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Tolazamide

CAS No.:
1156-19-0
Catalog Number:
AG000G8X
Molecular Formula:
C14H21N3O3S
Molecular Weight:
311.3998
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$133
- +
10mg
≥98%
1 week
United States
$194
- +
50mg
99%
1 week
United States
$333
- +
Product Description
Catalog Number:
AG000G8X
Chemical Name:
Tolazamide
CAS Number:
1156-19-0
Molecular Formula:
C14H21N3O3S
Molecular Weight:
311.3998
MDL Number:
MFCD00083504
IUPAC Name:
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
InChI:
InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChI Key:
OUDSBRTVNLOZBN-UHFFFAOYSA-N
SMILES:
O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CCCCCC1
EC Number:
214-588-3
UNII:
9LT1BRO48Q
Properties
Complexity:
431  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
311.13g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
311.4g/mol
Monoisotopic Mass:
311.13g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
86.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  
Literature
Title Journal
Epac2: a sulfonylurea receptor? Biochemical Society transactions 20120201
The management of type 2 diabetic patients with hypoglycaemic agents. ISRN endocrinology 20120101
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones. Diabetes & metabolism journal 20110801
Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study. Diabetes care 20110601
Primary language, income and the intensification of anti-glycemic medications in managed care: the (TRIAD) study. Journal of general internal medicine 20110501
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Glucose biosensors: an overview of use in clinical practice. Sensors (Basel, Switzerland) 20100101
Accuracy of Veterans Affairs databases for diagnoses of chronic diseases. Preventing chronic disease 20091001
The second-meal phenomenon in type 2 diabetes. Diabetes care 20090701
A review of exenatide as adjunctive therapy in patients with type 2 diabetes. Drug design, development and therapy 20090101
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. PloS one 20090101
Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ (Clinical research ed.) 20090101
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. Diabetes care 20081101
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nature chemical biology 20080501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry 20050407
Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes. Kidney international 20050201
Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents. American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105
Efficacy of sulfonylureas with insulin in type 2 diabetes mellitus. The Annals of pharmacotherapy 20031101
Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicological sciences : an official journal of the Society of Toxicology 20030801
Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional study. BMC health services research 20030101
[A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus]. Yakushigaku zasshi 20030101
Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. Journal of molecular endocrinology 19990401
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science (New York, N.Y.) 19951117
Oral hypoglycemic agents in the treatment of type II diabetes. American family physician 19931101
Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. Neurology 19861101
A case of chronic liver disease due to tolazamide. Gastroenterology 19850701
Wernicke's encephalopathy induced by tolazamide. The New England journal of medicine 19830908
The effect of chlorpropamide hyponatremia on mental status in a nursing home population. The Journal of family practice 19830501
Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats. Diabetes 19830301
Tolazamide-induced cholestasis. Southern medical journal 19800801
Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonyluria. Toxicology and applied pharmacology 19790701
Properties