Home Other Building Blocks Butenafine HCl

Butenafine HCl

CAS No.:
101827-46-7
Catalog Number:
AG0005NO
Molecular Formula:
C23H28ClN
Molecular Weight:
353.9281
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%(HPLC)
In Stock USA
United States
$140
- +
5g
98%(HPLC)
In Stock USA
United States
$378
- +
Product Description
Catalog Number:
AG0005NO
Chemical Name:
Butenafine HCl
CAS Number:
101827-46-7
Molecular Formula:
C23H28ClN
Molecular Weight:
353.9281
MDL Number:
MFCD00917064
IUPAC Name:
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
InChI:
InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChI Key:
LJBSAUIFGPSHCN-UHFFFAOYSA-N
SMILES:
CN(Cc1cccc2c1cccc2)Cc1ccc(cc1)C(C)(C)C.Cl
UNII:
R8XA2029ZI
Properties
Complexity:
374  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
353.191g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
353.934g/mol
Monoisotopic Mass:
353.191g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. European journal of medicinal chemistry 20131001
Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115
A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations. Biomedical chromatography : BMC 20111001
Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study. Journal of chromatographic science 20110801
RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation. Journal of AOAC International 20110101
[Activity of butenafine against ocular pathogenic filamentous fungi in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20100101
Butenafine and superficial mycoses: current status. Expert opinion on drug metabolism & toxicology 20080701
An unprecedented rearrangement in collision-induced mass spectrometric fragmentation of protonated benzylamines. Journal of mass spectrometry : JMS 20060901
[The effect of propyl gallate on the activity of various antifungal drugs against filamentous fungi in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20060401
In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. Biological & pharmaceutical bulletin 20050801
Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. The Journal of dermatological treatment 20050101
Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. International journal of dermatology 20030901
Butenafine: an update of its use in superficial mycoses. Skin therapy letter 20020901
Experimental and conformational analyses of interactions between butenafine and lipids. Antimicrobial agents and chemotherapy 20011201
Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis). Journal of the Indian Medical Association 20010501
Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin). Mycoses 20010101
Azole antifungal agents related to naftifine and butenafine. Archiv der Pharmazie 20000601
Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert opinion on pharmacotherapy 20000301
Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis. International journal of dermatology 19980601
Butenafine. Drugs 19980301
Two mechanisms of butenafine action in Candida albicans. Antimicrobial agents and chemotherapy 19930401
[Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 19910201
Properties