Phenol, 4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
| Title | Journal |
|---|---|
| Pharmacogenetics of anti-estrogen treatment of breast cancer. | Cancer treatment reviews 20120801 |
| Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. | Therapeutic drug monitoring 20120801 |
| Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. | Breast cancer research and treatment 20120701 |
| Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score. | Breast cancer research and treatment 20120601 |
| Importance of highly selective LC-MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen. | Breast cancer research and treatment 20120601 |
| Deriving rules and assertions from pharmacogenomics knowledge resources in support of patient drug metabolism efficacy predictions. | Journal of the American Medical Informatics Association : JAMIA 20120101 |
| Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis. | Journal of cardiovascular pharmacology 20111201 |
| Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: effect on active metabolite isomers and the antiestrogenic activity score. | Clinical pharmacology and therapeutics 20111001 |
| Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. | European journal of medicinal chemistry 20110901 |
| Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820 |
| Personalized tamoxifen: what is the best way forward? | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820 |
| Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110820 |
| Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin. | Biochimie 20110701 |
| P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration. | The Journal of pharmacology and experimental therapeutics 20110601 |
| Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes. | Clinical pharmacology and therapeutics 20110501 |
| Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients. | British journal of clinical pharmacology 20110501 |
| Development of a methodology to quantify tamoxifen and endoxifen in breast cancer patients by micellar liquid chromatography and validation according to the ICH guidelines. | Talanta 20110415 |
| Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1). | Drug metabolism and disposition: the biological fate of chemicals 20110301 |
| Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen. | Breast cancer research and treatment 20110101 |
| Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. | Breast cancer research : BCR 20110101 |
| A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer. | BMC systems biology 20110101 |
| Endoxifen, a new cornerstone of breast cancer therapy: demonstration of safety, tolerability, and systemic bioavailability in healthy human subjects. | Clinical pharmacology and therapeutics 20101201 |
| Update on CYP2D6 and its impact on tamoxifen therapy. | Clinical advances in hematology & oncology : H&O 20100801 |
| Orally administered endoxifen is a new therapeutic agent for breast cancer. | Breast cancer research and treatment 20100701 |
| Coprescription of tamoxifen and medications that inhibit CYP2D6. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100601 |
| Selective serotonin reuptake inhibitors and adjuvant tamoxifen therapy: risk of breast cancer recurrence and mortality. | Future oncology (London, England) 20100601 |
| A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). | Bioorganic & medicinal chemistry letters 20100515 |
| Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen. | Journal of medicinal chemistry 20100422 |
| Endoxifen is a new potent inhibitor of PKC: a potential therapeutic agent for bipolar disorder. | Bioorganic & medicinal chemistry letters 20100415 |
| [CYP2D6 polymorphisms and tamoxifen: therapeutic perspectives in the management of hormonodependent breast cancer patients]. | Bulletin du cancer 20100301 |
| CYP2D6 testing in breast cancer: ready for prime time? | Oncology (Williston Park, N.Y.) 20091201 |
| Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. | Oncology (Williston Park, N.Y.) 20091201 |
| CYP2D6 testing for breast cancer patients: is there more to the story? | Oncology (Williston Park, N.Y.) 20091201 |
| The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users. | Breast cancer research and treatment 20091101 |
| Tamoxifen, antidepressants, and CYP2D6: the conundrum continues. | Journal of the National Cancer Institute 20091021 |
| Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810 |
| Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed. | Basic & clinical pharmacology & toxicology 20090501 |
| The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. | Cancer research 20090301 |
| Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. | Cancer research 20090301 |
| Drug interactions and pharmacogenomics in the treatment of breast cancer and depression. | The American journal of psychiatry 20081001 |
| Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. | Annals of oncology : official journal of the European Society for Medical Oncology 20080101 |
| TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells. | Breast cancer research and treatment 20080101 |
| Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
| Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. | Drug metabolism and disposition: the biological fate of chemicals 20071001 |
| Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. | Cancer chemotherapy and pharmacology 20050501 |
| Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. | Breast cancer research and treatment 20040501 |