Home Other Building Blocks Edrophonium chloride

Edrophonium chloride

CAS No.:
116-38-1
Catalog Number:
AG000BCS
Molecular Formula:
C10H16ClNO
Molecular Weight:
201.6931
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
In Stock USA
United States
$57
- +
25mg
98%
In Stock USA
United States
$94
- +
250mg
95%
In Stock USA
United States
$119
- +
1g
95%
In Stock USA
United States
$294
- +
5g
95%
In Stock USA
United States
$1238
- +
25g
95%
In Stock USA
United States
$3725
- +
Product Description
Catalog Number:
AG000BCS
Chemical Name:
Edrophonium chloride
CAS Number:
116-38-1
Molecular Formula:
C10H16ClNO
Molecular Weight:
201.6931
MDL Number:
MFCD00055064
IUPAC Name:
ethyl-(3-hydroxyphenyl)-dimethylazanium;chloride
InChI:
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChI Key:
BXKDSDJJOVIHMX-UHFFFAOYSA-N
SMILES:
CC[N+](c1cccc(c1)O)(C)C.[Cl-]
EC Number:
204-138-4
UNII:
QO611KSM5P
NSC Number:
759577
Properties
Complexity:
145  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
201.092g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
201.694g/mol
Monoisotopic Mass:
201.092g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
20.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence. Chemico-biological interactions 20161125
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal 20121115
Congenital myasthenic syndromes: current diagnostic and therapeutic approaches. Neuropediatrics 20120801
Myasthenia gravis can cause camptocormia. Journal of neurology, neurosurgery, and psychiatry 20120401
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Discordant thymectomy in identical twins concordant for myasthenia gravis. Annals of internal medicine 20111004
Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes. Journal of neurochemistry 20110601
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorganic & medicinal chemistry letters 20110415
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment. European journal of medicinal chemistry 20110201
Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog. Journal of the American Animal Hospital Association 20110101
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. ChemMedChem 20100903
Rapid and label-free screening of enzyme inhibitors using segmented flow electrospray ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 20100701
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011. Anesthesiology 20100701
Myasthenia gravis in an adolescent patient presenting to the pediatric emergency department. Pediatric emergency care 20100501
[Neuromuscular disease--myasthenia gravis]. MMW Fortschritte der Medizin 20100114
Pseudo-internuclear ophthalmoplegia as a sign of overlapping myasthenia gravis in a patient with 'intractable' hypothyroidism. Internal medicine (Tokyo, Japan) 20100101
A case of diplopia and arm weakness. BMJ (Clinical research ed.) 20091125
Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis. Gut 20090801
Racial differences in myasthenia gravis in Alabama. Muscle & nerve 20090301
Clinical implications of new neuromuscular concepts and agents: so long, neostigmine! So long, sux! Journal of critical care 20090301
Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. Movement disorders : official journal of the Movement Disorder Society 20080915
Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine. Gastroenterology 20080901
Evaluation and diagnosis of noncardiac chest pain. Disease-a-month : DM 20080901
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Bioorganic & medicinal chemistry 20080801
[Surprising etiology of chronic deglutition disorder. Diagnosis at a glance in dysphagia]. MMW Fortschritte der Medizin 20080605
Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep. Veterinary anaesthesia and analgesia 20080501
Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis. Muscle & nerve 20080301
Cholinergic stimulation induces asynchrony between the circular and longitudinal muscle contraction during esophageal peristalsis. American journal of physiology. Gastrointestinal and liver physiology 20080301
Fiberoptic endoscopic evaluation of swallowing with simultaneous Tensilon application in diagnosis and therapy of myasthenia gravis. Journal of neurology 20080201
Myasthenia gravis-like syndrome in a Hereford heifer. Journal of veterinary internal medicine 20080101
Relevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux disease. Alimentary pharmacology & therapeutics 20071115
[Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis]. Rinsho shinkeigaku = Clinical neurology 20071001
A case report of myasthenia gravis localized to the larynx. Auris, nasus, larynx 20070901
Diverse inhibitory actions of quaternary ammonium cholinesterase inhibitors on Torpedo nicotinic ACh receptors transplanted to Xenopus oocytes. British journal of pharmacology 20070801
Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine. Anesthesia and analgesia 20070301
Is there still a role for edrophonium in diagnosing ocular myasthenia. European journal of neurology 20070301
[Thoracic pain caused by esophageal dysfunction in patients with ischemic cardiopathy]. Medicina clinica 20070120
Dropped head sign as the only symptom of myasthenia gravis. Internal medicine (Tokyo, Japan) 20070101
Pseudomyasthenia in a patient with pontine glioma. Clinical neurology and neurosurgery 20061201
LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002
Edrophonium provocative testing for the evaluation of upper gastrointestinal hypersensitivity in patients with nonulcer dyspepsia. Digestive diseases and sciences 20060801
A systematic review of diagnostic studies in myasthenia gravis. Neuromuscular disorders : NMD 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101
Is pancreatic polypeptide response to food ingestion a reliable index of vagal function in type 1 diabetes? Scandinavian journal of clinical and laboratory investigation 20060101
Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord? Journal of neurophysiology 20051201
Bread-and-butter in diagnosis of myasthenia gravis. Archives of neurology 20051201
Nonresponsiveness to anticholinesterase agents in patients with MuSK-antibody-positive MG. Neurology 20051108
Advances in the diagnosis of neuromuscular junction disorders. American journal of physical medicine & rehabilitation 20050801
Clinical utility of videofluorography with concomitant Tensilon administration in the diagnosis of bulbar myasthenia gravis. Digestive diseases and sciences 20050501
Edrophonium-induced right ventricular outflow tract tachycardia. Pacing and clinical electrophysiology : PACE 20050101
[Role of esophageal provocative tests in the investigation of patients with chest pain of undetermined origin]. Arquivos de gastroenterologia 20050101
Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs. Journal of veterinary internal medicine 20050101
Sensory testing of the esophagus. Journal of clinical gastroenterology 20040901
'Dropped head sign' in myasthenia gravis. Neuromuscular disorders : NMD 20040901
Does acetylcholinesterase inhibition affect catecholamine secretion by adrenomedullary cells? The Israel Medical Association journal : IMAJ 20040701
Nitric oxide and cardiac muscarinic control in humans. Hypertension (Dallas, Tex. : 1979) 20040501
Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome. Neurology 20040413
Response of thymectomy: clinical and pathological characteristics among seronegative and seropositive myasthenia gravis patients. Acta neurologica Scandinavica 20040301
Myasthenia gravis in childhood. Binocular vision & strabismus quarterly 20040101
Prevalence of esophageal disorders in patients with recurrent chest pain. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101
[Biochemical characteristics of cholinesterase from taenia Hymenolepis diminuta]. Wiadomosci parazytologiczne 20040101
Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain. Biochemistry 20031230
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101
Interactions of edrophonium with neostigmine in the rat trachea. Anesthesia and analgesia 20031001
Cage amines as the stopper inhibitors of cholinesterases. Bioorganic & medicinal chemistry letters 20030901
Positive tensilon test and intracranial tumor: a case report. European journal of ophthalmology 20030701
Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase. Bioorganic & medicinal chemistry letters 20030519
The edrophonium test. Seminars in neurology 20030301
Development of generalized disease at 2 years in patients with ocular myasthenia gravis. Archives of neurology 20030201
Simplified tilt table test protocol with continuous upright position during medication administration and no hydration. Pacing and clinical electrophysiology : PACE 20030101
[Premonitory depression]. Ryoikibetsu shokogun shirizu 20030101
Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta biologica Hungarica 20030101
Autosomal recessive limb girdle myasthenia in two sisters. Neurology India 20021201
A comparison of the chronotropic and dromotropic actions between adenosine triphosphate and edrophonium in patients undergoing coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 20021001
A safe and noninvasive test for vagal integrity revisited. Archives of surgery (Chicago, Ill. : 1960) 20020801
[Ocular myasthenic syndrome and systemic lupus erythematosus]. Klinische Monatsblatter fur Augenheilkunde 20020701
The effect of edrophonium on autonomic outflow. Anesthesiology 20020301
[What to do in case of acquired ptosis]. Journal francais d'ophtalmologie 20020301
Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block. Bioorganic & medicinal chemistry letters 20020121
Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans. The Journal of pharmacology and experimental therapeutics 20020101
[Myasthenia gravis]. La Revue du praticien 20020101
[Technical consideration for repetitive nerve stimulation]. Rinsho shinkeigaku = Clinical neurology 20020101
Reversal of mivacurium chloride: edrophonium of spontaneous recovery in microscopic laryngeal surgery. Acta anaesthesiologica Sinica 20011201
Asystole induced by edrophonium following beta blockade. Neurology 20010828
Edrophonium antagonism of cisatracurium-induced neuromuscular block: dose requirements in children and adults. Anaesthesia and intensive care 20010801
[Voice disorders caused by neurological diseases]. Revista de neurologia 20010701
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites. The Journal of biological chemistry 20010629
Does 'butyrylization' of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? Biochemistry 20010626
The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder? The Journal of urology 20010501
Myasthenia gravis: an elusive diagnosis in older people. Journal of the American Geriatrics Society 20010501
Interaction of edrophonium with muscarinic acetylcholine M2 and M3 receptors. Anesthesiology 20010501
Reversal of rocuronium with edrophonium during propofol versus sevoflurane anesthesia. Acta anaesthesiologica Scandinavica 20010201
A dose-response study of anticholinesterase drugs on contractile and phosphatidylinositol responses of rat trachea. Anesthesia and analgesia 20010101
Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology 19990101
Catecholamine facilitated reentrant ventricular tachycardia: uncoupling of adenosine's antiadrenergic effects. Journal of cardiovascular electrophysiology 19990101
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. Journal of medicinal chemistry 19970912
The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. Scandinavian journal of gastroenterology 19970201
Fresh frozen plasma and edrophonium in a patient with a plasma cholinesterase deficiency. Anaesthesia 19930601
Persisting chloroquine-induced myasthenia? Acta clinica Belgica 19910101
Oculogyric crisis after the Tensilon test. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 19900101
Prospective evaluation of high-dose bethanechol in investigation of esophageal chest pain. Digestive diseases and sciences 19891101
Glycopyrronium requirements for antagonism of the muscarinic side effects of edrophonium. British journal of anaesthesia 19890101
Positive response to edrophonium in death adder (Acanthophis antarcticus) envenomation. Australian and New Zealand journal of medicine 19881001
Edrophonium-hyoscine butylbromide mixture for reversal of neuromuscular blockade: heart rate changes in infants and children. Anaesthesia 19880701
Augmented anti-acetylcholine receptor response following long-term penicillamine administration. Annals of neurology 19840701
Cardiac arrest following treatment of paroxysmal atrial tachycardia with edrophonium. Anesthesiology 19790301
Ventricular asystole after edrophonium chloride administration. JAMA 19760308
Cardiac arrest during edrophonium administration. American heart journal 19710301
Recurarization--fact or fiction. Anesthesia and analgesia 19710101
Properties