Name: Name:2'-Deoxy-2'-fluorocytidine
Brand: Angene
SKU: AG0006OP
Rating: 90 (10 reviews)

Catalog Number:

AG0006OP

Chemical Name:

2'-Deoxy-2'-fluorocytidine

CAS Number:

10212-20-1

Molecular Formula:

C9H12FN3O4

Molecular Weight:

245.2077

MDL Number:

MFCD00057445

IUPAC Name:

4-amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI:

InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1

InChI Key:

NVZFZMCNALTPBY-XVFCMESISA-N

SMILES:

OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1ccc(nc1=O)N

UNII:

LCY080JPY9

Complexity:

386

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

245.081g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

245.21g/mol

Monoisotopic Mass:

245.081g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

108A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

-1.1

Title	Journal
In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections.	Antiviral research 20111101
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.	Bioorganic & medicinal chemistry letters 20100801
Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.	Rapid communications in mass spectrometry : RCM 20091001
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.	Bioorganic & medicinal chemistry letters 20070501
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.	Antiviral chemistry & chemotherapy 20060101
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.	Journal of medicinal chemistry 20050825
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.	Bioorganic & medicinal chemistry 20050301
Synthesis of some 2'-fluoro-2'-deoxy-3'-C-ethynyl and 3'-C-vinyl-beta-D-lyxofuranosyl nucleosides.	Nucleosides, nucleotides & nucleic acids 20050101
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.	Antimicrobial agents and chemotherapy 20040201
Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030225
A new class of Spiegelmers containing 2'-fluoro-nucleotides.	Nucleosides, nucleotides & nucleic acids 20030101
Quantification of 2'-fluoro-2'-deoxyuridine and 2'-fluoro-2'-deoxycytidine in DNA and RNA isolated from rats and woodchucks using LC/MS/MS.	Chemical research in toxicology 20020701
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.	Journal of medicinal chemistry 19790101