Home Other Building Blocks Mangafodipir trisodium

Mangafodipir trisodium

CAS No.:
140678-14-4
Catalog Number:
AG009CIZ
Molecular Formula:
C22H27MnN4Na3O14P2
Molecular Weight:
757.3231
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$223
- +
5mg
99%
1 week
United States
$543
- +
10mg
99%
1 week
United States
$821
- +
Product Description
Catalog Number:
AG009CIZ
Chemical Name:
Mangafodipir trisodium
CAS Number:
140678-14-4
Molecular Formula:
C22H27MnN4Na3O14P2
Molecular Weight:
757.3231
MDL Number:
MFCD01939723
IUPAC Name:
trisodium;2-[2-[carboxylatomethyl-[[2-methyl-3-oxido-5-(phosphonatooxymethyl)pyridin-4-yl]methyl]amino]ethyl-[[2-methyl-3-oxido-5-(phosphonatooxymethyl)pyridin-4-yl]methyl]amino]acetate;hydron;manganese(2+)
InChI:
InChI=1S/C22H32N4O14P2.Mn.3Na/c1-13-21(31)17(15(5-23-13)11-39-41(33,34)35)7-25(9-19(27)28)3-4-26(10-20(29)30)8-18-16(12-40-42(36,37)38)6-24-14(2)22(18)32;;;;/h5-6,31-32H,3-4,7-12H2,1-2H3,(H,27,28)(H,29,30)(H2,33,34,35)(H2,36,37,38);;;;/q;+2;3*+1/p-5
InChI Key:
BENFPBJLMUIGGD-UHFFFAOYSA-I
SMILES:
O=C1[O-][Mn+2]2345[N](C1)(CC[N]5(CC(=O)[O-]2)Cc1c([O-]4)c(C)ncc1COP(=O)(O)O)Cc1c([O-]3)c(C)ncc1COP(=O)(O)[O-].[Na+].[Na+].[Na+]
Properties
Complexity:
873  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
8  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
757.007g/mol
Formal Charge:
0
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
757.327g/mol
Monoisotopic Mass:
757.007g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
304A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers. The British journal of radiology 20120901
Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI? European journal of radiology 20110801
Mangafodipir protects against hepatic ischemia-reperfusion injury in mice. PloS one 20110101
Magnetic resonance cholangiography with mangafodipir trisodium in Caroli's disease with pancreas involvement. JOP : Journal of the pancreas 20100906
Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways. European journal of pharmacology 20100825
In vitro neurotoxicity of magnetic resonance imaging (MRI) contrast agents: influence of the molecular structure and paramagnetic ion. Toxicology in vitro : an international journal published in association with BIBRA 20100801
Toward clinical application of manganese-enhanced MRI of retinal function. Brain research bulletin 20100215
Secretin-stimulated multi-detector CT versus mangafodipir trisodium-enhanced MR imaging plus MRCP in characterization of non-metastatic solid pancreatic lesions. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20091101
Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. Therapeutic drug monitoring 20091001
Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics : a review publication of the Radiological Society of North America, Inc 20091001
Tumor models and specific contrast agents for small animal imaging in oncology. Methods (San Diego, Calif.) 20090601
Detection of neuroendocrine liver metastases with MnDPDP-enhanced MRI. Neuroendocrinology 20090101
Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report. Acta oncologica (Stockholm, Sweden) 20090101
[Imaging of the postoperative biliary tract]. Journal de radiologie 20090101
Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20090101
Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics. Clinical radiology 20081101
The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRI. European journal of nuclear medicine and molecular imaging 20080701
Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination. European radiology 20080501
Axon tracing in the adult rat optic nerve and tract after intravitreal injection of MnDPDP using a semiautomatic segmentation technique. Journal of magnetic resonance imaging : JMRI 20080101
[Value of MRCP with Mangafodipir Trisodium (Teslascan) injection in the diagnosis and management of bile leaks]. Journal de radiologie 20071201
Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI. Acta bio-medica : Atenei Parmensis 20071201
Manganese dipyridoxyl-diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction. Journal of magnetic resonance imaging : JMRI 20070901
Re: diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma. Clinical radiology 20070801
Contrast enhanced cartilage imaging: Comparison of ionic and non-ionic contrast agents. European journal of radiology 20070701
[New possibilities to study biliary tree and gallbladder: functional magnetic resonance cholangiography contrast-enhanced with mangafodipir trisodium (Mn DPDP)]. Journal de radiologie 20070401
Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium. AJR. American journal of roentgenology 20070201
An apparent unidirectional influx constant for manganese as a measure of myocardial calcium channel activity. Journal of magnetic resonance imaging : JMRI 20061101
Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging. European journal of radiology 20061001
Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20060901
Imaging liver metastases: review and update. European journal of radiology 20060501
Mangafodipir trisodium-enhanced MR imaging of pancreatic disease. European radiology 20060501
Mangafodipir trisodium-enhanced MRI for the detection and characterization of focal hepatic lesions: is delayed imaging useful? Journal of magnetic resonance imaging : JMRI 20060501
Diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma. Clinical radiology 20060401
Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients. AJR. American journal of roentgenology 20060401
Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions. World journal of gastroenterology 20060314
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity. Journal of the National Cancer Institute 20060215
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. Journal of the National Cancer Institute 20060215
The magnetic resonance imaging contrast agent mangafodipir exerts antitumor activity via a previously described superoxide dismutase mimetic activity. Cancer research 20060101
[Mangafodipir trisodium-enhanced magnetic resonance cholangiography for detection of bile leaks]. Journal de radiologie 20060101
[MR and biliary tract]. Ugeskrift for laeger 20050829
Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET. AJR. American journal of roentgenology 20050701
MR cholangiography with manganese dipyridoxyl diphosphate in the evaluation of biliary-enteric anastomoses: preliminary experience. AJR. American journal of roentgenology 20050501
Functional MR cholangiography: diagnosis of functional abnormalities of the gallbladder and biliary tree. AJR. American journal of roentgenology 20050501
On the AJR viewbox. Intrapancreatic accessory spleen: diagnosis with RES-specific contrast-enhanced MRI. AJR. American journal of roentgenology 20050501
Detection of liver metastases from gastrointestinal cancer: comparision of high resolution MnDPDP enhanced MRI and FDG-PET. Academic radiology 20050501
Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation. Radiology 20050401
Double gallbladder diagnosed on contrast-enhanced MR cholangiography with mangafodipir trisodium. AJR. American journal of roentgenology 20050301
Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination. Investigative radiology 20050101
Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging. Investigative radiology 20050101
Bile duct leaks after laparoscopic cholecystectomy: value of contrast-enhanced MRCP. Abdominal imaging 20050101
Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging. Journal of computer assisted tomography 20050101
Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 20050101
Gadobenate dimeglumine as an intrabiliary contrast agent: comparison with mangafodipir trisodium with respect to non-dilated biliary tree depiction. Korean journal of radiology 20050101
Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodium-enhanced MR cholangiography versus conventional T2-weighted MR cholangiography. Radiology 20041201
Early biliary complications of laparoscopic cholecystectomy: evaluation on T2-weighted MR cholangiography in conjunction with mangafodipir trisodium-enhanced 3D T1-weighted MR cholangiography. AJR. American journal of roentgenology 20041201
[MRT of the liver. Clinical significance of nonspecific and liver-specific MRT contrast agents]. Der Radiologe 20041201
Relaxation enhancing properties of MnDPDP in human myocardium. Journal of magnetic resonance imaging : JMRI 20041201
Manganese toxicity upon overexposure. NMR in biomedicine 20041201
Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20041101
MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents. AJR. American journal of roentgenology 20041001
Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging. Journal of magnetic resonance imaging : JMRI 20041001
Magnetic resonance with manganese-DPDP (mangafodipir) of focal solid pancreatic lesions. La Radiologia medica 20040901
Contrast-enhanced magnetic resonance cholangiography using mangafodipir compared with standard T2W MRC sequences: a pictorial essay. Journal of magnetic resonance imaging : JMRI 20040801
MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine. Radiology 20040701
Diagnosing biliary complications of orthotopic liver transplantation with mangafodipir trisodium-enhanced MR cholangiography: comparison with conventional MR cholangiography. AJR. American journal of roentgenology 20040601
Mangafodipir-enhanced magnetic resonance cholangiography for the diagnosis of bile duct leaks. Gastrointestinal endoscopy 20040601
Identification and staging of pancreatic tumours using computed tomography, endoscopic ultrasound and mangafodipir trisodium-enhanced magnetic resonance imaging. Australasian radiology 20040601
Mangan-enhanced MR imaging for the detection and localisation of small pancreatic insulinoma. European radiology 20040501
Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging. Investigative radiology 20040501
Antioxidant activity of mangafodipir is not a new finding. Journal of hepatology 20040501
Small (<or= 2 cm) hepatic lesions in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI. AJR. American journal of roentgenology 20040501
Uptake of MnCl2 and mangafodipir trisodium in the myocardium: a magnetic resonance imaging study in pigs. Journal of magnetic resonance imaging : JMRI 20040501
Mn-DPDP-enhanced 24-h delayed-scan MRI of hepatocellular carcinoma is correlated with histology. European radiology 20040401
Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications. European radiology 20040401
Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience. Radiology 20040301
[Detection of liver metastases in colorectal cancer on chemotherapy. Comparative study between MRI with teslascan and computed tomography with intravenous contrast media]. Journal de radiologie 20040301
Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. European radiology 20040101
[Contribution of MR cholangiography after Teslascan infusion for the diagnosis of post-traumatic biliary injury]. Gastroenterologie clinique et biologique 20040101
Magnetic resonance cholangiography with mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after T-tube removal in liver transplantation. Journal of computer assisted tomography 20040101
Mangafodipir prevents liver injury induced by acetaminophen in the mouse. Journal of hepatology 20031101
Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast-enhanced magnetic resonance cholangiography. Journal of magnetic resonance imaging : JMRI 20031001
[Comparative study of four GRE sequences in MnDPDP-enhanced magnetic resonance imaging for primary hepatocellular carcinoma]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901
Intraoperative contrast-enhanced MR-imaging as predictor of tissue damage during cryoablation of porcine liver. Magnetic resonance imaging 20030901
Safety and efficacy of Mangafodipir trisodium in patients with liver lesions and cirrhosis. European radiology 20030701
Improved image contrast with mangafodipir trisodium (MnDPDP) during MR-guided percutaneous cryosurgery of the liver. Magnetic resonance imaging 20030701
Noninvasive preoperative evaluation of biliary anatomy in right-lobe living donors with mangafodipir trisodium-enhanced MR cholangiography. Transplantation proceedings 20030601
Acute cholecystitis at T2-weighted and manganese-enhanced T1-weighted MR cholangiography: preliminary study. Radiology 20030501
MnDPDP-enhanced magnetization transfer MR imaging: implications for effective liver imaging. Magnetic resonance imaging 20030101
Atypical focal nodular hyperplasia of the liver: imaging features of nonspecific and liver-specific MR contrast agents. AJR. American journal of roentgenology 20021201
Evaluation of focal pancreatic masses: comparison of mangafodipir-enhanced MR imaging and contrast-enhanced helical CT. European radiology 20021201
T1 efficacy of EVP-ABD: a potential manganese-based MR contrast agent for hepatic vascular and tissue phase imaging. Journal of magnetic resonance imaging : JMRI 20021201
Breast carcinoma metastases to the liver simulating cirrhosis. Radiology 20021201
MnDPDP enhanced magnetic resonance imaging of focal liver lesions. Clinical radiology 20021201
Intrahepatic biliary anatomy of living adult liver donors: correlation of mangafodipir trisodium-enhanced MR cholangiography and intraoperative cholangiography. AJR. American journal of roentgenology 20021101
[Focal secondary malignant liver lesions: MnDPDP-enhanced MRT at 0.2 tesla vs. helical CT-arterioportography]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20021101
[MnDPDP--contrast medium with protective effect in acute myocardial infarction]. Lakartidningen 20021003
Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. AJR. American journal of roentgenology 20020901
Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced versus mangafodipir trisodium-enhanced MR imaging. AJR. American journal of roentgenology 20020901
Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging. Chinese medical journal 20020901
Using contrast-enhanced MR cholangiography with IV mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after cholecystectomy: a prospective study of 11 patients. AJR. American journal of roentgenology 20020801
Liver lesion detection and characterization with sequential use of hepatobiliary contrast agent mangafodipir trisodium and gadolinium-DTPA in a single imaging protocol. Academic radiology 20020801
Exploring multifunctional features of necrosis avid contrast agents. Academic radiology 20020801
[MR imaging of pancreatic lesions with Mn-DPDP. A histopathologic correlation]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20020701
Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study. European radiology 20020601
Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT. Radiology 20020501
Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis. Radiology 20020501
Thallium-like test for myocardial viability with MnDPDP-enhanced MRI. Academic radiology 20020501
Multimodality diagnosis of liver tumors: feature analysis with CT, liver-specific and contrast-enhanced MR, and a computer model. Academic radiology 20020301
Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020301
Multifocal inflammatory pseudotumor of the liver: dynamic gadolinium-enhanced, ferumoxides-enhanced, and mangafodipir trisodium-enhanced MR imaging findings. European radiology 20020201
Functioning acinar cell pancreatic carcinoma: diagnosis on mangafodipir trisodium (Mn-DPDP)-enhanced MRI. Journal of computer assisted tomography 20020101
MRI characteristics in focal hepatic disease before and after administration of MnDPDP: discriminant analysis as a diagnostic tool. European radiology 20020101
Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results. Journal of computer assisted tomography 20020101
[Organ specific MRI contrast media in general practice]. Wiener medizinische Wochenschrift. Supplement 20020101
Contrast-enhanced magnetic resonance cholangiography versus heavily T2-weighted magnetic resonance cholangiography. Investigative radiology 20011101
New contrast agents for imaging the liver. Magnetic resonance imaging clinics of North America 20011101
Contrast-enhanced MR imaging in the diagnosis and preservation of cardiac viability. Acta radiologica (Stockholm, Sweden : 1987) 20011101
Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium. Acta radiologica (Stockholm, Sweden : 1987) 20011101
[Magnetic resonance imaging of the liver: what kind of contrast agents?]. La Radiologia medica 20010901
Clinical and cost effectiveness of a new hepatocellular MRI contrast agent, mangafodipir trisodium, in the preoperative assessment of liver resectability. Annals of surgical oncology 20010801
Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase. Journal of pharmaceutical and biomedical analysis 20010601
Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy. AJR. American journal of roentgenology 20010401
Determination of mangafodipir trisodium and related impurities in bulk substance and pharmaceutical formulation by ion-pair high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis 20010401
[Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20010301
Technical report: lymph node enhancement at MRI with MnDPDP in primary hepatic carcinoma. Clinical radiology 20010101
The value of MnDPDP enhancement during MR guided laser interstitial thermoablation of liver tumors. Journal of magnetic resonance imaging : JMRI 20010101
Detection of bile duct leaks using MR cholangiography with mangfodipir trisodium (Teslascan). Journal of computer assisted tomography 20010101
Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma. European radiology 20010101
Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). Journal of magnetic resonance imaging : JMRI 20000701
Mechanisms of action of liver contrast agents: impact for clinical use. Journal of computer assisted tomography 19991101
Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas. Acta radiologica. Supplementum 19980101
Dynamic evaluation of the hepatic uptake and clearance of manganese-based MRI contrast agents: a 31P NMR study on the isolated and perfused rat liver. Journal of magnetic resonance imaging : JMRI 19980101
Metabolism and pharmacokinetics of MnDPDP in man. Acta radiologica (Stockholm, Sweden : 1987) 19970701
Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration. Acta radiologica (Stockholm, Sweden : 1987) 19970701
Properties