Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory.

Behavioural brain research 20120615

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.

Journal of signal transduction 20120101

K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.

Frontiers in pharmacology 20120101

Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.

Journal of toxicology 20120101

Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels.

Nature communications 20120101

SK2 channels are neuroprotective for ischemia-induced neuronal cell death.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20111201

Calcium-activated potassium channel KCa3.1 in lung dendritic cell migration.

American journal of respiratory cell and molecular biology 20111101

Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.

Toxicology 20111028

Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.

Neuropharmacology 20110601

Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.

Molecular pharmacology 20110601

Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.

Biological psychiatry 20110401

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110301

Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide.

The Journal of pharmacology and experimental therapeutics 20110301

Use of intermediate/small conductance calcium-activated potassium-channel activator for endothelial protection.

The Journal of thoracic and cardiovascular surgery 20110201

Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

PloS one 20110101

An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis.

PloS one 20110101

The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.

PloS one 20110101

Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.

Circulation 20101102

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Small conductance calcium-activated potassium channels: from structure to function.

Progress in neurobiology 20100701

Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.

Neuron 20100311

In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.

Neuropharmacology 20100301

Expression of Ca2+ -activated K+ channels in human dermal fibroblasts and their roles in apoptosis.

Skin pharmacology and physiology 20100101

Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations.

Neuropharmacology 20100101

K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.

Respiratory research 20100101

Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium.

American journal of physiology. Gastrointestinal and liver physiology 20091101

Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment.

Molecular pharmacology 20090901

A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.

The Journal of pharmacology and experimental therapeutics 20090101

Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.

Journal of medicinal chemistry 20081211

SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.

Journal of neurophysiology 20081101

Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.

Cellular and molecular life sciences : CMLS 20081001

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.

European journal of immunology 20080901

Temporal processing across multiple topographic maps in the electrosensory system.

Journal of neurophysiology 20080801

IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells.

American journal of physiology. Cell physiology 20080601

Calcium-activated potassium currents differentially modulate respiratory rhythm generation.

The European journal of neuroscience 20080601

Openers of calcium-activated potassium channels and endothelium-dependent hyperpolarizations in the guinea pig carotid artery.

Naunyn-Schmiedeberg's archives of pharmacology 20080401

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

British journal of pharmacology 20070701

Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.

Journal of neurochemistry 20070601

Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.

European journal of immunology 20070601

Calcium and small-conductance calcium-activated potassium channels in gonadotropin-releasing hormone neurons before, during, and after puberty.

Endocrinology 20070501

Inhibition of intermediate-conductance Ca2+-activated K+ channel and cytoprotective properties of 4-piperidinomethyl-2-isopropyl-5-methylphenol.

The Journal of pharmacy and pharmacology 20070501

Ca2+ release-dependent hyperpolarizations modulate the firing pattern of juvenile GABA neurons in mouse substantia nigra pars reticulata in vitro.

The Journal of physiology 20061215

Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and bicarbonate secretion.

American journal of physiology. Gastrointestinal and liver physiology 20061201

Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells.

American journal of physiology. Lung cellular and molecular physiology 20061101

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.

Molecular pharmacology 20061101

Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery.

British journal of pharmacology 20061101

Exposure to sodium butyrate leads to functional downregulation of calcium-activated potassium channels in human airway epithelial cells.

Pflugers Archiv : European journal of physiology 20061101

Distinct K+ conductive pathways are required for Cl- and K+ secretion across distal colonic epithelium.

American journal of physiology. Cell physiology 20061001

In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.

European journal of pharmacology 20060928

SK Ca2+-activated K+ channel ligands alter the firing pattern of dopamine-containing neurons in vivo.

Neuroscience 20060630

Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats.

British journal of pharmacology 20060601

Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

European journal of pharmacology 20060524

Subtype-specific, bi-component inhibition of SK channels by low internal pH.

Biochemical and biophysical research communications 20060512

Impairment of PAR-2-mediated relaxation system in colonic smooth muscle after intestinal inflammation.

British journal of pharmacology 20060501

Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia.

Nature neuroscience 20060301

DCEBIO stimulates Cl- secretion in the mouse jejunum.

American journal of physiology. Cell physiology 20060101

Interactions of N-terminal and C-terminal parts of the small conductance Ca2+ activated K+ channel, hSK3.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

The Journal of biological chemistry 20051216

Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons.

Brain research 20051214

Ion transport regulated by protease-activated receptor 2 in human airway Calu-3 epithelia.

British journal of pharmacology 20051001

Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration.

British journal of pharmacology 20051001

1-Ethyl-2-benzimidazolinone (EBIO) suppresses epileptiform activity in in vitro hippocampus.

Neuropharmacology 20050901

Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.

Circulation research 20050819

Cl- secretory effects of EBIO in the rabbit conjunctival epithelium.

American journal of physiology. Cell physiology 20050701

Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model.

Journal of pharmacological sciences 20050701

Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050601

Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats.

Kidney international 20050601

A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050406

Genistein stimulates electrogenic Cl(-) secretion in mouse jejunum.

American journal of physiology. Cell physiology 20041201

Reduction of airway anion secretion via CFTR in sphingomyelin pathway.

Biochemical and biophysical research communications 20041112

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Biochimica et biophysica acta 20041011

A 'virtual gland' method for quantifying epithelial fluid secretion.

American journal of physiology. Lung cellular and molecular physiology 20041001

Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells.

The Journal of biological chemistry 20040910

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.

The Journal of allergy and clinical immunology 20040701

Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.

American journal of physiology. Lung cellular and molecular physiology 20040601

ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells.

American journal of respiratory cell and molecular biology 20040301

An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.

Molecular pharmacology 20040301

Inhibition of endothelium-dependent vasorelaxation by extracellular K(+): a novel controlling signal for vascular contractility.

American journal of physiology. Heart and circulatory physiology 20040101

Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.

BMC dermatology 20040101

Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension.

European journal of pharmacology 20031114

Role of endothelial intermediate conductance KCa channels in cerebral EDHF-mediated dilations.

American journal of physiology. Heart and circulatory physiology 20031001

Calcium activates SK channels in the intact human lens.

Investigative ophthalmology & visual science 20030901

Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030820

Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.

European journal of pharmacology 20030627

Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia.

Pediatric research 20030401

Inhibition of EDHF by two new combinations of K+-channel inhibitors in rat isolated mesenteric arteries.

British journal of pharmacology 20030301

Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation.

The Journal of biological chemistry 20030131

Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.

Brain research 20030103

SK4/IK1-like channels mediate TEA-insensitive, Ca2+-activated K+ currents in bovine parotid acinar cells.

American journal of physiology. Cell physiology 20030101

Expression and activity of potassium ion channels in human prostate cancer.

Cancer letters 20021201

Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF.

British journal of pharmacology 20021201

Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells.

Toxicology and applied pharmacology 20020915

Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo.

The Journal of physiology 20020801

Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.

British journal of pharmacology 20020801

Bisphenol A inhibits Cl(-) secretion by inhibition of basolateral K+ conductance in human airway epithelial cells.

The Journal of pharmacology and experimental therapeutics 20020701

Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line.

Brain research 20020607

Regulation of a calcium-sensitive K+ channel (cIK1) by protein kinase C.

The Journal of membrane biology 20020501

Characterization of an apamin-sensitive small-conductance Ca(2+)-activated K(+) channel in porcine coronary artery endothelium: relevance to EDHF.

British journal of pharmacology 20020301

Physiological role of calcium-activated potassium currents in the rat lateral amygdala.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.

The Journal of physiology 20020201

Activation of endothelial cell IK(Ca) with 1-ethyl-2-benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery.

British journal of pharmacology 20011201

Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.

American journal of physiology. Lung cellular and molecular physiology 20011101

Novel effects of minocycline on Ca(2+)-dependent Cl(-) secretion in human airway epithelial Calu-3 cells.

Toxicology and applied pharmacology 20011015

Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium.

Molecular pharmacology 20011001

Phenanthrolines--a new class of CFTR chloride channel openers.

British journal of pharmacology 20011001

Regulation of anion secretion by nitric oxide in human airway epithelial cells.

American journal of physiology. Lung cellular and molecular physiology 20010801

Comparison of effects of diabetes mellitus on an EDHF-dependent and an EDHF-independent artery.

American journal of physiology. Heart and circulatory physiology 20010701

Microelectrode and impedance analysis of anion secretion in Calu-3 cells.

JOP : Journal of the pancreas 20010701

EDHF is not K+ but may be due to spread of current from the endothelium in guinea pig arterioles.

American journal of physiology. Heart and circulatory physiology 20010601

Pharmacological modulation of SK3 channels.

Neuropharmacology 20010601

Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515

Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels.

The Journal of biological chemistry 20010330

NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion.

American journal of physiology. Cell physiology 20010301

Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.

The Journal of pharmacology and experimental therapeutics 20010301

Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.

British journal of pharmacology 20010201

Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.

The Journal of pharmacology and experimental therapeutics 20010201

Expression and biological significance of Ca2+-activated ion channels in human keratinocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

Characterisation of the rat SK4/IK1 K(+) channel.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101

EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.

Pflugers Archiv : European journal of physiology 20010101

Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.

American journal of physiology. Cell physiology 20000301

Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.

The American journal of physiology 19980901