
New antiepileptic drug therapies. Neurologic clinics 20021101
Treatment of posttraumatic stress disorder with tiagabine. Canadian journal of psychiatry. Revue canadienne de psychiatrie 20021001
Tiagabine in treatment refractory bipolar disorder: a clinical case series. Bipolar disorders 20021001
Antiepileptic drug use during the first 12 months of vagus nerve stimulation therapy: a registry study. Neurology 20020924
Use of anticonvulsants for treatment of neuropathic pain. Neurology 20020910
New antiepileptic drugs in childhood. Panminerva medica 20020901
[(3)H]Tiagabine binding to GABA transporter-1 (GAT-1) in suicidal depression. Journal of affective disorders 20020901
An open case series on the utility of tiagabine as an augmentation in refractory bipolar outpatients. Journal of affective disorders 20020901
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. The Journal of pharmacology and experimental therapeutics 20020901
Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901
Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI). Epilepsy research 20020901
[Characteristics and indications of tiagabine]. Revista de neurologia 20020901
[Monitoring serum levels of new antiepileptics]. Revista de neurologia 20020901
Selective suppression of hippocampal region hyperexcitability related to seizure susceptibility in epileptic El mice by the GABA-transporter inhibitor tiagabine. Brain research 20020830
Neuroprotective effect of tiagabine in transient forebrain global ischemia: an in vivo microdialysis, behavioral, and histological study. Brain research 20020816
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs. The Journal of pharmacology and experimental therapeutics 20020801
[Antiepileptics]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020801
Tiagabine, a gamma-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze. Behavioural brain research 20020718
Aggravation of partial seizures by antiepileptic drugs: is there evidence from clinical trials? Neurology 20020709
Tiagabine overdose can induce convulsive status epilepticus. Epilepsia 20020701
Tiagabine-related non-convulsive status epilepticus in partial epilepsy: three case reports and a review of the literature. Seizure 20020601
Effects of antiepileptic drugs on visual function, with special reference to Vigabatrin. Acta ophthalmologica Scandinavica 20020601
Effects of tiagabine, a gamma-aminobutyric acid re-uptake inhibitor, on normal rat bladder function. The Journal of urology 20020501
Contribution of GABAergic cortical circuitry in shaping somatosensory evoked scalp responses: specific changes after single-dose administration of tiagabine. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20020501
[New antiepileptic drugs: new therapeutic options]. Revue neurologique 20020501
Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats. Journal of neural transmission (Vienna, Austria : 1996) 20020501
The importance of drug interactions in epilepsy therapy. Epilepsia 20020401
Occurrence of psychosis in patients with epilepsy randomized to tiagabine or placebo treatment. Epilepsia 20020401
Free-choice ethanol consumption under the influence of GABAergic drugs in rats. Alcoholism, clinical and experimental research 20020401
Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations. The Journal of clinical psychiatry 20020401
The 'number needed to treat' with levetiracetam (LEV): comparison with the other new antiepileptic drugs (AEDs). Seizure 20020401
[Adult GM2 gangliosidosis: improvement of ataxia with GABAergic drugs]. Neurologia (Barcelona, Spain) 20020301
Visual field defects. Seizure 20020301
Tiagabine in glial tumors. Epilepsy research 20020301
Recurrent complex partial status epilepticus associated with tiagabine rechallenge. Acta neurologica Belgica 20020301
Some common issues in the use of antiepileptic drugs. Seminars in neurology 20020301
New antiepileptic drugs. The neurologist 20020301
Marketed new antiepileptic drugs: are they better than old-generation agents? Therapeutic drug monitoring 20020201
New antiepileptic drugs: review on drug interactions. Therapeutic drug monitoring 20020201
Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1. British journal of pharmacology 20020101
Increased [(3)H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia. Neuropsychobiology 20020101
Appropriate use of medications for seizures. Guiding principles on the path of efficacy. Postgraduate medicine 20020101
The use of tiagabine in affective disorders. Pharmacopsychiatry 20020101
Seizures in HIV-seropositive individuals: epidemiology and treatment. CNS drugs 20020101
Anticonvulsants: aspects of their mechanisms of action. European journal of pain (London, England) 20020101
Non-convulsive status epilepticus induced by tiagabine in a patient with pseudoseizure. Seizure 20020101
Effect of antiepileptic drugs on cognitive function in individuals with epilepsy: a comparative review of newer versus older agents. Drugs 20020101
Effects of tiagabine and diazepam on operant ethanol self-administration in the rat. Journal of studies on alcohol 20020101
Interactions between antiepileptic drugs and hormonal contraception. CNS drugs 20020101
Cellular mechanisms of pharmacoresistance in slices from epilepsy surgery. Novartis Foundation symposium 20020101
Mood disorders in patients with epilepsy: epidemiology and management. CNS drugs 20020101
Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations. Clinical pharmacokinetics 20020101
Tiagabine add-on for drug-resistant partial epilepsy. The Cochrane database of systematic reviews 20020101
New and emerging prophylactic agents for migraine. CNS drugs 20020101
The use of tiagabine augmentation for treatment-resistant anxiety disorders: a case series. Psychopharmacology bulletin 20020101
Pharmacokinetics of mood stabilizers and new anticonvulsants. Psychopharmacology bulletin 20020101
Rat models of genetic absence epilepsy: what do EEG spike-wave discharges tell us about drug effects? Methods and findings in experimental and clinical pharmacology 20020101
New migraine preventive options: an update with pathophysiological considerations. Revista do Hospital das Clinicas 20020101
Action of 4-amino-2-fluorobutanoic acid and other structural analogues on gamma-aminobutyric acid transport by channel catfish brain. Journal of basic and clinical physiology and pharmacology 20020101
Neuroprotective effects of antiepileptic drugs. Polish journal of pharmacology 20020101
Effectiveness of adjunctive therapy with tiagabine in mentally disabled patients with epilepsy. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20020101
Newer anticonvulsant drugs in neuropathic pain and bipolar disorder. Journal of pain & palliative care pharmacotherapy 20020101
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy research 20011201
Treatment of painful sensory neuropathy with tiagabine: a pilot study. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20011201
Clinical pharmacology and therapeutic use of the new antiepileptic drugs. Fundamental & clinical pharmacology 20011201
[Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20011201
Review of treatment options for refractory epilepsy: new medications and vagal nerve stimulation. Epilepsy research 20011101
[Experience with tiagabine in the clinical practice; new insights as to the efficacy and safety profile]. Der Nervenarzt 20011001
Visual fields and tiagabine: a quandary. Seizure 20011001
Drug-induced nonconvulsive status epilepticus with low dose of tiagabine. Epileptic disorders : international epilepsy journal with videotape 20010901
Newer antiepileptic drugs: advantages and disadvantages. Brain & development 20010801
Tiagabine improves panic and agoraphobia in panic disorder patients. The Journal of clinical psychiatry 20010801
Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina. Neurology 20010724
Improvement of stiff-person syndrome with tiagabine. Neurology 20010724
Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. European journal of pharmacology 20010713
Advances in the treatment of epilepsy. American family physician 20010701
Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria. Pharmacology & toxicology 20010701
Transient dystonias in three patients treated with tiagabine. Epilepsia 20010701
Tiagabine treatment and DNA damage in rat astrocytes: an in vitro study by comet assay. Neuroscience letters 20010622
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors. Journal of medicinal chemistry 20010621
Efficacy of background GABA uptake in rat hippocampal slices. Neuroreport 20010613
Tiagabine, a specific gamma-aminobutyric acid transporter-1 inhibitor, in the treatment of psychosis. Journal of clinical psychopharmacology 20010601
Comparison of twice- and three times daily tiagabine for the adjunctive treatment of partial seizures in refractory patients with epilepsy: an open label, randomised, parallel-group study. Epileptic disorders : international epilepsy journal with videotape 20010601
[An open study of tiagabine in partial epilepsy]. Revista de neurologia 20010601
Tiagabine: efficacy and safety in adjunctive treatment of partial seizures. Epilepsia 20010401
Second generation anticonvulsant medications: their use in children. The Journal of school nursing : the official publication of the National Association of School Nurses 20010401
Status epilepticus and tiagabine therapy: review of safety data and epidemiologic comparisons. Epilepsia 20010301
Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. Journal of the Association for Research in Otolaryngology : JARO 20010301
Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using 13C magnetic resonance spectroscopy. Journal of neuroscience research 20010215
Localization and pharmacological characterization of voltage dependent calcium channels in cultured neocortical neurons. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20010201
Non-convulsive status epilepticus in two patients receiving tiagabine add-on treatment. Journal of neurology 20010201
[Antiepileptic drugs and neuropathic pain]. Revista de neurologia 20010201
Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V). Epilepsy research 20010101
The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects. Neurobiology of aging 20010101
[Controversies about the new anti-epileptic drugs]. Revista de neurologia 20010101
Pharmacology and clinical experience with tiagabine. Expert opinion on pharmacotherapy 20010101
Pharmacologic management of epilepsy in the elderly. Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 20010101
Effects of antiepileptic drugs on cognition. Epilepsia 20010101
Behavioural effects of the new anticonvulsants. Drug safety 20010101
Antiepileptogenic agents: how close are we? Drugs 20010101
The new generation of GABA enhancers. Potential in the treatment of epilepsy. CNS drugs 20010101
GABAergic mechanisms in epilepsy. Epilepsia 20010101
Epileptic encephalopathy. Epilepsia 20010101
Management strategies for refractory localization-related seizures. Epilepsia 20010101
The management of refractory idiopathic epilepsies. Epilepsia 20010101
Tiagabine in clinical practice. Epilepsia 20010101
Long-term safety of tiagabine. Epilepsia 20010101
Tiagabine (gabitril) experience in children. Epilepsia 20010101
Epilepsy in the elderly: the use of tiagabine. Epilepsia 20010101
The short-term impact of adjunctive tiagabine on health-related quality of life. Epilepsia 20010101
Antiepileptic drugs for the acute and maintenance treatment of bipolar disorder. Harvard review of psychiatry 20010101
Concerns with antiepileptic drug initiation: safety, tolerability, and efficacy. Epilepsia 20010101
[Social and economic aspects of administration of new antiepileptic drugs]. Neurologia i neurochirurgia polska 20010101
Ethical dilemmas of potential adverse events. Medicine and law 20010101
Developments in mood stabilisers. British medical bulletin 20010101
[Hormonal contraception and epilepsy]. Akusherstvo i ginekologiia 20010101
[New antiepileptic drugs in childhood epilepsies: indications and limits]. Epileptic disorders : international epilepsy journal with videotape 20010101
Clinical evaluation of Gabitril and Lamictal for drug-resistant epilepsy in adults. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20010101
Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure 20000601
Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. The Journal of pharmacology and experimental therapeutics 19990901
Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria. Neurology 19970701
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. British journal of pharmacology 19970301
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. European journal of pharmacology 19941014
Tiagabine inhibits haloperidol-induced oral dyskinesias in rats. Journal of neural transmission. General section 19940101
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