Home Halogens 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene

13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene

CAS No.:
100643-71-8
Catalog Number:
AG0002K9
Molecular Formula:
C19H19ClN2
Molecular Weight:
310.8206
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$19
- +
5g
98%
In Stock USA
United States
$65
- +
10g
98%
In Stock USA
United States
$113
- +
25g
98%
In Stock USA
United States
$225
- +
Product Description
Catalog Number:
AG0002K9
Chemical Name:
13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene
CAS Number:
100643-71-8
Molecular Formula:
C19H19ClN2
Molecular Weight:
310.8206
MDL Number:
MFCD00871949
IUPAC Name:
13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
InChI:
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI Key:
JAUOIFJMECXRGI-UHFFFAOYSA-N
SMILES:
Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1
UNII:
FVF865388R
Properties
Complexity:
425  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
310.124g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
310.825g/mol
Monoisotopic Mass:
310.124g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
24.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.5  
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A sensitive spectrophotometric method for the determination of desloratadine in tablets. Journal of AOAC International 20070101
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[Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101
[The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101
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The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers. European journal of clinical pharmacology 20060601
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Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060601
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Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability. Journal of managed care pharmacy : JMCP 20060301
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Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL. Journal of pharmaceutical and biomedical analysis 20060224
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Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis. Allergy and asthma proceedings 20060101
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Predicting and establishing the clinical efficacy of a histamine h(1)-receptor antagonist : desloratadine, the model paradigm. Clinical drug investigation 20050101
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Homology modelling and binding site mapping of the human histamine H1 receptor. European journal of medicinal chemistry 20041101
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Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria. The Journal of allergy and clinical immunology 20040901
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Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040601
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Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude. Aviation, space, and environmental medicine 20040501
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Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401
Levocetirizine better protects than desloratadine in a nasal provocation with allergen. The Journal of allergy and clinical immunology 20040401
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High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs. Journal of pharmaceutical and biomedical analysis 20040310
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Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine. Managed care interface 20040201
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Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research. Current medical research and opinion 20040101
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Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan. Journal of managed care pharmacy : JMCP 20040101
Pharmacokinetics and bioequivalence study of a generic desloratadine tablet formulation in healthy male volunteers. Arzneimittel-Forschung 20040101
Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines. Allergy and asthma proceedings 20040101
The ARIA/EAACI criteria for antihistamines: an assessment of the efficacy, safety and pharmacology of desloratadine. Allergy 20040101
Reported case of severe hepatotoxicity likely due to fluconazole and not desloratadine. Acta haematologica 20040101
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Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase. Rapid communications in mass spectrometry : RCM 20040101
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Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin. British journal of clinical pharmacology 20031001
Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001
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A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001
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Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725
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Comparison of the effects of desloratadine 5-mg daily and placebo on nasal airflow and seasonal allergic rhinitis symptoms induced by grass pollen exposure. Allergy 20030601
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