Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Toxicological sciences : an official journal of the Society of Toxicology 20150601

Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes.

Toxicological sciences : an official journal of the Society of Toxicology 20150601

Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20150501

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.

Biochemical pharmacology 20140915

Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.

PloS one 20140101

Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

Toxicological sciences : an official journal of the Society of Toxicology 20131201

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology 20131101

Transcellular transport of aconitine across human intestinal Caco-2 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130701

Multidrug resistance protein 1 (ABCC1) confers resistance to arsenic compounds in human myeloid leukemic HL-60 cells.

Archives of toxicology 20130601

Arsenate accumulation and arsenate-induced glutathione export in astrocyte-rich primary cultures.

Neurochemistry international 20130601

The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells.

Toxicology letters 20130204

Absorption mechanism of ginsenoside compound K and its butyl and octyl ester prodrugs in Caco-2 cells.

Journal of agricultural and food chemistry 20121017

Characterization of efflux transport of the PDE5 inhibitors, vardenafil and sildenafil.

The Journal of pharmacy and pharmacology 20120801

Fasitibant chloride, a kinin B₂ receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats.

British journal of pharmacology 20120601

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin.

European journal of pharmacology 20120415

The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.

Leukemia & lymphoma 20120401

A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.

Xenobiotica; the fate of foreign compounds in biological systems 20120201

Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.

The Journal of biological chemistry 20120102

The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes.

Journal of neurochemistry 20120101

Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

PloS one 20120101

ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium.

Cellular signalling 20111201

Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes.

Biochimica et biophysica acta 20111101

Development of a double-layer microfluidic chip with flow medium for chemotherapy resistance analysis of lung cancer.

Electrophoresis 20111101

Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells.

Chemical research in toxicology 20110815

Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.

Journal of the American College of Cardiology 20110809

Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20110601

Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110501

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.

Toxicological sciences : an official journal of the Society of Toxicology 20110401

Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.

Xenobiotica; the fate of foreign compounds in biological systems 20110401

Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats.

Biological chemistry 20110401

Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

Drug metabolism and disposition: the biological fate of chemicals 20110201

Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants.

Aquatic toxicology (Amsterdam, Netherlands) 20110117

Preclinical pharmacokinetics of PDE-310, a novel PDE4 inhibitor.

Drug metabolism and pharmacokinetics 20110101

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

Toxicological sciences : an official journal of the Society of Toxicology 20101201

Role of the multidrug resistance protein-1 (MRP1) for endothelial progenitor cell function and survival.

Journal of molecular and cellular cardiology 20100901

Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

International journal of pharmaceutics 20100816

Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters.

Biochemical pharmacology 20100815

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.

Journal of medicinal chemistry 20100812

cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter.

Molecular human reproduction 20100701

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy.

Neuropharmacology 20100601

MRP transporters as membrane machinery in the bradykinin-inducible export of ATP.

Naunyn-Schmiedeberg's archives of pharmacology 20100401

Multidrug resistance proteins restrain the intestinal absorption of trans-resveratrol in rats.

The Journal of nutrition 20100301

Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A.

Journal of pharmacological sciences 20100101

Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir.

Biological & pharmaceutical bulletin 20091201

ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites.

Toxicology letters 20091028

Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20091001

Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

Journal of medicinal chemistry 20090910

Inhibition of multidrug/xenobiotic resistance transporter by MK571 improves dye (Fura 2) accumulation in crustacean tissues from lobster, shrimp, and isopod.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090901

Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells.

Drug metabolism and disposition: the biological fate of chemicals 20090901

Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.

Journal of medicinal chemistry 20090813

Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes.

The Journal of biological chemistry 20090807

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

Pharmaceutical research 20090801

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

American journal of physiology. Gastrointestinal and liver physiology 20090801

The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090712

Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.

Pharmaceutical research 20090401

Saturation of multidrug-resistant protein 2 (mrp2/abcc2)-mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration.

Drug metabolism and disposition: the biological fate of chemicals 20090401

Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090401

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line.

Journal of neuroscience research 20090301

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.

Journal of medicinal chemistry 20090226

Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215

Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells.

Life sciences 20090213

CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides.

Toxicology letters 20090210

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes.

Chemical research in toxicology 20090101

Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments.

Molecular pharmaceutics 20090101

The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium.

Molecular pharmaceutics 20090101

Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides.

Molecular pharmaceutics 20090101

Avian renal proximal tubule epithelium urate secretion is mediated by Mrp4.

American journal of physiology. Regulatory, integrative and comparative physiology 20081201

Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer.

International journal of oncology 20081201

P-gp inhibition potential in cell-based models: which 'calculation' method is the most accurate?

The AAPS journal 20081201

A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines.

Leukemia 20081001

Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus.

American journal of physiology. Regulatory, integrative and comparative physiology 20081001

ABCC1: a gateway for pharmacological compounds to the ischaemic brain.

Brain : a journal of neurology 20081001

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal of medicinal chemistry 20080612

Application and limitation of inhibitors in drug-transporter interactions studies.

International journal of pharmaceutics 20080522

Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.

Biochemical pharmacology 20080415

Cysteinyl leukotrienes mediate the enhancing effects of indomethacin and aspirin on eosinophil production in murine bone marrow cultures.

British journal of pharmacology 20080201

Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model.

European journal of pharmacology 20071201

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation.

The Journal of biological chemistry 20071019

Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20071001

ABCC transporter inhibition reduces zymosan-induced peritonitis.

Journal of leukocyte biology 20070901

Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system.

The European journal of neuroscience 20070901

Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.

Journal of pharmacological sciences 20070901

Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).

Drug metabolism and disposition: the biological fate of chemicals 20070801

Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor.

International journal of pharmaceutics 20070718

Mechanistic study on the intestinal absorption and disposition of baicalein.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters.

Toxicology letters 20070515

Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.

Drug metabolism and disposition: the biological fate of chemicals 20070501

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Current drug metabolism 20070501

Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.

Bioorganic & medicinal chemistry letters 20070215

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin.

Neuroscience 20070209

Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters.

British journal of pharmacology 20070201

Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells.

Experimental eye research 20070101

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.

The Journal of allergy and clinical immunology 20070101

Modulatory effects of heparin on cellular accumulation and cytotoxicity of doxorubicin in MRP1-overexpressing HL60/doxo cells.

Anticancer research 20070101

Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin.

Chemotherapy 20070101

Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles.

Molecular membrane biology 20070101

Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma.

Prostaglandins, leukotrienes, and essential fatty acids 20070101

Transport of antimony salts by Arabidopsis thaliana protoplasts over-expressing the human multidrug resistance-associated protein 1 (MRP1/ABCC1).

FEBS letters 20061222

An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.

Toxicology and applied pharmacology 20061201

Formation and rapid export of the monochlorobimane-glutathione conjugate in cultured rat astrocytes.

Neurochemical research 20061201

The complexity of intestinal absorption and exsorption of digoxin in rats.

International journal of pharmaceutics 20060928

The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2.

Pharmaceutical research 20060801

Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

Biopharmaceutics & drug disposition 20060701

The sea urchin embryo as a model for studying efflux transporters: roles and energy cost.

Marine environmental research 20060701

Molecular characterization and inhibition of amanitin uptake into human hepatocytes.

Toxicological sciences : an official journal of the Society of Toxicology 20060501

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis.

Journal of neurochemistry 20060501

Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.

Molecular pharmacology 20060401

The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes.

Journal of neurochemistry 20060401

Tritiated taurine handling by isolated rat pancreatic islets.

Endocrine 20060401

Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.

Archives of toxicology 20060301

Human T cell cytokine responses are dependent on multidrug resistance protein-1.

International immunology 20060301

In vivo and in vitro modulation of MDR molecules in murine thymocytes.

International immunopharmacology 20060201

Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells.

International journal of cancer 20060101

Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.

Journal of hypertension 20060101

Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.

Respiratory research 20060101

Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.

The Journal of experimental biology 20051201

Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery.

Clinical and experimental pharmacology & physiology 20051201

Interaction of progestins with the human multidrug resistance-associated protein 2 (MRP2).

Drug metabolism and disposition: the biological fate of chemicals 20051101

Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20051101

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

The FEBS journal 20050901

Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

Life sciences 20050826

Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

Biochemical pharmacology 20050815

Combined effects of GSTP1 and MRP1 in melanoma drug resistance.

British journal of cancer 20050725

Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Journal of pharmaceutical sciences 20050701

Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae.

Pharmaceutical research 20050701

Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.

Xenobiotica; the fate of foreign compounds in biological systems 20050701

Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system.

Life sciences 20050617

Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

The Journal of pharmacology and experimental therapeutics 20050501

Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

Immunology 20050401

P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice.

The Journal of pharmacology and experimental therapeutics 20050301

Catfish egg lectin causes rapid activation of multidrug resistance 1 P-glycoprotein as a lipid translocase.

Biological & pharmaceutical bulletin 20050301

Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers.

Bioscience, biotechnology, and biochemistry 20050301

MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice.

Toxicology and applied pharmacology 20050215

Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells.

Journal of agricultural and food chemistry 20050209

Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).

Molecular pharmacology 20050201

Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis.

Journal of immunology (Baltimore, Md. : 1950) 20050201

Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality.

Planta medica 20050201

Endogenous thiols and MRP transporters contribute to Hg2+ efflux in HgCl2-treated tubular MDCK cells.

Toxicology 20050105

Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.

Anticancer research 20050101

P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes.

International journal of immunopathology and pharmacology 20050101

Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin.

Biochemical pharmacology 20041201

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

British journal of pharmacology 20041201

The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin.

The Biochemical journal 20041015

Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001

Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040925

Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy.

American journal of physiology. Renal physiology 20040901

Disposition mechanisms of raloxifene in the human intestinal Caco-2 model.

The Journal of pharmacology and experimental therapeutics 20040701

The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.

Blood 20040601

Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines.

Leukemia research 20040601

Identification of multidrug resistance-associated protein 1 and glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine.

BJU international 20040601

Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.

Biochemical pharmacology 20040415

Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

The Journal of pharmacology and experimental therapeutics 20040401

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.

Biochemical pharmacology 20040101

Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.

Cellular oncology : the official journal of the International Society for Cellular Oncology 20040101

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

Chemical research in toxicology 20031201

Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis.

Biochemical and biophysical research communications 20031121

The beta-D-glucoside and sodium-dependent glucose transporter 1 (SGLT1)-inhibitor phloridzin is transported by both SGLT1 and multidrug resistance-associated proteins 1/2.

Drug metabolism and disposition: the biological fate of chemicals 20031101

The role of breast cancer resistance protein in acute lymphoblastic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research 20031101

Stereoselective hepatic disposition of a diastereomeric pair of alphavbeta3 antagonists in rat.

Xenobiotica; the fate of foreign compounds in biological systems 20031101

Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients.

Matrix biology : journal of the International Society for Matrix Biology 20031101

Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

Biochemical and biophysical research communications 20031010

Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.

American journal of physiology. Lung cellular and molecular physiology 20031001

Functional expression of the multidrug resistance protein 1 in microglia.

The Journal of pharmacology and experimental therapeutics 20031001

Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model.

The Journal of pharmacology and experimental therapeutics 20031001

Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells.

American journal of physiology. Gastrointestinal and liver physiology 20030901

cGMP and glutathione-conjugate transport in human erythrocytes.

European journal of biochemistry 20030901

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Molecular pharmacology 20030801

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

Hepatology (Baltimore, Md.) 20030801

Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells.

Pharmaceutical research 20030601

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.

Molecular pharmacology 20030501

Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030501

Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes.

American journal of physiology. Heart and circulatory physiology 20030401

Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13.

American journal of respiratory cell and molecular biology 20030401

Kinetic analysis of fluorescein and dihydrofluorescein effluxes in tumour cells expressing the multidrug resistance protein, MRP1.

Biochemical pharmacology 20030315

Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.

Journal of leukocyte biology 20030301

Sulfate conjugating and transport functions of MDCK distal tubular cells.

Kidney international 20030301

Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).

Molecular pharmacology 20030201

Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

European journal of pharmacology 20030110

Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

Chemico-biological interactions 20030106

Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.

The Biochemical journal 20030101

Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons.

The Journal of pharmacology and experimental therapeutics 20030101

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers.

European journal of pharmacology 20030101

Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.

European journal of pharmacology 20030101

Dehydrothyrsiferol does not modulate multidrug resistance-associated protein 1 resistance: a functional screening system for MRP1 substrates.

International journal of molecular medicine 20021101

A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.

Analytical biochemistry 20021101

Functional analysis of ABCA8, a new drug transporter.

Biochemical and biophysical research communications 20021018

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

Journal of cellular physiology 20020801

Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells.

Journal of neuroscience research 20020801

Mrp2 modulates the activity of chloride channels in isolated hepatocytes.

Hepatology (Baltimore, Md.) 20020701

Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6).

Biochemistry 20020625

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

Cancer research 20020601

Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.

The Journal of allergy and clinical immunology 20020601

Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes.

Biological chemistry 20020601

Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.

Drug metabolism and disposition: the biological fate of chemicals 20020501

Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.

International journal of cancer 20020220

5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.

Gastroenterology 20020201

Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma.

European journal of pharmacology 20020201

Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin-induced diabetic rats.

Arteriosclerosis, thrombosis, and vascular biology 20011101

Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.

Biochemical pharmacology 20011101

Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss.

American journal of physiology. Regulatory, integrative and comparative physiology 20011001

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

Cancer research 20011001

Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic.

Molecular pharmacology 20010801

An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea.

British journal of pharmacology 20010801

Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR.

American journal of physiology. Heart and circulatory physiology 20010701

Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.

Biochemical and biophysical research communications 20010622

Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide.

Biochemical pharmacology 20010601

SCF-induced airway hyperreactivity is dependent on leukotriene production.

American journal of physiology. Lung cellular and molecular physiology 20010601

Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1.

Blood 20010601

Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells.

European journal of pharmacology 20010601

Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus.

Life sciences 20010511

Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.

Molecular pharmacology 20010501

Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells.

FEBS letters 20010420

Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes.

Biochimica et biophysica acta 20010216

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress.

Journal of neurochemistry 20010101

Comparison of the properties of human breast cancer cells: MCF-7 and MCF-7 cells selected for resistance to etoposide.

Advances in enzyme regulation 20010101

The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro.

Journal of submicroscopic cytology and pathology 20010101

Characterization of the human cysteinyl leukotriene 2 receptor.

The Journal of biological chemistry 20000929

Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals.

Toxicology 20000103

Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.

Molecular pharmacology 19991201

Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells.

FEBS letters 19990129

Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells.

Molecular pharmacology 19980601

Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.

Receptors & signal transduction 19960101

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

The Journal of biological chemistry 19941111

BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes.

European journal of pharmacology 19941103

Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.

The Journal of pharmacology and experimental therapeutics 19940601

Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.

Thorax 19931201

Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.

European journal of pharmacology 19930215

A second cysteinyl leukotriene receptor in human lung.

The Journal of pharmacology and experimental therapeutics 19921101

Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Inflammation 19920601