Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy.

Chemical communications (Cambridge, England) 20120918

Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila.

Microbial pathogenesis 20120901

Molecular function and potential evolution of the biofilm-modulating blue light-signalling pathway of Escherichia coli.

Molecular microbiology 20120901

Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product.

Journal of structural and functional genomics 20120901

Structures of the PelD cyclic diguanylate effector involved in pellicle formation in Pseudomonas aeruginosa PAO1.

The Journal of biological chemistry 20120831

The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium.

Nature 20120830

Identification of ligand analogues that control c-di-GMP riboswitches.

ACS chemical biology 20120817

A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins.

Journal of proteomics 20120803

Inside the complex regulation of Pseudomonas aeruginosa chaperone usher systems.

Environmental microbiology 20120801

Crystallization studies of the murine c-di-GMP sensor protein STING.

Acta crystallographica. Section F, Structural biology and crystallization communications 20120801

'Life-style' control networks in Escherichia coli: signaling by the second messenger c-di-GMP.

Journal of biotechnology 20120731

Synthesis and characterization of a fluorescent analogue of cyclic di-GMP.

Biochemistry 20120710

Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa.

The Journal of biological chemistry 20120706

Sensing the messenger: the diverse ways that bacteria signal through c-di-GMP.

Protein science : a publication of the Protein Society 20120701

Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803.

Molecular microbiology 20120701

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.

Nature structural & molecular biology 20120701

Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding.

Immunity 20120629

Cyclic di-GMP sensing via the innate immune signaling protein STING.

Molecular cell 20120629

The structural basis for the sensing and binding of cyclic di-GMP by STING.

Nature structural & molecular biology 20120624

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.

Nature structural & molecular biology 20120624

Engineered allosteric ribozymes that sense the bacterial second messenger cyclic diguanosyl 5'-monophosphate.

Analytical chemistry 20120605

A full-length bifunctional protein involved in c-di-GMP turnover is required for long-term survival under nutrient starvation in Mycobacterium smegmatis.

Microbiology (Reading, England) 20120601

Vaccination of mice with recombinant bacille Calmette-Guérin harboring Rv1357c protects similarly to native BCG.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20120601

The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways.

PLoS pathogens 20120601

Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network.

Molecular cell 20120525

Allosteric tertiary interactions preorganize the c-di-GMP riboswitch and accelerate ligand binding.

ACS chemical biology 20120518

[Exogenous 3', 5'-cyclic diguanylic acid prevents caries formation in rats].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120501

Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT.

PLoS pathogens 20120501

You've come a long way: c-di-GMP signaling.

Current opinion in microbiology 20120401

The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus.

Molecular microbiology 20120401

Nitric oxide regulation of cyclic di-GMP synthesis and hydrolysis in Shewanella woodyi.

Biochemistry 20120313

Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins.

Molecular bioSystems 20120301

A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection.

Molecular bioSystems 20120301

One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

Current protocols in nucleic acid chemistry 20120301

Crystallization and preliminary X-ray diffraction characterization of the XccFimX(EAL)-c-di-GMP and XccFimX(EAL)-c-di-GMP-XccPilZ complexes from Xanthomonas campestris.

Acta crystallographica. Section F, Structural biology and crystallization communications 20120301

[Activity of cyclic diguanylate (c-di-GMP) in bacteria and the study of its derivatives].

Yao xue xue bao = Acta pharmaceutica Sinica 20120301

The extremophile Acidithiobacillus ferrooxidans possesses a c-di-GMP signalling pathway that could play a significant role during bioleaching of minerals.

Letters in applied microbiology 20120201

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa.

Journal of microbiological methods 20120201

Discrete cyclic di-GMP-dependent control of bacterial predation versus axenic growth in Bdellovibrio bacteriovorus.

PLoS pathogens 20120201

Why do microorganisms produce rhamnolipids?

World journal of microbiology & biotechnology 20120201

Dynamic energy landscapes of riboswitches help interpret conformational rearrangements and function.

PLoS computational biology 20120201

Oligomer formation of the bacterial second messenger c-di-GMP: reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations.

Journal of the American Chemical Society 20120118

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.

Bioorganic & medicinal chemistry letters 20120115

Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer.

Biochemistry 20120110

Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device.

Nature communications 20120103

Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli.

PLoS genetics 20120101

Transcriptome profiling of a curdlan-producing Agrobacterium reveals conserved regulatory mechanisms of exopolysaccharide biosynthesis.

Microbial cell factories 20120101

Global regulatory pathways and cross-talk control pseudomonas aeruginosa environmental lifestyle and virulence phenotype.

Current issues in molecular biology 20120101

Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus.

mBio 20120101

The pyrimidine nucleotide biosynthetic pathway modulates production of biofilm determinants in Escherichia coli.

PloS one 20120101

Genes that influence swarming motility and biofilm formation in Variovorax paradoxus EPS.

PloS one 20120101

A phylogenetic analysis of the globins in fungi.

PloS one 20120101

Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries.

PloS one 20120101

Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection.

PloS one 20120101

Quorum sensing modulates colony morphology through alkyl quinolones in Pseudomonas aeruginosa.

BMC microbiology 20120101

Transcriptional regulation of opaR, qrr2-4 and aphA by the master quorum-sensing regulator OpaR in Vibrio parahaemolyticus.

PloS one 20120101

Social Behaviours under Anaerobic Conditions in Pseudomonas aeruginosa.

International journal of microbiology 20120101

Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.

PloS one 20120101

When ribonucleases come into play in pathogens: a survey of gram-positive bacteria.

International journal of microbiology 20120101

Comparative genomics reveals adaptation by Alteromonas sp. SN2 to marine tidal-flat conditions: cold tolerance and aromatic hydrocarbon metabolism.

PloS one 20120101

Different evolutionary modifications as a guide to rewire two-component systems.

Bioinformatics and biology insights 20120101

Cellulose synthase complexes: composition and regulation.

Frontiers in plant science 20120101

Engineering microbial consortia to enhance biomining and bioremediation.

Frontiers in microbiology 20120101

A previously uncharacterized gene stm0551 plays a repressive role in the regulation of type 1 fimbriae in Salmonella enterica serotype Typhimurium.

BMC microbiology 20120101

Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae.

BMC microbiology 20120101

Enzymatically active and inactive phosphodiesterases and diguanylate cyclases are involved in regulation of Motility or sessility in Escherichia coli CFT073.

mBio 20120101

Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems.

Annual review of cell and developmental biology 20120101

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities.

Cellular immunology 20120101

Rational design of fluorescent biosensor for cyclic di-GMP.

Chembiochem : a European journal of chemical biology 20111216

N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels.

Microbiology (Reading, England) 20111201

The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling.

Environmental microbiology 20111201

The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site.

Acta crystallographica. Section D, Biological crystallography 20111201

Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium.

Marine drugs 20111201

Overlapping and unique contributions of two conserved polysaccharide loci in governing distinct survival phenotypes in Vibrio vulnificus.

Environmental microbiology 20111101

Mechanism for gene control by a natural allosteric group I ribozyme.

RNA (New York, N.Y.) 20111101

A multi-repeat adhesin of the phytopathogen, Pectobacterium atrosepticum, is secreted by a Type I pathway and is subject to complex regulation involving a non-canonical diguanylate cyclase.

Molecular microbiology 20111101

Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation.

Molecular microbiology 20111101

Synthesis and characterization of C8 analogs of c-di-GMP.

Nucleosides, nucleotides & nucleic acids 20111101

STING is a direct innate immune sensor of cyclic di-GMP.

Nature 20111027

Differential analogue binding by two classes of c-di-GMP riboswitches.

Journal of the American Chemical Society 20111005

Large-scale production of the immunomodulator c-di-GMP from GMP and ATP by an enzymatic cascade.

Applied biochemistry and biotechnology 20111001

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia.

Molecular microbiology 20111001

Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms.

PLoS pathogens 20111001

The atypical two-component sensor kinase Lpl0330 from Legionella pneumophila controls the bifunctional diguanylate cyclase-phosphodiesterase Lpl0329 to modulate bis-(3'-5')-cyclic dimeric GMP synthesis.

The Journal of biological chemistry 20110909

c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment.

International immunopharmacology 20110901

Modulation of Pseudomonas aeruginosa surface-associated group behaviors by individual amino acids through c-di-GMP signaling.

Research in microbiology 20110901

c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress.

PLoS pathogens 20110901

Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.

Molecular cell 20110819

The bacterial second messenger c-di-GMP: mechanisms of signalling.

Cellular microbiology 20110801

MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression.

PLoS pathogens 20110801

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice.

Vaccine 20110712

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes.

Molecular microbiology 20110701

Cyclic diguanylate turnover mediated by the sole GGDEF/EAL response regulator in Pseudomonas putida: its role in the rhizosphere and an analysis of its target processes.

Environmental microbiology 20110701

Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.

PLoS pathogens 20110701

Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

Journal of the American Chemical Society 20110622

Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks.

PLoS pathogens 20110601

Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila.

Microbial pathogenesis 20110501

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.

Chemical communications (Cambridge, England) 20110428

Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout.

The Journal of biological chemistry 20110422

Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing.

Journal of molecular biology 20110415

Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule.

Journal of the American Chemical Society 20110406

GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli.

Applied microbiology and biotechnology 20110401

Interactions of the c-di-GMP riboswitch with its second messenger ligand.

Biochemical Society transactions 20110401

Engineering a novel c-di-GMP-binding protein for biofilm dispersal.

Environmental microbiology 20110301

Two-component regulatory systems in Pseudomonas aeruginosa: an intricate network mediating fimbrial and efflux pump gene expression.

Molecular microbiology 20110301

c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases.

PLoS genetics 20110301

cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!

Molecular microbiology 20110201

Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate.

Protein science : a publication of the Protein Society 20110201

A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage.

PLoS biology 20110201

Biofilm adherence and detachment pathway elucidated.

PLoS biology 20110201

Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis.

PLoS biology 20110201

Binding of cyclic diguanylate in the non-catalytic EAL domain of FimX induces a long-range conformational change.

The Journal of biological chemistry 20110128

Efficient enzymatic production of the bacterial second messenger c-di-GMP by the diguanylate cyclase YdeH from E. coli.

Applied biochemistry and biotechnology 20110101

Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides.

The Journal of pharmacology and experimental therapeutics 20110101

Surface sensing in Vibrio parahaemolyticus triggers a programme of gene expression that promotes colonization and virulence.

Molecular microbiology 20110101

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis.

Molecular microbiology 20110101

Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.

mBio 20110101

Biofilm development on Caenorhabditis elegans by Yersinia is facilitated by quorum sensing-dependent repression of type III secretion.

PLoS pathogens 20110101

FimL regulates cAMP synthesis in Pseudomonas aeruginosa.

PloS one 20110101

Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms.

PLoS genetics 20110101

iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis.

BMC bioinformatics 20110101

Delicate conformational changes of a protein in the CRP family lead to dramatic functional changes via binding of an alternate secondary messenger molecule.

Virulence 20110101

Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions.

PloS one 20110101

Comparative genomics reveals diversity among xanthomonads infecting tomato and pepper.

BMC genomics 20110101

Differential control of Yersinia pestis biofilm formation in vitro and in the flea vector by two c-di-GMP diguanylate cyclases.

PloS one 20110101

Pseudomonas aeruginosa: resistance to the max.

Frontiers in microbiology 20110101

Genome-wide mutagenesis of Xanthomonas axonopodis pv. citri reveals novel genetic determinants and regulation mechanisms of biofilm formation.

PloS one 20110101

A novel tetrameric PilZ domain structure from xanthomonads.

PloS one 20110101

Gene regulation in Borrelia burgdorferi.

Annual review of microbiology 20110101

Comparative analyses imply that the enigmatic Sigma factor 54 is a central controller of the bacterial exterior.

BMC genomics 20110101

CrdS and CrdA comprise a two-component system that is cooperatively regulated by the Che3 chemosensory system in Myxococcus xanthus.

mBio 20110101

Small Regulatory RNA and Legionella pneumophila.

Frontiers in microbiology 20110101

The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life.

PloS one 20110101

An α/β hydrolase and associated Per-ARNT-Sim domain comprise a bipartite sensing module coupled with diverse output domains.

PloS one 20110101

The structure of an unconventional HD-GYP protein from Bdellovibrio reveals the roles of conserved residues in this class of cyclic-di-GMP phosphodiesterases.

mBio 20110101

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl.

Frontiers in microbiology 20110101

Contribution of TAT system translocated PhoX to Campylobacter jejuni phosphate metabolism and resilience to environmental stresses.

PloS one 20110101

Escherichia coli BdcA controls biofilm dispersal in Pseudomonas aeruginosa and Rhizobium meliloti.

BMC research notes 20110101

Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP.

PloS one 20110101

Modulation of metabolism and switching to biofilm prevail over exopolysaccharide production in the response of Rhizobium alamii to cadmium.

PloS one 20110101

Complex c-di-GMP signaling networks mediate transition between virulence properties and biofilm formation in Salmonella enterica serovar Typhimurium.

PloS one 20110101

Characterization of pellicle inhibition in Gluconacetobacter xylinus 53582 by a small molecule, pellicin, identified by a chemical genetics screen.

PloS one 20110101

Small protein-mediated quorum sensing in a Gram-negative bacterium.

PloS one 20110101

Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa.

PloS one 20110101

Biochemical and physiological characterization of a BLUF protein-EAL protein complex involved in blue light-dependent degradation of cyclic diguanylate in the purple bacterium Rhodopseudomonas palustris.

Biochemistry 20101221

Important roles of Tyr43 at the putative heme distal side in the oxygen recognition and stability of the Fe(II)-O2 complex of YddV, a globin-coupled heme-based oxygen sensor diguanylate cyclase.

Biochemistry 20101214

The EpsE flagellar clutch is bifunctional and synergizes with EPS biosynthesis to promote Bacillus subtilis biofilm formation.

PLoS genetics 20101201

Cyclic-di-GMP reaches out into the bacterial RNA world.

Science signaling 20101123

The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon.

Microbiology (Reading, England) 20101001

Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmA.

Molecular microbiology 20101001

Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth.

Molecular microbiology 20101001

Structural insight into the mechanism of c-di-GMP hydrolysis by EAL domain phosphodiesterases.

Journal of molecular biology 20100924

Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase.

Bioorganic & medicinal chemistry 20100915

Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis.

Microbiology (Reading, England) 20100901

Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch .

Biochemistry 20100831

An allosteric self-splicing ribozyme triggered by a bacterial second messenger.

Science (New York, N.Y.) 20100813

An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal.

FEMS immunology and medical microbiology 20100801

The yddV-dos operon controls biofilm formation through the regulation of genes encoding curli fibers' subunits in aerobically growing Escherichia coli.

FEMS immunology and medical microbiology 20100801

3',5'-Cyclic diguanylic acid: a small nucleotide that makes big impacts.

Chemical Society reviews 20100801

Genetic analysis of two phosphodiesterases reveals cyclic diguanylate regulation of virulence factors in Dickeya dadantii.

Molecular microbiology 20100801

Vaccine development in Staphylococcus aureus: taking the biofilm phenotype into consideration.

FEMS immunology and medical microbiology 20100801

One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues.

Organic letters 20100716

Biofilm formation is not required for early-phase transmission of Yersinia pestis.

Microbiology (Reading, England) 20100701

GGDEF and EAL proteins play different roles in the control of Sinorhizobium meliloti growth, motility, exopolysaccharide production, and competitive nodulation on host alfalfa.

Acta biochimica et biophysica Sinica 20100615

Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division.

Science (New York, N.Y.) 20100604

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate.

Journal of microbiological methods 20100601

A post-translational, c-di-GMP-dependent mechanism regulating flagellar motility.

Molecular microbiology 20100601

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules.

Future medicinal chemistry 20100601

Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by Pilz domain proteins.

Journal of molecular biology 20100423

The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant.

Vaccine 20100419

The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a 'backstop brake' mechanism.

Molecular cell 20100409

Genome-wide screening of genes whose enhanced expression affects glycogen accumulation in Escherichia coli.

DNA research : an international journal for rapid publication of reports on genes and genomes 20100401

Genomic structure of an economically important cyanobacterium, Arthrospira (Spirulina) platensis NIES-39.

DNA research : an international journal for rapid publication of reports on genes and genomes 20100401

Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi.

FEMS immunology and medical microbiology 20100301

YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa.

PLoS pathogens 20100301

The effect of c-di-GMP (3'-5'-cyclic diguanylic acid) on the biofilm formation and adherence of Streptococcus mutans.

Microbiological research 20100227

The cAMP receptor-like protein CLP is a novel c-di-GMP receptor linking cell-cell signaling to virulence gene expression in Xanthomonas campestris.

Journal of molecular biology 20100226

Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.

Science (New York, N.Y.) 20100212

Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms.

Molecular microbiology 20100201

Beyond antibiotic resistance: integrating conjugative elements of the SXT/R391 family that encode novel diguanylate cyclases participate to c-di-GMP signalling in Vibrio cholerae.

Environmental microbiology 20100201

Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium.

Environmental microbiology 20100201

Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix.

Molecular microbiology 20100201

Structure, function, and evolution of the Thiomonas spp. genome.

PLoS genetics 20100201

Cyclic di-GMP signalling controls virulence properties of Salmonella enterica serovar Typhimurium at the mucosal lining.

Environmental microbiology 20100101

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors.

Applied microbiology and biotechnology 20100101

YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity.

The Journal of biological chemistry 20100101

A blue light-inducible phosphodiesterase activity in the cyanobacterium Synechococcus elongatus.

Photochemistry and photobiology 20100101

A framework for classification of prokaryotic protein kinases.

PloS one 20100101

Tobramycin at subinhibitory concentration inhibits the RhlI/R quorum sensing system in a Pseudomonas aeruginosa environmental isolate.

BMC infectious diseases 20100101

Identification of novel pathogenicity loci in Clostridium perfringens strains that cause avian necrotic enteritis.

PloS one 20100101

Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production.

BMC microbiology 20100101

A global metabolic shift is linked to Salmonella multicellular development.

PloS one 20100101

Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases.

mBio 20100101

TSCC: Two-Stage Combinatorial Clustering for virtual screening using protein-ligand interactions and physicochemical features.

BMC genomics 20100101

Identification, activity and disulfide connectivity of C-di-GMP regulating proteins in Mycobacterium tuberculosis.

PloS one 20100101

A novel C-di-GMP effector linking intracellular virulence regulon to quorum sensing and hypoxia sensing.

Virulence 20100101

SiaA and SiaD are essential for inducing autoaggregation as a specific response to detergent stress in Pseudomonas aeruginosa.

Environmental microbiology 20091201

Structural basis of ligand binding by a c-di-GMP riboswitch.

Nature structural & molecular biology 20091201

Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch.

Nature structural & molecular biology 20091201

Mobile antibiotic resistance encoding elements promote their own diversity.

PLoS genetics 20091201

Comparative ICE genomics: insights into the evolution of the SXT/R391 family of ICEs.

PLoS genetics 20091201

Effect of cyclic bis(3'-5')diguanylic acid and its analogs on bacterial biofilm formation.

FEMS microbiology letters 20091201

A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum.

Biochemistry 20091103

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila.

PLoS pathogens 20091101

A novel signaling network essential for regulating Pseudomonas aeruginosa biofilm development.

PLoS pathogens 20091101

Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR.

Journal of molecular biology 20091030

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.

Biochemistry 20091020

Structural and mechanistic determinants of c-di-GMP signalling.

Nature reviews. Microbiology 20091001

Crystallization and preliminary X-ray diffraction characterization of an essential protein from Xanthomonas campestris that contains a noncanonical PilZ signature motif yet is critical for pathogenicity.

Acta crystallographica. Section F, Structural biology and crystallization communications 20091001

Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.

Structure (London, England : 1993) 20090812

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection.

Vaccine 20090730

Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase.

Analytical biochemistry 20090615

Phenotypic variation in the Pseudomonas fluorescens clinical strain MFN1032.

Research in microbiology 20090601

Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.

Molecular microbiology 20090601

Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).

PLoS pathogens 20090601

Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains.

The Journal of biological chemistry 20090508

XC1028 from Xanthomonas campestris adopts a PilZ domain-like structure without a c-di-GMP switch.

Proteins 20090501

Globins synthesize the second messenger bis-(3'-5')-cyclic diguanosine monophosphate in bacteria.

Journal of molecular biology 20090501

BcsQ is an essential component of the Escherichia coli cellulose biosynthesis apparatus that localizes at the bacterial cell pole.

Molecular microbiology 20090501

Thiophosphate analogs of c-di-GMP: impact on polymorphism.

Nucleosides, nucleotides & nucleic acids 20090501

Principles of c-di-GMP signalling in bacteria.

Nature reviews. Microbiology 20090401

Bacterial nucleotide-based second messengers.

Current opinion in microbiology 20090401

Regulation of c-di-GMP metabolism in biofilms.

Future microbiology 20090401

Quantitative determination of cyclic diguanosine monophosphate concentrations in nucleotide extracts of bacteria by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

Analytical biochemistry 20090301

Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions.

Molecular microbiology 20090301

Vibrio biofilms: so much the same yet so different.

Trends in microbiology 20090301

The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli.

Genes & development 20090215

Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.

Genes & development 20090101

The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.

PloS one 20090101

Systems level analysis of two-component signal transduction systems in Erwinia amylovora: role in virulence, regulation of amylovoran biosynthesis and swarming motility.

BMC genomics 20090101

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BMC genomics 20090101

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PloS one 20090101

Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches.

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Molecular microbiology 20081001

The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins.

Molecular microbiology 20081001

Cyclic di-GMP: a second messenger required for long-term survival, but not for biofilm formation, in Mycobacterium smegmatis.

Microbiology (Reading, England) 20081001

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Genes & development 20080901

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Science signaling 20080819

Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor.

Molecular microbiology 20080701

Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice.

PLoS genetics 20080701

Effect of PEL exopolysaccharide on the wspF mutant phenotypes in Pseudomonas aeruginosa PA14.

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PLoS biology 20080301

Structural insight into a biofilm signaling molecule.

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Comparative analysis of the Photorhabdus luminescens and the Yersinia enterocolitica genomes: uncovering candidate genes involved in insect pathogenicity.

BMC genomics 20080101

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PloS one 20080101

Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1.

Genome biology 20080101

The structural basis of cyclic diguanylate signal transduction by PilZ domains.

The EMBO journal 20071212

Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.

Molecular microbiology 20071201

The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway.

The Journal of biological chemistry 20071116

Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization.

The Journal of biological chemistry 20071005

Pseudomonas aeruginosa cupA-encoded fimbriae expression is regulated by a GGDEF and EAL domain-dependent modulation of the intracellular level of cyclic diguanylate.

Environmental microbiology 20071001

Detergent-induced cell aggregation in subpopulations of Pseudomonas aeruginosa as a preadaptive survival strategy.

Environmental microbiology 20070901

A cyclic-di-GMP receptor required for bacterial exopolysaccharide production.

Molecular microbiology 20070901

A comprehensive genetic characterization of bacterial motility.

PLoS genetics 20070901

The role of c-di-GMP signaling in an Aeromonas veronii biovar sobria strain.

FEMS microbiology letters 20070801

The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa.

Molecular microbiology 20070801

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Structure (London, England : 1993) 20070801

PilZ domain proteins bind cyclic diguanylate and regulate diverse processes in Vibrio cholerae.

The Journal of biological chemistry 20070427

Bacterial c-di-GMP is an immunostimulatory molecule.

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NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein.

Proteins 20070201

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Current opinion in microbiology 20070201

Smooth to rugose phase variation in Vibrio cholerae can be mediated by a single nucleotide change that targets c-di-GMP signalling pathway.

Molecular microbiology 20070201

Phosphate-dependent modulation of c-di-GMP levels regulates Pseudomonas fluorescens Pf0-1 biofilm formation by controlling secretion of the adhesin LapA.

Molecular microbiology 20070201

Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii.

Microbial cell factories 20070101

Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.

Annual review of microbiology 20070101

Identification of sensory and signal-transducing domains in two-component signaling systems.

Methods in enzymology 20070101

Genomic analysis reveals the major driving forces of bacterial life in the rhizosphere.

Genome biology 20070101

Regulation of biofilm formation in Yersinia pestis.

Advances in experimental medicine and biology 20070101

The complete genome sequence and analysis of the epsilonproteobacterium Arcobacter butzleri.

PloS one 20070101

An unorthodox bacteriophytochrome from Rhodobacter sphaeroides involved in turnover of the second messenger c-di-GMP.

The Journal of biological chemistry 20061117

Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli.

Molecular microbiology 20061101

Allosteric control of cyclic di-GMP signaling.

The Journal of biological chemistry 20061020

The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria.

The Journal of biological chemistry 20061013

Polymorphism of the signaling molecule c-di-GMP.

Journal of the American Chemical Society 20060531

Hierarchical involvement of various GGDEF domain proteins in rdar morphotype development of Salmonella enterica serovar Typhimurium.

Molecular microbiology 20060501

Cyclic di-GMP as a second messenger.

Current opinion in microbiology 20060401

Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid.

The Journal of biological chemistry 20060324

Bacterial birth scar proteins mark future flagellum assembly site.

Cell 20060310

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Bioinformatics (Oxford, England) 20060101

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Annual review of genetics 20060101

The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase.

The Journal of biological chemistry 20050930

Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP.

The Journal of biological chemistry 20050902

Aminoglycoside antibiotics induce bacterial biofilm formation.

Nature 20050825

C-di-GMP: the dawning of a novel bacterial signalling system.

Molecular microbiology 20050801

The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in Yersinia pestis.

FEMS microbiology letters 20050615

Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae.

Cellular and molecular life sciences : CMLS 20050601

Characterization of starvation-induced dispersion in Pseudomonas putida biofilms.

Environmental microbiology 20050601

3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation.

Biochemical and biophysical research communications 20050401

[Proteins with GGDEF and EAL domains: their role in bacterial metabolism].

Revista latinoamericana de microbiologia 20050101

Chemical behavior of bis(3'-5')diguanylic acid in aqueous solutions.

Nucleic acids symposium series (2004) 20050101

c-di-GMP displays a monovalent metal ion-dependent polymorphism.

Journal of the American Chemical Society 20041229

Features of bacterial cellulose synthesis in a mutant generated by disruption of the diguanylate cyclase 1 gene of Acetobacter xylinum BPR 2001.

Applied microbiology and biotechnology 20040801

Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation.

Molecular microbiology 20040801

Cyclic di-GMP as a bacterial second messenger.

Microbiology (Reading, England) 20040801

GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility.

Molecular microbiology 20040801

Identification of genes involved in the switch between the smooth and rugose phenotypes of Vibrio cholerae.

FEMS microbiology letters 20031010