Home Other Building Blocks 2-Phenylquinolin-4-ol

2-Phenylquinolin-4-ol

CAS No.:
1144-20-3
Catalog Number:
AG000B8R
Molecular Formula:
C15H11NO
Molecular Weight:
221.2539
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
In Stock USA
United States
$103
- +
500mg
In Stock USA
United States
$151
- +
1g
In Stock USA
United States
$235
- +
2.5g
In Stock USA
United States
$415
- +
5g
In Stock USA
United States
$651
- +
10g
In Stock USA
United States
$1033
- +
25g
In Stock USA
United States
$1901
- +
50g
In Stock USA
United States
$3019
- +
Product Description
Catalog Number:
AG000B8R
Chemical Name:
2-Phenylquinolin-4-ol
CAS Number:
1144-20-3
Molecular Formula:
C15H11NO
Molecular Weight:
221.2539
MDL Number:
MFCD00160565
IUPAC Name:
2-phenyl-1H-quinolin-4-one
InChI:
InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
InChI Key:
JGABMVVOXLQCKZ-UHFFFAOYSA-N
SMILES:
Oc1cc(nc2c1cccc2)c1ccccc1
NSC Number:
28866
Properties
Complexity:
328  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
221.084g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
221.259g/mol
Monoisotopic Mass:
221.084g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway. Chemico-biological interactions 20161225
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V. European journal of medicinal chemistry 20120801
Antioxidant properties of 4-quinolones and structurally related flavones. Bioorganic & medicinal chemistry 20120115
KHC-4 anti-cancer effects on human PC3 prostate cancer cell line. The American journal of Chinese medicine 20120101
Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. Journal of medicinal chemistry 20110825
Non-covalent inhibitors of rhinovirus 3C protease. Bioorganic & medicinal chemistry letters 20110115
Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. Journal of biomedical science 20110101
Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091201
Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells. Anticancer research 20090801
Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors. PloS one 20090101
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Molecular cancer therapeutics 20080201
CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression. Cancer letters 20071108
Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Biochemical pharmacology 20070630
2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells. European journal of pharmacology 20070315
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. Bioorganic & medicinal chemistry 20050715
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. Bioorganic & medicinal chemistry 20050103
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. Journal of medicinal chemistry 20011108
Properties