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Fondaparinux sodium

CAS No.:
114870-03-0
Catalog Number:
AG000FCU
Molecular Formula:
C31H43N3Na10O49S8
Molecular Weight:
1728.0815
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
97%
In Stock USA
United States
$147
- +
5mg
97%
In Stock USA
United States
$211
- +
10mg
97%
In Stock USA
United States
$303
- +
Product Description
Catalog Number:
AG000FCU
Chemical Name:
Fondaparinux sodium
CAS Number:
114870-03-0
Molecular Formula:
C31H43N3Na10O49S8
Molecular Weight:
1728.0815
MDL Number:
MFCD06794972
IUPAC Name:
decasodium;(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5R,6R)-6-[(2R,3S,4S,5R,6R)-2-carboxylato-4-hydroxy-6-[(2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-5-sulfonatooxyoxan-3-yl]oxy-5-(sulfonatoamino)-4-sulfonatooxy-2-(sulfonatooxymethyl)oxan-3-yl]oxy-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylate
InChI:
InChI=1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/q;10*+1/p-10/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1
InChI Key:
XEKSTYNIJLDDAZ-JASSWCPGSA-D
SMILES:
CO[C@H]1O[C@H](COS(=O)(=O)[O-])[C@H]([C@@H]([C@H]1NS(=O)(=O)[O-])O)O[C@@H]1O[C@@H](C(=O)[O-])[C@H]([C@@H]([C@H]1OS(=O)(=O)[O-])O)O[C@H]1O[C@H](COS(=O)(=O)[O-])[C@H]([C@@H]([C@H]1NS(=O)(=O)[O-])OS(=O)(=O)[O-])O[C@@H]1O[C@H](C(=O)[O-])[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@H](COS(=O)(=O)[O-])[C@H]([C@@H]([C@H]1NS(=O)(=O)[O-])O)O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
UNII:
X0Q6N9USOZ
Properties
Complexity:
3330  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
11  
Defined Atom Stereocenter Count:
25  
Defined Bond Stereocenter Count:
0
Exact Mass:
1726.771g/mol
Formal Charge:
0
Heavy Atom Count:
101  
Hydrogen Bond Acceptor Count:
52  
Hydrogen Bond Donor Count:
9  
Isotope Atom Count:
0
Molecular Weight:
1728.035g/mol
Monoisotopic Mass:
1726.771g/mol
Rotatable Bond Count:
20  
Topological Polar Surface Area:
901A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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The influence of fondaparinux on the diagnosis of postoperative deep vein thrombosis by soluble fibrin and D-dimer. Thrombosis research 20121101
Investigating the benefit of adding a vena cava filter to anticoagulation with fondaparinux sodium in patients with cancer and venous thromboembolism in a prospective randomized clinical trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121101
Plasma accumulation of fondaparinux 2.5 mg in patients after total hip arthroplasty. Journal of thrombosis and thrombolysis 20121101
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Inferior vena cava thrombectomy in a patient with heparin-induced thrombocytopenia via inflow occlusion technique on beating heart. Interactive cardiovascular and thoracic surgery 20121001
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Vaginal delivery in a parturient excessively anticoagulated with fondaparinux. International journal of obstetric anesthesia 20121001
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Complete mass spectral characterization of a synthetic ultralow-molecular-weight heparin using collision-induced dissociation. Analytical chemistry 20120703
Cost-effectiveness of fondaparinux in patients with acute coronary syndrome without ST-segment elevation. Arquivos brasileiros de cardiologia 20120701
Reversing anticoagulant therapy. Current drug discovery technologies 20120601
Venous thromboembolism prevention with fondaparinux 1.5 mg in renally impaired patients undergoing major orthopaedic surgery. A real-world, prospective, multicentre, cohort study. Thrombosis and haemostasis 20120601
Successful desensitization with un-fractionated heparin in a patient with heparin allergy and tolerance to fondaparinux. Asian Pacific journal of allergy and immunology 20120601
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Dose determination of fondaparinux in healthy cats. American journal of veterinary research 20120401
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Preventing venous thromboembolism in hospitalized patients with cancer: improving compliance with clinical practice guidelines. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120315
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A closer look at the nitrogen next door: 1H-15N NMR methods for glycosaminoglycan structural characterization. Journal of magnetic resonance (San Diego, Calif. : 1997) 20120301
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Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux. International journal of hematology 20120201
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Efficacy and safety of fondaparinux in patients with ST-segment elevation myocardial infarction across the age spectrum. Results from the Organization for the Assessment of Strategies for Ischemic Syndromes 6 (OASIS-6) trial. American heart journal 20101201
Development and in vivo bioavailability study of an oral fondaparinux delivery system. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101120
Differential inhibitory effect of fondaparinux on the procoagulant potential of intact monocytes and monocyte-derived microparticles. Journal of thrombosis and thrombolysis 20101101
Successful surgical management of massive pulmonary embolism during the second trimester in a parturient with heparin-induced thrombocytopenia. Interactive cardiovascular and thoracic surgery 20101101
Fondaparinux thromboprophylaxis-associated heparin-induced thrombocytopenia syndrome complicated by arterial thrombotic stroke. Thrombosis and haemostasis 20101101
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Pulmonary embolectomy in heparin-induced thrombocytopenia and thrombosis? Safety of heparin use. Interactive cardiovascular and thoracic surgery 20101101
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The HIT treatment in a cardiac surgery patient. International journal of cardiology 20101029
Does aspirin have a role in venous thromboembolism prophylaxis in total knee arthroplasty patients? The Journal of arthroplasty 20101001
Incidence and time course of asymptomatic deep vein thrombosis with fondaparinux in patients undergoing total joint arthroplasty. Thrombosis research 20101001
Successful use of fondaparinux in a patient with a mechanical heart valve replacement and a history of heparin-induced thrombocytopenia. Journal of thrombosis and thrombolysis 20101001
Layer-by-layer surface modification of lipid nanocapsules. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001
Low allergenic potential with fondaparinux: results of a prospective investigation. Mayo Clinic proceedings 20101001
The treatment of venous thromboembolism in patients with cancer. Internal and emergency medicine 20101001
[Comparison of therapeutic efficacy between fondaparinux and low molecular weight heparin for patients with acute coronary syndrome]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101001
Fondaparinux: does it cause HIT? Can it treat HIT? Expert review of hematology 20101001
Fondaparinux for the treatment of superficial-vein thrombosis in the legs. The New England journal of medicine 20100923
Superficial phlebitis and phase 3.5 trials. The New England journal of medicine 20100923
Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. JAMA 20100922
DVT prophylaxis: better living through chemistry: affirms. Orthopedics 20100907
Treatment options in heparin-induced thrombocytopenia. Current opinion in hematology 20100901
Thrombocytopenia during fondaparinux prophylaxis: HIT or something different? Internal and emergency medicine 20100801
Fondaparinux as an alternative anticoagulant therapy during pregnancy. Journal of thrombosis and haemostasis : JTH 20100801
Anticoagulation by factor Xa inhibitors. Journal of thrombosis and haemostasis : JTH 20100801
Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice. Thrombosis and haemostasis 20100801
Delayed hypersensitivity to heparin in a patient with cancer: fondaparinux may be safe but needs to be tested. Contact dermatitis 20100801
Pharmacologic therapy for non ST-segment elevation acute coronary syndromes: focus on antithrombotic therapy. Cardiovascular drugs and therapy 20100801
Acute pulmonary embolism. The New England journal of medicine 20100715
Venous thromboembolism and cancer: a systematic review. Journal of thrombosis and thrombolysis 20100701
Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100701
The complex clinical picture of side effects to anticoagulation. The Medical clinics of North America 20100701
[Fondaparinux and lepirudin as therapeutic alternatives in a disseminated eczematous skin reaction to low-molecular-weight heparin]. Actas dermo-sifiliograficas 20100701
[A new deal with new anticoagulants?]. Journal des maladies vasculaires 20100601
Deep vein thrombosis: how long will it remain? Journal of anesthesia 20100601
Old versus new anticoagulants: focus on pharmacology. Recent patents on cardiovascular drug discovery 20100601
Adverse drug events associated with disorders of coagulation. Critical care medicine 20100601
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Severe bleeding secondary to misuse of fondaparinux: a case report. Journal of thrombosis and thrombolysis 20100501
Development and evaluation of a fluorescence microplate assay for quantification of heparins and other sulfated carbohydrates. Journal of pharmaceutical and biomedical analysis 20100501
Deep vein and intracardiac thrombosis during the post-partum period in Behçet's disease. International journal of hematology 20100501
[Fondaparinux in the treatment of acute coronary syndromes]. Zhonghua xin xue guan bing za zhi 20100501
Early discharge of patients with venous thromboembolism: implications regarding therapy. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100401
Paroxysmal nocturnal hemoglobinuria following alemtuzumab immunosuppressive therapy for myelodysplastic syndrome and complicated by recurrent life-threatening thrombosis despite anticoagulation: successful intervention with eculizumab and fondaparinux. Leukemia research 20100401
Inhibitors of slit protein interactions with the heparan sulphate proteoglycan glypican-1: potential agents for the treatment of spinal cord injury. Clinical and experimental pharmacology & physiology 20100401
Fondaparinux or enoxaparin: a comparative study of postoperative bleeding in coronary artery bypass grafting surgery. Scandinavian cardiovascular journal : SCJ 20100401
Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor. Thrombosis and haemostasis 20100401
Update on fondaparinux: role in management of thromboembolic and acute coronary events. Cardiovascular & hematological agents in medicinal chemistry 20100401
Fondaparinux in major orthopedic surgical patients. Internal and emergency medicine 20100401
Neuraxial anesthesia in obstetric patients receiving anticoagulant and antithrombotic drugs. International journal of obstetric anesthesia 20100401
Recombinant factor VIIa to manage major bleeding from newer parenteral anticoagulants. The Annals of pharmacotherapy 20100401
VTE prophylaxis for the medical patient: where do we stand? - a focus on cancer patients. Thrombosis research 20100401
Retrospective evaluation of venous thromboembolism prophylaxis in the adult cancer population. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20100301
Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. The Journal of thoracic and cardiovascular surgery 20100301
Anti-PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization. Journal of thrombosis and haemostasis : JTH 20100301
Extended prophylaxis of venous thromboembolism with fondaparinux in patients undergoing major orthopaedic surgery in Italy: a cost-effectiveness analysis. Internal and emergency medicine 20100201
Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial. Journal of thrombosis and haemostasis : JTH 20100201
Routine use of fondaparinux in acute coronary syndromes: a 2-year multicenter experience. American heart journal 20100201
Anticoagulant therapy for percutaneous coronary intervention. Circulation. Cardiovascular interventions 20100201
Factor Xa inhibitors in acute coronary syndromes and venous thromboembolism. Current vascular pharmacology 20100101
Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia. International journal of obstetric anesthesia 20100101
Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening. Analytical biochemistry 20100101
Relationship between baseline haemoglobin and major bleeding complications in acute coronary syndromes. European heart journal 20100101
Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100101
A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions. Acta chirurgica Belgica 20100101
Heparin-induced thrombocytopenia in a patient treated with fondaparinux. Clinical advances in hematology & oncology : H&O 20100101
Heparin-induced thrombocytopenia associated with fondaparinux. Clinical advances in hematology & oncology : H&O 20100101
Fondaparinux and acute coronary syndromes: update on the OASIS 5-6 studies. Vascular health and risk management 20100101
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[Update on current care guidelines: venous thrombosis and pulmonary embolism]. Duodecim; laaketieteellinen aikakauskirja 20100101
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Managing bleeding complications in patients treated with the old and the new anticoagulants. Current pharmaceutical design 20100101
The 'chest pain kit' study: A 'pill in the pocket' concept to improve the pre-hospital therapy of acute coronary syndrome. Cardiology journal 20100101
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Therapeutic use of heparin beyond anticoagulation. Current drug discovery technologies 20091201
Thromboprophylaxis and heparin-induced thrombocytopenia. British journal of hospital medicine (London, England : 2005) 20091201
The case for venous thromboembolism prophylaxis in Africa. East African medical journal 20091201
Major bleeding, mortality, and efficacy of fondaparinux in venous thromboembolism prevention trials. Circulation 20091117
Coagulation factor Xa activates thrombin in ischemic neural tissue. Journal of neurochemistry 20091101
Favorable coagulation profile with fondaparinux after hip surgery in elderly patients. International journal of hematology 20091101
Fondaparinux for prevention of venous thromboembolism in high-risk trauma patients: a pilot study. Journal of the American College of Surgeons 20091101
From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile. Thrombosis and haemostasis 20091101
Development of idraparinux and idrabiotaparinux for anticoagulant therapy. Thrombosis and haemostasis 20091101
Binding between heparin and the integrin VLA-4. Thrombosis and haemostasis 20091101
Heptest-STAT, a new assay for monitoring of low-molecular-weight heparins, is not influenced by pregnancy-related changes of blood plasma. Thrombosis and haemostasis 20091101
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[Pregnancy and venous thromboembolism. North-American and European guidelines. American College of Chest Physicians]. Journal des maladies vasculaires 20091101
Safety and efficacy of fondaparinux as an adjunctive treatment to thrombolysis in patients with high and intermediate risk pulmonary embolism. Journal of thrombosis and thrombolysis 20091001
A retrospective analysis of fondaparinux versus enoxaparin treatment in women with infertility or pregnancy loss. American journal of reproductive immunology (New York, N.Y. : 1989) 20091001
Fondaparinux and the management of heparin-induced thrombocytopenia: the journey continues. The Annals of pharmacotherapy 20091001
Automated assay for fondaparinux (Arixtra) on the Dade Behring BCS XP. American journal of clinical pathology 20091001
A new era for anticoagulants. European journal of internal medicine 20091001
Heparin induced thrombocytopenia and re-thrombosis associated with warfarin and fondaparinux in a child. Pediatric blood & cancer 20090901
Perioperative anticoagulant management. The Medical clinics of North America 20090901
The benefit of sample pretreatment and use of MS(10) on the Orbitrap for the analysis of pentasaccharides. Rapid communications in mass spectrometry : RCM 20090901
The reduced anticoagulant effect of fondaparinux at low antithrombin levels. Anesthesia and analgesia 20090901
Prospective randomized controlled trial on the effect of fondaparinux sodium for prevention of venous thromboembolism after hip fracture surgery. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20090901
Dabigatran etexilate for the prevention of venous thromboembolism in patients undergoing elective hip and knee surgery: a single technology appraisal. Health technology assessment (Winchester, England) 20090901
Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial. Journal of the American College of Cardiology 20090728
New antithrombotic agents in acute coronary syndromes. Current opinion in cardiology 20090701
Fondaparinux and epidural anaesthesia. International journal of obstetric anesthesia 20090701
Epidural labor analgesia in a patient receiving fondaparinux. International journal of obstetric anesthesia 20090701
Expert consensus on treatment strategies in non- ST-segment elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention--an evidence-based review of clinical trial results and treatment guidelines from an emergency medicine perspective: report on a roundtable discussion. The American journal of emergency medicine 20090701
Prescription of fondaparinux in hospitalised patients. Thrombosis and haemostasis 20090601
Hospitals with and without percutaneous coronary intervention capability: considerations for treating acute coronary syndromes. The American journal of emergency medicine 20090601
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Economic and clinical evaluation of fondaparinux vs. enoxaparin for thromboprophylaxis following general surgery. Current medical research and opinion 20090501
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Treatment of venous thromboembolism in patients with cancer: subgroup analysis of the Matisse clinical trials. Thrombosis and haemostasis 20090401
Improving clinical outcomes by reducing bleeding in patients with non-ST-elevation acute coronary syndromes. European heart journal 20090301
Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC. Thrombosis research 20090301
The pain and the gain of treating patients with acute coronary syndromes-can the two be separated? American heart journal 20090301
Fondaparinux compared to enoxaparin in patients with acute coronary syndromes without ST-segment elevation: outcomes and treatment effect across different levels of risk. American heart journal 20090301
Guideline update. VTE disease: which agents, and when. The Journal of family practice 20090301
Fondaparinux in the treatment of acute coronary syndromes: evidence from OASIS 5 and 6. Expert review of cardiovascular therapy 20090301
Pharmacokinetic and clinical data supporting the use of fondaparinux 1.5 mg once daily in the prevention of venous thromboembolism in renally impaired patients. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090301
[Advances in antithrombotic treatment--antithrombotics with anti-Xa effect]. Vnitrni lekarstvi 20090301
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Do we really need an interval between administering fondaparinux and removing a lumbar plexus catheter? Anesthesia and analgesia 20090201
Heparin-induced thrombocytopenia: what clinicians need to know. Thrombosis and haemostasis 20090201
Laboratory monitoring of anticoagulation: where do we stand? Seminars in thrombosis and hemostasis 20090201
Avoiding and managing bleeding complications in patients with non-ST-segment elevation acute coronary syndromes. Angiology 20090101
Epidural labor analgesia in a patient receiving fondaparinux. International journal of obstetric anesthesia 20090101
[Prevention of deep vein thrombosis in surgical and non-surgical patients]. Hamostaseologie 20090101
Fondaparinux: a different weapon in the war on clot: update for the clinical nurse specialist. Clinical nurse specialist CNS 20090101
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Tissue factor and factor v involvement in rat peritoneal fibrosis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20090101
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Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: successful treatment with repeated TIPS and interferon alpha. Journal of cancer research and therapeutics 20090101
Delayed-onset heparin-induced thrombocytopenia type-2 during fondiparinux (Arixtra) therapy. Proceedings of the Western Pharmacology Society 20090101
Bias in AJHP supplements. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081215
Heparin-induced thrombocytopenia--therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes. Journal of thrombosis and haemostasis : JTH 20081201
Postinjury thromboprophylaxis. Current opinion in critical care 20081201
[Pharmacology of heparins and direct anticoagulants]. Hamostaseologie 20081201
[Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. Kardiologia polska 20081201
[Perioperative venous thromboembolism prophylaxis: short review and recommendations]. Annales francaises d'anesthesie et de reanimation 20081201
Antithrombotic therapy with fondaparinux in relation to interventional management strategy in patients with ST- and non-ST-segment elevation acute coronary syndromes: an individual patient-level combined analysis of the Fifth and Sixth Organization to Assess Strategies in Ischemic Syndromes (OASIS 5 and 6) randomized trials. Circulation 20081111
Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxis. American journal of hematology 20081101
The use of graduated compression stockings in association with fondaparinux in surgery of the hip: a multicentre, multinational, randomised, open-label, parallel-group comparative study. The Journal of bone and joint surgery. British volume 20081101
The synthetic pentasaccharide fondaparinux prevents coronary microvascular injury and myocardial dysfunction in the ischemic heart. Thrombosis and haemostasis 20081101
[Venous thromboembolism and immobilization for medical reason]. Medicina clinica 20081101
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Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia. British journal of haematology 20081001
Recombinant activated factor VII for acute subdural haematoma in an elderly patient taking fondaparinux. British journal of anaesthesia 20081001
Prevention of venous thromboembolism in hospitalized medical patients. The Mount Sinai journal of medicine, New York 20081001
New anticoagulants. Current opinion in hematology 20080901
Prothrombinase-induced clotting time assay for determination of the anticoagulant effects of unfractionated and low-molecular-weight heparins, fondaparinux, and thrombin inhibitors. American journal of clinical pathology 20080901
Venous thromboembolism clinically detected after hip fracture surgery with prophylaxis in a clinical practice setting. American journal of orthopedics (Belle Mead, N.J.) 20080901
Fondaparinux prevents venous thromboembolism after joint replacement surgery in Japanese patients. International orthopaedics 20080801
Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty. Clinical orthopaedics and related research 20080801
Thrombin generation assays are superior to traditional tests in assessing anticoagulation reversal in vitro. Thrombosis and haemostasis 20080801
Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis. World journal of gastroenterology 20080728
2007 Guideline update for unstable angina/non-ST-segment elevation myocardial infarction: focus on antiplatelet and anticoagulant therapies. The Annals of pharmacotherapy 20080701
Which heparin and how much? Current cardiology reports 20080701
Fondaparinux-related thrombocytopenia in a patient with former HIT. Response to Rota et al. (Thromb Haemost 2008; 99: 779-781). Thrombosis and haemostasis 20080701
VTE prevention in major orthopedic surgery. Cleveland Clinic journal of medicine 20080701
VTE prevention in major orthopedic surgery. Cleveland Clinic journal of medicine 20080701
Can heparin-induced thrombocytopenia be associated with fondaparinux use? A rebuttal. Journal of thrombosis and haemostasis : JTH 20080701
Electrochemical recognition of synthetic heparin mimetic at liquid/liquid microinterfaces. Journal of the American Chemical Society 20080611
In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus. Coronary artery disease 20080601
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
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The use of fondaparinux for the treatment of venous thromboembolism in a patient with heparin-induced thombocytopenia and thrombosis caused by heparin flushes. Therapeutics and clinical risk management 20080601
Successful use of fondaparinux as an alternative anticoagulant in a 2-month-old infant. Pediatric blood & cancer 20080501
Heparins, low-molecular-weight heparins, and pentasaccharides: use in the older patient. Cardiology clinics 20080501
Prevention of venous thromboembolism in the geriatric patient. Cardiology clinics 20080501
Anticoagulant treatment of deep vein thrombosis and pulmonary embolism. Cardiology clinics 20080501
The effect of anticoagulant pharmacotherapy on fracture healing. Expert opinion on pharmacotherapy 20080501
Initial management of deep venous thrombosis in the outpatient setting. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080501
Heparin-induced thrombocytopenia: a review of current pharmacologic treatment. Connecticut medicine 20080501
Detection of surface bound complement at increasing serum anticoagulant concentrations. Colloids and surfaces. B, Biointerfaces 20080401
Fondaparinux in patients with impaired renal function: the right choice? Annals of internal medicine 20080401
Post-thrombotic syndrome in children: a single center experience. Journal of pediatric hematology/oncology 20080401
Fondaparinux-related thrombocytopenia in a previous low-molecular-weight heparin (LMWH)-induced heparin-induced thrombocytopenia (HIT). Thrombosis and haemostasis 20080401
Fondaparinux for the prevention or treatment of venous thromboembolism related to lower limb trauma: evidence today. Current vascular pharmacology 20080401
Use of fondaparinux as an anticoagulant during hemodialysis: a preliminary study. International journal of clinical pharmacology and therapeutics 20080401
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20080401
Prevention of venous thromboembolism in the orthopedic surgery patient. Cleveland Clinic journal of medicine 20080401
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Prevention of venous thromboembolism in the cancer surgery patient. Cleveland Clinic journal of medicine 20080401
New anticoagulant strategies in ST elevation myocardial infarction: trials and clinical implications. Vascular health and risk management 20080401
[Fondaparinux: the present and the future]. Pathologie-biologie 20080301
Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty. Clinical orthopaedics and related research 20080301
Tolerance of fondaparinux in patients with generalized contact dermatitis to heparin. Journal of the European Academy of Dermatology and Venereology : JEADV 20080301
Standardizing the management of heparin-induced thrombocytopenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080215
Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment. European heart journal 20080201
The role of fondaparinux as an adjunct to thrombolytic therapy in acute myocardial infarction: a subgroup analysis of the OASIS-6 trial. European heart journal 20080201
[New anticoagulants]. Hamostaseologie 20080201
Recent developments in acute coronary syndromes. Clinical medicine (London, England) 20080201
Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer. The Cochrane database of systematic reviews 20080123
Fondaparinux: use in thromboprophylaxis of acute medical patients. Drugs & aging 20080101
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT)--bridging the River Coumarin. Thrombosis and haemostasis 20080101
Fondaparinux for the treatment of patients with acute heparin-induced thrombocytopenia. Thrombosis and haemostasis 20080101
Heparin-induced thrombocytopenia: a stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings. Thrombosis research 20080101
Citrate anticoagulation protocol for slow extended hemodialysis with the Genius dialysis system in acute renal failure. The International journal of artificial organs 20080101
Primary prophylaxis of venous thromboembolism in surgical patients. Vascular and endovascular surgery 20080101
The in vitro anticoagulant effects of danaparoid, fondaparinux, and lepirudin in children compared to adults. Thrombosis research 20080101
Fondaparinux sodium: a review of its use in the management of acute coronary syndromes. American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101
Factor Xa inactivation in acute coronary syndrome. Current pharmaceutical design 20080101
Monitoring direct FXa-inhibitors and fondaparinux by Prothrombinase-induced Clotting Time (PiCT): relation to FXa-activity and influence of assay modifications. Thrombosis research 20080101
Parenteral anticoagulation may prolong the survival of patients with limited small cell lung cancer: a Cochrane systematic review. Journal of experimental & clinical cancer research : CR 20080101
[Guidelines for prevention of venous thromboembolism in Austria]. Wiener klinische Wochenschrift 20080101
[Novel anticoagulant fondaparinux in the treatment of acute coronary syndrome]. Kardiologiia 20080101
Spotlight on fondaparinux sodium in acute coronary syndromes. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20080101
New anticoagulants in children. Hematology. American Society of Hematology. Education Program 20080101
[Fondaparinux and invasive treatment of non-ST elevation acute coronary syndrome]. Kardiologiia 20080101
Heparin-induced thrombocytopenia and phlegmasia cerulea dolens of the upper limb successfully treated with fondaparinux. Acta haematologica 20080101
[Venous thromboembolism prophylaxis in major orthopaedic surgery: A multicenter, prospective, observational study]. Acta orthopaedica et traumatologica turcica 20080101
Cost-effectiveness of extended prophylaxis with fondaparinux compared with low molecular weight heparin against venous thromboembolism in patients undergoing hip fracture surgery. The European journal of health economics : HEPAC : health economics in prevention and care 20071201
Inhibition of thrombin generation in recalcified plasma. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201
The safety and efficacy of extended thromboprophylaxis with fondaparinux after major orthopedic surgery of the lower limb with or without a neuraxial or deep peripheral nerve catheter: the EXPERT Study. Anesthesia and analgesia 20071201
Use of the pentasaccharide fondaparinux as an anticoagulant during haemodialysis. Thrombosis and haemostasis 20071201
Once-daily fondaparinux monotherapy without warfarin for long-term treatment of venous thromboembolism. Thrombosis and haemostasis 20071201
Fondaparinux as an alternative therapy in heparin-induced delayed-type hypersensitivity skin lesions. Thrombosis and haemostasis 20071201
Delayed hypersensitivity to low-molecular-weight heparin (LMWH) in pregnancy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20071201
Comparison of cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgery. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071115
Efficacy and safety of fondaparinux in patients with acute coronary syndromes. Expert review of cardiovascular therapy 20071101
Nonbleeding complications of unfractionated and low-molecular weight heparins. Clinical advances in hematology & oncology : H&O 20071101
Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. Journal of the American College of Cardiology 20071030
Monitoring fondaparinux with the Sonoclot. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071001
The pharmacoeconomics of deep vein thrombosis treatment. The American journal of medicine 20071001
[Heparin-induced thrombocytopenia]. Revista espanola de cardiologia 20071001
[Optimizing antithrombotic therapy in non-ST-elevation acute coronary syndrome]. Revista espanola de cardiologia 20071001
The Editor's Roundtable: arterial thrombosis and acute coronary syndromes. The American journal of cardiology 20070915
Influence of renal function on the efficacy and safety of fondaparinux relative to enoxaparin in non ST-segment elevation acute coronary syndromes. Annals of internal medicine 20070904
The prophylaxis of venous thrombosis in patients with cancer undergoing major abdominal surgery: emerging options. Journal of surgical oncology 20070901
Fondaparinux combined with intermittent pneumatic compression vs. intermittent pneumatic compression alone for prevention of venous thromboembolism after abdominal surgery: a randomized, double-blind comparison. Journal of thrombosis and haemostasis : JTH 20070901
Extended travel after hip arthroplasty surgery. Is it safe? The Journal of arthroplasty 20070901
Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia. Current cardiology reports 20070901
[Heparin-induced thrombocytopenia: a brief update in an Italian perspective]. Recenti progressi in medicina 20070901
Treatment of thrombosis with fondaparinux (Arixtra) in a patient with end-stage renal disease receiving hemodialysis therapy. Journal of pediatric hematology/oncology 20070801
Beyond unfractionated heparin and warfarin: current and future advances. Circulation 20070731
Prophylaxis for thromboembolism in hospitalized medical patients. The New England journal of medicine 20070719
New anticoagulant options for ST-elevation myocardial infarction and unstable angina pectoris/non-ST-elevation myocardial infarction. Current cardiology reports 20070701
Enzymatic synthesis of glycosaminoglycan heparin. Seminars in thrombosis and hemostasis 20070701
Determination of antithrombin-dependent factor Xa inhibitors by prothrombin-induced clotting time. Seminars in thrombosis and hemostasis 20070701
The use of graduated compression stockings in association with fondaparinux in surgery of the hip. A multicentre, multinational, randomised, open-label, parallel-group comparative study. The Journal of bone and joint surgery. British volume 20070701
Heparin-induced thrombocytopenia associated with fondaparinux. The New England journal of medicine 20070621
Minimizing costs for treating deep vein thrombosis: the role for fondaparinux. Journal of thrombosis and thrombolysis 20070601
Effect of obesity on outcomes after fondaparinux, enoxaparin, or heparin treatment for acute venous thromboembolism in the Matisse trials. Journal of thrombosis and haemostasis : JTH 20070601
Assessing, preventing, and treating venous thromboembolism: evidence-based approaches. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070601
Fondaparinux as a treatment option for heparin-induced thrombocytopenia. Pharmacotherapy 20070601
[Standards and perspectives for thromboembolism prophylaxis]. Der Orthopade 20070601
Bioengineering novel in vitro metabolic pathways using synthetic biology. Current opinion in microbiology 20070601
[Fondaparinux in the treatment of pulmonary thromboembolism: MATISSE study]. Revista clinica espanola 20070601
Management of acute coronary syndromes with fondaparinux. Vascular health and risk management 20070601
Prevention and treatment of venous thromboembolism in the elderly patient. Clinical interventions in aging 20070601
[Initial treatment of venous thromboembolic events]. La Revue du praticien 20070415
Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients. The New England journal of medicine 20070405
Fondaparinux: pharmacology and clinical experience in cardiovascular medicine. Mini reviews in medicinal chemistry 20070401
Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a. International journal of clinical pharmacology and therapeutics 20070401
High affinity interaction between a synthetic, highly negatively charged pentasaccharide and alpha- or beta-antithrombin is predominantly due to nonionic interactions. Biochemistry 20070320
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301
Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939)--an oral, direct factor Xa inhibitor. Thrombosis and haemostasis 20070301
Fondaparinux is an effective alternative anticoagulant in pregnant women with high risk of venous thromboembolism and intolerance to low-molecular-weight heparins and heparinoids. Thrombosis and haemostasis 20070301
Perioperative bridging with fondaparinux in a woman with antithrombin deficiency. Thrombosis and haemostasis 20070301
Low-dose fondaparinux in suspected heparin-induced thrombocytopenia in the critically ill. The Netherlands journal of medicine 20070301
[Fondaparinux--evolution or revolution in anticoagulant care?]. Polskie Archiwum Medycyny Wewnetrznej 20070301
New anticoagulants: from bench to bedside. Hamostaseologie 20070201
American Society of Hematology--48th Annual Meeting and Exposition. The Factor Xa target, and disorders of platelet number and function. 9-12 December 2006 Orlando, FL, USA. IDrugs : the investigational drugs journal 20070201
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. American journal of respiratory and critical care medicine 20070115
Treatment of a woman with lupus and thromboembolism and cutaneous intolerance to heparins using fondaparinux during pregnancy. Thrombosis research 20070101
Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro. Thrombosis research 20070101
Clot structure modification by fondaparinux and consequence on fibrinolysis: a new mechanism of antithrombotic activity. Thrombosis and haemostasis 20070101
Fondaparinux in the management of recurrent venous thromboembolic events in a patient with active lung cancer. Thrombosis research 20070101
Venous thromboembolism after orthopedic surgery: implications of the choice for prophylaxis. Thrombosis research 20070101
[Prevention of venous thromboembolism in orthopedic surgery and traumatology]. Recenti progressi in medicina 20070101
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Delayed-type hypersensitivity to the ultra-low-molecular-weight heparin fondaparinux. Contact dermatitis 20040901
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Pentasaccharides. The new anticoagulants. Saudi medical journal 20040801
New trends in anticoagulant therapy. The Israel Medical Association journal : IMAJ 20040801
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A cost analysis of fondaparinux versus enoxaparin in total knee arthroplasty. American journal of therapeutics 20040101
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Recombinant factor VIIa reverses the in vitro and ex vivo anticoagulant and profibrinolytic effects of fondaparinux. Journal of thrombosis and haemostasis : JTH 20031101
Successful use of Arixtra in a patient with paroxysmal nocturnal hemoglobinuria, Budd-Chiari syndrome and heparin-induced thrombocytopenia. Journal of thrombosis and haemostasis : JTH 20031101
Thrombosis and Hemostasis Issues in Cancer - Second International Conference. 19-21 September, 2003, Bergamo, Italy. IDrugs : the investigational drugs journal 20031101
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