Home Other Building Blocks 1H-Imidazole, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

1H-Imidazole, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

CAS No.:
113775-47-6
Catalog Number:
AG0009NM
Molecular Formula:
C13H16N2
Molecular Weight:
200.2795
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Purity
Availability
Location
Price(USD)
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Product Description
Catalog Number:
AG0009NM
Chemical Name:
1H-Imidazole, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-
CAS Number:
113775-47-6
Molecular Formula:
C13H16N2
Molecular Weight:
200.2795
MDL Number:
MFCD00880557
IUPAC Name:
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
InChI:
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
InChI Key:
CUHVIMMYOGQXCV-NSHDSACASA-N
SMILES:
Cc1cccc(c1C)[C@@H](c1cnc[nH]1)C
UNII:
67VB76HONO
Properties
Complexity:
205  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
200.131g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
200.285g/mol
Monoisotopic Mass:
200.131g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
28.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1  
Literature
Title Journal
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Insight into the effects of dexmedetomidine on intraoperative hemodynamics and postanesthetic recovery speed. Korean journal of anesthesiology 20120201
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Dexmedetomidine and clonidine induce long-lasting activation of the respiratory rhythm generator of neonatal mice: possible implication for critical care. Respiratory physiology & neurobiology 20120115
Inhibition by dexmedetomidine of the activation of spinal dorsal horn glias and the intracellular ERK signaling pathway induced by nerve injury. Brain research 20120103
Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting? Journal of intensive care medicine 20120101
Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption. European journal of clinical investigation 20120101
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Medetomidine, an α(2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control. Circulation journal : official journal of the Japanese Circulation Society 20120101
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Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. The Journal of pharmacy and pharmacology 20120101
Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses. Veterinary anaesthesia and analgesia 20120101
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. The journal of pain : official journal of the American Pain Society 20120101
Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study. Physiological research 20120101
Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical care research and practice 20120101
The effects of dexmedetomidine on attenuation of stress response to endotracheal intubation in patients undergoing elective off-pump coronary artery bypass grafting. Annals of cardiac anaesthesia 20120101
Chronic rejection pathology after orthotopic lung transplantation in mice: the development of a murine BOS model and its drawbacks. PloS one 20120101
Contact with domestic dogs increases pathogen exposure in endangered African wild dogs (Lycaon pictus). PloS one 20120101
Chemical immobilization of raccoons (Procyon lotor) with ketamine-medetomidine mixture and reversal with atipamezole. Journal of wildlife diseases 20120101
Dexmedetomidine: current role in anesthesia and intensive care. Revista brasileira de anestesiologia 20120101
The role of the multiple banded antigen of Ureaplasma parvum in intra-amniotic infection: major virulence factor or decoy? PloS one 20120101
Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging. PloS one 20120101
Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model. Fluids and barriers of the CNS 20120101
Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20120101
Relationship of orthopedic examination, goniometric measurements, and radiographic signs of degenerative joint disease in cats. BMC veterinary research 20120101
Prevention, recognition, and management of delirium in the intensive care unit. AACN advanced critical care 20120101
Alteration of sensory-evoked metabolic and oscillatory activities in the olfactory bulb of GLAST-deficient mice. Frontiers in neural circuits 20120101
Clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts. PloS one 20120101
eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. PloS one 20120101
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Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial. PloS one 20120101
Comparison of sedative drugs under peribulbar or topical anesthesia during phacoemulsification. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20120101
Bispectral index and their relation with consciousness of the patients who receive desflurane or sevoflurane anesthesia during wake-up test for spinal surgery for correction. Korean journal of anesthesiology 20120101
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Reduction in the incidence of shivering with perioperative dexmedetomidine: A randomized prospective study. Journal of anaesthesiology, clinical pharmacology 20120101
Anesthetic management of deep brain stimulator implantation in Meige's syndrome. Journal of anaesthesiology, clinical pharmacology 20120101
Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. PloS one 20120101
Homing and long-term engraftment of long- and short-term renewal hematopoietic stem cells. PloS one 20120101
Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production. PloS one 20120101
Transdermal delivery of scopolamine by natural submicron injectors: in-vivo study in pig. PloS one 20120101
The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs. Journal of drug delivery 20120101
Risks of using antifouling biocides in aquaculture. International journal of molecular sciences 20120101
Premedication: Is clonidine the answer? Saudi journal of anaesthesia 20120101
Retraction note. Saudi journal of anaesthesia 20120101
Changes in bispectral index values can predict post-ictal phase during awake craniotomy. Saudi journal of anaesthesia 20120101
Seizure during embolization of arteriovenous malformation. Saudi journal of anaesthesia 20120101
Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats. Experimental & translational stroke medicine 20120101
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease. PloS one 20120101
Effects of anesthetic agents on brain blood oxygenation level revealed with ultra-high field MRI. PloS one 20120101
Does vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability? Bratislavske lekarske listy 20120101
In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model. Biomedical engineering online 20120101
Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training. Frontiers in behavioral neuroscience 20120101
Cigarette smoking and the effect of dexmedetomidine and fentanyl on tracheal intubation. Revista brasileira de anestesiologia 20120101
Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats. BMC musculoskeletal disorders 20120101
Identification of a novel idiopathic epilepsy locus in Belgian Shepherd dogs. PloS one 20120101
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts. PloS one 20120101
A review of pharmacologic management and prevention strategies for delirium in the intensive care unit. Psychosomatics 20120101
A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response. Mediators of inflammation 20120101
Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. BMC neurology 20120101
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement. Frontiers in behavioral neuroscience 20120101
Sleep endoscopy in the evaluation of pediatric obstructive sleep apnea. International journal of pediatrics 20120101
Economic evaluation of dexmedetomidine relative to midazolam for sedation in the intensive care unit. The Canadian journal of hospital pharmacy 20120101
TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse. Scientific reports 20120101
Nonuniform cardiac denervation observed by 11C-meta-hydroxyephedrine PET in 6-OHDA-treated monkeys. PloS one 20120101
Early healing events around titanium implant devices with different surface microtopography: a pilot study in an in vivo rabbit model. TheScientificWorldJournal 20120101
Assessment of hereditary retinal degeneration in the English springer spaniel dog and disease relationship to an RPGRIP1 mutation. Stem cells international 20120101
Complications of three deep sedation methods for magnetic resonance imaging. Journal of anaesthesiology, clinical pharmacology 20120101
The use of intrathecal dexmedetomidine and magnesium. Journal of anaesthesiology, clinical pharmacology 20120101
Alternative approach for the anesthetic management of a patient with large pulmonary bulla presenting with an intracranial tumor for surgery. Journal of anaesthesiology, clinical pharmacology 20120101
Seasonal patterns of body temperature daily rhythms in group-living Cape ground squirrels Xerus inauris. PloS one 20120101
Development and utility of an internal threshold control (ITC) real-time PCR assay for exogenous DNA detection. PloS one 20120101
A new approach of in vivo musculoskeletal tissue engineering using the epigastric artery as central core vessel of a 3-dimensional construct. Plastic surgery international 20120101
Morphine and clonidine synergize to ameliorate low back pain in mice. Pain research and treatment 20120101
An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment. PloS one 20120101
Short-term effects of medetomidine on photosynthesis and protein synthesis in periphyton, epipsammon and plankton communities in relation to predicted environmental concentrations. Biofouling 20120101
Venous air embolism leading to cardiac arrest in an infant with cyanotic congenital heart disease. Case reports in anesthesiology 20120101
Lung physiology and obesity: anesthetic implications for thoracic procedures. Anesthesiology research and practice 20120101
Evaluation of atherosclerotic lesions using dextran- and mannan-dextran-coated USPIO: MRI analysis and pathological findings. International journal of nanomedicine 20120101
Drug management of visceral pain: concepts from basic research. Pain research and treatment 20120101
DNA Typing of Mycobacterium bovis Isolates from Badgers (Meles meles) Culled from Areas in Ireland with Different Levels of Tuberculosis Prevalence. Veterinary medicine international 20120101
Dexmedetomidine as adjunct treatment for severe alcohol withdrawal in the ICU. Annals of intensive care 20120101
Energy requirement and food intake behaviour in young adult intact male cats with and without predisposition to overweight. TheScientificWorldJournal 20120101
Sedation in intensive care unit: Is Dexmedetomidine the best choice? International journal of critical illness and injury science 20120101
Dexmedetomidine-ketamine sedation during upper gastrointestinal endoscopy and biopsy in a patient with Duchenne muscular dystrophy and egg allergy. International journal of critical illness and injury science 20120101
Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice. PloS one 20120101
Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury. The Libyan journal of medicine 20120101
Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. International journal of nanomedicine 20120101
The effects of handling and anesthetic agents on the stress response and carbohydrate metabolism in northern elephant seals. PloS one 20120101
The effects of low-high doses of dexmedetomidine on erythrocyte deformability in rats. Bratislavske lekarske listy 20120101
Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine. Indian journal of anaesthesia 20120101
Alcoholic delirium tremens with hollow viscus perforation scheduled for emergency laparotomy. Indian journal of anaesthesia 20120101
Mechanical ventilation and the titer of antibodies as risk factors for the development of transfusion-related lung injury. Critical care research and practice 20120101
Dexmedetomidine: A look at a promising new avenue of use. Saudi journal of anaesthesia 20120101
Ultrasound-guided single injection infraclavicular brachial plexus block using bupivacaine alone or combined with dexmedetomidine for pain control in upper limb surgery: A prospective randomized controlled trial. Saudi journal of anaesthesia 20120101
Dexmedetomidine in pediatric cardiac anesthesia. Annals of cardiac anaesthesia 20120101
Dexmedetomidine controls junctional ectopic tachycardia during Tetralogy of Fallot repair in an infant. Annals of cardiac anaesthesia 20120101
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. Circulation journal : official journal of the Japanese Circulation Society 20120101
Dexmedetomidine and its increasing application in nonopioid detoxification. Journal of opioid management 20120101
Capture, anesthesia, and disturbance of free-ranging brown bears (Ursus arctos) during hibernation. PloS one 20120101
Transcatheter aortic valve replacement under monitored anesthesia care versus general anesthesia with intubation. Cardiovascular revascularization medicine : including molecular interventions 20120101
A comparison of dexmedetomidine sedation with and without midazolam for dental implant surgery. Anesthesia progress 20120101
Removal of a vertebral metastatic tumor compressing the spinal nerve roots via a single-port, transforaminal, endoscopic approach under monitored anesthesia care. Pain physician 20120101
Efficacy of intrathecally administered dexmedetomidine versus dexmedetomidine with fentanyl in patients undergoing major abdominal cancer surgery. Pain physician 20120101
Effect of the perioperative infusion of dexmedetomidine on chronic pain after breast surgery. Indian journal of palliative care 20120101
Evaluation of long-term infusion of dexmedetomidine in critically ill patients: A retrospective analysis. International journal of critical illness and injury science 20120101
Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation. Anesthesiology research and practice 20120101
Dexmedetomidine as an anesthetic adjuvant in laparoscopic surgery: An observational study using entropy monitoring. Journal of anaesthesiology, clinical pharmacology 20120101
Proton nuclear magnetic resonance and pattern recognition analysis of liver extracts from rats under different anesthetics. BMC medical imaging 20120101
Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion. PloS one 20120101
Comparison of dexmedetomidine and clonidine (α2 agonist drugs) as an adjuvant to local anaesthesia in supraclavicular brachial plexus block: A randomised double-blind prospective study. Indian journal of anaesthesia 20120101
Dexmedetomidine versus midazolam for conscious sedation in postoperative patients undergoing flexible bronchoscopy: a randomized study. The Journal of international medical research 20120101
Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure. Internal medicine (Tokyo, Japan) 20120101
Correlation between bispectral index, observational sedation scale, and lower esophageal sphincter pressure in volunteers using dexmedetomidine or propofol. Medical science monitor : international medical journal of experimental and clinical research 20120101
Sedation in traumatic brain injury. Emergency medicine international 20120101
Use of dexmedetomidine infusion in anaesthesia for awake craniotomy. Indian journal of anaesthesia 20120101
Asystole after orthotopic lung transplantation: examining the interaction of cardiac denervation and dexmedetomidine. Case reports in anesthesiology 20120101
Neurophysiological assessment of the sedative and analgesic effects of a constant rate infusion of dexmedetomidine in the dog. Veterinary journal (London, England : 1997) 20111201
Liquid chromatography tandem mass spectrometry for the simultaneous quantitative analysis of ketamine and medetomidine in ovine plasma. Biomedical chromatography : BMC 20111201
Clinical evaluation of total intravenous anesthesia using a combination of propofol and medetomidine following anesthesia induction with medetomidine, guaifenesin and propofol for castration in Thoroughbred horses. The Journal of veterinary medical science 20111201
Evaluation of medetomidine, ketamine and buprenorphine for neutering feral cats. Journal of feline medicine and surgery 20111201
Dexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass. Journal of anesthesia 20111201
Dexmedetomidine: applications for the pediatric patient with congenital heart disease. Pediatric cardiology 20111201
Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements: a randomized control trial. Journal of anesthesia 20111201
Consciousness lost and found: subjective experiences in an unresponsive state. Brain and cognition 20111201
Apparent dexmedetomidine-induced polyuric syndrome in an achondroplastic patient undergoing posterior spinal fusion. Anesthesia and analgesia 20111201
Evaluation of two sedation protocols for use before diagnostic intra-articular anaesthesia in lame dogs. The Journal of small animal practice 20111201
Use of dexmedetomidine to discontinue high-dose fentanyl. The Annals of pharmacotherapy 20111201
Consciousness versus responsiveness: insights from general anesthetics. Brain and cognition 20111201
Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral Mu antagonists. Anesthesiology clinics 20111201
Altering intensive care sedation paradigms to improve patient outcomes. Anesthesiology clinics 20111201
Sedation & immunomodulation. Anesthesiology clinics 20111201
Evaluation of dexmedetomidine and ketamine in combination with various opioids as injectable anesthetic combinations for castration in cats. Journal of the American Veterinary Medical Association 20111201
Optimal management of shivering during therapeutic hypothermia after cardiac arrest. Critical care nurse 20111201
Dexmedetomidine controls twitch-convulsive syndrome in the course of uremic encephalopathy. Journal of clinical anesthesia 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
A comparison of two field chemical immobilization techniques for bobcats (Lynx rufus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201
Evaluation of medetomidine-alfaxalone and medetomidine-ketamine in semi-free ranging Bennett's wallabies (Macropus rufogriseus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201
Evaluation of modified techniques for immobilization of wild ring-tailed lemurs (Lemur catta). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201
Clinical use of dexmedetomidine in monitored anesthesia care. Korean journal of anesthesiology 20111201
Dexmedetomidine is effective for monitored anesthesia care in outpatients undergoing cataract surgery. Korean journal of anesthesiology 20111201
Dexmedetomidine for the treatment of acute pain from complex regional pain syndrome. Korean journal of anesthesiology 20111201
Incidence of cardiac arrest increases with the indiscriminate use of dexmedetomidine: a case series and review of published case reports. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20111201
Bronchial thermoplasty: a novel treatment for severe asthma requiring monitored anesthesia care. AANA journal 20111201
Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by α2 adrenoceptor agonist dexmedetomidine. European journal of pharmacology 20111116
Evaluation of dexmedetomidine: safety and clinical outcomes in critically ill trauma patients. The Journal of trauma 20111101
The effect of dexmedetomidine during myringotomy and pressure-equalizing tube placement in children. Paediatric anaesthesia 20111101
Children with anterior mediastinal mass: procedural sedation with dexmedetomidine. European journal of anaesthesiology 20111101
Review article: Dexmedetomidine in children: current knowledge and future applications. Anesthesia and analgesia 20111101
Postoperative respiratory and analgesic effects of dexmedetomidine or morphine for adenotonsillectomy in children with obstructive sleep apnoea. Anaesthesia 20111101
Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery. Current medical research and opinion 20111101
Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats. Upsala journal of medical sciences 20111101
Hemodynamic effects of dexmedetomidine in isoflurane-anesthetized cats. Veterinary anaesthesia and analgesia 20111101
Severe cardiovascular depression in a cat following a mandibular nerve block with bupivacaine. Veterinary anaesthesia and analgesia 20111101
Evaluation of topical nalbuphine or oral tramadol as analgesics for corneal pain in dogs: a pilot study. Veterinary ophthalmology 20111101
Regional anesthesia in anticoagulated patients. Journal of clinical anesthesia 20111101
Postpartum analgesia with dexmedetomidine in opioid tolerance during pregnancy. Journal of clinical anesthesia 20111101
Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Acta anaesthesiologica Scandinavica 20111101
[Clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20111101
Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice. Journal of the American Association for Laboratory Animal Science : JAALAS 20111101
Bleeding time in healthy dogs sedated with morphine and medetomidine. The Veterinary record 20111029
Minimal driving of hippocampal theta by the supramammillary nucleus during water maze learning. Hippocampus 20111001
α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension. Basic & clinical pharmacology & toxicology 20111001
Clevidipine for controlled hypotension during spinal surgery in adolescents. Journal of neurosurgical anesthesiology 20111001
Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology 20111001
Epidural anesthesia with intravenous dexmedetomidine sedation in the successful anesthetic management of MRI-guided focused ultrasound ablation of early prostatic cancer. Journal of anesthesia 20111001
Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine, propofol, and sevoflurane. British journal of anaesthesia 20111001
A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study. Journal of pharmacokinetics and pharmacodynamics 20111001
Interaction between dexmedetomidine and α-adrenergic receptors: emphasis on vascular actions. Journal of cardiothoracic and vascular anesthesia 20111001
Postoperative delirium. part 2: detection, prevention and treatment. European journal of anaesthesiology 20111001
Sepsis-associated encephalopathy: not just delirium. Clinics (Sao Paulo, Brazil) 20111001
A review of recent clinical trials and guidelines on the prevention and management of delirium in hospitalized older patients. Hospital practice (1995) 20111001
The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia. Korean journal of anesthesiology 20111001
Effects of PEEP on the thermoregulatory responses during TIVA in patients undergoing tympanoplasty. Korean journal of anesthesiology 20111001
Use of dexmedetomidine for awake crainiotomy. Korean journal of anesthesiology 20111001
Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia. Middle East journal of anaesthesiology 20111001
Altered mental status. Continuum (Minneapolis, Minn.) 20111001
Long-term vascular access ports as a means of sedative administration in a rodent fMRI survival model. Journal of neuroscience methods 20110915
Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata. Cardiovascular research 20110901
Subeffective doses of nitroparacetamol (NCX-701) enhance the antinociceptive activity of the α₂-adrenoceptor agonist medetomidine. Pharmacology, biochemistry, and behavior 20110901
Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. British journal of anaesthesia 20110901
Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901
Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis. Paediatric anaesthesia 20110901
Effects of different doses of L-659'066 on the bispectral index and clinical sedation in dogs treated with dexmedetomidine. Veterinary anaesthesia and analgesia 20110901
Medetomidine/midazolam/ketamine anaesthesia in ferrets: effects on cardiorespiratory parameters and evaluation of plasma drug concentrations. Veterinary anaesthesia and analgesia 20110901
Short term pharmacological immobilization in macaque monkeys. Veterinary anaesthesia and analgesia 20110901
Sedation and anesthesia issues in pediatric imaging. Pediatric radiology 20110901
Intramuscular dexmedetomidine sedation for pediatric MRI and CT. AJR. American journal of roentgenology 20110901
Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. The Annals of thoracic surgery 20110901
Comparison of the effects of racemic ketamine and S-ketamine for anesthesia in Rheem gazelles (Gazella subgutturosa marica) and Subgutturosa gazelles (Gazella subgutturosa subgutturosa). American journal of veterinary research 20110901
Effect of sedation protocol on glomerular filtration rate in cats as determined by use of quantitative renal scintigraphy. American journal of veterinary research 20110901
Sedative and analgesic effects of intravenous xylazine and tramadol on horses. Journal of veterinary science 20110901
[Comparison of sedative effect of dexmedetomidine and midazolam for post-operative patients undergoing mechanical ventilation in surgical intensive care unit]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20110901
Kinetics of proinflammatory cytokines after intraperitoneal injection of tribromoethanol and a tribromoethanol/xylazine combination in ICR mice. Laboratory animal research 20110901
Sedation under JCI standard. Korean journal of anesthesiology 20110901
Anesthesia and Intensive care implications for pituitary surgery: Recent trends and advancements. Indian journal of endocrinology and metabolism 20110901
Evaluation of outcomes in patients given dexmedetomidine in functional endoscopic sinus surgery. The Annals of otology, rhinology, and laryngology 20110901
Comparison of carfentanil-xylazine and thiafentanil-medetomidine in electroejaculation of captive gaur (Bos gaurus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110901
Dexmedetomidine controls agitation and facilitates reliable, serial neurological examinations in a non-intubated patient with traumatic brain injury. Neurocritical care 20110801
The effect of medetomidine on the regional cerebral blood flow in dogs measured using Technetium-99m-Ethyl Cysteinate Dimer SPECT. Research in veterinary science 20110801
The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. Journal of veterinary pharmacology and therapeutics 20110801
Effects of different doses of remifentanil infusion on hemodynamics and recovery in children undergoing pediatric diagnostic cardiac catheterization. Journal of cardiothoracic and vascular anesthesia 20110801
Bioavailability of dexmedetomidine after intranasal administration. European journal of clinical pharmacology 20110801
Multicenter assessment of the Iowa Satisfaction with Anesthesia Scale, an instrument that measures patient satisfaction with monitored anesthesia care. Anesthesia and analgesia 20110801
Dexmedetomidine as sole agent for awake fiberoptic intubation in a patient with local anesthetic allergy. Journal of anesthesia 20110801
The effects of dexmedetomidine on regional cerebral blood flow and oxygen consumption during severe hemorrhagic hypotension in rats. Anesthesia and analgesia 20110801
Administration of dexmedetomidine alone during diagnostic cardiac catheterization in adults with congenital heart disease: two case reports. Journal of anesthesia 20110801
Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells. Journal of anesthesia 20110801
Postoperative cognitive disorders. Current opinion in critical care 20110801
[Postoperative analgesia of continuous intravenous fentanyl or dexmedetomidine for patients receiving anticoagulant therapy]. Masui. The Japanese journal of anesthesiology 20110801
How should we monitor pediatric patients with Duchenne muscular dystrophy? -A case report-. Korean journal of anesthesiology 20110801
Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Drugs 20110730
[Application of sedation with a low dose of dexmedetomidine during intrathecal anesthesia in elderly patients]. Zhonghua yi xue za zhi 20110726
Inhibition of nociceptive responses after systemic administration of amidated kyotorphin. British journal of pharmacology 20110701
Takotsubo cardiomyopathy and the difficult airway. Journal of neurosurgical anesthesiology 20110701
Limb-specific differences in the skin vascular responsiveness to adrenergic agonists. Journal of applied physiology (Bethesda, Md. : 1985) 20110701
Pediatric sedation--evolution and revolution. Paediatric anaesthesia 20110701
Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity. Cell calcium 20110701
A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats. Veterinary anaesthesia and analgesia 20110701
Cutaneous reaction after intravenous administration of medetomidine? Veterinary anaesthesia and analgesia 20110701
Dexmedetomidine for opioid and benzodiazepine withdrawal in pediatric patients. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110701
Evaluation of the sedative and cardiovascular effects of intramuscular administration of dexmedetomidine with and without concurrent atropine administration in dogs. Journal of the American Veterinary Medical Association 20110701
Anesthetic agents and complications in Vietnamese potbellied pigs: 27 cases (1999-2006). Journal of the American Veterinary Medical Association 20110701
Effective immobilizing doses of medetomidine-ketamine in free-ranging, wild Norwegian reindeer (Rangifer tarandus tarandus). Journal of wildlife diseases 20110701
Indigo carmine enhances phenylephrine-induced contractions in an isolated rat aorta. Korean journal of anesthesiology 20110701
Dexmedetomidine for the prevention of shivering during spinal anesthesia. Clinics (Sao Paulo, Brazil) 20110701
Effect of a dexmedetomidine substitution during a nationwide propofol shortage in patients undergoing coronary artery bypass graft surgery. Pharmacotherapy 20110701
Current approaches to pediatric heart catheterizations. Pediatric reports 20110630
Sedation for radiological imaging. Archives of disease in childhood. Education and practice edition 20110601
The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery. Molecular biology reports 20110601
Review article: dexmedetomidine: does it have potential in palliative medicine? The American journal of hospice & palliative care 20110601
Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol. Neurocritical care 20110601
Evaluation of the analgesic efficacy of local dexmedetomidine application. The Clinical journal of pain 20110601
Delirium and sedation in the ICU. Neurocritical care 20110601
Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters. Physiology & behavior 20110601
Analgosedation in neonates: do we still need additional tools after 30 years of clinical research? Archives of disease in childhood. Education and practice edition 20110601
Dexmedetomidine sedation for awake fiberoptic intubation of patients with difficult airways due to severe odontogenic cervicofacial infections. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110601
Dexmedetomidine: an alternative for epidural anesthesia in tension-free vaginal-tape surgery. Journal of anesthesia 20110601
Volatile agents for ICU sedation? Intensive care medicine 20110601
High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110601
Distress at induction: prevention and consequences. Current opinion in anaesthesiology 20110601
Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney. Acta cirurgica brasileira 20110601
High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety. The Annals of pharmacotherapy 20110601
Dexmedetomidine does not produce vasocontraction on human isolated gastroepiploic artery. Korean journal of anesthesiology 20110601
Dexmedetomidine as a pediatric anesthetic premedication to reduce anxiety and to deter emergence delirium. AANA journal 20110601
Determination of an optimal dose of medetomidine-ketamine-buprenorphine for anaesthesia in the Cape ground squirrel (Xerus inauris). Journal of the South African Veterinary Association 20110601
Dexmedetomidine (Precedex) for ICU sedation. The Medical letter on drugs and therapeutics 20110530
Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats. The Journal of surgical research 20110515
Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans. The Journal of physiology 20110515
Hemodynamics in coronary artery bypass surgery: effects of intraoperative dexmedetomidine administration. Der Anaesthesist 20110501
c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. Yonsei medical journal 20110501
Sedative effects of three doses of romifidine in comparison with medetomidine in cats. Veterinary anaesthesia and analgesia 20110501
A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics. Veterinary anaesthesia and analgesia 20110501
Arrhythmias and transient changes in cardiac function after topical administration of one drop of phenylephrine 10% in an adult cat undergoing conjunctival graft. Veterinary anaesthesia and analgesia 20110501
Role of α2-agonists in the treatment of acute alcohol withdrawal. The Annals of pharmacotherapy 20110501
Evaluation of dexmedetomidine and ketamine in combination with opioids as injectable anesthesia for castration in dogs. Journal of the American Veterinary Medical Association 20110501
Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers. Journal of clinical anesthesia 20110501
Dexmedetomidine and procedural sedation: the AusPAR a TGA resource. Anaesthesia and intensive care 20110501
Recent advances in pediatric anesthesia. Korean journal of anesthesiology 20110501
The effects of intraoperative infusion of dexmedetomidine on early renal function after percutaneous nephrolithotomy. Acta anaesthesiologica Scandinavica 20110501
Antidepressant-like action of intracerebral 6-fluoronorepinephrine, a selective full α-adrenoceptor agonist. The international journal of neuropsychopharmacology 20110401
Dexmedetomidine protects blood δ-aminolevulinate dehydratase from inactivation caused by hyperoxygenation in total intravenous anesthesia. Human & experimental toxicology 20110401
A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography. Journal of cardiothoracic and vascular anesthesia 20110401
Post-operative dexmedetomidine-based sedation after uneventful intracranial surgery for unruptured cerebral aneurysm: comparison with propofol-based sedation. Neurocritical care 20110401
Physiological differences between histologically defined subdivisions in the mouse auditory thalamus. Hearing research 20110401
Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats. Journal of anesthesia 20110401
Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16). Experimental physiology 20110401
Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochemistry international 20110401
Successful implementation of a pediatric sedation protocol for mechanically ventilated patients. Critical care medicine 20110401
Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers. British journal of anaesthesia 20110401
Impact of dexmedetomidine on early extubation in pediatric cardiac surgical patients. Intensive care medicine 20110401
Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine. Circulation. Cardiovascular genetics 20110401
Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children. Journal of anesthesia 20110401
The comparison of the effects of dexmedetomidine and midazolam sedation on electroencephalography in pediatric patients with febrile convulsion. Paediatric anaesthesia 20110401
Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesthesia and analgesia 20110401
Sedation with dexmedetomidine hydrochloride during endoscopic submucosal dissection of gastric cancer. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 20110401
When the decision is what to decide: using evidence inventory reports to focus health technology assessments. International journal of technology assessment in health care 20110401
[Effect of dexmedetomidine on patient-controlled intravenous analgesia with fentanyl in elderly patients after total hip replacement]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401
[Measurement of the minimum alveolar concentration of sevoflurane during combined anesthesia with sevoflurane, small-dose dexmedetomidine and fentanyl]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401
[Determination of the 50% effective concentration of dexmedetomidine as an adjuvant in combined spinal-epidural anesthesia with Narcotrend]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401
[The effect of dexmedetomidine in a child with intractable supraventricular tachyarrythmia after total cavopulmonary connection]. Masui. The Japanese journal of anesthesiology 20110401
Dexmedetomidine in cardiac surgery patients who fail extubation and present with a delirium state. The heart surgery forum 20110401
Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report. AANA journal 20110401
Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients. International journal of clinical pharmacy 20110401
Effects of α2-adrenergic drugs on small intestinal motility in the horse: an in vitro study. Veterinary journal (London, England : 1997) 20110301
Dexmedetomidine as an adjuvant analgesic for intractable cancer pain. Journal of palliative medicine 20110301
Pharmacokinetics of dexmedetomidine in Chinese post-surgical intensive care unit patients. Acta anaesthesiologica Scandinavica 20110301
Year in review in Intensive Care Medicine 2010: III. ARDS and ALI, mechanical ventilation, noninvasive ventilation, weaning, endotracheal intubation, lung ultrasound and paediatrics. Intensive care medicine 20110301
Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis). Veterinary anaesthesia and analgesia 20110301
Evaluation of the electroencephalogram in young cats. American journal of veterinary research 20110301
Comparative evaluation of halothane anaesthesia in medetomidine-butorphanol and midazolam-butorphanol premedicated water buffaloes (Bubalus bubalis). Journal of the South African Veterinary Association 20110301
Impaired spatial memory after ketamine administration in chronic low doses. Current neuropharmacology 20110301
Differences between Physostigmine- and Yohimbine-induced States Are Visualized in Canonical Space Constructed from EEG during Natural Sleep-wake Cycle in Rats. Experimental neurobiology 20110301
Physiologic evaluation of capture and anesthesia with medetomidine-zolazepam-tiletamine in brown bears (Ursus arctos). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301
Biochemical variables in free-ranging white-tailed deer (Odocoileus virginianus) after chemical immobilization in clover traps or via ground-darting. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301
Field anesthesia of wild ring-tailed lemurs (Lemur catta) using tiletamine-zolazepam, medetomidine, and butorphanol. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301
Dorsal hand vein responses to the α₁-adrenoceptor agonist phenylephrine do not predict responses to the α₂-adrenoceptor agonist dexmedetomidine. European journal of pharmacology 20110225
Functional connectivity in the rat at 11.7T: Impact of physiological noise in resting state fMRI. NeuroImage 20110214
Ultrasound guidance for the performance of sciatic and saphenous nerve blocks in dogs. Veterinary journal (London, England : 1997) 20110201
Independent regulation of α1 and α2 adrenergic receptor-mediated vasoconstriction in vivo. Journal of hypertension 20110201
One-lung ventilation and arterial oxygenation. Current opinion in anaesthesiology 20110201
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. American journal of physiology. Endocrinology and metabolism 20110201
High-dose dexmedetomidine sedation for pediatric MRI. Paediatric anaesthesia 20110201
Pediatric CT sedation: comparison of dexmedetomidine and pentobarbital. AJR. American journal of roentgenology 20110201
Dexmedetomidine use in pediatric airway reconstruction. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20110201
Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia. Middle East journal of anaesthesiology 20110201
Dexmedetomidine premedication of outpatients under IVRA. Middle East journal of anaesthesiology 20110201
Sterilisation of hybrid Galapagos tortoises (Geochelone nigra) for island restoration. Part 1: endoscopic oophorectomy of females under ketamine-medetomidine anaesthesia. The Veterinary record 20110115
Dexmedetomidine controls the hemodynamic manifestations of tourniquet pain. American journal of therapeutics 20110101
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. The journal of pain : official journal of the American Pain Society 20110101
Dexmedetomidine: pediatric pharmacology, clinical uses and safety. Expert opinion on drug safety 20110101
Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats. Neuropharmacology 20110101
Dexmedetomidine: new insights. European journal of anaesthesiology 20110101
Recovery Effects of a 180 mT Static Magnetic Field on Bone Mineral Density of Osteoporotic Lumbar Vertebrae in Ovariectomized Rats. Evidence-based complementary and alternative medicine : eCAM 20110101
Dexmedetomidine-related atrial standstill and loss of capture in a pediatric patient after congenital heart surgery. Critical care medicine 20110101
Use of dexmedetomidine for sedation in critically ill mechanically ventilated pediatric burn patients. Journal of burn care & research : official publication of the American Burn Association 20110101
3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor. Bioorganic & medicinal chemistry 20110101
Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110101
Angiotensin-converting enzyme inhibitor - An innocuous factor behind cardiac arrest following induction of anesthesia. Annals of cardiac anaesthesia 20110101
Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals. Intensive care medicine 20110101
Two doses of dexmedetomidine in combination with buprenorphine for premedication in dogs; a comparison with acepromazine and buprenorphine. Veterinary anaesthesia and analgesia 20110101
Postoperative complications in a lamb after major surgery. Veterinary anaesthesia and analgesia 20110101
A scavenging double mask to reduce workplace contamination during mask induction of inhalation anesthesia in dogs. Acta veterinaria Scandinavica 20110101
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. Journal of neuroinflammation 20110101
Clinical, genetic, and pathological features of male pseudohermaphroditism in dog. Reproductive biology and endocrinology : RB&E 20110101
The use of lorcaserin in the management of obesity: a critical appraisal. Drug design, development and therapy 20110101
Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors. Frontiers in neuroscience 20110101
Imaging of functional connectivity in the mouse brain. PloS one 20110101
Early target cells of measles virus after aerosol infection of non-human primates. PLoS pathogens 20110101
Reported analgesic administration to rabbits undergoing experimental surgical procedures. BMC veterinary research 20110101
Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. PloS one 20110101
[Dexmedetomidine for endoscopic submucosal dissection in a patient with severe chronic obstructive pulmonary disease]. Masui. The Japanese journal of anesthesiology 20110101
Transcriptome signature of the adult mouse choroid plexus. Fluids and barriers of the CNS 20110101
Effect of a small dose of propofol or ketamine to prevent coughing and laryngospasm in children awakening from general anesthesia. Korean journal of anesthesiology 20110101
Sensorimotor experience influences recovery of forelimb abilities but not tissue loss after focal cortical compression in adult rats. PloS one 20110101
Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Critical care (London, England) 20110101
The effect of window rooms on critically ill patients with subarachnoid hemorrhage admitted to intensive care. Critical care (London, England) 20110101
Dexmedetomidine and procedural sedation. Anaesthesia and intensive care 20110101
Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells. International journal of nanomedicine 20110101
Kinase activity profiling of pneumococcal pneumonia. PloS one 20110101
Infectivity to Phlebotomus perniciosus of dogs naturally parasitized with Leishmania infantum after different treatments. Parasites & vectors 20110101
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. PloS one 20110101
Novel serum proteomic signatures in a non-human primate model of retinal injury. Molecular vision 20110101
Influence of the wing-of-the-nostrils correction procedure on the change of the acid-base balance parameters and oxygen concentration in the arterial blood in French bulldogs. Polish journal of veterinary sciences 20110101
Functional connectivity fMRI of the rodent brain: comparison of functional connectivity networks in rat and mouse. PloS one 20110101
Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion. PloS one 20110101
Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. Mediators of inflammation 20110101
Iron specificity of a biosensor based on fluorescent pyoverdin immobilized in sol-gel glass. Journal of biological engineering 20110101
BOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation. PloS one 20110101
Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization. Journal of pharmacological and toxicological methods 20110101
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats. Pharmacological reports : PR 20110101
Use of α(2)-Agonists in Neuroanesthesia: An Overview. The Ochsner journal 20110101
Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC anesthesiology 20110101
Influence of a brief episode of anesthesia during the induction of experimental brain trauma on secondary brain damage and inflammation. PloS one 20110101
Anesthetic management for combined mitral valve replacement and aortic valve repair in a patient with osteogenesis imperfecta. Annals of cardiac anaesthesia 20110101
Improving delirium care in the intensive care unit: the design of a pragmatic study. Trials 20110101
Evaluation of a local ICU sedation guideline on goal-directed administration of sedatives and analgesics. Journal of pain research 20110101
Clinical Evaluation of Xylazine-Butorphanol-Guaifenesin-Ketamine as Short-Term TIVA in Equines. Veterinary medicine international 20110101
Noradrenaline and Parkinson's disease. Frontiers in systems neuroscience 20110101
Laparoscopic-Assisted Cryptorchidectomy in an Adult Reindeer (Rangifer tarandus). Veterinary medicine international 20110101
Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols. Frontiers in systems neuroscience 20110101
Dexmedetomidine versus propofol for sedation in patients undergoing vitreoretinal surgery under sub-Tenon's anesthesia. Saudi journal of anaesthesia 20110101
Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial. Critical care (London, England) 20110101
Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle. PloS one 20110101
Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. PloS one 20110101
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model. PloS one 20110101
Diaphragm muscle weakness in an experimental porcine intensive care unit model. PloS one 20110101
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Critical care (London, England) 20110101
Evidence of a pharmacodynamic EEG profile in rats following clonidine administration using a nonlinear analysis. Nonlinear biomedical physics 20110101
Emerging concepts in post-operative pain management. Indian journal of anaesthesia 20110101
Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation. Indian journal of anaesthesia 20110101
Vitamin D status and bone and connective tissue turnover in brown bears (Ursus arctos) during hibernation and the active state. PloS one 20110101
Increased local concentration of complement C5a contributes to incisional pain in mice. Journal of neuroinflammation 20110101
Preparation of pre-confluent retinal cells increases graft viability in vitro and in vivo: a mouse model. PloS one 20110101
Dexmedetomidine use during strabismus surgery in agitated children. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101
Local application of BMP-2 specific plasmids in fibrin glue does not promote implant fixation. BMC musculoskeletal disorders 20110101
Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients. Journal of anaesthesiology, clinical pharmacology 20110101
Anaesthesia of three young grey seals (Halichoerus grypus) for fracture repair. Irish veterinary journal 20110101
Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury. Critical care research and practice 20110101
Preliminary experience with dexmedetomidine in neonatal anesthesia. Journal of anaesthesiology, clinical pharmacology 20110101
A comparison of equisedative infusions of propofol and midazolam for conscious sedation during spinal anesthesia - a prospective randomized study. Journal of anaesthesiology, clinical pharmacology 20110101
Analgesic properties of a dexmedetomidine infusion after uvulopalatopharyngoplasty in patients with obstructive sleep apnea. Saudi journal of anaesthesia 20110101
Dexmedetomidine-ketamine sedation during bone marrow aspirate and biopsy in a patient with duchenne muscular dystrophy. Saudi journal of anaesthesia 20110101
Integrative review utilizing dexmedetomidine as an anesthetic for monitored anesthesia care and regional anesthesia. Nursing forum 20110101
Dangerous sedation in an obese patient. Indian journal of anaesthesia 20110101
Technical and conceptual considerations for performing and interpreting functional MRI studies in awake rats. Frontiers in psychiatry 20110101
The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys. Journal of neuroinflammation 20110101
Dexmedetomidine hydrochloride as a long-term sedative. Therapeutics and clinical risk management 20110101
Emergence of tuning to natural stimulus statistics along the central auditory pathway. PloS one 20110101
Morphine use in cancer surgery. Frontiers in pharmacology 20110101
Stimulus-specific adaptation and deviance detection in the rat auditory cortex. PloS one 20110101
Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons. PloS one 20110101
Ephedrine enhances the antinociceptive effect of dexmedetomidine in mice. Neuro endocrinology letters 20110101
Dexmedetomidine: New avenues. Journal of anaesthesiology, clinical pharmacology 20110101
Anesthesia for joint replacement surgery: Issues with coexisting diseases. Journal of anaesthesiology, clinical pharmacology 20110101
A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine. Journal of anaesthesiology, clinical pharmacology 20110101
Comparative study of intravenously administered clonidine and magnesium sulfate on hemodynamic responses during laparoscopic cholecystectomy. Journal of anaesthesiology, clinical pharmacology 20110101
Comparison of dexmedetomidine and three different doses of midazolam in preoperative sedation. Journal of anaesthesiology, clinical pharmacology 20110101
Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: image registration approach. PloS one 20110101
Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PloS one 20110101
Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium: a post-hoc analysis of a double-blind, randomized, placebo-controlled study. Critical care (London, England) 20110101
Transient inactivation of the medial prefrontal cortex affects both anxiety and decision-making in male wistar rats. Frontiers in neuroscience 20110101
Additives to local anesthetics for peripheral nerve blockade. International anesthesiology clinics 20110101
A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Saudi journal of anaesthesia 20110101
Dexmedetomidine use in the setting of cocaine-induced hypertensive emergency and aortic dissection: a novel indication. Case reports in medicine 20110101
MIQuant--semi-automation of infarct size assessment in models of cardiac ischemic injury. PloS one 20110101
Anesthetic Routines: The Anesthesiologist's Role in GI Recovery and Postoperative Ileus. Advances in preventive medicine 20110101
Dexmedetomidine in anaesthesia practice: A wonder drug? Indian journal of anaesthesia 20110101
Effects of dexmedetomidine added to caudal ropivacaine in paediatric lower abdominal surgeries. Indian journal of anaesthesia 20110101
Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia. Indian journal of anaesthesia 20110101
Dexmedetomidine attenuates sympathoadrenal response to tracheal intubation and reduces perioperative anaesthetic requirement. Indian journal of anaesthesia 20110101
Inverse agonism and its therapeutic significance. Indian journal of pharmacology 20110101
Effects of dexmedetomidine on oxygenation during one-lung ventilation for thoracic surgery in adults. Journal of minimal access surgery 20110101
Robust reproducible resting state networks in the awake rodent brain. PloS one 20110101
Assessing antiangiogenic therapy response by DCE-MRI: development of a physiology driven multi-compartment model using population pharmacometrics. PloS one 20110101
Subcutaneous dissociative conscious sedation (sDCS) an alternative method for airway regional blocks: a new approach. BMC anesthesiology 20110101
Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients. Critical care (London, England) 20110101
Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala. PloS one 20110101
Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Experimental animals 20110101
Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat. Molecular pain 20110101
Comparison of intravenous medetomidine and medetomidine/ketamine for immobilization of free-ranging variable flying foxes (Pteropus hypomelanus). PloS one 20110101
Optimized mouse model for the imaging of tumor metastasis upon experimental therapy. PloS one 20110101
A systematic review of the effects of sedatives and anesthetics in patients with obstructive sleep apnea. Journal of anaesthesiology, clinical pharmacology 20110101
Role of hydrocortisone in prevention of pain on propofol injection. Journal of anaesthesiology, clinical pharmacology 20110101
Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine. Journal of anaesthesiology, clinical pharmacology 20110101
Anesthetic considerations in acute spinal cord trauma. International journal of critical illness and injury science 20110101
Comparison of an intraoperative infusion of dexmedetomidine or remifentanil on perioperative haemodynamics, hypnosis and sedation, and postoperative pain control. The Journal of international medical research 20110101
Comparative evaluation of dexmedetomidine and fentanyl for epidural analgesia in lower limb orthopedic surgeries. Saudi journal of anaesthesia 20110101
Preanesthetic medication in children: A comparison of intranasal dexmedetomidine versus oral midazolam. Saudi journal of anaesthesia 20110101
Procedural sedation: A review of sedative agents, monitoring, and management of complications. Saudi journal of anaesthesia 20110101
Dexmedetomidine as the primary anesthetic agent during cardiac surgery in an infant with a family history of malignant hyperthermia. Saudi journal of anaesthesia 20110101
Application of medical gases in the field of neurobiology. Medical gas research 20110101
Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia. Journal of opioid management 20110101
Preparation of the patient and the airway for awake intubation. Indian journal of anaesthesia 20110101
Epidural Auditory Event-Related Potentials in the Rat to Frequency and duration Deviants: Evidence of Mismatch Negativity? Frontiers in psychology 20110101
Culling-induced changes in badger (Meles meles) behaviour, social organisation and the epidemiology of bovine tuberculosis. PloS one 20110101
Therapeutic hypothermia in stroke and traumatic brain injury. Frontiers in neurology 20110101
Chirality and anaesthetic drugs: A review and an update. Indian journal of anaesthesia 20110101
Changes in intraocular pressure following administration of suxamethonium and endotracheal intubation: Influence of dexmedetomidine premedication. Indian journal of anaesthesia 20110101
Postoperative complications after thoracic surgery in the morbidly obese patient. Anesthesiology research and practice 20110101
Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice. Neural systems & circuits 20110101
Dexmedetomidine infusion to facilitate opioid detoxification and withdrawal in a patient with chronic opioid abuse. Indian journal of palliative care 20110101
Short-term effects of ketamine and isoflurane on left ventricular ejection fraction in an experimental Swine model. ISRN cardiology 20110101
Dexmedetomidine as part of balanced anesthesia care in children with malignant hyperthermia risk and egg allergy. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20110101
Sudden Tracheal Collapse during EGD and Subsequent Anesthetic Management with Dexmedetomidine-Ketamine in a Patient with Achalasia and Tracheomalacia. Case reports in anesthesiology 20110101
Successful treatment of acute mania and perineal abscess using dexmedetomidine sedation as adjunctive therapy. BMJ case reports 20110101
A comparison of acepromazine-buprenorphine and medetomidine-buprenorphine for preanesthetic medication of dogs. Journal of the American Veterinary Medical Association 20101215
Premedication with dexmedetomidine alone or together with 0.5% lidocaine for IVRA. The Journal of surgical research 20101201
Successful treatment of ifosfamide neurotoxicity with dexmedetomidine. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20101201
Case report: Spinal anesthesia by mini-laminotomy for a patient with ankylosing spondylitis who was difficult to anesthetize. Clinical orthopaedics and related research 20101201
Alpha-2 agonists in acute pain management. Expert opinion on pharmacotherapy 20101201
Management of a tumor in the distal trachea while maintaining spontaneous ventilation. Journal of anesthesia 20101201
Dexmedetomidine versus fentanyl as adjuvant to propofol: comparative study in children undergoing extracorporeal shock wave lithotripsy. European journal of anaesthesiology 20101201
Alpha-2 agonists to reduce vasopressor requirements in septic shock? Medical hypotheses 20101201
Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation 20101201
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. The Journal of pharmacology and experimental therapeutics 20101201
Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Critical care medicine 20101201
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block. Anesthesia and analgesia 20101201
Dexmedetomidine-ketamine and midazolam-ketamine combinations for sedation in pediatric patients undergoing extracorporeal shock wave lithotripsy: a randomized prospective study. Journal of anesthesia 20101201
Dexmedetomidine infusion for the management of opioid-induced hyperalgesia. Pain medicine (Malden, Mass.) 20101201
Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms. Medical & biological engineering & computing 20101201
Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn. The Journal of pharmacy and pharmacology 20101201
Alpha-2 agonists as pain therapy in horses. The Veterinary clinics of North America. Equine practice 20101201
Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization. Anesthesia and analgesia 20101201
Dexmedetomidine: clinical application as an adjunct for intravenous regional anesthesia. Anesthesiology clinics 20101201
All this confusion is killin' me. Critical care medicine 20101201
Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient. Journal of anesthesia 20101201
Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice. Journal of veterinary science 20101201
Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice. Mammalian genome : official journal of the International Mammalian Genome Society 20101201
A protocol for managing urethral obstruction in male cats without urethral catheterization. Journal of the American Veterinary Medical Association 20101201
Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center. Critical pathways in cardiology 20101201
Prevalence of henipavirus and rubulavirus antibodies in pteropid bats, Papua New Guinea. Emerging infectious diseases 20101201
Dexmedetomidine: exploring its potential role and dosing guideline for its use in intractable pain in the palliative care setting. Journal of pain & palliative care pharmacotherapy 20101201
Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report. AANA journal 20101201
Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery. The Ceylon medical journal 20101201
Gene expression profiling in rodent models for schizophrenia. Current neuropharmacology 20101201
Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat. BJU international 20101101
Patient-controlled sedation: a novel approach to sedation management for mechanically ventilated patients. Chest 20101101
Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling. Neurochemistry international 20101101
Comparison of local anaesthesia with dexmedetomidine sedation and general anaesthesia during septoplasty. European journal of anaesthesiology 20101101
Comment on dexmedetomidine systematic review and meta-analysis methodology. Intensive care medicine 20101101
Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury. Intensive care medicine 20101101
Effects of two fractions of inspired oxygen on lung aeration and gas exchange in cats under inhalant anaesthesia. Veterinary anaesthesia and analgesia 20101101
Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo). Veterinary anaesthesia and analgesia 20101101
Combined paravertebral plexus block and parasacral sciatic block in healthy dogs. Veterinary anaesthesia and analgesia 20101101
Midazolam enhances the analgesic properties of dexmedetomidine in the rat. Veterinary anaesthesia and analgesia 20101101
Dexmedetomidine and ketamine for sedation during spinal anesthesia in children. Journal of clinical anesthesia 20101101
[Retrospective evaluation of dexmedetomidine for postoperative sedation in patients for cerebral aneurysm surgery]. Masui. The Japanese journal of anesthesiology 20101101
Heterotopic heart transplantation in rats: improved anesthetic and surgical technique. Transplantation proceedings 20101101
[Some adjuvants added to local anesthetics improve the duration and quality of epidural anesthesia]. Masui. The Japanese journal of anesthesiology 20101101
Cell type-specific thalamic innervation in a column of rat vibrissal cortex. Cerebral cortex (New York, N.Y. : 1991) 20101001
Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex. Cerebral cortex (New York, N.Y. : 1991) 20101001
Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery. Journal of anesthesia 20101001
Awake intubation under sedation using target-controlled infusion of dexmedetomidine: five case reports. Journal of anesthesia 20101001
Brain tissue oxygenation during dexmedetomidine administration in surgical patients with neurovascular injuries. Journal of neurosurgical anesthesiology 20101001
Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis. Clinical and experimental pharmacology & physiology 20101001
Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy. Anesthesia and analgesia 20101001
Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence. Magnetic resonance in medicine 20101001
The effects of L-659,066, a peripheral α2-adrenoceptor antagonist, and verapamil on the cardiovascular influences of dexmedetomidine in conscious sheep. Journal of veterinary pharmacology and therapeutics 20101001
Patient agitation and dexmedetomidine. The Nurse practitioner 20101001
[The role of dexmedetomidine in treatment of serious patients in intensive care unit]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101001
Spinal anesthesia: how can we improve patient satisfaction? Korean journal of anesthesiology 20101001
Creating the animated intensive care unit. Critical care medicine 20101001
Effects of medetomidine-midazolam-fentanyl IV bolus injections and its reversal by specific antagonists on cardiovascular function in rabbits. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20101001
[The use of dexmedetomidine hydrochloride in intensive care unit]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101001
Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901
Cognitive improvement during continuous sedation in critically ill, awake and responsive patients: the Acute Neurological ICU Sedation Trial (ANIST). Intensive care medicine 20100901
Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat. Magnetic resonance imaging 20100901
Dexmedetomidine for awake fibreoptic intubation and awake self-positioning in a patient with a critically located cervical lesion for surgical removal of infra-tentorial tumour. Anaesthesia 20100901
Optimal timing for the administration of intranasal dexmedetomidine for premedication in children. Anaesthesia 20100901
Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes. Veterinary anaesthesia and analgesia 20100901
Ultrasound-guided nerve blocks of the pelvic limb in dogs. Veterinary anaesthesia and analgesia 20100901
Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors. The European journal of neuroscience 20100901
Dexmedetomidine and pulmonary artery pressure in the pediatric cardiac surgery patient--A new insight. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901
Dexmedetomidine as a postoperative sedative after congenital cardiac surgery--Consideration of the anesthetic management has an important role. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901
Electroretinography in the western gray kangaroo (Macropus fuliginosus). Veterinary ophthalmology 20100901
Dexmedetomidine-ketamine combination mitigates pulmonary type-2 cationic amino acid transporter isozymes upregulation in hemorrhagic shock rats. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20100901
Rocuronium-induced neuromuscular block after long pretreatment of clonidine in rabbits. Korean journal of anesthesiology 20100901
Human exposures to immobilising agents: results of an online survey. The Veterinary record 20100828
Comparison of anaesthetic and cardiorespiratory effects of xylazine or medetomidine in combination with tiletamine/zolazepam in pigs. The Veterinary record 20100814
Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomedical chromatography : BMC 20100801
Dexmedetomidine for anesthetic management of anterior mediastinal mass. Journal of anesthesia 20100801
Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty. Journal of anesthesia 20100801
The effects of intravenous dexmedetomidine on spinal hyperbaric ropivacaine anesthesia. Journal of anesthesia 20100801
Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. Molecular pharmacology 20100801
Anaesthesia or sedation for MRI in children. Current opinion in anaesthesiology 20100801
Colour and melanophore function in rainbow trout after long term exposure to the new antifoulant medetomidine. Chemosphere 20100801
The effect of intraoperative dexmedetomidine on postoperative analgesia and sedation in pediatric patients undergoing tonsillectomy and adenoidectomy. Anesthesia and analgesia 20100801
Dexmedetomidine in the care of critically ill patients from 2001 to 2007: an observational cohort study. Anesthesiology 20100801
Visual P2-N2 complex and arousal at the time of encoding predict the time domain characteristics of amnesia for multiple intravenous anesthetic drugs in humans. Anesthesiology 20100801
Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology 20100801
High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. British journal of pharmacology 20100801
Dexmedetomidine sedation for awake tracheotomy: case report and literature review. Journal of clinical anesthesia 20100801
Prolonged infusions of dexmedetomidine in critically ill patients. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801
Pharmacologic options for reducing the shivering response to therapeutic hypothermia. Pharmacotherapy 20100801
[Two cases of cervical carotid artery stenosis with high risk post-operative hyperperfusion treated with dexmedetomidine after carotid endarterectomy]. No shinkei geka. Neurological surgery 20100801
Emergence agitation/delirium: we still don't know. Korean journal of anesthesiology 20100801
Considerations for the use of anesthetics in neurotoxicity studies. Comparative medicine 20100801
Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain. Acta anaesthesiologica Scandinavica 20100701
Effect of epidural dexmedetomidine on intraoperative awareness and post-operative pain after one-lung ventilation. Acta anaesthesiologica Scandinavica 20100701
Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes. Planta medica 20100701
In vitro evaluation of fresh sperm quality in tomcats: a comparison of two collection techniques. Theriogenology 20100701
Delayed awakening in dystonia patients undergoing deep brain stimulation surgery. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100701
Tissue restoration after implantation of polyglycolide, polydioxanone, polylevolactide, and metallic pins in cortical bone: an experimental study in rabbits. Calcified tissue international 20100701
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation. European journal of anaesthesiology 20100701
Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies. Veterinary anaesthesia and analgesia 20100701
Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs. Veterinary anaesthesia and analgesia 20100701
Baseline normal values and phylogenetic class of the electrocardiogram of anesthetized free-ranging brown bears (Ursus arctos). Journal of wildlife diseases 20100701
Use of dexmedetomidine in sustained ventricular tachycardia. Anaesthesia and intensive care 20100701
Anesthesia with intraperitoneal propofol, medetomidine, and fentanyl in rats. Journal of the American Association for Laboratory Animal Science : JAALAS 20100701
[The effect of perioperative infused dexmedetomidine on postoperative analgesic consumption in mastoidectomy operations]. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20100701
[Comparison of the activity and reliability of intravenous administration of midazolam and dexmedetomidine on sedation levels under epidural anesthesia]. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20100701
Acupuncture effects on cardiac functions measured by cardiac magnetic resonance imaging in a feline model. Evidence-based complementary and alternative medicine : eCAM 20100601
Ten Years Evidence-based High-Tech Acupuncture Part 3: A Short Review of Animal Experiments. Evidence-based complementary and alternative medicine : eCAM 20100601
Dexmedetomidine and the successful management of electroconvulsive therapy postictal agitation: a case report. The journal of ECT 20100601
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine. Burns : journal of the International Society for Burn Injuries 20100601
Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovascular research 20100601
Experience with a naphthylmedetomidine-ketamine-hyaluronidase combination in inducing immobilization in anthropoid apes. Journal of medical primatology 20100601
High field BOLD response to forepaw stimulation in the mouse. NeuroImage 20100601
Evaluating the use of dexmedetomidine in neurocritical care patients. Neurocritical care 20100601
Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis. Intensive care medicine 20100601
The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100601
Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children. Paediatric anaesthesia 20100601
Incidence and predictors of hypertension during high-dose dexmedetomidine sedation for pediatric MRI. Paediatric anaesthesia 20100601
Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery. Anesthesiology 20100601
Intensive care unit delirium. Critical care nursing clinics of North America 20100601
[Anesthetic management of laser surgery using PCPS for tracheal tumor]. Masui. The Japanese journal of anesthesiology 20100601
Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS biology 20100601
Use of thiafentanil-medetomidine for the induction of anesthesia in emus (Dromaius novaehollandiae) within a wild animal park. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601
Evaluation of medetomidine-ketamine-butorphanol anesthesia with atipamezole-naltrexone antagonism in captive male guanacos (Lama guanicoe). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601
Reversible immobilization of giant otters (Pteronura brasiliensis) using medetomidine-ketamine and atipamezole. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601
Is it safe to use propofol in the emergency department? A randomized controlled trial to compare propofol and midazolam. International journal of emergency medicine 20100601
Chronic detachable headphones for acoustic stimulation in freely moving animals. Journal of neuroscience methods 20100530
The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour. Psychoneuroendocrinology 20100501
Sedation management in Australian and New Zealand intensive care units: doctors' and nurses' practices and opinions. American journal of critical care : an official publication, American Association of Critical-Care Nurses 20100501
The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli. NeuroImage 20100501
Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease. Intensive care medicine 20100501
Brief sounds evoke prolonged responses in anesthetized ferret auditory cortex. Journal of neurophysiology 20100501
Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus). Veterinary anaesthesia and analgesia 20100501
Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine. Veterinary anaesthesia and analgesia 20100501
The hemodynamic effects of medetomidine continuous rate infusions in the dog. Veterinary anaesthesia and analgesia 20100501
A prospective, randomized, placebo-controlled study evaluating the efficacy of dexmedetomidine for sedation during vascular procedures. Vascular and endovascular surgery 20100501
Dexmedetomidine hemodynamics in children after cardiac surgery. Paediatric anaesthesia 20100501
Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis. Acta pharmacologica Sinica 20100501
Combination of high-dose dexmedetomidine sedation and fascia iliaca compartment block for hip fracture surgery. Journal of clinical anesthesia 20100501
Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesthesia and analgesia 20100501
Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants. The Kaohsiung journal of medical sciences 20100501
Anesthesia in shelter medicine. Topics in companion animal medicine 20100501
Anesthetic considerations in orthopedic patients with or without trauma. Topics in companion animal medicine 20100501
Delayed pneumothorax and contralateral hydrothorax induced by a left subclavian central venous catheter: a case report. Clinics (Sao Paulo, Brazil) 20100501
Effective and safe anesthesia for Yorkshire and Yucatan swine with and without cardiovascular injury and intervention. Journal of the American Association for Laboratory Animal Science : JAALAS 20100501
[A combination of dexmedetomidine with ketamine and opioids results in significant inhibition of hemodynamic changes associated with laparoscopic cholecystectomy and in prolongation of postoperative analgesia]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20100501
Intranasal naltrexone and atipamezole for reversal of white-tailed deer immobilized with carfentanil and medetomidine. The Canadian veterinary journal = La revue veterinaire canadienne 20100501
No increase of the blood oxygenation level-dependent functional magnetic resonance imaging signal with higher field strength: implications for brain activation studies. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100414
The effectiveness of dexmedetomidine in experimental spinal cord injury compared to methylprednisolone in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100401
Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice. Pflugers Archiv : European journal of physiology 20100401
Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy. Acta cirurgica brasileira 20100401
Propofol/dexmedetomidine and propofol/ketamine combinations for anesthesia in pediatric patients undergoing transcatheter atrial septal defect closure: a prospective randomized study. Clinical therapeutics 20100401
Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. Equine veterinary journal 20100401
Anesthetic management of a pituitary tumor resection with dexmedetomidine. AANA journal 20100401
Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease. Biochemical and biophysical research communications 20100326
The alpha(2)-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input. European journal of pharmacology 20100310
Overview of total intravenous anesthesia in children. Paediatric anaesthesia 20100301
Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats. Acta anaesthesiologica Scandinavica 20100301
Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair. European journal of anaesthesiology 20100301
Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children undergoing hypospadius surgery. European journal of anaesthesiology 20100301
Sedation trends in the 21st century: the transition to dexmedetomidine for radiological imaging studies. Paediatric anaesthesia 20100301
Dexmedetomidine: perioperative applications in children. Paediatric anaesthesia 20100301
Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomidate: a randomized, double-blind controlled trial. The Journal of surgical research 20100301
A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation. Anaesthesia 20100301
Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching. Intensive care medicine 20100301
[Incidence and duration of postoperative delirium after cardiac surgery : Comparison between dexmedetomidine and morphine for postoperative sedation and analgesia]. Der Anaesthesist 20100301
[Effect of the initial loading dose of dexmedetomidine on hemodynamics in pediatric patients undergoing cardiac surgery]. Masui. The Japanese journal of anesthesiology 20100301
Cardiopulmonary and isoflurane-sparing effects of epidural or intravenous infusion of dexmedetomidine in cats undergoing surgery with epidural lidocaine. Veterinary anaesthesia and analgesia 20100301
Combination of dexmedetomidine with buprenorphine enhances the antinociceptive effect to a thermal stimulus in the cat compared with either agent alone. Veterinary anaesthesia and analgesia 20100301
Dexmedetomidine and magnesium sulfate in the perioperative management of a child undergoing laparoscopic resection of bilateral pheochromocytomas. Journal of clinical anesthesia 20100301
Recent advances in postoperative pain management. The Yale journal of biology and medicine 20100301
Dexmedetomidine infusion during surgery in patients with a pheochromocytoma. Acta anaesthesiologica Scandinavica 20100301
The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20100301
Immobilization of red fox (Vulpes vulpes) with medetomidine-ketamine or medetomidine-midazolam and antagonism with atipamezole. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301
Comparison of the anesthetic effects of oral transmucosal versus injectable medetomidine in combination with tiletamine-zolazepam for immobilization of chimpanzees (Pan troglodytes). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301
Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception. European journal of pain (London, England) 20100201
A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Critical care medicine 20100201
Use of dexmedetomidine for primary sedation in a general intensive care unit. Critical care nurse 20100201
Effects of serial anesthesia using ketamine or ketamine/medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca mulatta). Journal of medical primatology 20100201
Airway catastrophes. Current opinion in anaesthesiology 20100201
The effect of daily repeated sedation using ketamine or ketamine combined with medetomidine on physiology and anesthetic characteristics in rhesus macaques. Journal of medical primatology 20100201
A comparison of propofol and dexmedetomidine for intravenous sedation: a randomized, crossover study of the effects on the central and autonomic nervous systems. Anesthesia and analgesia 20100201
Dexmedetomidine for procedural sedation in the emergency department. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100201
Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. Journal of hypertension 20100201
Assessing the comparative value of sedatives in the intensive care unit. Critical care medicine 20100201
Characterization of the postconditioning effect of dexmedetomidine in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation. Anesthesiology 20100201
Prolonged recovery associated with dexmedetomidine when used as a sole sedative agent in office-based oral and maxillofacial surgery procedures. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100201
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain : a journal of neurology 20100201
[Respiratory management for a patient with a giant bulla and pulmonary dysfunction during off-pump coronary artery bypass grafting]. Masui. The Japanese journal of anesthesiology 20100201
Buccal administration of dexmedetomidine as a preanesthetic in children. Journal of anesthesia 20100201
Dexmedetomidine is an excellent agent for sedation status-post lung transplant. Journal of clinical anesthesia 20100201
A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation. Journal of clinical anesthesia 20100201
Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient. Journal of clinical anesthesia 20100201
Use of dexmedetomidine as the main anesthetic agent in patients with laryngo-tracheomalacia--a case report. Middle East journal of anaesthesiology 20100201
Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs. Journal of veterinary pharmacology and therapeutics 20100201
Effect of ketamine versus thiopental sodium anesthetic induction and a small dose of fentanyl on emergence agitation after sevoflurane anesthesia in children undergoing brief ophthalmic surgery. Korean journal of anesthesiology 20100201
The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation. European journal of anaesthesiology 20100101
Dexmedetomidine sedation in children after cardiac surgery. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101
Evaluation of three immobilization combinations in the capybara (Hydrochoerus hydrochaeris). Zoo biology 20100101
Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesthesia and analgesia 20100101
Peri-operative use of dexmedetomidine in airway reconstruction surgery for obstructive sleep apnoea. The Journal of laryngology and otology 20100101
The sedative effects of low-dose medetomidine and butorphanol alone and in combination intravenously in dogs. Veterinary anaesthesia and analgesia 20100101
Alfaxalone induction dose following administration of medetomidine and butorphanol in the dog. Veterinary anaesthesia and analgesia 20100101
New insights about an old foe. Anesthesiology 20100101
Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers. Anesthesiology 20100101
Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20100101
Withdrawal from multiple sedative agent therapy in an infant: is dexmedetomidine the cause or the cure? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101
Dexmedetomidine and pediatric (cardiac) critical care--are we there yet? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101
Dexmedetomidine: are tolerance and withdrawal going to be an issue with long-term infusions? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101
Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice. PloS one 20100101
Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG. Annals of cardiac anaesthesia 20100101
Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. Journal of visualized experiments : JoVE 20100101
Dexmedetomidine in the neurointensive care unit. Discovery medicine 20100101
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat. Cardiovascular diabetology 20100101
Novel use of intraoperative dexmedetomidine infusion for sedation during spinal cord stimulator lead placement via surgical laminectomy. Pain physician 20100101
Comparison of the effects of ketamine, ketamine-medetomidine, and ketamine-midazolam on physiologic parameters and anesthesia-induced stress in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. Journal of the American Association for Laboratory Animal Science : JAALAS 20100101
A comparison of epidural anesthesia and lumbar plexus-sciatic nerve blocks for knee surgery. Clinics (Sao Paulo, Brazil) 20100101
Effect of dexmedetomidine on testicular torsion/detorsion damage in rats. Urologia internationalis 20100101
[Effect of dexmedetomidine on bispectral index and auditory evoked potential index during anesthesia with target controlled infusion of propofol and remifentanyl]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101
Responses in fish exposed to medetomidine, a new antifouling agent. Marine environmental research 20100101
Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report. Journal of medical case reports 20100101
The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients. Anaesthesia and intensive care 20100101
Optimizing sustained use of sedation in mechanically ventilated patients: focus on safety. Current drug safety 20100101
Effect of levosimendan in experimental verapamil-induced myocardial depression. Scandinavian journal of trauma, resuscitation and emergency medicine 20100101
Intensive Care Unit-acquired infection as a side effect of sedation. Critical care (London, England) 20100101
Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Critical care (London, England) 20100101
Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs. PloS one 20100101
Nicotine withdrawal and agitation in ventilated critically ill patients. Critical care (London, England) 20100101
A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety. Critical care (London, England) 20100101
The environmental fate and effects of antifouling paint biocides. Biofouling 20100101
Prevalence of radiographic detectable intervertebral disc calcifications in Dachshunds surgically treated for disc extrusion. Acta veterinaria Scandinavica 20100101
Effects of anesthetic protocol on normal canine brain uptake of 18F-FDG assessed by PET/CT. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20100101
The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs. Physiological research 20100101
Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures. Therapeutics and clinical risk management 20100101
Retrospective study of salinomycin toxicosis in 66 cats. Veterinary medicine international 20100101
Postmortem Evaluation of Left Flank Laparoscopic Access in an Adult Female Giraffe (Giraffa camelopardalis). Veterinary medicine international 20100101
Beneficial effects of loxapine on agitation and breathing patterns during weaning from mechanical ventilation. Critical care (London, England) 20100101
Evaluation of the hypnotic and hemodynamic effects of dexmedetomidine on propofol-sedated swine. Experimental animals 20100101
Sedation and anesthesia options for pediatric patients in the radiation oncology suite. International journal of pediatrics 20100101
Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care. Critical care (London, England) 20100101
Platelet function in brown bear (Ursus arctos) compared to man. Thrombosis journal 20100101
Obstructive sleep apnoea syndrome in children and anaesthesia. Indian journal of anaesthesia 20100101
A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation. American journal of therapeutics 20100101
Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys. Journal of pharmacological and toxicological methods 20100101
Diagnostic accuracy and optimal use of three tests for tuberculosis in live badgers. PloS one 20100101
Description of the type of chemical restraint used by French veterinarians to perform hip dysplasia screening radiographs. A retrospective study based on 3302 radiographs. Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20100101
The complex interplay between delirium, sepsis and sedation. Critical care (London, England) 20100101
The use of sub-anesthetic intravenous ketamine and adjuvant dexmedetomidine when treating acute pain from CRPS. Pain physician 20100101
Professional skills and competence for safe and effective procedural sedation in children: recommendations based on a systematic review of the literature. International journal of pediatrics 20100101
Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass. Revista brasileira de anestesiologia 20100101
Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia. PloS one 20100101
Effect of nitrous oxide on pain due to rocuronium injection: A randomised, double-blind, controlled clinical trial. Indian journal of anaesthesia 20100101
Procedural sedation analgesia. Saudi journal of anaesthesia 20100101
Perioperative care of an adolescent with postural orthostatic tachycardia syndrome. Saudi journal of anaesthesia 20100101
Post-Operative Narrow Complex Tachycardia: What is the Mechanism? Indian pacing and electrophysiology journal 20100101
Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia. Vascular pharmacology 20100101
Sedation and analgesia in children with developmental disabilities and neurologic disorders. International journal of pediatrics 20100101
Electrodiagnostic examination of the tibial nerve in clinically normal ferrets. Veterinary medicine international 20100101
Alpha-2 adrenoceptor agonists and sepsis: improved survival? Critical care (London, England) 20100101
Clearing up the confusion: the results of two pilot studies of antipsychotics for ICU delirium. Critical care (London, England) 20100101
Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC neuroscience 20100101
Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block. Regional anesthesia and pain medicine 20100101
Anesthesia for pediatric deep brain stimulation. Anesthesiology research and practice 20100101
Effects of Dexmedetomidine-Fentanyl Infusion on Blood Pressure and Heart Rate during Cardiac Surgery in Children. Anesthesiology research and practice 20100101
A comparison of intravenous sedation with two doses of dexmedetomidine: 0.2 µg/kg/hr Versus 0.4 µg/kg/hr. Anesthesia progress 20100101
Extended infusion of dexmedetomidine to an infant at sixty times the intended rate. International journal of pediatrics 20100101
Management of pain in children with burns. International journal of pediatrics 20100101
Head and neck cancer in the elderly: a retrospective study over 10 years (1999 - 2008). Head & neck oncology 20100101
Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs. Veterinary therapeutics : research in applied veterinary medicine 20100101
Pharmacological Preconditioning with GYKI 52466: A Prophylactic Approach to Neuroprotection. Frontiers in neuroscience 20100101
Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent. Mediators of inflammation 20100101
Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10. PloS one 20100101
Pediatric sedation: a global challenge. International journal of pediatrics 20100101
Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. Molecular vision 20100101
Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation. Molecular pain 20100101
Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8. PloS one 20100101
Analysis of heart rate variability dynamics during propofol and dexmedetomidine anesthesia. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20100101
Year in review 2009: Critical Care--shock. Critical care (London, England) 20100101
Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain. BMC molecular biology 20100101
Clinical review: the ABC of weaning failure--a structured approach. Critical care (London, England) 20100101
Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation. Journal of neuroinflammation 20100101
Pushing the envelope to reduce sedation in critically ill patients. Critical care (London, England) 20100101
Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior. Frontiers in behavioral neuroscience 20100101
Perioperative care following complex laryngotracheal reconstruction in infants and children. Saudi journal of anaesthesia 20100101
Comparative analgesic efficacy of buprenorphine or clonidine with bupivacaine in the caesarean section. Indian journal of anaesthesia 20100101
Acute pain management in children. Journal of pain research 20100101
Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway. PloS one 20100101
Vitreous humour extrusion after suxamethonium induction of anaesthesia in a polytraumatized patient: a case report. Case reports in medicine 20100101
A randomized controlled double-blinded prospective study of the efficacy of clonidine added to bupivacaine as compared with bupivacaine alone used in supraclavicular brachial plexus block for upper limb surgeries. Indian journal of anaesthesia 20100101
A rodent model of schizophrenia reveals increase in creatine kinase activity with associated behavior changes. Oxidative medicine and cellular longevity 20100101
Use of dexmedetomidine for pain control. F1000 medicine reports 20100101
Acetaldehyde-reinforcing effects: a study on oral self-administration behavior. Frontiers in psychiatry 20100101
Clonidine in adults as a sedative agent in the intensive care unit. Journal of anaesthesiology, clinical pharmacology 20100101
Dexmedetomidine: Are There Going to be Issues with Prolonged Administration? The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20100101
Dexmedetomidine use in pediatric intensive care and procedural sedation. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20100101
Evaluation of adverse events noted in children receiving continuous infusions of dexmedetomidine in the intensive care unit. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20100101
Neurologic withdrawal symptoms following abrupt discontinuation of a prolonged dexmedetomidine infusion in a child. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20100101
Dexmedetomidine to control agitation and delirium from toxic ingestions in adolescents. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20100101
Determination of dexmedetomidine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20091205
Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. Journal of critical care 20091201
ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. Neurochemistry international 20091201
Re: The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage (Cosar et al. Surg Neurol 2009;71:54-59). Surgical neurology 20091201
Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Critical care medicine 20091201
A new dosing protocol reduces dexmedetomidine-associated hypotension in critically ill surgical patients. Journal of critical care 20091201
Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models. Naunyn-Schmiedeberg's archives of pharmacology 20091201
The correlation between bispectral index and observational sedation scale in volunteers sedated with dexmedetomidine and propofol. Anesthesia and analgesia 20091201
Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: a pilot study. Journal of critical care 20091201
An updated focused review of dexmedetomidine in adults. The Annals of pharmacotherapy 20091201
A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery. Saudi medical journal 20091201
Impact of dexmedetomidine on analgesic requirements in patients after cardiac surgery in a fast-track recovery room setting. Pharmacotherapy 20091201
Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literature. Pharmacotherapy 20091201
Awake laminotomy and discectomy using Dexmedetomidine as anesthetic. Puerto Rico health sciences journal 20091201
Effects of dexmedetomidine sedation on the EEG in children. Paediatric anaesthesia 20091201
[Effect of dexmedetomidine on anesthetic requirements in cardiovascular surgery]. Masui. The Japanese journal of anesthesiology 20091201
[Apnea and severe respiratory depression induced by dexmedetomidine after general anesthesia in intensive care unit]. Masui. The Japanese journal of anesthesiology 20091201
Surgical castration of subadult giraffe (Giraffa camelopardalis). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20091201
Evaluation of two short-term anesthetic protocols in captive juvenile pronghorn (Antilocapra americana). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20091201
Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane. Journal of the South African Veterinary Association 20091201
Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20091101
[11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20091101
Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive care medicine 20091101
Defeating normal thermoregulatory defenses: induction of therapeutic hypothermia. Stroke 20091101
Dexmedetomidine pharmacokinetics in pediatric intensive care--a pooled analysis. Paediatric anaesthesia 20091101
Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units. Intensive care medicine 20091101
'Above all, do no harm': hippocrates. Anesthesiology 20091101
Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). Anesthesiology 20091101
Comparison between dexmedetomidine and remifentanil for intraoperative controlled hypotension. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20091101
Atipamezole changes the antinociceptive effects of butorphanol after medetomidine-ketamine anaesthesia in rats. Veterinary anaesthesia and analgesia 20091101
Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat. Anesthesiology 20091101
Dexmedetomidine as sole sedative during percutaneous carotid artery stenting in a patient with severe chronic obstructive pulmonary disease. Minerva anestesiologica 20091101
Traumatic brain injury: neuroprotective anaesthetic techniques, an update. Injury 20091101
[Perioperative management of a patient with myasthenia gravis using dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20091101
Profound reduction in sedation and analgesic requirements using extended dexmedetomidine infusions in a patient with an open abdomen. Military medicine 20091101
Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children. Journal of clinical anesthesia 20091101
Alpha-2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery. The Cochrane database of systematic reviews 20091007
Benzodiazepines for delirium. The Cochrane database of systematic reviews 20091007
Evaluation of cardiorespiratory effects of combinations of dexmedetomidine and atropine in cats. Journal of feline medicine and surgery 20091001
Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogs. Documenta ophthalmologica. Advances in ophthalmology 20091001
The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta anaesthesiologica Scandinavica 20091001
The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease. European journal of anaesthesiology 20091001
Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration. Journal of feline medicine and surgery 20091001
Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. The Journal of pharmacology and experimental therapeutics 20091001
Local anaesthetic adjuvants: neuraxial versus peripheral nerve block. Current opinion in anaesthesiology 20091001
Sedation and regional anesthesia. Current opinion in anaesthesiology 20091001
Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats. Resuscitation 20091001
Cardiovascular reflex responses to temporal reduction in arterial pressure during dexmedetomidine infusion: a double-blind, randomized, and placebo-controlled study. British journal of anaesthesia 20091001
Dexmedetomidine for awake fiberoptic intubation in a parturient with spinal muscular atrophy type III for cesarean delivery. International journal of obstetric anesthesia 20091001
Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss. Genes, brain, and behavior 20091001
Re: Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. British journal of anaesthesia 20091001
Antinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious cats. Journal of veterinary pharmacology and therapeutics 20091001
Successful use of dexmedetomidine for sedation in a 24-week gestational age neonate. The Annals of pharmacotherapy 20091001
A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection. PLoS pathogens 20091001
Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20091001
Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist. Brain research 20090929
Prolonged dexmedetomidine infusions in critically ill infants and children. Indian pediatrics 20090901
Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury. Acta anaesthesiologica Scandinavica 20090901
Dexmedetomidine and proprofol in complex microlaryngeal surgery in infants. International journal of pediatric otorhinolaryngology 20090901
Evaluation of the muscular relaxant effect of dexmedetomidine or medetomidine in cats. Veterinary research communications 20090901
Perioperative use of dexmedetomidine in an infant with familial dysautonomia. British journal of anaesthesia 20090901
Dexmedetomidine chemical restraint of two raptor species undergoing inhalation anaesthesia. Veterinary research communications 20090901
The normal electroretinogram in adult healthy Shih Tzu dogs using the HMsERG. Journal of veterinary science 20090901
Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. The Annals of pharmacotherapy 20090901
A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesthesia and analgesia 20090901
Sedation and drugs in pediatric patients: what is new? Paediatric anaesthesia 20090901
New caudal additives in children: benefit vs. risk? Acta anaesthesiologica Scandinavica 20090901
A study of cardiovascular function under controlled and spontaneous ventilation in isoflurane-medetomidine anaesthetized horses. Veterinary anaesthesia and analgesia 20090901
A recruitment breath manoeuvre directly after endotracheal suction improves lung function: an experimental study in pigs. Upsala journal of medical sciences 20090901
Update on dexmedetomidine for adult ICU sedation. Connecticut medicine 20090901
Sedation challenges in the pediatric ICU: is dexmedetomidine the solution? Indian pediatrics 20090901
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. Journal of clinical anesthesia 20090901
Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension. Journal of clinical anesthesia 20090901
Dexmedetomidine supplemented with local anesthesia for awake laryngoplasty. Journal of clinical anesthesia 20090901
Dexmedetomidine used to provide hypotensive anesthesia during middle ear surgery. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20090901
The influences of propofol and dexmedetomidine on circadian gene expression in rat brain. Brain research bulletin 20090814
Effects of sedative and hypnotic drug combinations on transcranial magnetic motor evoked potential, bispectral index and ARX-derived auditory evoked potential index in dogs. Veterinary journal (London, England : 1997) 20090801
Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cerebral cortex (New York, N.Y. : 1991) 20090801
The effect of the novel partial alpha2-adrenoceptor agonist naphthylmedetomidine on the basic cardiorespiratory parameters and behavior in rhesus monkeys. Journal of medical primatology 20090801
Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis. Pharmacology & therapeutics 20090801
Risk and safety of pediatric sedation/anesthesia for procedures outside the operating room. Current opinion in anaesthesiology 20090801
Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. British journal of anaesthesia 20090801
Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current. British journal of anaesthesia 20090801
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. Pediatric neurology 20090801
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. Anesthesia and analgesia 20090801
Using a thoracic epidural catheter in a high-risk pediatric transplant patient. The Annals of thoracic surgery 20090801
[Effect of dexmedetomidine on intraoperative somatosensory evoked potential monitoring]. Masui. The Japanese journal of anesthesiology 20090801
[Cardiac arrest induced by dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20090801
[Anesthetic management in a case of myotonic distrophy with dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20090801
Dexmedetomidine use in general anaesthesia. Current drug targets 20090801
New drugs for epidural analgesia. Current drug targets 20090801
Isolation of tumour stem-like cells from benign tumours. British journal of cancer 20090721
A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity. NeuroImage 20090715
Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine. International journal of obstetric anesthesia 20090701
Intravenous dexmedetomidine as an adjunct for labor analgesia and cesarean delivery anesthesia in a parturient with a tethered spinal cord. International journal of obstetric anesthesia 20090701
Isoflurane attenuates pulmonary interleukin-1beta and systemic tumor necrosis factor-alpha following mechanical ventilation in healthy mice. Acta anaesthesiologica Scandinavica 20090701
Bioaccumulation of the new antifoulant medetomidine in marine organisms. Marine environmental research 20090701
Intravenous dexmedetomidine for obstetric anaesthesia and analgesia: converting a challenge into an opportunity? International journal of obstetric anesthesia 20090701
A comparison of the efficacy and cardiorespiratory effects of four medetomidine-based anaesthetic protocols in the red fox (Vulpes vulpes). Veterinary anaesthesia and analgesia 20090701
Evaluation of the anaesthetic effects of medetomidine and ketamine in rats and their reversal with atipamezole. Veterinary anaesthesia and analgesia 20090701
Clinical evaluation of the efficacy and safety of a constant rate infusion of dexmedetomidine for postoperative pain management in dogs. Veterinary anaesthesia and analgesia 20090701
Suppression of shivering during hypothermia using a novel drug combination in healthy volunteers. Anesthesiology 20090701
A comparison of the effects on respiratory carbon dioxide response, arterial blood pressure, and heart rate of dexmedetomidine, propofol, and midazolam in sevoflurane-anesthetized rabbits. Anesthesia and analgesia 20090701
Thermoregulatory defense mechanisms. Critical care medicine 20090701
Incorrect comments regarding the use of butorphanol-medetomidine as a premedicant in cats. The Journal of small animal practice 20090701
Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. Critical care clinics 20090701
Altering intensive care sedation paradigms to improve patient outcomes. Critical care clinics 20090701
Sedation & immunomodulation. Critical care clinics 20090701
Reversible immobilization of free-ranging Svalbard reindeer (Rangifer tarandus platyrhynchus) with medetomidine-ketamine and atipamezole. Journal of wildlife diseases 20090701
The effects of dexmedetomidine and fentanyl on emergence characteristics after adenoidectomy in children. Anaesthesia and intensive care 20090701
Diuretic effects of medetomidine compared with xylazine in healthy dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20090701
Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. Neuroscience letters 20090626
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA 20090617
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA 20090617
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA 20090617
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA 20090617
Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages. The Journal of surgical research 20090615
Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy. Journal of veterinary science 20090601
Evaluation of the effects of naloxone on recovery time and quality after ketamine-medetomidine-butorphanol anesthesia in servals (Leptailurus serval). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20090601
The effects of different anesthetic agents on short electroretinography protocol in dogs. The Journal of veterinary medical science 20090601
Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia. Middle East journal of anaesthesiology 20090601
Sedating the child with congenital heart disease. Anesthesiology clinics 20090601
Clonidine in paediatrics - a review. Indian journal of anaesthesia 20090601
Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation. Veterinary journal (London, England : 1997) 20090501
Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery. Minerva anestesiologica 20090501
The use of dexmedetomidine in critically ill children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090501
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 20090501
Postoperative intensive care unit drug fever caused by dexmedetomidine. Anesthesia and analgesia 20090501
Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy. Australian veterinary journal 20090501
Influence of anesthetic management on quality of magnetoencephalography scan data in pediatric patients: a case series. Paediatric anaesthesia 20090501
Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation. Journal of clinical anesthesia 20090501
Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia: case report and literature review. Journal of clinical anesthesia 20090501
Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL/6J and mixed genetic backgrounds. Journal of the American Association for Laboratory Animal Science : JAALAS 20090501
Dexmedetomidine blunts haemodynamic and intraocular pressure responses to tracheal intubation. European journal of anaesthesiology 20090501
Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis. World journal of gastroenterology 20090407
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. Brain research 20090406
Direct effect of dexmedetomidine on rat isolated aorta involves endothelial nitric oxide synthesis and activation of the lipoxygenase pathway. Clinical and experimental pharmacology & physiology 20090401
Severe rash associated with dexmedetomidine use during mechanical ventilation. Pharmacotherapy 20090401
Alpha2-adrenergic agonists and their role in the prevention of perioperative adverse cardiac events. AANA journal 20090401
Butorphanol-azaperone-medetomidine for immobilization of captive white-tailed deer. Journal of wildlife diseases 20090401
Butorphanol, azaperone, and medetomidine anesthesia in free-ranging white-tailed deer (Odocoileus virginianus) using radiotransmitter darts. Journal of wildlife diseases 20090401
An endoscopic method for identifying sex of hatchling Chinese box turtles and comparison of general versus local anesthesia for coelioscopy. Journal of the American Veterinary Medical Association 20090315
Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20090301
Role of alpha2-adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats. The Journal of urology 20090301
Dexmedetomidine sedation for pediatric post-Fontan procedure patients. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090301
Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord. Anesthesiology 20090301
An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine. Anesthesia and analgesia 20090301
The use of lingual venous blood to determine the acid-base and blood-gas status of dogs under anesthesia. Veterinary anaesthesia and analgesia 20090301
The effect of the novel alpha-2-adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits. Veterinary anaesthesia and analgesia 20090301
Effects of medetomidine, L-methadone, and their combination on arterial blood gases in dogs. Veterinary anaesthesia and analgesia 20090301
Effect of dexmedetomidine added to spinal bupivacaine for urological procedures. Saudi medical journal 20090301
[Anesthesia induction for patients with cervical spinal disease]. Masui. The Japanese journal of anesthesiology 20090301
Activated toxicity of diesel particulate extract by ultraviolet a radiation in mammalian cells: role of singlet oxygen. Environmental health perspectives 20090301
Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control. Journal of medical and dental sciences 20090301
Effects of the noradrenergic system in rat white matter exposed to oxygen-glucose deprivation in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090211
A new era for sedation in ICU patients. JAMA 20090204
Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 20090204
Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive care medicine 20090201
Does pethidine affect the cardiovascular and sedative effects of dexmedetomidine in dogs? The Journal of small animal practice 20090201
Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics. Acta anaesthesiologica Scandinavica 20090201
Dexmedetomidine anaesthesia for patients with obstructive sleep apnoea undergoing bariatric surgery. European journal of anaesthesiology 20090201
Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit. Cardiology in the young 20090201
Propofol and midazolam inhibit conscious memory processes very soon after encoding: an event-related potential study of familiarity and recollection in volunteers. Anesthesiology 20090201
Investigating medetomidine-buprenorphine as preanaesthetic medication in cats. The Journal of small animal practice 20090201
[Planned sedation with dexmedetomidine hydrochloride after pediatric cardiac surgery; an institutional experience]. Kyobu geka. The Japanese journal of thoracic surgery 20090201
Determination of the pharmacodynamic interaction of propofol and dexmedetomidine during esophagogastroduodenoscopy in children. Paediatric anaesthesia 20090201
Hypoglycemia associated with dexmedetomidine overdose in a child? Journal of clinical anesthesia 20090201
Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia. Biomedical research (Tokyo, Japan) 20090201
Remifentanil-propofol vs dexmedetomidine-propofol--anesthesia for supratentorial craniotomy. Middle East journal of anaesthesiology 20090201
Expression of Mipu1 in response to myocardial infarction in rats. International journal of molecular sciences 20090201
Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses. Equine veterinary journal 20090201
Induction of anaesthesia in wild rabbits using a new alfaxalone formulation. The Veterinary record 20090124
Benzodiazepines for delirium. The Cochrane database of systematic reviews 20090121
Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo. The Journal of comparative neurology 20090110
The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage. Surgical neurology 20090101
Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. British journal of anaesthesia 20090101
Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. British journal of anaesthesia 20090101
Intraperitoneal anaesthesia with propofol, medetomidine and fentanyl in mice. Laboratory animals 20090101
Propofol-sparing or lipid-sparing? Paediatric anaesthesia 20090101
Dexmedetomidine sedation (and cardiac perforation, pericardial tamponade, cardiac arrest, and cardiopulmonary resuscitation) leading to refractory cardiogenic shock. Anesthesia and analgesia 20090101
Caution is necessary when dexmedetomidine is used off-label, especially when combined with other sedatives. Anesthesia and analgesia 20090101
Dexmedetomidine and refractory cardiogenic shock. Anesthesia and analgesia 20090101
Effect of bupivacaine on epidural analgesia produced by xylazine or medetomidine in buffaloes (Bubalus bubalis). Veterinary anaesthesia and analgesia 20090101
Intravenous dexmedetomidine infusion for labour analgesia in patient with preeclampsia. European journal of anaesthesiology 20090101
Addition of dexmedetomidine or lornoxicam to prilocaine in intravenous regional anaesthesia for hand or forearm surgery: a randomized controlled study. Clinical drug investigation 20090101
Dexmedetomidine as a substitute for remifentanil in ambulatory gynecologic laparoscopic surgery. Saudi medical journal 20090101
Host-derived smooth muscle cells accumulate in cardiac allografts: role of inflammation and monocyte chemoattractant protein 1. PloS one 20090101
Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: a histopathologic study. Renal failure 20090101
HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS medicine 20090101
Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. Critical care (London, England) 20090101
[Anesthetic management using epidural anesthesia and dexmedetomidine for thoracoscopic lung resection in a patient with compromised lung functions]. Masui. The Japanese journal of anesthesiology 20090101
[Management of anesthesia with artificial pancreas STG-22 for pheochromocytoma resection]. Masui. The Japanese journal of anesthesiology 20090101
Central sympatholytics prolong survival in experimental sepsis. Critical care (London, England) 20090101
Awake thyroidectomy under local anesthesia and dexmedetomidine infusion. Military medicine 20090101
The RPGRIP1-deficient dog, a promising canine model for gene therapy. Molecular vision 20090101
Critical Care Canada Forum 2008, 11-13 November 2008, Toronto, Ontario, Canada. Critical care (London, England) 20090101
Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study. Critical care (London, England) 20090101
Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy. Journal of anesthesia 20090101
Dexmedetomidine facilitates induction of noninvasive positive pressure ventilation for acute respiratory failure in patients with severe asthma. Journal of anesthesia 20090101
Evaluation of single-stage adjustable strabismus surgery under conscious sedation. Indian journal of ophthalmology 20090101
Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. Journal of biomedical science 20090101
cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis. PloS one 20090101
Research and development of a new RF-assisted device for bloodless rapid transection of the liver: computational modeling and in vivo experiments. Biomedical engineering online 20090101
Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Molecular systems biology 20090101
Treating agitation with dexmedetomidine in the ICU. Dimensions of critical care nursing : DCCN 20090101
Evaluation of dog owners' perceptions concerning radiation therapy. Acta veterinaria Scandinavica 20090101
Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse. Acta veterinaria Scandinavica 20090101
Neuroimmune perspectives in sepsis. Critical care (London, England) 20090101
BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil. Critical care (London, England) 20090101
Opioid-free balanced anesthesia for cervical ganglionectomy subsequent to recent ultra rapid opioid detoxification. Pain medicine (Malden, Mass.) 20090101
Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Critical care (London, England) 20090101
Does pilocarpine-induced epilepsy in adult rats require status epilepticus? PloS one 20090101
Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery. Journal of burn care & research : official publication of the American Burn Association 20090101
Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 20090101
Tackling agitated delirium--the tip of the iceberg. Critical care (London, England) 20090101
Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits. Polish journal of veterinary sciences 20090101
Dexmedetomidine as a novel therapeutic for postoperative pain in a patient treated with buprenorphine. Journal of opioid management 20090101
Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task. Journal of biomedical science 20090101
Dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic brain injury in rats. Journal of anesthesia 20090101
Sedation improves early outcome in severely septic Sprague Dawley rats. Critical care (London, England) 20090101
Dexmedetomidine sedation for carotid endarterectomy. Anestezjologia intensywna terapia 20090101
Evaluation of the potential for interaction between a metaflumizone-amitraz combination and dexmedetomidine hydrochloride in dogs. Veterinary therapeutics : research in applied veterinary medicine 20090101
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PloS one 20090101
Cortical Membrane Potential Dynamics and Laminar Firing during Object Motion. Frontiers in systems neuroscience 20090101
Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium. PloS one 20090101
Psychosedation with dexmedetomidine hydrochloride during minor oral surgery. Anesthesia progress 20090101
Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis research & therapy 20090101
Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions. Radiation oncology (London, England) 20090101
Immunosedation: a consideration for sepsis. Critical care (London, England) 20090101
Protocol for the 'Michigan Awareness Control Study': A prospective, randomized, controlled trial comparing electronic alerts based on bispectral index monitoring or minimum alveolar concentration for the prevention of intraoperative awareness. BMC anesthesiology 20090101
Effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in rats. Regional anesthesia and pain medicine 20090101
Establishment, immortalisation and characterisation of pteropid bat cell lines. PloS one 20090101
The incidence of sub-optimal sedation in the ICU: a systematic review. Critical care (London, England) 20090101
Anesthetic management for cesarean delivery in a pregnant woman with polymyositis: A case report and review of literature. Cases journal 20090101
Sevoflurane-emergence agitation: Effect of supplementary low-dose oral ketamine premedication in preschool children undergoing dental surgery. Saudi journal of anaesthesia 20090101
Omentalisation as adjunctive treatment of an infected femoral nonunion fracture: a case report. Irish veterinary journal 20090101
Analgesic management of an eight-year-old Springer Spaniel after amputation of a thoracic limb. Irish veterinary journal 20090101
Investigation of modulation of the alpha-2 receptor in tetrahydropalmatine (THP) analgesia in male Sprague-Dawley rats. Journal of dietary supplements 20090101
In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action. European journal of pharmacology 20081203
Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy. European journal of anaesthesiology 20081201
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. British journal of pharmacology 20081201
Anesthesia for outpatient cosmetic surgery. Current opinion in anaesthesiology 20081201
A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesthesia and analgesia 20081201
Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery. Anesthesia and analgesia 20081201
Anaesthesia recovery quality after racemic ketamine or S-ketamine administration to male cats undergoing neutering surgery. Schweizer Archiv fur Tierheilkunde 20081201
Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses. Emerging infectious diseases 20081201
Effects of dexmedetomidine on propofol and remifentanil infusion rates during total intravenous anesthesia for spine surgery in adolescents. Paediatric anaesthesia 20081201
Dexmedetomidine: more than a sedative and analgesic. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20081201
Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20081201
Determination of a sedative protocol for use in California sea lions (Zalophus californianus) with neurologic abnormalities undergoing electroencephalographic examination. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201
Field anesthesia of golden jackals (Canis aureus) with the use of medetomidine-ketamine or medetomidine-midazolam with atipamezole reversal. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201
Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs. Veterinary anaesthesia and analgesia 20081101
Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents. Paediatric anaesthesia 20081101
Dexmedetomidine infusion as adjunctive therapy to benzodiazepines for acute alcohol withdrawal. The Annals of pharmacotherapy 20081101
Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery. European journal of anaesthesiology 20081101
Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20081101
Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study. Anesthesia and analgesia 20081101
Induced hypotension in orthognathic surgery: a comparative study of 2 pharmacological protocols. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20081101
Adjunctive analgesic therapy in veterinary medicine. The Veterinary clinics of North America. Small animal practice 20081101
Effects of premedication with tiletamine/zolazepam/medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation. Transplantation proceedings 20081101
[Pulmonary aspiration during anesthetic induction in a patient with a history of distal gastrectomy]. Masui. The Japanese journal of anesthesiology 20081101
Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of Guinea pigs. Journal of the American Association for Laboratory Animal Science : JAALAS 20081101
Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery. European journal of anaesthesiology 20081001
Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. British journal of pharmacology 20081001
Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress. Neuropharmacology 20081001
Anesthesia for functional neurosurgery: the role of dexmedetomidine. Current opinion in anaesthesiology 20081001
The effect of dexmedetomidine on perioperative hemodynamics in patients undergoing craniotomy. Anesthesia and analgesia 20081001
Electrocardiographic changes in rats undergoing thoracic surgery under combined parenteral anesthesia. Lab animal 20081001
Anesthetic management of adenotonsillectomy in a child with bidirectional superior cavapulmonary shunt. Paediatric anaesthesia 20081001
A combination of ketamine and dexmedetomidine sedation with caudal anesthesia during incarcerated inguinal hernia repair in three high-risk infants. Paediatric anaesthesia 20081001
Dexmedetomidine and ketamine for large anterior mediastinal mass biopsy. Paediatric anaesthesia 20081001
Dexmedetomidine weakens dynamic cerebral autoregulation as assessed by transfer function analysis and the thigh cuff method. Anesthesiology 20081001
Evaluation of the efficacy and safety for use of two sedation and analgesia protocols to facilitate assisted ventilation of healthy dogs. American journal of veterinary research 20081001
Future directions in endoscopic sedation. Gastrointestinal endoscopy clinics of North America 20081001
Dexmedetomidine: a useful adjunct to consider in some high-risk situations. AANA journal 20081001
Immobilization of free-ranging Hoffmann's two-toed and brown-throated three-toed sloths using ketamine and medetomidine: a comparison of physiologic parameters. Journal of wildlife diseases 20081001
Evaluation of analgesic and sedative effects of continuous infusion of dexmedetomidine by measuring somatosensory- and auditory-evoked potentials in the rat. Veterinary anaesthesia and analgesia 20080901
The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs. Veterinary anaesthesia and analgesia 20080901
The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide. Veterinary anaesthesia and analgesia 20080901
Sedation during ophthalmic surgery. European journal of anaesthesiology 20080901
Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery. British journal of anaesthesia 20080901
alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. American journal of physiology. Renal physiology 20080901
Motor and somatosensory evoked potentials are well maintained in patients given dexmedetomidine during spine surgery. Anesthesiology 20080901
Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anesthesiology 20080901
Dexmedetomidine-based versus fentanyl-based total intravenous anesthesia for lumbar laminectomy. Minerva anestesiologica 20080901
Evaluation of intramuscular butorphanol, azaperone, and medetomidine and nasal oxygen insufflation for the chemical immobilization of white-tailed deer, Odocoileus virginianus. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080901
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses. Evidence-based complementary and alternative medicine : eCAM 20080901
Dexmedetomidine sedation for laryngeal framework surgery. The Annals of otology, rhinology, and laryngology 20080901
Antimicrobial effects of two anaesthetic agents: dexmedetomidine and midazolam. Anaesthesia and intensive care 20080901
The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters. Journal of clinical anesthesia 20080901
Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations. Journal of clinical anesthesia 20080901
Dexmedetomidine and ketamine for fiberoptic intubation in a child with severe mandibular hypoplasia. Journal of clinical anesthesia 20080901
Thermal, cardiorespiratory and cortisol responses of impala (Aepyceros melampus) to chemical immobilisation with 4 different drug combinations. Journal of the South African Veterinary Association 20080901
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Current neuropharmacology 20080901
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans. Current neuropharmacology 20080901
Comparison of dexmedetomidine-propofol vs. fentanyl-propofol for laryngeal mask insertion. European journal of anaesthesiology 20080801
Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20080801
Novel use of dexmedetomidine in a patient with pulmonary hypertension. Paediatric anaesthesia 20080801
Dexmedetomidine disposition in children: a population analysis. Paediatric anaesthesia 20080801
The pharmacology of oversedation in mechanically ventilated adults. Current opinion in critical care 20080801
Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesthesia and analgesia 20080801
Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats. Anesthesia and analgesia 20080801
Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits. Journal of veterinary pharmacology and therapeutics 20080801
Dexmedetomidine: a review of clinical applications. Current opinion in anaesthesiology 20080801
Pediatric sedation/anesthesia outside the operating room. Current opinion in anaesthesiology 20080801
Dexmedetomidine sedation in a patient with superior vena cava syndrome and extreme needle phobia. Journal of cardiothoracic and vascular anesthesia 20080801
[Dexmedetomidine for sedation during voice monitoring surgery in a patient with an episode of seizure]. Masui. The Japanese journal of anesthesiology 20080801
The effects of dexmedetomidine on human neutrophil apoptosis. Biomedical research (Tokyo, Japan) 20080801
Dexmedetomidine for sedation during electroencephalographic analysis in children with autism, pervasive developmental disorders, and seizure disorders. Journal of clinical anesthesia 20080801
Effects of subchronic versus acute in utero exposure to dexmedetomidine on foetal developments in rats. Basic & clinical pharmacology & toxicology 20080801
Dexmedetomidine and arousal affect subthalamic neurons. Movement disorders : official journal of the Movement Disorder Society 20080715
The influence of dexmedetomidine on ischemic rat hippocampus. Brain research 20080707
Severe hypertension and bradycardia after dexmedetomidine for radiology sedation in a patient with acute transverse myelitis. Paediatric anaesthesia 20080701
Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells. Journal of neurochemistry 20080701
Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy. Journal of neurosurgical anesthesiology 20080701
High dose of dexmedetomidine was useful for general anesthesia and post-operative analgesia in a patient with postpolio syndrome. Acta anaesthesiologica Scandinavica 20080701
Intubation of an infant with Pierre Robin sequence under dexmedetomidine sedation using the Shikani Optical Stylet. Acta anaesthesiologica Scandinavica 20080701
Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor. Anesthesia and analgesia 20080701
The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study. Anesthesia and analgesia 20080701
Immobilization of black bears (Ursus americanus) with a combination of butorphanol, azaperone, and medetomidine. Journal of wildlife diseases 20080701
Effects of medetomidine and midazolam alone or in combination on the metabolic and neurohormonal responses in healthy cats. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080701
Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs. The Veterinary record 20080628
Sedation with dexmedetomidine for vocal fold injection. The New Zealand medical journal 20080606
A comparison of esmolol and dexmedetomidine for attenuation of intraocular pressure and haemodynamic responses to laryngoscopy and tracheal intubation. European journal of anaesthesiology 20080601
Cost of dexmedetomidine in MRI. Paediatric anaesthesia 20080601
Management of accidental spinal administration of extended-release epidural morphine. Anesthesiology 20080601
Expecting the unexpected. Anesthesia and analgesia 20080601
A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. Anesthesia and analgesia 20080601
Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables. Anesthesia and analgesia 20080601
The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat. Anesthesia and analgesia 20080601
Dexmedetomidine sedation leading to refractory cardiogenic shock. Anesthesia and analgesia 20080601
Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs. American journal of veterinary research 20080601
[Postoperative management of carotid endarterectomy with dexmedetomidine--a comparison with propofol]. Masui. The Japanese journal of anesthesiology 20080601
[Dexmedetomidine infusion for sedation during awake intubation]. Masui. The Japanese journal of anesthesiology 20080601
[Ambulatory anesthesia for an adult patient with autism and epilepsy: sedation using oral and intravenous dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20080601
The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. Journal of medical primatology 20080601
Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord. The European journal of neuroscience 20080601
The use of continuous positive airway pressure during an awake craniotomy in a patient with obstructive sleep apnea. Journal of clinical anesthesia 20080601
Caesarian section and neonatal care in the aardvark (Orycteropus afer). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080601
Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clinical pharmacology and therapeutics 20080501
Pharmaceutical particle engineering via spray drying. Pharmaceutical research 20080501
The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route. European journal of anaesthesiology 20080501
Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy. European journal of anaesthesiology 20080501
Comparison between dexmedetomidine and remifentanil for controlled hypotension during tympanoplasty. European journal of anaesthesiology 20080501
Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. British journal of pharmacology 20080501
Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain. The journal of gene medicine 20080501
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors. Neuropharmacology 20080501
High dose dexmedetomidine as the sole sedative for pediatric MRI. Paediatric anaesthesia 20080501
Hemodynamic effects of dexmedetomidine sedation for CT imaging studies. Paediatric anaesthesia 20080501
Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age. British journal of anaesthesia 20080501
The central hypotensive effect induced by alpha 2-adrenergic receptor stimulation is dependent on endothelial nitric oxide synthase. Journal of hypertension 20080501
Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone. American journal of veterinary research 20080501
Dexmedetomidine: sedation, analgesia and beyond. Expert opinion on drug metabolism & toxicology 20080501
Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia. Expert opinion on drug metabolism & toxicology 20080501
Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience 20080409
Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA 20080402
Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA 20080402
Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA 20080402
Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events. Cardiovascular drugs and therapy 20080401
Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation. British journal of anaesthesia 20080401
Clinical efficacy of dexmedetomidine alone is less than propofol for conscious sedation during ERCP. Gastrointestinal endoscopy 20080401
Thermal antinociception after dexmedetomidine administration in cats: a dose-finding study. Journal of veterinary pharmacology and therapeutics 20080401
Transmucosal dexmedetomidine for computed tomography sedation. Paediatric anaesthesia 20080401
Postoperative management of cleft lip repair using dexmedetomidine in a child with bidirectional superior cavopulmonary shunt. Paediatric anaesthesia 20080401
[Use of high-dose dexmedetomidine infusion for anesthesia and sedation in a patient for microlaryngeal surgery maintained with spontaneous breathing]. Masui. The Japanese journal of anesthesiology 20080401
Improving outcomes in pediatric procedural sedation. Joint Commission journal on quality and patient safety 20080401
Neurohormonal and metabolic effects of medetomidine compared with xylazine in healthy cats. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080401
Comparison of meperidine alone with meperidine plus dexmedetomidine for postoperative patient-controlled analgesia. Neurosciences (Riyadh, Saudi Arabia) 20080401
Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain. European journal of pharmacology 20080317
Quality and in vitro fertilizing ability of cryopreserved cat spermatozoa obtained by urethral catheterization after medetomidine administration. Theriogenology 20080301
Dexmedetomidine constant rate infusion for 24 hours during and after propofol or isoflurane anaesthesia in dogs. Veterinary anaesthesia and analgesia 20080301
A comparison of ketamine-midazolam and ketamine-medetomidine combinations for induction of anaesthesia in rabbits. Veterinary anaesthesia and analgesia 20080301
Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology 20080301
Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves. American journal of veterinary research 20080301
Sedation in the neurologic intensive care unit. Current treatment options in neurology 20080301
Use of dexmedetomidine for sedation of children hospitalized in the intensive care unit. Journal of hospital medicine 20080301
Development of a canine nociceptive thermal escape model. Journal of neuroscience methods 20080215
Effect of medetomidine infusion on the anaesthetic requirements of desflurane in dogs. Research in veterinary science 20080201
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats. Journal of feline medicine and surgery 20080201
Effects of medetomidine on Doppler variables of major abdominal arteries in normal dogs. Veterinary research communications 20080201
Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration. Acta anaesthesiologica Scandinavica 20080201
Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta anaesthesiologica Scandinavica 20080201
Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension (Dallas, Tex. : 1979) 20080201
Comparative effects of propofol vs dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock. British journal of anaesthesia 20080201
Intravenous anesthesia for thoracic procedures. Current opinion in anaesthesiology 20080201
Feasibility of dexmedetomidine in facilitating extubation in the intensive care unit. Journal of clinical pharmacy and therapeutics 20080201
Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans. Anesthesiology 20080201
Pro: dexmedetomidine should be used for infants and children undergoing cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20080201
Con: dexmedetomidine should not be used for infants and children during cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20080201
Reversible medetomidine/ketamine anesthesia in captive capuchin monkeys (Cebus apella). Journal of medical primatology 20080201
[Ultra fast-track anesthesia with operating room extubation in a patient undergoing OPCABG by combination of propofol-remifentanil-dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20080201
Successful intraoperative spinal cord monitoring during scoliosis surgery using a total intravenous anesthetic regimen including dexmedetomidine. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20080201
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. AANA journal 20080201
Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. The Veterinary record 20080119
The effects of medetomidine on radial nerve blockade with mepivacaine in dogs. Veterinary anaesthesia and analgesia 20080101
Effects of medetomidine on hepatic EROD activity in three species of fish. Ecotoxicology and environmental safety 20080101
Effects of dexmedetomidine infusion in patients undergoing functional endoscopic sinus surgery under local anaesthesia. European journal of anaesthesiology 20080101
Anatomical and experimental studies of brachial plexus, sciatic, and femoral nerve-location using peripheral nerve stimulation in the dog. Veterinary anaesthesia and analgesia 20080101
Inhibitory effects of the alpha-2 adrenergic agonists clonidine and dexmedetomidine on enhanced airway tone in ovalbumin-sensitized guinea pigs. European journal of anaesthesiology 20080101
BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat. NeuroImage 20080101
Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic & clinical pharmacology & toxicology 20080101
Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia 20080101
Acute discontinuation syndrome from dexmedetomidine after protracted use in a pediatric patient. Paediatric anaesthesia 20080101
Use of dexmedetomidine in the pediatric intensive care unit. Pharmacotherapy 20080101
Dexmedetomidine reduces long-term potentiation in mouse hippocampus. Anesthesiology 20080101
Perioperative events during deep brain stimulation: the experience at cleveland clinic. Journal of neurosurgical anesthesiology 20080101
Clinical uses of dexmedetomidine in pediatric patients. Paediatric drugs 20080101
The effects of dexmedetomidine on cardiac electrophysiology in children. Anesthesia and analgesia 20080101
A comparison of sedation with dexmedetomidine or propofol during shockwave lithotripsy: a randomized controlled trial. Anesthesia and analgesia 20080101
Dexmedetomidine in aesthetic facial surgery: improving anesthetic safety and efficacy. Plastic and reconstructive surgery 20080101
Dexmedetomidine continuous rate infusion during isoflurane anaesthesia in canine surgical patients. Veterinary anaesthesia and analgesia 20080101
Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization. American journal of therapeutics 20080101
Capture and medetomidine-ketamine anesthesia of free-ranging wolverines (Gulo gulo). Journal of wildlife diseases 20080101
[Clinical evaluation of three medetomidine--midazolam--ketamine combinations for neutering of ferrets (Mustela putorius furo)]. Berliner und Munchener tierarztliche Wochenschrift 20080101
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis research & therapy 20080101
Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision. Molecular pain 20080101
Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice. Aggressive behavior 20080101
Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs. Laboratory animals 20080101
Precedex: is it the future of cooperative sedation? Nursing 20080101
Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia. PloS one 20080101
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. PloS one 20080101
[Drug therapy of opioid withdrawal]. Vertex (Buenos Aires, Argentina) 20080101
Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation. European journal of ophthalmology 20080101
Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo. BMC biotechnology 20080101
High-dose dexmedetomidine-induced hypertension in a child with traumatic brain injury. Neurocritical care 20080101
Delirium in the intensive care unit. Critical care (London, England) 20080101
Medications for analgesia and sedation in the intensive care unit: an overview. Critical care (London, England) 20080101
Strategies to optimize analgesia and sedation. Critical care (London, England) 20080101
[Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia]. Revista da Associacao Medica Brasileira (1992) 20080101
Dexmedetomidine use in critical care. AACN advanced critical care 20080101
Management of anesthesia in awake craniotomy. Minerva anestesiologica 20080101
Non-linear population firing rates and voltage sensitive dye signals in visual areas 17 and 18 to short duration stimuli. PloS one 20080101
Dexmedetomidine reduces the ischemia-reperfusion injury markers during upper extremity surgery with tourniquet. The Journal of hand surgery 20080101
Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. Journal of anesthesia 20080101
Analgesic effect of dexmedetomidine in a patient with herpetic stomatitis after living-donor lung transplantation. Journal of anesthesia 20080101
Sedation of hypercyanotic spells in a neonate with tetralogy of Fallot using dexmedetomidine. Jornal de pediatria 20080101
Dexmedetomidine in anesthesia of children submitted to videolaparoscopic appendectomy: a double-blind, randomized and placebo-controlled study. Revista da Associacao Medica Brasileira (1992) 20080101
Functional MRI of auditory responses in the zebra finch forebrain reveals a hierarchical organisation based on signal strength but not selectivity. PloS one 20080101
Intravenous sedation with low-dose dexmedetomidine: its potential for use in dentistry. Anesthesia progress 20080101
Allogeneic and autogenous transplantations of MSCs in treatment of the physeal bone bridge in rabbits. BMC biotechnology 20080101
Bradycardia during dexmedetomidine and therapeutic hypothermia. Journal of intensive care medicine 20080101
Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension. BMC neuroscience 20080101
Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. BMC pharmacology 20080101
Subcutaneous dexmedetomidine infusions to treat or prevent drug withdrawal in infants and children. Journal of opioid management 20080101
Frontal EEG for intensive care unit sedation: treating numbers or patients? Critical care (London, England) 20080101
Single dose of morphine produced a prolonged effect on dopamine neuron activities. Molecular pain 20080101
The effects of medetomidine hydrochloride on the electroretinogram of normal dogs. Veterinary ophthalmology 20080101
Sedation practice in the intensive care unit: a UK national survey. Critical care (London, England) 20080101
Intraperitoneal implantation of life-long telemetry transmitters in otariids. BMC veterinary research 20080101
Preliminary experience with dexmedetomidine for monitored anesthesia care during ENT surgical procedures. American journal of therapeutics 20080101
Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs. Journal of investigative surgery : the official journal of the Academy of Surgical Research 20080101
Blind nasotracheal intubation in awaken patient scheduled for hemimandibulectomy. Case report. Revista brasileira de anestesiologia 20080101
[Perioperative risk in patients with sleep apnoea]. Anestezjologia intensywna terapia 20080101
Anaesthesia for the geriatric dog and cat. Irish veterinary journal 20080101
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 20071212
TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics. The Journal of pharmacology and experimental therapeutics 20071201
The analgesic effect of inhalational Entonox for extracorporeal shock wave lithotripsy. Urological research 20071201
The use of dexmedetomidine during laryngoscopy, bronchoscopy, and tracheal extubation following tracheal reconstruction. Paediatric anaesthesia 20071201
The anesthetic effects of etomidate: species-specific interaction with alpha 2-adrenoceptors. Anesthesia and analgesia 20071201
The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats. Anesthesia and analgesia 20071201
Sevoflurane directly excites locus coeruleus neurons of rats. Anesthesiology 20071201
Effects of epidural administration of dexmedetomidine on the minimum alveolar concentration of isoflurane in dogs. American journal of veterinary research 20071201
Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery. Journal of clinical anesthesia 20071201
Innovative uses of dexmedetomidine. Journal of clinical anesthesia 20071201
Perioperative medical management of patients with COPD. International journal of chronic obstructive pulmonary disease 20071201
Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles). Veterinary anaesthesia and analgesia 20071101
Effects of alpha2-adrenoceptor agonists on tetrodotoxin-resistant Na+ channels in rat dorsal root ganglion neurons. European journal of anaesthesiology 20071101
Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain. Pharmacology, biochemistry, and behavior 20071101
The impact of perioperative dexmedetomidine infusion on postoperative narcotic use and duration of stay after laparoscopic bariatric surgery. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20071101
A comparison of dexmedetomidine and midazolam for sedation in third molar surgery. Anaesthesia 20071101
Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071101
The effect of dexmedetomidine on electrocorticography in patients with temporal lobe epilepsy under sevoflurane anesthesia. Anesthesia and analgesia 20071101
Neural representation of spectral and temporal features of song in the auditory forebrain of zebra finches as revealed by functional MRI. The European journal of neuroscience 20071101
Comparison of subcutaneous and intramuscular ketamine-medetomidine with and without reversal by atipamezole in Dutch belted rabbits (Oryctolagus cuniculus). Journal of the American Association for Laboratory Animal Science : JAALAS 20071101
Effect of dexmedetomidine on blood pressure and bleeding in maxillo-facial surgery. European journal of anaesthesiology 20071101
Dexmedetomidine-induced pulmonary alterations in sheep. Research in veterinary science 20071001
Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats. Veterinary research communications 20071001
Dexmedetomidine as an analgesic for pediatric tonsillectomy and adenoidectomy. Paediatric anaesthesia 20071001
Dexmedetomidine sedation for the treatment of tetanus in the intensive care unit. British journal of anaesthesia 20071001
Autonomic dysfunction in tetanus - what lessons can be learnt with specific reference to alpha-2 agonists? Anaesthesia 20071001
A comparative clinical study of three different dosages of intramuscular midazolam-medetomidine-ketamine immobilization in cats. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071001
Activation of a G protein-coupled inwardly rectifying K+ current and suppression of Ih contribute to dexmedetomidine-induced inhibition of rat hypothalamic paraventricular nucleus neurons. Anesthesiology 20071001
Translational research: addressing problems facing the anesthesiologist. Anesthesia and analgesia 20071001
Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats. Anesthesia and analgesia 20071001
Dexmedetomidine relieves pain associated with acute sickle cell crisis. Journal of pain and symptom management 20071001
Dexmedetomidine produces dual alpha2-adrenergic agonist and alpha1-adrenergic antagonist actions on human isolated internal mammary artery. Journal of cardiothoracic and vascular anesthesia 20071001
[Efficacy of dexmedetomidine for controlling delirium in intensive care unit patients]. Masui. The Japanese journal of anesthesiology 20071001
[Usability of AirWay Scope for awake tracheal intubation in a burn patient with difficult airway]. Masui. The Japanese journal of anesthesiology 20071001
Effects of dexmedetomidine in morbidly obese patients undergoing laparoscopic gastric bypass. Middle East journal of anaesthesiology 20071001
Effects of ketamine or medetomidine administration on quality of electroejaculated sperm and on sperm flow in the domestic cat. Theriogenology 20070915
The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation 20070901
Dexmedetomidine for pediatric MRI sedation: a review of a series of cases. Paediatric anaesthesia 20070901
Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070901
Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?--A preliminary study. Acta anaesthesiologica Scandinavica 20070901
Dexmedetomidine sedation during cataract surgery under regional anaesthesia. British journal of anaesthesia 20070901
Deep sedation with dexmedetomidine in a porcine model does not compromise the viability of free microvascular flap as depicted by microdialysis and tissue oxygen tension. Anesthesia and analgesia 20070901
Dexmedetomidine related cardiac arrest in a patient with permanent pacemaker; a cautionary tale. Pacing and clinical electrophysiology : PACE 20070901
Dexmedetomidine: do we know enough? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070901
Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. Journal of the American College of Cardiology 20070814
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist. Journal of medicinal chemistry 20070809
Irradiation of rat brain reduces P-glycoprotein expression and function. British journal of cancer 20070806
Characterization of spinal alpha-adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats. British journal of pharmacology 20070801
Anesthesia in the patient for awake craniotomy. Current opinion in anaesthesiology 20070801
Non-anesthesiologist-provided pediatric procedural sedation: an update. Current opinion in anaesthesiology 20070801
Current state of sedation/analgesia care in dentistry. Current opinion in anaesthesiology 20070801
Current world literature. Current opinion in anaesthesiology 20070801
Neonates have a spinal alpha receptor too, as do adults. British journal of pharmacology 20070801
A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesthesia and analgesia 20070801
The effect of dexmedetomidine on middle ear pressure. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20070801
Influence of three anesthetic protocols on glomerular filtration rate in dogs. American journal of veterinary research 20070801
[Experience in postoperative sedation with dexmedetomidine for mandibular osteotomy]. Masui. The Japanese journal of anesthesiology 20070801
Dexmedetomidine as sole sedative for awake intubation in management of the critical airway. Journal of clinical anesthesia 20070801
Medetomidine as a candidate antifoulant: sublethal effects on juvenile turbot (Psetta maxima L.). Aquatic toxicology (Amsterdam, Netherlands) 20070720
Field anaesthesia of leatherback sea turtles (Dermochelys coriacea). The Veterinary record 20070707
Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes. The Journal of pharmacology and experimental therapeutics 20070701
Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men. The Journal of physiology 20070701
Ageing and vascular adrenoceptor desensitization: too little, too late? The Journal of physiology 20070701
Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells. Naunyn-Schmiedeberg's archives of pharmacology 20070701
Auditory cortical detection and discrimination correlates with communicative significance. PLoS biology 20070701
Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. Paediatric anaesthesia 20070701
A clinical comparison of two anaesthetic protocols using lidocaine or medetomidine in horses. Veterinary anaesthesia and analgesia 20070701
Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. Journal of neurosurgical anesthesiology 20070701
Differences in response to anaesthetics and analgesics between inbred rat strains. Laboratory animals 20070701
Evaluation of a medetomidine-midazolam combination for immobilizing and sedating Japanese monkeys (Macaca fuscata). Journal of the American Association for Laboratory Animal Science : JAALAS 20070701
Survey of utilization of medetomidine and atipamezole in private veterinary practice in Quebec in 2002. The Canadian veterinary journal = La revue veterinaire canadienne 20070701
Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. The Veterinary record 20070630
Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block. European journal of anaesthesiology 20070601
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium? European journal of anaesthesiology 20070601
Sensitive and specific liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in pediatric plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Premedication of the pediatric patient - anesthesia for the uncooperative child. Current opinion in anaesthesiology 20070601
Inhalation agents in pediatric anaesthesia - an update. Current opinion in anaesthesiology 20070601
Dexmedetomidine as a total intravenous anesthetic in infants. Paediatric anaesthesia 20070601
The effects of dexmedetomidine on myogenic motor evoked potentials in rabbits. Anesthesia and analgesia 20070601
[Airway management with dexmedetomidine for difficult airway]. Masui. The Japanese journal of anesthesiology 20070601
Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery. Journal of clinical anesthesia 20070601
Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine. Journal of clinical anesthesia 20070601
Dexmedetomidine: a novel anesthetic agent for middle ear surgery. Recent patents on CNS drug discovery 20070601
Effect of dexmedetomidine on bleeding during tympanoplasty or septorhinoplasty. European journal of anaesthesiology 20070501
Peri-operative body temperatures in isoflurane-anaesthetized rabbits following ketamine-midazolam or ketamine-medetomidine. Veterinary anaesthesia and analgesia 20070501
Lack in effects of therapeutic concentrations of dexmedetomidine and clonidine on the neuromuscular blocking action of rocuronium in isolated rat diaphragms. Anesthesia and analgesia 20070501
Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia: sevoflurane vs desflurane. Paediatric anaesthesia 20070501
[Dexmedetomidine is a useful concomitant anesthetic agent for perioperative management during tracheobronchial Dumon stent surgery]. Masui. The Japanese journal of anesthesiology 20070501
Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium. Environmental health perspectives 20070501
Sevoflurane anaesthesia in Iberian lynx (Lynx pardinus). The Veterinary record 20070428
Alternative to ganglionic blockade with anticholinergic and alpha-2 receptor agents. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20070401
Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats. Journal of feline medicine and surgery 20070401
Dexmedetomidine infusion as a supplement to isoflurane anaesthesia for vitreoretinal surgery. British journal of anaesthesia 20070401
Dexmedetomidine for the treatment of postanesthesia shivering in children. Paediatric anaesthesia 20070401
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. British journal of anaesthesia 20070401
Untying the Gordian knot. Anesthesia and analgesia 20070401
[Effect of dexmedetomidine on hemodynamics in pediatric patients following cardiac surgery]. Masui. The Japanese journal of anesthesiology 20070401
[The use of dexmedetomidine in neurosurgery.]. Revista brasileira de anestesiologia 20070401
Impact of sedation method on the diagnosis of hip and elbow dysplasia in Swedish dogs. Preventive veterinary medicine 20070317
Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. British journal of cancer 20070312
Intrathecal infusion therapy with dexmedetomidine-supplemented morphine in cancer pain. Acta anaesthesiologica Scandinavica 20070301
Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070301
Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters. Pharmacotherapy 20070301
Alpha2 adrenergic receptor-mediated modulation of cytosolic Ca++ signals at the inner plexiform layer of the rat retina. Investigative ophthalmology & visual science 20070301
Dexmedetomidine for conscious sedation in difficult awake fiberoptic intubation cases. Journal of clinical anesthesia 20070301
Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception. European journal of pharmacology 20070205
Cardiovascular reactivity to mental stress is not affected by alpha2-adrenoreceptor activation or inhibition. Psychopharmacology 20070201
Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. British journal of pharmacology 20070201
Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children. Paediatric anaesthesia 20070201
Loss of transcranial electric motor evoked potentials during pediatric spine surgery with dexmedetomidine. Anesthesiology 20070201
Procedural sedation and analgesia research: state of the art. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20070201
Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses. American journal of veterinary research 20070201
In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis. American journal of veterinary research 20070201
Dexmedetomidine: an updated review. The Annals of pharmacotherapy 20070201
A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. PLoS pathogens 20070201
Autonomic activity during dexmedetomidine or fentanyl infusion with desflurane anesthesia. Journal of clinical anesthesia 20070201
Total intravenous anaesthesia with propofol or propofol/ketamine in spontaneously breathing dogs premedicated with medetomidine. The Veterinary record 20070120
Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy. Acta anaesthesiologica Scandinavica 20070101
Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070101
Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography. Journal of neurosurgical anesthesiology 20070101
The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized study. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20070101
Post-anesthetic hyperthermia in cats. Veterinary anaesthesia and analgesia 20070101
Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis. Arthritis research & therapy 20070101
Alpha2-adrenoceptor agonists. Current opinion in investigational drugs (London, England : 2000) 20070101
Anesthetic and cardiopulmonary effects of total intravenous anesthesia using a midazolam, ketamine and medetomidine drug combination in horses. The Journal of veterinary medical science 20070101
Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. Critical care (London, England) 20070101
The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms. BMC pharmacology 20070101
XIAP protection of photoreceptors in animal models of retinitis pigmentosa. PloS one 20070101
Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation. Veterinary therapeutics : research in applied veterinary medicine 20070101
Arthritis and pain. Future targets to control osteoarthritis pain. Arthritis research & therapy 20070101
Effects of tribromoethanol-medetomidine combination on cycling and ovariectomized Sprague-Dawley rats. Lab animal 20070101
A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation. Journal of pharmacological and toxicological methods 20070101
Dexmedetomidine for the treatment of paroxysmal autonomic instability with dystonia. Neurocritical care 20070101
Use of dexmedetomidine in patients with trisomy 21 after cardiac surgery. Pediatric cardiology 20070101
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs. Veterinary therapeutics : research in applied veterinary medicine 20070101
Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine. Acta cirurgica brasileira 20070101
Renal function and histology after acute hemorrhage in rats under dexmedetomidine action. Acta cirurgica brasileira 20070101
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PloS one 20070101
Application of a zona pellucida binding assay (ZBA) in the domestic cat benefits from the use of in vitro matured oocytes. Acta veterinaria Scandinavica 20070101
Morphine reduces local cytokine expression and neutrophil infiltration after incision. Molecular pain 20070101
A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats. Veterinary therapeutics : research in applied veterinary medicine 20070101
Dopamine receptor repertoire of human granulosa cells. Reproductive biology and endocrinology : RB&E 20070101
Electroencephalography findings in healthy and Finnish Spitz dogs with epilepsy: visual and background quantitative analysis. Journal of veterinary internal medicine 20070101
Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex. Frontiers in integrative neuroscience 20070101
Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats. Respiratory physiology & neurobiology 20061201
Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam. European journal of anaesthesiology 20061201
Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neuroscience letters 20061201
Effects of a candidate antifouling compound (medetomidine) on pheromone induced mate search in the amphipod Corophium volutator. Marine pollution bulletin 20061201
Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. British journal of pharmacology 20061201
Prolonged use of dexmedetomidine in an infant with respiratory failure following living donor liver transplantation. Paediatric anaesthesia 20061201
Using dexmedetomidine to manage patients with cocaine and opioid withdrawal, who are undergoing cerebral angioplasty for cerebral vasospasm. Anesthesia and analgesia 20061201
Do the right thing (or Do the market exclusivity thing?). Anesthesiology 20061201
A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 20061201
Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs. American journal of veterinary research 20061201
[Effects of dexmedetomidine hydrochloride on postoperative sedation in cardiovascular surgery]. Kyobu geka. The Japanese journal of thoracic surgery 20061201
Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. Journal of clinical anesthesia 20061201
Anesthesia of male axis deer (Axis axis): evaluation of thiafentanil, medetomidine, and ketamine versus medetomidine and ketamine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201
Reversible anesthesia in wild marine otters (Lontra felina) using ketamine and medetomidine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201
Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). Journal of the South African Veterinary Association 20061201
Cardiopulmonary effects of dexmedetomidine in goats and sheep anaesthetised with sevoflurane. The Veterinary record 20061104
Complexation chemistry for tuning release from polymer coatings. The journal of physical chemistry. B 20061102
Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands. The Journal of pharmacology and experimental therapeutics 20061101
Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061101
Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study. British journal of anaesthesia 20061101
GLC756 decreases TNF-alpha via an alpha2 and beta2 adrenoceptor related mechanism. Experimental eye research 20061101
The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta anaesthesiologica Scandinavica 20061101
Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20061101
The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects. Anesthesia and analgesia 20061101
Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease. Anesthesia and analgesia 20061101
Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects. Anesthesiology 20061101
General anesthesia with dexmedetomidine in a malignant hyperthermia-susceptible woman. Acta anaesthesiologica Scandinavica 20061101
Dexmedetomidine for fiberoptic intubation of a patient with severe mental retardation and atlantoaxial instability. Acta anaesthesiologica Scandinavica 20061101
Clinical efficacy and safety of dexmedetomidine and buprenorphine, butorphanol or diazepam for canine hip radiography. The Journal of small animal practice 20061101
Effects of medetomidine, a novel antifouling agent, on the burrowing bivalve Abra nitida (Müller). Chemosphere 20061001
Effect of peripheral vasoconstriction on pulse oximetry. Journal of clinical monitoring and computing 20061001
Dexmedetomidine does not increase the incidence of intracarotid shunting in patients undergoing awake carotid endarterectomy. Anesthesia and analgesia 20061001
M-mode and Doppler echocardiographic reference values for male New Zealand white rabbits. American journal of veterinary research 20061001
Hemodynamic and anesthetic advantages of dexmedetomidine, an alpha 2-agonist, for surgery in prone position. The Tohoku journal of experimental medicine 20061001
Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20061001
[Anesthetic management of awake coronary artery bypass grafting using dexmedetomidine--high-dose administration and pharmacokinetic simulation]. Masui. The Japanese journal of anesthesiology 20061001
[Validity of intraoperative administration of dexmedetomidine in a patient with dermatomyositis-derived respiratory failure]. Masui. The Japanese journal of anesthesiology 20061001
Perioperative uses of dexmedetomidine. Middle East journal of anaesthesiology 20061001
Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons. Neuropharmacology 20060901
Dexmedetomidine versus midazolam in outpatient third molar surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20060901
Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060901
Dexmedetomidine infusion is associated with enhanced renal function after thoracic surgery. Journal of clinical anesthesia 20060901
Tracheal resection in the morbidly obese patient: the role of dexmedetomidine. Journal of clinical anesthesia 20060901
A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients: preliminary study. European journal of anaesthesiology 20060801
Response entropy is more reactive than bispectral index during laparoscopic gastric banding. Journal of clinical monitoring and computing 20060801
Clonidine decreases stress response in patients undergoing carotid endarterectomy under regional anesthesia: a prospective, randomized, double-blinded, placebo-controlled study. Anesthesia and analgesia 20060801
Propofol acts at the sigma-1 receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices. Acta anaesthesiologica Scandinavica 20060801
Effect of four sedative and anesthetic protocols on quantitative thyroid scintigraphy in euthyroid cats. American journal of veterinary research 20060801
Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization. Journal of cardiothoracic and vascular anesthesia 20060801
[Pharmacokinetic simulation of high-dose administration of dexmedetomidine for decubitus treatment]. Masui. The Japanese journal of anesthesiology 20060801
[Dexmedetomidine for neurocognitive testing in awake craniotomy: case report.]. Revista brasileira de anestesiologia 20060801
Opposite to alpha2-adrenergic agonists, an imidazoline I1 selective compound does not influence reflex bradycardia in rabbits. Autonomic neuroscience : basic & clinical 20060730
Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole. Veterinary anaesthesia and analgesia 20060701
Cerebral state monitoring in Beagle dogs sedated with medetomidine. Veterinary anaesthesia and analgesia 20060701
Pediatric research and scholarship: another Gordian knot? Anesthesia and analgesia 20060701
The use of dexmedetomidine in pediatric cardiac surgery. Anesthesia and analgesia 20060701
Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Anesthesia and analgesia 20060701
A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesthesia and analgesia 20060701
Short duration large dose dexmedetomidine in a pediatric patient during procedural sedation. Anesthesia and analgesia 20060701
Untying the Gordian knot. Anesthesia and analgesia 20060701
Preliminary experience with dexmedetomidine in pediatric anesthesia. Anesthesia and analgesia 20060701
Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060701
[Dexmedetomidine]. Masui. The Japanese journal of anesthesiology 20060701
Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery. Paediatric anaesthesia 20060701
Monitored anesthesia care with a combination of ketamine and dexmedetomidine during magnetic resonance imaging in three children with trisomy 21 and obstructive sleep apnea. Paediatric anaesthesia 20060701
Safety and efficacy of dexmedetomidine in neurosurgical patients. Brain injury 20060701
Use of dexmedetomidine versus general anesthesia for endovascular repair of abdominal aortic aneurysms. Proceedings (Baylor University. Medical Center) 20060701
Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways. Life sciences 20060620
Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods. European journal of clinical pharmacology 20060601
Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery. British journal of anaesthesia 20060601
Dexmedetomidine or medetomidine premedication before propofol-desflurane anaesthesia in dogs. Journal of veterinary pharmacology and therapeutics 20060601
Addition of dexmedetomidine to standard sedation regimens after cardiac surgery: an outcomes analysis. Pharmacotherapy 20060601
Propofol-induced dyskinesias controlled with dexmedetomidine during deep brain stimulation surgery. Anesthesiology 20060601
The effects of esmolol and dexmedetomidine on myocardial oxygen consumption during sympathetic stimulation in dogs. Journal of cardiothoracic and vascular anesthesia 20060601
A question of semantics. Journal of cataract and refractive surgery 20060601
Hemodynamic effects of dexmedetomidine in patients after cardiac surgery. Minerva chirurgica 20060601
Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601
Anesthesia of captive African wild dogs (Lycaon pictus) using a medetomidine-ketamine-atropine combination. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601
The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. The Journal of pharmacology and experimental therapeutics 20060501
Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient. European journal of anaesthesiology 20060501
Dexmedetomidine as rescue drug during awake craniotomy for cortical motor mapping and tumor resection. Anesthesia and analgesia 20060501
Use of dexmedetomidine to facilitate extubation in surgical intensive-care-unit patients who failed previous weaning attempts following prolonged mechanical ventilation: a pilot study. Respiratory care 20060501
Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogs. American journal of veterinary research 20060501
Evaluation of total intravenous anesthesia with propofol or ketamine-medetomidine-propofol combination in horses. Journal of the American Veterinary Medical Association 20060415
The correlation between the Richmond agitation-sedation scale and bispectral index during dexmedetomidine sedation. European journal of anaesthesiology 20060401
Dexmedetomidine facilitates withdrawal of ventilatory support. Anesthesiology 20060401
Suspected malignant hyperthermia in a child with laminin alpha2 (merosin) deficiency in the absence of a triggering agent. Paediatric anaesthesia 20060401
Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole. Journal of wildlife diseases 20060401
Evaluation of medetomidine/ketamine for short-term immobilization of variable flying foxes (Pteropus hypomelanus). Journal of wildlife diseases 20060401
[Dexmedetomidine in morbid obese patients undergoing gastroplasty: cardiovascular stability and consumption of intravenous anesthetics. A retrospective study.]. Revista brasileira de anestesiologia 20060401
Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060301
A2-agonists in sheep: a review. Veterinary anaesthesia and analgesia 20060301
Changes in the minimum alveolar concentration of isoflurane and some cardiopulmonary measurements during three continuous infusion rates of dexmedetomidine in dogs. Veterinary anaesthesia and analgesia 20060301
Dexmedetomidine for peri-operative sedation and analgesia in alcohol addiction. Anaesthesia 20060301
Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases. Paediatric anaesthesia 20060301
A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia. Anesthesia and analgesia 20060301
Differential effects of intravenous anesthetics on ciliary motility in cultured rat tracheal epithelial cells. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060301
Pediatric sedation: Still a hard long way to go. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060301
The adrenergic alpha2 receptor and sexual incentive motivation in male rats. Pharmacology, biochemistry, and behavior 20060301
Update on bispectral index monitoring. Best practice & research. Clinical anaesthesiology 20060301
The influence of the time course of inflammation and spinalization on the antinociceptive activity of the alpha2-adrenoceptor agonist medetomidine. European journal of pharmacology 20060217
A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. NeuroImage 20060215
Comparative pharmacokinetics of medetomidine enantiomers in goats and sheep during sevoflurane anaesthesia. Journal of veterinary pharmacology and therapeutics 20060201
Dexmedetomidine and meperidine prevent postanaesthetic shivering. European journal of anaesthesiology 20060201
Dexmedetomidine-induced decreases in accumbal dopamine in the rat are partly mediated via the locus coeruleus. Anesthesia and analgesia 20060201
The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesthesia and analgesia 20060201
Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. Acta anaesthesiologica Scandinavica 20060201
Dexmedetomidine as a sole sedating agent with local anesthesia in a high risk patient for axillofemoral bypass graft. AANA journal 20060201
Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery. Journal of clinical anesthesia 20060201
[Intravenous dexmedetomidine for sedation does not interfere with sensory and motor block duration during spinal anesthesia.]. Revista brasileira de anestesiologia 20060201
Echocardiographic and Doppler echocardiographic findings in 11 wolves (Canis lupus). The Veterinary record 20060128
Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs. Journal of the American Animal Hospital Association 20060101
Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs. Veterinary ophthalmology 20060101
Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep. Veterinary anaesthesia and analgesia 20060101
Dexmedetomidine during local anesthesia. Journal of anesthesia 20060101
[Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage]. Masui. The Japanese journal of anesthesiology 20060101
Cardiorespiratory and minimum alveolar concentration sparing effects of a continuous intravenous infusion of dexmedetomidine in halothane or isoflurane-anaesthetized rats. Laboratory animals 20060101
Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behaviour after abdominal surgery in pigs. Laboratory animals 20060101
Successful protocol of anaesthesia for measuring transepithelial nasal potential difference in spontaneously breathing mice. Laboratory animals 20060101
[Dexmedetomidine as preventive postoperative analgesia in inguinal hernioplasty]. Gaceta medica de Mexico 20060101
Sedation using dexmedetomidine in pediatric burn patients. Journal of burn care & research : official publication of the American Burn Association 20060101
Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation : perioperative haemodynamics and anaesthetic requirements. Drugs in R&D 20060101
Dexmedetomidine: a novel analgesic with palliative medicine potential. Journal of pain & palliative care pharmacotherapy 20060101
Dissociative anaesthesia during field and hospital conditions for castration of colts. Acta veterinaria Scandinavica 20060101
The effects of dexmedetomidine on spontaneous contractions of isolated gravid rat myometrium. Advances in therapy 20060101
Dexmedetomidine as an adjuvant in the treatment of alcohol withdrawal delirium: a case report. General hospital psychiatry 20060101
Brain dysfunction in critically ill patients--the intensive care unit and beyond. Critical care (London, England) 20060101
Effects of dexmedetomidine on cerebral circulation and systemic hemodynamics after cardiopulmonary resuscitation in dogs. Journal of anesthesia 20060101
Repeated dexmedetomidine infusions, a postoperative living-donor liver transplantation patient. Journal of anesthesia 20060101
An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones. BMC musculoskeletal disorders 20060101
Systemic analgesia and co-analgesia. Acta anaesthesiologica Belgica 20060101
Neuraxial drug administration: a review of treatment options for anaesthesia and analgesia. CNS drugs 20060101
Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics. Critical care (London, England) 20060101
Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU. Journal of opioid management 20060101
Evaluation of sedation on electroencephalographic spectral edge frequency 95 in dogs sedated by acupuncture at GV20 or Yintang and sedative combination. Acupuncture & electro-therapeutics research 20060101
Dexmedetomidine: a new alpha-agonist anesthetic agent for facial rejuvenation surgery. Aesthetic surgery journal 20060101
Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits. Irish veterinary journal 20060101
Central apnoea after balanced general anaesthesia that included dexmedetomidine. British journal of anaesthesia 20051201
Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia? Paediatric anaesthesia 20051201
Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe. Journal of the South African Veterinary Association 20051201
Alpha(1)-adrenergic and alpha(2)-adrenergic balance in the dorsal pons and gross behavioral activity of mice in a novel environment. Psychopharmacology 20051101
Preliminary experience with oral dexmedetomidine for procedural and anesthetic premedication. Paediatric anaesthesia 20051101
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Anesthesiology 20051101
Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs. The Journal of pharmacy and pharmacology 20051101
Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environmental health perspectives 20051101
Total intravenous anaesthesia in horses using medetomidine and propofol. Veterinary anaesthesia and analgesia 20051101
The use and assessment of ketamine-medetomidine-butorphanol combinations for field anaesthesia in wild European badgers (Meles meles). Veterinary anaesthesia and analgesia 20051101
Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice. European journal of pharmacology 20051031
Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements. Anesthesia and analgesia 20051001
A prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery. Journal of cardiothoracic and vascular anesthesia 20051001
Romifidine or medetomidine premedication before propofol-sevoflurane anaesthesia in dogs. Journal of veterinary pharmacology and therapeutics 20051001
Dexmedetomidine as a sole sedating agent with local anesthesia in a high-risk patient for axillofemoral bypass graft: a case report. AANA journal 20051001
[Effects of dexmedetomidine on intracranial hemodynamics in severe head injured patients]. Neurocirugia (Asturias, Spain) 20051001
[Intraoperative analgesic effect of epidural ketamine, clonidine or dexmedetomidine for upper abdominal surgery.]. Revista brasileira de anestesiologia 20051001
Expression and function of alpha-adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions. Journal of neurochemistry 20050901
Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation. Acta anaesthesiologica Scandinavica 20050901
Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy. Paediatric anaesthesia 20050901
Tolerance and withdrawal issues with sedation. Critical care nursing clinics of North America 20050901
Long-term changes in the antinociceptive potency of morphine or dexmedetomidine after a single treatment. Anesthesia and analgesia 20050901
Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits. Veterinary anaesthesia and analgesia 20050901
Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit. Veterinary anaesthesia and analgesia 20050901
The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children. Critical care medicine 20050901
Medications to provide cooperation in the critically ill pediatric patient: a rose with a thorn. Critical care medicine 20050901
[Sedation of a pediatric patient using dexmedetomidine for day-care MRI]. Masui. The Japanese journal of anesthesiology 20050901
[Postoperative management and extubation under sedation using dexmedetomidine in a patient with old myocardial infarction after carotid endarterectomy]. Masui. The Japanese journal of anesthesiology 20050901
Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: multi-residue screening by liquid chromatography-mass spectrometry. Journal of analytical toxicology 20050901
Comparison of dexmedetomidine and midazolam sedation for cataract surgery under topical anesthesia. Journal of cataract and refractive surgery 20050901
Dexmedetomidine for awake craniotomy without laryngeal mask. Arquivos de neuro-psiquiatria 20050901
Cardiopulmonary effects of dexmedetomidine in sevoflurane-anesthetized sheep with and without nitric oxide inhalation. American journal of veterinary research 20050901
Acute aortic rupture in a dog with spirocercosis following the administration of medetomidine. Journal of the South African Veterinary Association 20050901
Effects of opioid receptor and alpha2-adrenoceptor agonists on slow ventral root potentials and on capsaicin and formalin tests in neonatal rats. Brain research. Developmental brain research 20050808
Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm. Journal of applied physiology (Bethesda, Md. : 1985) 20050801
Dexmedetomidine in the treatment of cyclic vomiting syndrome. Paediatric anaesthesia 20050801
The use of a medetomidine, butorphanol and atropine combination to enable blood sampling in young pigs. New Zealand veterinary journal 20050801
Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology 20050801
Dexmedetomidine facilitates the withdrawal of ventilatory support in palliative care. Anesthesiology 20050801
Dexmedetomidine--does it have a role in the perioperative setting? Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20050801
Sedation and analgesia in the pediatric intensive care unit. Pediatric annals 20050801
Evaluation of the cardiovascular effects of an anaesthetic protocol for immobilization and anaesthesia in grey wolves (Canis lupus L, 1758). Veterinary research communications 20050801
Dexmedetomidine in anaesthesia. Current opinion in anaesthesiology 20050801
Effects of dexmedetomidine on renal system and on vasopressin plasma levels. Experimental study in dogs. Revista brasileira de anestesiologia 20050801
Comparison of xylazine and medetomidine as premedicants for cats being anaesthetised with propofol-sevoflurane. The Veterinary record 20050730
Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology 20050701
Evidence for different pharmacological targets for imidazoline compounds inhibiting settlement of the barnacle Balanus improvisus. Journal of experimental zoology. Part A, Comparative experimental biology 20050701
Prolonged infusion of dexmedetomidine for sedation following tracheal resection. Paediatric anaesthesia 20050701
Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050701
Dexmedetomidine for neurological surgery. Neurosurgery 20050701
Dexmedetomidine: promising drug for pediatric sedation? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050701
Transcanal cochlear implantation under monitored anesthesia care. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20050701
Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. American journal of veterinary research 20050701
Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. British journal of anaesthesia 20050601
Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Pharmacogenetics and genomics 20050601
Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups. Anesthesiology 20050601
Addition of dexmedetomidine to lidocaine for intravenous regional anaesthesia. European journal of anaesthesiology 20050601
Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats. Comparative medicine 20050601
Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Anesthesia and analgesia 20050501
Case series or uncontrolled clinical study? Anesthesiology 20050501
Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Pharmacogenetics and genomics 20050501
The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050501
Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Veterinary anaesthesia and analgesia 20050501
Effect of medetomidine and its antagonism with atipamezole on stress-related hormones, metabolites, physiologic responses, sedation, and mechanical threshold in goats. Veterinary anaesthesia and analgesia 20050501
Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Critical care medicine 20050501
'If you cannot measure it, you cannot improve it'. Critical care medicine 20050501
The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine. European journal of anaesthesiology 20050501
The role of alpha2-agonists in neurosurgery. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501
Renal effects of medetomidine in isoflurane-anesthetized dogs with special reference to its diuretic action. The Journal of veterinary medical science 20050501
The in vitro effects of clonidine and dexmedetomidine on human myometrium. International journal of obstetric anesthesia 20050401
Preventing pain on injection of rocuronium: two doses of dexmedetomidine. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050401
Dexmedetomidine and awake fiberoptic intubation for possible cervical spine myelopathy: a clinical series. Journal of neurosurgical anesthesiology 20050401
Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamine-medetomidine with inhalation of oxygen-sevoflurane (MKM-OS anesthesia) in horses. The Journal of veterinary medical science 20050401
Use of medetomidine-ketamine and atipamezole for reversible immobilization of free-ranging hog deer (Axis porcinus) captured in drive nets. Journal of wildlife diseases 20050401
[Dexmedetomidine in general anesthesia for surgical treatment of cerebral aneurysm in pregnant patient with specific hypertensive disease of pregnancy: case report.]. Revista brasileira de anestesiologia 20050401
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. Journal of medicinal chemistry 20050324
Rescue sedation with dexmedetomidine for diagnostic imaging: a preliminary report. Paediatric anaesthesia 20050301
Dexmedetomidine as the primary sedative agent for brain radiation therapy in a 21-month old child. Paediatric anaesthesia 20050301
The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts. Anesthesia and analgesia 20050301
Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions. Anesthesia and analgesia 20050301
Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Anesthesiology 20050301
Ebola virus antibody prevalence in dogs and human risk. Emerging infectious diseases 20050301
Results of 24-hour ambulatory electrocardiography in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine. Journal of the American Veterinary Medical Association 20050301
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice. British journal of pharmacology 20050301
Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl, and ketamine administration in dogs. American journal of veterinary research 20050301
Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine. Journal of the South African Veterinary Association 20050301
Dexmedetomidine in awake craniotomy: a technical note. Surgical neurology 20050201
Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050201
Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions. Lab animal 20050201
New anesthesia techniques. Thoracic surgery clinics 20050201
Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine. American journal of veterinary research 20050201
[Analgesic efficacy of dexmedetomidine as compared to sufentanil in intraperitoneal surgeries: comparative study.]. Revista brasileira de anestesiologia 20050201
Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochemical pharmacology 20050115
Synergy between intrathecal omega-conotoxin CVID and dexmedetomidine to attenuate mechanical hypersensitivity in the rat. European journal of pharmacology 20050104
Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies. Equine veterinary journal 20050101
Preliminary comparison of four anaesthetic techniques in badgers (Meles meles). Veterinary anaesthesia and analgesia 20050101
High rectal temperature indicates an increased risk of unexpected recovery in anaesthetized badgers. Veterinary anaesthesia and analgesia 20050101
Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive care unit patients: a prospective study. Critical care (London, England) 20050101
Tribromoethanol-medetomidine combination provides a safe and reversible anesthetic effect in Sprague-Dawley rats. Contemporary topics in laboratory animal science 20050101
Medetomidine with ketamine and bupivacaine for epidural analgesia in buffaloes. Veterinary research communications 20050101
Bronchodilators in bronchoscopy-induced airflow limitation in allergen-sensitized cats. Journal of veterinary internal medicine 20050101
Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients. Journal of intensive care medicine 20050101
Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. Pharmacogenetics and genomics 20050101
Pre-injury administration of morphine prevents development of neuropathic hyperalgesia through activation of descending monoaminergic mechanisms in the spinal cord in mice. Molecular pain 20050101
Narcotic-based sedation regimens for critically ill mechanically ventilated patients. Critical care (London, England) 20050101
Dexmedetomidine sedation in a pediatric cardiac patient scheduled for MRI. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101
Dexmedetomidine is a useful adjunct for awake intubation. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101
Use of dexmedetomidine in a pediatric heart transplant patient. Pediatric cardiology 20050101
Effect of subhypnotic doses of dexmedetomidine on antitumor immunity in mice. Immunopharmacology and immunotoxicology 20050101
The effect of transdermal delivery of fentanyl on activity in growing pigs. Acta veterinaria Scandinavica 20050101
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration. Respiratory research 20050101
Formalin injection causes a coordinated spinal cord CO/NO-cGMP signaling system response. Molecular pain 20050101
The effect of cartilage and bone density of mushroom-shaped, photooxidized, osteochondral transplants: an experimental study on graft performance in sheep using transplants originating from different species. BMC musculoskeletal disorders 20050101
Sublethal effects of a new antifouling candidate on lumpfish (Cyclopterus lumpus L.) and Atlantic cod (Gadus morhua L.) larvae. Biofouling 20050101
Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects. Intensive care medicine 20041201
Dexmedetomidine for resection of a large phaeochromocytoma with invasion into the inferior vena cava. British journal of anaesthesia 20041201
Cardiac arrest, a preventable yet a possible risk of dexmedetomidine: fact or fiction? Anesthesiology 20041201
Dexmedetomidine and asystole. Anesthesiology 20041201
Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20041201
Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: haemodynamic effects and efficacy. Anaesthesia and intensive care 20041201
Sedation for paediatric stereotactic radiosurgery: the dexmedetomidine experience. Anaesthesia and intensive care 20041201
Bartonella clarridgeiae and B. henselae in dogs, Gabon. Emerging infectious diseases 20041201
Comparison of the effects of dexmedetomidine and esmolol on myocardial oxygen consumption in dogs. European journal of anaesthesiology 20041201
Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20041201
Mild cognitive impairment: animal models. Dialogues in clinical neuroscience 20041201
Supraclinical concentrations of dexmedetomidine evoke norepinephrine release from rat cerebrocortical slices possible involvement of the orexin-1 receptor. Neuroscience letters 20041130
Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice. European journal of pharmacology 20041128
Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Anesthesiology 20041101
Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 20041101
Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 20041101
[Analgesia and sedation in intensive care medicine]. Der Anaesthesist 20041101
Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. European journal of pharmacology 20041011
Pain management in cats--past, present and future. Part 2. Treatment of pain--clinical pharmacology. Journal of feline medicine and surgery 20041001
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens. Journal of neurochemistry 20041001
Information loss over time defines the memory defect of propofol: a comparative response with thiopental and dexmedetomidine. Anesthesiology 20041001
Reversal of medetomidine-ketamine combination anesthesia in rabbits by atipamezole. Experimental animals 20041001
Dexmedetomidine as primary sedative in CEA patients. Journal of neurosurgical anesthesiology 20041001
Immobilization of Chacoan peccaries (Catagonus wagneri) using medetomidine, Telazol, and ketamine. Journal of wildlife diseases 20041001
Enhanced visual memory effect for negative versus positive emotional content is potentiated at sub-anaesthetic concentrations of thiopental. British journal of anaesthesia 20040901
Dexmedetomidine: another arrow for the clinician's quiver. Anesthesiology 20040901
Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology 20040901
Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology 20040901
[Dexmedetomidine hydrochloride (Precedex), a new sedative in intensive care, its pharmacological characteristics and clinical study result]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040901
Xylazine-midazolam-ketamine versus medetomidine-midazolam-ketamine anesthesia in captive Siberian tigers (Panthera tigris altaica). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040901
Dexmedetomidine vs. propofol for short-term sedation of postoperative mechanically ventilated patients. Journal of the Egyptian National Cancer Institute 20040901
The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. European journal of pharmacology 20040823
Evaluation of the effects of premedication on gastroduodenoscopy in cats. Journal of the American Veterinary Medical Association 20040815
Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation. Biochemical and biophysical research communications 20040813
Duplicate publication. Dexmedetomidine in pediatrics: controlled studies needed. Paediatric anaesthesia 20040801
Intramuscular anesthesia of bonito and Pacific mackerel with ketamine and medetomidine and reversal of anesthesia with atipamezole. Journal of the American Veterinary Medical Association 20040801
[Epidural clonidine or dexmedetomidine for post-cholecystectomy analgesia and sedation.]. Revista brasileira de anestesiologia 20040801
Gross mapping of alpha1-adrenoceptors that regulate behavioral activation in the mouse brain. Behavioural brain research 20040709
Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040701
Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia. Anesthesiology 20040701
Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. American journal of veterinary research 20040701
In-vitro contraction of the equine aortic valve. The Journal of heart valve disease 20040701
Dexmedetomidine in pediatrics: controlled studies needed. Paediatric anaesthesia 20040601
The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant. Anesthesia and analgesia 20040601
Dexmedetomidine in pediatrics: controlled studies needed. Anesthesia and analgesia 20040601
Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology 20040601
Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Critical care medicine 20040601
Effect of medetomidine on breathing and inspiratory neuromuscular drive in conscious dogs. American journal of veterinary research 20040601
Difficult extubation: calming the sympathetic storm. Anaesthesia and intensive care 20040601
Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins. The Canadian veterinary journal = La revue veterinaire canadienne 20040601
Anaesthesia with midazolam/medetomidine/fentanyl in chinchillas (Chinchilla lanigera) compared to anaesthesia with xylazine/ketamine and medetomidine/ketamine. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20040601
Pediatric sedation. Current opinion in anaesthesiology 20040601
[Relationship between dexmedetomidine continuous infusion and end-tidal sevoflurane concentration, monitored by bispectral analysis.]. Revista brasileira de anestesiologia 20040601
Dexmedetomidine overdose in the perioperative setting. The Annals of pharmacotherapy 20040501
Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. NeuroImage 20040501
Sedation during mechanical ventilation in infants and children: dexmedetomidine versus midazolam. Southern medical journal 20040501
The effect of tiletamine/zolazepam (Zoletile) combination with xylazine or medetomidine on electroencephalograms in dogs. The Journal of veterinary medical science 20040501
Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects. Canadian journal of physiology and pharmacology 20040501
Impact of polymer surface affinity of novel antifouling agents. Biotechnology and bioengineering 20040405
Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects. Journal of neurosurgical anesthesiology 20040401
The effect of four anesthetic protocols on splenic size in dogs. Veterinary anaesthesia and analgesia 20040401
Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs. Veterinary anaesthesia and analgesia 20040401
Assessment of dexmedetomidine/ketamine anesthesia in golden-headed lion tamarins (Leontopithecus chrysomelas). Veterinary anaesthesia and analgesia 20040401
Dexmedetomidine in combination with morphine PCA provides superior analgesia for shockwave lithotripsy. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040401
Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Anesthesiology 20040401
[Remifentanil versus dexmedetomidine as coadjutants of standardized anesthetic technique in morbidly obese patients.]. Revista brasileira de anestesiologia 20040401
[Dexmedetomidine as adjuvant drug for wake-up test during scoliosis correction surgery: case report.]. Revista brasileira de anestesiologia 20040401
Experimental comparison of ketamine with a combination of ketamine, butorphanol and medetomidine for general anaesthesia of the Eurasian badger (Meles meles L.). Veterinary journal (London, England : 1997) 20040301
Adding dexmedetomidine to lidocaine for intravenous regional anesthesia. Anesthesia and analgesia 20040301
Dexmedetomidine and cardiac arrest. Anesthesiology 20040301
Dexmedetomidine infusion for sedation during fiberoptic intubation: a report of three cases. Journal of clinical anesthesia 20040301
Reversible anesthesia of captive California sea lions (Zalophus californianus) with medetomidine, midazolam, butorphanol, and isoflurane. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040301
Immobilisation of impala (Aepyceros melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination, and reversal with atipamezole hydrochloride. Journal of the South African Veterinary Association 20040301
[Clonidine and anesthesia]. La Tunisie medicale 20040301
Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201
Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs. Anesthesiology 20040201
Hypothermia attenuates the vasodilator effects of dexmedetomidine on pial vessels in rabbits in vivo. Anesthesia and analgesia 20040201
Stress-mediated modulation of B(alpha)P-induced hepatic CYP1A1: role of catecholamines. Chemico-biological interactions 20040115
Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites. Hypertension (Dallas, Tex. : 1979) 20040101
Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical pharmacology 20040101
Dexmedetomidine and neurocognitive testing in awake craniotomy. Journal of neurosurgical anesthesiology 20040101
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children. Anesthesia and analgesia 20040101
The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesthesia and analgesia 20040101
Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine. Laboratory animals 20040101
A comparison of xylazine and medetomidine in an anesthetic combination in New Zealand White Rabbits. Contemporary topics in laboratory animal science 20040101
Neuroprotective properties of different anesthetics on axotomized rat retinal ganglion cells in vivo. Journal of neurotrauma 20040101
An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane. BMC musculoskeletal disorders 20040101
Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data. The Annals of pharmacotherapy 20040101
Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS drug reviews 20040101
Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection. Rapid communications in mass spectrometry : RCM 20040101
Addition of dexmedetomidine prolongs duration of vasodilation induced by sympathetic block with mepivacaine in dogs. Regional anesthesia and pain medicine 20040101
Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Critical care (London, England) 20040101
Effects of ovariohysterectomy on canine blood neutrophil respiratory burst: a chemiluminescence study. Veterinary surgery : VS 20040101
A new method using flow cytometry to measure the effects of drugs on gastric emptying and gastrointestinal transit in mice. Arzneimittel-Forschung 20040101
All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology 20031201
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects. British journal of clinical pharmacology 20031201
Medetomidine-ketamine-butorphanol anesthetic combinations in binturongs (Arctictis binturong). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20031201
[Effects of dexmedetomidine on blood coagulation evaluated by thromboelastography.]. Revista brasileira de anestesiologia 20031201
[Cardiovascular effects of two dexmedetomidine doses: experimental study in dogs.]. Revista brasileira de anestesiologia 20031201
[Clonidine as adjuvant therapy for alcohol withdrawal syndrome in intensive care unit: case report.]. Revista brasileira de anestesiologia 20031201
The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats. Naunyn-Schmiedeberg's archives of pharmacology 20031101
The effect of intrathecal medetomidine on small bowel transit in the rat. European journal of anaesthesiology 20031101
A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. The Canadian veterinary journal = La revue veterinaire canadienne 20031101
Clinical use of dexmedetomidine as premedicant in cats undergoing propofol-sevoflurane anaesthesia. Journal of feline medicine and surgery 20031001
Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 20031001
ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. Journal of cardiothoracic and vascular anesthesia 20031001
Effects of midazolam-butorphanol, acepromazine-butorphanol and medetomidine on an induction dose of propofol and their compatibility in dogs. The Journal of veterinary medical science 20031001
Influence of yohimbine and atipamezole on haemodynamics and ECG after lumbosacral subarachnoid administration of medetomidine in goats. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031001
Additional experience with dexmedetomidine in pediatric patients. Southern medical journal 20030901
Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901
Anesthetic induction of captive tigers (Panthera tigris) using a medetomidine-ketamine combination. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901
Pharmacokinetics and sedative effects of intramuscular medetomidine in domestic sheep. Journal of veterinary pharmacology and therapeutics 20030801
Facilitation from ventral premotor cortex of primary motor cortex outputs to macaque hand muscles. Journal of neurophysiology 20030801
[Hemodynamic and metabolic evaluation of dexmedetomidine and remifentanil continuous infusion in videolaparoscopic cholecystectomy: comparative study]. Revista brasileira de anestesiologia 20030801
Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation. Brain research 20030718
Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor. Biochemical and biophysical research communications 20030711
Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Anesthesiology 20030701
Measurement of the low-frequency component of blood pressure variability can assist the interpretation of heart rate variability data. Anesthesiology 20030701
Awake craniotomy with dexmedetomidine in pediatric patients. Journal of neurosurgical anesthesiology 20030701
Different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-A knockout mice. The European journal of neuroscience 20030701
Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats. Contemporary topics in laboratory animal science 20030701
Evaluation of three combinations of anesthetics for use in free-ranging alpine marmots (Marmota marmota). Journal of wildlife diseases 20030701
Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis. The American journal of medicine 20030615
Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. Neuropharmacology 20030601
A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs. Journal of veterinary pharmacology and therapeutics 20030601
Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics. Anesthesia and analgesia 20030601
Is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats? Anesthesiology 20030601
Evaluation of propofol and medetomidine-ketamine for short-term immobilization of Gulf of Mexico sturgeon (Acipenser oxyrinchus de soti). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601
Comparison of the efficacy and cardiorespiratory effects of medetomidine-based anesthetic protocols in ring-tailed lemurs (Lemur catta). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601
Immobilization of sun bears (Helarctos malayanus) with medetomidine-zolazepam-tiletamine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601
The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model. Neuroscience letters 20030529
[Domitor not to used in collies?]. Tijdschrift voor diergeneeskunde 20030515
Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets. The Veterinary record 20030510
Dexmedetomidine and meperidine additively reduce the shivering threshold in humans. Stroke 20030501
Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects. Equine veterinary journal 20030501
Agonist-dependent trafficking of alpha2-adrenoceptor subtypes: dependence on receptor subtype and employed agonist. European journal of cell biology 20030501
Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium. The Journal of physiology 20030415
Endogenous opioids support the spinal inhibitory action of an alpha 2-adrenoceptor agonist in the decerebrated, spinalised rabbit. Neuroscience letters 20030410
Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal. Anesthesia and analgesia 20030401
Preservation of the cortical somatosensory-evoked potential during dexmedetomidine infusion in rats. Anesthesia and analgesia 20030401
Development of bradycardia during sedation with dexmedetomidine in an infant concurrently receiving digoxin. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030401
Immobilization of free-ranging European mink (Mustela lutreola) an polecat (Mustela putorius) with medetomidine-ketamine and reversal by atipamezole. Journal of wildlife diseases 20030401
Identification and characterization of the imidazoline I2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors. Archives of physiology and biochemistry 20030401
[Dexmedetomidine/propofol association for plastic surgery sedation during local anesthesia.]. Revista brasileira de anestesiologia 20030401
Strain differences in response to propofol, ketamine and medetomidine in rabbits. The Veterinary record 20030308
Dexmedetomidine decreases perioperative myocardial lactate release in dogs. Anesthesia and analgesia 20030301
Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Acta anaesthesiologica Scandinavica 20030301
Effect of medetomidine administration on bispectral index measurements in dogs during anesthesia with isoflurane. American journal of veterinary research 20030301
Comparison of the cardiorespiratory effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol-midazolam in patas monkeys (Erythrocebus patas). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030301
Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. Life sciences 20030214
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesthesia and analgesia 20030201
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 20030201
Dexmedetomidine to facilitate drug withdrawal. Anesthesiology 20030201
A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive care medicine 20030201
Postoperative analgesia in dogs receiving epidural morphine plus medetomidine. Journal of veterinary pharmacology and therapeutics 20030201
[Dexmedetomidine in anesthesiology.]. Revista brasileira de anestesiologia 20030201
Isoflurane to prolong medetomidine/ ketamine anaesthesia in six adult female chimpanzees (Pan troglodytes). The Veterinary record 20030104
Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration. Anesthesia and analgesia 20030101
[Development of opioid tolerance -- molecular mechanisms and clinical consequences]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20030101
Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine-butorphanol, and dexmedetomidine-ketamine in cats. Journal of the American Veterinary Medical Association 20030101
The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20030101
Cardiovascular reflex responses after intrathecal omega-conotoxins or dexmedetomidine in the rabbit. Clinical and experimental pharmacology & physiology 20030101
Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogs. Veterinary surgery : VS 20030101
Dexmedetomidine and low-dose ketamine provide adequate sedation for awake fibreoptic intubation. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030101
Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome. American journal of therapeutics 20030101
Comparison of sufentanil with sufentanil plus magnesium sulphate for sedation in the intensive care unit using bispectral index. Critical care (London, England) 20030101
The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. Journal of intensive care medicine 20030101
Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct. Kidney international 20021201
Medetomidine a novel immobilizing agent for the elephant (Elephas maximus). Research in veterinary science 20021201
Clonidine and dexmedetomidine potently inhibit peristalsis in the Guinea pig ileum in vitro. Anesthesiology 20021201
Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs. American journal of veterinary research 20021201
Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology 20021201
Surgical implantation of radio transmitters in arctic foxes (Alopex lagopus) on Svalbard, Norway. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201
Medetomidine-ketamine in reindeer (Rangifer tarandus tarandus): effective immobilization by hand- and dart-administered injection. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201
[Next generation of drugs used in anesthesia]. Masui. The Japanese journal of anesthesiology 20021201
Sedation and chemical restraint of deer. New Zealand veterinary journal 20021201
Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats. Journal of the American Veterinary Medical Association 20021101
24-hour Holter-monitoring in the perianaesthetic period in dogs premedicated with dexmedetomidine. Veterinary journal (London, England : 1997) 20021101
Clinical comparison of xylazine and medetomidine for premedication of horses. Journal of the American Veterinary Medical Association 20021015
Infusion of guaifenesin, ketamine, and medetomidine in combination with inhalation of sevoflurane versus inhalation of sevoflurane alone for anesthesia of horses. Journal of the American Veterinary Medical Association 20021015
Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesthesia and analgesia 20021001
Medetomidine, ketamine, and sevoflurane for anesthesia of injured loggerhead sea turtles: 13 cases (1996-2000). Journal of the American Veterinary Medical Association 20021001
[Preliminary experience with dexmedetomidine treatment of confusional state and hyperadrenergic states at an intensive care unit]. Revista espanola de anestesiologia y reanimacion 20021001
[Dexmedetomidine, a promising drug]. Revista espanola de anestesiologia y reanimacion 20021001
New concepts in intensive care: dexmedetomidine and immunonutrition. Middle East journal of anaesthesiology 20021001
Dexmedetomidine: a novel drug for sedation and analgesia in the ICU. Middle East journal of anaesthesiology 20021001
Dexmedetomidine: a sedative-analgesic drug for the 21st century. Middle East journal of anaesthesiology 20021001
Dexmedetomidine in intensive care unit: a study of hemodynamic changes. Middle East journal of anaesthesiology 20021001
Phase III study on dexmedetomidine used for postoperative sedation of patients requiring mechanical ventilation for less than 24 hours: the French experience. Middle East journal of anaesthesiology 20021001
Autonomic nervous system responses during sedative infusions of dexmedetomidine. Anesthesiology 20020901
Dexmedetomidine increases the cocaine seizure threshold in rats. Anesthesiology 20020901
The cardiovascular and respiratory effects of medetomidine and thiopentone anaesthesia in dogs breathing at an altitude of 1486 m. Journal of the South African Veterinary Association 20020901
[Dexmedetomidine and sufentanil as intraoperative analgesics: comparative study.]. Revista brasileira de anestesiologia 20020901
[Dexmedetomidine: pharmacology and clinical application.]. Revista brasileira de anestesiologia 20020901
Treatment of persistent tachycardia with dexmedetomidine during off-pump cardiac surgery. Anesthesia and analgesia 20020801
The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesthesia and analgesia 20020801
Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020801
Effect of synthesis parameters of the sol-gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine. Biomaterials 20020701
Effects of medetomidine-midazolam, midazolambutorphanol, or acepromazine-butorphanol as premedicants for mask induction of anesthesia with sevoflurane in dogs. American journal of veterinary research 20020701
Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication. American journal of veterinary research 20020701
Reliability of goniometry in Labrador Retrievers. American journal of veterinary research 20020701
The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits. Intensive care medicine 20020701
Dexmedetomidine may impair cognitive testing during endovascular embolization of cerebral arteriovenous malformations: a retrospective case report series. Journal of neurosurgical anesthesiology 20020701
Dexmedetomidine: a new option for intractable distress in the dying. Journal of pain and symptom management 20020701
Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain. American journal of physiology. Heart and circulatory physiology 20020601
Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries. Anesthesia and analgesia 20020601
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex. The European journal of neuroscience 20020601
Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Anesthesiology 20020601
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020601
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. The Journal of biological chemistry 20020531
Cardiopulmonary effects of a medetomidine-ketamine combination administered intravenously in gopher tortoises. Journal of the American Veterinary Medical Association 20020515
alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. American journal of physiology. Renal physiology 20020501
Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Critical care medicine 20020501
New agents, new monitors, same unanswered questions. Critical care medicine 20020501
Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience 20020501
Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. British journal of anaesthesia 20020501
Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020501
Anesthesia of boma-captured Lichtenstein's hartebeest (Sigmoceros lichtensteinii) with a combination of thiafentanil, medetomidine, and ketamine. Journal of wildlife diseases 20020401
Influence of dexmedetomidine upon sevoflurane end-expiratory concentration. Evaluation by bispectral index, suppression rate and electroencephalographic power spectral analysis. Revista brasileira de anestesiologia 20020401
N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20020301
Infusion of alpha-2-adrenergic agents into the paraventricular and arcuate nuclei of the hypothalamus in the Siberian hamster: opposing effects on basal prolactin. Neuroendocrinology 20020301
Dexmedetomidine may be effective, but is it safe? British journal of anaesthesia 20020301
Use of medetomidine for capture and restraint of cassowaries (Casuarius casuaris). Australian veterinary journal 20020301
Evaluation of medetomidine-ketamine anesthesia with atipamezole reversal in American alligators (Alligator mississippiensis). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301
Chemical restraint of fishers (Martes pennanti) with ketamine and medetomidine-ketamine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301
Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesthesiology 20020201
Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice. British journal of pharmacology 20020201
The use of alpha2-agonists during off-pump coronary artery bypass and the effects of hypothermia. Journal of cardiothoracic and vascular anesthesia 20020201
Some factors influencing the level of clinical sedation induced by medetomidine in rabbits. Journal of veterinary pharmacology and therapeutics 20020201
Initial experience with dexmedetomidine in paediatric-aged patients. Paediatric anaesthesia 20020201
alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics 20020101
Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. Anesthesiology 20020101
Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20020101
Postoperative pain control in cats: clinical trials with medetomidine and butorphanol. Veterinary surgery : VS 20020101
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop. BMC pharmacology 20020101
Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation. BMC pharmacology 20020101
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems. Neuroscience 20020101
Controlled hypotension in children: a critical review of available agents. Paediatric drugs 20020101
The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia. Neuroscience 20020101
The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals. Neuroscience 20020101
alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes. The Journal of pharmacology and experimental therapeutics 20011201
[Medetomidine-butorphanol combination anesthesia in the dog]. Schweizer Archiv fur Tierheilkunde 20011201
Dexmedetomidine decreases extracellular dopamine concentrations in the rat nucleus accumbens. Brain research 20011116
Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor. Progress in neuro-psychopharmacology & biological psychiatry 20011101
The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment. Anesthesia and analgesia 20011101
Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats. American journal of veterinary research 20011101
Cardiopulmonary effects of three different anaesthesia protocols in cats. The Veterinary quarterly 20011101
Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20011101
Dexmedetomidine: a real innovation or more of the same? British journal of anaesthesia 20011101
Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. British journal of anaesthesia 20011101
Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine. Journal of controlled release : official journal of the Controlled Release Society 20011019
Determinants of mortality after hypothermic circulatory arrest in a chronic porcine model. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20011001
The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S(+)-ketamine in rats. Anesthesia and analgesia 20011001
Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep. DTW. Deutsche tierarztliche Wochenschrift 20011001
Dexmedetomidine infusion and somatosensory evoked potentials. Journal of neurosurgical anesthesiology 20011001
Benzodiazepines in the intensive care unit. Critical care clinics 20011001
Use of propofol and other nonbenzodiazepine sedatives in the intensive care unit. Critical care clinics 20011001
New agents for sedation in the intensive care unit. Critical care clinics 20011001
Optimization of intraperitoneal injection anesthesia in mice: drugs, dosages, adverse effects, and anesthesia depth. Comparative medicine 20011001
Alpha(2) receptors and agonists in pain management. Current opinion in anaesthesiology 20011001
Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. Neuropharmacology 20010901
Cardiopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies. American journal of veterinary research 20010901
Effects of chronic tramadol on pre- and post-synaptic measures of monoamine function. Journal of psychopharmacology (Oxford, England) 20010901
Effects of medetomidine and buprenorphine administered for sedation in dogs. The Journal of small animal practice 20010901
Procedure for successful interspecific embryo transfer from mouflon (Ovis gmelini musimon) to Spanish Merino sheep (Ovis aries). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901
A study of presynaptic alpha2-autoreceptors in alpha2A/D-, alpha2B- and alpha2C-adrenoceptor-deficient mice. Naunyn-Schmiedeberg's archives of pharmacology 20010801
Dexmedetomidine. Current opinion in critical care 20010801
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain. The European journal of surgery = Acta chirurgica 20010801
Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia. American journal of veterinary research 20010701
Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors. Anesthesiology 20010701
Reversible immobilization of eurasian otters with a combination of ketamine and medetomidine. Journal of wildlife diseases 20010701
Use of medetomidine-zolazepam-tiletamine with and without atipamezole reversal to immobilize captive California sea lions. Journal of wildlife diseases 20010701
In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters. International journal of pharmaceutics 20010619
Anaesthesia of gemsbok (Oryx gazella) with a combination of A3080, medetomidine and ketamine. Journal of the South African Veterinary Association 20010601
Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. Journal of autonomic pharmacology 20010601
Cardiopulmonary assessment of medetomidine, ketamine, and butorphanol anesthesia in captive Thomson's gazelles (Gazella thomsoni). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010601
High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase. Analytical biochemistry 20010515
Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. Biochemical pharmacology 20010501
The use of dexmedetomidine infusion for awake craniotomy. Anesthesia and analgesia 20010501
The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil. Anaesthesia 20010501
Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans). Contemporary topics in laboratory animal science 20010501
Dexmedetomidine, a novel alpha 2-adrenergic agonist for short-term sedation in the intensive care unit. Connecticut medicine 20010501
Comparison of medetomidine and dexmedetomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010501
Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. British journal of anaesthesia 20010501
Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models. Life sciences 20010406
Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochemistry international 20010401
Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology 20010401
Acid-base status and blood gas arterial values in free-ranging sika deer hinds immobilized with medetomidine and ketamine. Journal of wildlife diseases 20010401
Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies. American journal of veterinary research 20010401
Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs. American journal of veterinary research 20010401
[Efficacy of oncologic surgery. Does anesthesia influence the postoperative outcome?]. Zentralblatt fur Chirurgie 20010401
Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes. Journal of medicinal chemistry 20010315
Minimal alveolar concentration of desflurane in combination with an infusion of medetomidine for the anaesthesia of ponies. The Veterinary record 20010303
Clinical evaluation of established optimal immobilizing doses of medetomidine-ketamine in captive reindeer (Rangifer tarandus tarandus). American journal of veterinary research 20010301
The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs. Veterinary ophthalmology 20010301
Anaesthesia of roan antelope (Hippotragus equinus) with a combination of A3080, medetomidine and ketamine. Journal of the South African Veterinary Association 20010301
Effect of dexmedetomidine on propofol requirements in healthy subjects. Journal of pharmaceutical sciences 20010201
Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice. British journal of pharmacology 20010201
Results of cystometry and urethral pressure profilometry in dogs sedated with medetomidine or xylazine. American journal of veterinary research 20010201
Use of medetomidine and ketamine for immobilization of free-ranging giraffes. Journal of the American Veterinary Medical Association 20010115
Effects of preemptive atropine administration on incidence of medetomidine-induced bradycardia in dogs. Journal of the American Veterinary Medical Association 20010101
Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. British journal of clinical pharmacology 20010101
Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer. American journal of veterinary research 20010101
Hematological and biochemical reference intervals for wild caught Eurasian otter from Spain. Journal of wildlife diseases 20010101
Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat. Journal of neural transmission (Vienna, Austria : 1996) 20010101
Calcification of the intervertebral discs and curvature of the radius and ulna: a radiographic survey of Finnish miniature dachshunds. Acta veterinaria Scandinavica 20010101
Anesthetic effects of ketamine or isoflurane induction prior to isoflurane anesthesia in medetomidine-premedicated dogs. Journal of the American Animal Hospital Association 20010101
The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate in dogs. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20010101
Noradrenergic regulation of hippocampal place cells. Hippocampus 20010101
Use of sedative medications in the intensive care unit. Seminars in respiratory and critical care medicine 20010101
Dexmedetomidine: a novel sedative-analgesic agent. Proceedings (Baylor University. Medical Center) 20010101
Anesthetic and cardiopulmonary effects of propofol in dogs premedicated with atropine, butorphanol, and medetomidine. Veterinary therapeutics : research in applied veterinary medicine 20010101
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. British journal of pharmacology 20000401
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 19991201
Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions. Biochimica et biophysica acta 19981119
Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors. European journal of pharmacology 19980821
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochemical pharmacology 19980401
Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in pharmacological sciences 19970601
Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 19970201
Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs. British journal of anaesthesia 19960901
Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology 19951101
Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology 19951101
Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy. Anesthesia and analgesia 19941001
Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. British journal of clinical pharmacology 19910201
Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology 19900501
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