3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
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Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. | Scientific reports 20140101 |
Differences in lercanidipine systemic exposure when administered according to labelling: in fasting state and 15 minutes before food intake. | European journal of clinical pharmacology 20120701 |
Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615 |
Polymorphism of the methylenetetrahydrofolate reductase gene C677T and its influence on the antihypertensive and vascular protective effects of short-term lercanidipine treatment. | Gene 20120601 |
[ACE inhibitor and calcium antagonist in fixed combination: effective protection for hypertensive patients at risk]. | MMW Fortschritte der Medizin 20120209 |
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism. | Bioorganic & medicinal chemistry letters 20120115 |
Blood pressure and metabolic effect of a combination of lercanidipine with different antihypertensive drugs in clinical practice. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101 |
Efficacy and safety of a fixed-dose combination of lercanidipine and enalapril in daily practice. A comparison of office, self-measured and ambulatory blood pressure. | Expert opinion on pharmacotherapy 20111201 |
Assay of lercanidipine hydrochloride in dosage forms using nucleophilic substitution reaction. | Acta pharmaceutica (Zagreb, Croatia) 20111201 |
Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. | Colloids and surfaces. B, Biointerfaces 20110901 |
Lercanidipine rescues hippocampus pyramidal neurons from mild ischemia-induced delayed neuronal death in SHRSP. | Cellular and molecular neurobiology 20110501 |
Lercanidipine-associated nocturia. | QJM : monthly journal of the Association of Physicians 20110501 |
[Fixed combination enalapril/lercanidipine in routine treatment: consistent RR reduction with kidney protection]. | MMW Fortschritte der Medizin 20110120 |
Management of lercanidipine overdose with hyperinsulinaemic euglycaemia therapy: case report. | Scandinavian journal of trauma, resuscitation and emergency medicine 20110101 |
Role of the fixed-dose combination lercanidipine-enalapril in renal protection. | Journal of nephrology 20110101 |
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study. | Bioorganic & medicinal chemistry 20101115 |
Comparison of changes of body water measured by using bioelectrical impedance analysis between lercanidipine and amlodipine therapy in hypertensive outpatients. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20101101 |
Determination of pK(a) values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures. | Talanta 20100915 |
Incidence and clinical course of lercanidipine-associated cloudy effluent in continuous ambulatory peritoneal dialysis. | Clinical nephrology 20100901 |
Drug synergism of antihypertensive action in combination of telmisartan with lercanidipine in spontaneous hypertensive rats. | Archives of pharmacal research 20100901 |
Hypertension may affect tooth-supporting alveolar bone quality: a study in rats. | Journal of periodontology 20100701 |
[First episode of atrial fibrillation]. | Revue medicale de Liege 20100401 |
Calcium channel blocker. | Clinical therapeutics 20100201 |
Superior palatability of crushed lercanidipine compared with amlodipine among children. | British journal of clinical pharmacology 20100201 |
Treatment of proteinuria with lercanidipine associated with renin-angiotensin axis-blocking drugs. | Renal failure 20100101 |
Efficacy and tolerability of the fixed lercanidipine-enalapril combination in the treatment of patients with essential hypertension. | Arzneimittel-Forschung 20100101 |
Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril. | Clinical drug investigation 20100101 |
Formulation and in vitro evaluation of buoyant controlled release lercanidipine lipospheres. | Journal of microencapsulation 20091101 |
Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension. | Hypertension (Dallas, Tex. : 1979) 20090801 |
The role of fixed-dose combinations in the management of hypertension: focus on lercanidipine-enalapril. | Expert opinion on pharmacotherapy 20090801 |
Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? | Expert opinion on drug metabolism & toxicology 20090801 |
Results of a meta-analysis comparing the tolerability of lercanidipine and other dihydropyridine calcium channel blockers. | Clinical therapeutics 20090801 |
Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups. | Singapore medical journal 20090501 |
Enantioselectivity in the pharmacokinetic interaction between fluvastatin and lercanidipine in healthy volunteers. | Journal of clinical pharmacology 20090201 |
Fixed-combination therapies in hypertension management: focus on enalapril/lercanidipine. | Expert review of cardiovascular therapy 20090201 |
Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling. | Pharmacological research 20090101 |
[Some aspects of the clinical use of lercamen (lercadipine)]. | Georgian medical news 20090101 |
Comparative effects of carvedilol and lercanidipine on ultrafiltration and solute transport in CAPD patients. | Renal failure 20090101 |
Lercanidipine decreases vascular matrix metalloproteinase-2 activity and protects against vascular dysfunction in diabetic rats. | European journal of pharmacology 20081203 |
Patient adherence and the choice of antihypertensive drugs: focus on lercanidipine. | Vascular health and risk management 20081201 |
The combined effect of calcium channel blocker Lercanidipine and antioxidants on low-grade systemic inflammation parameters in essential hypertension patients. | Minerva cardioangiologica 20081001 |
Lercanidipine reduces matrix metalloproteinase-2 activity and reverses vascular dysfunction in renovascular hypertensive rats. | European journal of pharmacology 20080904 |
Fixed combinations in the management of hypertension: perspectives on lercanidipine-enalapril. | Vascular health and risk management 20080801 |
High doses of lercanidipine are better tolerated than other dihydropyridines in hypertensive patients with metabolic syndrome: results from the TOLERANCE study. | International journal of clinical practice 20080501 |
Fixed-dose lercanidipine/enalapril for hypertension. | Drugs of today (Barcelona, Spain : 1998) 20080401 |
Development and evaluation of buccoadhesive controlled release tablets of lercanidipine. | AAPS PharmSciTech 20080301 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. | Journal of medicinal chemistry 20080124 |
Tolerability of high doses of lercanidipine versus high doses of other dihydropyridines in daily clinical practice: the TOLERANCE Study. | Cardiovascular therapeutics 20080101 |
Lercanidipine-induced chyloperitoneum in patients on peritoneal dialysis. | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20080101 |
Lercanidipine, enalapril and their combination in the treatment of elderly hypertensive patients: placebo-controlled, randomized, crossover study with four ABPM. | Journal of human hypertension 20071201 |
A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice. | Vascular health and risk management 20071201 |
Efficacy and tolerability of lercanidipine in patients with hypertension: results of a Phase IV study in general practice. | Expert opinion on pharmacotherapy 20071001 |
Effect of lercanidipine on kidney microanatomy in Cohen-Rosenthal diabetic hypertensive rats. | Journal of cardiovascular pharmacology and therapeutics 20070601 |
Lercanidipine in the treatment of hypertension. | The Annals of pharmacotherapy 20070301 |
Fixed-dose combination lercanidipine/enalapril. | Drugs 20070101 |
[The effect of calcium channel blocker lercanidipine on lowgrade inflammation parameters in essential hypertension patients]. | Harefuah 20061201 |
Assessment of cognitive function in patients with essential hypertension treated with lercanidipine. | Vascular health and risk management 20061201 |
Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. | International journal of clinical practice 20061101 |
Hypertension, possible vascular protection and lercanidipine. | Expert review of cardiovascular therapy 20061101 |
Cloudy dialysate due to lercanidipine. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061001 |
[Antihypertensive agents used as first line agents: beta-blockers under pressure]. | Revue medicale suisse 20060913 |
[Lercanidipine, a third generation calcium antagonist. Which advantages?]. | Revue medicale suisse 20060913 |
[Hypertensive patients can benefit from a new generation of calcium channel blockers. Lercanidipine: effective with few side effects]. | Revue medicale suisse 20060510 |
Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501 |
Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC-UV and LC-ESI-MS/MS. | Journal of pharmaceutical and biomedical analysis 20060411 |
Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters. | The Kaohsiung journal of medical sciences 20060401 |
Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. | Journal of hypertension 20060101 |
Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension. | Journal of cardiovascular pharmacology 20060101 |
Ultra-performance liquid chromatography/tandem mass spectrometry method for the determination of lercanidipine in human plasma. | Rapid communications in mass spectrometry : RCM 20060101 |
Effects of long-term lercanidipine or hydrochlorothiazide administration on hypertension-related vascular structural changes. | Blood pressure 20060101 |
Correlations of smoothness index and trough-to-peak ratio with left ventricular mass index changes induced by lercanidipine in hypertensive patients. A pilot trial. | Minerva medica 20051001 |
Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue. | Clinical and experimental pharmacology & physiology 20050901 |
Lercanidipine in hypertension. | Vascular health and risk management 20050901 |
[What chance is there that the patient will be treated!]. | La Revue de medecine interne 20050701 |
Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. | Life sciences 20050520 |
Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats. | Biological & pharmaceutical bulletin 20050501 |
[Lowering blood pressure with new calcium antagonists. High benefit by innovative mechanism of action]. | MMW Fortschritte der Medizin 20050203 |
[Also for problem cases; successful first line therapy]. | MMW Fortschritte der Medizin 20050203 |
[Drug information about lercanidipine. A new dihydropyridine calcium antagonist for the treatment of arterial hypertension]. | Ugeskrift for laeger 20050110 |
Lercanidipine in patients with chronic renal failure: the ZAFRA study. | Renal failure 20050101 |
Advantages of blood pressure optimization. | Advances in therapy 20050101 |
Enantioselective pharmacokinetics of lercanidipine in healthy volunteers. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225 |
In vitro inhibitory effect of lercanidipine on cholesterol accumulation and matrix metalloproteinases secretion by macrophages. | Journal of cardiovascular pharmacology 20041001 |
Effect of lercanidipine compared with ramipril on albumin excretion rate in hypertensive Type 2 diabetic patients with microalbuminuria: DIAL study (diabete, ipertensione, albuminuria, lercanidipina). | Diabetes, nutrition & metabolism 20041001 |
[Efficacy and acceptability of lercanidipine are not age dependent in patients with essential hypertension: the AGATE study]. | Annales de cardiologie et d'angeiologie 20040601 |
Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine. | British journal of pharmacology 20040501 |
Selective and rapid liquid chromatography-mass spectrometry method for the determination of lercanidipine in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425 |
[Lercanidipine in diabetic patients with renal failure]. | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101 |
A randomized, double-blind comparison of lercanidipine 10 and 20 mg in patients with stable effort angina: clinical evaluation of cardiac function by ambulatory ventricular scintigraphic monitoring. | American journal of therapeutics 20040101 |
Therapeutic profile of manidipine and lercanidipine in hypertensive patients. | Advances in therapy 20040101 |
Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031105 |
Lercanidipine vs lacidipine in isolated systolic hypertension. | Journal of human hypertension 20031101 |
Extractive spectrophotometric methods for determination of lercanidipine. | Die Pharmazie 20031101 |
Antioxidant effect of lercanidipine. | Hypertension (Dallas, Tex. : 1979) 20031001 |
Heterogeneous effect of calcium antagonists on leg oedema: a comparison of amlodipine versus lercanidipine in hypertensive patients. | Journal of hypertension 20031001 |
Biological variability of albumin excretion rate and albumin-to-creatinine ratio in hypertensive type 2 diabetic patients. | Clinical chemistry and laboratory medicine 20030901 |
[Most hypertensive patients need drug combination treatment. 'First line therapy is in second place']. | MMW Fortschritte der Medizin 20030821 |
Differential effects of lercanidipine and nifedipine GITS on plasma norepinephrine in chronic treatment of hypertension. | American journal of hypertension 20030701 |
[Therapy of hypertension is mostly combination therapy. Calcium antagonists are ideal partners]. | MMW Fortschritte der Medizin 20030626 |
Effect of treatment with lercanidipine on heart of Cohen-Rosenthal diabetic hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20030601 |
[Evaluation of lercanidipine in the general practice setting]. | Anales de medicina interna (Madrid, Spain : 1984) 20030601 |
[Evaluation of psychosomatic symptomatology in hypertensive patients treated with lercanidipine (LERCAPSICO study)]. | Anales de medicina interna (Madrid, Spain : 1984) 20030601 |
Quantification of leg oedema in postmenopausal hypertensive patients treated with lercanidipine or amlodipine. | Journal of hypertension 20030501 |
Improved tolerability of the dihydropyridine calcium-channel antagonist lercanidipine: the lercanidipine challenge trial. | Blood pressure. Supplement 20030501 |
Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension. | Hypertension (Dallas, Tex. : 1979) 20030401 |
Antioxidant activity of different dihydropyridines. | Biochemical and biophysical research communications 20030321 |
Effects of lercanidipine on coronary reactivity and myocardial remodeling in transition to heart failure in cardiomyopathic hamsters. | Acta pharmacologica Sinica 20030301 |
Short-versus long-term effects of different dihydropyridines on sympathetic and baroreflex function in hypertension. | Hypertension (Dallas, Tex. : 1979) 20030301 |
A selective HPLC method for determination of lercanidipine in tablets. | Journal of pharmaceutical and biomedical analysis 20030205 |
Emerging data on calcium-channel blockers: the COHORT study. | Clinical cardiology 20030201 |
[Depot calcium antagonist. General practice study confirms good tolerance]. | MMW Fortschritte der Medizin 20030130 |
Comparative effect of lercanidipine, felodipine, and nifedipine GITS on blood pressure and heart rate in patients with mild to moderate arterial hypertension: the Lercanidipine in Adults (LEAD) Study. | Journal of clinical hypertension (Greenwich, Conn.) 20030101 |
Comparative effects of lercanidipine, lacidipine, and nifedipine gastrointestinal therapeutic system on blood pressure and heart rate in elderly hypertensive patients: the ELderly and LErcanidipine (ELLE) study. | Archives of gerontology and geriatrics 20030101 |
Lercanidipine : a review of its efficacy in the management of hypertension. | Drugs 20030101 |
Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives. | American journal of hypertension 20021101 |
Losartan and lercanidipine attenuate low-density lipoprotein oxidation in patients with hypertension and type 2 diabetes mellitus: a randomized, prospective crossover study. | Clinical pharmacology and therapeutics 20020901 |
A randomised, double-blind, double-dummy comparison of the efficacy and tolerability of lercanidipine tablets and losartan tablets in patients with mild to moderate essential hypertension. | Journal of human hypertension 20020801 |
Lercanidipine in type II diabetic patients with mild to moderate arterial hypertension. | Journal of cardiovascular pharmacology 20020701 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Usefulness of lercanidipine, a new calcium antagonist, for systemic hypertension. | The American journal of cardiology 20020115 |
Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats. | Journal of cardiovascular pharmacology 20020101 |
Interaction potential of lercanidipine, a new vasoselective dihydropyridine calcium antagonist. | Arzneimittel-Forschung 20020101 |
Antihypertensive efficacy and tolerability of lercanidipine in daily clinical practice. The ELYPSE Study. Eficacia de Lercanidipino y su Perfil de Seguridad. | Blood pressure 20020101 |
A randomized, double-blind comparison of 10 and 20 mg lercanidipine in patients with stable effort angina: effects on myocardial ischemia and heart rate variability. | American journal of therapeutics 20020101 |
Neuroprotective effect of treatment with calcium antagonists on hypertensive retina. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101 |
Differential pulse voltammetric assay of lercanidipine in tablets. | Journal of AOAC International 20020101 |
Gender differences and antioxidant treatment affect aortic reactivity in short-term diabetic rats. | European journal of pharmacology 20011109 |
Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats. | Mechanisms of ageing and development 20011101 |
[New calcium antagonist. Therapy of hypertension becomes more tolerable]. | MMW Fortschritte der Medizin 20011004 |
Diabetics with hypertension not controlled with ACE inhibitors: alternate therapies. | Angiology 20010701 |
[Hypertension in type 2 diabetic patients. Calcium antagonist supports the left heart]. | MMW Fortschritte der Medizin 20010621 |
Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats. | Mechanisms of ageing and development 20010601 |
Oxygen-free radical decrease in hypertensive patients treated with lercanidipine. | International angiology : a journal of the International Union of Angiology 20010601 |
[Modern calcium channel blockade. Lowering blood pressure with added benefits]. | MMW Fortschritte der Medizin 20010208 |
Lercanidipine: a novel dihydropyridine calcium-channel blocker. | Heart disease (Hagerstown, Md.) 20010101 |
Lercanidipine: a review of its use in hypertension. | Drugs 20001101 |
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats. | The Journal of pharmacology and experimental therapeutics 20000901 |