Home Other Building Blocks 3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo-

3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo-

CAS No.:
1007-18-7
Catalog Number:
AG0002NM
Molecular Formula:
C7H8N2O2
Molecular Weight:
152.1506
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Product Description
Catalog Number:
AG0002NM
Chemical Name:
3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo-
CAS Number:
1007-18-7
Molecular Formula:
C7H8N2O2
Molecular Weight:
152.1506
MDL Number:
MFCD11174156
IUPAC Name:
N-methyl-6-oxo-1H-pyridine-3-carboxamide
InChI:
InChI=1S/C7H8N2O2/c1-8-7(11)5-2-3-6(10)9-4-5/h2-4H,1H3,(H,8,11)(H,9,10)
InChI Key:
NBUNJDAKVMXXEF-UHFFFAOYSA-N
SMILES:
CNC(=O)c1ccc(=O)[nH]c1
UNII:
C2M49S613F
Properties
Complexity:
253  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
152.059g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
152.153g/mol
Monoisotopic Mass:
152.059g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
58.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.8  
Literature
Title Journal
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Simultaneous quantification of niacin and its three main metabolites in human plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901
Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line. Acta biochimica Polonica 20110101
Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomedical chromatography : BMC 20101001
Distribution of purine nucleotides in uremic fluids and tissues. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100901
Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. Journal of proteome research 20100604
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Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption. Analytical chemistry 20100215
Are so-called uremic toxins always toxic? Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101
Nicotinamide metabolites accumulate in the tissues of uremic rats. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101
The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. Biopharmaceutics & drug disposition 20070901
Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation. International journal of clinical pharmacology and therapeutics 20070801
Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites. Journal of clinical pharmacology 20070601
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiological genomics 20070424
Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. Scandinavian journal of urology and nephrology 20070101
Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. Pediatric nephrology (Berlin, Germany) 20060601
Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. Drug metabolism and disposition: the biological fate of chemicals 20060201
The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma. Nucleosides, nucleotides & nucleic acids 20060101
The effect of N-methyl-2-pyridone-5-carboxamide--A nicotinamide catabolite on poly ADP-rybosylation and oxidative stress injury in endothelial cells. Nucleosides, nucleotides & nucleic acids 20050101
The age-related increase in N-methyl-2-pyridone-5-carboxamide (NAD catabolite) in human plasma. Molecular and cellular biochemistry 20041201
An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure. Nucleosides, nucleotides & nucleic acids 20041001
Disturbances of purine nucleotide metabolism in uremia. Seminars in nephrology 20040901
Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure. Clinica chimica acta; international journal of clinical chemistry 20030901
N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney international. Supplement 20030501
Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. Molecular and cellular biochemistry 20020201
The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production. The American journal of gastroenterology 20010401
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