SRT1720 xHydrochloride
| Title | Journal |
|---|---|
| SIRT1 exhibits antioxidative effects in HT22 cells induced by tert-butyl alcohol. | Environmental toxicology 20180201 |
| Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001 |
| Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. | Toxicology letters 20161215 |
| Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. | Cancer research 20160301 |
| Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. | Toxicology and applied pharmacology 20160115 |
| Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity. | Journal of cancer research and clinical oncology 20160101 |
| The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. | Arthritis & rheumatology (Hoboken, N.J.) 20150501 |
| Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase. | Prostaglandins & other lipid mediators 20150101 |
| Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts. | International journal of molecular sciences 20141001 |
| Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20140901 |
| Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. | Reproductive sciences (Thousand Oaks, Calif.) 20140601 |
| SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. | American journal of physiology. Lung cellular and molecular physiology 20140501 |
| Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase. | International journal of molecular medicine 20140401 |
| Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. | Gastroenterology 20140201 |
| Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling. | Archives of biochemistry and biophysics 20140115 |
| Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20131101 |
| Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma. | Respirology (Carlton, Vic.) 20130201 |
| Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. | The Journal of biological chemistry 20120601 |
| Are sirtuins viable targets for improving healthspan and lifespan? | Nature reviews. Drug discovery 20120601 |
| A patent review of sirtuin activators: an update. | Expert opinion on therapeutic patents 20120401 |
| Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. | British journal of haematology 20111201 |
| Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. | Reproductive toxicology (Elmsford, N.Y.) 20110701 |
| Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. | The Journal of endocrinology 20110301 |
| SIRT1 is a novel regulator of key pathways of human labor. | Biology of reproduction 20110101 |
| SRT1720 improves survival and healthspan of obese mice. | Scientific reports 20110101 |
| Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101101 |
| Biochemical effects of SIRT1 activators. | Biochimica et biophysica acta 20100801 |
| Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. | Genes & development 20100701 |
| SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. | The Journal of pharmacology and experimental therapeutics 20100501 |
| Sirt1 activation protects the mouse renal medulla from oxidative injury. | The Journal of clinical investigation 20100401 |
| SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. | The Journal of biological chemistry 20100312 |
| Metabolic engineering of resveratrol and other longevity boosting compounds. | BioFactors (Oxford, England) 20100101 |
| Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. | American journal of physiology. Endocrinology and metabolism 20091101 |
| Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. | Protein science : a publication of the Protein Society 20090301 |
| Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. | BMC systems biology 20090101 |
| A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. | Nature 20081113 |
| Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. | Cell metabolism 20081101 |
| Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. | Nature 20071129 |